Irpexlacte A-D, four new bioactive metabolites of endophytic fungus Irpex lacteus DR10-1 from the waterlogging tolerant plant Distylium chinense
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Xiao-Xiang Duan, Dan Qin, Hong-Chuan Song, Tian-Cong Gao, Shi-Hao Zuo, Xiao Yan, Jun-Qi Wang, Xiao Ding, Ying-Tong Di, Jin-Yan DongAbstractOne new tremulane sesquiterpene, irpexlacte A (1), and three new furan derivatives, irpexlacte B–D (2-4), were isolated from the endophytic fungus Irpex lacteus DR10-1 waterlogging tolerant plant Distylium chinense, together with two known ones, irlactin E (5) and 3β-hydroxycinnamolide (6). Structures of these metabolites were characterized by HRESIMS and NMR spectroscopic methods. The antibacter...
Source: Phytochemistry Letters - June 15, 2019 Category: Chemistry Source Type: research

Structure, absolute configuration and biological evaluation of polyoxygenated meroterpenoids from the marine algal-derived Aspergillus terreus EN-539
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Hong-Lei Li, Xiao-Ming Li, Xin Li, Sui-Qun Yang, Bin-Gui WangAbstractTwo new meroterpenoids, aperterpenes N (1) and O (2), along with two known structurally related derivatives, terretonins A (3) and G (4), were isolated and identified from the marine algal-derived endophytic fungus Aspergillus terreus EN-539. Their structures and absolute configurations were determined by a detailed interpretation of spectroscopic data and by X-ray crystallographic analysis. This is the first establishment of the absolute configurations for terretonins A (3) ...
Source: Phytochemistry Letters - June 7, 2019 Category: Chemistry Source Type: research

The effects of mutation and temperature variation on monacolin K production by monascus sp. and relative statistical parameter analysis of monacolin K production
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Chung-Fu Huang, Shu-Min Shen, Wei-Ting Chen, Chih-Chun ChenAbstractMonacolin K is a secondary metabolite of the Monascus species that restrains cholesterol synthesis. Temperature control is an effective method of improving the rate of monacolin K synthesis. Ultraviolet (UV) irradiation and ethylmethane sulfonate (EMS) were employed to mutate the Monascus strain so that it could be studied. After mutation by UV and EMS, the best monacolin K production strain was scanned after the 2 -h UV irradiation treatment. Monascus U-2 is defined as ...
Source: Phytochemistry Letters - June 7, 2019 Category: Chemistry Source Type: research

New natural coumarins from Trichocline macrocephala (Asteraceae)
This study reports the isolation and elucidation of two undescribed compounds, named 7-methoxy-glaupalol and 8-hydroxy-isogerberacoumarin, along with glaupalol, 5-methoxycoumarin, 5,6-dimethoxycoumarin and 7-methoxycoumarin. Their structures were determined by application of 1D and 2D NMR techniques and HRESIMS analysis. The 5-methylcoumarin glaupalol exhibited antichemotactic activity on leukocytes migration at concentrations from 0.01 to 5 μg/mL.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - June 5, 2019 Category: Chemistry Source Type: research

Three new 2-(2-phenylethyl)chromone derivatives from agarwood of Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae) in Laos
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Yang-Mei Zhao, Li Yang, Wen-Hua Dong, Wei Li, Hui-Qin Chen, Hao Wang, Cai-Hong Cai, Cui-Juan Gai, Wen-Li Mei, Hao-Fu DaiAbstractIn our ongoing effort to study the metabolites from agarwood of Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae) produced in Laos, three new 2-(2-phenylethyl)chromone derivatives (1−3) were isolated. Their structures were elucidated by comprehensive spectroscopic analyses, predominantly by 1D and 2D NMR spectroscopic methods, and by comparison with the reported data. Compound 2 exhibited tyrosinase inhibitory...
Source: Phytochemistry Letters - June 5, 2019 Category: Chemistry Source Type: research

Three new resveratrol trimer Di-C-glucosides in Shorea uliginosa
In this study, the acetone-soluble parts of the stem bark of Shorea uliginosa were analyzed and three new resveratrol trimers, that is, uliginosides E–G (1–3), were isolated. The structures of these isolates were established on the basis of spectroscopic analyses, including detailed NMR and CD spectroscopy. Trimers 1–3 are rare di-C-glucosylated derivatives with two RS-4-C-β-glucopyranoside building blocks.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - June 5, 2019 Category: Chemistry Source Type: research

Inside Front Cover (Editorial Board)
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - May 31, 2019 Category: Chemistry Source Type: research

Contents (graphical abstracts and research highlights)
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - May 31, 2019 Category: Chemistry Source Type: research

Announcements of the Phytochemical Society of Europe
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - May 31, 2019 Category: Chemistry Source Type: research

Cadinane-type sesquiterpenoids and an indolizine alkaloid from the rice fermentation of the fungus Rigidoporus microporus
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Qian Li, He-Ping Chen, Rong Huang, Hui-Xiang Yang, Rui Ma, Yue-Ling Peng, Zheng-Hui Li, Tao Feng, Ji-Kai LiuAbstractTwo previously undescribed cadinane-type sesquiterpenoids, rigidoporones A and B (1 and 2), along with an undescribed racemic indolizine alkaloid, (±)-rigidoporine A (3), were isolated from the rice fermentation of the wood-decay fungus Rigidoporus microporus. The structures of the compounds were established by extensive spectroscopic methods, including 1D & 2D NMR and HRMS spectroscopic analysis. Compounds 1 and 3 wer...
Source: Phytochemistry Letters - May 31, 2019 Category: Chemistry Source Type: research

A lignan and a lignan derivative from the fruit of Forsythia suspensa
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Chang Li, Qian Wei, Zhi-Hao Zou, Chen-Zhi Sun, Qin Wang, Gang Zhao, Xin-Jia Yan, Tian-Yi Yu, Chun-Li GanAbstractThe chemical investigation of a 95% ethanol extract of the fruit of Forsythia suspensa resulted in the isolation of one new lignan and one new lignan derivative, forsythialan E-F, along with two known lignans. Their structures were established based on extensive spectroscopic data analyses, including UV, IR, HRESIMS, 1D NMR and 2D NMR. Absolute configurations of 1-2 were determined by the CD method. In addition, compounds 1-2 were ev...
Source: Phytochemistry Letters - May 30, 2019 Category: Chemistry Source Type: research

Investigation of the antifungal activity of Pterocarpus erinaceus led to the identification of two new diarylpropanoids from its roots
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Nassifatou Koko Tittikpina, Louis P. Sandjo, Frédéric Nana, Véronique Vaillant, Stéphane Fontanay, Stéphanie Philippot, Yerim M. Diop, Komlan Batawila, Koffi Akpagana, Gilbert Kirsch, Raphaël Emmanuel Duval, Claus Jacob, Patrick ChaimbaultAbstractThe popular use of Pterocarpus erinaceus as antimicrobial prompted us to study the antifungal properties of its bark, leaves and roots against Candida albicans, Aspergillus fumigatus, and Aspergillus niger. Thus, the broth microdilution method was used to perfor...
Source: Phytochemistry Letters - May 27, 2019 Category: Chemistry Source Type: research

Glycosidic compounds from Cassia obtusifolia seeds and their inhibitory effects on OATs, OCTs and OATPs
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Shuangyan Wang, Keyu Feng, Lifeng Han, Xin Fang, Youcai Zhang, Heshui Yu, Xu PangAbstractPhytochemical work on water-soluble ingredients extracted from Cassia obtusifolia seeds led to the isolation of twelve glycosidic compounds including three chromone C-glycosides (1-3), two anthraquinone glycosides (4, 5), six naphthopyran glycosides (6-11), and one naphthalene glycoside (12). The structures of all compounds were identified mainly by spectroscopic data analysis; 1-3 were three new chromone C-glycosides, and 4 was a new anthraquinone glycosi...
Source: Phytochemistry Letters - May 27, 2019 Category: Chemistry Source Type: research

Two new diarylheptanoids from the green husks of Juglans regia L. and their cytotoxic activities
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Yue-Xian Jin, Xiao-Ling Ma, Hong-Yan Wei, Xiong-Fei Guo, Guo-Xu Ma, Lei-Ling Shi, Jing ZhangAbstractTwo new diarylheptanoids, 3- hydroxy- 3′,4″- epoxy- 1- (4′- methoxyphenyl) - 7- (3″- hydroxylphenyl)– heptane (1) and 2,3- dihydroxy- 1- (4′- hydroxy- 3′- methoxyphenyl)- 7- (4″- hydroxyphenyl)– heptanes (2), along with two known compounds, JuglaninB (3) and 4,17- dimethoxy- 2- oxatricyclo [13.2.2.13,7] eicosa- 3,5,7 (20),15,17,18- hexaene- 10,16- diol (4), were isolated from the green husks ...
Source: Phytochemistry Letters - May 25, 2019 Category: Chemistry Source Type: research

Cycloschimperols A and B, new cytotoxic cycloartane triterpenoids from Euphorbia schimperi
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Mohamed F.S. Banjar, Gamal A. Mohamed, Ibrahim A. Shehata, Hossam M. Abdallah, Ali A. Shati, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Abdulrahman E. Koshak, Sabrin R.M. IbrahimAbstractTwo new cycloartane-type triterpenoids, cycloschimperols A [cycloart-20,24-dien-3β-ol] (3) and B [26,27-dinor-3β-hydroxy cycloartan-25-al] (4) and two known compounds, 24-methylenecycloartane (1) and cycloart-25-en-3-one (2) were separated from the aerial parts of Euphorbia schimperi C. Presl (Euphorbiaceae). The structural characterization of the...
Source: Phytochemistry Letters - May 22, 2019 Category: Chemistry Source Type: research

New olean-15-ene type gymnemic acids from Gymnema sylvestre (Retz.) R.Br. and their antihyperglycemic activity through α-glucosidase inhibition
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Naila Hassan Ali Alkefai, Saima Amin, Manju Sharma, Javed Ahamad, Showkat R. MirAbstractA mixture of gymnemic acids was precipitated from the water extract of leaves of Gymnema sylvestre (Retz.) R.Br. ex Sm. (Asclepiadaceae) by acidification with 2 N H2SO4. The chromatographic separation of the mixture afforded five new gymnemic acids (1-5). The compounds were characterized as Δ15 oleanane glycosides on the basis of extensive spectral data analysis. The compounds (1-5) showed dose dependent inhibition of α-glucosidase, which...
Source: Phytochemistry Letters - May 22, 2019 Category: Chemistry Source Type: research

Three new ursane-type triterpenoids from the roots of Sanguisorba officinalis L. and their cytotoxic activity
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Rongshen Wang, Mei Jin, Chunshi Jin, Jinfeng Sun, Chao Ye, Tieqiang Zong, Guoqing Chen, Wei Zhou, Gao LiAbstractThree new ursane-type triterpenoids, 3-oxo-15α,19α-dihydroxyurs-12-en-28-oic acid (1), 3-oxo-7β,19α-dihydroxyurs-12-en-28-oic acid (2), and 18,19-seco,1β-hydroxyl-3,19-dioxo-urs-11,13(18)-dien-28-oic acid (3), together with eleven known triterpenoids (4 – 14) were isolated from the roots of Sanguisorba officinalis L. Their structures were characterized from spectroscopic data (1D, 2D NMR and HR-ESI-M...
Source: Phytochemistry Letters - May 22, 2019 Category: Chemistry Source Type: research

Acylsugar diversity in the resin glycosides from Ipomoea tricolor seeds as chemosensitizers in breast cancer cells
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Jhon Castañeda-Gómez, Pedro Lavias-Hernández, Mabel Fragoso-Serrano, Argelia Lorence, Rogelio Pereda-MirandaAbstractMexican morning glory, Ipomoea tricolor Cav., is native to America and widely cultivated as an ornamental plant. High performance liquid chromatography profiling coupled with off-line electrospray mass spectrometry detection was applied to identify novel acylsugar from the CHCl3-soluble resin glycoside from seeds. Dereplication of known tricolorins A-J included the recording of mass values for ions [M ...
Source: Phytochemistry Letters - May 18, 2019 Category: Chemistry Source Type: research

Three new constituents from the fungus of Monascus purpureus and their anti-inflammatory activity
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Ho-Cheng Wu, Ming-Jen Cheng, Ming-Der Wu, Jih-Jung Chen, Yen-Lin Chen, Hsun-Shuo ChangAbstractA chemical study on the EtOAc-soluble fraction of the 95% EtOH extract of red yeast rice fermented with the fungus Monascus purpureus BCRC 38110 (Eurotiaceae) has resulted in the isolation of three new compounds, i.e., two new 5′,6′-dihydrospiro[isochromane-1,2′-pyran]-4′(3′H)-one derivatives, designated as monascuspirolide A (1) and monascuspirolide B (2) and one benzenoid derivative, monapurpureusin B (3), together with t...
Source: Phytochemistry Letters - May 16, 2019 Category: Chemistry Source Type: research

Flavonoids from the seeds of Oroxylum indicum and their anti-inflammatory and cytotoxic activities
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Bing-Lan Wu, Zhou-Wei Wu, Fan Yang, Xiao-Fei Shen, Lun Wang, Bin Chen, Fu Li, Ming-Kui WangAbstractTwo new flavonoid glycosides, named oroxin C (1) and oroxin D (scutellarein 4'-methyl ether 7-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside, 2), together with eight known flavonoids (3–10), were isolated from the seeds of Oroxylum indicum. Their structures were elucidated unambiguously by spectroscopic techniques and chemical methods. Anti-inflammatory and cytotoxic activities of all the isolated compounds were evaluated. Ch...
Source: Phytochemistry Letters - May 16, 2019 Category: Chemistry Source Type: research

New secondary metabolites from the mangrove endophytic fungus Aspergillus versicolor
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Marwa Elsbaey, Chiaki Tanaka, Tomofumi MiyamotoAbstractTwo new oxoindolo diterpene epimers, anthcolorin G 1 and anthcolorin H 2, nine new meroterpenes, (7R,8R)-8-hydroxysydowic acid 4, (7S,10S)-10-hydroxy-sydowic acid 5, (7S,11R)-12-hydroxy-sydowic acid 6, (7S,11R)-12-acetoxy-sydowic acid 7, (7R,8R)-1,8-epoxy-11-hydroxy-sydonic acid 9, 7-deoxy-7,14-didehydro-11-hydroxy-sydonic acid 11, 7-deoxy-7,14-didehydro-12-acetoxy-sydonic acid 14, and (E)-7-deoxy-7,8-didehydro-12-acetoxy-sydonic acid 15, (7R)-11-hydroxy-sydonic acid methyl ester 18, and a...
Source: Phytochemistry Letters - May 16, 2019 Category: Chemistry Source Type: research

Acacetin—A simple flavone exhibiting diverse pharmacological activities
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Ruchi Badoni Semwal, Deepak Kumar Semwal, Sandra Combrinck, Jeanne Trill, Simon Gibbons, Alvaro ViljoenAbstractAcacetin (5,7-dihydroxy-4-methoxyflavone) is a naturally occurring flavonoid, known to possess numerous pharmacological properties, including neuroprotective, cardioprotective, anticancer, anti-inflammatory, antidiabetic, and antimicrobial activities. The molecule is widespread throughout the Plant Kingdom, but is particularly abundant in the Asteraceae, Euphorbiaceae, Passifloraceae, Lamiaceae and Malvaceae families. It has been show...
Source: Phytochemistry Letters - May 13, 2019 Category: Chemistry Source Type: research

Two new cytochalasans from the marine sediment-derived fungus Westerdykella dispersa and their antibacterial activities
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Dan Xu, Xia Zhang, Xiong Shi, Peng-Jie Xian, Liu Hong, Yan-Duo Tao, Xiao-Long YangAbstractTwo new cytochalasans, 16α-methylaspochalasin J (1) and 16-hydroxymethylaspergillin PZ (2), have been characterized from the solid fermentation culture of Westerdykella dispersa isolated from the marine sediments. The structures and relative configurations of 1-2 were elucidated by a combination of spectroscopic methods, as well as by comparison with related known compounds. Compounds 1 and 2 showed moderate antibacterial activity with MIC values ra...
Source: Phytochemistry Letters - May 13, 2019 Category: Chemistry Source Type: research

New friedelane triterpenes from Anchietea pyrifolia
We report the identification of three new friedelane-type triterpenes (1, 2a, 2b) and a new 30-norfriedelane triterpene (3) together with nine known compounds (4-12) that were isolated from the liana stems of A. pyrifolia. The structures of these compounds were elucidated by spectroscopic methods, including HRMS, and 1D/2D-NMR. In vitro cytotoxicity was assessed against two human cancer cell lines, HeLa and HL-60. The new triterpenes 1-3 and known compounds 9, 11, and 12 exhibited moderate activity with IC50 values ranging from 5.7 to 45.0 μM.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - May 11, 2019 Category: Chemistry Source Type: research

Three new triterpenoids transformed from ursolic acid by Mucor spinosus AS3.3450 and their cytotoxicity
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Shan-Shan Zhang, Ling-Shuang He, Yan-Min Zhao, Shan Fu, Dai-Lin Liu, Zi-He Yu, Bai-Chuan LiuAbstractMicrobial transformation of ursolic acid by Mucor spinosus AS 3.3450 was carried out in this paper. Three new compounds (1-3) were isolated and their structures were identified as 3β, 7β-dihydroxy-ursolic acid-28-ethanone (1), 3β, 7β, 21β-trihydroxy-ursolic acid (2), and 3β, 21β-dihydroxy-ursolic acid-3-O-β-D-glucopyranoside (3) based on extensive spectral analysis including HRESI-MS, 1H-NMR, 13C-NMR, HMQC...
Source: Phytochemistry Letters - May 11, 2019 Category: Chemistry Source Type: research

Harziane and cadinane terpenoids from the alga-endophytic fungus Trichoderma asperellum A-YMD-9-2
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Yin-Ping Song, Feng-Ping Miao, Xiao-Rui Liang, Xiu-Li Yin, Nai-Yun JiAbstractIn addition to the known harziandione (1), one new diterpenoid, 3S-hydroxyharzianone (2), and two new sesquiterpenoids, 4-cadinen-11,12-diol (3) and 4-cadinen-11,13-diol (4), were isolated from the culture of Trichoderma asperellum A-YMD-9-2, an endophytic fungal strain from the marine red alga Gracilaria verrucosa. The structures and relative configurations of new isolates were established by analysis of spectroscopic techniques, including 1D/2D NMR, IR, and MS, and ...
Source: Phytochemistry Letters - May 11, 2019 Category: Chemistry Source Type: research

Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Nguyen Thi Hong Van, Tran Thi Tuyen, Pham Minh Quan, Pham Quoc Long, Nguyen Xuan Nhiem, Bui Huu Tai, Cam Thi Inh, Vu Dinh Hoang, Phan Van Kiem, Chau Van Minh, SeonJu Park, Seung Hyun KimAbstractFour new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were e...
Source: Phytochemistry Letters - May 11, 2019 Category: Chemistry Source Type: research

En route to anti-glioblastoma active pomolic acid
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Oliver Kraft, Jana Wiemann, Ahmed Al-Harrasi, René CsukAbstractTormentic acid (3) can be easily photo-reduced by Saito’s procedure and is an ideal starting material for the straightforward synthesis of pomolic acid (1).Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - May 5, 2019 Category: Chemistry Source Type: research

Furanoeremophilanes from Euryops arabicus alleviate metabolic syndrome-associated exaggerated vasoconstriction via direct vasodilatation
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Hossam M. Abdallah, Ali M. El-Halawany, Hany M. El-BassossyGraphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - May 4, 2019 Category: Chemistry Source Type: research

Five new diterpenoids from the barks of Cinnamomum cassia (L.) J. Presl
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Van Cong Pham, Thi Thuy An Nguyen, Thi Oanh Vu, Thao Quyen Cao, Byung Sun Min, Jeong Ah KimAbstractHere, we report the isolation of five new diterpenoids including four lactone-type diterpenes (3, 5-7) and a hemiketal-type diterpene (12) in addition to 10 known compounds from the bark of Cinnamomum cassia (L.) J. Presl. Molecular structures were elucidated by various spectroscopic methods including 1- and 2-dimensional NMR, high-resolution MS, and circular dichroism. No cytotoxic activity was observed for any of the isolated compounds (1-15) a...
Source: Phytochemistry Letters - May 4, 2019 Category: Chemistry Source Type: research

One new sesquiterpene and one new iridoid derivative from Valeriana amurensis
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Yang-Guo Xie, Xin-Cai Zhao, Syed Shams ul Hassan, Xiao-Yong Zhen, Ishaq Muhammad, Shi-kai Yan, Xing Yuan, Hui-liang Li, Hui-zi JinAbstractOne new sesquiterpene 1S, 3S, 4S, 7S 3,4-dihydroxy-bisabolol (1), one new iridoid amurensin A (2) and 10 known compounds were isolated from the whole plants of Valeriana amurensis. Their structures were established on the basis of extensive spectroscopic analysis and the absolute stereochemistry of compound 1 was assigned by X-ray diffraction analysis with Cu-Kα irradiation. All of compounds were evalu...
Source: Phytochemistry Letters - May 4, 2019 Category: Chemistry Source Type: research

New lactone and isocoumarin derivatives from the marine mangrove-derived endophytic fungus Penicillium coffeae MA-314
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Jin Cao, Xiao-Ming Li, Xin Li, Hong-Lei Li, Ling-Hong Meng, Bin-Gui WangAbstractA new δ-lactone (penicoffeazine A, 1) and two pairs of new isocoumarin derivatives (penicoffrazins B and C, 2 and 3), along with five known isocoumarin derivatives (4−8), were isolated from Penicillium coffeae MA-314, an endophytic fungus obtained from the fresh inner tissue of the leaf of marine mangrove plant Laguncularia racemosa. The structures of all these compounds were elucidated by spectroscopic analysis and the absolute configuration of compoun...
Source: Phytochemistry Letters - May 4, 2019 Category: Chemistry Source Type: research

New isoindolinones from the fruiting bodies of the fungus Hericium erinaceus
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Ahmed Ashour, Yhiya Amen, Ahmed E. Allam, Takashi Kudo, Maki Nagata, Koichiro Ohnuki, Kuniyoshi ShimizuAbstractTwo new isoindolin-1-ones, named erinacerin (M–N) along with eleven known compounds have been isolated from the fruiting bodies of the medicinal mushroom Hericium erinaceus. The structures of compounds were elucidated based on spectroscopic studies and comparison with the known related ones. The anticancer potential of the isolates were tested with an in vitro cytotoxic assay against six human cancer cell lines (SH-SY5Y, 1321N1,...
Source: Phytochemistry Letters - May 4, 2019 Category: Chemistry Source Type: research

Neo-clerodane diterpenoids from Teucrium polium subsp. vincentinum (rouy) D. Wood
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Petko I. Bozov, Plamen N. PenchevAbstractFour neo-clerodane diterpenoids, the new polivincins A – C and the known teulamifin B, were isolated by the phytochemical investigation of the acetone extract prepared from the aerial parts of Teucrium polium subsp. vincentinum, (Lamiaceae). The structure and stereochemistry of the compounds were established by IR, HRMS and different (Al-Khalil, 1995) NMR and 2D-NMR techniques.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - April 29, 2019 Category: Chemistry Source Type: research

Facile synthesis of anhydrojudaicin and 11,13-dehydroanhydrojudaicin, two eudesmanolide-skeleton lactones with potential allelopathic activity
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Jesús G. Zorrilla, Carlos Rial, Rosa M. Varela, José M.G. Molinillo, Francisco A. MacíasAbstractNatural product anhydrojudaicin (7) is a eudesmanolide that has been synthesized from costunolide (1) in three steps with good yield, simplifying procedures available in the literature. The key step was the efficient oxidation and rearrangement using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). Following the same methodology, 11,13-dehydroanhydrojudaicin (8) was prepared for the first time. All compounds were characterized and...
Source: Phytochemistry Letters - April 23, 2019 Category: Chemistry Source Type: research

Toonamicronoids A–D, four new B-seco-limonoids from Toona microcarpa
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Ling Zhang, Jianjun Xia, Jianyun Yang, Long Zhu, Danyu Tang, Ji Ma, Yingliang Zhao, Xiaoying Zeng, Minghua QiuAbstractFour new B-seco-limonoids, toonamicronoids A–D (1–4), together with four known ones, toonaciliatin H–J (5–7), and toonacilianin A (8), were isolated from Toona microcarpa. Their structures were identified on the basis of ESIMS, HREIMS and 1D/2D NMR analysis. Compounds 1 and 4 showed moderate cytotoxicities against HL-60 with the IC50values of 17.3 ± 1.5 and 22.7 ± 1.9 μM, respectively.Grap...
Source: Phytochemistry Letters - April 19, 2019 Category: Chemistry Source Type: research

Analysis of phenolic compounds and antioxidant activity of methanolic extracts from inflorescences of Carduus sp
Publication date: Available online 17 April 2019Source: Phytochemistry LettersAuthor(s): Małgorzata Kozyra, Łukasz Komsta, Krzysztof WojtanowskiAbstractIn the present study, the phenolic compounds in 70% (v/v) methanol extracts from the inflorescences of Carduus carlinoides Gouan, Carduus nigrescens Vill, Carduus defloratus L., Carduus nutans L., and Carduus crispus Gouan were identified. The extracts were tested by the RP-HPLC and HPLC/ESI-QTOF/MS methods. Flavonoids and phenolic acids were extracted from the inflorescences by ASE. HPLC profiles (fingerprints) of methanolic Carduus sp. extract were correlated with flavo...
Source: Phytochemistry Letters - April 17, 2019 Category: Chemistry Source Type: research

Morus alba leaf extract: Metabolite profiling and interactions with antibiotics against Staphylococcus spp. including MRSA
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Petruta Aelenei, Simon Vlad Luca, Cristina Elena Horhogea, Cristina Mihaela Rimbu, Gabriel Dimitriu, Irina Macovei, Mihaela Silion, Ana Clara Aprotosoaie, Anca MironAbstractHPLC-DAD-ESI-Q-TOF-MS/MS metabolite profiling of Morus alba leaf extract led to the annotation of 25 constituents (two stilbene derivatives, 11 prenylflavonoids, five 2-arylbenzofurans, seven Diels–Alder type adducts). The extract was found to contain 57.83 mg/g flavonoids, 15.42 mg/g kuwanon G and 10.47 mg/g morusin. Despite its moderate antibacterial activity wi...
Source: Phytochemistry Letters - April 17, 2019 Category: Chemistry Source Type: research

Glucosinolates profiles in Maca phenotypes cultivated in Peru and China (Lepidium peruvianum syn. L. meyenii)
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Henry O. Meissner, Lijia Xu, Wenting Wan, Fan YiAbstractHPLC glucosinolate (GCSN) profiles and concentration levels were examined in hypocotyls of the four prime Maca phenotypes (Lepidium peruvianum synonym L. meyenii) labelled as “Yellow”, “Black”, “Red” and “Purple”, grown in Peru (Pe) and/or China (Cn). In Trial I, glucotropaeolin (GLCT) and m-methoxyglucotropaeolin (MGLCT) content, and their ratios, was determined in commercial Maca products of Pe origin and compared with similar products decla...
Source: Phytochemistry Letters - April 16, 2019 Category: Chemistry Source Type: research

Medicinal plants and bioactive natural compounds for cancer treatment: Important advances for drug discovery
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Fernanda Majolo, Luciana Knabben de Oliveira Becker Delwing, Diorge Jônatas Marmitt, Ivan Cunha Bustamante-Filho, Márcia Inês GoettertAbstractCancer is one of the largest causes of morbimortality in the world and due to its prevalence the discovery of novel anticancer drugs in of great importance. The past century brought great advances in the field of plant and microbiology research, with the development of several compounds used in cancer treatment protocols. Many successful anticancer drugs that are in clinical use and have...
Source: Phytochemistry Letters - April 13, 2019 Category: Chemistry Source Type: research

Cytotoxic chalcones and isoflavones from the stems of Dalbergia velutina
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Sutin Kaennakam, Edwin Risky Sukandar, Kitiya Rassamee, Pongpun Siripong, Santi Tip-pyangAbstractFour new compounds, including two new chalcones, veluchalcone A and B (1 and 2), and two new isoflavones, veluisoflavone A and B (3 and 4), together with five known chalcones (5–9) and ten known isoflavones (10–19), were isolated from the stems of Dalbergia velutina. The structures of these compounds were determined by spectroscopic analysis. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines...
Source: Phytochemistry Letters - April 11, 2019 Category: Chemistry Source Type: research

Evaluation of anti-melanoma and tyrosinase inhibitory properties of marchantin A, a natural macrocyclic bisbibenzyl isolated from Marchantia species
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Katarzyna Gaweł-Bęben, Paweł Osika, Yoshinori Asakawa, Beata Antosiewicz, Kazimierz Głowniak, Agnieszka LudwiczukAbstractMacrocyclic bisbibenzyl compound, marchantin A, naturally occurring in liverworts belonging to genus Marchantia, was isolated and assessed for their cytotoxicity against two different lines of human skin cells - immortalized human keratinocytes HaCaT and human malignant melanoma cells A375. The purpose of the studies was also to examine the anti-hyperpigmentation effect of marchantin A, especially used in concentrations as...
Source: Phytochemistry Letters - April 11, 2019 Category: Chemistry Source Type: research

Antioxidant activity of five new phenolic compounds from Cirsium creticum subsp. creticum
In this study, five new alkyl catechol derivatives, 1, 2, 3, 4 and 5 were isolated for the first time from Cirsium creticum subsp. creticum L. and their structures were determined by using spectroscopic techniques, including mass spectrometry, 1D and 2D NMR. All of the isolated compounds were primarily evaluated for antioxidant activity against BHA and tocopherol. All compounds which were isolated from C. creticum subsp. creticum exhibited antioxidant activity, however it was noticed that the presence of a pentose sugar increased the antioxidant activity.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - April 10, 2019 Category: Chemistry Source Type: research

Two new polyhydroxylated pentacyclic triterpenes with cytotoxic activities from Manilkara pellegriniana (Sapotaceae)
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Linda D.K. Mogue, Patrick Y. Ango, Ghislain W. Fotso, Renameditswe Mapitse, Deccaux W.F.G. Kapche, Oğuzhan Karaosmanoğlu, Victor Kuete, Ibrahim Demirtas, Samuel O. Yeboah, Hülya Sivas, Ngadjui T. BonaventureAbstractTwo new polyhydroxylated urs-12(13)-ene pentacyclic triterpenes namely 2α, 3α, 19α, 20β, 23-pentahydroxyurs-12-en-28-oic acid (1) and 1β, 2α, 3α, 5, 19α, 24-hexahydroxyurs-11(12), 20(30)-dien-28-oic acid (2) were isolated from the stem bark of Manilkara pellegriniana together with s...
Source: Phytochemistry Letters - April 8, 2019 Category: Chemistry Source Type: research

New cassane diterpenoids from the root bark of Erythrophleum suaveolens
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Jacques Dibi Konan, Barthélemy Koffi Attioua, Claude Landry Ahmont Kablan, Faustin Aka Kabran, Paul Armand Koffi, Sandrine Aka Any-Grah, Sissouma Drissa, Blandine Seon-Meniel, Karine LeBlanc, Jean-Christophe Jullian, Mehdi A. BeniddirAbstractPhytochemical investigation of the methanol extract from the root barks of Erythrophleum suaveolens (Guill. et Perr.) Brenan led to the isolation of four cassane diterpenoid amides and five cassane diterpenoid amines. Among these compounds, two were considered as new structures: 3β-hydroxy-3-meth...
Source: Phytochemistry Letters - April 8, 2019 Category: Chemistry Source Type: research

Phytochemical investigation of Medicago sativa L. extract and its potential as a safe source for the synthesis of ZnO nanoparticles: The proposed mechanism of formation and antimicrobial activity
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): A. Król, V. Railean-Plugaru, P. Pomastowski, B. BuszewskiAbstractThe main goal of present work was the investigation of Medicago sativa L. aqueous extract as a new, safe and accessible agricultural waste source for the synthesis of zinc oxide bio-nanoparticles (ZnO bio-NPs). Secondly, the phytochemical investigation and determination of M. sativa biologically active compounds content before and during the synthesis has led to the proposal of a possible ZnO NPs plant- mediated synthesis mechanism. In this fact, the present research show th...
Source: Phytochemistry Letters - April 8, 2019 Category: Chemistry Source Type: research

Isolation and structure elucidation of secondary metabolites of two Greek endemic Inula species. Biological activities
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Eleftheria Michalakea, Konstantia Graikou, Nektarios Aligiannis, George Panoutsopoulos, Eleftherios Kalpoutzakis, Christos Roussakis, Ioanna ChinouAbstractIn the framework of phytochemical studies on Greek endemic Inula species, Inula candida subsp. candida and Inula candida subsp. decalvans have been analyzed. The aerial parts were extracted with increasing polarity solvents and sixteen secondary metabolites from I. candida subsp. candida and eight from I. candida subsp. decalvans were isolated. From I. candida subsp. decalvans a sesquiterpene ...
Source: Phytochemistry Letters - April 8, 2019 Category: Chemistry Source Type: research

Four new triterpenoids from the bark of Euonymus alatus forma ciliato-dentatus
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Hiroshi Yamashita, Madoka Matsuzaki, Yuria Kurokawa, Takahisa Nakane, Masuo Goto, Kuo-Hsiung Lee, Toshiro Shibata, Hideo Bando, Koji WadaAbstractFour novel lupane-type lupane-type triterpenoids (including three norlupane-type triterpenoids), 17β-hydroxy-28-norlup-20(29)-en-3-one (1), 3β,17β–dihydroxy-28,30-bisnorlupan-20-one (2), 3β-hydroxy-20-oxo-30-norlupan-28-al (3) and lup-20(29)-ene-3,23,30-triol (4), were isolated together with ten known lupane triterpenoids (5˜14) from the bark of Euonymus alatus forma cili...
Source: Phytochemistry Letters - April 8, 2019 Category: Chemistry Source Type: research

Dammarane-type saponins from Gynostemma pentaphyllum and their potential anti-AD activity
This study revealed the potent antagonistic effect of dammarane-type saponins 1 and 6 against Alzheimer’s disease.Graphical abstractTwo undescribed dammarane-type saponins were isolated from Gynostemma pentaphyllum. Their anti-Alzheimer’s Disease (AD) activity was evaluated on a transgenic fly AD model. This study provided two potential candidates for anti-AD agents. (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - April 8, 2019 Category: Chemistry Source Type: research

The unusual conformational preference of N1,N5,N10-tri-p-coumaroylspermidine E-Z isomers from the Japanese apricot tree, Prunus mume, for the (ZZZ)-form
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Shinnosuke Mori, Miki Akamatsu, Hiroshi Fukui, Junko Tsukioka, Katsumi Goto, Nobuhiro HiraiAbstractThe Japanese apricot tree, Prunus mume (Siebold) Siebold & Zucc. cv. Nanko, bears two types of flowers: those with anthers that fluoresce under UV irradiation, and those that do not. The chemical composition of both types of anthers has been investigated: the non-fluorescent anthers contained eight E-Z isomers of N1,N5,N10-tri-p-coumaroylspermidine as major constituents; whereas the fluorescent anthers contained only a limited amount of (ZZZ)-i...
Source: Phytochemistry Letters - April 6, 2019 Category: Chemistry Source Type: research