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Reliability of histologic assessment in patients with eosinophilic oesophagitis
ConclusionThe composite EoEHSS and most component items are associated with substantial reliability when assessed by central pathologists. Future studies should assess responsiveness of the score to change after a therapeutic intervention to facilitate its use in clinical trials. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 20, 2018 Category: Drugs & Pharmacology Authors: M. J. Warners, C. A. Ambarus, A. J. Bredenoord, J. Verheij, G. Y. Lauwers, J. C. Walsh, D. A. Katzka, S. Nelson, T. Viegen, G. T. Furuta, S. K. Gupta, L. Stitt, G. Zou, C. E. Parker, L. M. Shackelton, G. R. D`Haens, W. J. Sandborn, E. S. Dellon, B. G. Fea Tags: ORIGINAL ARTICLE Source Type: research

Systematic review: probiotics in the management of lower gastrointestinal symptoms – an updated evidence‐based international consensus
ConclusionsThis updated review indicates that specific probiotics are beneficial in certain lower GI problems, although many of the new publications did not report benefits of probiotics, possibly due to inclusion of new, less efficacious preparations. Specific probiotics can relieve lower GI symptoms in IBS, prevent diarrhoea associated with antibiotics and H. pylori eradication therapy, and show favourable safety. This study will help clinicians recommend/prescribe probiotics for specific symptoms. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 20, 2018 Category: Drugs & Pharmacology Authors: A. P. S. Hungin, C. R. Mitchell, P. Whorwell, C. Mulligan, O. Cole, L. Agr éus, P. Fracasso, C. Lionis, J. Mendive, J.‐M. Philippart de Foy, B. Seifert, K.‐A. Wensaas, C. Winchester, N. Wit, Tags: SYSTEMATIC REVIEW Source Type: research

Microvesicles in hepatic and peripheral vein can predict nonresponse to corticosteroid therapy in severe alcoholic hepatitis
Summary BackgroundSevere alcoholic hepatitis patients have high mortality and limited response to corticosteroids. Microvesicles reflect cellular stress and disease conditions. AimsTo investigate whether microvesicles are associated with severity, response to steroid therapy and inflammation in severe alcoholic hepatitis. MethodsMicrovesicles originating from different cells were studied pre‐therapy in 101 patients; (71 responder to corticosteroid therapy and 30 nonresponders) and 20 healthy controls. Microvesicles and cells were determined in peripheral and hepatic vein samples using flow cytometry and correlated with o...
Source: Alimentary Pharmacology and Therapeutics - February 20, 2018 Category: Drugs & Pharmacology Authors: S. Sukriti, J. S. Maras, C. Bihari, S. Das, A. K. Vyas, S. Sharma, S. Hussain, S. Shasthry, A. Choudhary, M. Premkumar, D. Kumar, G. Kumar, C. Mukhopadhyay, A. Kumar, N. Trehanpati, P. E. Rautou, R. Moreau, S. K. Sarin Tags: ORIGINAL ARTICLE Source Type: research

Safety, efficacy and pharmacokinetics of vedolizumab in patients with simultaneous exposure to an anti ‐tumour necrosis factor
ConclusionsVedolizumab/anti‐TNF co‐exposure did not generate new safety signals during 14‐weeks induction, nor did it reduce efficacy or alter vedolizumab pharmacokinetics. These observations may aid the design of future co‐biologics trials and also suggest that a deliberate waiting‐interval between anti‐TNF cessation and subsequent vedolizumab initiation may not be warranted. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: S. Ben ‐Horin, B. Ungar, U. Kopylov, A. Lahat, M. Yavzori, E. Fudim, O. Picard, Y. Peled, R. Eliakim, E. Del Tedesco, S. Paul, X. Roblin Tags: ORIGINAL ARTICLE Source Type: research

Corrigendum
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Tags: CORRIGENDUM Source Type: research

Letter: high oral dose of taurine for portal hypertension in cirrhotic patients —some clinical pharmacology considerations
This article is linked to Schwarzer et al paper. To view this article visit https://doi.org/10.1111/apt.14377. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: N. R. Srinivas Tags: LETTER TO THE EDITORS Source Type: research

Letter: mucosal response in discriminating intestinal tuberculosis from Crohn's disease —when to look for it? Authors' reply
This article is linked to Pratap Mouli et al and Sharma et al papers. To view these articles visit https://doi.org/10.1111/apt.13840 and https://doi.org/10.1111/apt.14495. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: V. Pratap Mouli, S. Kedia, V. Ahuja Tags: LETTER TO THE EDITORS Source Type: research

Letter: mucosal response in discriminating intestinal tuberculosis from Crohn's disease —when to look for it?
This article is linked to Partap Mouli et al papers. To view these articles visit https://doi.org/10.1111/apt.13840 and https://doi.org/10.1111/apt.14535. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: V. Sharma, H. S. Mandavdhare, U. Dutta Tags: LETTER TO THE EDITORS Source Type: research

Editorial: biologic therapy for chronic pouchitis – are we beginning to meet the unmet need?
This article is linked to Bär et al paper. To view this paper visit https://doi.org/10.1111/apt.14479. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: M. A. Samaan Tags: INVITED EDITORIALS Source Type: research

Editorial: the portal hypertension puzzle —spleen stiffness evades validation as non‐invasive marker of clinically significant portal hypertension
This article is linked to Elkrief et al paper. To view this article visit https://doi.org/10.1111/apt.14488. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: M. Thiele, A. Krag Tags: INVITED EDITORIALS Source Type: research

Editorial: infliximab trough levels and histological healing in ulcerative colitis —a step towards personalised biologic therapy
This article is linked to Papamichael et al. To view this article visit https://doi.org/10.1111/apt.14458. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: T. Lobaton, M. De Vos Tags: INVITED EDITORIALS Source Type: research

Editorial: sofosbuvir plus daclatasvir for the treatment of hepatitis C —can one size fit all?
This article is linked to El‐Khayat et al paper. To view this article visit https://doi.org/10.1111/apt.14482. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: J. Sun, X. Liang, R. Fan, J. Hou Tags: INVITED EDITORIALS Source Type: research

Editorial: macrophage activation markers predict prognosis and decompensation in patients with cirrhosis —linking gut permeability, inflammation and cirrhosis progression
This article is linked to Rainier et al paper. To view this article visit https://doi.org/10.1111/apt.14474. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: C. Sol é, E. Pose, E. Solà Tags: INVITED EDITORIALS Source Type: research

Editorial: nocebo effect and switching to biosimilars
This article is linked to Schmitz et al paper. To view this article visit https://doi.org/10.1111/apt.14453. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: A. A. Bodegraven, N. W. Boone Tags: INVITED EDITORIALS Source Type: research

Editorial: are additional tests needed to predict sustained virologic response in hepatitis C treated with interferon ‐free direct‐acting antiviral combinations? Authors’ reply
This article is linked to Fourati et al and Ferenci papers. To view these articles visit https://doi.org/10.1111/apt.14478 and https://doi.org/10.1111/apt.14508. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: S. Fourati, J. ‐M. Pawlotsky Tags: INVITED EDITORIALS Source Type: research

Editorial: are additional tests needed to predict sustained virologic response in hepatitis C treated with interferon ‐free direct‐acting antiviral combinations?
This article is linked to Fourati et al and Fourati and Pawlotsky papers. To view these articles visit https://doi.org/10.1111/apt.14478 and https://doi.org/10.1111/apt.14520. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: P. Ferenci Tags: INVITED EDITORIALS Source Type: research

Editorial: the post ‐Helicobacter stomach—not the same for cohorts and individuals. Authors’ reply
This article is linked to Hwang et al and Genta papers. To view these articles visit https://doi.org/10.1111/apt.14424 and https://doi.org/10.1111/apt.14491. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: N. Kim, Y. J. Hwang Tags: INVITED EDITORIALS Source Type: research

Editorial: the post ‐Helicobacter stomach—not the same for cohorts and individuals
This article is linked to Hwang et al and Kim and Hwang papers. To view these articles visit https://doi.org/10.1111/apt.14424 and https://doi.org/10.1111/apt.14524. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: R. M. Genta Tags: INVITED EDITORIALS Source Type: research

Editorial: restoring therapeutic infliximab drug levels in patients with loss of response —pharmacokinetics and anti‐drug antibodies as useful guidance tools
This article is linked to Dreesen et al paper. To view this article visit https://doi.org/10.1111/apt.14452. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: S. Ben ‐Horin Tags: INVITED EDITORIALS Source Type: research

Issue Information
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Impact of controlled attenuation parameter on detecting fibrosis using liver stiffness measurement
ConclusionsLiver stiffness measurement values below aetiology‐specific cut‐offs are very useful for ruling out cirrhosis, and to a lesser extent for ruling out significant fibrosis. In the case of the latter, Controlled Attenuation Parameter can improve interpretation slightly. Even if cut‐offs are very high, liver stiffness measurements are not very reliable for ruling in fibrosis or cirrhosis. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: T. Karlas, D. Petroff, M. Sasso, J. ‐G. Fan, Y.‐Q. Mi, V. de Lédinghen, M. Kumar, M. Lupsor‐Platon, K.‐H. Han, A. C. Cardoso, G. Ferraioli, W.‐K. Chan, V. W.‐S. Wong, R. P. Myers, K. Chayama, M. Friedrich‐Rust, M. Beaugrand, F. Shen, J.‐B Tags: ORIGINAL ARTICLE Source Type: research

Systematic review: the natural history of alpha ‐1 antitrypsin deficiency, and associated liver disease
DiscussionThe clinical course of liver disease in individuals with AATD remains poorly understood, but affects about 10% of those with AATD. More research is required to identify those patients at risk of developing liver disease at an early stage, and to provide alternative treatments to liver transplantation. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 15, 2018 Category: Drugs & Pharmacology Authors: S. A. Townsend, R. G. Edgar, P. R. Ellis, D. Kantas, P. N. Newsome, A. M. Turner Tags: SYSTEMATIC REVIEW Source Type: research

Systematic review with meta ‐analysis: the worldwide prevalence of Helicobacter pylori infection
ConclusionsThe observed differences between countries appear to be due to economic and social conditions. H. pylori infection can be a benchmark for the socioeconomic and health status of a country. Further studies are suggested to investigate the natural history of the acquisition of H. pylori infection from childhood into adult life. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 12, 2018 Category: Drugs & Pharmacology Authors: M. Zamani, F. Ebrahimtabar, V. Zamani, W. H. Miller, R. Alizadeh ‐Navaei, J. Shokri‐Shirvani, M. H. Derakhshan Tags: SYSTEMATIC REVIEW WITH META ‐ANALYSIS Source Type: research

Review article: predictors of response to vedolizumab and ustekinumab in inflammatory bowel disease
Summary BackgroundIncreased knowledge of pathways involved in the pathogenesis of IBD has led to the development of new treatment options for Crohn's disease (CD) and ulcerative colitis (UC). Two new biological agents have been recently approved for IBD: vedolizumab and ustekinumab. They have different therapeutic targets (α4β7 integrin for vedolizumab and interleukin‐12/23 pathways for ustekinumab) than the primary biological class, anti‐tumour necrosis factor alpha (anti‐TNF) agents. As the armamentarium for IBD increases in coming years, it will become important to understand factors associated with res...
Source: Alimentary Pharmacology and Therapeutics - February 12, 2018 Category: Drugs & Pharmacology Authors: A. Barr é, J.‐F. Colombel, R. Ungaro Tags: REVIEW ARTICLE Source Type: research

Viral eradication reduces both liver stiffness and steatosis in patients with chronic hepatitis C virus infection who received direct ‐acting anti‐viral therapy
Summary BackgroundWhether direct‐acting anti‐viral therapy can reduce liver fibrosis and steatosis in patients with chronic hepatitis C virus (HCV) infection is unclear. AimsTo evaluate changes in liver stiffness and steatosis in patients with HCV who received direct‐acting anti‐viral therapy and achieved sustained virological response (SVR). MethodsA total of 198 patients infected with HCV genotype 1 or 2 who achieved SVR after direct‐acting anti‐viral therapy were analysed. Liver stiffness as evaluated by magnetic resonance elastography, steatosis as evaluated by magnetic resonance imaging‐determined proton...
Source: Alimentary Pharmacology and Therapeutics - February 9, 2018 Category: Drugs & Pharmacology Authors: T. Tada, T. Kumada, H. Toyoda, Y. Sone, K. Takeshima, S. Ogawa, T. Goto, A. Wakahata, M. Nakashima, M. Nakamuta, J. Tanaka Tags: ORIGINAL ARTICLE Source Type: research

Letter: nutritional benefits of rifaximin in cirrhotic patients
This article is linked to Kang et al paper. To view this article visit https://doi.org/10.1111/apt.14275. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 7, 2018 Category: Drugs & Pharmacology Authors: P. Borentain, K. Rouabah, G. Allard, E. Ressiot, R. Gerolami Tags: LETTER TO THE EDITORS Source Type: research

Letter: what gastroenterologists should know about VSL#3
This article is linked to McIlroy et al paper. To view this article visit https://doi.org/10.1111/apt.14384. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 7, 2018 Category: Drugs & Pharmacology Authors: C. De Simone Tags: LETTER TO THE EDITORS Source Type: research

Letter: the efficacy and safety of rifaximin for the prophylaxis of spontaneous bacterial peritonitis in cirrhotic patients
This article is linked to Goel et al paper. To view this article visit https://doi.org/10.1111/apt.14361. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 7, 2018 Category: Drugs & Pharmacology Authors: J. Zhao, Y. Zhang, H. Tian, H. Sun, C. Liang Tags: LETTER TO THE EDITORS Source Type: research

Letter: innovative use of the alfapump system to treat small hepatocellular carcinoma – authors' reply
This article is linked to Stirnimann et al and Weil et al papers. To view these articles visit https://doi.org/10.1111/apt.14331 and https://doi.org/10.1111/apt.14440. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 7, 2018 Category: Drugs & Pharmacology Authors: G. Stirnimann, A. De Gottardi Tags: LETTER TO THE EDITORS Source Type: research

Letter: innovative use of the alfapump system to treat a small hepatocellular carcinoma
This article is linked to Stirnimann et al and Stirnimann and De Gottardi papers. To view these articles visit https://doi.org.10.1111/apt.14331 and https://doi.org.10.1111/apt.14500. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 7, 2018 Category: Drugs & Pharmacology Authors: D. Weil, P. ‐Y. Christmann, N. Sailley, T. Thévenot Tags: LETTER TO THE EDITORS Source Type: research

Editorial: looking for patients at risk of cirrhosis in the general population —many needles in a haystack
This article is linked to Harman et al paper. To view this article visit https://doi.org/10.1111/apt.14463. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 7, 2018 Category: Drugs & Pharmacology Authors: J. Ampuero, M. Romero ‐Gómez Tags: INVITED EDITORIAL Source Type: research

Editorial: a novel technology for the assessment of non ‐alcoholic fatty liver disease
This article is linked to Eddowes et al paper. To view this article visit https://doi.org/10.1111/apt.14469. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 7, 2018 Category: Drugs & Pharmacology Authors: G. Ferraioli Tags: INVITED EDITORIAL Source Type: research

Editorial: weighing the global risk of cancer with thiopurines in inflammatory bowel disease —Authors' reply
This article is linked to Lu et al and Laharie and Riviere papers. To view these articles visit https://doi.org/10.1111/apt.14436 and https://doi.org/10.1111/apt.14475. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 7, 2018 Category: Drugs & Pharmacology Authors: X. Y. Qiu, M. J. Lu, H. J. Zhang Tags: INVITED EDITORIAL Source Type: research

Editorial: weighing the global risk of cancer with thiopurines in inflammatory bowel disease
Linked content This is article is linked to Lu et al and Qui et al papers. To view these articles visit https://doi.org/10.1111/apt.14436 and https://doi.org/10.1111/apt.14498. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 7, 2018 Category: Drugs & Pharmacology Authors: D. Laharie, P. Riviere Tags: INVITED EDITORIAL Source Type: research

Issue Information
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 7, 2018 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Review article: the evidence that vancomycin is a therapeutic option for primary sclerosing cholangitis
ConclusionVancomycin is one of the most studied antibiotics used in the treatment of PSC with promising results. There is not currently sufficient evidence to support treatment recommendations. Further research is needed to establish if vancomycin is a PSC treatment. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 7, 2018 Category: Drugs & Pharmacology Authors: J. L. Damman, E. A. Rodriguez, A. H. Ali, C. W. Buness, K. L. Cox, E. J. Carey, K. D. Lindor Tags: REVIEW ARTICLE Source Type: research

Fibrosis in ulcerative colitis is directly linked to severity and chronicity of mucosal inflammation
Summary BackgroundFibrosis in ulcerative colitis has remained largely unexplored despite its clinical implications. AimsThis cross‐sectional study was aimed at characterising the presence, anatomical location and degree of ulcerative colitis‐associated fibrosis and its possible link to clinical parameters. MethodsSeven hundred and six individual tissue cross‐sections derived every 10 cm along the length of 89 consecutive Ulcerative colitis colectomy specimens were examined and compared to Crohn's disease colitis, diverticular disease and uninvolved areas from colorectal cancer patients. Degree of inflammation, fibros...
Source: Alimentary Pharmacology and Therapeutics - February 6, 2018 Category: Drugs & Pharmacology Authors: I. O. Gordon, N. Agrawal, E. Willis, J. R. Goldblum, R. Lopez, D. Allende, X. Liu, D. Y. Patil, L. Yerian, F. El ‐Khider, C. Fiocchi, F. Rieder Tags: ORIGINAL ARTICLE Source Type: research

Emergency department utilisation for inflammatory bowel disease in the United States from 2006 to 2014
ConclusionsThe number of ED visits due to IBD and associated charges have continued to rise, while the rates of in‐patient hospitalisations referred from the ED and surgeries have decreased. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 1, 2018 Category: Drugs & Pharmacology Authors: S. Ballou, W. Hirsch, P. Singh, V. Rangan, J. Nee, J. Iturrino, T. Sommers, J. Zubiago, N. Sengupta, A. Bollom, M. Jones, A. C. Moss, S. N. Flier, A. S. Cheifetz, A. Lembo Tags: ORIGINAL ARTICLE Source Type: research

Betablockers do not increase efficacy of band ligation in primary prophylaxis but they improve survival in secondary prophylaxis of variceal bleeding
Summary BackgroundEndoscopic band ligation (EBL) is used for primary (PP) and secondary prophylaxis (SP) of variceal bleeding. Current guidelines recommend combined use of non‐selective beta‐blockers (NSBBs) and EBL for SP, while in PP either NSBB or EBL should be used. AimTo assess (re‐)bleeding rates and mortality in cirrhotic patients receiving EBL for PP or SP for variceal bleeding. Methods(Re‐)bleeding rates and mortality were retrospectively assessed with and without concomitant NSBB therapy after first EBL in PP and SP. ResultsSeven hundred and sixty‐six patients with oesophageal varices underwent EBL from...
Source: Alimentary Pharmacology and Therapeutics - February 1, 2018 Category: Drugs & Pharmacology Authors: N. Pfisterer, C. Dexheimer, E. ‐M. Fuchs, T. Bucsics, P. Schwabl, M. Mandorfer, I. Gessl, L. Sandrieser, L. Baumann, F. Riedl, B. Scheiner, T. Pachofszky, W. Dolak, C. Schrutka‐Kölbl, A. Ferlitsch, M. Schöniger‐Hekele, M. Peck‐Radosavljevic, M. Tags: ORIGINAL ARTICLE Source Type: research

Early vedolizumab trough levels predict mucosal healing in inflammatory bowel disease: a multicentre prospective observational study
ConclusionEarly therapeutic drug monitoring might improve timely detection of vedolizumab‐treated patients in need for an intensified dosing regimen. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - January 31, 2018 Category: Drugs & Pharmacology Authors: W. Yacoub, N. Williet, L. Pouillon, T. Di ‐Bernado, M. De Carvalho Bittencourt, S. Nancey, A. Lopez, S. Paul, C. Zallot, X. Roblin, L. Peyrin‐Biroulet Tags: Original Article Source Type: research

Psychometric properties of the PROMIS short form measures in a U.S. cohort of 961 patients with chronic hepatitis C prescribed direct acting antiviral therapy
Summary BackgroundTo better understand symptoms experienced by patients infected with chronic hepatitis C virus (HCV), valid and reliable patient‐reported outcome (PRO) measures are needed. AimTo assess the reliability and validity of 10 patient‐reported outcomes measurement information system (PROMIS) measures and the Headache Impact Test‐6 (HIT‐6) in a large national sample of patients with HCV. MethodsPre‐treatment data from 961 patients with HCV starting direct acting antiviral therapy at 11 U.S. liver centers were analyzed. Internal reliability was evaluated using Cronbach's alpha coefficient; frequency dist...
Source: Alimentary Pharmacology and Therapeutics - January 29, 2018 Category: Drugs & Pharmacology Authors: D. M. Evon, J. Amador, P. Stewart, B. B. Reeve, A. S. Lok, R. K. Sterling, A. M. Di Bisceglie, N. Reau, M. Serper, S. Sarkar, J. K. Lim, C. E. Golin, M. W. Fried Tags: ORIGINAL ARTICLE Source Type: research

Hepatitis C virus re ‐treatment in the era of direct‐acting antivirals: projections in the USA
ConclusionsEven in the era of highly effective DAAs, a significant number of patients will fail to achieve SVR and will require re‐treatment options. Timely and effective re‐treatment is essential to prevent the long‐term sequelae of HCV. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - January 29, 2018 Category: Drugs & Pharmacology Authors: J. Chhatwal, Q. Chen, T. Ayer, E. D. Bethea, F. Kanwal, K. V. Kowdley, X. Wang, M. S. Roberts, S. C. Gordon Tags: ORIGINAL ARTICLE Source Type: research

Von Willebrand factor indicates bacterial translocation, inflammation, and procoagulant imbalance and predicts complications independently of portal hypertension severity
Summary BackgroundElevated plasma von Willebrand factor antigen (vWF) has been shown to indicate the presence of clinically significant portal hypertension, and thus, predicts the development of clinical events in patients with cirrhosis. AimTo investigate the impact of bacterial translocation and inflammation on vWF, as well as the association between vWF and procoagulant imbalance. Moreover, we assessed whether vWF predicts complications of cirrhosis, independent of the severity of portal hypertension. MethodsOur study population comprised 225 patients with hepatic venous pressure gradient (HVPG) ≥ 10 m...
Source: Alimentary Pharmacology and Therapeutics - January 29, 2018 Category: Drugs & Pharmacology Authors: M. Mandorfer, P. Schwabl, R. Paternostro, K. Pomej, D. Bauer, J. Thaler, C. Ay, P. Quehenberger, M. Fritzer ‐Szekeres, M. Peck‐Radosavljevic, M. Trauner, T. Reiberger, A. Ferlitsch, Tags: ORIGINAL ARTICLE Source Type: research

Vedolizumab in patients with concurrent primary sclerosing cholangitis and inflammatory bowel disease does not improve liver biochemistry but is safe and effective for the bowel disease
ConclusionVedolizumab treatment in patients with PSC and IBD did not improve liver biochemistry but was associated with improvement in bowel disease and a favourable safety profile. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - January 29, 2018 Category: Drugs & Pharmacology Authors: B. Christensen, D. Micic, P. R. Gibson, A. Yarur, E. Bellaguarda, P. Corsello, J. N. Gaetano, J. Kinnucan, V. L. Rao, S. Reddy, S. Singh, J. Pekow, D. T. Rubin Tags: ORIGINAL ARTICLE Source Type: research

Symptom ‐associated probability does not reliably distinguish functional heartburn from reflux hypersensitivity
ConclusionIn PPI‐refractory GERD, SAP cannot accurately distinguish reflux hypersensitivity from functional oesophageal symptoms. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - January 26, 2018 Category: Drugs & Pharmacology Authors: Y. Choksi, J. C. Slaughter, R. Sharda, T. Higginbotham, P. Lal, M. F. Vaezi Tags: ORIGINAL ARTICLE Source Type: research

Review article: the physiological effects and safety of peppermint oil and its efficacy in irritable bowel syndrome and other functional disorders
ConclusionPeppermint oil is a natural product which affects physiology throughout the gastrointestinal tract, has been used successfully for several clinical disorders, and appears to have a good safety profile. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - January 26, 2018 Category: Drugs & Pharmacology Authors: B. P. Chumpitazi, G. L. Kearns, R. J. Shulman Tags: REVIEW ARTICLE Source Type: research

Phenotype and natural history of elderly onset inflammatory bowel disease: a multicentre, case ‐control study
Summary BackgroundOnset during old age has been reported in upto 10% of total cases of inflammatory bowel disease (IBD). AimTo evaluate phenotypic characteristics and the use of therapeutic resources in patients with elderly onset IBD. MethodsCase‐control study including all those patients diagnosed with IBD over the age of 60 years since 2000 who were followed‐up for>12 months, identified from the IBD databases. Elderly onset cases were compared with IBD patients aged 18 to 40 years at diagnosis, matched by year of diagnosis, gender and type of IBD (adult‐onset). ResultsOne thousand three hundred and seventy‐fo...
Source: Alimentary Pharmacology and Therapeutics - January 25, 2018 Category: Drugs & Pharmacology Authors: M. Ma ñosa, M. Calafat, R. Francisco, C. García, M. J. Casanova, P. Huelín, M. Calvo, J. Tosca, L. Fernández‐Salazar, C. Arajol, Y. Zabana, G. Bastida, J. Hinojosa, L. Márquez, M. Barreiro‐de‐Acosta, X. Calvet, D. Monfort, M. R. Gómez‐Garcia Tags: ORIGINAL ARTICLE Source Type: research

Long ‐term effect of medical treatment of diarrhoea in 594 patients with SeHCAT scan diagnosed bile acid malabsorption from 2003 to 2016; a retrospective study
ConclusionMany patients with bile acid diarrhoea continue to have bothersome diarrhoea in spite of correct diagnosis and treatment. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - January 25, 2018 Category: Drugs & Pharmacology Authors: B. Damsgaard, H. R. Dalby, K. Krogh, S. M. D. J ørgensen, A. K. Arveschough, J. Agnholt, J. F. Dahlerup, S. P. Jørgensen Tags: ORIGINAL ARTICLE Source Type: research

Systematic review with meta ‐analysis: de novo non‐alcoholic fatty liver disease in liver‐transplanted patients
ConclusionsPatients undergoing liver transplant are more prone to experience diabetes, hypertension or dyslipidaemia, and NAFLD may be an important element in this context. In this study, we show how the prevalence of NASH tends to remain significant and similar to the general population. Moreover, this study suggests a possible association with specific transplant indications. Further studies are required to confirm these findings. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - January 23, 2018 Category: Drugs & Pharmacology Authors: G. Losurdo, A. Castellaneta, M. Rendina, S. Carparelli, G. Leandro, A. Di Leo Tags: SYSTEMATIC REVIEW WITH META ‐ANALYSIS Source Type: research