Dermatokinetics: Advances and Experimental Models, Focus on Skin Metabolism
Curr Drug Metab. 2022 May 17. doi: 10.2174/1389200223666220517114004. Online ahead of print.ABSTRACTNumerous dermal contact products, such as drugs or cosmetics, are applied on the skin, the first protective barrier to their entrance into the organism. These products contain various xenobiotic molecules that can penetrate the viable epidermis. Many studies have shown that keratinocyte metabolism could affect their behavior by biotransformation. While aiming for detoxification, toxic metabolites can be produced. These metabolites may react with biological macromolecules often leading to sensitization reactions. After passin...
Source: Current Drug Metabolism - May 19, 2022 Category: Drugs & Pharmacology Authors: Paul Quantin Mathilde Stricher Sophie Catoire Herv é Ficheux Christophe Egles Source Type: research

Comparison of Sweated and Non-Sweated Ethanol Extracts of Salvia miltiorrhiza Bge. (Danshen) Effects on Human and rat Hepatic UDP-Glucuronosyltransferase and Preclinic Herb-Drug Interaction Potential Evaluation
CONCLUSION: The effects of two processed DEE on hepatic UGT enzyme expression and activity were different. Accordingly, the combined usage of related UGTs substrates with DEE and its monomer components preparations may call for caution, depending on the drug's exposure-response relationship and dose adjustment. Besides, it is vital to pay attention to the distinction between sweated and non-sweated Danshen in clinic, which exerted an important influence on its pharmacological activity.PMID:35585828 | DOI:10.2174/1389200223666220517115845 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 19, 2022 Category: Drugs & Pharmacology Authors: Jie Liu Yun Shi Chengyuan Wu Bangzhen Hong Daiyin Peng Nianjun Yu Guokai Wang Lei Wang Weidong Chen Source Type: research

Dermatokinetics: Advances and Experimental Models, Focus on Skin Metabolism
Curr Drug Metab. 2022 May 17. doi: 10.2174/1389200223666220517114004. Online ahead of print.ABSTRACTNumerous dermal contact products, such as drugs or cosmetics, are applied on the skin, the first protective barrier to their entrance into the organism. These products contain various xenobiotic molecules that can penetrate the viable epidermis. Many studies have shown that keratinocyte metabolism could affect their behavior by biotransformation. While aiming for detoxification, toxic metabolites can be produced. These metabolites may react with biological macromolecules often leading to sensitization reactions. After passin...
Source: Current Drug Metabolism - May 19, 2022 Category: Drugs & Pharmacology Authors: Paul Quantin Mathilde Stricher Sophie Catoire Herv é Ficheux Christophe Egles Source Type: research

Comparison of Sweated and Non-Sweated Ethanol Extracts of Salvia miltiorrhiza Bge. (Danshen) Effects on Human and rat Hepatic UDP-Glucuronosyltransferase and Preclinic Herb-Drug Interaction Potential Evaluation
CONCLUSION: The effects of two processed DEE on hepatic UGT enzyme expression and activity were different. Accordingly, the combined usage of related UGTs substrates with DEE and its monomer components preparations may call for caution, depending on the drug's exposure-response relationship and dose adjustment. Besides, it is vital to pay attention to the distinction between sweated and non-sweated Danshen in clinic, which exerted an important influence on its pharmacological activity.PMID:35585828 | DOI:10.2174/1389200223666220517115845 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 19, 2022 Category: Drugs & Pharmacology Authors: Jie Liu Yun Shi Chengyuan Wu Bangzhen Hong Daiyin Peng Nianjun Yu Guokai Wang Lei Wang Weidong Chen Source Type: research

Dermatokinetics: Advances and Experimental Models, Focus on Skin Metabolism
Curr Drug Metab. 2022 May 17. doi: 10.2174/1389200223666220517114004. Online ahead of print.ABSTRACTNumerous dermal contact products, such as drugs or cosmetics, are applied on the skin, the first protective barrier to their entrance into the organism. These products contain various xenobiotic molecules that can penetrate the viable epidermis. Many studies have shown that keratinocyte metabolism could affect their behavior by biotransformation. While aiming for detoxification, toxic metabolites can be produced. These metabolites may react with biological macromolecules often leading to sensitization reactions. After passin...
Source: Current Drug Metabolism - May 19, 2022 Category: Drugs & Pharmacology Authors: Paul Quantin Mathilde Stricher Sophie Catoire Herv é Ficheux Christophe Egles Source Type: research

Comparison of Sweated and Non-Sweated Ethanol Extracts of Salvia miltiorrhiza Bge. (Danshen) Effects on Human and rat Hepatic UDP-Glucuronosyltransferase and Preclinic Herb-Drug Interaction Potential Evaluation
CONCLUSION: The effects of two processed DEE on hepatic UGT enzyme expression and activity were different. Accordingly, the combined usage of related UGTs substrates with DEE and its monomer components preparations may call for caution, depending on the drug's exposure-response relationship and dose adjustment. Besides, it is vital to pay attention to the distinction between sweated and non-sweated Danshen in clinic, which exerted an important influence on its pharmacological activity.PMID:35585828 | DOI:10.2174/1389200223666220517115845 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 19, 2022 Category: Drugs & Pharmacology Authors: Jie Liu Yun Shi Chengyuan Wu Bangzhen Hong Daiyin Peng Nianjun Yu Guokai Wang Lei Wang Weidong Chen Source Type: research

Dermatokinetics: Advances and Experimental Models, Focus on Skin Metabolism
Curr Drug Metab. 2022 May 17. doi: 10.2174/1389200223666220517114004. Online ahead of print.ABSTRACTNumerous dermal contact products, such as drugs or cosmetics, are applied on the skin, the first protective barrier to their entrance into the organism. These products contain various xenobiotic molecules that can penetrate the viable epidermis. Many studies have shown that keratinocyte metabolism could affect their behavior by biotransformation. While aiming for detoxification, toxic metabolites can be produced. These metabolites may react with biological macromolecules often leading to sensitization reactions. After passin...
Source: Current Drug Metabolism - May 19, 2022 Category: Drugs & Pharmacology Authors: Paul Quantin Mathilde Stricher Sophie Catoire Herv é Ficheux Christophe Egles Source Type: research

Comparison of Sweated and Non-Sweated Ethanol Extracts of Salvia miltiorrhiza Bge. (Danshen) Effects on Human and rat Hepatic UDP-Glucuronosyltransferase and Preclinic Herb-Drug Interaction Potential Evaluation
CONCLUSION: The effects of two processed DEE on hepatic UGT enzyme expression and activity were different. Accordingly, the combined usage of related UGTs substrates with DEE and its monomer components preparations may call for caution, depending on the drug's exposure-response relationship and dose adjustment. Besides, it is vital to pay attention to the distinction between sweated and non-sweated Danshen in clinic, which exerted an important influence on its pharmacological activity.PMID:35585828 | DOI:10.2174/1389200223666220517115845 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 19, 2022 Category: Drugs & Pharmacology Authors: Jie Liu Yun Shi Chengyuan Wu Bangzhen Hong Daiyin Peng Nianjun Yu Guokai Wang Lei Wang Weidong Chen Source Type: research

Dermatokinetics: Advances and Experimental Models, Focus on Skin Metabolism
Curr Drug Metab. 2022 May 17. doi: 10.2174/1389200223666220517114004. Online ahead of print.ABSTRACTNumerous dermal contact products, such as drugs or cosmetics, are applied on the skin, the first protective barrier to their entrance into the organism. These products contain various xenobiotic molecules that can penetrate the viable epidermis. Many studies have shown that keratinocyte metabolism could affect their behavior by biotransformation. While aiming for detoxification, toxic metabolites can be produced. These metabolites may react with biological macromolecules often leading to sensitization reactions. After passin...
Source: Current Drug Metabolism - May 19, 2022 Category: Drugs & Pharmacology Authors: Paul Quantin Mathilde Stricher Sophie Catoire Herv é Ficheux Christophe Egles Source Type: research

Comparison of Sweated and Non-Sweated Ethanol Extracts of Salvia miltiorrhiza Bge. (Danshen) Effects on Human and rat Hepatic UDP-Glucuronosyltransferase and Preclinic Herb-Drug Interaction Potential Evaluation
CONCLUSION: The effects of two processed DEE on hepatic UGT enzyme expression and activity were different. Accordingly, the combined usage of related UGTs substrates with DEE and its monomer components preparations may call for caution, depending on the drug's exposure-response relationship and dose adjustment. Besides, it is vital to pay attention to the distinction between sweated and non-sweated Danshen in clinic, which exerted an important influence on its pharmacological activity.PMID:35585828 | DOI:10.2174/1389200223666220517115845 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 19, 2022 Category: Drugs & Pharmacology Authors: Jie Liu Yun Shi Chengyuan Wu Bangzhen Hong Daiyin Peng Nianjun Yu Guokai Wang Lei Wang Weidong Chen Source Type: research

Dermatokinetics: Advances and Experimental Models, Focus on Skin Metabolism
Curr Drug Metab. 2022 May 17. doi: 10.2174/1389200223666220517114004. Online ahead of print.ABSTRACTNumerous dermal contact products, such as drugs or cosmetics, are applied on the skin, the first protective barrier to their entrance into the organism. These products contain various xenobiotic molecules that can penetrate the viable epidermis. Many studies have shown that keratinocyte metabolism could affect their behavior by biotransformation. While aiming for detoxification, toxic metabolites can be produced. These metabolites may react with biological macromolecules often leading to sensitization reactions. After passin...
Source: Current Drug Metabolism - May 19, 2022 Category: Drugs & Pharmacology Authors: Paul Quantin Mathilde Stricher Sophie Catoire Herv é Ficheux Christophe Egles Source Type: research

Comparison of Sweated and Non-Sweated Ethanol Extracts of Salvia miltiorrhiza Bge. (Danshen) Effects on Human and rat Hepatic UDP-Glucuronosyltransferase and Preclinic Herb-Drug Interaction Potential Evaluation
CONCLUSION: The effects of two processed DEE on hepatic UGT enzyme expression and activity were different. Accordingly, the combined usage of related UGTs substrates with DEE and its monomer components preparations may call for caution, depending on the drug's exposure-response relationship and dose adjustment. Besides, it is vital to pay attention to the distinction between sweated and non-sweated Danshen in clinic, which exerted an important influence on its pharmacological activity.PMID:35585828 | DOI:10.2174/1389200223666220517115845 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 19, 2022 Category: Drugs & Pharmacology Authors: Jie Liu Yun Shi Chengyuan Wu Bangzhen Hong Daiyin Peng Nianjun Yu Guokai Wang Lei Wang Weidong Chen Source Type: research

Impact of POR*28 Variant on Tacrolimus Pharmacokinetics in Kidney Transplant Patients with Different CYP3A5 Genotypes
CONCLUSION: In the studied population, the variant allelic POR*28 was significantly associated with lower TAC dose requirements and higher Co/D ratio in the first-month post-transplant. However, the effects of this polymorphism on the CYP3A5 enzyme activity were not observed.PMID:35578867 | DOI:10.2174/1389200223666220516094226 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 17, 2022 Category: Drugs & Pharmacology Authors: Janaina B F Everton Fernando J B Patr ício Manuel S Faria Teresa C A Ferreira Natalino Salgado Filho Gyl E B Silva Elen A Rom ão Marcelo Magalh ães Source Type: research

Impact of POR*28 Variant on Tacrolimus Pharmacokinetics in Kidney Transplant Patients with Different CYP3A5 Genotypes
CONCLUSION: In the studied population, the variant allelic POR*28 was significantly associated with lower TAC dose requirements and higher Co/D ratio in the first-month post-transplant. However, the effects of this polymorphism on the CYP3A5 enzyme activity were not observed.PMID:35578867 | DOI:10.2174/1389200223666220516094226 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 17, 2022 Category: Drugs & Pharmacology Authors: Janaina B F Everton Fernando J B Patr ício Manuel S Faria Teresa C A Ferreira Natalino Salgado Filho Gyl E B Silva Elen A Rom ão Marcelo Magalh ães Source Type: research

Structural Modeling of Drosophila melanogaster Gut Cytochrome P450s and Docking Comparison of Fruit Fly Gut and Human Cytochrome P450s
Curr Drug Metab. 2022 May 11. doi: 10.2174/1389200223666220511162234. Online ahead of print.ABSTRACTDrosophila melanogaster is a prominent model organism in developmental biology research and in studies related to pathophysiological conditions like cancer and Alzheimer's disease. The fruit fly gut contains several cytochrome P450s (CYP450s) which have central roles in Drosophila development and in the normal physiology of the gut. Since the crystal structures of these proteins have not been deciphered yet, we modeled the structure of 29 different D. melanogaster gut CYP450s using Prime (Schrödinger). The sequences of chos...
Source: Current Drug Metabolism - May 13, 2022 Category: Drugs & Pharmacology Authors: Vijay Nirusimhan Daniel Andrew Gideon Abhinav Parashar Sangavi Jeyachandran Jeyakanthan Jeyaraman Gowthamkumar Subbaraj Langeswaran Kulanthaivel Source Type: research