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Shenyi Capsule ( 参一胶囊) plus chemotherapy versus chemotherapy for non-small cell lung cancer: A systematic review of overlapping meta-analyses
ConclusionsBased on the best available evidence, treatment effect of SC plus chemotherapy was better than chemotherapy and did not increase side effects. Therefore, SC plus chemotherapy may be superior to chemotherapy for treating NSCLC. However, due to some limitations, SC plus chemotherapy should be cautiously considered, and further high-quality meta-analyses are needed. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 18, 2017 Category: Internal Medicine Source Type: research

Anti-human immunodeficiency virus-1 activities of pratensein and pratensein glycoside from Alhaji maurorum and its parasite Cuscuta kotchiana
ConclusionThe pratensein glycoside inhibits HIV-1 replication in host cells more than pratensein and both extracts are potent inhibitors of HIV-1 entry. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 18, 2017 Category: Internal Medicine Source Type: research

Pattern classification of enterovirus 71-associated hand, foot, and mouth disease in chinese medicine: A retrospective study in 433 cases
ConclusionsLCA on reported symptoms and signs in a retrospective study allowed different subgroups with meaningful clinical correlates to be defifined. These fifindings provide evidence for targeted prevention and treatment interventions. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 17, 2017 Category: Internal Medicine Source Type: research

In silico system pharmacology for the potential bioactive ingredients contained in Xingnaojing Injection ( 醒脑静注射液) and Its material basis for sepsis treatment
ConclusionsThe uncovered mechanism may offer a superior insight for understanding the theory of the Chinese herbal medicine for combating sepsis. Moreover, the potential inhibitors for the sepsis-related targets may provide a good source to find new lead compounds against sepsis disease. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 17, 2017 Category: Internal Medicine Source Type: research

Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups
AbstractObjectiveTo investigate the potential alleviating effects of acupuncture on maternal separation (MS)-induced changes in plasma pro-inflammatory cytokine levels of rat pups.MethodsOn postnatal day 15, rat pups were randomly assigned to 4 groups (n=6 per group) using a random number table: normal, MS, MS with acupuncture stimulation at Shenmen (HT 7) acupoint (MS+HT 7), and MS with acupuncture stimulation at Chengshan (BL 57) acupoint (MS+BL 57) groups. Rat pups in the normal group were housed with their mothers under standard conditions; those in the MS, MS+HT 7 and MS+BL 57 groups were maternally separated and indi...
Source: Chinese Journal of Integrative Medicine - October 6, 2017 Category: Internal Medicine Source Type: research

Review of Anemone raddeana Rhizome and its pharmacological effects
AbstractThe chemical compositions ofAnemone raddeana Rhizome, a kind of traditional Chinese medicine, were reviewed, along with its bioactivity and pharmacological properties and method improvements of extracting and detecting triterpenoid saponins.A. raddeana Rhizome is used to treat neuralgia and rheumatism, and is rich in triterpenoid saponins, most of which are pentacyclic, with oleanane as the nucleus. So far, 37 triterpenoid saponins have been determined from the herb. Its reported bioactivity and pharmacological properties have been described as anticancerous, antimicrobial, anti-inflammatory, analgesic, antipyretic...
Source: Chinese Journal of Integrative Medicine - October 6, 2017 Category: Internal Medicine Source Type: research

Review on antioxidants and evaluation procedures
AbstractAntioxidants are the substances that are capable of counteracting the damaging effects of the physiological process of oxidation occur in animal tissues. These may be nutrients (vitamins and minerals) as well as enzymes (proteins) in our body that assist in chemical reactions. They are believed to play a role in preventing the development of chronic diseases like cancer, diabetes, heart disease, stroke, Alzheimer's disease, rheumatoid arthritis, and cataracts etc. The present review article emphasizes on the various aspects of oxidants and antioxidants viz. definition, types, causes, mechanism, functions, adverse e...
Source: Chinese Journal of Integrative Medicine - October 6, 2017 Category: Internal Medicine Source Type: research

Effects of electroacupuncture on metabolic changes in motor cortex and striatum of 6-hydroxydopamine-induced Parkinsonian rats
ConclusionsEA treatment is able to normalize the metabolic balance in the primary motor cortex and striatum of PD rats, which may contribute to its therapeutic effect on motor deficits. The striatal Glx/Cr ratio may serve as a potential indicator of PD and a therapeutic target of EA treatment. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 6, 2017 Category: Internal Medicine Source Type: research

Analysis of herbal medicine prescriptions for patients in an academic Korean medical hospital: A cross sectional study of electronic medical records (2010 –2013)
ConclusionThis study analysis successfully determined the frequency of a variety of herbal medicines, and many restorative herbal medicines were identified and frequently administered. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 6, 2017 Category: Internal Medicine Source Type: research

Effect of Jiaotai Pill ( 交泰丸) on intestinal damage in partially sleep deprived rats
AbstractObjectiveTo explore the effect and mechanism of Jiaotai Pill ( 交泰丸, JTW) on intestinal mucosal damage in rats with chronic partial sleep deprivation (PSD).MethodsObesity resistant (OR) rats were selected, and underwent 4 h PSD by being exposed to environmental noise for 4 weeks. During the whole PSD period, JTW and estazolam were orally given to the rats respectively in the treating groups. Plasma concentration of lipopolysaccharide (LPS) which is the marker of gut-origin endotoxemia was examined. Intestinal morphology changes were observed by optical microscopy. The protein expression of occludin (Ocln) in t...
Source: Chinese Journal of Integrative Medicine - October 6, 2017 Category: Internal Medicine Source Type: research

Effect of Shen-Fu Injection ( 参附注射液) on hemodynamics in early volume resuscitation treated septic shock patients
ConclusionSFI significantly improved hemodynamic indices such as CI, GEDI, MAP and HR in early volume resuscitation treated septic shock patients. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 6, 2017 Category: Internal Medicine Source Type: research

Recent advances in Chinese medicine for contrast-induced nephropathy
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 6, 2017 Category: Internal Medicine Source Type: research

Effects of compound Zhebei Granule ( 复方浙贝颗粒) combined with doxorubicin on expression of specific surface antigens in mice with transplanted KG-1a cells
AbstractObjectiveTo investigate the effects of Compound Zhebei Granule ( 复方浙贝颗粒, CZG) combined with doxorubicin hydrochloride (adriamycin, ADM) on specific surface antigens in mice with KG-1a transplanted cells.MethodsA subcutaneous tumor xenograft model was established by injection of the acute myeloid leukemia cell line KG-1a into the axillary flanks of BALB/c-nude mice. Twenty-four tumor bearing mice were divided into 4 groups according to a random number table, including normal saline control group, ADM group, high-dose CZG group, and mid-dose CZG group, with 6 mice in each group. Drug administration occurr...
Source: Chinese Journal of Integrative Medicine - October 6, 2017 Category: Internal Medicine Source Type: research

Contrast-induced nephropathy —time for Western medicine and Chinese medicine to team up
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 6, 2017 Category: Internal Medicine Source Type: research

Targeting tumor-associated macrophages by anti-tumor Chinese materia medica
AbstractTumor-associated macrophages (TAMs) play a key role in all stages of tumorigenesis and tumor progression. TAMs secrete different kinds of cytokines, chemokines, and enzymes to affect the progression, metastasis, and resistance to therapy depending on their state of reprogramming. Therapeutic benefit in targeting TAMs suggests that macrophages are attractive targets for cancer treatment. Chinese materia medica (CMM) is an important approach for treating cancer in China and in the Asian region. According to the theory of Chinese medicine (CM) and its practice, some prescriptions of CM regulate the body's internal env...
Source: Chinese Journal of Integrative Medicine - October 1, 2017 Category: Internal Medicine Source Type: research

Chemical composition and pharmacological potential of aromatic water from Salix caprea inflorescence
ConclusionsThe aromatic water's composition and its pharmacological evaluations has been reported in our results for this unique and endemic species. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 29, 2017 Category: Internal Medicine Source Type: research

Chinese and Indian women ’s experience with alternative medications for menopause related symptoms: A qualitative analysis
ConclusionsChinese and Indian women used alternative medicine in prevention and treatment of menopause-related problems even as they were avoiding HRT because of the fear of side effects. They believed that their supplements were effective, safe and cost-beneficial even with long-term use. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 15, 2017 Category: Internal Medicine Source Type: research

Antihypercholesterolemic, antioxidant and renal protective effects of Mengkudu ( Rubiaceae ) fruit in nephropathy-induced albino rats
AbstractObjectiveTo assess the modulatory impact of alcoholic extract of fruit of Mengkudu (AEFM,Morinda citrifolia L., Rubiaceae) on renal oxido-lipidemic stress in hypercholesterolemic albino rats.MethodsTwenty-four male albino rats were randomly divided into four groups with six rats in each group: group I as control, group II fed with hypercholesterolemic diet (HCD) for 45 days (4% cholesterol and 1% cholic acid), Group III rats fed with HCD for 45 days + AEFM (300 mg/kg body weight/day orally) for last 30 days and group IV normal rats fed AEFM alone. The blood was collected using ethylenediamine tetraacetic acid (EDTA...
Source: Chinese Journal of Integrative Medicine - September 15, 2017 Category: Internal Medicine Source Type: research

Dampness-heat accelerates DMBA-induced mammary tumors in rats
AbstractObjectiveTo investigate the impact of dampness-heat (DH) on the development of mammary tumors in 7,12-dimethylbenz(a)anthracene (DMBA)-induced rats.MethodsForty rats were randomly divided into 3 groups in a randomized block design, including the control group (n=13), DMBA group (n=14), and DMBA plus DH group (n=13). Rats in the DMBA group and DMBA plus DH group were intragastrically administrated with DMBA (100 mg/kg) for twice, once per week, while rats in the control group were treated with equivalent volumes of sesame oil. After DMBA administration, rats in the DMBA plus DH group were exposed to a simulated clim...
Source: Chinese Journal of Integrative Medicine - September 15, 2017 Category: Internal Medicine Source Type: research

Salutary potential of ethanolic extract of avocado fruit on anomalous carbohydrate metabolic key enzymes in hepatic and renal tissues of hyperglycaemic albino rats
AbstractObjectiveTo assess the beneficial potential of ethanolic extract of avocado fruit on abnormal carbohydrate metabolic key enzymes in hepatic and renal tissues in streptozotocin (STZ) induced hyperglycemic albino rats.MethodsTwenty-four male albino rats were randomly divided into four groups with six in each group by simple random sampling method. Group 1 as control rats; Group 2 as STZ induced diabetic rats; Group 3 as diabetic rats treated with avocado fruit extract (AFE), 300 mg/kg as aqueous suspension orally for 30 days; Group 4 as diabetic rats treated with gliclazide (5 mg/kg) in aqueous solution orally for 30...
Source: Chinese Journal of Integrative Medicine - September 15, 2017 Category: Internal Medicine Source Type: research

Combination therapy of tacrolimus and Chinese herb medicated bath in children with inverse psoriasis
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 15, 2017 Category: Internal Medicine Source Type: research

Methological quality of systematic reviews and meta-analyses on acupuncture for stroke: A review of review
ConclusionsImportant methodological flaws were found in Chinese systematic reviews and primary studies. It was necessary to improve the methodological quality and reporting quality of both the systematic reviews published in China and primary studies on acupuncture for stroke. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 13, 2017 Category: Internal Medicine Source Type: research

Advantages of Chinese medicine for patients with acquired immunodeficiency syndrome in rural central China
AbstractObjectiveTo analyze the effect of Chinese medicine (CM) on mortality and quality of life (QOL) of acquired immunodeficiency syndrome (AIDS) patients treated with combined antiretroviral therapy (cART).MethodsA random sample of AIDS patients enrolled in the National Chinese Medicine Treatment Trial Program (NCMTP) that met the inclusion criteria was included in this study. NCMTP patients were included as the CM+cART group, and those not in the NCMTP were included as the cART group. Survival from September 2004 to September 2012 was analyzed by retrospective cohort study. QOL was analyzed by cross-sectional study.Res...
Source: Chinese Journal of Integrative Medicine - September 8, 2017 Category: Internal Medicine Source Type: research

Effect of comprehensive therapy based on Chinese medicine patterns on self-efficacy and effectiveness satisfaction in chronic obstructive pulmonary disease patients
AbstractObjectiveTo evaluate the effect of comprehensive therapy based on Chinese medicine (CM) patterns on self-efficacy and satisfaction with its effectiveness in patients with chronic obstructive pulmonary disease (COPD).MethodsA total of 216 patients were randomly divided into the trial group (n =108) and the control group (n =108) based on the stratified and block randomization design. Patients in the trial group were treated with conventional Western medicine combined with Bufei Jianpi Granules ( 补肺健脾颗粒), Bufei Yishen Granules (补肺益肾颗粒), and Yiqi Zishen Granules (益气滋肾颗粒) according t...
Source: Chinese Journal of Integrative Medicine - September 8, 2017 Category: Internal Medicine Source Type: research

Evodiamine inhibits angiotensin II-induced rat cardiomyocyte hypertrophy
AbstractObjectiveTo investigate the effects of evodiamine (Evo), a component ofEvodiaminedia rutaecarpa Juss.) Benth, on cardiomyocyte hypertrophy induced by angiotensin II (Ang II) and further explore the potential mechanisms.MethodsCardiomyocytes from neonatal Sprague Dawley rats were isolated and characterized, and then the cadiomyocyte cultures were randomly divided into control, model (Ang II 0.1 μmol/L), and Evo (0.03, 0.3, 3 μmol/L) groups. The cardiomyocyte surface area, protein level, intracellular free calcium ([Ca2+]i) concentration, activity of nitric oxide synthase (NOS) and content of nitric oxide (NO) ...
Source: Chinese Journal of Integrative Medicine - September 5, 2017 Category: Internal Medicine Source Type: research

Huannao Yicong Decoction ( 还脑益聪方) extract reduces inflammation and cell apoptosis in Aβ 1-42 -induced Alzheimer's disease model of rats
This study was designed to characterize mechanisms by which HYD leads to suppression of inflflammation and apoptosis in the brains of A β1-42-induced rat.MethodsA total of 72 rats were divided into 6 groups, which were referred to as: sham operation group, model group, donepezil-treated group, HYD low-dose group (HYDL), HYD middle-dose group (HYDM) and HYD high-dose group (HYDH). Rats in HYDL, HYDM and HYDH were injected with A β1-42 at the CA1 region of hippocampus to form AD model and were fed the HYD extract at different dose of 3.78, 7.56 and 18.90 g crude drug/kg. The behavioral changes of rats were evaluate...
Source: Chinese Journal of Integrative Medicine - September 1, 2017 Category: Internal Medicine Source Type: research

Insights of Chinese medicine on ventricular remodeling: Multiple-targets, individualized-treatment
This article reviews the published studies on the mechanisms and therapeutic applications of CM in VR. The major aspects include: mechanistic studies of VR, molecular biology and myocardial functional studies of CM therapies on VR, and mechanism of CM therapies on VR. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 1, 2017 Category: Internal Medicine Source Type: research

Therapeutic benefits of natural ingredients for atopic dermatitis
AbstractAlthough a variety of regimens are available for the treatment of atopic dermatitis (AD), severe adverse reactions and unpopular costs often limit their usage. In contrast, certain inexpensive, naturally-occurring ingredients are proven effective for AD with fewer side effects. The benefificial effects of these ingredients can be attributed to inhibition of cytokine and chemokine expression, IgE production, inflammatory cell infiltration, histamine release, and/or the enhancement of epidermal permeability barrier function. Since herbal medicines are widely available, inexpensive and generally safe, they could be va...
Source: Chinese Journal of Integrative Medicine - September 1, 2017 Category: Internal Medicine Source Type: research

Effect of Qingfei Mixture ( 清肺合剂) on pediatric mycoplasma pneumoniae pneumonia with phlegm heat obstructing Fei (Lung) syndrome
AbstractObjectiveTo explore the effect and mechanism of Qingfei Mixture ( 清肺合剂), a Chinese medicine, in treating mycoplasma pneumonia (MP) in MP patients and rat modelMethodsA total of 46 MP children with phlegm heat obstructing Fei (Lung) syndrome were randomly assigned to two groups by the method of random number table, with 23 children in each group. The control group was treated with intravenous infusion of azithromycin; the treatment group received intravenous infusion of azithromycin and oral administration of Qingfei Mixture. The treatment course was 7 days. Major symptoms and minor symptoms were observed an...
Source: Chinese Journal of Integrative Medicine - September 1, 2017 Category: Internal Medicine Source Type: research

Combination of quercetin, cinnamaldehyde and hirudin protects rat dorsal root ganglion neurons against high glucose-induced injury through Nrf-2/HO-1 activation and NF- κB inhibition
AbstractObjectiveTo examine the effects of the combination of quercetin (Q), cinnamaldehyde (C) and hirudin (H), a Chinese medicine formula on high glucose (HG)-induced apoptosis of cultured dorsal root ganglion (DRG) neurons.MethodsDRG neurons exposed to HG (45 mmol/L) for 24 h were employed as anin vitro model of diabetic neuropathy. Cell viability, reactive oxygen species (ROS) level and apoptosis were determined. The expression of nuclear factor of Kappa B (NF- κB), inhibitory kappa Bα(IκBα), phosphorylated IκBα and Nf-E2 related factor 2 (Nrf2) were examined using reverse transcript...
Source: Chinese Journal of Integrative Medicine - September 1, 2017 Category: Internal Medicine Source Type: research

Electro-acupuncture treatment for internet addiction: Evidence of normalization of impulse control disorder in adolescents
AbstractObjectiveTo observe the impacts of electro-acupuncture (EA) and psychological intervention (PI) on impulsive behavior among internet addiction (IA) adolescents.MethodsThirty-two IA adolescents were allocated to either EA (16 cases) or PI (16 cases) group by a randomized digital table. Subjects in the EA group received EA treatment and subjects in the PI group received cognition and behavior therapy. All adolescents underwent 45-d intervention. Sixteen healthy volunteers were recruited into a control group. Barratt Impulsiveness Scale (BIS-11) scores, Young's Internet Addiction Test (IAT) as well as the ratio of bra...
Source: Chinese Journal of Integrative Medicine - September 1, 2017 Category: Internal Medicine Source Type: research

Rutaecarpine inhibits intimal hyperplasia in a balloon-injured rat artery model
AbstractObjectiveTo investigate the effect and potential mechanisms of rutaecarpine (Rut) in a rat artery balloon-injury model.MethodsThe intimal hyperplasia model was established by rubbing the endothelia with a balloon catheter in the common carotid artery (CCA) of rats. Fifty rats were randomly divided into fifive groups, ie. sham, model, Rut (25, 50 and 75 mg/kg) with 10 rats of each group. The rats were treated with or without Rut (25, 50, 75 mg/kg) by intragastric administration for 14 consecutive days following injury. The morphological changes of the intima were evaluated by hematoxylin-eosin staining. The expressi...
Source: Chinese Journal of Integrative Medicine - September 1, 2017 Category: Internal Medicine Source Type: research

Red yeast rice prevents atherosclerosis through regulating inflammatory signaling pathways
AbstractObjectiveTo observe the effects of red yeast rice (RYR) on blood lipid levels, aortic atherosclerosis (AS), and plaque stability in apolipoprotein E gene knockout (ApoE-/-) mice.MethodsTwenty-four ApoE-/- mice were fed with a high-fat diet starting from 6 weeks of age. Mice were randomized into three groups (n = 8 in each group): model group (ApoE-/- group), RYR group (ApoE-/- + RYR group), and simvastatin group (ApoE-/- + simvastatin group). Eight 6-week-old C57BL/6 mice were assigned as the control group and fed with a basic diet. After 36 weeks, plasma lipids and inflflammatory factors were measured. Aortic athe...
Source: Chinese Journal of Integrative Medicine - September 1, 2017 Category: Internal Medicine Source Type: research

Recurrent coronary restenosis treated with Chinese medicine: A case report
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 1, 2017 Category: Internal Medicine Source Type: research

Efficacy and safety of Quxie Capsule ( 祛邪胶囊) in metastatic colorectal cancer: A double-blind, randomized, placebo controlled trial
ConclusionsQuxie Capsule showed good safety and efficacy, and could prolong the OS of patients with mCRC. (Registration No. ChiCTR-IOR-16009733) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 24, 2017 Category: Internal Medicine Source Type: research

Analysis on composition rules of Chinese patent drugs treating pain-related diseases based on data mining method
ConclusionsThe composition rules of the oral prescriptions for treating headache, stomachache and dysmenorrhea recorded in NSCPD has been summarized. Although there were similarities between them, formula varied according to different locations of pain. It can serve as an evidence and reference for clinical treatment and new drug development. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 24, 2017 Category: Internal Medicine Source Type: research

Qingkailing Injection ( 清开灵注射液) for treatment of children pneumonia induced by respiratory syncytial virus: A meta-analysis of randomized controlled trials
AbstractObjectiveTo evaluate the efficacy and safety of Qingkailing Injection ( 清开灵注射液, QKL) for treatment of children pneumonia caused by respiratory syncytial virus (RSV).MethodsRandomized clinical trials (RCTs) comparing QKL with ribavirin injection in the treatment of children pneumonia induced by RSV were searched in PubMed, Science Direct, Cochrane Library, Chinese VIP database, CNKI and Wanfang databases from their inception to March 2014. Meta-analyses were performed using RevMan 5.2 software. The methodological quality of the selected RCTs was evaluated by the Modified Jadad Score. The primary outcome ...
Source: Chinese Journal of Integrative Medicine - August 17, 2017 Category: Internal Medicine Source Type: research

Tongxinluo Capsule ( 通心络胶囊) for cardiac syndrome X: A systematic review and meta-analysis
AbstractObjectiveTo evaluate the efficacy and safety of Tongxinluo Capsule ( 通心络胶囊, TXL) for patients with cardiac syndrome X (CSX).MethodsRandomized controlled trials (RCTs) regarding TXL in the treatment of CSX were searched in Chinese Biomedicine Literature Database, China National Knowledge Infrastructure, Chinese Scientific Journal Database, Wanfang Database, PubMed, EMBASE, Cochrane Central Register of Controlled Trial, websites of the Chinese and International Clinical Trial Registry platform up to June 30, 2015. The intervention was either TXL alone or TXL combined with conventional treatment, while the c...
Source: Chinese Journal of Integrative Medicine - August 17, 2017 Category: Internal Medicine Source Type: research

Curcuma wenyujin Y. H. Chen et C. Ling n-Butyl alcohol extract inhibits AGS cell Helicobacter pylori CagA+VacA+ promoted invasiveness by down-regulating caudal type homeobox transcription factor and claudin-2 expression
AbstractObjectiveTo investigate the effects and possible mechanisms of action ofCurcuma wenyujin Y. H. Chen et C. Ling n-Butyl alcohol extract (CWNAE) on repression of human gastric cancer (GC) AGS cell invasion induced by co-culturing withHelicobacter pylori (HP).MethodsAGS cells were cultured with HP of positive or negative cytotoxin-associated gene A (CagA) and vacuolating cytotoxin gene A (VacA) expression (CagA+/- or VacA+/-) and divided into 5 group. Group A was cultured without HP as a control, Group B with HPCagA+VacA+, Group C with HPCagA-VacA-, Group D with HPCagA+VacA+ and CWNAE, and Group E with HPCagA-VacA- an...
Source: Chinese Journal of Integrative Medicine - August 17, 2017 Category: Internal Medicine Source Type: research

Impact of Jumihaidokuto (Shi-Wei-Bai-Du-Tang) on treatment of chronic spontaneous urticaria: A randomized controlled study
AbstractObjectiveTo study the effect of Jumihaidokuto (Shi-Wei-Bai-Du-Tang, 十味败毒汤) in the management of chronic spontaneous urticaria.MethodsA randomized two-arm, parallel group study was conducted to compare the effect of Jumihaidokuto (6 g daily) with a control for 8 weeks. Concomitant therapy (e.g., antihistamines) was continued. Twenty-one subjects with severe chronic urticaria were enrolled in this study. The primary treatment outcome was the severity score proposed by the Japanese Dermatological Association. Secondary outcomes were quality of life (Skindex-16), itch intensity (Visual Analogue Scale), and pa...
Source: Chinese Journal of Integrative Medicine - August 17, 2017 Category: Internal Medicine Source Type: research

Preliminary research on syndrome types of Chinese medicine in children with primary nephrotic syndrome
AbstractObjectiveTo provide an objective reference for the syndrome types of Chinese medicine (CM) associated with pediatric primary nephrotic syndrome (PNS).MethodsA cross-sectional study was performed. Data on clinical symptoms, CM syndrome types, biochemical indices, and medications used were collected from 98 children with PNS. Then, the correlation between CM syndromes and biochemical indices, as well as medications used, was analyzed.ResultsThe four most common symptoms in children with PNS were brown urine, red tongue, excessive sweating, and swelling of the face and limbs. The syndromes of qi deficiency of Fei (Lun...
Source: Chinese Journal of Integrative Medicine - August 17, 2017 Category: Internal Medicine Source Type: research

Anti-nociceptive effect of patchouli alcohol: Involving attenuation of cyclooxygenase 2 and modulation of mu-opioid receptor
AbstractObjectiveTo explore the anti-nociceptive effect of patchouli alcohol (PA), the essential oil isolated fromPogostemon cablin (Blanco) Bent, and determine the mechanism in molecular levels.MethodsThe acetic acid-induced writhing test and formalin-induced plantar injection test in mice were employed to confifirm the effectin vivo. Intracellular calcium ion was imaged to verify PA on mu-opioid receptor (MOR). Cyclooxygenase 2 (COX2) and MOR of mouse brain were expressed for determination of PA ’s target. Cellular experiments were carried out to find out COX2 and MOR expression induced by PA.ResultsPA significantl...
Source: Chinese Journal of Integrative Medicine - August 9, 2017 Category: Internal Medicine Source Type: research

Brucine suppresses breast cancer metastasis via inhibiting epithelial mesenchymal transition and matrix metalloproteinases expressions
AbstractObjectiveTo examine the effect of brucine on the migration, invasion, adhesion and expressions of epithelial-to-mesenchymal transition (EMT) markers and matrix metalloproteinases (MMPs) in the highly metastatic breast cancer cell lines MDA-MB-231 and Hs578-T.MethodsMDA-MB-231 and Hs578-T cells were divided to 4 groups: the control group (0.1% DMSO), and 25, 50 and 100 μmol/L brucine groups. The cell viability was determined using a CellTiter-Glo® luminescent cell viability. The scratch wound healing assay and tanswell migration assay were used to determine the migration ability of these cells treated by diff...
Source: Chinese Journal of Integrative Medicine - August 9, 2017 Category: Internal Medicine Source Type: research

Gefitinib plus Fuzheng Kang ’ai Formula (扶正抗癌方) in patients with advanced non-small cell lung cancer with epidermal growth factor receptor mutation: A randomized controlled trial
ConclusionPatients with advanced non-small cell lung cancer selected by EGFR mutations have longer PFS, MST and with less toxicity if they are treated with gefifitinib plus FZKA than gefifitinib alone. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 9, 2017 Category: Internal Medicine Source Type: research

Allicin improves cardiac function by protecting against apoptosis in rat model of myocardial infarction
AbstractObjectiveTo study the effects of allicin on cardiac function and underlying mechanism in rat model of myocardial infarction (MI).MethodsNinety-four Wistar rats were randomly assigned to 6 groups (n=14 –16 per group): sham control group [underwent thoracotomy without left anterior descending (LAD) occlusion and only received an injection of the same amount of citrate buffer], MI control group (subjected to LAD occlusion and only received an injection of same amount of citrate buffer), positive c ontrol group (subjected to LAD occlusion and received an injection of diltiazem hydrochloride at the dose of 1.5 mg/...
Source: Chinese Journal of Integrative Medicine - July 31, 2017 Category: Internal Medicine Source Type: research

Traditional Chinese medicine for modern treatment of Parkinson ’s disease
AbstractParkinson ’s disease (PD) is a chronic and progressive degenerative disorder of brain commonly seen among the elderly. As conventionally medical therapy is of limited relief and potential side effects, complementary and alternative medicine (CAM) has attracted growing public and professional attention. Ther apies such as acupuncture, musical/rhythmic therapy and deep brain stimulation have been gradually proved positively in clinic. In this review, we retrospected the scientifific or evidence-based-medicine advances of application and research for modern treatment of PD by CAM, especially traditional C hinese...
Source: Chinese Journal of Integrative Medicine - July 31, 2017 Category: Internal Medicine Source Type: research

Ethnic Chinese medicine, borderless civilization — On the identity of humane and scientific nature of Chinese and Western medicines
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 31, 2017 Category: Internal Medicine Source Type: research

Electro-acupuncture at Governor Vessel improves neurological function in rats with spinal cord injury
AbstractObjectiveTo determine the effects of electro-acupuncture (EA) at Governor Vessel (GV) on the locomotor function in spinal cord injury (SCI) rats and explore the underlying mechanism.MethodsThirtytwo male Sprague-Dawley rats were randomly divided into four groups namely: the sham group (with sham operation); the untreated group (without treatment after spinal cord impact); the EA-1 group [EA applied at Baihui (GV 20) and Fengfu (GV 16) after spinal cord impact] and the EA-2 group [with EA applied at Dazhui (GV 14) and Mingmen (GV 4) after spinal cord impact]. Real-time quantitative-polymerase chain reaction (RT-PCR)...
Source: Chinese Journal of Integrative Medicine - July 31, 2017 Category: Internal Medicine Source Type: research

Schizandra chinensis exhibits phytoestrogenic effects by regulating the activation of estrogen receptor- α and -β
AbstractObjectiveTo investigate the phytoestrogenic effects ofSchizandra chinensis (SC) extract by regulating the activation of estrogen receptor.MethodsWestern blotting assay was performed to investigate the effect of SC extract (1, 10, 100 μg/mL) on the expression of estrogen receptor (ER)-α and -β in MCF-7 human breast cancer cells. Cell viability and the levels of c-fos and c-Jun were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and Western blot analysis, respectively, to further confirm th e anti-cancer effect of SC extract.ResultsSC extract increased the expressio...
Source: Chinese Journal of Integrative Medicine - July 31, 2017 Category: Internal Medicine Source Type: research

Weaker cognitive control abilities of Pi (Spleen) qi-deficient individuals supported Chinese medicine diagnosis
AbstractObjectiveTo investigate whether Pi (Spleen) qi-deficiency affected psychological and neural responses in relevance to cognitive control.MethodsPi qi-deficient and balanced participants were asked to perform the Stroop task, a classical cognitive control paradigm. In this paradigm, participants had to judge the color of the prompted word. The word ’s meaning indicated the color (the consistent condition) or not (the inconsistent condition), or were unrelated to the color (the neutral condition). Electroencephalograph (EEG) was recorded during the task.ResultsEvent-related potential (ERP) results showed that Pi...
Source: Chinese Journal of Integrative Medicine - July 28, 2017 Category: Internal Medicine Source Type: research