Differential impacts of azole antifungal drugs on the pharmacokinetic profiles of dasatinib in rats by LC-MS-MS.
CONCLUSION: These data indicated that ketoconazole, posaconazole and voriconazole should be cautiously co-administered with dasatinib or close therapeutic drug monitoring of dasatinib concentration, which might cause the drug-drug interaction. PMID: 33092505 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - October 22, 2020 Category: Drugs & Pharmacology Authors: Luo X, Xue X, Li T, Zhang Y, Huang L, Cheng G Tags: Curr Drug Metab Source Type: research

Tumor angiogenesis and VEGFR-2: mechanism, pathways and current biological therapeutic interventions.
CONCLUSIONS: An improved or alternative treatment is needed shortly that would have a higher survival rate with least side effects. Innovative strategies including personalized medicine, Nano-medicine, cancer immunotherapy have also been outlined as an alternative treatment therapy with discussion about needed advancements and improvements in their implementation methods. PMID: 33076807 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - October 19, 2020 Category: Drugs & Pharmacology Authors: Shah AA, Kamal MA, Akhtar S Tags: Curr Drug Metab Source Type: research

Natural Compounds as Source of Aldose Reductase (AR) Inhibitors for the Treatment of Diabetic Complications: A Mini Review.
CONCLUSION: Natural inhibitors of have AR appeared as harmless pharmacological agents for controlling diabetic complications. The detailed literature throughout this article shows the significance of herbal extracts and phytochemicals as prospective useful AR inhibitors in treating diabetic complications. PMID: 33069193 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - October 16, 2020 Category: Drugs & Pharmacology Authors: Grewal AS, Thapa K, Kanojia N, Sharma N, Singh S Tags: Curr Drug Metab Source Type: research

Different Effects of Polymorphic Flavin-containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-related Disease in a General Population in Japan.
CONCLUSION: The P450 2A6 wild-type allele may be a possible candidate biomarker for arteriosclerosis in a general population in Japan with a variety of dietary habits. PMID: 33038907 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - October 9, 2020 Category: Drugs & Pharmacology Authors: Uraoka M, Shimizu M, Kuwajima Y, Mizugaki A, Yokoyama H, Mure K, Yamazaki H Tags: Curr Drug Metab Source Type: research

The current application of LC-MS/MS in pharmacokinetics of traditional Chinese medicines (recent three years): A systematic review.
Conclusion: Although LC-MS/MS can be used for high-throughput analysis, the characterization of in vivo processes of TCM is still has a long way. With the advantages of high sensitivity, high specificity and simple operation, the increasingly mature LC-MS/MS technology will play an important role in the PK of TCM. PMID: 33038908 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - October 9, 2020 Category: Drugs & Pharmacology Authors: Wang Y, Zhang L, Gu S, Yin Z, Shi Z, Wang P, Xu C Tags: Curr Drug Metab Source Type: research

Biosurfactants as a novel additive in pharmaceutical formulations: Current trends and future implications.
CONCLUSION: Biosurfactants exhibit good biomedicine and additives properties that can be used in developing novel drug delivery systems. However, more research should be driven due to lack of comprehensive toxicity testing and high production cost which limits their use. PMID: 33032505 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - October 8, 2020 Category: Drugs & Pharmacology Authors: Thakur S, Singh A, Sharma R, Aurora R, Jain SK Tags: Curr Drug Metab Source Type: research

Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China.
CONCLUSION: Antibiotic-perpetrated drug interactions, involving P450 enzyme inhibition, have been reported for four lipophilic antibacterials (ciprofloxacin, erythromycin, trimethoprim, and trimethoprim-sulfamethoxazole) and three lipophilic antifungals (fluconazole, itraconazole, and voriconazole). In addition, seven hydrophilic antibacterials (ceftriaxone, cefamandole, piperacillin, penicillin G, amikacin, metronidazole, and linezolid) inhibit drug transporters in vitro. Despite no reported clinical PK drug interactions with the transporters, caution is advised in the use of these antibacterials. Eight hydrophilic antiba...
Source: Current Drug Metabolism - September 28, 2020 Category: Drugs & Pharmacology Authors: Yu X, Chu Z, Li J, He R, Wang Y, Cheng C Tags: Curr Drug Metab Source Type: research

Directing the antiretroviral drugs to the brain reservoir: A nanoformulation approach for NeuroAIDS.
CONCLUSION: The futuristic holistic nanotechnology methods, however should focus of increasing the drug trafficking and permeability across the BBB to ameliorate the therapeutic effect of ARV drugs. Additionally the domain warrants clinical studies to be undertaken to make the technique commercially viable and a success for upheaval of the treatment strategy. PMID: 32964821 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - September 22, 2020 Category: Drugs & Pharmacology Authors: Nabi B, Rehman S, Pottoo FH, Baboota S, Ali J Tags: Curr Drug Metab Source Type: research

Current treatment options for HCC: from pharmacokinetics to efficacy and adverse events in liver cirrhosis.
CONCLUSIONS: The new scenario of systemic HCC therapy includes more active drugs with different metabolic pathways and different liver adverse events. Clinical and pharmacological studies providing more data on the safety of these molecules are urgently needed. PMID: 32957880 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - September 17, 2020 Category: Drugs & Pharmacology Authors: Galati G, Massimo Vainieri AF, Maria Fulgenzi CA, Di Donato S, Silletta M, Gallo P, Onorato A, Vespasiani-Gentilucci U, Picardi A Tags: Curr Drug Metab Source Type: research

Toward Greater Insights on Applications of Modeling and Simulation in Pregnancy.
Abstract Pregnant women are often excluded from routine clinical trials. Consequently, appropriate dosing regimens for majority of drugs are unknown in this population, which may lead to unexpected safety issue or insufficient efficacy in this un-studied population. Establishing evidence through the conduct of clinical studies in pregnancy is still a challenge. In recent decades, physiologically-based pharmacokinetic (PBPK) modeling has proven to be useful to support dose selection under various clinical scenarios, such as renal and/or liver impairment, drug-drug interactions, and extrapolation from adult to child...
Source: Current Drug Metabolism - September 6, 2020 Category: Drugs & Pharmacology Authors: Song L, Cui C, Zhou Y, Dong Z, Yu Z, Xu Y, Zhou T, Abduljalil K, Han H, Li L, Yang J, Zhao Y, Li H, Liu D Tags: Curr Drug Metab Source Type: research

Assessment of the physicochemical properties and stability for pharmacokinetic prediction of pyrazinoic acid derivatives.
CONCLUSION: The results bring favorable perspectives for the future development of the evaluated compounds and other pyrazinoic acid derivatives. PMID: 32895039 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - September 6, 2020 Category: Drugs & Pharmacology Authors: Franchin TB, Ulian Silva BC, DeGrandis RA, Corrêa MF, de Queiroz Aranha CMS, Fernandes JPS, Campos ML, Peccinini RG Tags: Curr Drug Metab Source Type: research

In Silico ADME-T Evaluation of Natural DPP-IV Inhibitors for Rational Drug Design against Diabetes.
CONCLUSION: This assessment provides useful insight into the future development of novel drugs for the treatment of diabe-tes mellitus.. PMID: 32875983 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 31, 2020 Category: Drugs & Pharmacology Authors: Singla RK, Shen B Tags: Curr Drug Metab Source Type: research

Bibliometric Analysis of Current Drug Metabolism: The Twenty Years Anniversary From 2000-2019.
CONCLUSION: The data confirms that CDM showed a continuous growth in the number of publications and citations. However significant measures are needed to make overall progress and improve the rankings in relevant categories. PMID: 32851957 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 24, 2020 Category: Drugs & Pharmacology Authors: Hassan W, Kamdem JP, Kamal MA, da Rocha JBT Tags: Curr Drug Metab Source Type: research

Improved Therapeutic Efficacy of Topotecan Against A549 Lung Cancer Cells with Folate-targeted Topotecan Liposomes.
CONCLUSION: The folate-targeted topotecan liposomes are effective drug delivery systems and can be easily modified with folate, enabling the targeted liposomes to deliver topotecan to lung cancer cells and kill them, which could be used as potential carriers for lung chemotherapy. PMID: 32851958 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 19, 2020 Category: Drugs & Pharmacology Authors: Zhang J, Shi W, Xue G, Ma Q, Cui H, Zhang L Tags: Curr Drug Metab Source Type: research

Risk assessment of veterinary drug residues in meat products.
This article explains the necessity of risk assessment for veterinary drug residues in meat products, describes the principles and functions of risk assessment, then summarizes the risk assessment process of veterinary drug residues, and then outlines the qualitative and quan-titative risk assessment methods used in this field. We propose the establishment of a new meat product safety supervision model with a view to improve the current meat product safety supervision system. PMID: 32838714 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 19, 2020 Category: Drugs & Pharmacology Authors: Zhang H, Chen Q, Niu B Tags: Curr Drug Metab Source Type: research

Research Progress of Herbal Medicines on Drug Metabolizing Enzymes: Consideration Based on Toxicology.
Abstract The clinical application of herbal medicines is increasing, but there is still a lack of comprehensive safety data and in-depth research into mechanisms of action.The composition of herbal medicines is complex, with each herb containing a variety of chemical components. Each of these components may affect the activity of metabolizing enzymes, which may lead to herb-drug interactions. It has been reported that the combined use of herbs and drugs can produce some unexpected interactions. Therefore, we have reviewed the progress of research on safety issues caused by the effects of herbs on metabolizing enzy...
Source: Current Drug Metabolism - August 18, 2020 Category: Drugs & Pharmacology Authors: Wang S, Li W, Yang J, Yang Z, Yang C, Jin H Tags: Curr Drug Metab Source Type: research

A HPLC-DAD-MS/MS Method for Simultaneous Determination of Six Active Ingredients of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in Rat Plasma and Its Application to Pharmacokinetic Studies.
CONCLUSION: Linear pharmacokinetic characteristics were observed for the six active ingredients after intravenous infusion administration in rats, within the dose range examined here. In summary, our study proposed a HPLC-DAD-MS/MS method in the simultaneous determination of multiple ingredients, and demonstrated its applicability in pharmacokinetic studies. PMID: 32819255 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 18, 2020 Category: Drugs & Pharmacology Authors: Pan J, Zhang L, Xiong D, Li B, Qu H Tags: Curr Drug Metab Source Type: research

Recent Advances in Treatment of Childhood Obesity.
Abstract Childhood obesity has assumed epidemic proportions and is currently one of the most widespread public health problems. Many are the factors involved in the pathogenesis of excess weight with interactions between genetic, environmental and biological factors and therefore, also the therapeutic approach must be multidisciplinary and multidimensional. In this review of the literature, we report the contiguity of childhood obesity with eating disorders and the importance of involving the family context in order to induce stable lifestyle changes, both in relation to dietary and nutritional habits, but also in...
Source: Current Drug Metabolism - August 16, 2020 Category: Drugs & Pharmacology Authors: Milano W, Ambrosio P, Carizzone F, Di Munzio W, De Biasio V, Capasso A Tags: Curr Drug Metab Source Type: research

A Review: Effects of macrolides on CYP450 enzymes.
This article summarizes some published applications of the influence of macrolides on CYP450 and the DDIs of macrolides caused by CYP450. And the article may subsequently guides the use drugs of rationally in clinical trials. To a certain extent, poisoning caused by adverse drug interactions can be avoided. Unreasonable use of macrolide antibiotics may cause the residue of macrolide antibiotics in animal-origin food. It is unhealthy for people to eat food with macrolide antibiotic residues. So it is of great significance to guarantee the food safety and the health of consumers by the rational use of macrolides. This review...
Source: Current Drug Metabolism - August 16, 2020 Category: Drugs & Pharmacology Authors: Zhang L, Xu X, Badawy S, Ihsan A, Liu Z, Xie C, Wang X, Tao Y Tags: Curr Drug Metab Source Type: research

Role of Glucose Transporters in Drug Membrane Transport.
CONCLUSION: The membrane transport mechanism of some glycoside drugs may be related to glucose transporters. Glucose modification may improve the oral bioavailability of drugs or achieve targeted drug delivery. PMID: 32778021 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 9, 2020 Category: Drugs & Pharmacology Authors: Wang X, Guo K, Huang B, Lin Z, Cai Z Tags: Curr Drug Metab Source Type: research

New ultra low volume bowel preparation and overview of existing bowel preparations.
CONCLUSION: It is important to consider patient preferences, co-morbidities and tolerability and efficacy and side effect profiles when choosing bowel prep for patients undergoing colonoscopy. New ultra low bowel prep showed promising results in initial clinical trials but further real world post marketing data will inform its value in clinical practice. PMID: 32778022 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 8, 2020 Category: Drugs & Pharmacology Authors: Htet H, Segal J Tags: Curr Drug Metab Source Type: research

Study on the Plasma Protein Binding Rate and Compatibility Regularity of the Constituents Migrating to Blood of Simiao Yong'an Decoction.
CONCLUSIONS: This study explores the effects of compound compatibility on effective components from the perspective of plasma protein binding by high-performance liquid chromatography combined with equilibrium dialysis method, and lays a foundation for clarifying the compatibility rule of Simiao Yong'an Decoction and also provides a new idea for the study of compatibility of traditional Chinese medicine formulas. PMID: 32735517 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 30, 2020 Category: Drugs & Pharmacology Authors: Yu X, Jiao Q, Jiang Y, Guo S, Zhang W, Liu B Tags: Curr Drug Metab Source Type: research

Application of Machine Learning on Drug Target Discovery.
Abstract Drug target discovery is a critical step in drug development. It is the basis of modern drug development to deter-mine the target molecules related to specific diseases in advance. Predicting the drug target by computational methods saves a lot of financial and material resources than in vitro experiments, thereby a number of computational methods are designed for drug target discovery. Recently, machine learning (ML) methods have developed rapidly in biomedicine. In this paper, we present an overview of drug target discovery methods based on machine learning. Due to some machine learning meth-ods integra...
Source: Current Drug Metabolism - July 27, 2020 Category: Drugs & Pharmacology Authors: Gao D, Chen Q, Zeng Y, Jiang M, Zhang Y Tags: Curr Drug Metab Source Type: research

Germacrone: A potent secondary metabolite with therapeutic potential in metabolic diseases, cancer and viral infections.
Abstract Natural products, an infinite reserve of bioactive molecules, will continue to serve humans as an important source of therapeutic agents. Germacrone is a bioactive natural compound found in the traditional medicinal plants of family Zingi-beraceae.This multifaceted chemical entity has become a point of focus during recent years due to its numerous pharmaco-logical applications e.g., anticancer, anti-inflammatory, antiviral, antioxidant, anti-adipogenic, anti-androgenic, antimicrobi-al, insecticidal, and neuroprotective properties. Germacrone is an effective inducer of cell cycle arrest and apoptosis in va...
Source: Current Drug Metabolism - July 27, 2020 Category: Drugs & Pharmacology Authors: Riaz A, Rasul A, Kanwal N, Hussain G, Shah MA, Sarfraz I, Ishfaq R, Batool R, Rukhsar F, Adem Ş Tags: Curr Drug Metab Source Type: research

Lipid carriers mediated targeted delivery of nutraceuticals: Challenges, role of blood brain barrier and promises of nanotechnology based ap-proaches in neuronal disorders.
Abstract Despite all significant research in discovering new therapeuticals, there has been an alarming rate of reported neurological disorders. However, the delivery of these neurotherapeuticals within the brain region is still a significant chal-lenge in the clinical management of neuronal disorders. Here, characteristic of the blood-brain barrier and blood-cerebrospinal fluid barrier serves the purpose of a physiological barrier to restrict the passage of systemic bioavailable neu-rotherapeuticals inside the brain, owing to low permeability and drug localization issues. The major advantage of such lipid-based d...
Source: Current Drug Metabolism - July 27, 2020 Category: Drugs & Pharmacology Authors: Aslam M, Javed MN, Deeb HH, Nicola MK, Sabir AM, Hasnain MS, Alam MS, Waziri A Tags: Curr Drug Metab Source Type: research

Effects of Montmorillonite on Growth Performance, Serum Biochemistry and Oxidative Stress of Red-crowned Crane (Grus japonensis) fed mycotoxin-contaminated feed.
CONCLUSIONS: Taken together, these findings suggested that the addition of dietary Mont is effective to improve the health of red-crowned crane. PMID: 32713330 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 25, 2020 Category: Drugs & Pharmacology Authors: Liu D, Wu Q, Liu H, Lu C, Gu C, Kuca K, Wu W Tags: Curr Drug Metab Source Type: research

New devices for endoscopic treatments in gastroenterology: a narrative review.
bi LH Abstract Endoscopy is living period of continuous innovations in terms of image quality, endoscopes, post-processing software and lastly, application of Artificial Intelligence. Therapeutic boundaries have expanded widening the grey zone between endoscopy and surgery, increasing endoscopic approaches in clinical scenarios where, until a few years ago, surgery was the only option New scopes and accessories have made easier to access critical districts such as the biliary tree and the small bowel intestine. In the field of hepato-pancreato-biliary endoscopy (HPB), it is now possible to directly access the bili...
Source: Current Drug Metabolism - July 21, 2020 Category: Drugs & Pharmacology Authors: Furnari M, Telese A, Hann A, Lisotti A, Boškoski I, Eusebi LH Tags: Curr Drug Metab Source Type: research

The Metabolism and Pharmacokinetic of Rhein and Aurantio-obtusin.
CONCLUSION: This paper not only provides the pharmacokinetics of rhein and aurantio-obtusin, but also facilitates further study the metabolism of rhein and aurantio-obtusin. PMID: 32682364 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 17, 2020 Category: Drugs & Pharmacology Authors: Xiao SL, Guan LJ, Jiang RF, Wang XG, Li X, Cai W Tags: Curr Drug Metab Source Type: research

Current advances in drug delivery systems for capsule endoscopy.
CONCLUSION: Swallowable drug delivery systems for capsule endoscopy brings an entirely new approach for diagnostic and therapeutic methods in digestive diseases. PMID: 32682365 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 17, 2020 Category: Drugs & Pharmacology Authors: Lyutakov I, Penchev P Tags: Curr Drug Metab Source Type: research

Nanostructured Lipid Carriers (Nlcs): Nose-to-Brain Delivery and Theranostic Application.
CONCLUSION: The present review encompasses the in-depth discussion over the current state of the art of NLCs, nose-tobrain drug delivery perspectives and its theranostic application as useful tools for better management of various neurological disorders. In addition, pharmacokinetic consideration and toxicity concern is also discussed specifically for the NLCs system exploited in nose-to-brain delivery. PMID: 32682366 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 17, 2020 Category: Drugs & Pharmacology Authors: Ahmad J, Rizwanullah M, Amin S, Warsi MH, Ahmad MZ, Barkat MA Tags: Curr Drug Metab Source Type: research

The Influence of Different Disease States on Rituximab Pharmacokinetics.
CONCLUSION: Here we provide an overview of the complexities associated with rituximab pharmacokinetics and pharmacodynamics in different diseases. Although many influencing factors need to be verified in future studies, a better understanding of the relationships between pharmacokinetic and pharmacodynamic may assist in optimizing rituximab clinical practice. PMID: 32682367 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 17, 2020 Category: Drugs & Pharmacology Authors: Wang X, Du W, Zhang X, Li P Tags: Curr Drug Metab Source Type: research

Recent advances on antioxidant identification based on machine learning methods.
Abstract Antioxidants are molecules that can prevent damages to cells caused by free radicals. Recent studies also demonstrated that antioxidants play roles in preventing diseases. However, the number of known molecules with antioxidant activity is very small. Therefore, it's necessary to identify antioxidants from various resources. In the past several years, a series of computational methods have been proposed to identify antioxidants. In this review, we briefly summarized recent advances on computationally identifying antioxidants. The challenges and future perspectives for identifying antioxidants were also di...
Source: Current Drug Metabolism - July 17, 2020 Category: Drugs & Pharmacology Authors: Feng P, Feng L Tags: Curr Drug Metab Source Type: research

Application of Advanced Technologies in Natural Product Research: A re-view with special emphasis on ADMET profiling.
This article reviews the status, challenges, opportunities, and integration of advanced technologies in natural product research. Indeed, emphasis will be on current and futuristic direction towards the application of newer technologies in early-stage ADMET profiling of bioactive moieties from the natural sources. It can be expected that combinatorial approaches in ADMET profiling will fortify the Natural Product-based drug discovery in the near future. PMID: 32664837 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 13, 2020 Category: Drugs & Pharmacology Authors: Borah P, Hazarika S, Deka S, Venugopala KN, Nair AB, Attimarad M, Sreeharsha N, Mailavaram RP Tags: Curr Drug Metab Source Type: research

Mechanism of the Intestinal Absorption of Six Flavonoids from Zizyphi Spinosi Semen Across Caco-2 Cell Monolayer Model.
CONCLUSION: Our findings provide significant information for revealing the relationship between the intestinal absorption mechanism of flavonoids and its structure as well as laying a basis for the research of flavonoid preparations. PMID: 32664838 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 12, 2020 Category: Drugs & Pharmacology Authors: Song P, Xiao S, Zhang Y, Xie J, Cui X Tags: Curr Drug Metab Source Type: research

The current state of potential therapeutic modalities for glioblastoma multiforme: a clinical review.
Abstract Glioblastoma multiforme (GBM), as the most lethal brain tumor, continues to be incurable. Considering the high mortality rate of GBM, it is crucial to develop new treatment approaches. Conventional therapies, including maximal surgical resection, radiation therapy, and chemotherapy (typically temozolomide), have not led to significant changes in the survival rates of GBM patients. However, emerging modalities such as the use of tyrosine kinase inhibitors, mTOR inhibitors, NF-κB modulators, nitrosoureas, and immunotherapeutic agents have shown promise in improving GBM outcomes. In this context, we re...
Source: Current Drug Metabolism - July 12, 2020 Category: Drugs & Pharmacology Authors: Mohtashami E, Shafaei-Bajestani N, Mollazadeh H, Mousavi SH, Jalili-Nik M, Sahebkar A, Afshari AR Tags: Curr Drug Metab Source Type: research

Comparison of Bromhexine and its Active Metabolite - Ambroxol as Potential Analgesics Reducing Oxaliplatin-Induced Neuropathic Pain - Pharmacodynamic and Molecular Docking Studies.
CONCLUSION: The conversion of bromhexine to other than ambroxol active metabolites should be considered when interpreting some of its in vivo effects. Nav-blocking properties of bromhexine (and previously also predicted for ambroxol) might underlie their ability to attenuate pain caused by oxaliplatin. PMID: 32651960 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 10, 2020 Category: Drugs & Pharmacology Authors: Furgała-Wojas A, Kowalska M, Nowaczyk A, Fijałkowski Ł, Sałat K Tags: Curr Drug Metab Source Type: research

Updates on the Pharmacology of Chloroquine against Coronavirus Disease 2019 (COVID-19): A Perspective on its Use in the General and Geriatric Population.
CONCLUSION: According to literature reports, chloroquine has been proved to have anti-SARS-CoV-2 effect in vitro and the potential mechanism of chloroquine in vivo. Pharmacokinetic characteristics and DDIs study are helpful to guide rational drug use in general and geriatric patients. Although there have been reports of successful clinical application of chloroquine in treatment COVID-19,more clinical test data are still needed to prove its effectiveness and safety. PMID: 32651961 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 10, 2020 Category: Drugs & Pharmacology Authors: Yao X, Hou Z, Cui C, Zhang M, Tu S, Li H, Liu D Tags: Curr Drug Metab Source Type: research

Chemistry and antioxidant potential of phytoconstituents from Aegle marmelos fruit-shell.
CONCLUSION: Results showed that the hard shell of the Aegle marmelos fruit was a potent source for antioxidant compounds, which can be developed for therapeutic applications in control and management of metabolic diseases. PMID: 32651962 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 10, 2020 Category: Drugs & Pharmacology Authors: Chaubey A, Dubey AK Tags: Curr Drug Metab Source Type: research

Challenges in the Discovery of Novel Therapeutic Agents for Cancer Treatment (Part IV).
PMID: 32608350 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 3, 2020 Category: Drugs & Pharmacology Authors: Nagaraju GP, Kamal MA Tags: Curr Drug Metab Source Type: research

New Therapeutic Molecules and their Metabolism in Gastroenterology.
PMID: 32613914 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 3, 2020 Category: Drugs & Pharmacology Authors: Nakov R, Maida M, Ianiro G Tags: Curr Drug Metab Source Type: research

Annonaceae family alkaloids as agents against leishmaniasis: review and molecular docking evaluation.
This study presents an overview of the potential use of Annonaceae alkaloids to treat leishmaniasis and describes a molecular docking study examining 215 isoquinoline alkaloids. All selected compounds contain a bisbenzyltetrahydroisoquinoline, suggesting the affinity of this skeleton for the target. PMID: 32614742 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 1, 2020 Category: Drugs & Pharmacology Authors: Lorenzo VP, Scotti L, da Silva Almeida JRG, Scotti MT Tags: Curr Drug Metab Source Type: research

Exosomes as Targeted Drug Delivery Vehicles: Perspectives and Challenges.
PMID: 32614741 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 30, 2020 Category: Drugs & Pharmacology Authors: Liu D, Li X Tags: Curr Drug Metab Source Type: research

Hepatoprotective Role of Berberine on Doxorubicin Induced Hepatotoxici-ty - Involvement of Cyp.
CONCLUSION: It could be concluded that berberine may be an efficient anti-oxidant and immune modulator. It possesses low to moderate cytochrome modulatory potentials. PMID: 32586251 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 19, 2020 Category: Drugs & Pharmacology Authors: Sun B, Yang Y, He M, Jin Y, Cao X, Du X, Yang R Tags: Curr Drug Metab Source Type: research

Strong Association between Serotonin Transporter 5-HTTVNTR Variant and Psychoactive Substance (Nicotine) Use in the Turkish Cypriot Population.
Abstract BACKGROUND: The use of psychoactive substances is one of the most dangerous social problems worldwide. Nicotine dependence results from the interaction between neurobiological, environmental and genetic factors. Serotonin is a neurotransmitter that has a wide range of central nervous system activities. The serotonin transporter gene has been previously linked to psychological traits. OBJECTIVE: A variable number of tandem repeats within the serotonin transporter-linked polymorphic gene region is believed to alter the transcriptional efficiency of the 5-HTT gene. Therefore, we aimed to investigate the...
Source: Current Drug Metabolism - June 19, 2020 Category: Drugs & Pharmacology Authors: Kandemis E, Tuncel G, Asut O, Temel SG, Ergoren MC Tags: Curr Drug Metab Source Type: research

Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review.
Abstract BACKGROUND: Glycyrrhiza glabra L. (Family: Fabaceae) is one of the important traditional medicinal plant used extensively in folk medicine. INTRODUCTION: It is known for its ethanopharmacological value in curing a wide variety of ailments. Glycyrrhizin, an active compound of G. glabra, possesses anti-inflammatory activity due to which it is mostly used in traditional herbal medicine for the treatment and management of chronic diseases. METHODOLOGY: The present review is focused extensively on the pharmacology, pharmacokinetics, toxicology and potential effects of Glycyrrhizic Acid (GA). A thorou...
Source: Current Drug Metabolism - June 19, 2020 Category: Drugs & Pharmacology Authors: Rehman MU, Farooq A, Ali R, Bashir S, Bashir N, Majeed S, Taifa S, Ahmad SB, Arafah A, Sameer AS, Khan R, Qamar W, Rasool S, Ahmad A Tags: Curr Drug Metab Source Type: research

2020 FDA Drug-Drug Interaction Guidance -Comparison Analysis and Action Plan by Pharmaceutical Industrial Scientists.
CONCLUSION: The new 2020 clinical DDI guidance from the FDA now has even higher harmonization with the guidances (or guidelines) from the EMA and PMDA. A comparison of DDI guidances from the FDA 2017, 2020, EMA, and PMDA on CYP and transporter based DDI, mathematical models, PBPK and clinical evaluation of DDI is presented in this review. PMID: 32562522 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 19, 2020 Category: Drugs & Pharmacology Authors: Sudsakorn S, Bahadduri P, Fretland J, Lu C Tags: Curr Drug Metab Source Type: research

Salidroside - Can it be a multifunctional drug?
CONCLUSION: Salidroside is produced by a three-step pathway in the plants with tyrosol as an intermediate molecule. The molecule is biotransformed into many metabolites through phase I and II pathways. These metabolites, together with a certain amount of salidroside may be responsible for various pharmacological functions. The salidroside based inhibition of PI3k/AKT, JAK/ STAT, and MEK/ERK pathways and activation of apoptosis and autophagy are the major reasons for its anti-cancer activity. AMPK pathway modulation plays a significant role in its anti-diabetic activity. The neuroprotective activity was linked with decrease...
Source: Current Drug Metabolism - June 9, 2020 Category: Drugs & Pharmacology Authors: Magani SKJ, Mupparthi SD, Gollapalli BP, Shukla D, Tiwari AK, Gorantala J, Yarla NS, Tantravahi S Tags: Curr Drug Metab Source Type: research

Review on the clinical pharmacology of hydroxychloroquine sulfate for the treatment of COVID-19.
CONCLUSION: It has been proved that HCQ, which has an established safety profile, is effective against SARS-CoV-2 with sufficient pre-clinical rationale and evidence. Data from high-quality clinical trials are urgently needed worldwide. PMID: 32520683 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 9, 2020 Category: Drugs & Pharmacology Authors: Cui C, Tu S, En VSJ, Li X, Yao X, Li H, Liu D Tags: Curr Drug Metab Source Type: research

Gold nanoparticles; potential nanotheranostic agent in breast cancer: a comprehensive review with systematic search strategy.
CONCLUSION: Divergent strategies have shown the theranostic potential of surface tuned GNPs against breast cancer even in the metastatic stage with minimum cytotoxic effect both in vitro and in vivo. PMID: 32520684 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 9, 2020 Category: Drugs & Pharmacology Authors: Khandker SS, Shakil MS, Hossen MS Tags: Curr Drug Metab Source Type: research

The Potential Role of Serum Exosomes in Preeclampsia.
Abstract Preeclampsia is a serious pregnancy-specific disease that affects about 5%-8% of pregnant women and is the main reason for the increase in maternal and perinatal mortality. Due to unknown etiology, preeclampsia is still the main cause of increased mortality in maternal and perinatal infants, which is mainly manifested by new hypertension after 20 weeks of pregnancy. As the pathogenesis has not been fully elucidated, early diagnosis and full treatment are lacking. Exosomes secreted from the placenta to the peripheral circulation may be involved in the pathogenesis of preeclampsia, and can be detected from ...
Source: Current Drug Metabolism - May 24, 2020 Category: Drugs & Pharmacology Authors: Gao X, Shao L, Ge X, Zhang L, Chen D, He R Tags: Curr Drug Metab Source Type: research