Low Electrical Resistance Properties of Acupoints: Roles of NOergic Signaling Molecules and Neuropeptides in Skin Electrical Conductance
AbstractEarly studies from several independent laboratories demonstrated that acupoints possess the characteristics of low electrical resistance. New devices are developing to increase the reliability of electrical skin impedance measurements for counteracting the factors including skin dryness, skin thickness, size of the sensing electrode, pressure applied on the electrode, interelectrode distance, room temperature, and humidity. Morphological studies have identified that blood vessels, hair follicles, and nervous components are enhanced in the meridians/acupoints, which represent areas of potentially high neuronal activ...
Source: Chinese Journal of Integrative Medicine - July 28, 2021 Category: Internal Medicine Source Type: research

Arsenic Trioxide Combining Leflunomide Activates Nrf2-ARE-HO-1 Signaling Pathway and Protects Heart Xenografts
AbstractObjectiveTo investigate the molecular mechanisms underlying the effects of arsenic trioxide (As2O3) in combination with leflunomide on the hamster-to-rat heart xenotransplant.MethodsTransplantation of LVG hamster hearts to Lewis rats was performed by anastomosis of vessels in the neck using end-to-end anastomosis with a non-suture cuff technique. Four groups of recipient rats (n=6 in each) were treated with normal saline (control), As2O3 [5 mg/(kg ·day) intraperitoneally], leflunomide [5 mg/(kg·d) orally], or leflunomide [5 mg/(kg·d)+As2O3 [5 mg/(kg ·d)] in combination. Donor hearts and/...
Source: Chinese Journal of Integrative Medicine - July 28, 2021 Category: Internal Medicine Source Type: research

Extract from Zanthoxylum piperitum Induces Apoptosis of AGS Gastric Cancer Cells Through Akt/MDM2/p53 Signaling Pathway
AbstractObjectiveTo determine the effect of Zanthoxylum piperitum extracet (ZPE) on apoptosis and analyze anticancer substances in ZPE, changes in proteins related to apoptosis, and pathological changes in tumors in mouse.MethodsFifteen 4-week-old female BALB/c nu/nu mice were divided into 3 groups depending on ZPE dose, with 5 in each group. AGS gastric carcinoma cells (1 × 106 cells/200 µL) were subcutaneously injected into the flank of each mouse. One week after the injection of AGS cells, ZPE was administered to the skin tissue [10 or 50 mg/(kg·d)] in the low- and high-dose groups, respectively for 2...
Source: Chinese Journal of Integrative Medicine - July 28, 2021 Category: Internal Medicine Source Type: research

Chinese Herbal Medicine for Systemic Lupus Erythematosus: A Systematic Review and Meta-analysis of Randomized, Placebo-Controlled Trials
ConclusionsCHM provided significant beneficial effect on controlling disease activity and reducing dose of glucocorticoids used among SLE patients. Future advanced designed RCTs for CHM treating moderate to severe SLE with multicenter and longer follow-up are urgently needed. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 28, 2021 Category: Internal Medicine Source Type: research

Impact of Low Frequency Electro-acupuncture on Glucose and Lipid Metabolism in Unmarried PCOS Women: A Randomized Controlled Trial
AbstractObjectiveTo explore the effect of electro-acupuncture (EA) on glucose and lipid metabolism in unmarried patients with polycystic ovary syndrome (PCOS).MethodsFifty-four PCOS patients were equally randomized into true acupuncture group and sham acupuncture group (control) for totally 16 weeks of treatment by random method with a computerized randomization program. Patients in true acupuncture group accepted traditional acupuncture methods with EA and two sets of acupoint groups were used alternatively. The first set consisted of Zhongji (CV 3), Qihai (CV 6), Guilai (ST 29), Sanyinjiao (SP 6), Yinlingquan (SP 9), Heg...
Source: Chinese Journal of Integrative Medicine - July 28, 2021 Category: Internal Medicine Source Type: research

Prevalence and Factors Associated with Concomitant Chinese Medicine Use by Rheumatoid Arthritis Patients in A Multi-Ethnic Asian Population
ConclusionsConcomitant CM use among patients with RA treated in a tertiary referral centre in Singapore is high but voluntary disclosure is low. The associations identified can help doctors identify and enquire about CM use, minimizing potential adverse interactions. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 28, 2021 Category: Internal Medicine Source Type: research

Effect of Curcumol on NOD-Like Receptor Thermoprotein Domain 3 Inflammasomes in Liver Fibrosis of Mice
AbstractObjectiveTo investigate the effect of curcumol on NOD-like receptor thermoprotein domain 3 (NLRP3) inflammasomes, and analyze the mechanism underlying curcumol against liver fibrosis.MethodsThirty Kunming mice were divided into a control group, a model group and a curcumol group according to a random number table, 10 mice in each group. Mice were intraperitoneally injected with 40% carbon tetrachloride (CCl4:peanut oil, 2:3 preparation) at 5 mL/kg for 6 weeks, twice a week, for developing a liver fibrosis model. The mice in the control group were given the same amount of peanut oil twice a week for 6 weeks. The mic...
Source: Chinese Journal of Integrative Medicine - July 28, 2021 Category: Internal Medicine Source Type: research

Is Regular Probiotic Practice Safe for Management of Sepsis?
AbstractFor decades, the gut has been thought to play an important role in sepsis pathogenesis. Sepsis is a serious life-threatening, chronic condition of an infection caused by dysregulated host immune response in most of the intensive care unit patients. Probiotics have dual roles in polymicrobial sepsis i.e. probiotics may induce sepsis in many cases and may prevent its prognosis in many cases. Experimental evidence from both pre-clinical and clinical studies have demonstrated that probiotic therapy ameliorates various inflammatory mediators such as tumor necrosis factor, interleukin-10 (IL-10), IL-6, etc., in septicemi...
Source: Chinese Journal of Integrative Medicine - July 16, 2021 Category: Internal Medicine Source Type: research

Effects of Danhong Injection ( 丹红注射液) on Peri-Procedural Myocardial Injury and Microcirculatory Resistance in Patients with Unstable Angina Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study
ConclusionThis study demonstrated benefit of DH in reducing myocardial injury and potential preserving microvascular function in patients with unstable angina undergoing elective PCI. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 14, 2021 Category: Internal Medicine Source Type: research

Traditional Chinese Medicine and Traditional Indonesian Medicine: A Comparative Review of Herbal Medicines Restricted in Pregnancy
AbstractThe decline in birth rates has become a very serious problem in various parts of the world. Many countries have implemented national programs for increasing birth rates, one of which involves the use of traditional medicine as an alternative solution. Among the fast-growing traditional medicines, traditional Chinese medicine (TCM) and traditional Indonesian medicine (TIM) have attracted a lot of demand globally. Here, we analyzed and compared the herbal medicines from TCM and TIM that must be avoided by pregnant women for preventing miscarriage and maintaining safety during pregnancy and the postpartum period. This...
Source: Chinese Journal of Integrative Medicine - July 9, 2021 Category: Internal Medicine Source Type: research

Chinese Medicine Regulates DNA Methylation to Treat Haematological Malignancies: A New Paradigm of “State-Target Medicine”
AbstractAberrant regulation of DNA methylation plays a crucial causative role in haematological malignancies (HMs). Targeted therapy, aiming for DNA methylation, is an effective mainstay of modern medicine; however, many issues remain to be addressed. The progress of epigenetic studies and the proposed theory of “state-target medicine” have provided conditions to form a new treatment paradigm that combines the “body state adjustment” of CM with targeted therapy. We discussed the correlation between Chinese medicine (CM) syndromes/states and DNA methylation in this paper. Additionally, the latest res...
Source: Chinese Journal of Integrative Medicine - July 9, 2021 Category: Internal Medicine Source Type: research

Efficacy and Mechanism of Buxue Yimu Pills ( 补血益母丸) on Gynecological Anemia: A Combination of Clinical and Network Pharmacology Study
ConclusionBYP contributes to the practical improvement on gynecological anemia potentially through multi-target mechanisms and optimized iron re-distribution. (Trial registration: No. NCT03232554) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 9, 2021 Category: Internal Medicine Source Type: research

Mechanism of Shengmai Injection ( 生脉注射液) on Anti-Sepsis and Protective Activities of Intestinal Mucosal Barrier in Mice
AbstractObjectiveTo study the mechanism of Shengmai Injection (SMI, 生脉注射液) on anti-sepsis and protective activities of intestinal mucosal barrier.MethodsThe contents of 11 active components of SMI including ginsenoside Rb1, Rb2, Rb3, Rd, Re, Rf, Rg1, Rg2, ophioposide D, schisandrol A and schisantherin A were determined using ultra-performance liquid chromatography. Fifty mice were randomly divided into the blank, the model, the low-, medium- and high-dose SMI groups (0.375, 0.75, 1.5 mL/kg, respectively) by random number table, 10 mice in each group. In SMI group, SMI was administrated to mice daily via tail vein...
Source: Chinese Journal of Integrative Medicine - July 9, 2021 Category: Internal Medicine Source Type: research

Effect of Weikang Capsule ( 胃康胶囊) on Aspirin-Related Gastric and Small Intestinal Mucosal Injury
AbstractObjectiveTo investigate the effects of Weikang Capsule ( 胃康胶囊, WKC) on aspirin-related gastric and small intestinal mucosal injury by magnetically controlled capsule endoscopy (MCCE).MethodsPatients taking enteric-coated aspirin aged 40 –75 years were enrolled in Beijing Anzhen Hospital, Capital Medical University from January 2019 to December 2019. The patients continued taking aspirin Tablet (100 mg per day) and underwent MCCE before and after 1-month combined treatment with WKC (0.9 g per time orally, 3 times per day). The gas trointestinal symptom score, gastric Lanza score, the duodenal, jejunal ...
Source: Chinese Journal of Integrative Medicine - June 8, 2021 Category: Internal Medicine Source Type: research

Ethyl Acetate Fraction of Dicliptera chinensis (L.) Juss. Ameliorates Liver Fibrosis by Inducing Autophagy via PI3K/AKT/mTOR/p70S6K Signaling Pathway
AbstractObjectiveTo investigate the molecular mechanism underlying the anti-hepatic fibrosis activity of ethyl acetate fractionDicliptera chinensis (L.) Juss. (EDC) in human hepatic stellate cells (HSCs)in vitro and in a carbon tetrachloride (CCl4)-induced hepatic fibrosis mouse modelin vivo.MethodsForin vitro study, HSCs were pre-treated with platelet-derived growth factor (10 ng/mL) for 2 h to ensure activation and treated with EDC for 24 h and 48 h, respectively. The effect of EDC on HSCs was assessed using cell counting kit-8 assay, EdU staining, transmission electron microscopy, immunofluorescence staining, and Wester...
Source: Chinese Journal of Integrative Medicine - June 8, 2021 Category: Internal Medicine Source Type: research

Bee Venom Acupuncture Induced Skin Patch Discoloration Persisting for More Than 3 Years: A Case Report
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - June 8, 2021 Category: Internal Medicine Source Type: research

Monoclonal Gammopathy of Renal Significance (MGRS): Prospects for Treatment in Integrated Chinese and Western Medicine
AbstractMonoclonal gammopathy of renal significance (MGRS) is a pathological state which presents with a spectrum of renal lesions. MGRS is characterized by pathogenic monoclonal immunoglobulins or light chains produced by a premalignant plasma cell or B cell clone. In view of inadequate understanding in the past, the low detection rate of MGRS often results in poor outcomes and reduces quality of life of patients. Thus, MGRS stands for a group of clinical refractory renal diseases. To date, no standard treatment strategy for MGRS is available. Current consensus suggests a clone-directed approach that aims to eradicate the...
Source: Chinese Journal of Integrative Medicine - June 8, 2021 Category: Internal Medicine Source Type: research

Identification of Hypertension Subgroups through Topological Analysis of Symptom-Based Patient Similarity
ConclusionThe utility and comprehensiveness of disease classification based on community detection of patient networks using shared CM symptom phenotypes showed the importance of hypertension patient subgroups. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - May 31, 2021 Category: Internal Medicine Source Type: research

Advances in Treatment of Post-Traumatic Stress Disorder with Chinese Medicine
This article summarizes the cellular and animal experimental mechanisms of CM treatment on PTSD, suggesting that traditional Chinese herbs and acupuncture can protect brain functional areas, an d adjust hypothalamus-pituitary-adrenal axis. Traditional Chinese herbs and acupuncture have shown good anti-stress efficacy and fewer side effects in clinical application, which may improve the CSR in the battlefield. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - May 31, 2021 Category: Internal Medicine Source Type: research

Kuanxiong Aerosol ( 宽胸气雾剂) in Treatment of Angina Pectoris: A Literature Review and Network Pharmacology
AbstractAngina pectoris (AP) is the most common symptom of cardiovascular diseases, which seriously affects the quality of life in cardiovascular patients. Kuanxiong (KX) Aerosol ( 宽胸气雾剂), a compound preparation that consists of 5 traditional Chinese medicines:Herba Asari , Rhizoma Alpiniae Officinarum, Lignum Santali Albi, Fructus Piperis Longi, andBorneolum, has been used in the treatment of AP for many years, exhibiting a significant curative effect and less side-effect. For the convenience and comprehensive understanding of KX Aerosol, this review systematically summarizes evidence on KX Aerosol in the treatm...
Source: Chinese Journal of Integrative Medicine - May 28, 2021 Category: Internal Medicine Source Type: research

Chinese Medicine Rescues Acute Respiratory Dyspnea Syndrome Caused by COVID-19: A Case Report
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - May 25, 2021 Category: Internal Medicine Source Type: research

Curcumin Inhibits Viability of Clear Cell Renal Cell Carcinoma by Down-Regulating ADAMTS18 Gene Methylation though NF- κ B and AKT Signaling Pathway
AbstractObjectiveTo investigate the effect of curcumin on viability of clear cell renal cell carcinoma (ccRCC) and analyze its possible mechanism.MethodsIn cell lines of A498 and 786-O, the effects of curcumin (1.25, 2.5, 5 and 10 μ mol/L) on the viability of ccRCC were analyzed at 24, 48 and 72 h by MTT assay. The protein expression levels of ADAMTS18 gene, p65, phosphorylation p65 (pp65), AKT, phosphorylation AKT (pAKT) and matrix metallopeptidase 2 (MMP-2) before and after curcumin (10 μ mol/L) treatment were examined by Western blotting. Real-time PCR and methylation specific PCR (MSP) were applied to analyze the...
Source: Chinese Journal of Integrative Medicine - May 17, 2021 Category: Internal Medicine Source Type: research

Landscape of Hepatobiliary Adverse Drug Reactions Related to Preparations Containing Psoraleae Fructus and Its Application in Pharmacovigilance
AbstractObjectiveTo analyze clinical feature and information of medication to explore the risk signals of preparations containingPsoraleae Fructus (BGZP) related with hepatobiliary adverse drug reactions (ADR), in order to reinforce pharmacovigilance.MethodsA retrospective study was conducted based on hepatobiliary ADR related with BGZP from the China Adverse Drug Reaction Monitoring System in years from January 2012 to December 2016. Serious and general ADRs were analyzed and assessed.ResultsThere were 355 cases of hepatobiliary ADR related to BGZP. Both the amount of cases and the proportion of serious ADR showed an incr...
Source: Chinese Journal of Integrative Medicine - May 8, 2021 Category: Internal Medicine Source Type: research

β -Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency—A Randomized, Placebo-Controlled, and Double-Blinded Trial
Conclusionsβ -glucan ameliorates PQi in PQD individuals. By using stringent evidence-based methodologies, our study demonstrated that Western medicine-derived remedies, such as β -glucan, can be employed to advance CM therapeutics. (ClinicalTrial.Gov registry: NCT03782974) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - May 8, 2021 Category: Internal Medicine Source Type: research

Treatment of End-Stage Coronary Artery Disease with the Mode of Combination of Disease and Syndrome: A Case Report
ConclusionAlthough cardiovascular mortality in end-stage CAD patient has declined due to improved secondary prevention, but new therapeutic strategies remains required. Transmyocardial laser revascularization, cardiac shock wave therapy, gene therapeutics and heart transplantation have now been accepted treatments for end-stage CAD, but remains lack of adequate clinical evidence. This case report showed that integrative medicine can awaken hibernation myocardium and reduction in symptoms of angina. Besides, psychology, rehabilitation, medical treatment and invasive interventions participate in the treatment of diseases tog...
Source: Chinese Journal of Integrative Medicine - April 24, 2021 Category: Internal Medicine Source Type: research

Safety of Thread Embedding Acupuncture Therapy: A Systematic Review
ConclusionsThe evidence showed that TEAT is a relatively safe and convenient therapy especially since application of new absorbable surgical suture. Improving practitioner skills, regulating operations, and paying attention to the patients ’ conditions may reduce the incidence of AEs and improve safety of TEAT. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - April 24, 2021 Category: Internal Medicine Source Type: research

Efficacy of Yangyin Yiqi Huoxue Granule ( 养阴益气活血颗粒) in Treatment of Ischemic Stroke Patients with Qi-Yin Deficiency and Blood Stasis Syndrome: A Randomized, Double-Blind, Multicenter, Phase-2 Clinical Trial
AbstractObjectiveTo evaluate the efficacy and safety of Yangyin Yiqi Huoxue Granule ( 养阴益气活血颗粒, YYHG) in the treatment of ischemic stroke (IS) patients with qi-yin deficiency and blood stasis syndrome (QYDBSS), and to explore its effective dosage.MethodsThe total of 288 patients were randomly assigned to the YYHG high-dose, YYHG low-dose, positive control (administered Xiaoshuantong Granule, XSTG, 消栓通颗粒), or placebo control (administered inert granule) groups (72 cases per group) by software-drived competitive block randomization. The trial was conducted for a 28-day period, with a 180-day follow-...
Source: Chinese Journal of Integrative Medicine - April 21, 2021 Category: Internal Medicine Source Type: research

Effect and Safety of Penetrating Moxibustion in Treatment of Migraine without Aura: A Randomized Controlled Trial
AbstractObjectiveTo observe the clinical effect of penetrating moxibustion on migraine without aura (MO) patients.MethodsTotally 60 MO patients from the Acupuncture Clinic of the Third Affiliated Hospital of Henan University of Chinese Medicine were collected from November 2015 to February 2017. All patients were assigned to a treatment group and a control group using a random number table, 30 cases in each group. The treatment group was treated with penetrating moxibustion, and the control group was treated with mild moxibustion, thrice a week for 4 consecutive weeks. The total effective rate, Visual Analogue Scale (VAS) ...
Source: Chinese Journal of Integrative Medicine - April 21, 2021 Category: Internal Medicine Source Type: research

Post-Marketing Surveillance of Qishe Pill ( 芪麝丸) Use for Management of Neck Pain in a Chinese Patient Cohort to Determine its Safety, Tolerability and Effectiveness
ConclusionThese findings showed that patients with cervical radiculopathy who received Qishe Pill experienced significant improvement on pain and function. (Registration No. NCT01875562) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - April 21, 2021 Category: Internal Medicine Source Type: research

Low-Frequency Magnetic Stimulation of Shenmen Acupoint Reduces Blood Oxygen Levels in the Prefrontal Cortex of Healthy Subjects: A Near-Infrared Brain Functional Imaging Study
AbstractObjectiveTo explore the effect of low-frequency magnetic stimulation at Shenmen (HT 7) acupoint on blood oxygen levels in the prefrontal cortex of healthy subjects.MethodsFunctional near-infrared spectroscopy (fNIRS) technology was used to collect real-time data of oxygenated hemoglobin (oxy-Hb) in the prefrontal cortex of 16 healthy subjects at resting state and low-frequency magnetic stimulation of Shenmen. The mean and integral values of blood oxygen concentration were analyzed.ResultsCompared with the resting state, the mean and integral values of blood oxygen concentration were decreased during the task period...
Source: Chinese Journal of Integrative Medicine - April 21, 2021 Category: Internal Medicine Source Type: research

Analgesic Activity of Jin Ling Zi Powder ( 金铃子散) and Its Single Herbs: A Serum Metabonomics Study
AbstractObjectiveTo compare the analgesic effect of Jin Ling Zi Powder ( 金铃子散, JLZ) and its two single herbs.MethodsThe hot plate method was used to induce pain. Totally 36 mice were randomly divided into 6 groups by a complete random design, including control, model, aspirin (ASP, 0.14 g/kg body weight), JLZ (14 g/kg body weight),Corydalis yanhusuo (YHS, 14 g/kg body weight), andToosendan Fructus (TF, 14 g/kg body weight) groups, 6 mice in each group. The mice in the control and model groups were given the same volume of saline, daily for 2 consecutive weeks. At 30, 60, 90, and 120 min after the last administratio...
Source: Chinese Journal of Integrative Medicine - April 21, 2021 Category: Internal Medicine Source Type: research

Effectiveness and Safety of Moxibustion Robots on Primary Dysmenorrhea: A Randomized Controlled Pilot Trial
AbstractObjectiveTo conduct a pilot trial to explore the effectiveness and safety of moxibustion robots in treating primary dysmenorrhea (PD) and evaluate its feasibility in clinic.MethodsA total of 70 participants with PD were allocated to either moxibustion robot (MR) group (35 cases) or manual moxibustion (MM) group (35 cases) using computer-generated randomization. One acupoint Guanyuan (CV 4) was selected to receive moxa heat stimulation. Two groups of participants were given 3 menstrual cycles of MM and MR treatment respectively (once a day, 5 days a session) and received another 3 menstrual cycles follow-up. The deg...
Source: Chinese Journal of Integrative Medicine - April 10, 2021 Category: Internal Medicine Source Type: research

Treatment of Chronic Aplastic Anemia with Chinese Patent Medicine Pai-Neng-Da Capsule ( 派能达胶囊) for Replacing Androgen Partially: A Clinical Multi-Center Study
AbstractObjectiveTo evaluate the efficacy and safety of Pai-Neng-Da Capsule ( 派能达胶囊, panaxadiol saponins component, PNDC) in combination with the cyclosporine and androgen for patients with chronic aplastic anemia (CAA).MethodsA total of 79 CAA patients was randomly divided into 2 groups by a random number table, including PCA group [43 cases, orally PNDC 320 mg/d plus cyclosporine 5 mg/(kg ·d) plus andriol 80 mg/d] and CA group [36 cases, orally cyclosporine 5 mg/(kg·d) plus andriol 160 mg/d]. All patients were treated and followed-up for 6 treatment courses over 24 weeks. The complete blood counts...
Source: Chinese Journal of Integrative Medicine - April 10, 2021 Category: Internal Medicine Source Type: research

Protective Effect of Brassica napus L. Hydrosols against Inflammation Response in RAW 264.7 Cells
AbstractObjectiveTo demonstrate the anti-inflammatory activity ofBrassica napus L. hydrosols (BNH) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.MethodsComposition analysis of BNH was conducted via gas chromatography-mass spectrometry after BNH were extracted. The nitric oxide (NO) production was measured using the Griess assay. Prostaglandin E2 (PGE2) production was evaluated with enzyme-linked immunosorbent assay. The effects of BNH on LPS-induced pro-inflammatory enzymes including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were evaluated using Western blot analysis. Furthermore, phospho...
Source: Chinese Journal of Integrative Medicine - March 24, 2021 Category: Internal Medicine Source Type: research

Evidence-Based Immunotherapeutic Effects of Herbal Compounds on Humoral Immunity: Ancient and New Approaches
AbstractThe human immune system represents a dynamic multiscale system with high complexity in biology. Humoral immunity, as the main branch of adaptive immunity, is characterized by differentiated stages of the B lymphocytes, producing the final product of antibodies that has a diversity of the tuning mechanisms within genetic and epigenetic levels in confrontation with environmental exposures. Disorders because of disturbed humoral immunity are linked with dysregulation of feedback-regulated signaling and the dynamic of immune components that determine the overall response. Food products, mainly herbal components have a ...
Source: Chinese Journal of Integrative Medicine - March 24, 2021 Category: Internal Medicine Source Type: research

Effect of High Suspension and Low Incision Surgery Based on Traditional Ligation of Chinese Medicine in Treatment of Mixed Haemorrhoids: A Multi-centre, Randomized, Single-Blind, Non-inferiority Clinical Trial
AbstractObjectiveTo observe the clinical effect of high suspension and low incision (HSLI) surgery on mixed haemorrhoids, compared with Milligan-Morgan haemorrhoidectomy.MethodsA multi-centre, randomized, single-blind, non-inferiority clinical trial was performed. Participants with mixed haemorrhoids from Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing Rectum Hospital, Air Force Medical Center of People ’s Liberation Army of China, and Puyang Hospital of Traditional Chinese Medicine were enrolled from September 2016 to March 2018. By using a blocked randomization scheme, participants were assign...
Source: Chinese Journal of Integrative Medicine - March 12, 2021 Category: Internal Medicine Source Type: research

Electroacupuncture Attenuates Ischemic Brain Injury and Cellular Apoptosis via Mitochondrial Translocation of Cofilin
AbstractObjectiveTo investigate the potential mechanisms of electroacupuncture (EA) to prevent ischemic stroke.MethodsThe method of middle cerebral artery occlusion (MCAO) was employed to establish a rat model of ischemic stroke. Seventy-eight Sprague-Dawley rats were divided into the sham group, MCAO + EA control (EC) group, and MCAO + EA (EA) group according to a random number table (n=26 per group). EA was applied to the acupoints of Baihui (DU 20) and Shenting (DU 24) 5 min and 6 h, respectively after the onset of MCAO. Rats in the sham and EC groups received only light isoflurane anesthesia for 30 min after MCAO. The ...
Source: Chinese Journal of Integrative Medicine - March 12, 2021 Category: Internal Medicine Source Type: research

Chinese Medicine Involving Triple Rehabilitation Therapy ( 中医三联康复疗法) for Knee Osteoarthritis in 696 Outpatients: A Multi-Center, Randomized Controlled Trial
AbstractObjectiveTo determine the effects of Chinese medicine (CM) involving triple rehabilitation therapy ( 中医三联康复疗法) on the progression of knee osteoarthritis (KOA).MethodsA total of 722 patients recruited from 38 community health service centers located in China from March 2013 to March 2017 were randomly divided into treatment and control groups equally, using a cluster randomization design. Health education combined with CM involving triple rehabilitation therapy for KOA (electro-acupuncture, Chinese medicinal herb fumigating-washing, and traditional exercises) was administered in the treatment group w...
Source: Chinese Journal of Integrative Medicine - March 12, 2021 Category: Internal Medicine Source Type: research

Wide Pulse Width Electroacupuncture Ameliorates Denervation-Induced Skeletal Muscle Atrophy in Rats via IGF-1/PI3K/Akt Pathway
ConclusionsEA with 200-ms pulse width was found to have a more significant effect than 0.5-ms EA. The positive effects of EA disappeared after inhibition of the PI3K/Akt pathway. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - March 4, 2021 Category: Internal Medicine Source Type: research

Effect of Acupuncture on Ovary Morphology and Function in DHEA-Induced Polycystic Ovary Syndrome Model Rats
AbstractObjectiveTo investigate the effects of acupuncture on ovary morphology and function in dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) model rats.MethodsA total of 40 adult female Wistar rats were randomly allocated to 4 groups by a random number table, including control, model, metformin and acupuncture groups, 10 rats in each group. PCOS rat model was developed by injecting with DHEA (6 mg/100 g body weight) in 0.2 mL of oil subcutaneously. Electrical stimulation (2 Hz, 3 mA) was applied to Guanyuan (CV 4), Zigong (EX-CA1) and Qihai (CV 6) acupoints for 30 min daily in the acupuncture group...
Source: Chinese Journal of Integrative Medicine - March 1, 2021 Category: Internal Medicine Source Type: research

Therapeutic Effects of Different Animal Bile Powders on Lipid Metabolism Disorders and Their Composition Analysis
AbstractObjectiveTo compare the therapeutic effect of different animal bile powders on lipid metabolism disorders induced by high-fat diet in rats, and analyze the bioactive components of each animal bile powder.MethodsSixty Sprague-Dawley rats were randomly divided into 6 groups (n=10): normal diet control group, high-fat diet model group, high-fat diet groups orally treated with bear, pig, cow and chicken bile powders, respectively. Serum biochemical markers from the abdominal aorta in each group were analyzed. Changes in the body weight and liver weight were recorded. Pathohistological changes in the livers were examine...
Source: Chinese Journal of Integrative Medicine - February 20, 2021 Category: Internal Medicine Source Type: research

Promising Antiviral Molecules from Ayurvedic Herbs and Spices against COVID-19
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - February 5, 2021 Category: Internal Medicine Source Type: research

Effects of Chinese Medicine on Symptoms, Syndrome Evolution, and Lung Inflammation Absorption in COVID-19 Convalescent Patients during 84-Day Follow-up after Hospital Discharge: A Prospective Cohort and Nested Case-Control Study
This study was designed as a prospective cohort and nested case-control study. A total of 96 eligible patients with COVID-19 in convalescence were enrolled from Beijing Youan Hospital and Beijing Huimin Hospital and followed up from the hospital discharged day. Patients were divided into the CM (64 cases) and the control groups (32 cases) based on the treatment with or without CM and followed up at 14, 28, 56, and 84 days after discharge. In the CM group, patients received the 28-day CM treatment according to two types of CM syndrome. Improvements in clinical symptoms, CM syndrome, and absorption of lung inflammation were ...
Source: Chinese Journal of Integrative Medicine - February 3, 2021 Category: Internal Medicine Source Type: research

Thoughts on Traditional Chinese Medicine Treatment of Novel Coronavirus Pneumonia Based on Two Cases
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - February 2, 2021 Category: Internal Medicine Source Type: research

Antitumor Effects of Ethanol Extract from Ventilago leiocarpa Benth on Sarcoma 180 Tumor-Bearing Mice and Possible Immune Mechanism
AbstractObjectiveTo explore the antitumor effects of ethanol extract fromVentilago leiocarpa Benth (EEVLB) on sarcoma 180 (S180) tumor-bearing mice and the potential mechanism.MethodsSixty mice were randomly assigned to 6 groups according to a random number table: normal group, model group, 5-fluorouracil (5-FU) group (0.02 g ·kg−1), and high-, medium-, low-dose EEVLB groups (100, 84, and 56 g of raw material ·kg−1 body weight, respectively), with 10 mice each group. All treatments were given once daily for 10 consecutive days. Effects of EEVLB on inhibiting tumor growth and immune function in mic...
Source: Chinese Journal of Integrative Medicine - January 30, 2021 Category: Internal Medicine Source Type: research

Bloodletting Puncture at Hand Twelve Jing-Well Points Relieves Brain Edema after Severe Traumatic Brain Injury in Rats via Inhibiting MAPK Signaling Pathway
AbstractObjectiveTo investigate whether blood-brain barrier (BBB) served a key role in the edema-relief effect of bloodletting puncture at hand twelve Jing-well points (HTWP) in traumatic brain injury (TBI) and the potential molecular signaling pathways.MethodsAdult male Sprague-Dawley rats were assigned to the sham-operated (sham), TBI, and bloodletting puncture (bloodletting) groups (n=24 per group) using a randomized number table. The TBI model rats were induced by cortical contusion and then bloodletting puncture were performed at HTWP twice a day for 2 days. The neurological function and cerebral edema were evaluated ...
Source: Chinese Journal of Integrative Medicine - January 30, 2021 Category: Internal Medicine Source Type: research

Protective Effects of Hu-Lu-Ba-Wan ( 葫芦巴丸) against Oxidative Stress in Testis of Diabetic Rats through PKCα/NAPDH Oxidase Signaling Pathway
AbstractObjectiveTo explore the protective effect and the underlying mechanism of Hu-Lu-Ba-Wan ( 葫芦巴丸, HLBW) on the testis of diabetic rats.MethodsTwenty-four male Wistar rats (160 –180 g) were randomly divided into 3 groups according to a random number table, including a control group (n=8), diabetic group (n=8), and HLBW group (n=8). Diabetic rat model was established by high-fat-diet administration and single intravenous injection of streptozotocin (26 mg/kg). Then HLBW granule was administrated for 12 weeks. Fasting blood glucose and insulin levels as well as serum total testosterone level and testicular ...
Source: Chinese Journal of Integrative Medicine - January 15, 2021 Category: Internal Medicine Source Type: research

Panax Notoginseng Saponin Attenuates Gastric Mucosal Epithelial Cell Injury Induced by Dual Antiplatelet Drugs through COX and PI3K/Akt/ VEGF-GSK-3 β-RhoA Network Pathway
AbstractObjectiveTo elucidate the underlying mechanism ofPanax notoginseng saponin (PNS) on gastric epithelial cell injury and barrier dysfunction induced by dual antiplatelet (DA).MethodsHuman gastric mucosal epithelial cell (GES-1) was cultured and divided into 4 groups: a control, a DA, a PNS+DA and a LY294002+PNS+DA group. GES-1 apoptosis was detected by flow cytometry, cell permeability were detected using Transwell, level of prostaglandins E2 (PGE2), 6-keto-prostaglandin F1 α (6-keto-PGF1α) and vascular endothelial growth factor (VEGF) in supernatant were measured by enzyme linked immunosorbent assay (ELI...
Source: Chinese Journal of Integrative Medicine - January 15, 2021 Category: Internal Medicine Source Type: research

Homeostasis Research Model Based on Yin-Yang Theory: Five Examples
AbstractIn recent years, the ancient Yin-Yang theory has been gradually adopted by modern researchers, especially European and American scholars, and it has also been applied to modern scientific research on sleep, viruses, metabolism, cancer, genes, autoimmune diseases, and so on. It is very promising and fruitful results have been reported. However, the understanding of the connotations of Yin-Yang theory is not sufficient and thorough enough in these studies. If we understand and apply Yin-Yang theory more comprehensively, it may provide us with additional potential mechanisms and research directions worthy of study. On...
Source: Chinese Journal of Integrative Medicine - January 12, 2021 Category: Internal Medicine Source Type: research

Effect of Danhong Injection ( 丹红注射液) on Improving Coronary Microcirculation Injury after Percutaneous Coronary Intervention
AbstractObjectiveTo explore the effectiveness of Danhong Injection ( 丹红注射液) on improving microcirculatory injury after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD).MethodsA randomized controlled trial was conducted and 90 patients were enrolled. A random sequence was generated using statistical analysis software. Patients with microcirculatory injuries after PCI were randomly divided into 3 groups for treatment (30 subjects in each group): Danhong Injection group: after PCI, Danghong Injections were given with intravenous administration with 40 mL twice a day for a week; ...
Source: Chinese Journal of Integrative Medicine - January 12, 2021 Category: Internal Medicine Source Type: research