Effect of Korean Magnolia obovata Extract on Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cells
AbstractObjectiveTo investigate the effects of KoreanMagnolia obovata crude extract (KME) on plateletderived growth factor (PDGF)-BB-induced proliferation and migration of vascular smooth muscle cells (VSMCs).MethodsKME composition was analyzed by high-performance liquid chromatography (HPLC). VSMCs were isolated from the aorta of a Sprague-Dawley rat, incubated in serum free-Dulbecco ’s modified Eagle’s medium in the presence or absence of KME (10, 30, 100, and 300 μg/mL), then further treated with PDGF-BB (10 ng/mL). VSMC proliferation was detected using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazo...
Source: Chinese Journal of Integrative Medicine - September 28, 2019 Category: Internal Medicine Source Type: research

Exploration of Stratified Evidence Scoring Method of Acupuncture Clinical Practice Guidelines
AbstractDue to its own internal laws of development, Chinese medicine (CM) seems more inclined to empirical medicine in a relatively long historical period. It is considered to be lacking objective and unified clinical practice guidelines (CPGs), and the difficulties in diagnosis and therapeutic effect evaluation comes with it, have restricted its further inheritance, development and international communication. Over the years, our research group has been committed to improving the standardization theory and methodology of CM, also perfecting relative techniques for further application, which are all based on the stratifie...
Source: Chinese Journal of Integrative Medicine - September 28, 2019 Category: Internal Medicine Source Type: research

Correlation between Chinese Medicine Constitution and Skin Types: A Study on 187 Japanese Women
ConclusionsOur findings supported the “Constitution-Skin Correlated theory” in CM. Understanding of the association between skin conditions and the body constitutions might be helpful to explore more individualized treatment options for skin care and dermatological diseases through modifications of the unique body constitutions usin g CM modalities. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 23, 2019 Category: Internal Medicine Source Type: research

Ethnopharmacology, Phytochemistry, Pharmacology, Toxicology and Clinical Applications of Radix Astragali
AbstractRadix Astragali (RA), a traditional Chinese medicine from the dried root ofAstragalus species, is widely distributed throughout the temperate regions of the world. The major bioactive constituents of RA are triterpene glycosides, flflavonoids, saponins, and alkaloids, and these compounds mostly exert pharmacological activities on the cardiovascular, immune, respiratory, and hepatic systems. This review summarizes the recent studies on RA and provides a comprehensive summary regarding the status of resources, ethnopharmacology, phytochemistry, pharmacology, toxicology, clinical application, and patent release of RA....
Source: Chinese Journal of Integrative Medicine - September 9, 2019 Category: Internal Medicine Source Type: research

Research Progress in Astragalus Membranaceus and Its Active Components on Immune Responses in Liver Fibrosis
This article reviews the action mechanism of immune cells on liver fifibrosis and the effect ofAstragalus membranaeus and its active components on immune cells. In-depth study of interaction between immune cells and HSCs on the pathogenesis of liver fifibrosis, and the regulatory effect ofAstragalus membranaeus and its active components on immune mechanism will provide new insights in the treatment of liver fifibrosis. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 9, 2019 Category: Internal Medicine Source Type: research

Association between Chinese Medicine Therapy and Survival Outcomes in Postoperative Patients with NSCLC: A Multicenter, Prospective, Cohort Study
ConclusionsLonger duration of CM therapy could be considered a protective factor of cancer recurrence and metastasis. CM treatment is associated with improving survival outcomes of postoperative NSCLC patients in China. (Registration No. ChiCTR-OOC-14005398) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 31, 2019 Category: Internal Medicine Source Type: research

Syndrome Differentiation of Chinese Medicine in Mars 500 Long-Term Closed Environment
ConclusionThe research has verified the effectiveness of CM syndrome differentiation based on the four diagnostic methods, which should serve as a solid foundation for observation, monitoring, and intervention in regard to the health conditions of astronauts in long-term space flights in the future. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 27, 2019 Category: Internal Medicine Source Type: research

Combination Therapy of Acitretin Capsules and Chinese Herb for Patients with Lichen Planus Pigmentosus-Inversus
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 24, 2019 Category: Internal Medicine Source Type: research

Pathological Observation of Blood Stasis Syndrome in Non-diabetic Peripheral Neuropathies: A Retrospective Analysis Based on Nerve Biopsy
ConclusionsBBS was common in non-diabetic peripheral neuropathies. The nerves exhibited ischemic alteration of primary axon degeneration and secondary demyelination. The interstitial tissue revealed microcirculation impairment, blood-nerve barrier disturbance, amyloid deposition and proliferation changes. The high prevalence of qi deficiency also highlights the therapy of promotion of blood circulation and removal of blood stasis. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 24, 2019 Category: Internal Medicine Source Type: research

Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment
Conclusion: LFS of CM formulation could effectively alleviate MPE and improve the QOL of cancer patients. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 24, 2019 Category: Internal Medicine Source Type: research

Da-Cheng-Qi Decoction ( 大承气汤) Combined with Lactobacillus Acidophilus Improves Gastrointestinal Function of Traumatic Brain-Injured Model Mice
AbstractObjectiveTo investigate the effects of Da-Cheng-Qi Decoction (DCQD, 大承气汤) combined withLactobacillus acidophilus (LA) on the recovery of gastrointestinal (GI) function in traumatic brain-injured (TBI) mice.MethodsA total of 150 male C57BL/6 mice were randomly divided into sham-injury, normal saline (NS), DCQD (0.4 mL/day), LA ( ⩾1 × 1010 cfu/day LA), DCQD+LA (LA administration at the same dosage after 4 h of feeding DCQD), and ½ DCQD+LA groups (LA administration at the same dosage after 4 h of feeding ½ DCQD dose) by a random number table, 5–8 mice in each group. The sever TBI mo...
Source: Chinese Journal of Integrative Medicine - August 24, 2019 Category: Internal Medicine Source Type: research

Met-Controlled Allosteric Module of Neural Generation as A New Therapeutic Target in Rodent Brain Ischemia
AbstractObjectiveTo investigate a Met-controlled allosteric module (AM) of neural generation as a potential therapeutic target for brain ischemia.MethodsWe selected Markov clustering algorithm (MCL) to mine functional modules in the related target networks. According to the topological similarity, one functional module was predicted in the modules of baicalin (BA), jasminoidin (JA), cholic acid (CA), compared with I/R model modules. This functional module included three genes: Inppl1, Met and Dapk3 (IMD). By gene ontology enrichment analysis, biological process related to this functional module was obtained. This functiona...
Source: Chinese Journal of Integrative Medicine - August 15, 2019 Category: Internal Medicine Source Type: research

Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells
AbstractObjectiveTo evaluate the effects of combination ofRadix Astragali (RA) andRadix Salviae Miltiorrhizae (RS) on kidney of spontaneously hypertensive rats (SHRs) and renal intrinsic cells.MethodsSHRs were intragastrically administrated with RA (5.09 g/kg) and RS (2.55 g/kg) either alone or with combination for 4 weeks; valsartan (13.35 mg/kg) was used as a positive control. Blood pressure and renal ultrasonography were monitored periodically. The biomarkers [microalbumin (mALB), cystatin ^C, angiotensin II (Ang II), interleukin-1 beta (IL-1 β), and β2-microglobulin (β2-Mg), etc.] in serum and urine were...
Source: Chinese Journal of Integrative Medicine - August 5, 2019 Category: Internal Medicine Source Type: research

Comparison between Xingnaojing Injection ( 醒脑静注射液) and Naloxone in Treatment of Acute Alcohol Intoxication: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
ConclusionsLow quality of evidence showed XNJ may have equal effect as naloxone and may achieve better effect as add-on intervention with naloxone for patients with AAI. We failed to evaluate the safety of XNJ Injection due to the insufficient evidence in this review. Registration number. in PROSPERO (No. CRD42018087804) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 5, 2019 Category: Internal Medicine Source Type: research

A Reflection on the 2017 Nobel Prize for Physiology and Chinese Medicine
AbstractResearch on the molecular mechanisms controlling circadian rhythm in Western medicine is comparable to the study of a day-night rhythm in Chinese medicine (CM), as also focus on the same life phenomenon. By comparing the two, this paper elaborates on the differences between them in their respective issues of consciousness, ways of thinking, research methods and research results. Relatively speaking, Nobel Prize research has a stronger sense of the problems and concerns about the essence of “what”, while CM focuses on “how a thing functions”. The former mainly adopts experimental and mathemat...
Source: Chinese Journal of Integrative Medicine - August 5, 2019 Category: Internal Medicine Source Type: research

Benefits and Safety of Tripterygium Glycosides and Total Glucosides of Paeony for Rheumatoid Arthritis: An Overview of Systematic Reviews
ConclusionsTG and TGP might be 2 potentially effective complementary and alternative drugs for patients with RA. Nevertheless, due to gonad toxicity, TG should only be considered in elderly patients or patients without reproductive needs. More evidence from high quality RCTs and SRs is warranted to support the use of TG and TGP for RA patients. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 5, 2019 Category: Internal Medicine Source Type: research

Systems Pharmacology Uncovers Multiple Mechanisms of Erxian Decoction ( 二仙汤) for Treatment of Premature Ovarian Failure
ConclusionsThe systems pharmacology approach is a comprehensive system that was used to elucidate the pharmacological mechanism of EXD as a treatment for POF. The results of this study will also facilitate the application of traditional medicine in modern treatment strategies. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 5, 2019 Category: Internal Medicine Source Type: research

Effect and Safety of CX-DZ-II Intelligent Electroacupuncture Therapeutic Instrument for Neck Pain Caused by Cervical Spondylos: Study Protocol for A Randomized Controlled Trial
This study will evaluate the effect and safety of the CX-DZ-II intelligent electroacupuncture therapeutic instrument in comparison with a pre-existing non-intelligent instrument in the treatment of neck pain caused by CS. The results will hopefully demonstrate a more optimal electroacupuncture instrument for the treatment of neck pain. (Trial registration No. gov NCT03005301). (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 1, 2019 Category: Internal Medicine Source Type: research

Effect and Safety of Huannao Yicong Formula ( 还脑益聪方) in Patients with Mild-to-Moderate Alzheimer’s Disease: A Randomized, Double-Blinded, Donepezil-Controlled Trial
AbstractObjectiveTo assess the effect and safety of Huannao Yicong Formula ( 还脑益聪方, HYF) in the treatment of patients with mild-to-moderate Alzheimer’s disease (AD).MethodsSixty patients with mild-tomoderate AD were evenly randomized into HYF group and donepezil group with the random number method. Patients in the HYF group took 5 g of HYF granules twice daily and 5 mg placebo of donepezil once daily. Patients in the donepezil group took 5 mg donepezil once daily and 5 g placebo of HYF granules twice daily. The intervention lasted for 6 months. Clinical researchers, participants and statisticians were blind...
Source: Chinese Journal of Integrative Medicine - July 22, 2019 Category: Internal Medicine Source Type: research

Effects of Acupuncture on Alzheimer ’s Disease: Evidence from Neuroimaging Studies
AbstractAs the worldwide population ages, the prevalence of Alzheimer's disease (AD) increases. However, the results of promising medications have been unsatisfactory. Chinese acupuncture has a long history of treating dementia, but lack of evidence from well-designed randomized controlled trials that validate its efficacy and safety, as well as its lack of clear underlying mechanisms, contribute to its limited application in clinical practice. In recent years, brain imaging technologies, such as functional magnetic resonance imaging and positron emission tomography, have been used to assess brain responses to acupuncture ...
Source: Chinese Journal of Integrative Medicine - July 22, 2019 Category: Internal Medicine Source Type: research

Commentary for Sequential Therapy Based on Evolvement of Patterns: A New Model for Treatment of Alzheimer ’s Disease
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 22, 2019 Category: Internal Medicine Source Type: research

Effect and Safety of Guanxinning Tablet ( 冠心宁片) for Stable Angina Pectoris Patients with Xin (Heart)-Blood Stagnation Syndrome: A Randomized, Multicenter, Placebo-Controlled Trial
AbstractObjectiveTo investigate the effect and safety of Guanxinning Tablet ( 冠心宁片, GXN) for the treatment of stable angina pectoris patients with Xin (Heart)-blood stagnation syndrome (XBSS).MethodsOne hundred and sixty stable angina pectoris patients with XBSS were randomly assigned to receive GXN (80 cases) or placebo (80 cases, Guanxinning simulation tablets, mainly composed of lactose), 4 tablets (0.38 g/tablet), thrice daily for 12 weeks. After treatment, an exercise stress test (treadmill protocol), Chinese medicine (CM) syndrome score, electrocardiogram (ECG), and nitroglycerin withdrawal rate were evaluate...
Source: Chinese Journal of Integrative Medicine - July 13, 2019 Category: Internal Medicine Source Type: research

Changes in Cold and Hot Syndrome and Gastrointestinal Bacterial Community Structure in Mice by Intervention with Food of Different Nature
AbstractObjectiveTo reveal the effect of foods with different natures on cold or hot syndrome and gastrointestinal bacterial community structure in mice.MethodsForty-five 6-week-old male ICR Kunming mice of clean grade were divided into 5 groups, 9 per group, including the control (CK), hot nature herbs (HM), Hong Qu glutinous rice wine (RW), tea rice wine (TW), and cold nature herbs (CM) groups. Distilled water or corresponding herbs were administered to mice (0.01 mL/g body weight) in the 5 groups by gastric infusion respectively, once daily for 28 d. Appearance, behavior, and serum biochemical indicators, including 5-hy...
Source: Chinese Journal of Integrative Medicine - July 13, 2019 Category: Internal Medicine Source Type: research

Post-marketing Re-evaluation of Tongxiening Granules ( 痛泻宁颗粒) in Treatment of Diarrhea-Predominant Irritable Bowel Syndrome: A Multi-center, Randomized, Double-Blind, Double-Dummy and Positive Control Trial
ConclusionTongxiening Granules could relieve the symptoms of patients with IBS-D and the treatment effect was comparable to pinaverium bromide. (No. ChiCTR-IPR-15006415) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 10, 2019 Category: Internal Medicine Source Type: research

Relation of Blood Arsenic Concentration with Effect and Safety of Arsenic-Containing Qinghuang Powder ( 青黄散) in Patients with Myelodysplastic Syndrome
AbstractObjectiveTo investigate the relation of blood arsenic concentration (BAC) with clinical effect and safety of arsenic-containing Qinghuang Powder ( 青黄散, QHP) in patients with myelodysplastic syndrome (MDS).MethodsTotally 163 patients with MDS were orally treated with QHP for 2 courses of treatment, 3 months as 1 course. The BACs of patients were detected by atomic fluorescence spectrophotometry at 1, 3, and 6 months during the treatment, and the effective rate, hematological improvement and safety in patients after treatment with QHP were analyzed.ResultsAfter 2 courses of treatment, the total effective rate w...
Source: Chinese Journal of Integrative Medicine - July 1, 2019 Category: Internal Medicine Source Type: research

Therapeutic Effect of Ershen Pill ( 二神丸) Extract on Pi (Spleen)-Shen (Kidney) Yang Deficiency-Induced Diarrhea in Rat Model
AbstractObjectiveTo investigate whether Ershen Pill (ESP, 二神丸) could alleviate the symptom of Pi (Spleen)-Shen (Kidney) yang deficiency (PSYD)-induced diarrhea in rat model and explore its anti-diarrhea mechanism.MethodsSeventy-five Sprague-Dawley rats were divided into 5 groups by a random number table, including control, positive, model, low-dose (LD) and high-dose (HD) ESP groups, 15 rats in each group. All the rats, except those in the control group, were developed PSYD induced-diarrhea based on its pathology and etiology. The rats in positive, LD and HD ESP groups were treated with Shenling Baizhu Pill ( 参苓...
Source: Chinese Journal of Integrative Medicine - July 1, 2019 Category: Internal Medicine Source Type: research

Research Progress on Chinese Medicine Immunomodulatory Intervention for Chronic Primary Immune Thrombocytopenia: Targeting Cellular Immunity
AbstractChronic primary immune thrombocytopenia (CITP) is the most common acquired autoimmune disease that seriously threaten the physical and mental health of patients. Compared with Western medicine treatment, the intervention and treatment of Chinese medicine (CM) has shown certain therapeutic advantages. This paper reviewed the new pathogenesis progress on T cell immune abnormality in CITP, and CM studies on interferes effects of cellular immune regulation of CITP in recent years. Qi deficiency failing to control blood and internal obstruction of blood stasis are the two common types of CM syndromes in CITP patients, t...
Source: Chinese Journal of Integrative Medicine - July 1, 2019 Category: Internal Medicine Source Type: research

Danshensu Ameliorates Cardiac Ischaemia Reperfusion Injury through Activating Sirt1/FoxO1/Rab7 Signal Pathway
AbstractObjective: To explore the specific molecular mechanisms of Danshensu (DSS) in the treatment of ischemia reperfusion injury (IRI).Methods: IRI model was established with isolated rat hearts by performing global ischaemia for 30 min, and then followed by 60 min reperfusion. Also, H9C2 cells were subjected to 4-h hypoxia followed by 3-h reoxygenation. Then 10 μmol/L DSS were added in the reperfusion/reoxygenation step to intervene IRI. Cardiac function, structural change and apoptosis were respectively tested by Langendorff System, hematoxylin and eosin (HE) and terminal-deoxynucleotidyl transferase mediated nick e...
Source: Chinese Journal of Integrative Medicine - June 28, 2019 Category: Internal Medicine Source Type: research

Tongxinluo Ameliorates Myocardial Ischemia-Reperfusion Injury Mainly via Activating Parkin-Mediated Mitophagy and Downregulating Ubiquitin-Proteasome System
AbstractObjectiveTo investigate the protective effects and mechanism of Chinese herbal compound Tongxinluo Capsule ( 通心络胶囊, TXL) on the Parkin-mediated mitophagy and the ubiquitin-proteasome system in a rat model of myocardial ischemia-reperfusion injury (MIRI).MethodsSeventy adult male Sprague-Dawley rats were randomly divided into 7 groups: sham group, MIRI group, low- and high-dose TXL (0.5 and 1 g ·kg-1·d-1, respectively) groups, atorvastatin (ATV) group (7.2 g ·kg-1·d-1), chloroquine (CQ) group (10 g ·kg-1·d-1), and highdose TXL + CQ group. After pharmacological admi...
Source: Chinese Journal of Integrative Medicine - June 21, 2019 Category: Internal Medicine Source Type: research

Effects and Mechanism of Action of Artemisinin on Mitochondria of Plasmodium berghei
AbstractObjectiveTo study the antimalarial effects and mechanisms of artemisinin (Qinghaosu in Chinese, QHS) on mitochondria in mice infected withPlasmodium berghei.MethodsA total of 108 C57 mice infected withPlasmodium berghei were randomly divided into 3 groups by weight: the control group, 200 and 400 mg/kg QHS groups. The two QHS treatment groups were further divided into 4 sub-groups with 12 animals each time according to the treatment time, 0.5, 1, 2, and 4 h. Normal saline was intragastrically (i.g.) administered to the control group. The other two groups received different doses of QHS by i.g. administration. Anima...
Source: Chinese Journal of Integrative Medicine - June 21, 2019 Category: Internal Medicine Source Type: research

Oral Chinese Herbal Medicine for Depressive Disorder in Patients after Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis
Conclusions: In total, CHMs showed potentially beneficial effects on depressive symptoms and post-PCI related clinical symptoms. However, because of small sample size and potential bias of most trials, this result should be interpreted with caution. More rigorous trials with larger sample size and higher quality are warranted to give high quality of evidence to support the use of CHMs for CHD complicated with depression. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - June 20, 2019 Category: Internal Medicine Source Type: research

Effect of Shexiang Baoxin Pill ( 麝香保心丸) in Alleviating Early Hypertensive Renal Injury in Rats
AbstractObjectiveTo investigate the effect of Shexiang Baoxin Pill ( 麝香保心丸, SBP) on early hypertensive renal injury in rats and to explore the possible mechanism.MethodsTwelve-week-old spontaneous hypertensive rats (SHRs) with high-salt diet (dietary containing 8% NaCl) were randomized into the SBP group [40 mg/(kg ·d)], losartan potassium group [20 mg/(kg·d)] and saline group by stratified random sampling method, 12 in each group. Blood pressure and urea albumin creatinine ratio were measured. After 10 weeks, the expression levels of serum creatinine (Scr), hypersensitive C-reactive protein (hs-CRP...
Source: Chinese Journal of Integrative Medicine - June 11, 2019 Category: Internal Medicine Source Type: research

Comparative Studies of Two Major Sets of Tibetan Medical Paintings: A Historical Perspective
AbstractTibetan medicine, one of the time-honored medical systems in the world, has increasingly been receiving attention the world over. Tibetan medical paintings (TMP,tib. Sman thang) has become one of the focal points in the studies of this medical system. To date, there are many atlases and publications on TMP, which are principally based on the two major sets of TMP series existing today in the world, the Lhasa set and the Buryat set. It has been found that the Buryat set is based on the Lhasa set, which was brought in late 19th to the first half of the 20th century from Tibet to Buryatia, Russia. A careful investigat...
Source: Chinese Journal of Integrative Medicine - June 11, 2019 Category: Internal Medicine Source Type: research

Anticancer Effects of Constituents of Herbs Targeting Osteosarcoma
This study aimed to summarize the anticancer effects of constituents of herbs on the progression and metastasis of osteosarcoma cells. It showed that many constituents of herbs inhibited osteosarcoma by targeting proliferation, matrix metalloproteinases, integrin and cadherin, and angiogenesis. The findings might be beneficial for the development of new drugs and treatment strategies. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - June 4, 2019 Category: Internal Medicine Source Type: research

Changes of Intestinal Microecology in Patients with Primary Sjogren ’s Syndrome after Therapy of Yangyin Yiqi Huoxue Recipe (养阴益气活血方)
AbstractObjectiveTo explore the change of intestinal microecology in patients with primary Sjogren ’s syndrome (pSS) and correlation with disease activity, and also discuss the therapy effect of Yangyin Yiqi Huoxue Recipe (养阴益气活血方, YYHD).MethodsSixteen pSS patients were enrolled in the present study, who received 3-month treatment of YYHR, 200 mL orally twice daily. Their pre-and post-test ESSDAI scores, erythrocyte sedimentation rate (ESR) and serum immunoglobulin G (IgG) levels were measured respectively. The 16SrDNA metagenomic sequencing was used to detect and analyze the abundance and diversity of ...
Source: Chinese Journal of Integrative Medicine - June 4, 2019 Category: Internal Medicine Source Type: research

A Formative History of Integrative Medicine in Hong Kong
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - June 1, 2019 Category: Internal Medicine Source Type: research

Xijiao Dihuang Decoction ( 犀角地黄汤) and Rehmannia glutinosa Libosch. protect mice against lipopolysaccharide and tumor necrosis factor alpha-induced acute liver failure
ConclusionsXJDHD inhibits TNF-α-induced apoptosis of hepatocytes by promoting the expression of nuclear factor κ B-regulated anti-apoptotic genes.Rehmannia glutinosa Libosch. is the effective herb of XJDHD and galactose is an active component in this protection. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - June 1, 2019 Category: Internal Medicine Source Type: research

Danqi Tablet ( 丹七片) Regulates Energy Metabolism in Ischemic Heart Rat Model through AMPK/SIRT1-PGC-1α Pathway
AbstractObjectiveTo investigate the cardioprotective effect of Danqi Tablet (DQT, 丹七片) on ischemic heart model rats and the regulative effect on energy metabolism through peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α).MethodsRat ischemic heart model was induced by ligation of left anterior descending coronary artery. Totally 40 Sprague-Dawley rats were randomly divided into sham group, model group, DQT group (1.5 mg/kg daily) and trimetazidine (TMZ) group (6.3 mg/kg daily) according to a random number table, 10 rats in each group. Twenty-eight days after continuous administrati...
Source: Chinese Journal of Integrative Medicine - May 30, 2019 Category: Internal Medicine Source Type: research

Effect of Quercetin on Atherosclerosis Based on Expressions of ABCA1, LXR- α and PCSK9 in ApoE -/- Mice
AbstractObjectiveTo investigate the effect of quercetin on ATP binding cassette transporter A1 (ABCA1), liver X receptor (LXR), and proprotein convertase subtilisin/kexin type 9 (PCSK9) expressions in apoE-knockout (ApoE-/-) mice.MethodsThe high-fat diet-induced atherosclerosis (AS) in ApoE-/- mice was established. Thirty-six mice were divided into 3 groups using random number table method: model group (n=12), quercetin group (n=12), and atorvastatin group (n=12), with C57BL/6J mice of the same strain and age as the control group (n=12). Quercetin group and atorvastatin group were administrated with quercetin and atorvasta...
Source: Chinese Journal of Integrative Medicine - May 30, 2019 Category: Internal Medicine Source Type: research

Anti-obesity Effects of Ginsenosides in High-Fat Diet-Fed Rats
AbstractObjectiveTo examine the anti-obesity effects of ginsenosides in Korea Red Ginseng (KRG,Panax ginseng) in rats fed with a high-fat diet (HFD).MethodsTwenty-five 4-week-old obesity rats after receiving an HFD for 5 weeks; subsequently, they were additionally treated with ginsenosides Rb1, Rd, Rg1, or Re (10 mg/kg, intraperitoneal injection) for a further 3 weeks (n=5 in each group). The control rats were fed a normal diet. The food consumption, body weight, locomotor activity, serum lipids, adipose tissues, nitric oxide (NO) expression, leptin, neuropeptide Y (NPY), cholecystokinin (CCK) in the brains were measured.R...
Source: Chinese Journal of Integrative Medicine - May 30, 2019 Category: Internal Medicine Source Type: research

Topical Delivery of Modified Da-Cheng-Qi Decoction ( 加味大承气汤) Using Low-Frequency Ultrasound Sonophoresis for Refractory Metastatic Malignant Bowel Obstruction: An Open-Label Single-Arm Clinical Trial
ConclusionTopical delivery of MDCQD at 100 g/day using LFUS can improve the treatment response in patients with refractory metastatic MBO. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - May 24, 2019 Category: Internal Medicine Source Type: research

Celastrus orbiculatus Extracts Inhibit Human Hepatocellular Carcinoma Growth by Targeting mTOR Signaling Pathways
AbstractObjectiveTo characterize the molecular mechanism underlying the antineoplastic activity ofCelastrus orbiculatus Thunb. extracts (COE).MethodsThe human hepatocellular carcinoma HepG2 cells with mammalian target of rapamycin (mTOR) knockdown expressed (HepG2/mTOR) were constructed using molecular biological technology.In vitro, the HepG2/mTOR− cells were treated with COE at various concentrations (10, 20, 40, 80, 160 and 320 µ g/mL). Cell viability was determined using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assays. According to the half-maximal inhibitory concentration (IC50)...
Source: Chinese Journal of Integrative Medicine - May 24, 2019 Category: Internal Medicine Source Type: research

Oral Chinese Herbal Medicine for Heart Failure with Preserved Ejection Fraction: A Meta-Analysis
AbstractObjectiveTo evaluate the effectiveness and safety of oral Chinese herbal medicine (OCHM) for heart failure with preserved ejection fraction (HFpEF).MethodsPubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Chinese Biological Medicine Database (CBM), Wanfang Database, Chongqing VIP Information (VIP) and China National Knowledge Infrastructure (CNKI) were searched for appropriate articles from respective inceptions until June 3, 2018. Randomized controlled trials (RCTs) investigating the effectiveness of OCHM for the patients with HFpEF were eligible. Quality assessment was performed by employing the Cochra...
Source: Chinese Journal of Integrative Medicine - May 24, 2019 Category: Internal Medicine Source Type: research

Integrative Medicine Treatment for Severe Stroke —A Case Report
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - May 21, 2019 Category: Internal Medicine Source Type: research

Guizhi Decoction ( 桂枝汤) Inhibits Cholinergic Transdifferentiation by Regulating Imbalance of NGF and LIF in Salt-Sensitive Hypertensive Heart Failure Rats
AbstractObjectiveTo observe the imbalance of anatomical and functional innervation factors of sympathetic nerves, nerve growth factor (NGF) and leukemia inhibitory factor (LIF), in salt-sensitive hypertensive heart failure rats and to explore the effects of treatment with Guizhi Decoction ( 桂枝汤) on sympathetic remodeling by inhibiting cholinergic transdifferentiation.MethodsSS-13BN and Dahl salt-sensitive (DS) rats were divided into 3 groups: SS-13BN group (control group,n=9), DS group (model group,n=9) and GS group (Guizhi Decoction,n=9). After 10 weeks of a high-salt diet, the GS group rats were given Guizhi Decoct...
Source: Chinese Journal of Integrative Medicine - May 20, 2019 Category: Internal Medicine Source Type: research

Effect of Chinese Medicine on No or Slow Reflow after Percutaneous Coronary Intervention in Myocardial Infarction Patients: A Systematic Review and Meta-Analysis
ConclusionsCurrent evidence from RCTs are not sufficient to evaluate the effect of CM adjuvant therapies on no or slow reflow after PCI for MI patients. The included studies are limited by small sample size and unclear baseline conditions. Further rigorously designed researches and verification studies with sufficient number of patients are warranted. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - May 15, 2019 Category: Internal Medicine Source Type: research

Pinellia Total Alkaloids Modulate the GABAergic System in Hippocampal Formation on Pilocarpine-Induced Epileptic Rats
AbstractObjectiveTo investigate the neuromodulatory effect of pinellia total alkaloids (PTA) on the gamma-aminobutyric acidergic (GABAergic) system in epileptic rats, and preliminarily evaluate the anti-epileptic effect of PTA.MethodsNinety-one male Sprague-Dawley rats were randomized to a control group (n=17) or an epileptic group (n=74) using computer-generated random numbers. Status epilepticus (SE) was induced with pilocarpine in the epileptic group. Epileptic rats that survived SE were randomly divided into 4 groups, namely an epilepsy group (n=13), a topiramate (TPM, 60 mg/kg) group (n=12), a high-dose PTA (800 mg/kg...
Source: Chinese Journal of Integrative Medicine - May 15, 2019 Category: Internal Medicine Source Type: research

Mastering Specificity of Acupoints Based on Clinical Verses of Acupuncture and Moxibustion
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - May 15, 2019 Category: Internal Medicine Source Type: research

Effects of Liuwei Dihuang Decoction (Yukmijihwang-tang) on Physical Fatigue by Regulating Neurotransmitters in Brain
Conclusions: YJT could ameliorate fatigue and enhance exercise tolerance through suppressing of brain monoamines including NE, 5-HT, 5-HIAA, and DA in FST mice model. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - May 8, 2019 Category: Internal Medicine Source Type: research

Leonurine: From Gynecologic Medicine to Pleiotropic Agent
AbstractLeonurus japonicus Houtt, a Chinese traditional herbal medicine, has been widely used to cure gynecological diseases, such as incomplete abortion and menoxenia. Leonurine, a major active alkaloid compound only be found inLeonurus japonicus Houtt, has been successfully extracted and purified. Recent evidence has shown that leonurine can regulate a variety of pathologic processes including oxidative stress, inflammation, fibrosis, apoptosis, and multiple metabolic disorders. Here, we have reviewed the pharmacological actions and biological functions of leonurine, with a focus on the role of leonurine in the ameliorat...
Source: Chinese Journal of Integrative Medicine - May 8, 2019 Category: Internal Medicine Source Type: research