Enhancement of Swimming Endurance by Herbal Supplement M3P
AbstractObjectiveTo investigate the effect of M3P (containingDeer antler, Cordyceps sinensis, Rhodiola rosea, andPanax ginseng); an herbal remedy with the function of tonifying Kidney (Shen) and invigorating Spleen (Pi), replenishing qi and nourishing blood; on fatigue alleviation, endurance capacity and toxicity.MethodsSwimming with weight-loading of 24 male ICR mice was used to evaluate the endurance capacity, and fatigue-related plasma biomarkers were determined. Mice were randomly assigned to control or M3P treatment groups with 6 mice for each group and were orally administered with M3P everyday for 8 weeks at doses 0...
Source: Chinese Journal of Integrative Medicine - January 20, 2022 Category: Internal Medicine Source Type: research

Effect of Wrist-Ankle Acupuncture on Postoperative Analgesia after Total Knee Arthroplasty
AbstractObjectiveTo evaluate the effect of wrist-ankle acupuncture (WAA) in pain and functional recovery after total knee arthroplasty (TKA).MethodsFrom June to September 2020, 94 participants were included from the Second Hospital of Tangshan and randomly assigned to the WAA group (47 cases) and the sham WAA group (47 cases) by a random number table, receiving real or sham WAA treatment, respectively. The primary outcome measure involved the visual analogue scale (VAS) scores at rest and in motion. The secondary outcomes involved the range of motion (ROM) of the knee joints, straight-leg raising time, postoperative weight...
Source: Chinese Journal of Integrative Medicine - January 19, 2022 Category: Internal Medicine Source Type: research

Efficacy and Safety of Mulberry Twig Alkaloids Tablet for Treatment of Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Study
AbstractObjectiveTo assess the efficacy and safety of mulberry twig alkaloids (Sangzhi alkaloids, SZ-A) for treatment of type 2 diabetes in a randomized, double-blind, placebo-controlled multicenter clinical trial.MethodsA total of 200 patients were randomized to receive SZ-A (n=100) or placebo (n=100) for 16 weeks. The data analysis system for electronic data capture clinical trial central randomization system was used for randomization and dispensing of drugs. The primary outcome was the change in glycosylated hemoglobin (HbA1c) level. The secondary outcome included the proportions of cases with HbA1c
Source: Chinese Journal of Integrative Medicine - January 19, 2022 Category: Internal Medicine Source Type: research

Correlation between Characteristics of Coronary Plaque and Chinese Medicine Syndromes of Coronary Heart Disease: A Cross-Sectional Study Analysed by Intravascular Ultrasound
AbstractObjectiveTo analyse the correlation between the characteristics of coronary plaque in coronary heart disease (CHD) patients with phlegm-blood stasis syndrome (PBS) and blood stasis syndrome (BSS).MethodsPatients were divided into different groups based on Chinese medicine (CM) syndrome differentiation. The baseline demographics and clinical variables were collected from the medical records. Additionally, the characteristics of plaque and pathological manifestations in coronary artery were evaluated using intravascular ultrasound (IVUS).ResultsA total of 213 CHD patients were enrolled in two groups: 184 were diagnos...
Source: Chinese Journal of Integrative Medicine - January 19, 2022 Category: Internal Medicine Source Type: research

Andrographolide Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer Cells by Interfering with NF- κB and PI3K/AKT Signaling In Vitro and In Vivo
ConclusionsAndrographolide inhibits proliferation and promotes apoptosis in bladder cancer cells by interfering with NF- κB and PI3K/AKT signalingin vitro andin vivo. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 19, 2022 Category: Internal Medicine Source Type: research

Medication Rule Analysis of the Diagnosis and Treatment Programs of Chinese Medicine for the Prevention and Treatment of COVID-19 in China
ConclusionsCM for COVID-19 prevention mainly focuses on improving human immunity; for treatment, prescription focuses on clearing the lungs and removing dampness. Prescriptions vary with regions, perhaps due to climatic and environmental differences, which help clinicians to quickly make CM plans and treat patients according to clinical status, further minimizing resource wastage. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 13, 2022 Category: Internal Medicine Source Type: research

New Proposals for Application of Terahertz Imaging Technique in Chinese Medicine
AbstractThe rapid development of terahertz technology promotes the realization of various terahertz imaging systems. Terahertz technology features terahertz waves as good non-invasive illumination sources due to their high spectral resolution, penetration and safety. The terahertz imaging technique (TIT) has gradually been extended from the biomedical field to the field of Chinese medicine (CM), and it has become a powerful tool for seeking scientific evidence for CM theories with the use of modern science and technology. This paper reviews the current application of TITs in the field of CM research, and most importantly o...
Source: Chinese Journal of Integrative Medicine - January 13, 2022 Category: Internal Medicine Source Type: research

A Network Pharmacology-Based Study on Antidepressant Effect of Salicornia europaea L. Extract with Experimental Support in Chronic Unpredictable Mild Stress Model Mice
AbstractObjectiveTo investigate the pharmacodynamic material basis, mechanism of actions and targeted diseases ofSalicornia europaea L. (SE) based on the network pharmacology method, and to verify the antidepressant-like effect of the SE extract by pharmacological experiments.MethodsRetrieval tools including Chinese medicine (CM), PubMed, PharmMapper, MAS 3.0 and Cytoscape were used to search the components of SE, predict its targets and related therapeutic diseases, and construct the “Component-Target-Pathway” network of SE for central nervous system (CNS) diseases. Further, protein-protein interaction (PPI) n...
Source: Chinese Journal of Integrative Medicine - January 13, 2022 Category: Internal Medicine Source Type: research

Protective Effect of Shenfu Injection ( 参附注射液) on Vascular Endothelial Damage in a Porcine Model of Hemorrhagic Shock
AbstractObjectiveTo investigate the effects of Shenfu Injection ( 参附注射液, SFI) on endothelial damage in a porcine model of hemorrhagic shock (HS).MethodsAfter being bled to a mean arterial pressure of 40 ±3 mm Hg and held for 60 min, 32 pigs were treated with a venous injection of either shed blood (transfusion group), shed blood and saline (saline group), shed blood and SFI (SFI group) or without resuscitation (sham group). Venous blood samples were collected and analyzed at baseline and 0, 1, 2, 4, and 6 h after HS. Tumor necrosis factor-α (TNF-α), serum interleuking (IL)-6, and IL-10 levels w...
Source: Chinese Journal of Integrative Medicine - January 13, 2022 Category: Internal Medicine Source Type: research

Treatment Progress in Diminished Ovarian Reserve: Western and Chinese Medicine
AbstractDiminished ovarian reserve (DOR), generally defined as a decreased number or quality of oocytes, has a significant impact on quality of life and fertility in women. In recent years, the incidence of DOR has been increasing and the ages of patients are younger. The search for an effective DOR treatment has emerged as one of the preeminent research topics in reproductive health. An effective DOR therapy would improve ovarian function, fertility, and quality of life in patients. In this review we evaluated DOR treatment progress both in Western medicine and Chinese medicine, and elucidated the characteristics of each ...
Source: Chinese Journal of Integrative Medicine - January 11, 2022 Category: Internal Medicine Source Type: research

Schisandrin B Inhibits NLRP3 Inflammasome Pathway and Attenuates Early Brain Injury in Rats of Subarachnoid Hemorrhage
AbstractObjectiveTo determine whether Schisandrin B (Sch B) attenuates early brain injury (EBI) in rats with subarachnoid hemorrhage (SAH).MethodsSprague-Dawley rats were divided into sham (sham operation), SAH, SAH+vehicle, and SAH+Sch B groups using a random number table. Rats underwent SAH by endovascular perforation and received Sch B (100 mg/kg) or normal saline after 2 and 12 h of SAH. SAH grading, neurological scores, brain water content, Evan ’s blue extravasation, and terminal transferase-mediated dUTP nick end-labeling (TUNEL) staining were carried out 24 h after SAH. Immunofluorescent staining was performe...
Source: Chinese Journal of Integrative Medicine - January 11, 2022 Category: Internal Medicine Source Type: research

Glycyrrhizin-Induced Pseudohyperaldosteronism: A Case Report
In conclusion, this case should remind clinicians of the potential dangers of glycyrrhizin (high blood pressure, low blood potassium and abnormal changes in ECG, among other effects). The timely detection and effective treatment of glycyrrhizin-induced PsHA can prevent the occurrence of serious complications. The importance of taking a detailed medical history is also emphasized. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 11, 2022 Category: Internal Medicine Source Type: research

Severe Type of COVID-19: Pathogenesis, Warning Indicators and Treatment
AbstractCoronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, is a major public health issue. The epidemic is unlikely to be contained until the global launch of safe and effective vaccines that could prevent serious illnesses and provide herd immunity. Although most patients have mild flu-like symptoms, some develop severe illnesses accompanied by multiple organ dysfunction. The identification of pathophysiology and early warning biomarkers of a severe type of COVID-19 contribute to the treatment and prevention of serious complications. Here, we review the pathophysiology, early w...
Source: Chinese Journal of Integrative Medicine - December 29, 2021 Category: Internal Medicine Source Type: research

Application and Prospect of Platelet Multi-Omics Technology in Study of Blood Stasis Syndrome
AbstractThe abnormality of platelet function plays an important role in the pathogenesis and evolution of blood stasis syndrome (BSS). The explanation of its mechanism is a key scientific issue in the study of cardiovascular and cerebrovascular diseases and treatment. System biology technology provides a good technical platform for further development of platelet multi-omics, which is conducive to the scientific interpretation of the biological mechanism of BSS. The article summarized the pathogenesis of platelets in BSS, the mechanism of action of blood activating and stasis resolving drugs, and the application of genomic...
Source: Chinese Journal of Integrative Medicine - December 20, 2021 Category: Internal Medicine Source Type: research

Current Status and Research Trends of Panax Between 1900 –2019: A Bibliometric Analysis
ConclusionThis research provides a reference for further research of the genus and individual species. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 18, 2021 Category: Internal Medicine Source Type: research

Anti-obesity and Gut Microbiota Modulation Effect of Astragalus Polysaccharides Combined with Berberine on High-Fat Diet-Fed Obese Mice
AbstractObjectiveTo investigate whether astragalus polysaccharides (APS) combined with berberine (BBR) can reduce high-fat diet (HFD)-induced obesity in mice.MethodsExcept for normal mice, 32 HFD-induced obese mice were randomized into HFD, APS (1,000 mg/kg APS), BBR (200 mg/kg BBR), and APS plus BBR (1,000 mg/kg APS plus 200 mg/kg BBR) groups, respectively. After 6-week treatment (once daily by gavage), the obesity phenotype and pharmacodynamic effects were evaluated by histopathological examination of epididymal fat, liver, and colon using hematoxylin-eosin staining and serum biochemical analyses by an automated chemistr...
Source: Chinese Journal of Integrative Medicine - December 18, 2021 Category: Internal Medicine Source Type: research

Knowledge Domain and Emerging Trends of Chinese Medicine in Management of Pediatric Asthma: A Scientometric Study
ConclusionsCM research in the management of pediatric asthma will maintain the current trend of steady growth. This scientometric analysis may help scientists to identify the areas of interests and future directions in the field. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 18, 2021 Category: Internal Medicine Source Type: research

Beneficial Effects and Potential Mechanisms of Tai Chi on Lower Limb Osteoarthritis: A Biopsychosocial Perspective
AbstractLower limb osteoarthritis (OA) is a chronic, multifactorial disease characterized by impaired physical function, chronic pain, compromised psychological health and decreased social functioning. Chronic inflammation plays a critical role in the pathophysiology of OA. Tai Chi is a type of classical mind-body exercise derived from ancient Chinese martial arts. Evidence supports that Tai Chi has significant benefits for relieving lower limb OA symptoms. Using a biopsychosocial framework, this review aims to elucidate the beneficial effects of Tai Chi in lower limb OA and disentangle its potential mechanisms from the pe...
Source: Chinese Journal of Integrative Medicine - December 18, 2021 Category: Internal Medicine Source Type: research

Effects of Interactive Dynamic Scalp Acupuncture on Motor Function and Gait of Lower Limbs after Stroke: A Multicenter, Randomized, Controlled Clinical Trial
AbstractObjectiveTo evaluate the effects of interactive dynamic scalp acupuncture (IDSA), simple combination therapy (SCT), and traditional scalp acupuncture (TSA) on motor function and gait of the lower limbs in post-stroke hemiplegia patients.MethodsA total of 231 patients with post-stroke hemiplegia was randomly divided into IDSA (78 cases), SCT (78 cases), and TSA (75 cases) groups by a random number table. Scalp acupuncture (SA) and lower-limb robot training (LLRT) were both performed in the IDSA and SCT groups. The patients in the TSA group underwent SA and did not receive LLRT. The treatment was administered once da...
Source: Chinese Journal of Integrative Medicine - December 15, 2021 Category: Internal Medicine Source Type: research

Electroacupuncture Attenuates Immune-Inflammatory Response in Hippocampus of Rats with Vascular Dementia by Inhibiting TLR4/MyD88 Signaling Pathway
AbstractObjectiveTo investigate whether electroacupuncture (EA) alleviates cognitive impairment by suppressing the toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) signaling pathway, which triggers immune-inflammatory responses in the hippocampus of rats with vascular dementia (VaD).MethodsThe experiments were conducted in 3 parts and in total the Sprague-Dawley rats were randomly divided into 8 groups by a random number table, including sham, four-vessel occlusion (4-VO), 4-VO+EA, 4-VO+non-EA, sham+EA, 4-VO+lipopolysaccharide (LPS), 4-VO+LPS+EA, and 4-VO+TAK-242 groups. The VaD model was established b...
Source: Chinese Journal of Integrative Medicine - December 15, 2021 Category: Internal Medicine Source Type: research

Effect of Jiuwei Zhuhuang Powder on Cough Resolution in Children with Upper Respiratory Tract Infections: A Multicenter Randomized Controlled Trial
ConclusionJWZH seemed to be a safe and effective therapy for URTI-associated cough in children. (Trial registration No. ChiCTR2000039421) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 15, 2021 Category: Internal Medicine Source Type: research

Jug-PLGA-NPs, a New Form of Juglone with Enhanced Efficiency and Reduced Toxicity on Melanoma
AbstractObjectiveTo verrify the anti-tumor efficacy and toxicity between juglone (Jug) and Jug-loaded PLGA nanoparticles (Jug-PLGA-NPs).MethodsJug-PLGA-NPs were prepared by ultrasonic emulsification. The anti-tumor activity of Jug (2, 3, 4 µg/mL) and Jug-PLGA-NPs (Jug: 2, 3, 4 µg/mL)in vitro was measured by MTT assay and cell apoptosis analysis. The distribution, anti-tumor effect and biological safetyin vivo was evaluated on A375 nude mice.ResultsWith the advantage of good penetration and targeting properties, Jug-PLGA-NPs significantly inhibited proliferation and migration of melanoma cells bothin vitro andin vivo (P
Source: Chinese Journal of Integrative Medicine - December 15, 2021 Category: Internal Medicine Source Type: research

In Silico Screening of Natural Products as Potential Inhibitors of SARS-CoV-2 Using Molecular Docking Simulation
ConclusionNatural products or their derivatives may be one of the potential targets to fight against SARS-CoV-2. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 15, 2021 Category: Internal Medicine Source Type: research

Pharmacodynamic Mechanism of Kuanxiong Aerosol for Vasodilation and Improvement of Myocardial Ischemia
ConclusionKXA may inhibit influx and release of calcium and activate the CaMK II/ERK signaling pathway to produce vasodilatory effects, thereby improving myocardial injury. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 12, 2021 Category: Internal Medicine Source Type: research

Effects of Qingre Huoxue Jiedu Formula on Nerve Growth Factor-Induced Psoriasis
AbstractObjectiveTo elucidate the mechanisms of 4 effective components from a Chinese medicine formula, namely Qingre Huoxue Jiedu Formula (QHJ heat- and toxin-clearing and blood-activating formula), in the treatment of nerve growth factor (NGF)-induced psoriasis.MethodsKeratinocyte proliferation and T cell proliferation models were developed using NGF. An NGF solution (NGF+DMEM, 100 ng/mL) was added to all induced groups and treated groups and were cultured for 24 h, while a solution with NTRK1 antagonist (K252a+DEME, 300 nmol/L) was added and cultured for 1 h. The models were used to evaluate the effects of the treatment...
Source: Chinese Journal of Integrative Medicine - December 12, 2021 Category: Internal Medicine Source Type: research

Treatment of Psoriasis Vulgaris with Medicated Thread Moxibustion of Zhuang Medicine: A Multicenter Randomized, Parallel Controlled Trial
AbstractObjectiveTo explore the efficacy and safety of Zhuang medicine medicated thread moxibustion (ZMTM) on psoriasis vulgaris.MethodsA multicenter, randomized, parallel controlled clinical trial was designed. A total of 241 outpatients with psoriasis vulgaris were randomly divided into a control group (120 cases) and a treatment group (121 cases) using a central block randomization from June 2015 to May 2018. The control group was treated with Western medicines alone including pidotimod dispersible tablets, vitamin B compound tablets, and compound cod liver oil-zinc oxide ointment. The treatment group was treated with Z...
Source: Chinese Journal of Integrative Medicine - December 12, 2021 Category: Internal Medicine Source Type: research

Effect of Acupuncture on Outcomes of In Vitro Fertilisation: A Scoping Review
ConclusionsAvailable evidence suggests that acupuncture therapy could improve clinical pregnancy rates. However, whether acupuncture could increase live birth events was difficult to determine based on the few studies that have reported this outcome indicator. Furthermore, the methodological quality of most systematic reviews was assessed as critically low or low. Studies with a rigorous design and standardized implementation should be performed to refine the available evidence. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 12, 2021 Category: Internal Medicine Source Type: research

Effect of Electro-acupuncture on Vasomotor Symptoms in Rats with Acute Cerebral Infarction Based on Phosphatidylinositol System
AbstractObjectiveTo investigate the effect of electro-acupuncture (EA) on vasomotor symptoms in rats with acute cerebral infarction, by observing the changes in the expression of factors related to the phosphatidylinositol (PI) system.MethodsForty-two Wistar rats were randomly divided into 3 groups by a random number table: the control group (n=6), the model group (n=18) and the EA group (n=18). The EA group was given EA treatment at Shuigou (GV 26) instantly after modeling with middle cerebral artery occlusion (MCAO) method, while the model and control groups were not given any treatment. The degrees of neurological defic...
Source: Chinese Journal of Integrative Medicine - December 7, 2021 Category: Internal Medicine Source Type: research

Seabuckthorn Berries Extract Attenuates Pulmonary Vascular Hyperpermeability in Lipopolysaccharide-Induced Acute Lung Injury in Mice
AbstractObjectiveTo investigate the effect of seabuckthorn berries extract (SBE) on pulmonary vascular hyperpermeability in the mice model of acute lung injury (ALI) induced by lipopolysaccharide (LPS).MethodsSixty Kunming mice were allocated into 6 groups by a random number table, including control, LPS, dexamethasone (Dex, 1 mg/kg), and 120, 240 and 480 mg/kg SBE groups, 10 mice in each group. Except the control group, mice were pre-treated with Dex and SBE, respectively, for 7 days before LPS was intraperitoneally injected to induce ALI. Pulmonary vascular hyperpermeability was evaluated by histopathologic observation a...
Source: Chinese Journal of Integrative Medicine - December 7, 2021 Category: Internal Medicine Source Type: research

Effect of Shenmai Injection ( 参麦注射液) on Long-Term Prognosis of Patients with Chronic Heart Failure: A Multicenter, Large Sample Capacity, Long-Term Follow-Up Retrospective Cohort Study
ConclusionCombination with SMI on the standardized Western medicine treatment can effectively reduce cardiogenic mortality and readmission rate in CHF patients, and thereby improve the long-term prognosis. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 7, 2021 Category: Internal Medicine Source Type: research

Huangqin Decoction Attenuates DSS-Induced Mucosal Damage and Promotes Epithelial Repair via Inhibiting TNF- α-Induced NF-κB Activation
AbstractObjectiveTo investigate the protective effect of Chinese herbal formula Huangqin Decoction (HQD) on ulcerative colitis mouse model induced by dextran sulphate sodium (DSS) and human intestinal epithelial cell injury induced by tumour necrosis factor- α (TNF-α).MethodsIn vivo, 30 male C57BL/6 mice were divided into 5 groups using a random number table (n=6 per group), including control, DSS, 5-aminosalicylic acid (5-ASA), HQD low- (HQD-L) and high-dose (HQD-H) groups. The colitis mouse model was established by 3% (w/v) DSS water for 5 days. Meanwhile, mice in the HQD-L, HQD-H and 5-ASA groups were admini...
Source: Chinese Journal of Integrative Medicine - December 7, 2021 Category: Internal Medicine Source Type: research

Effect of Interactive Dynamic Scalp Acupuncture on Post-Stroke Cognitive Function, Depression, and Anxiety: A Multicenter, Randomized, Controlled Trial
AbstractObjectiveTo compare the clinical effects of interactive dynamic scalp acupuncture (IDSA), simple combination therapy (SCT), and traditional scalp acupuncture (TSA) on cognitive function, depression and anxiety in patients with post-stroke cognitive impairment.MethodsA total of 660 patients with post-stroke cognitive impairment who were admitted to 3 hospitals in Shenzhen City between May 2017 and May 2020 were recruited and randomly assigned to the IDSA (218 cases), SCT (222 cases) and TSA groups (220 cases) according to a random number table. All the patients received conventional drug therapy for cerebral stroke ...
Source: Chinese Journal of Integrative Medicine - December 7, 2021 Category: Internal Medicine Source Type: research

Lycium barbarum Polysaccharides Promotes Mitochondrial Biogenesis and Energy Balance in a NAFLD Cell Model
AbstractObjectiveTo explore the protective effect and underlying mechanism ofLycium barbarum polysaccharides (LBP) in a non-alcoholic fatty liver disease (NAFLD) cell model.MethodsNormal human hepatocyte LO2 cells were treated with 1 mmol/L free fatty acids (FFA) mixture for 24 h to induce NAFLD cell model. Cells were divided into 5 groups, including control, model, low-, medium- and high dose LBP (30,100 and 300 µg/mL) groups. The monosaccharide components of LBP were analyzed with high performance liquid chromatography. Effects of LBP on cell viability and intracellular lipid accumulation were assessed by cell coun...
Source: Chinese Journal of Integrative Medicine - December 7, 2021 Category: Internal Medicine Source Type: research

Xuebijing Injection Ameliorates H2S-Induced Acute Respiratory Distress Syndrome by Promoting Claudin-5 Expression
AbstractObjectiveTo investigate the protective effects and underlying mechanisms of Xuebijing Injection (XBJ) on the lung endothelial barrier in hydrogen sulfide (H2S)-induced acute respiratory distress syndrome (ARDS).MethodsSprague-Dawley rats were exposed to H2S (300 ppm) to establish ARDS model, while human pulmonary microvascular endothelial cells (HPMECs) were incubated with NaHS (a H2S donor, 500 µmol/L) to establish cell model. H2S and XBJ were concurrently administered to the rat and cell models. Lung hematoxylin and eosin staining, immunohistochemistry, transmission electron microscopy and wet/dry ratio mea...
Source: Chinese Journal of Integrative Medicine - December 7, 2021 Category: Internal Medicine Source Type: research

Excessive Intake of Gardenia Pigments Requires Vigilance against Accumulation Risk
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 7, 2021 Category: Internal Medicine Source Type: research

Electroacupuncture Attenuated Phenotype Transformation of Vascular Smooth Muscle Cells via PI3K/Akt and MAPK Signaling Pathways in Spontaneous Hypertensive Rats
AbstractObjectiveTo investigate whether the antihypertensive mechanism of electroacupuncture (EA) is associated with attenuating phenotype transformation of vascular smooth muscle cells (VSMCs) via phosphoinositide3-kinase (PI3K)/protein kinase B (Akt) and mitogen-activated protein kinase (MAPK) signaling pathways.MethodsEight Wistar-ktoyo (WKY) rats were set as normal blood pressure group (normal group). A total of 32 spontaneous hypertensive rats (SHRs) were randomly divided into 4 groups using random number tables: a model group, an EA group, an EA+PI3K antagonist group (EA+P group), and an EA+p38 MAPK agonist+extracell...
Source: Chinese Journal of Integrative Medicine - November 28, 2021 Category: Internal Medicine Source Type: research

Bufalin Induces Programmed Necroptosis in Triple-Negative Breast Cancer Drug-Resistant Cell Lines through RIP1/ROS-Mediated Pathway
AbstractObjectiveTo explore the effect and mechanism of action of bufalin in triple-negative breast cancer (TNBC) drug-resistant cell lines.MethodsThe normal human mammary epithelial cell line, TNBC cell line, TNBC adriamycin-resistant cell line, and TNBC docetaxel-resistant cell line were treated with different doses of bufalin (0 –1,000 nmol/L) at different time points (0–72 h). Propidium iodide staining, AV-FITC/PI double staining, Hoechst 33342/PI double staining and transmission electron microscopy (TEM) were used to evaluate the death patterns of the cell lines.ResultsBufalin killed the TNBC cell line and...
Source: Chinese Journal of Integrative Medicine - November 26, 2021 Category: Internal Medicine Source Type: research

Lingbao Huxin Pill Alleviates Apoptosis and Inflammation at Infarct Border Zone through SIRT1-Mediated FOXO1 and NF- κ B Pathways in Rat Model of Acute Myocardial Infarction
In this study, left anterior descending coronary artery (LADCA) ligation was performed to induce an AMI model in rats. The myocardial infarction area was examined using a 2,3,5-triphenyltetrazolium chloride solution staining assay. A TdT-mediated dUTP nick-end labeling (TUNEL) assay was conducted to assess cardiomyocyte apoptosis in the IBZ. The histopathology of myocardial tissue at the IBZ was assessed with Heidenhain, Masson and hematoxylineosin (HE) staining assays. The expression levels of tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-1 β, and intercellular adhesion molecule-1 were measured ...
Source: Chinese Journal of Integrative Medicine - November 26, 2021 Category: Internal Medicine Source Type: research

Protective Effect of Fresh/Dry Dandelion Extracts on APAP-Overdose-Induced Acute Liver Injury
AbstractObjecitvieTo compare the liver protective activity of fresh/dried dandelion extracts against acetaminophen (APAP)-induced hepatotoxicity.MethodsTotally 90 Kunming mice were randomly divided into 10 groups according to body weight (9 mice for each group). The mice in the normal control and model (vehicle control) groups were administered sodium carboxymethyl cellulose (CMC-Na, 0.5%) only. Administration groups were pretreated with high and low-dose dry dandelion extract (1,000 or 500 g fresh herb dried and then decocted into 120 mL solution, DDE-H and DDE-L); low-, medium- and high-dose dandelion juice (250, 500, 1,...
Source: Chinese Journal of Integrative Medicine - November 24, 2021 Category: Internal Medicine Source Type: research

Amygdalin Ameliorates Liver Fibrosis through Inhibiting Activation of TGF- β/Smad Signaling
AbstractObjectiveTo observe the effect of amygdalin on liver fibrosis in a liver fibrosis mouse model, and the underlying mechanisms were partly dissectedin vivo andin vitro.MethodsThirty-two male mice were randomly divided into 4 groups, including control, model, low- and high-dose amygdalin-treated groups, 8 mice in each group. Except the control group, mice in the other groups were injected intraperitoneally with 10% carbon tetrachloride (CCl4)-olive oil solution 3 times a week for 6 weeks to induce liver fibrosis. At the first 3 weeks, amygdalin (1.35 and 2.7 mg/kg body weight) were administered by gavage once a day. M...
Source: Chinese Journal of Integrative Medicine - November 24, 2021 Category: Internal Medicine Source Type: research

Influence of Acupuncture on Microcirculation Perfusion of Pericardium Meridian and Heart in Acute Myocardial Ischemia Model Rats
AbstractObjectiveTo observe the influence of acupuncture on microcirculation perfusion of the pericardium meridian and heart in acute myocardial ischemia (AMI) rats and evaluate whether acupuncture can simultaneously affect the meridians and corresponding viscera. Additionally, acupoints at different meridians were compared and whether they exert the same effects was discussed.MethodsTotally 32 Sprague-Dawley rats were subjected to left anterior descending (LAD) ligation to develop an AMI model. Rats were divided into 4 groups, including AMI, acupuncture Neiguan (PC 6), Lieque (LU 7) and Qiansanli (LI 10) groups (n=8). Eig...
Source: Chinese Journal of Integrative Medicine - November 24, 2021 Category: Internal Medicine Source Type: research

Ineffectiveness of Skin Tests in Predicting Allergic Reactions Induced by Chinese Herbal Injections
ConclusionSkin tests are insufficient to predict the likelihood of allergic reactions resulting from CHIs. (ChiCTR-CPC-15006921) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 24, 2021 Category: Internal Medicine Source Type: research

Effects of Transcutaneous Electrical Acupoint Stimulation on Ovarian Responses and Pregnancy Outcomes in Patients Undergoing IVF-ET: A Randomized Controlled Trial
ConclusionsTEAS is an effective method in improving the ovarian state. When the stimulus intensity was at 40 mA and above, it could be helpful to improve the patient ’s endometrial condition and endometrial receptivity and to retrieve more oocytes. (Trial registration No. ChiCTR-TRC-11001780) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 10, 2021 Category: Internal Medicine Source Type: research

Mechanisms of Dangua Recipe in Improving Glycolipid Metabolic Disorders Based on Transcriptomics
AbstractObjectiveTo explore the mechanisms of Dangua Recipe (DGR) in improving glycolipid metabolism based on transcriptomics.MethodsSprague-Dawley rats with normal glucose level were divided into 3 groups according to a random number table, including a conventional diet group (Group A), a DGR group (Group B, high-calorie diet + 20.5 g DGR), and a high-calorie fodder model group (Group C). After 12 weeks of intervention, the liver tissue of rats was taken. Gene sequence and transcriptional analysis were performed to identify the key genes related to glycolipid metabolism reflecting DGR efficacy, and then gene or protein va...
Source: Chinese Journal of Integrative Medicine - November 10, 2021 Category: Internal Medicine Source Type: research

Protective Effects of Anthocyanins Extracted from Vaccinium Uliginosum on 661W Cells Against Microwave-Induced Retinal Damage
AbstractObjectiveTo study the protective effect of anthocyanins extracted fromVaccinium Uliginosum (VU) on retinal 661W cells against microwave radiation induced retinal injury.Methods661W cells were divided into 6 groups, including control, model [661W cells radiated by microwave (30 mW/cm2, 1 h)] and VU groups [661W cells pretreated with anthocyanins extracted from VU (25, 50, 100 and 200 µg/mL, respectively) for 48 h, and radiated by microwave 30 mW/cm2, 1 h]. After treatment with different interventions, the cell apoptosis index (AI) was determined using Heochst staining; contents of malonaldehyde (MDA), glutatai...
Source: Chinese Journal of Integrative Medicine - November 10, 2021 Category: Internal Medicine Source Type: research

Gallic Acid: A Potential Anti-Cancer Agent
AbstractCancer is one of the most devastating diseases worldwide and definitive therapeutics for treating cancer are not yet available despite extensive research efforts. The key challenges include limiting factors connected with traditional chemotherapeutics, primarily drug resistance, low response rates, and adverse side-effects. Therefore, there is a high demand for novel anti-cancer drugs that are both potent and safe for cancer prevention and treatment. Gallic acid (GA), a natural botanic phenolic compound, can mediate various therapeutic properties that are involved in anti-inflammation, anti-obesity, and anti-cancer...
Source: Chinese Journal of Integrative Medicine - November 10, 2021 Category: Internal Medicine Source Type: research

Efficacy of Quxie Capsule in Metastatic Colorectal Cancer: Long-Term Survival Update of A Double-Blind, Randomized, Placebo Controlled Trial
AbstractObjectiveTo verify the efficacy of Quxie Capsule in patients with metastatic colorectal cancer (mCRC).MethodsIt was a block randomized, double-blind, placebo-controlled trial. Sixty patients with mCRC were randomized into 2 groups at a 1:1 ratio. The patients in the treatment group received conventional therapy including chemotherapy, radiotherapy, targeted therapy and supportive care, and Chinese herbal medicine combined with Quxie Capsule (each capsule of 0.4 g was orally administered at 50 mg/kg, twice daily, day 1 –20, in a 30-day course) for 3 months. The patients in the control group received convention...
Source: Chinese Journal of Integrative Medicine - November 10, 2021 Category: Internal Medicine Source Type: research

Integration of Gut Microbiota and Metabolomics for Chinese Medicines Research: Opportunities and Challenges
AbstractChinese medicines (CM) are gaining more attentions from all over the world. However, there are a large body of questions to be answered because of the chemical complexity of CM and intricate molecular reactions within human body. In recent years, gut microbiota and metabolomics have emerged as two cynosures in deciphering the mechanisms of how our body is functioning. Since gut microbiota and host is a closely interrelated system, paying attention only to gut microbiota or metabolites may omit the interplays among CM, gut microbiota, and hosts. To systemically study these interplays, a network understanding of CM c...
Source: Chinese Journal of Integrative Medicine - November 10, 2021 Category: Internal Medicine Source Type: research

Sijunzi Decoction Inhibits Stemness by Suppressing β-Catenin Transcriptional Activity in Gastric Cancer Cells
AbstractObjectiveTo investigate a previously uncharacterized function of Sijunzi Decoction (SJZD) in inhibition of gastric cancer stem cells (GCSCs).MethodsMKN74 and MKN45, two CD44 positive gastric cancer cell lines with stem cell properties were used. The cells were divided into 2 groups. Treatment group was treated with SJZD (1 –5 mg/mL) for indicated time (48 h–14 days). The control group was treated with equal volume of phosphate buffered saline. Cell Counting Assay Kit-8 were used to measure cell viability. Spheroid colony formation and GCSCs marker expression were performed to determine GCSCs stemness. C...
Source: Chinese Journal of Integrative Medicine - November 9, 2021 Category: Internal Medicine Source Type: research

Acupoint Injection Decreases Anesthetic Cosumption during Combined Spinal-Epidural and Patient-Controlled Epidural Labor Analgesia
AbstractObjectiveTo explore if acupoint injection can improve analgesic effects or delivery outcomes in parturients who received combined spinal-epidural analgesia (CSEA) and patient-controlled epidural analgesia (PCEA) for labor analgesia.MethodsA total of 307 participants were prospectively collected from July 2017 to December 2019. The participants were randomized into the combined acupoint injection with CSEA plus PCEA group (AICP group,n=168) and CSEA plus PCEA group (CP group,n=139) for labor analgesia using a random number table. Both groups received CSEA plus PCEA at cervical dilation 3 cm during labor process, and...
Source: Chinese Journal of Integrative Medicine - November 3, 2021 Category: Internal Medicine Source Type: research