Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems
CONCLUSION: Compared with CYP3A4*1, CYP3A4*18 has a greater metabolism of FK506, clarithromycin and ketoconazole can inhibit both the enzymatic activities of CYP3A4*1 and CYP3A4*18, consequently affecting the metabolism of FK506 and the inhibitory on CYP3A4*1 is stronger.PMID:38523538 | DOI:10.2174/0113892002286019240315052145 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Jinhua Wen Yuwei Xiao Menghua Zhao Chen Yang Weiqiang Hu Source Type: research

The Metabolism of the New Benzodiazepine Remimazolam
CONCLUSION: Besides the pharmacologically non-active metabolite CNS7054, no other clinically significant metabolite of remimazolam could be identified.PMID:38523539 | DOI:10.2174/0113892002301026240318060307 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Wolfgang Schmalix Karl-Uwe Petersen Marija Pesic Thomas St öhr Source Type: research

Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems
CONCLUSION: Compared with CYP3A4*1, CYP3A4*18 has a greater metabolism of FK506, clarithromycin and ketoconazole can inhibit both the enzymatic activities of CYP3A4*1 and CYP3A4*18, consequently affecting the metabolism of FK506 and the inhibitory on CYP3A4*1 is stronger.PMID:38523538 | DOI:10.2174/0113892002286019240315052145 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Jinhua Wen Yuwei Xiao Menghua Zhao Chen Yang Weiqiang Hu Source Type: research

The Metabolism of the New Benzodiazepine Remimazolam
CONCLUSION: Besides the pharmacologically non-active metabolite CNS7054, no other clinically significant metabolite of remimazolam could be identified.PMID:38523539 | DOI:10.2174/0113892002301026240318060307 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Wolfgang Schmalix Karl-Uwe Petersen Marija Pesic Thomas St öhr Source Type: research

Association of UGT1A Gene Polymorphisms with BKV Infection in Renal Transplantation Recipients
Conclusions: We found that genetic variants in the UGT1A gene confer BKV infection susceptibility after kidney transplantation.PMID:38509677 | DOI:10.2174/0113892002282727240307072255 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 21, 2024 Category: Drugs & Pharmacology Authors: Jingwen Yuan Shuang Fei Zeping Gui Zijie Wang Hao Chen Li Sun Jun Tao Zhijian Han Xiaobin Ju Ruoyun Tan Min Gu Zhengkai Huang Source Type: research

Unraveling the Role of COMT Polymorphism in Dopamine-Mediated Vasopressor Effects: An Observational Cross-Sectional Study
CONCLUSION: V158M (rs4680) polymorphism is widely prevalent in the population and was significantly associated with altered effects as observed clinically. This finding suggests valuable insights into the molecular basis of COMT function and its potential impact on neurotransmitter metabolism and related disorders. Large-scale studies delineating the effect of these polymorphisms on various vasopressors are the need of the hour.PMID:38509678 | DOI:10.2174/0113892002293952240315064943 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 21, 2024 Category: Drugs & Pharmacology Authors: Kannan Sridharan Anfal Jassim Ali Mohammed Qader Sheikh Abdul Azeez Pasha Source Type: research

Association of UGT1A Gene Polymorphisms with BKV Infection in Renal Transplantation Recipients
Conclusions: We found that genetic variants in the UGT1A gene confer BKV infection susceptibility after kidney transplantation.PMID:38509677 | DOI:10.2174/0113892002282727240307072255 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 21, 2024 Category: Drugs & Pharmacology Authors: Jingwen Yuan Shuang Fei Zeping Gui Zijie Wang Hao Chen Li Sun Jun Tao Zhijian Han Xiaobin Ju Ruoyun Tan Min Gu Zhengkai Huang Source Type: research

Unraveling the Role of COMT Polymorphism in Dopamine-Mediated Vasopressor Effects: An Observational Cross-Sectional Study
CONCLUSION: V158M (rs4680) polymorphism is widely prevalent in the population and was significantly associated with altered effects as observed clinically. This finding suggests valuable insights into the molecular basis of COMT function and its potential impact on neurotransmitter metabolism and related disorders. Large-scale studies delineating the effect of these polymorphisms on various vasopressors are the need of the hour.PMID:38509678 | DOI:10.2174/0113892002293952240315064943 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 21, 2024 Category: Drugs & Pharmacology Authors: Kannan Sridharan Anfal Jassim Ali Mohammed Qader Sheikh Abdul Azeez Pasha Source Type: research

Association of UGT1A Gene Polymorphisms with BKV Infection in Renal Transplantation Recipients
Conclusions: We found that genetic variants in the UGT1A gene confer BKV infection susceptibility after kidney transplantation.PMID:38509677 | DOI:10.2174/0113892002282727240307072255 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 21, 2024 Category: Drugs & Pharmacology Authors: Jingwen Yuan Shuang Fei Zeping Gui Zijie Wang Hao Chen Li Sun Jun Tao Zhijian Han Xiaobin Ju Ruoyun Tan Min Gu Zhengkai Huang Source Type: research

Unraveling the Role of COMT Polymorphism in Dopamine-Mediated Vasopressor Effects: An Observational Cross-Sectional Study
CONCLUSION: V158M (rs4680) polymorphism is widely prevalent in the population and was significantly associated with altered effects as observed clinically. This finding suggests valuable insights into the molecular basis of COMT function and its potential impact on neurotransmitter metabolism and related disorders. Large-scale studies delineating the effect of these polymorphisms on various vasopressors are the need of the hour.PMID:38509678 | DOI:10.2174/0113892002293952240315064943 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 21, 2024 Category: Drugs & Pharmacology Authors: Kannan Sridharan Anfal Jassim Ali Mohammed Qader Sheikh Abdul Azeez Pasha Source Type: research

Association of UGT1A Gene Polymorphisms with BKV Infection in Renal Transplantation Recipients
Conclusions: We found that genetic variants in the UGT1A gene confer BKV infection susceptibility after kidney transplantation.PMID:38509677 | DOI:10.2174/0113892002282727240307072255 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 21, 2024 Category: Drugs & Pharmacology Authors: Jingwen Yuan Shuang Fei Zeping Gui Zijie Wang Hao Chen Li Sun Jun Tao Zhijian Han Xiaobin Ju Ruoyun Tan Min Gu Zhengkai Huang Source Type: research

Unraveling the Role of COMT Polymorphism in Dopamine-Mediated Vasopressor Effects: An Observational Cross-Sectional Study
CONCLUSION: V158M (rs4680) polymorphism is widely prevalent in the population and was significantly associated with altered effects as observed clinically. This finding suggests valuable insights into the molecular basis of COMT function and its potential impact on neurotransmitter metabolism and related disorders. Large-scale studies delineating the effect of these polymorphisms on various vasopressors are the need of the hour.PMID:38509678 | DOI:10.2174/0113892002293952240315064943 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 21, 2024 Category: Drugs & Pharmacology Authors: Kannan Sridharan Anfal Jassim Ali Mohammed Qader Sheikh Abdul Azeez Pasha Source Type: research

Fluoropyrimidine Toxicity: the Hidden Secrets of DPYD
CONCLUSIONS: DPYD polymorphisms are the main source of DPD variability. A study on DPYD epigenetics (both transcriptionally and post-transcriptionally) holds promise to provide insights into molecular pathways of fluoropyrimidine toxicity. Additional post-translational DPD modifications, as well as DPD inhibition by other drugs, may explain a proportion of enzyme activity variability. Therefore, there is still a lot we can learn about the DPYD/DPD fluoropyrimidine-induced toxicity machinery.PMID:38504562 | DOI:10.2174/0113892002296707240311105527 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 20, 2024 Category: Drugs & Pharmacology Authors: Vangelis G Manolopoulos Georgia Ragia Source Type: research

Fluoropyrimidine Toxicity: the Hidden Secrets of DPYD
CONCLUSIONS: DPYD polymorphisms are the main source of DPD variability. A study on DPYD epigenetics (both transcriptionally and post-transcriptionally) holds promise to provide insights into molecular pathways of fluoropyrimidine toxicity. Additional post-translational DPD modifications, as well as DPD inhibition by other drugs, may explain a proportion of enzyme activity variability. Therefore, there is still a lot we can learn about the DPYD/DPD fluoropyrimidine-induced toxicity machinery.PMID:38504562 | DOI:10.2174/0113892002296707240311105527 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 20, 2024 Category: Drugs & Pharmacology Authors: Vangelis G Manolopoulos Georgia Ragia Source Type: research

Safety Aspects of Herb Interactions: Current Understanding and Future Prospects
CONCLUSION: This article can serve as a lead for clinicians, guiding them regarding herb-drug, herb-food, and herb-herb interactions induced by commonly consumed plant species. Patients may also be counseled to avoid conventional drugs, botanicals, and foods with a restricted therapeutic window.PMID:38482621 | DOI:10.2174/0113892002289753240305062601 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 14, 2024 Category: Drugs & Pharmacology Authors: Subhajit Hazra Preet Amol Singh Source Type: research