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The 11 < sup > th < /sup > Conference on metal toxicity and carcinogenesis
Toxicol Appl Pharmacol. 2024 Apr 20:116935. doi: 10.1016/j.taap.2024.116935. Online ahead of print.ABSTRACTMetal exposure is linked to numerous pathological outcomes including cancer, cardiovascular disease, and diabetes. Over the past decades, we have made significant progress in our understanding of how metals are linked to disease, but there is still much to learn. In October 2022, experts studying the consequences of metal exposures met in Montréal, Québec, to discuss recent advances and knowledge gaps for future research. Here, we present a summary of presentations and discussions had at the meeting.PMID:38648938 | ...
Source: Toxicology and Applied Pharmacology - April 22, 2024 Category: Toxicology Authors: Koren K Mann Ke Jian Lu Source Type: research

Dysregulation of adipogenesis and disrupted lipid metabolism by the antidepressants citalopram and sertraline
Toxicol Appl Pharmacol. 2024 Apr 19:116937. doi: 10.1016/j.taap.2024.116937. Online ahead of print.ABSTRACTSelective Serotonin Reuptake Inhibitors (SSRIs) are widely used medications for the treatment of major depressive disorder. However, long-term SSRI use has been associated with weight gain and altered lipid profiles. These findings suggest that SSRIs may have negative effects on metabolism. Exposure to certain chemicals called 'obesogens' are known to promote lipid accumulation and obesity by modulating adipogenesis. Here, we investigated whether citalopram (CIT) and sertraline (SER) interfere with the process of adip...
Source: Toxicology and Applied Pharmacology - April 21, 2024 Category: Toxicology Authors: Deniz Bozdag Jeroen van Voorthuizen Nikita Korpel Sander Lentz Hande Gurer-Orhan Jorke H Kamstra Source Type: research

Protective effects of microbial biosurfactants produced by Bacillus halotolerans and Candida parapsilosis on bleomycin-induced pulmonary fibrosis in mice: Impact of antioxidant, anti-inflammatory and anti-fibrotic properties via TGF- β1/Smad-3 pathway and miRNA-326
Toxicol Appl Pharmacol. 2024 Apr 19:116939. doi: 10.1016/j.taap.2024.116939. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is an irreversible disease which considered the most fatal pulmonary fibrosis. Pulmonary toxicity including IPF is the most severe adverse effect of bleomycin, the chemotherapeutic agent. Based on the fact that, exogenous surfactants could induce alveolar stabilization in many lung diseases, the aim of this study was to explore the effects of low cost biosurfactants, surfactin (SUR) and sophorolipids (SLs), against bleomycin-induced pulmonary fibrosis in mice due to their antioxidan...
Source: Toxicology and Applied Pharmacology - April 21, 2024 Category: Toxicology Authors: Amria M Mousa Mohamed U Nooman Samah S Abbas Sahar M Gebril Mohamed Abdelraof Amr S Al-Kashef Source Type: research

Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1 α/VEGF
In conclusion, ginsenoside CK improved the resistance of gefitinib by regulating the balance of angiogenic factors through down-regulating the HIF-1α/VEGF signaling pathway, providing a theoretical basis for improving the clinical efficacy of gefitinib and applying combined strategies to overcome drug resistance.PMID:38642809 | DOI:10.1016/j.taap.2024.116938 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - April 20, 2024 Category: Toxicology Authors: Xiaoping Song Lina Wang Panpan Cai Ying Xu Qingchao Liu Daidi Fan Source Type: research

AhR signaling modulates Ferroptosis by regulating SLC7A11 expression
Toxicol Appl Pharmacol. 2024 Apr 17:116936. doi: 10.1016/j.taap.2024.116936. Online ahead of print.ABSTRACTThe aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is pivotal in development, metabolic homeostasis, and immune responses. While recent research has highlighted AhR's significant role in modulating oxidative stress responses, its mechanistic relationship with ferroptosis-an iron-dependent, non-apoptotic cell death-remains to be fully elucidated. In our study, we discovered that AhR plays a crucial role in ferroptosis, in part by transcriptionally regulating the expression of the solute...
Source: Toxicology and Applied Pharmacology - April 19, 2024 Category: Toxicology Authors: Ziyue Kou Franklin Tram Tania Colon Yvette Shteynfeld Suwon Noh Fei Chen Byeong Hyeok Choi Wei Dai Source Type: research

Di-n-butyl phthalate induces toxicity in male fetal mouse testicular development by regulating the MAPK signaling pathway
In conclusion, our study provides the first evidence that the MAPK signaling pathway is involved in DBP-induced reproductive toxicity and highlights the importance of JNK1 as a potential target of DBP in inducing reproductive toxicity.PMID:38631520 | DOI:10.1016/j.taap.2024.116933 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - April 17, 2024 Category: Toxicology Authors: Xinwei Wan Xudong Cui Xiang Wang Mingyang Feng Shinan Wei Jia Yu Sha Cheng Heng Luo Jianxin Hu Source Type: research

Exposure to 7,12-dimethylbenz[a]anthracene impacts ovarian DNA damage sensing and repair proteins differently in lean and obese female mice and weight loss may mitigate obesity-induced ovarian dysfunction
Toxicol Appl Pharmacol. 2024 Apr 14:116930. doi: 10.1016/j.taap.2024.116930. Online ahead of print.ABSTRACTObesity impairs oocyte quality, fertility, pregnancy maintenance, and is associated with offspring birth defects. The model ovotoxicant, 7,12-dimethylbenz[a]anthracene (DMBA), causes ovarian DNA damage and follicle loss. Both DMBA-induced chemical biotransformation and the DNA damage response are partially attenuated in obese relative to lean female mice but whether weight loss could improve the DNA damage response to DMBA exposure has not been explored. Thus, at six weeks of age, C57BL/6 J female mice were divided in...
Source: Toxicology and Applied Pharmacology - April 16, 2024 Category: Toxicology Authors: M Estefan ía González-Alvarez Imaobong Inyang Aileen F Keating Source Type: research

Exposure to toxicologically relevant atrazine concentrations impair the glycolytic function of mouse Sertoli cells through the downregulation of lactate dehydrogenase
Toxicol Appl Pharmacol. 2024 Apr 10:116929. doi: 10.1016/j.taap.2024.116929. Online ahead of print.ABSTRACTAtrazine (ATZ), a widely used herbicide with potent endocrine-disrupting properties, has been implicated in hormonal disturbances and fertility issues. Sertoli cells (SCs) play a crucial role in providing mechanical and nutritional support of spermatogenesis. Herein, we aimed to study the effects of environmentally relevant ATZ concentrations on the nutritional support of spermatogenesis provided by SCs. For that, mouse SCs (TM4) were exposed to increasing ATZ concentrations (in μg/L: 0.3, 3, 30, 300, or 3000). After...
Source: Toxicology and Applied Pharmacology - April 12, 2024 Category: Toxicology Authors: Daniela Gomes-Andrade B árbara Guerra-Carvalho David F Carrageta Raquel L Bernardino Patr ícia C Braga Pedro F Oliveira Maria de Lourdes Pereira Marco G Alves Source Type: research

Flavokawain B inhibits NF- κB inflammatory signaling pathway activation in inflammatory bowel disease by targeting TLR2
In this study, we aimed to investigate the effects and mechanisms of FKB targeting TLR2 in IBD. C57BL/6 J mice were treated with 2.5% dextran sulfate sodium (DSS) for 7 days, with administration of FKB or TLR2 inhibitor C29 starting on day 2 to establish the model of IBD. In vitro, bone marrow-derived macrophages (BMDMs) were stimulated with the TLR2 agonist Pam3CSK4 to explore the therapeutic effect of FKB and its pharmacological mechanism. Compared with the model group, the FKB-treated group showed significant reductions in colitis-related injuries in the IBD mouse model, including weight gain, increased colon length and...
Source: Toxicology and Applied Pharmacology - April 7, 2024 Category: Toxicology Authors: Yi Chen Tianyang Jin Mengpei Zhang Bo Hong Bo Jin Chenghong Hu Jiong Wang Yue Chen Lingxi Zhang Yi Wang Lijiang Huang Source Type: research