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Editorial: Therapeutic Advances and their Biomedical Perspectives - Part 2.
PMID: 29756569 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 15, 2018 Category: Drugs & Pharmacology Authors: Dhama K, Malik YS Tags: Curr Drug Metab Source Type: research

An Introduction of the Guest Editors.
PMID: 29756570 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 15, 2018 Category: Drugs & Pharmacology Authors: Dhama K, Malik YS Tags: Curr Drug Metab Source Type: research

Advances in Long-Circulating Drug Delivery Strategy.
Abstract For safe and effective therapy, drugs are supposed to be actively targeted at the desired disease locations. As a promising candidate for drug delivery, long circulating system with various strategies has been widely used. Recently, biomimetic strategies mediated long circulation of drug delivery system have been increasingly developed for forming various nanoparticles and shown the anticipated potential. In this review, a variety of approaches for long circulation strategy have been surveyed, together with different modifications. The future perspectives as well as challenges in this field are also discu...
Source: Current Drug Metabolism - May 11, 2018 Category: Drugs & Pharmacology Authors: Zhang X, Zhang S, Kang Y, Huang K, Gu Z, Wu J Tags: Curr Drug Metab Source Type: research

Polysaccharide Nanoparticles for Targeted Cancer Therapies.
Abstract Nanomedicines are novel drug delivery systems which can be devised to optimize the biodistribution, pharmacokinetics and pharmacodynamics of single or multiple drugs to improve the therapeutic index, reduce the systemic toxicity and increase the antitumor efficacy. Numerous classes of materials have been applied to construct nanomedicines, while the potential safety concern raised from the synthetic components during construction significantly impedes the clinical translation of nanomedicines. In virtue of their unique hydrophilicity, biocompatibility, biodegradability and modifiability, natural biopolyme...
Source: Current Drug Metabolism - May 11, 2018 Category: Drugs & Pharmacology Authors: Peng P, Yang K, Tong G, Ma L Tags: Curr Drug Metab Source Type: research

The application of natural products in cancer therapy by targeting apoptosis pathways.
Abstract Apoptosis is one of the pathways of programmed cell death (PCD), which leads to pathognomic cellular changes different from cellular necrosis. It includes the death receptor pathway and the mitochondrial pathway, both of which involve many key proteins, including cytochrome c, Fas, the Bcl-2 family, caspases, survivin and p53. In apoptosis-related diseases, such as cancer, many proteins associated with apoptosis are abnormally expressed. The majority of anti-cancer agents promote apoptosis to induce cancer cell death. Furthermore, numerous natural products have been reported to induce the cell apoptosis b...
Source: Current Drug Metabolism - May 11, 2018 Category: Drugs & Pharmacology Authors: Wang Y, Zhong J, Bai J, Tonga R, An F, Jiao P, He L, Zeng D, Long E, Yan J, Yu J, Cai L Tags: Curr Drug Metab Source Type: research

The relationship between Lithium and cancer proliferation: A case-based review of the literature.
CONCLUSION: Despite the presence of contradictory data, a substantial body of evidence mainly from molecular studies point to Li's anti-carcinogenic effects. However, the underlying mechanistic pathways remain unclear. Mitochondrial dysfunction and redox modulations are potential areas for research on the relationship between Li and cancer proliferation. PMID: 29708074 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 29, 2018 Category: Drugs & Pharmacology Authors: Ozerdem A, Ceylan D, Targıtay B Tags: Curr Drug Metab Source Type: research

Indoles - gut bacteria metabolites of tryptophan with pharmacotherapeutic potential.
Abstract Increasing evidence proves the pivotal role of gut microbiota in mammals' homeostasis. Gut bacterial metabolites may exert local effects on the intestines, and may enter the circulation, affecting the functions of virtually all organs. Indoles represent a wide group of gut bacteria-derived compounds produced from tryptophan, an essential amino acid and the precursor of endogenous synthesis of tryptamine, serotonin and melatonin. Recently, it has been suggested that gut microbiota and their metabolites, including indoles, may be involved in the etiology of cardiovascular, metabolic, and psychiatric disease...
Source: Current Drug Metabolism - April 27, 2018 Category: Drugs & Pharmacology Authors: Konopelski P, Ufnal M Tags: Curr Drug Metab Source Type: research

Drug-induced cholestasis: mechanisms, models, and markers.
Abstract Drug-induced cholestasis is a risk factor in progression of drug candidates, and poses serious health hazard if not detected before going into human. Intrahepatic accumulation of bile acids (BAs) represents a characteristic phenomenon associated with drug-induced cholestasis. The major challenges in obtaining a complete understanding of drug-induced cholestasis lies in the complexity of BA-mediated toxicity mechanisms and the impact of bile acids at different 'targets' such as transporters, enzymes and nuclear receptors. At the same time, it is not trivial to have a relevant in vitro system that recapitul...
Source: Current Drug Metabolism - April 27, 2018 Category: Drugs & Pharmacology Authors: Chatterjee S, Annaert P Tags: Curr Drug Metab Source Type: research

Research Progress of Progesterone Preparations: a mini Review.
CONCLUSION: Although progesterone has first-pass effects, with these methods, the bioavailability and compliance can greatly increase. PMID: 29708071 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 27, 2018 Category: Drugs & Pharmacology Authors: Ye M, Pan W, Yang X, Zhang X Tags: Curr Drug Metab Source Type: research

A Review on Clinical Pharmacokinetics, Pharmacodynamics, and pharmacogenomics of natalizumab: A Humanized Anti- α4 Integrin Monoclonal Antibody.
A Review on Clinical Pharmacokinetics, Pharmacodynamics, and pharmacogenomics of natalizumab: A Humanized Anti-α4 Integrin Monoclonal Antibody. Curr Drug Metab. 2018 Apr 27;: Authors: Hao L, Fang-Hong S, Shi-Ying H, Shun-Guo Z, Min-Ling C Abstract Natalizumab (Tysabri®, Biogen-Idec Inc., NAT), a humanized anti-α4 integrin monoclonal antibody, binds in both α4β1 (Very Late Antigen 4, VLA-4) and α4β7 (lymphocytes Peyer's patch adhesion molecule 1, LPAM-1) integrins, is approved for the treatment of Multiple sclerosis (MS) and Crohn's disease (CD). NAT has been well ...
Source: Current Drug Metabolism - April 27, 2018 Category: Drugs & Pharmacology Authors: Hao L, Fang-Hong S, Shi-Ying H, Shun-Guo Z, Min-Ling C Tags: Curr Drug Metab Source Type: research

Soy isoflavones and their effects on xenobiotic metabolism.
CONCLUSION: This review summarized different aspects of soy isoflavones and their molecular mechanisms of pharmacological action on xenobiotic, which demonstrated that soy isoflavones can decrease the incidence of many diseases and benefit for human health. However, since the lack of clinical research for evaluation of the proper dosage of intake of soy isoflavones in diet or adjunctive therapy, there is a need for further studies on the selection of doses, biomedical applications and adverse effects of isoflavones for human health. PMID: 29708073 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 27, 2018 Category: Drugs & Pharmacology Authors: Zhou T, Meng C, He P Tags: Curr Drug Metab Source Type: research

Editorial: Efficacy, Toxicology, and PK/PD of Nanomedicine Administrated by Different Strategies.
PMID: 29687764 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 25, 2018 Category: Drugs & Pharmacology Authors: Meng X Tags: Curr Drug Metab Source Type: research

Role of Angiogenenic Growth Factors In Psoriasis: A Review.
CONCLUSION: Anti-angiogenesis therapies targeting vaso-proliferation may represent a valid approach for the development of anti-psoriatic drugs and further development in this field can pave a way to new fields of treatment which could be complementary to those directly targeting inflammation. PMID: 29663878 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 16, 2018 Category: Drugs & Pharmacology Authors: Akhtar T, Wani WY, Kamal MA, Kaur R Tags: Curr Drug Metab Source Type: research

Anti-cancer Effects of Metformin: Recent Evidences for its Role in Prevention and Treatment of Cancer.
Abstract Metformin is widely used for the management of type 2 diabetes mellitus (T2DM). Recently growing evidence has shown its anti-cancer effects. The results are mainly obtained from observational studies and thus, little information is available concerning the mechanisms of action. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays an important role in the mechanism of action of metformin. The anti-cancer mechanisms of metformin include direct and indirect effects. The direct effects of metformin include AMPK-independent and AMPK-dependent effects, whereas the decrease in glucose level, hyper...
Source: Current Drug Metabolism - April 16, 2018 Category: Drugs & Pharmacology Authors: Kheirandish M, Mahboobi H, Yazdanparast M, Kamal W, Kamal MA Tags: Curr Drug Metab Source Type: research

Preface.
PMID: 29618306 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 7, 2018 Category: Drugs & Pharmacology Authors: Sinz M Tags: Curr Drug Metab Source Type: research

Potential pharmacokinetic herb-drug interactions: have we overlooked the importance of human carboxylesterases 1 and 2?
Abstract Herbal products have grown steadily across the globe over the past 10 years and have increasingly been incorporated into western medicine for healthcare aims, thereby causing potential pharmacokinetic herb-drug interactions (HDI) through the inhibition or induction of drug-metabolizing enzymes and transporters. Human carboxylesterases 1 (CES1) and 2 (CES2) are versatile enzymes involvement in the metabolism of endogenous and exogenous compounds including many important therapeutic medications. Moreover, the growing number of CES substrate drugs also underscores the importance of CES1 and CES2. Here, we su...
Source: Current Drug Metabolism - March 30, 2018 Category: Drugs & Pharmacology Authors: Xu J, Qiu JC, Ji X, Guo HL, Wang X, Zhang B, Wang T, Chen F Tags: Curr Drug Metab Source Type: research

Preclinical Hepatoprotective Effect of Herbalism against Ethanol Induced Hepatotoxicity: A Review.
Abstract Liver ailments including alcoholic liver disease (ALD), still remain the main reason for morbidity & mortality worldwide. In fact, ALD is a multifactorial disease with complex pathophysiology which is linked to several types of liver damages including steatohepatitis, fibrosis and cirrhosis. This review emphasizes on 30 herbal medicinal plants with their extracts studied for protective effect against ALD and current scientific evidence of ALD cure by thirty Indian Materia Medica including Tilia Platyphyllos, Amomum subulatum, Carica papaya, Pogostemon patchouli, Commelina benghalensis, Bacopamonnieri,...
Source: Current Drug Metabolism - March 30, 2018 Category: Drugs & Pharmacology Authors: Firdous H, Hussain T, Singh M, Rizvi SMD, Moin A, Kamal MA Tags: Curr Drug Metab Source Type: research

Application of medicinal plants as a source for therapeutic agents against Streptococcus pyogenes infections.
Abstract Streptococcus pyogenes, a major human pathogen, causes a wide variety of invasive systemic infections such as acute pharyngitis, skin and soft-tissue infections, especially necrotizing fasciitis. This Gram-positive bacterium has an ability to form mature biofilm and this sessile lifestyle plays an important role in S. pyogenes pathogenicity. The virulence of these bacteria is further strengthened by its ability to communicate within the micro-colonies through quorum sensing. Most treatments are now aimed at either elimination of this bacterium or suppression of its virulence. The emergence of antibiotic r...
Source: Current Drug Metabolism - March 29, 2018 Category: Drugs & Pharmacology Authors: Mohd A, Rupasinghe HPV Tags: Curr Drug Metab Source Type: research

Association of Metronidazole with Cancer: A Potential Risk Factor or Inconsistent Deductions?
Abstract Metronidazole is a synthetic derivative of nitroimidazole that has been widely used for the treatment of several bacterial and protozoal parasitic infections including trichomoniasis, amoebiasis, giardiasis, liver abscess, acute ulcerative gingivitis, syphilis and tropical phagedena. In addition to its toxicity in the gastrointestinal tract and central/peripheral nervous system, metronidazole has been reported to cause mucosal imbalance by affecting the expression of mucin (Muc2 gene), which is responsible to form an insoluble mucous barrier that protects the gut lumen from microbial colonization. Since m...
Source: Current Drug Metabolism - March 29, 2018 Category: Drugs & Pharmacology Authors: Adil M, Iqbal W, Adnan F, Wazir S, Khan I, Khayam MU, Kamal MA, Ahmad S, Ahmad J, Khan IN Tags: Curr Drug Metab Source Type: research

Pasireotide - mechanism of action and clinical applications.
Abstract Pasireotide (SOM230) is a multi-receptor ligand somatostatin analogue (SSA) developed as the successor of the first-generation SSAs. Currently, pasireotide is recommended for the treatment of patients with Cushing's disease in whom surgery was unsuccessful, and patients with acromegaly who either remain uncontrolled after surgical therapy or in whom tumor resection is not possible. Phase II and III clinical trials have shown pasireotide efficacy in these diseases, with a similar rate of adverse events when compared with first-line SSA, although higher incidence of hyperglycemia has been observed. Pasireot...
Source: Current Drug Metabolism - March 27, 2018 Category: Drugs & Pharmacology Authors: Sawicka-Gutaj N, Owecki M, Ruchala M Tags: Curr Drug Metab Source Type: research

Kidney-on-a-Chip: a New Technology for Predicting Drug Efficacy, Interactions, and Drug-induced Nephrotoxicity.
Abstract The kidneys play a pivotal role in most drug-removal processes and are important when evaluating drug safety. Kidney dysfunction resulting from various drugs is an important issue in clinical practice and during the drug development process. Traditional in vivo animal experiments are limited with respect to evaluating drug efficacy and nephrotoxicity due to discrepancies in drug pharmacokinetics and pharmacodynamics between humans and animals, and static cell culture experiments cannot fully reflect the actual microphysiological environment in humans. A kidney-on-a-chip is a microfluidic device that allo...
Source: Current Drug Metabolism - March 8, 2018 Category: Drugs & Pharmacology Authors: Lee J, Kim S Tags: Curr Drug Metab Source Type: research

Regulation of Mammalian UDP-glucuronosyltransferases.
Abstract UDP-glucuronosyltransferases (UGTs) are a class of important phase II drug metabolizing enzymes (DMEs), playing essential roles in the homeostasis of endobiotics as well as the dispositional behavior of exogenous compounds. The expression and enzyme activity of UGTs are regulated by multiple dimensions of mechanisms and can be influenced by diverse factors. Thus, the intensive research of its regulatory network is pivotal for better understanding about the physiological, pathological, and therapeutic significance of UGTs. Despite the lag to the research in cytochrome P450s, extensive efforts have been mad...
Source: Current Drug Metabolism - March 7, 2018 Category: Drugs & Pharmacology Authors: Wang H, Cao G, Wang G, Hao H Tags: Curr Drug Metab Source Type: research

Therapeutic uses of HSP90 inhibitors in Non-Small Cell Lung Carcinoma (NSCLC).
CONCLUSION: The goal of this review is to present the data in support to the use of HSP90 inhibitors in NSCLC and to provide an overview of the on-going clinical trials involving new-generation HSP90 inhibitors. PMID: 29521219 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 7, 2018 Category: Drugs & Pharmacology Authors: Akram A, Khalil S, Halim SA Tags: Curr Drug Metab Source Type: research

Current therapeutic approaches for targeting inflammation in depression and cardiovascular disease.
CONCLUSION: Strategies that can mitigate this risk profile are highly needed in the clinical setting, and these particular group of drugs has the possibility of becoming increasingly important in treatment strategies aiming to improve both conditions. PMID: 29512447 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 5, 2018 Category: Drugs & Pharmacology Authors: Zuzarte P, Duong A, Figueira ML, Vitali AC, Scola G Tags: Curr Drug Metab Source Type: research

Frontier view on nanotechnological strategies for neuro-therapy.
Abstract Nanotechnology exploits materials and devices with a functional organization that has been engineered at the nanometre scale. The application of nanotechnology in neuroscience involves specific interactions with neurons and glial cells. This property is used for delivering drugs and other small molecules (such as genes, oligonucleotides and contrasting agents) across the blood brain barrier (BBB), an important requirement for delivering the drug successfully to the brain. Nanotechnology based approaches (NBA) favoured transcytosis-mediated delivery of nanoparticles to the brain by crossing the BBB. The la...
Source: Current Drug Metabolism - March 5, 2018 Category: Drugs & Pharmacology Authors: Azhar A, Zia Q, Ansari SA, Kamal MA, Alexiou A, Yarla NS, Ashraf GM Tags: Curr Drug Metab Source Type: research

Sodium Oxybate treatment in pediatric type 1 narcolepsy.
Abstract Narcolepsy type 1 (NT1) is a rare chronic neurologic disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hallucinations and disrupted nocturnal sleep, usually with onset during childhood/adolescence. Pediatric NT1 is associated with limitations on children's activities and achievements, especially poor performance at school, difficulty with peers due to disease symptoms and comorbidities including depression, obesity, and precocious puberty. NT1 disease is caused by the selective loss of hypocretin-producing neurons in the lateral hypothalamus, most probably related to an a...
Source: Current Drug Metabolism - March 5, 2018 Category: Drugs & Pharmacology Authors: Moresco M, Pizza F, Antelmi E, Plazzi G Tags: Curr Drug Metab Source Type: research

Pharmacokinetics, Metabolism, Distribution and Permeability of Nanomedicine.
Conclusion Nanomedicine is increasingly becoming important in the treatment of diseases and diagnosis. Size of the particle plays an important role. As the particle size decreases its effect to cure the disease increases. Pharmacokinetics, bioavailability, half-life, metabolism, biodistribution and permeability of nanomedicine were found to be better than that of microsized drugs. In Vitro and In Vivo ADME (Absorption, Distribution, Metabolism and Excretion) studies are mandatory for pharmaceutical organic drugs. Similarly, nanomaterials should be subjected through both in vitro and in vivo ADME studies. Thus, nanomedicine...
Source: Current Drug Metabolism - March 5, 2018 Category: Drugs & Pharmacology Authors: Ravindran S, Suthar JK, Rokade R, Deshpande P, Singh P, Pratinidhi A, Khambadkhar R, Utekar S Tags: Curr Drug Metab Source Type: research

Potentiating effect of ethnomedicinal plants against proliferation on different cancer cell lines.
Abstract There is a long history of traditional medicine for serving world population. For the prevention and treatment of cancer numerous medicinal herbs from entire world including India are being used traditionally. Whenever we talk about treatment of cancer, medicinal plants always have been on the top. For the prevention and treatment of cancer, herbal medicines have played an important role. Countless anticancer plants have been recognized with the help of innovative techniques including isolation and structure elucidation that implement their beneficial effect by increasing immunity of the body, inducing an...
Source: Current Drug Metabolism - March 5, 2018 Category: Drugs & Pharmacology Authors: Hussain T, Bajpai S, Saeed M, Kamal MA, Ashraf GM Tags: Curr Drug Metab Source Type: research

Formulations, Pharmacodynamic and Clinical Studies of Nanoparticles for Lung Cancer Therapy-An overview.
CONCLUSION: Nanoparticle delivery system for lung cancer therapy is still in its early stage and expecting numerous challenges. PMID: 29512452 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 5, 2018 Category: Drugs & Pharmacology Authors: Zheng D, Wang J, Guo S, Zhao Z, Wang F Tags: Curr Drug Metab Source Type: research

Medicinal Plants in Neurodegenerative Diseases: Perspective of Traditional Persian Medicine.
CONCLUSIONS: Medicinal plants used in traditional Persian medicine along with their related phytochemicals by affecting various neuropharmacological pathways can be considered as future drugs or adjuvant therapies with conventional pharmacotherapeutics; though, further clinical studies are necessary for confirmation of their safety and efficacy. PMID: 29512453 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 5, 2018 Category: Drugs & Pharmacology Authors: Farzaei MH, Shahpiri Z, Mehri MR, Bahramsoltani R, Rezaei M, Raeesdana A, Rahimi R Tags: Curr Drug Metab Source Type: research

A Systems Pharmacology Study for Deciphering Anti Depression Activity of Nardostachys jatamansi.
Conclusion This study shows that how N. jatamansi can effect on depression by multiple molecular targeting with multiple compounds. PMID: 29512454 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 5, 2018 Category: Drugs & Pharmacology Authors: Jalali S, Zarrinhaghighi A, Sadraei S, Ghasemi Y, Sakhteman A, Faridi P Tags: Curr Drug Metab Source Type: research

Phytotherapy for prevention of atherosclerosis-associated early cerebral ischemia.
CONCLUSION: Phytotherapy appears to have a great potential for cerebrovascular disease prevention, combining good safety profiles with pleiotropic effects on different mechanisms atherosclerosis-related cerebral ischemia development. PMID: 29512455 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 5, 2018 Category: Drugs & Pharmacology Authors: Kirichenko TV, Myasoedova VA, Sobenin IA, Orekhov AN Tags: Curr Drug Metab Source Type: research

A review of herbal remedies for Multiple sclerosis-like disorders in Traditional Persian Medicine (TPM).
Abstract Among various neurological disorders, multiple sclerosis (MS) is an expanding global immune-related inflammatory disease with complex etiologies. There is increasing demand for the use and administration of natural medicaments for this disorder. Traditional Persian medicine (TPM) is a school of medicine and a medicinal plants-based resource for clinical studies put forward by Persian scholars. This paper aims to gather and study the effectiveness of all medicinal plants from the most popular Persian pharmacopeias. Five main Persian pharmacopeias from the 9th to the 18th century A.D. have been studied to i...
Source: Current Drug Metabolism - March 5, 2018 Category: Drugs & Pharmacology Authors: Zarshenas MM, Ansari R, Dadbakhsh A, Mohammadi M Tags: Curr Drug Metab Source Type: research

Topical discoveries on multi-target approach to manage Alzheimer's Disease.
Abstract Alzheimer's disease (AD) is recognized as progressive multifaceted and multi-factorial neurodegenerative disorder which causes dementia among elderly people. Although, researchers in this field have put considerable efforts for the investigation of novel and appropriate therapeutic measures towards the cure of AD, unfortunately, no effective prevention therapy for this disease is available till date. In fact, various aspects involved in the onset and progression of AD are still disputed or uncovered. However, to achieve definite and direct cure of AD, researcher's attention has been drawn towards explorat...
Source: Current Drug Metabolism - March 5, 2018 Category: Drugs & Pharmacology Authors: Batool A, Kamal MA, Rizvi SMD, Rashid S Tags: Curr Drug Metab Source Type: research

Pharmacokinetic and Toxicological Characteristics of Tripterigium Glycosides and Their Derivatives.
Abstract Tripterigium wilfordii glycosides (TWG) demonstrate paramount bioactive effectiveness in the management of many autoimmune diseases, such as rheumatoid arthritis, psoriasis, and nephrotic syndrome. However, its side effects on the hepatic, nephrotic, reproductive, and cardiovascular systems have limited its immense therapeutic potentials. Triptolide (TP) and Celastrol (CL), the leading bioactive as well as toxic constituents of TWG, have been widely studied. These studies have documented the key mechanisms that trigger the toxic reactions and the precautionary measures that could prevent and reduce such r...
Source: Current Drug Metabolism - March 2, 2018 Category: Drugs & Pharmacology Authors: Du X, Nyagblordzro M, An L, Gao X, Du L, Wang Y, Ondieki G, Kikete S, He X Tags: Curr Drug Metab Source Type: research

An Insight on the Therapeutic Potential of Major Coffee Components.
In conclusion, more pre-clinical and clinical trials are recommended to investigate the safety profiles of these coffee components. PMID: 29512445 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 2, 2018 Category: Drugs & Pharmacology Authors: Islam MT, Tabrez S, Jabir NR, Ali M, Kamal MA, da Silva Araujo L, De Oliveira Santos JV, Da Mata AMOF, De Aguiar RPS, de Carvalho Melo Cavalcante AA Tags: Curr Drug Metab Source Type: research

A synopsis on the role of human papilloma virus infection in cervical cancer.
Abstract Cancer or abnormal growth of the cell is one of the major health problems of the world. There are about two hundred types of malignancies reported till date. In this review, a brief update on cancer, its causes and different types has been discussed along with updated statistics of patient's mortality. A brief overview of cervical cancer and its pathophysiology has been discussed with special emphasis on its causative agent, human papilloma virus (HPV). A brief introduction and update on genetics, molecular pathogenesis and prevalence of HPV and its role in cervical cancer have been added. This revie...
Source: Current Drug Metabolism - March 2, 2018 Category: Drugs & Pharmacology Authors: Saeed M, Alshammari FD, Alam MJ, Sarim KM, Ahmad K, Hussain T, Khan M, Kamal MA, Ashraf GM Tags: Curr Drug Metab Source Type: research

Plant-derived polyphenols in human health: biological activity, metabolites and putative molecular targets.
Abstract Edible plants such as Hibiscus sabdariffa, Lippia citriodora, Rosmarinus officinalis and Olea europaea, are rich in bioactive compounds that represent most of the phenolic compounds families and have exhibited potential benefits in human health. These plants have been commonly used in folk medicine for their potential therapeutic properties in human chronic diseases. Recent evidence on these plants leads to postulate that polyphenols may account for such effects. Nevertheless, the compounds or metabolites that are responsible for reaching the molecular targets are still unknown. Data based on studies that...
Source: Current Drug Metabolism - February 19, 2018 Category: Drugs & Pharmacology Authors: Olivares-Vicente M, Barrajon-Catalan E, Herranz-Lopez M, Segura-Carretero A, Joven J, Encinar JA, Micol V Tags: Curr Drug Metab Source Type: research

Real-time Monitoring of Nanoparticle-based Therapeutics: A Review.
Abstract With the development of nanomaterials, nanoparticle-based therapeutics have found increasing application in various fields, including clinical and basic medicine. Real-time monitoring of nanoparticle-based therapeutics is considered critical to both pharmacology and pharmacokinetics. In this review, we discuss the different methods of real-time monitoring of nanoparticle-based therapeutics comprising different types of nanoparticle carriers, such as metal nanoparticles, inorganic nonmetallic nanoparticles, biodegradable polymer nanoparticles, and biological nanoparticles. With technology development and a...
Source: Current Drug Metabolism - February 11, 2018 Category: Drugs & Pharmacology Authors: Han Q, Niu M, Zhong H, Wu Q Tags: Curr Drug Metab Source Type: research

Advances in nanostructure-mediated hyperthermia in tumor therapies.
Abstract Hyperthermia has been proposed as a promising treatment modality for its advantageous profiles such as mini/non-invasiveness, good tolerability, and cost-effectiveness. Quick development of nanotechnology in recent years has greatly broadened the application area of hyperthermia and endowed it with attractive new functions. Thermal sensitive nanostructures can absorb energy from an external source. They can control the therapeutic heating only in the targeted region without damage to normal tissues. They can also be loaded with therapeutic drugs and/or functionalized with imaging properties to construct m...
Source: Current Drug Metabolism - January 29, 2018 Category: Drugs & Pharmacology Authors: Dou JP, Zhou QF, Liang P, Yu J Tags: Curr Drug Metab Source Type: research

Cross-regulatory circuit between AHR and microbiota.
Abstract The gut microbes have a close symbiotic relationship with their host. Interactions between host and the microbiota affect the nutritional, immunological, and physiological status of the host. The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that mediates the toxicity of xenobiotics. Recently, the relationship between the gut microbiota and AHR has attracted the attention of many researchers. The AHR influences the intestinal microbiota population and mediates host-microbe homeostasis. Interestingly, the gut microbiota also produces ligands of AHR from bacterial metabolism and...
Source: Current Drug Metabolism - January 29, 2018 Category: Drugs & Pharmacology Authors: Ji J, Qu H Tags: Curr Drug Metab Source Type: research

Herbal immunomodulators, a remedial panacea for the designing and developing effective drugs and medicines: Current scenario and future prospects.
Abstract Constant exposure to various stressors, such as immune pressure, rapidly increasing population, deleterious changes in the ecosystem, climate change, infection with emerging and re-emerging pathogens, and fast-paced lifestyle, is a critical factor in the globally increasing incidences of immunocompromising health conditions, as well as stress. Synthetic chemotherapeutic agents, which are widely available in the commercial market, may be highly efficacious, but most are immunosuppressive and exert many side effects. Undoubtedly, the pivotal characteristics of immunostimulants and immunomodulators in the ma...
Source: Current Drug Metabolism - January 29, 2018 Category: Drugs & Pharmacology Authors: Tiwari R, Latheef SK, Ahmed I, Iqbal HMN, Bule MH, Dhama K, Samad HA, Karthik K, Alagawany M, El-Hack MEA, Yatoo MI, Farag MR Tags: Curr Drug Metab Source Type: research

Medicinal and Therapeutic Potential of Herbs and Plant Metabolites / Extracts Countering Viral Pathogens - Current Knowledge and Future Prospects.
Abstract Recently, there has been a remarkable progress in the field of antiviral herbal therapy owing to increasing concerns about the development of drug resistance and limited advances in the field of antiviral drug discovery. In almost all countries, medicinal plants have been used widely throughout history for the treatment of diseases and infections as traditional healing remedies due to their broad therapeutic spectrum and minimal or no side effects. As synthetic antiviral drugs are not available against most of the viral agents, hence all possible efforts have been focused on the search for new drugs and c...
Source: Current Drug Metabolism - January 29, 2018 Category: Drugs & Pharmacology Authors: Dhama K, Karthik K, Khandia R, Munjal A, Tiwari R, Rana R, Khurana SK, Khan RU, Alagawany M, Farag MR, Dadar M, Joshi SK Tags: Curr Drug Metab Source Type: research

Pharmacokinetics, Pharmacodynamics and Pharmacogenetics of Tacrolimus in Kidney Transplantation.
Abstract Tacrolimus(Tac) is a first-line immunosuppressive drug used mainly after allogeneic organ transplant to reduce rejection. Tac is proved to be effective in preventing acute rejection, yet it has considerable toxicity and displays marked inter-individual variability in its pharmacokinetics(PK) and pharmacodynamics(PD). Established pharmacogenetics(PG) discoveries are being investigated on drug absorption, metabolism, disposition, excretion and response for better clinical application. The purpose of the present review is to picture the current status of Tac PG, and discuss the relationship between its PK an...
Source: Current Drug Metabolism - January 29, 2018 Category: Drugs & Pharmacology Authors: Yu M, Liu M, Zhang W, Ming Y Tags: Curr Drug Metab Source Type: research

Relationship between CNS and immunology, in relation to psychology.
Abstract Higher animals, especially the human beings have the privilege of employing advanced central nervous system (CNS) as well as the evolved immune system to ward off various onslaughts throughout their life. Alterations in inflammatory and neural regulatory pathways lead to several disorders that are now becoming the cause of concern across the world. Deregulation in bidirectional network, particularly in aging population, leads to several neurodegenerative diseases such as having dementia as a one of the major characteristics. Interestingly, research updates have signified the role of abrupt immune regulati...
Source: Current Drug Metabolism - January 29, 2018 Category: Drugs & Pharmacology Authors: Ashraf GM, Azhar A, Ali A, Rehan M, Zia Q, Owais M, Alexiou A, Rauf A, Ganash M, Kamal MA Tags: Curr Drug Metab Source Type: research

Hepatitis C Virus mediated metastasis in hepatocellular carcinoma as a therapeutic target for cancer management.
Abstract Hepatocellular carcinoma (HCC) is one of the most common causes of cancer associated deaths. The prognosis is relatively poor in cases where Hepatitis C Virus (HCV) is associated as its causative agent mainly due to increased risk of metastasis. Tumor metastasis can be defined as the transfer of cancer from one organ to another which is not directly connected to it. Metastasis is the major cause of all cancer related deaths. HCV infection is associated with expression of multiple pro-metastatic factors in HCC patients. Several HCV encoded proteins have been reported to directly induce pro-metastasis cellu...
Source: Current Drug Metabolism - January 28, 2018 Category: Drugs & Pharmacology Authors: Khera L, Paul C, Kaul R Tags: Curr Drug Metab Source Type: research

How to Control Asthma with Personalized Management: Where Do We Stand Now?
Abstract Asthma is one of the most significant diseases worldwide and causes overwhelming costs physically and economically. The heterogeneity of asthma has been a hot topic, and an increasing amount of research has been conducted on this issue. The study of asthma has revealed various groups of asthma patients who share phenotypic characteristics that naturally elicit the need for personalized asthma therapy. Clinical evidence has shown that a 'one size fits all' approach does not apply to all asthma patients because of the large variability in treatment responses to asthma medication. Attention should be given t...
Source: Current Drug Metabolism - January 28, 2018 Category: Drugs & Pharmacology Authors: Wang M, Yao Y, Jiang S, Tao F, Tang R, Sun J Tags: Curr Drug Metab Source Type: research

Kisspeptin and its effect on mammalian spermatogensis.
Abstract Kisspeptin and its receptor, GPR54, are regarded as key regulators of and catalysts for male puberty onset, and also fundamental gatekeepers of spermatogenesis in mammals. Consequently, the loss function of kisspeptin or GPR54 leads to a symptom of hypogonadotropic hypogonadism (HH) in human and HH accompanied by lower gonadotrophic hormone levels, smaller testes, impaired spermatogenesis and abnormal sexual maturation in mice. Besides its well- recognized functions in hypothalamus before and during puberty, accumulating data strongly support kisspeptin production in tests, and participation in somatic an...
Source: Current Drug Metabolism - January 28, 2018 Category: Drugs & Pharmacology Authors: Feng T, Bai J, Xu X, Liu Y Tags: Curr Drug Metab Source Type: research

Role of Interleukin 28B polymorphisms in response to Interferon based therapy for hepatitis C virus clearance.
Abstract Interleukin-28B (IL28B) locus on a human chromosomal region 19q13 is responsible for immune protection against viruses. IL28B in hepatitis C virus (HCV) infection determines the fate of infection towards causing spontaneous clearance or chronic liver infection. Choice of treatment in chronic hepatitis C infection includes use of direct acting antivirals, pegylated-interferon (PEG-IFN) or ribavirin (RBV) therapy. Interferon free regimens are also suggested to be useful in drug resistant patients. Genome-wide association studies (GWAS), comprehensive meta-analysis and independent case-control studies in dif...
Source: Current Drug Metabolism - January 28, 2018 Category: Drugs & Pharmacology Authors: Asthana M, Sahu SK, Kumar A, Mohanty S, Chakrabarti S, Das P, Chattopadhya NR, Chatterjee K, Singh SP, Rajasubramaniam S, Choudhuri T Tags: Curr Drug Metab Source Type: research

Effects of GHB on psychomotor and driving performance.
CONCLUSION: GHB causes cognitive and psychomotor impairment and risky driving behavior. Multiple aspects and variables are still waiting for clarification, such as the harmful potential of illicit preparations, the effect of precursors, impairing dosages. GHB (and its precursors) must be considered a substantial personal and public risk even in the absence of a clear dose-effects correlation. PMID: 29366411 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 23, 2018 Category: Drugs & Pharmacology Authors: Centola C, Giorgetti A, Zaami S, Giorgetti R Tags: Curr Drug Metab Source Type: research