Serial quantification of urinary protein biomarkers to predict drug-induced acute kidney injury.
CONCLUSION: Serial surveillance of these biomarkers could improve the lead time for nephrotoxicity detection by days. PMID: 31296157 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 11, 2019 Category: Drugs & Pharmacology Authors: Da Y, Akalya K, Murali T, Vathsala A, Tan CS, Low S, Lim HN, Teo BW, Lau T, Ong L, Chua HR Tags: Curr Drug Metab Source Type: research

A Change in Bile Flow: Looking Beyond Transporter Inhibition in the Development of Drug-induced Cholestasis.
CONCLUSION: Among others, efforts have continued to focus on BSEP, as it is the primary route for hepatic biliary clearance. In addition to inhibition, drug-induced BSEP repression or the combination of these two has emerged as important alternative mechanisms leading to DIC. Furthermore, there has been an evolution in the approaches to studying DIC including 3D cell cultures and computational modeling. PMID: 31288715 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 9, 2019 Category: Drugs & Pharmacology Authors: Garzel B, Zhang L, Huang SM, Wang H Tags: Curr Drug Metab Source Type: research

The Role of the Sodium-taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) in Related Liver Disease.
CONCLUSION: NTCP and BSEP are important proteins for transportation and homeostasis maintenance of bile acids. Further research is needed to develop new models for determining the structure-function relationship of bile acid transporters and screening for substrates and inhibitors, as well as to gain more information about the regulatory genetic mechanisms involved in the processes of liver injury. PMID: 31258056 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 3, 2019 Category: Drugs & Pharmacology Authors: Lu X, Liu L, Shan W, Kong L, Chen N, Lou Y, Zeng S Tags: Curr Drug Metab Source Type: research

Association of genetic variants in CYP3A4, CYP3A5, CYP2C8, and CYP2C19 with tacrolimus pharmacokinetics in renal transplant recipients.
CONCLUSIONS: Two tagger SNPs, namely, rs15524 and rs4646453, are significantly related to the variability of TAC disposition, and TAC measurement time points, BMI, usage of sirolimus, and incidence of DGF contribute to this influence. Recipients carrying H2/H2 (GG-AA) haplotype in rs15524-rs4646453 may require a low dosage of TAC during 1-year follow-up posttransplant. PMID: 31244435 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 26, 2019 Category: Drugs & Pharmacology Authors: Wang Z, Zheng M, Yang H, Han Z, Tao J, Chen H, Sun L, Guo M, Wang L, Tan R, Wei JF, Gu M Tags: Curr Drug Metab Source Type: research

Nanogels for Skin Cancer Therapy via Transdermal Delivery: Current Designs.
CONCLUSION: Advanced techniques for effective skin cancer therapy based on the nanogel's penetration and cellular uptake abilities will be discussed. Techniques for penetrating the skin, as well as drug release, permeation studies, and microscopic observations, will also be discussed. PMID: 31237201 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 17, 2019 Category: Drugs & Pharmacology Authors: Tran PHL, Duan W, Lee BJ, Tran TTD Tags: Curr Drug Metab Source Type: research

Hepatic Artery and Peripheral Vein Pharmacokinetics of Raltitrexed in Swine After the Administration of a Hepatic Arterial Infusion.
CONCLUSION: The pharmacokinetic model could be helpful in quantitatively describing the detailed processes of raltitrexed activity administered by HAI and determining an appropriate dosing regimen for preclinical and clinical studies. PMID: 31237202 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 17, 2019 Category: Drugs & Pharmacology Authors: Zhu L, Zheng N, Li X, Zhang X Tags: Curr Drug Metab Source Type: research

Impact of Drug Metabolism/Pharmacokinetics and their Relevance Upon Traditional Medicine-based Cardiovascular Drug Research.
CONCLUSION: In the context of systems pharmacology, the DMPK knowledge base is expected to translate bench findings to the clinical applications, as well as to foster cardiovascular drug discovery and development. PMID: 31237211 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 17, 2019 Category: Drugs & Pharmacology Authors: Hao DC, Xiao PG Tags: Curr Drug Metab Source Type: research

Nanomedicine: Bioavailability, Biotransformation and Biokinetics.
CONCLUSION: Bioavailability results based on various nanomedicine are summarized in the present work. Biotransformation of nanodrugs, as well as nanoformulations, is also the focus of this article. Both in vitro and in vivo biotransformation studies on nanodrugs and its excipients are necessary to know the effect of metabolites formed. Biokinetics of nanomedicine is captured in details that are complementary to bioavailability and biotransformation. Nanomedicine has the potential to be developed as a personalized medicine once its physicochemical properties and its effect on biological system is well understood. PMID:...
Source: Current Drug Metabolism - June 14, 2019 Category: Drugs & Pharmacology Authors: Ravindran S, Tambe AJ, Suthar JK, Chahar DS, Fernandes JM, Desai V Tags: Curr Drug Metab Source Type: research

The Metabolism and Disposition of Koumine, Gelsemine and Humantenmine from Gelsemium.
CONCLUSION: This review not only explains the pharmacokinetics of indole alkaloids from Gelsemium but also facilitates further study on their metabolism and mechanism of toxicity. PMID: 31203797 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 14, 2019 Category: Drugs & Pharmacology Authors: Wang ZY, Zuo MT, Liu ZY Tags: Curr Drug Metab Source Type: research

Delivery of Local Anesthesia: Current Strategies, Safety, and Future Prospects.
CONCLUSION: The findings of this review article endorse that safe delivery of anesthesia drugs are essential for the safety of patients. Further, nanotechnology-based strategies are extremely useful for targeted delivery of anesthetic drugs at the required dose without affecting the neighboring tissues. PMID: 31187706 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 10, 2019 Category: Drugs & Pharmacology Authors: Liu GL, Bian WC, Zhao P, Sun LH Tags: Curr Drug Metab Source Type: research

The Application of Machine Learning Techniques in Protein Drugs and Drug Targets Recognition.
Abstract PMID: 31154996 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 4, 2019 Category: Drugs & Pharmacology Authors: Ding H Tags: Curr Drug Metab Source Type: research

Interethnic variations of UGT1A1 and UGT1A7 Polymorphisms in the Jordanian Population.
CONCLUSION: This inter-ethnic variation in the UGT1A alleles frequencies may affect drug response and susceptibility to cancers among different subethnic groups in Jordan. Our results can also provide useful information for the Jordanian population and for future genotyping of Circassian and Chechen populations in general. PMID: 31132973 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 27, 2019 Category: Drugs & Pharmacology Authors: Abudahab S, Hakooz N, Jarrar Y, Al Shahhab M, Saleh A, Zihlif M, Dajani R Tags: Curr Drug Metab Source Type: research

Vitamin D in inflammatory bowel disease: Biological, clinical and therapeutic aspects.
CONCLUSION: Well-designed intervention studies are needed in IBD, with probably higher objective plasma doses of vitamin D to establish its efficacy as a therapeutic agent with immunomodulatory properties. Meanwhile, vitamin D deficiency should be screened for and corrected in affected patients in order to achieve adequate bone and phosphocalcic metabolism. PMID: 31109269 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - May 20, 2019 Category: Drugs & Pharmacology Authors: Olmedo-Martín RV, González-Molero I, Olveira G, Amo-Trillo V, Jiménez-Pérez M Tags: Curr Drug Metab Source Type: research

Effects of Radiation on Drug Metabolism: A Review.
CONCLUSION: The findings of this review indicated that radiation caused by environmental pollution or clinical treatments can alter the pharmacokinetic characteristics of drugs. Thus, the pharmacokinetics of drugs should be re-checked and the optimal dose should be re-evaluated after radiation. PMID: 30961479 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 5, 2019 Category: Drugs & Pharmacology Authors: Li X, Yang J, Qiao Y, Duan Y, Xin Y, Nian Y, Zhu L, Liu G Tags: Curr Drug Metab Source Type: research

Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure.
CONCLUSION: The molecular basis for the effect of uremia on non-renal drug elimination still needed to be clarified with further studies to generate generalizable concepts, which may provide insights into establishing better clinical usage of anticancer drugs, i.e. identifying patients at risk and dose adjustment. PMID: 30947665 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 2, 2019 Category: Drugs & Pharmacology Authors: Fujita KI, Matsumoto N, Ishida H, Kubota Y, Iwai S, Shibanuma M, Kato Y Tags: Curr Drug Metab Source Type: research

Letter to the Editor on "A System Pharmacology Study for Deciphering Anti Depression Activity of Nardostachys jatamansi".
Letter to the Editor on "A System Pharmacology Study for Deciphering Anti Depression Activity of Nardostachys jatamansi". Curr Drug Metab. 2019 Apr 02;: Authors: Sadri A Abstract This letter is in reference to a recent article published in Current Drug Metabolism; A System Pharmacology Study for Deciphering Anti Depression Activity of Nardostachys jatamansi. Unfortunately, there is a major error mentioned in the material and method section of the study, which jeopardizes the study's goal. PMID: 30947666 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 2, 2019 Category: Drugs & Pharmacology Authors: Sadri A Tags: Curr Drug Metab Source Type: research

Herb-Drug Interactions and Hepatotoxicity.
CONCLUSION: Herb-drug interaction related morbidity is thus an emerging serious public health issue with broad implications for clinicians, pharmaceutical industries and health authorities. Nonetheless, despite increasing recognition of herb-drug interaction, a standard system for interaction prediction and evaluation is still nonexistent. This review article discusses the herb-drug interactions related hepatotoxicity and underlying mechanisms, including drug metabolizing enzymes and their regulation. PMID: 30914020 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2019 Category: Drugs & Pharmacology Authors: Parvez MK, Rishi V Tags: Curr Drug Metab Source Type: research

Tubular and Glomerular Biomarkers of Acute Kidney Injury in Newborns.
CONCLUSION: In this systematic review of the literature, we have highlighted the usefulness of biomarkers in predicting tubular and/or glomerular injury in newborns. However, novel biomarkers need to prove their clinical applicability, accuracy, and cost effectiveness prior to the implementation into clinical practice. PMID: 30907310 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 21, 2019 Category: Drugs & Pharmacology Authors: Kamianowska M, Szczepański M, Wasilewska A Tags: Curr Drug Metab Source Type: research

Preface.
PMID: 30887914 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 20, 2019 Category: Drugs & Pharmacology Authors: Sinz M Tags: Curr Drug Metab Source Type: research

Crosstalk Between Nutrients and Xenobiotic Receptors.
PMID: 30887915 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 20, 2019 Category: Drugs & Pharmacology Authors: Ma X Tags: Curr Drug Metab Source Type: research

Recent Findings on Nanotechnology-based Therapeutic Strategies against Hepatocellular Carcinoma.
CONCLUSION: In this review, we discussed the key challenges, recent findings and future perspective in the development of effective nanotechnology-based cancer therapeutics. The emphasis here is focused on nanotechnology-based therapies that are likely to affect clinical investigations and their implications for advancing the treatment of patients with hepatocellular carcinoma. PMID: 30854953 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 8, 2019 Category: Drugs & Pharmacology Authors: Samie HAA, Saeed M, Faisal SM, Kamal MA Tags: Curr Drug Metab Source Type: research

PI3K/Akt-Nrf2 and Anti-Inflammation Effect of Macrolides in Chronic Obstructive Pulmonary Disease.
CONCLUSION: This review indicates that PI3K/Ak-Nrf2 may play an important role in COPD inflammation and macrolides may reduce lung and systemic inflammation of COPD by regulating PI3K/Akt-Nrf2 pathway. However, many crucial and essential questions remain to be answered. Further understanding of the mechanisms of macrolide efficacy and PI3K/Akt-Nrf2-mediated inflammatory responses may provide new clue for exploring COPD treatment in the future. PMID: 30827233 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 27, 2019 Category: Drugs & Pharmacology Authors: Sun X, Chen L, He Z Tags: Curr Drug Metab Source Type: research

Genitourinary Tumors: Update on Molecular Biomarkers for Diagnosis, Prognosis and Prediction of Response to Therapy.
CONCLUSION: The identification of effective biomarkers has become a major focus in cancer research, mainly due to the necessity of selecting potentially responsive patients in order to improve their outcomes, as well as to reduce the toxicity and costs related to ineffective treatments. PMID: 30799789 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 25, 2019 Category: Drugs & Pharmacology Authors: Cimadamore A, Scarpelli M, Santoni M, Massari F, Tartari F, Cerqueti R, Lopez-Beltran A, Cheng L, Montironi R Tags: Curr Drug Metab Source Type: research

Investigating the Metabolism of ACT-541468, Utilizing a Microtracer and Accelerator Mass Spectrometry in The First-in-Humans Trial.
In conclusion, ACT-541468 is extensively metabolized predominantly by oxidative transformations. PMID: 30727881 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 6, 2019 Category: Drugs & Pharmacology Authors: Muehlan C, Fischer H, Zimmer D, Aissaoui H, Grimont J, Boss C, Croft M, van Gerven J, Krähenbühl S, Dingemanse J Tags: Curr Drug Metab Source Type: research

Clinical Implications Of Methotrexate Pharmacogenetics In Childhood Acute Lymphoblastic Leukaemia.
Abstract In the past two decades, a great body of research has been published regarding the effects of genetic polymorphisms on methotrexate (MTX)-induced toxicity and efficacy. Of particular interest is the role of this compound in childhood acute lymphoblastic leukaemia (ALL), where it is a pivotal drug in the different treatment protocols, both at low and high doses. MTX acts on a variety of target enzymes in the folates cycle, as well as being transported out and into of the cell by several transmembrane proteins. This review aims to summarize the current knowledge concerning the clinical impact of polymorphis...
Source: Current Drug Metabolism - January 30, 2019 Category: Drugs & Pharmacology Authors: Gervasini G, Mota-Zamorano S Tags: Curr Drug Metab Source Type: research

Recent Advances on Prediction of Human Papillomaviruses Risk Types.
CONCLUSION: From the prediction accuracy, we get that the classification results are more accurate by establishing mathematical models. Thus, adopting mathematical methods to predict risk type of HPV will be the main goal of research in the future. PMID: 30657038 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 17, 2019 Category: Drugs & Pharmacology Authors: Yao Y, Xu H, Li M, Qi Z, Liao B Tags: Curr Drug Metab Source Type: research

Effects of CYP2C8 and SLCO1B1 genetic polymorphisms on repaglinide pharmacokinetics: A systematic review and meta-analysis.
Abstract OBJECTIVE: The purpose of this systematic review and meta-analysis was to summarize the potential impact of CYP2C8 and SLCO1B1 genetic polymorphisms on repaglinide pharmacokinetics. METHOD: A systematic search was conducted using electronic databases. Eligible studies reported data from pharmacokinetic evaluations of repaglinide in healthy adults according to different categories of CYP2C8 and SLCO1B1 genetic polymorphisms. RESULTS: Six studies including a total of 191 participants met the inclusion criteria. We noted that CYP2C8 *1/*3 carriers exhibited lower AUC(0-∞) (SMD: -0.77; 95%CI: ...
Source: Current Drug Metabolism - January 10, 2019 Category: Drugs & Pharmacology Authors: Zhou S, Xiang Q, Mu G, Ma L, Chen S, Xie Q, Zhang Z, Cui Y Tags: Curr Drug Metab Source Type: research

A metabonomics approach to drug toxicology in liver disease and its application in Traditional Chinese Medicine.
CONCLUSION: Metabonomics has great advantages in all aspects of the therapy of liver diseases, with good prospects for clinical application. PMID: 30599107 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - December 31, 2018 Category: Drugs & Pharmacology Authors: Su G, Wang H, Bai J, Chen G, Pei Y Tags: Curr Drug Metab Source Type: research

GHB Pharmacology and Toxicology: From Metabolism and Pharmacokinetics to Applications: In Clinical and Forensic Toxicology.
zzi G Abstract PMID: 30484395 [PubMed - in process] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - December 1, 2018 Category: Drugs & Pharmacology Authors: Busardò FP, Vergallo GM, Plazzi G Tags: Curr Drug Metab Source Type: research

Progress in the Consideration of Possible Sex Differences in Drug Interaction Studies.
CONCLUSION: This review has shown that only limited progress had been made with the inclusion of both sexes in DDI studies. PMID: 30488793 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 28, 2018 Category: Drugs & Pharmacology Authors: Naidoo P, Chetty M Tags: Curr Drug Metab Source Type: research

Nanotherapeutics for the treatment of cancer and arthritis.
Abstract Nanotechnology is gaining significant attention worldwide for the treatment of complex disease such as AIDS (acquired immune deficiency syndrome), cancer and rheumatoid arthritis. Nanomedicine is the application of nanotechnology used for diagnosis and treatment for the disease that includes the preservation and improvement of human health by covering an area such as drug delivery using nanocarriers, nanotheranostics and nanovaccinology. The present article provides an insight on several aspects of nanomedicine such as usages of multiple type of nanocarriers, their status, advantages and disadvantages wit...
Source: Current Drug Metabolism - November 26, 2018 Category: Drugs & Pharmacology Authors: Patel P, Meghani N, Kansara K, Kumar A Tags: Curr Drug Metab Source Type: research

Removal of Pharmaceutical Contaminants in Wastewater using Nanomaterials: A Comprehensive Review.
CONCLUSION: The recommendations provided in this article will be useful to adopt novel strategies for on-site removal of the emerging contaminants in pharmaceutical effluents and related industries. PMID: 30479212 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 26, 2018 Category: Drugs & Pharmacology Authors: Chauhan A, Sillu D, Agnihotri S Tags: Curr Drug Metab Source Type: research

Magnetic Nanoparticles: Current Trends and Future Aspects in Diagnostics and Nanomedicine.
CONCLUSION: MNPs have found widespread use as contrast agents in imaging modalities, as tools for bio-sensing, and as therapeutic and theranostics agents. Multiple formulations of MNPs are in clinical testing and may be accepted in clinical settings in near future. PMID: 30465498 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 22, 2018 Category: Drugs & Pharmacology Authors: Vallabani NVS, Singh S, Karakoti A Tags: Curr Drug Metab Source Type: research

Iron oxide nanoparticles for breast cancer theranostics.
CONCLUSION: This review mainly focuses on the versatile applications of superparamagnetic iron oxide nanoparticles on the diagnosis, treatment, and detecting progress of breast cancer treatment. Their wide application is because of their excellent superparamagnetic, biocompatible and biodegradable properties. PMID: 30465497 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 21, 2018 Category: Drugs & Pharmacology Authors: Shakil S, Hasan A, Sarker SR Tags: Curr Drug Metab Source Type: research

Metabolic Pathway of Cyclosporine A and Its Correlation with Nephrotoxicity.
Abstract Cyclosporine A (CsA) is widely used for organ transplantation and autoimmune disorders. However, CsA nephrotoxicity is a serious side effect that limits the clinical use of CsA. Notably, the metabolism of CsA has a close relationship with this disease in renal-transplant patients. The major metabolic pathways of CsA in humans are hydroxylation (AM1 and AM9) and N-demethylation (AM4N). Normally, these metabolites are relatively less toxic than CsA. However, the metabolism of CsA in the kidneys is much weaker than that in the liver, which explains why CsA is so toxic to the kidneys. CYP3A families, especial...
Source: Current Drug Metabolism - October 31, 2018 Category: Drugs & Pharmacology Authors: Wu Q, Kuca K Tags: Curr Drug Metab Source Type: research

Recent advances in machine learning methods for predicting heat shock proteins.
Abstract As molecular chaperones, heat shock proteins (HSPs) not only play key roles in protein folding and maintaining protein stabilities, but also linked with multiple kinds of diseases. Therefore, HSPs have been regarded as the focus of drug design. Since HSPs from different families play distinct functions, accurately classifying the families of HSPs is the key step to clearly understand their biological functions. In contrast to labor-intensive and cost-ineffective experimental methods, accurately computational classification of HSP families has emerged to be an alternative approach. In this work, we reviewe...
Source: Current Drug Metabolism - October 30, 2018 Category: Drugs & Pharmacology Authors: Chen W, Feng P, Liu T, Jin D Tags: Curr Drug Metab Source Type: research

Nutritional Deficiencies after Gastric Bypass: Mechanisms Involved and Strategies to Improve Oral Supplement Disposition.
CONCLUSION: Oral supplement disposition is altered following RYGB. As a result, patients are required to take complex regimens of oral supplementation indefinitely. The dosage which confers optimum health benefit while avoiding potential toxicity and tolerability issues remains unknown. Novel preparations are needed to optimally address post-RYGB nutritional deficiencies. PMID: 30362417 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - October 26, 2018 Category: Drugs & Pharmacology Authors: Mangan A, Roux CL, Miller NG, Docherty N Tags: Curr Drug Metab Source Type: research

Anti-leishmanial Nanotherapeutics: A Current Perspective.
Abstract Leishmaniasis is a dreaded disease caused by protozoan parasites belonging to the genus Leishmania which results in significant morbidity and mortality worldwide. There are no vaccines available currently for the treatment of Leishmaniasis and chemotherapy still remains the mainstay for anti-leishmanial therapeutics. However, toxicity, reduced bioavailability, high cost and chemoresistance are the principal problems which limit the use of the available drugs. In this context, anti-leishmanial nanotherapeutics may show the way for effective treatment of this dreaded disease. In this review, we discuss the ...
Source: Current Drug Metabolism - October 22, 2018 Category: Drugs & Pharmacology Authors: Shah A, Gupta SS Tags: Curr Drug Metab Source Type: research

Effects of Gut Microbiota on Drug Metabolism and Guidance for Rational Drug Use under Hypoxic Conditions at High Altitudes.
CONCLUSION: This review provides an overview of the effects of gut microbiota on drug metabolism and provides guidance for rational drug use under hypoxic conditions at high altitudes. PMID: 30338735 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - October 19, 2018 Category: Drugs & Pharmacology Authors: Zhang J, Zhang J, Wang R, Jia Z Tags: Curr Drug Metab Source Type: research

Survey of Machine Learning Techniques for Prediction of the Isoform Specificity of Cytochrome P450 Substrates.
CONCLUSION: Both single-label and multi-label classification methods have demonstrated good performance on modelling and prediction of the isoform specificity of substrates based on their quantitative descriptors. PMID: 30338736 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - October 18, 2018 Category: Drugs & Pharmacology Authors: Xiong Y, Qiao Y, Kihara D, Zhang HY, Zhu X, Wei DQ Tags: Curr Drug Metab Source Type: research

Machine Learning in Quantitative Protein-Peptide Affinity Prediction: Implications for Therapeutic Peptide Design.
CONCLUSION: There is still a long way to go before establishment of general, reliable and efficient machine leaning-based protein-peptide affinity predictors. PMID: 30317994 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - October 12, 2018 Category: Drugs & Pharmacology Authors: Li Z, Miao Q, Yan F, Meng Y, Zhou P Tags: Curr Drug Metab Source Type: research

Advances and Application of a Novel Oral Anticoagulant in Specific Populations: Dabigatran Etexilate.
Abstract Dabigatran etexilate (DE) was approved by the FDA in 2010 to reduce the risk of stroke and systemic embolism in adults with non-valvular atrial fibrillation (NVAF). Compared with warfarin, a traditional anticoagulant drug, DE exhibits a shorter half-life, improved dose-effect relationship, fewer food and drug interactions, and can be taken orally without monitoring the conventional coagulation index. DE can also prevent or reduce the severity of adverse events, such as attenuated drug efficacy or bleeding. It is convenient for patients to take DE due to low levels of individual variation. We review the ph...
Source: Current Drug Metabolism - October 11, 2018 Category: Drugs & Pharmacology Authors: Xu D, Su C, Pan J Tags: Curr Drug Metab Source Type: research

The Development of Machine Learning Methods in Cell-Penetrating Peptides Identification: A Brief Review.
CONCLUSION: In this review, the last studies on CPP identification using machine learning method were reported. We also discussed the future development direction of CPP recognition with computational methods. PMID: 30317992 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - October 10, 2018 Category: Drugs & Pharmacology Authors: Wei HH, Yang W, Tang H, Lin H Tags: Curr Drug Metab Source Type: research

Drug-drug interactions of P-gp substrates unrelated to CYP metabolism.
Abstract In this decade, it is known that the role of several drug transporters is to act as a key player in drug disposition, and then they can affect clinical significances. Nevertheless, most of the drug-drug interaction (DDI) studies have been related to cytochrome P450s (CYPs), and these are followed by in vitro and in vivo drug-interactive reports on drug-transporters, which are accumulating. In addition, when both substrate drugs of CYPs and drug transporters (e.g., P-glycoprotein, P-gp) are related to DDIs, it remains that the mechanisms of DDIs will be quite ambiguous in assessing how much the CYPs and/or...
Source: Current Drug Metabolism - October 3, 2018 Category: Drugs & Pharmacology Authors: Akamine Y, Yasui-Furukori N, Uno T Tags: Curr Drug Metab Source Type: research

Survey of Drug Oxidation Activities in Liver and Intestine Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model.
CONCLUSION: The marmoset could be a model animal for humans with respect to the first-pass extraction of terfenadine and related substrates. These findings provide a foundation for understanding individual pharmacokinetic and toxicological results in nonhuman primates as preclinical models and will help to further support understanding of the molecular mechanisms of human P450 function. PMID: 30280664 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - October 3, 2018 Category: Drugs & Pharmacology Authors: Uehara S, Oshio T, Nakanishi K, Tomioka E, Suzuki M, Inoue T, Uno Y, Sasaki E, Yamazaki H Tags: Curr Drug Metab Source Type: research

A Review of Recent Advances and Research on Drug Target Identification Methods.
Abstract From a therapeutic viewpoint, understanding how drugs bind and regulate the functions of their target proteins to protect against disease is crucial. The identification of drug targets plays a significant role in drug discovery and in studying the mechanisms of diseases. The development of methods to identify drug targets has become a popular issue in this field of research. Originally, scientists used biological experiments to identify drug targets. However, recently, an increasing number of scientists use computational methods to identify drug targets. Although thousands of drug targets are estimated to...
Source: Current Drug Metabolism - September 24, 2018 Category: Drugs & Pharmacology Authors: Hu Y, Zhao T, Zhang N, Zhang Y, Cheng L Tags: Curr Drug Metab Source Type: research

A Review of Theranostics Applications and Toxicities of Carbon Nanomaterials.
CONCLUSION: In brief, this review article discusses the numerous theranostics applications and toxicities of CNMs. Biomolecules-functionalized oxygenated GO and CNTs are more efficacious than the other CNMs with abridged cellular toxicity. PMID: 30251600 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - September 24, 2018 Category: Drugs & Pharmacology Authors: Gupta N, Rai DB, Jangid AK, Kulhari H Tags: Curr Drug Metab Source Type: research

Influence of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics/Pharmacodynamics of Tacrolimus in pediatric patients.
Abstract Single nucleotide polymorphisms (SNPs) are the most common variants in many genes, which are also promising markers in relation to drug responses in pharmacogenomics studies. Tacrolimus is a primary immunosuppressant used for the prevention of organ rejection in pediatric organ transplantation. Tacrolimus, transported out of cells via P-glycoprotein (ABCB1), is also a metabolic substrate for cytochrome P450 (CYP) 3A enzymes, especially the CYP3A4 and the CYP3A5. The SNP of these genes have been studied extensively in adult population, but there is no systematic review in children. In this paper, we focus ...
Source: Current Drug Metabolism - September 24, 2018 Category: Drugs & Pharmacology Authors: Yang M, Wang M, Gui H, Mao C Tags: Curr Drug Metab Source Type: research

Replacing GHB with GBL in recreational settings: a new trend in chemsex.
CONCLUSIONS: GBL currently represents a growing public health issue since the substance relatively cheaper and easier to obtain than GHB. Improvement and implementation of laws and policies to place GBL under control are needed to limit its diffusion, the eventual health threat for users and its non -negligible abuse liability and dependence risk. PMID: 30251602 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - September 24, 2018 Category: Drugs & Pharmacology Authors: Busardo FP, Gottardi M, Tini A, Minutillo A, Marinelli E, Zaami S Tags: Curr Drug Metab Source Type: research

Cancer Nanotechnology: A New Revolution for Cancer Diagnosis and Therapy.
Conclusion- This review highlights various approaches of cancer nanotechnology in the advancement of cancer therapy. PMID: 30227814 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - September 18, 2018 Category: Drugs & Pharmacology Authors: Chaturvedi VK, Singh A, Singh VK, Singh MP Tags: Curr Drug Metab Source Type: research