Drug-Induced Nephrotoxicity and Drug Metabolism in Renal Failure.
PMID: 30009693 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 17, 2018 Category: Drugs & Pharmacology Authors: Huang J Tags: Curr Drug Metab Source Type: research

Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets.
Abstract Thiazides are the most commonly used medications for the treatment of mild and moderate hypertension. Despite their recognized effect, the mechanism by which thiazides reduce systemic blood pressure remains uncertain. The prevailing belief is that thiazides reduce blood pressure primarily via enhancement of salt excretion consequent to the inhibition of the Na-Cl cotransporter (NCC) in the distal convoluted tubules (DCT). However, recent reports point to a reduction in peripheral vascular resistance as a major mechanism of anti-hypertensive effect of thiazides. It is plausible that both mechanisms, renal ...
Source: Current Drug Metabolism - July 1, 2018 Category: Drugs & Pharmacology Authors: Pourafshar N, Alshahrani S, Karimi A, Soleimani M Tags: Curr Drug Metab Source Type: research

Optimization of Drugs Pharmacotherapy during Pregnancy Using Physiologically Based Pharmacokinetic Models - An Update.
CONCLUSION: More work is needed to fill the gaps in knowledge needed to more accurately and mechanistically simulate simultaneous exposure of the pregnant mother and her fetus/ embryo to drugs using pregnancy physiologically-based pharmacokinetic modeling approach. PMID: 29962340 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 1, 2018 Category: Drugs & Pharmacology Authors: Idkaidek N, Alsmadi MM Tags: Curr Drug Metab Source Type: research

Relevance of breast cancer resistance protein to brain distribution and central acting drugs: a pharmacokinetic perspective.
CONCLUSIONS: The clinical significance of BCRP in the disposition of drugs is currently undeniable. PMID: 29956624 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 29, 2018 Category: Drugs & Pharmacology Authors: Goncalves J, Bicker J, Alves G, Fortuna A, Falcao A Tags: Curr Drug Metab Source Type: research

Metabolism of Peptide Drugs and Strategies to Improve their Metabolic Stability.
Abstract Peptides are used increasingly as therapeutics and biomarkers because of the development of peptide synthesis technologies. Although peptides are associated with a variety of advantages that include high pharmaceutical activity and low toxicity, the therapeutic use of peptides is limited because of their poor metabolic stability in vivo. The main cause of this instability is that peptides are readily degraded by peptidases distributed widely in the body. This review summarizes peptidases present in the gastrointestinal tract, blood, liver, kidney, nasal cavity and placental barrier, and provides an overvi...
Source: Current Drug Metabolism - June 28, 2018 Category: Drugs & Pharmacology Authors: Yao JF, Yang H, Zhao YZ, Xue M Tags: Curr Drug Metab Source Type: research

Current Designs of Polymer Blends in Solid Dispersions for Improving Drug Bioavailability.
Abstract Ternary solid dispersions have been demonstrated to be an effective strategy in the improvement of drug absorption and bioavailability. The applications of the combination of hydrophilic polymers with the potential of hydrophobic polymer incorporation at moderate concentrations have been discussed in recent publications. In this paper, the general review of this specific type of solid dispersion will be provided with comprehensive understanding of polymer blends of either hydrophilic or hydrophobic polymers. A detailed description of miscible polymers has been developed in recent studies. In addition to d...
Source: Current Drug Metabolism - June 28, 2018 Category: Drugs & Pharmacology Authors: Tran PH, Duan W, Lee BJ, Tran TT Tags: Curr Drug Metab Source Type: research

Total sleep duration and risk of type 2 diabetes: Evidence based on clinical and epidemiological studies.
Abstract Increasing incidences of type 2 diabetes makes it necessary to have a better understanding of the risk factors for its prediction. Taking a note of resilience in risk factors, dynamics of the emerging factors other than traditional ones are showing a great interest in recent years which imprints a significant contribution in the occurrence of diabetes. Of different factors, sleep duration was acknowledged as a most common risk factor for dyslipidemia, obesity, hypertension, metabolic syndrome and diabetes. Adhering to the state of information available, the review highlights the underlying mechanisms towa...
Source: Current Drug Metabolism - June 28, 2018 Category: Drugs & Pharmacology Authors: Yadav D, Cho KH Tags: Curr Drug Metab Source Type: research

The Pharmacogenomics of Asthma beyond its Endotypes.
Abstract Asthma is a heterogeneous disease that consists of different phenotypes and endotypes, driven by different mechanistic pathways. An increasing number of genetic loci and single-nucleotide polymorphisms have been associated with therapeutic responses to asthma drugs. The purpose of this review is to focus on certain susceptibility genes, gene variants and typical therapeutic drugs of the glucocorticoid, leukotriene, histamine, and β2-adrenergic receptor pathways related to asthma. Pharmacogenomics can help us better understand the genetic basis of drug responses and better define new therapeutic targe...
Source: Current Drug Metabolism - June 28, 2018 Category: Drugs & Pharmacology Authors: Meng S, Chen S, Tao A Tags: Curr Drug Metab Source Type: research

Pharmacological and Therapeutic potential of Nitidine, a plant alkaloid.
Abstract Nitidine is a bioactive plant benzophenanthridine alkaloid isolated from the root of Zanthoxylum nitidum. Since its discovery in 1959, literature revealed marked anticancer, neuroprotective, antimalarial, anti-HIV, analgesic, anti-inflammatory, antifungal activities. MOE (molecular operating environment) ligand based pharmacophores features of nitidine showed that it has got multiple bioactive functional sites that implicating its sensitivity towards several receptors protein and therefore could be a useful lead compound. Despite having an outstanding therapeutic potential, it is not subjected to clinical...
Source: Current Drug Metabolism - June 28, 2018 Category: Drugs & Pharmacology Authors: Khan H, Hadda TB, Touzani R, Kamal MA Tags: Curr Drug Metab Source Type: research

Genetic Polymorphism on the Pharmacokinetics and Pharmacodynamics of Platelet-derived Growth Factor Receptor (PDGFR) Kinase Inhibitors.
This article also provides an overview of: (1) general information on PDGFR kinase inhibitors; (2) pharmacokinetic parameters of PDGFR kinase inhibitors; (3) metabolic enzymes and transporters of PDGFR kinase inhibitors; (4) main drug interactions of PDGFR kinase inhibitors; (5) adverse events of PDGFR kinase inhibitors; and (6) genetic polymorphism on pharmacokinetics and pharmacodynamics of PDGFR kinase inhibitors. PMID: 29956623 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 28, 2018 Category: Drugs & Pharmacology Authors: Qian Y, Yu L, Zhang XH, Yuan-Zi QY, Zhao P, Sun LN, Wang YQ Tags: Curr Drug Metab Source Type: research

The Role of E-cadherin in Helicobacter pylori-Related Gastric Diseases.
Abstract Helicobacter pylori (H. pylori)-related gastric diseases are a series of gastric mucosal disorders associated with H. pylori infection, including chronic gastritis, gastric ulcer and gastric cancer (GC) etc. The formation of GC is widely believed to be a multistep process, evolving from gastritis and gastric ulcer. Thus, to explore the mechanisms of gastric mucosa from benign to malignant pathological evolution process is the crux of prevention and treatment of GC. As an important adhesion molecule of epithelial cells, E-cadherin plays a key role in the development of gastric diseases. In this review, we ...
Source: Current Drug Metabolism - June 24, 2018 Category: Drugs & Pharmacology Authors: Zhang Y, Dai Y, Li R, Gao Y, Hu L Tags: Curr Drug Metab Source Type: research

Role of Osmolytes and their Transporter Systems in Pathogen Survival and Pathogenicity.
Abstract Pathogenic microbes routinely keep encountering different types of stress in their environment such as high osmolarity, high temperature, pH fluctuations in host gut etc. They tend to acquire certain small molecular weight molecules, termed osmolytes, so as to handle these challenges and survive despite them. These organic osmolytes even at higher concentrations are quite compatible with most of their ongoing intracellular processes. These osmolytes include some which are self-synthesized by the microorganisms, while majority of them are imbibed from the external environment via osmolyte transporters. In ...
Source: Current Drug Metabolism - June 24, 2018 Category: Drugs & Pharmacology Authors: Rahaman S, Archana A, Azam M, Minakshi R Tags: Curr Drug Metab Source Type: research

Recent advances in gold nanoformulations for cancer therapy.
Abstract Nanotechnology based diagnostic and therapeutic approaches have attracted great interest in oncology over the last few years. Especially gold (Au)-based nanoformulations have gained a lot of attention in cancer detection, therapy and monitoring of outcome. The current report provides a summary of methods how to prepare different types of synthetic gold nanoformulations and their potential applications in boosting photothermal and photodynamic tumor therapies and in radiosensitization. PMID: 29886825 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 10, 2018 Category: Drugs & Pharmacology Authors: Shevtsov M, Zhou Y, Khachatryan W, Multhoff G, Gao H Tags: Curr Drug Metab Source Type: research

The Therapeutic Role of Xenobiotic Nuclear Receptors against Metabolic Syndrome.
Abstract Xenobiotic nuclear receptors (XNRs) are nuclear receptors that characterized by coordinately regulating the expression of genes encoding drug-metabolizing enzymes and transporters to essentially eliminate and detoxify xenobiotics and endobiotics from the body, including the peroxisome proliferator-activated receptor (PPAR), the farnesoid X receptor (FXR), the liver X receptor (LXR), the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR). Heretofore, increasing evidences have suggested that these five XNRs are not only involved in the regulation of xeno-/endo-biotics detoxication but ...
Source: Current Drug Metabolism - June 10, 2018 Category: Drugs & Pharmacology Authors: Pu S, Wu X, Yang X, Zhang Y, Dai Y, Zhang Y, Wu X, Liu Y, Cui X, Jin H, Cao J, Li R, Cai J, Cao Q, Hu L, Gao Y Tags: Curr Drug Metab Source Type: research

Amino acid metabolism in dairy cows and their regulation in milk synthesis.
Abstract Reducing dietary crude protein (CP) and supplementing with certain amino acids (AAs) has been known as a potential solution to improve nitrogen (N) efficiency in dairy production. Thus understanding how AAs are utilized in various sites along the gut is critical. AA flow from the intestine to portal-drained viscera (PDV) and liver then to the mammary gland was elaborated in this article. Recoveries in individual AA in PDV and liver seem to share similar AA pattern with input: output ratio in mammary gland, which subdivides essential AA (EAA) into two groups, lysine (Lys) and branched-chain AA (BCAA) in gr...
Source: Current Drug Metabolism - June 10, 2018 Category: Drugs & Pharmacology Authors: Wang F, Shi H, Wang S, Wang Y, Cao Z, Li S Tags: Curr Drug Metab Source Type: research

Hypoxia plays a key role in the pharmacokinetic changes of drugs at high altitude.
Abstract Hypoxia can alter the pharmacokinetic (PK) characteristics of drugs, thereby affecting drug absorption, distribution, metabolism, and excretion. Environmental characteristics at high altitude include but are not limited to hypobaric hypoxia, low temperature, high solar radiation, and arid climate, all of which can adversely affect normal bodily functions. Recent studies have indicated that hypoxia may play a key role in the PK changes of drugs at high altitude. Here we reported the effects of hypoxia on drug metabolism at high altitude, elaborated on the metabolic characteristics of some drugs and the act...
Source: Current Drug Metabolism - May 28, 2018 Category: Drugs & Pharmacology Authors: Zhou X, Nian Y, Qiao Y, Yang M, Xin Y, Li X Tags: Curr Drug Metab Source Type: research

Failure of Chemotherapy in Hepatocellular Carcinoma Due to Impaired and Dysregulated Primary Liver Drug Metabolizing Enzymes and Drug Transport Proteins: What to Do?
CONCLUSION: The future of HCC treatment should emphasize the understanding of resistance mechanisms and the finding of novel, safe, and efficacious therapeutic strategies, which will surely benefit patients affected by advanced HCC. PMID: 29807513 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 28, 2018 Category: Drugs & Pharmacology Authors: Ul Islam S, Ahmed MB, Shehzad A, Ul-Islam M, Lee YS Tags: Curr Drug Metab Source Type: research

A Review on the Expression and Metabolic Features of Orphan Human Cytochrome P450 2S1 (CYP2S1).
CONCLUSION: Molecular-based investigations should be performed to better understand the regulation mechanism of CYP2S1 in various cells and tissues. It is pivotal to establish optimum expression and incubation systems in vitro to elucidate the substrate specificity of CYP2S1 and characterise the genetic consequences of variant CYP2S1 in vitro. PMID: 29804525 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 27, 2018 Category: Drugs & Pharmacology Authors: Yan P, Eng OC, Yu CJ Tags: Curr Drug Metab Source Type: research

Editorial: Integrative Approach to Manage Neurological Disorders.
PMID: 29788866 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 25, 2018 Category: Drugs & Pharmacology Authors: Zargaran A Tags: Curr Drug Metab Source Type: research

Impact of Drug Metabolism/Pharmacokinetics and Their Relevance upon Taxus-based Drug Development.
Abstract Drug metabolism and pharmacokinetic (DMPK) studies of Taxus natural products, their semi-synthetic derivatives and analogs are indispensable in the optimization of lead compounds and clinical therapy. These studies can lead to development of new drug entities with improved absorption, distribution, metabolism, excretion and toxicity (ADME/T) profiles. To date, there have been no comprehensive reviews of the DMPK features of Taxus derived medicinal compounds.Natural and semi-synthetic taxanes may cause and could be affected by drug-drug interaction (DDI). Hence ADME/T studies of various taxane-containing f...
Source: Current Drug Metabolism - May 22, 2018 Category: Drugs & Pharmacology Authors: Hao DC, Ge GB, Wang P, Yang L Tags: Curr Drug Metab Source Type: research

Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives.
Abstract Drug-induced liver injury (DILI) is an important cause of acute liver failure cases in the United States, and remains a common cause of withdrawal of drugs in both preclinical and clinical phases. In this article, we review the existing knowledge of appropriate models to study DILI in vitro and in vivo with special focus on hepatic cell models, variations of 3D co-cultures, animal models, databases and predictive modeling and translational biomarkers developed to understand the mechanisms and pathophysiology of DILI. Besides descriptions of current applications of existing modeling systems, associated adv...
Source: Current Drug Metabolism - May 22, 2018 Category: Drugs & Pharmacology Authors: Kuna L, Bozic I, Kizivat T, Bojanic K, Mrso M, Kralj E, Smolic R, Wu GY, Smolic M Tags: Curr Drug Metab Source Type: research

Progress of Oral Insulin and Related Drug Delivery Systems and their Pharmacokinetics.
CONCLUSION: This review summarized recent advances in oral insulin and the pharmacokinetic profile of the suitable delivery system, providing valuable reference material for future research. PMID: 29788884 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 22, 2018 Category: Drugs & Pharmacology Authors: Chen J, Liu R, Liu C, Jin X, Zhang Q, Wang J, Zhao F, Wang Z, Qiu H, Li Y, Yi X Tags: Curr Drug Metab Source Type: research

Application of Traditional Chinese Herbal Medicine By-products as Dietary Feed Supplements and Antibiotic Replacements in Animal Production.
Abstract Misuse of synthetic antibiotics in livestock leads to the transfer of antibiotic resistant pathogens into humans and deposits toxic residues in meat and milk. There is therefore an urgent need for safe and viable alternative approaches to improve the nutrition and wellbeing of farm animals. An alternative source that has been widely exploited is traditional Chinese herbal medicine (TCHM). These herbal medicines are an important part of the healthcare system in many Asian countries. Such herbs contain several but less toxic bioactive compounds which are generally regarded biodegradable. Recently, advances ...
Source: Current Drug Metabolism - May 22, 2018 Category: Drugs & Pharmacology Authors: Abdallah A, Zhang P, Zhong Q, Sun Z Tags: Curr Drug Metab Source Type: research

Editorial: Therapeutic Advances and their Biomedical Perspectives - Part 2.
PMID: 29756569 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 15, 2018 Category: Drugs & Pharmacology Authors: Dhama K, Malik YS Tags: Curr Drug Metab Source Type: research

An Introduction of the Guest Editors.
PMID: 29756570 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 15, 2018 Category: Drugs & Pharmacology Authors: Dhama K, Malik YS Tags: Curr Drug Metab Source Type: research

Advances in Long-Circulating Drug Delivery Strategy.
Abstract For safe and effective therapy, drugs are supposed to be actively targeted at the desired disease locations. As a promising candidate for drug delivery, long circulating system with various strategies has been widely used. Recently, biomimetic strategies mediated long circulation of drug delivery system have been increasingly developed for forming various nanoparticles and shown the anticipated potential. In this review, a variety of approaches for long circulation strategy have been surveyed, together with different modifications. The future perspectives as well as challenges in this field are also discu...
Source: Current Drug Metabolism - May 11, 2018 Category: Drugs & Pharmacology Authors: Zhang X, Zhang S, Kang Y, Huang K, Gu Z, Wu J Tags: Curr Drug Metab Source Type: research

Polysaccharide Nanoparticles for Targeted Cancer Therapies.
Abstract Nanomedicines are novel drug delivery systems which can be devised to optimize the biodistribution, pharmacokinetics and pharmacodynamics of single or multiple drugs to improve the therapeutic index, reduce the systemic toxicity and increase the antitumor efficacy. Numerous classes of materials have been applied to construct nanomedicines, while the potential safety concern raised from the synthetic components during construction significantly impedes the clinical translation of nanomedicines. In virtue of their unique hydrophilicity, biocompatibility, biodegradability and modifiability, natural biopolyme...
Source: Current Drug Metabolism - May 11, 2018 Category: Drugs & Pharmacology Authors: Peng P, Yang K, Tong G, Ma L Tags: Curr Drug Metab Source Type: research

The application of natural products in cancer therapy by targeting apoptosis pathways.
Abstract Apoptosis is one of the pathways of programmed cell death (PCD), which leads to pathognomic cellular changes different from cellular necrosis. It includes the death receptor pathway and the mitochondrial pathway, both of which involve many key proteins, including cytochrome c, Fas, the Bcl-2 family, caspases, survivin and p53. In apoptosis-related diseases, such as cancer, many proteins associated with apoptosis are abnormally expressed. The majority of anti-cancer agents promote apoptosis to induce cancer cell death. Furthermore, numerous natural products have been reported to induce the cell apoptosis b...
Source: Current Drug Metabolism - May 11, 2018 Category: Drugs & Pharmacology Authors: Wang Y, Zhong J, Bai J, Tonga R, An F, Jiao P, He L, Zeng D, Long E, Yan J, Yu J, Cai L Tags: Curr Drug Metab Source Type: research

The relationship between Lithium and cancer proliferation: A case-based review of the literature.
CONCLUSION: Despite the presence of contradictory data, a substantial body of evidence mainly from molecular studies point to Li's anti-carcinogenic effects. However, the underlying mechanistic pathways remain unclear. Mitochondrial dysfunction and redox modulations are potential areas for research on the relationship between Li and cancer proliferation. PMID: 29708074 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 29, 2018 Category: Drugs & Pharmacology Authors: Ozerdem A, Ceylan D, Targıtay B Tags: Curr Drug Metab Source Type: research

Indoles - gut bacteria metabolites of tryptophan with pharmacotherapeutic potential.
Abstract Increasing evidence proves the pivotal role of gut microbiota in mammals' homeostasis. Gut bacterial metabolites may exert local effects on the intestines, and may enter the circulation, affecting the functions of virtually all organs. Indoles represent a wide group of gut bacteria-derived compounds produced from tryptophan, an essential amino acid and the precursor of endogenous synthesis of tryptamine, serotonin and melatonin. Recently, it has been suggested that gut microbiota and their metabolites, including indoles, may be involved in the etiology of cardiovascular, metabolic, and psychiatric disease...
Source: Current Drug Metabolism - April 27, 2018 Category: Drugs & Pharmacology Authors: Konopelski P, Ufnal M Tags: Curr Drug Metab Source Type: research

Drug-induced cholestasis: mechanisms, models, and markers.
Abstract Drug-induced cholestasis is a risk factor in progression of drug candidates, and poses serious health hazard if not detected before going into human. Intrahepatic accumulation of bile acids (BAs) represents a characteristic phenomenon associated with drug-induced cholestasis. The major challenges in obtaining a complete understanding of drug-induced cholestasis lies in the complexity of BA-mediated toxicity mechanisms and the impact of bile acids at different 'targets' such as transporters, enzymes and nuclear receptors. At the same time, it is not trivial to have a relevant in vitro system that recapitul...
Source: Current Drug Metabolism - April 27, 2018 Category: Drugs & Pharmacology Authors: Chatterjee S, Annaert P Tags: Curr Drug Metab Source Type: research

Research Progress of Progesterone Preparations: a mini Review.
CONCLUSION: Although progesterone has first-pass effects, with these methods, the bioavailability and compliance can greatly increase. PMID: 29708071 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 27, 2018 Category: Drugs & Pharmacology Authors: Ye M, Pan W, Yang X, Zhang X Tags: Curr Drug Metab Source Type: research

A Review on Clinical Pharmacokinetics, Pharmacodynamics, and pharmacogenomics of natalizumab: A Humanized Anti- α4 Integrin Monoclonal Antibody.
A Review on Clinical Pharmacokinetics, Pharmacodynamics, and pharmacogenomics of natalizumab: A Humanized Anti-α4 Integrin Monoclonal Antibody. Curr Drug Metab. 2018 Apr 27;: Authors: Hao L, Fang-Hong S, Shi-Ying H, Shun-Guo Z, Min-Ling C Abstract Natalizumab (Tysabri®, Biogen-Idec Inc., NAT), a humanized anti-α4 integrin monoclonal antibody, binds in both α4β1 (Very Late Antigen 4, VLA-4) and α4β7 (lymphocytes Peyer's patch adhesion molecule 1, LPAM-1) integrins, is approved for the treatment of Multiple sclerosis (MS) and Crohn's disease (CD). NAT has been well ...
Source: Current Drug Metabolism - April 27, 2018 Category: Drugs & Pharmacology Authors: Hao L, Fang-Hong S, Shi-Ying H, Shun-Guo Z, Min-Ling C Tags: Curr Drug Metab Source Type: research

Soy isoflavones and their effects on xenobiotic metabolism.
CONCLUSION: This review summarized different aspects of soy isoflavones and their molecular mechanisms of pharmacological action on xenobiotic, which demonstrated that soy isoflavones can decrease the incidence of many diseases and benefit for human health. However, since the lack of clinical research for evaluation of the proper dosage of intake of soy isoflavones in diet or adjunctive therapy, there is a need for further studies on the selection of doses, biomedical applications and adverse effects of isoflavones for human health. PMID: 29708073 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 27, 2018 Category: Drugs & Pharmacology Authors: Zhou T, Meng C, He P Tags: Curr Drug Metab Source Type: research

Editorial: Efficacy, Toxicology, and PK/PD of Nanomedicine Administrated by Different Strategies.
PMID: 29687764 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 25, 2018 Category: Drugs & Pharmacology Authors: Meng X Tags: Curr Drug Metab Source Type: research

Role of Angiogenenic Growth Factors In Psoriasis: A Review.
CONCLUSION: Anti-angiogenesis therapies targeting vaso-proliferation may represent a valid approach for the development of anti-psoriatic drugs and further development in this field can pave a way to new fields of treatment which could be complementary to those directly targeting inflammation. PMID: 29663878 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 16, 2018 Category: Drugs & Pharmacology Authors: Akhtar T, Wani WY, Kamal MA, Kaur R Tags: Curr Drug Metab Source Type: research

Anti-cancer Effects of Metformin: Recent Evidences for its Role in Prevention and Treatment of Cancer.
Abstract Metformin is widely used for the management of type 2 diabetes mellitus (T2DM). Recently growing evidence has shown its anti-cancer effects. The results are mainly obtained from observational studies and thus, little information is available concerning the mechanisms of action. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays an important role in the mechanism of action of metformin. The anti-cancer mechanisms of metformin include direct and indirect effects. The direct effects of metformin include AMPK-independent and AMPK-dependent effects, whereas the decrease in glucose level, hyper...
Source: Current Drug Metabolism - April 16, 2018 Category: Drugs & Pharmacology Authors: Kheirandish M, Mahboobi H, Yazdanparast M, Kamal W, Kamal MA Tags: Curr Drug Metab Source Type: research

Preface.
PMID: 29618306 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 7, 2018 Category: Drugs & Pharmacology Authors: Sinz M Tags: Curr Drug Metab Source Type: research

Potential pharmacokinetic herb-drug interactions: have we overlooked the importance of human carboxylesterases 1 and 2?
Abstract Herbal products have grown steadily across the globe over the past 10 years and have increasingly been incorporated into western medicine for healthcare aims, thereby causing potential pharmacokinetic herb-drug interactions (HDI) through the inhibition or induction of drug-metabolizing enzymes and transporters. Human carboxylesterases 1 (CES1) and 2 (CES2) are versatile enzymes involvement in the metabolism of endogenous and exogenous compounds including many important therapeutic medications. Moreover, the growing number of CES substrate drugs also underscores the importance of CES1 and CES2. Here, we su...
Source: Current Drug Metabolism - March 30, 2018 Category: Drugs & Pharmacology Authors: Xu J, Qiu JC, Ji X, Guo HL, Wang X, Zhang B, Wang T, Chen F Tags: Curr Drug Metab Source Type: research

Preclinical Hepatoprotective Effect of Herbalism against Ethanol Induced Hepatotoxicity: A Review.
Abstract Liver ailments including alcoholic liver disease (ALD), still remain the main reason for morbidity & mortality worldwide. In fact, ALD is a multifactorial disease with complex pathophysiology which is linked to several types of liver damages including steatohepatitis, fibrosis and cirrhosis. This review emphasizes on 30 herbal medicinal plants with their extracts studied for protective effect against ALD and current scientific evidence of ALD cure by thirty Indian Materia Medica including Tilia Platyphyllos, Amomum subulatum, Carica papaya, Pogostemon patchouli, Commelina benghalensis, Bacopamonnieri,...
Source: Current Drug Metabolism - March 30, 2018 Category: Drugs & Pharmacology Authors: Firdous H, Hussain T, Singh M, Rizvi SMD, Moin A, Kamal MA Tags: Curr Drug Metab Source Type: research

Application of medicinal plants as a source for therapeutic agents against Streptococcus pyogenes infections.
Abstract Streptococcus pyogenes, a major human pathogen, causes a wide variety of invasive systemic infections such as acute pharyngitis, skin and soft-tissue infections, especially necrotizing fasciitis. This Gram-positive bacterium has an ability to form mature biofilm and this sessile lifestyle plays an important role in S. pyogenes pathogenicity. The virulence of these bacteria is further strengthened by its ability to communicate within the micro-colonies through quorum sensing. Most treatments are now aimed at either elimination of this bacterium or suppression of its virulence. The emergence of antibiotic r...
Source: Current Drug Metabolism - March 29, 2018 Category: Drugs & Pharmacology Authors: Mohd A, Rupasinghe HPV Tags: Curr Drug Metab Source Type: research

Association of Metronidazole with Cancer: A Potential Risk Factor or Inconsistent Deductions?
Abstract Metronidazole is a synthetic derivative of nitroimidazole that has been widely used for the treatment of several bacterial and protozoal parasitic infections including trichomoniasis, amoebiasis, giardiasis, liver abscess, acute ulcerative gingivitis, syphilis and tropical phagedena. In addition to its toxicity in the gastrointestinal tract and central/peripheral nervous system, metronidazole has been reported to cause mucosal imbalance by affecting the expression of mucin (Muc2 gene), which is responsible to form an insoluble mucous barrier that protects the gut lumen from microbial colonization. Since m...
Source: Current Drug Metabolism - March 29, 2018 Category: Drugs & Pharmacology Authors: Adil M, Iqbal W, Adnan F, Wazir S, Khan I, Khayam MU, Kamal MA, Ahmad S, Ahmad J, Khan IN Tags: Curr Drug Metab Source Type: research

Pasireotide - mechanism of action and clinical applications.
Abstract Pasireotide (SOM230) is a multi-receptor ligand somatostatin analogue (SSA) developed as the successor of the first-generation SSAs. Currently, pasireotide is recommended for the treatment of patients with Cushing's disease in whom surgery was unsuccessful, and patients with acromegaly who either remain uncontrolled after surgical therapy or in whom tumor resection is not possible. Phase II and III clinical trials have shown pasireotide efficacy in these diseases, with a similar rate of adverse events when compared with first-line SSA, although higher incidence of hyperglycemia has been observed. Pasireot...
Source: Current Drug Metabolism - March 27, 2018 Category: Drugs & Pharmacology Authors: Sawicka-Gutaj N, Owecki M, Ruchala M Tags: Curr Drug Metab Source Type: research

Kidney-on-a-Chip: a New Technology for Predicting Drug Efficacy, Interactions, and Drug-induced Nephrotoxicity.
Abstract The kidneys play a pivotal role in most drug-removal processes and are important when evaluating drug safety. Kidney dysfunction resulting from various drugs is an important issue in clinical practice and during the drug development process. Traditional in vivo animal experiments are limited with respect to evaluating drug efficacy and nephrotoxicity due to discrepancies in drug pharmacokinetics and pharmacodynamics between humans and animals, and static cell culture experiments cannot fully reflect the actual microphysiological environment in humans. A kidney-on-a-chip is a microfluidic device that allo...
Source: Current Drug Metabolism - March 8, 2018 Category: Drugs & Pharmacology Authors: Lee J, Kim S Tags: Curr Drug Metab Source Type: research

Regulation of Mammalian UDP-glucuronosyltransferases.
Abstract UDP-glucuronosyltransferases (UGTs) are a class of important phase II drug metabolizing enzymes (DMEs), playing essential roles in the homeostasis of endobiotics as well as the dispositional behavior of exogenous compounds. The expression and enzyme activity of UGTs are regulated by multiple dimensions of mechanisms and can be influenced by diverse factors. Thus, the intensive research of its regulatory network is pivotal for better understanding about the physiological, pathological, and therapeutic significance of UGTs. Despite the lag to the research in cytochrome P450s, extensive efforts have been mad...
Source: Current Drug Metabolism - March 7, 2018 Category: Drugs & Pharmacology Authors: Wang H, Cao G, Wang G, Hao H Tags: Curr Drug Metab Source Type: research

Therapeutic uses of HSP90 inhibitors in Non-Small Cell Lung Carcinoma (NSCLC).
CONCLUSION: The goal of this review is to present the data in support to the use of HSP90 inhibitors in NSCLC and to provide an overview of the on-going clinical trials involving new-generation HSP90 inhibitors. PMID: 29521219 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 7, 2018 Category: Drugs & Pharmacology Authors: Akram A, Khalil S, Halim SA Tags: Curr Drug Metab Source Type: research

Current therapeutic approaches for targeting inflammation in depression and cardiovascular disease.
CONCLUSION: Strategies that can mitigate this risk profile are highly needed in the clinical setting, and these particular group of drugs has the possibility of becoming increasingly important in treatment strategies aiming to improve both conditions. PMID: 29512447 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 5, 2018 Category: Drugs & Pharmacology Authors: Zuzarte P, Duong A, Figueira ML, Vitali AC, Scola G Tags: Curr Drug Metab Source Type: research

Frontier view on nanotechnological strategies for neuro-therapy.
Abstract Nanotechnology exploits materials and devices with a functional organization that has been engineered at the nanometre scale. The application of nanotechnology in neuroscience involves specific interactions with neurons and glial cells. This property is used for delivering drugs and other small molecules (such as genes, oligonucleotides and contrasting agents) across the blood brain barrier (BBB), an important requirement for delivering the drug successfully to the brain. Nanotechnology based approaches (NBA) favoured transcytosis-mediated delivery of nanoparticles to the brain by crossing the BBB. The la...
Source: Current Drug Metabolism - March 5, 2018 Category: Drugs & Pharmacology Authors: Azhar A, Zia Q, Ansari SA, Kamal MA, Alexiou A, Yarla NS, Ashraf GM Tags: Curr Drug Metab Source Type: research

Sodium Oxybate treatment in pediatric type 1 narcolepsy.
Abstract Narcolepsy type 1 (NT1) is a rare chronic neurologic disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hallucinations and disrupted nocturnal sleep, usually with onset during childhood/adolescence. Pediatric NT1 is associated with limitations on children's activities and achievements, especially poor performance at school, difficulty with peers due to disease symptoms and comorbidities including depression, obesity, and precocious puberty. NT1 disease is caused by the selective loss of hypocretin-producing neurons in the lateral hypothalamus, most probably related to an a...
Source: Current Drug Metabolism - March 5, 2018 Category: Drugs & Pharmacology Authors: Moresco M, Pizza F, Antelmi E, Plazzi G Tags: Curr Drug Metab Source Type: research

Pharmacokinetics, Metabolism, Distribution and Permeability of Nanomedicine.
Conclusion Nanomedicine is increasingly becoming important in the treatment of diseases and diagnosis. Size of the particle plays an important role. As the particle size decreases its effect to cure the disease increases. Pharmacokinetics, bioavailability, half-life, metabolism, biodistribution and permeability of nanomedicine were found to be better than that of microsized drugs. In Vitro and In Vivo ADME (Absorption, Distribution, Metabolism and Excretion) studies are mandatory for pharmaceutical organic drugs. Similarly, nanomaterials should be subjected through both in vitro and in vivo ADME studies. Thus, nanomedicine...
Source: Current Drug Metabolism - March 5, 2018 Category: Drugs & Pharmacology Authors: Ravindran S, Suthar JK, Rokade R, Deshpande P, Singh P, Pratinidhi A, Khambadkhar R, Utekar S Tags: Curr Drug Metab Source Type: research