Wake-Promoting Effect of Bloodletting Puncture at Hand Twelve Jing-Well Points in Acute Stroke Patients: A Multi-center Randomized Controlled Trial
AbstractObjectiveTo assess the effect and safety of bloodletting puncture at hand twelve Jing-Well points (HTWPs) in acute stroke patients with conscious disturbance.MethodsIn this multi-center and randomized controlled trial, 360 patients suffered from ischemic or hemorrhagic stroke with conscious disturbance within 48 h from the onset of symptom were divided into bloodletting (180 cases) and control (180 cases) groups using a block randomization. Patients in both groups received routine Western medicine, and patients in the bloodletting group received additional bloodletting puncture at HTWPs on admission immediately bef...
Source: Chinese Journal of Integrative Medicine - September 11, 2020 Category: Internal Medicine Source Type: research

Pathological Change of Chronic Hepatitis B Patients with Different Tongue Coatings by Circular Multi-Omics Integrated Analysis
AbstractObjectiveTo compare the circular pathological changes of chronic hepatitis B (CHB) patients according to the tongue diagnosis.MethodsTotally 41 CHB patients with typical white tongue coating (WTC) or yellow tongue coating (YTC) were enrolled and 14 healthy volunteers with normal tongue manifestation served as controls. The mRNA expression of peripheral leukocytes was detected by GeneChips, and 9 genes were randomly selected for expression validation. Circular metabolites were detected by gas chromatographymass spectrometry. Biological information was analyzed based on ingenuity pathways analysis or metabolomics dat...
Source: Chinese Journal of Integrative Medicine - September 11, 2020 Category: Internal Medicine Source Type: research

Integrated Chinese and Western Medicine in Treatment of Critical Coronavirus Disease (COVID-19) Patient with Endotracheal Intubation: A Case Report
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 11, 2020 Category: Internal Medicine Source Type: research

Guilu Erxian Glue ( 龟鹿二仙胶) Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16 INK4a -Rb Signaling Pathway
AbstractObjectiveTo evaluate the effect of Guilu Erxian Glue ( 龟鹿二仙胶, GEG) on cyclophosphamide (CTX)-induced bone marrow hematopoietic stem cells (HSCs) senescence in mice and explore the underlying mechanism.MethodsThe H22 liver cancer ascites lump model was established in male Kunming mice by injecting intraperitoneally (i.p.) with 5 × 106/mL H22 cells per mouse. Fifty tumor-bearing mice were divided into the control, model, pifithrin-α, GEG, and GEG+pifithrin-α groups using a random number table, 10 mice in each group. CTX (100 mg/kg i.p.) was administrated to mice from day 1 to day 3 (d1 &nd...
Source: Chinese Journal of Integrative Medicine - September 11, 2020 Category: Internal Medicine Source Type: research

Is There An Advantage of Using Dingkun Pill ( 定坤丹) alone or in Combination with Diane-35 for Management of Polycystic Ovary Syndrome? A Randomized Controlled Trial
AbstractObjectiveTo evaluate the effects of Chinese medicine Dingkun Pill ( 定坤丹) alone or in combination with Diane-35 on patients with polycystic ovary syndrome (PCOS).MethodsThis is a prospective randomized controlled trial conducted at Peking Union Medical College Hospital Beijing, China, from December 2016 to September 2017. Totally 117 PCOS patients were randomly assigned to the Dingkun Pill group (38 cases), Diane-35 group (40 cases), or combined group (39 cases). Patients in the Dingkun Pill group or Diane-35 group took daily 7 g of oral Dingkun Pill or 1 tablet of oral Diane-35, respectively, for 21 consecuti...
Source: Chinese Journal of Integrative Medicine - September 11, 2020 Category: Internal Medicine Source Type: research

Multidisciplinary and Comprehensive Chinese Medicine for Advanced Non-Small Cell Lung Cancer Patients: A Retrospective Study of 855 Cases
AbstractObjectiveTo investigate the effects of multidisciplinary and comprehensive Chinese medicine (CM) treatments on progression-free survival (PFS) and median survival time (MST) in patients with advanced non-small cell lung cancer (NSCLC) and identify factors that influence progression and prognosis.MethodsClinical data of 855 patients with advanced NSCLC who received multidisciplinary and comprehensive CM treatments at Longhua Hospital from January 2009 to December 2018 were retrospectively analyzed. Univariate analysis was performed by the Kaplan-Meier method and log-rank sequential inspection. Multivariate analysis ...
Source: Chinese Journal of Integrative Medicine - September 2, 2020 Category: Internal Medicine Source Type: research

A Bibliometric Analysis and Visualization of Current Research Trends in Chinese Medicine for Osteosarcoma
ConclusionsCompared with other fields, the field of CM treatment for osteosarcome is still in infancy. The distribution of researches is imbalanced and cooperation between countries, institutions and authors remains to be strengthened. Furthermore, basic research occupies an absolute dominant position, and the exploration of the molecular mechanism of CM in preventing and treating OS may become a key point in the future. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 2, 2020 Category: Internal Medicine Source Type: research

Effects of Adjuvant Chinese Patent Medicine Therapy on Prevention of Variceal Rebleeding: A Retrospective Cohort Study
ConclusionAdjuvant CPMs to standard therapy can significantly reduce the incidence of variceal rebleeding and delay the time to rebleeding. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 1, 2020 Category: Internal Medicine Source Type: research

Roles of Gut Microbiota in Pathogenesis of Alzheimer ’s Disease and Therapeutic Effects of Chinese Medicine
AbstractAlzheimer ’s disease (AD) is the most common neurodegenerative disease characterized by progressive cognitive impairment. The pathogenesis of AD is complex, and its susceptibility and development process are affected by age, genetic and epigenetic factors. Recent studies confirmed that gut microbiota (GM) m ight contribute to AD through a variety of pathways including hypothalamic pituitary adrenal axis and inflflammatory and immune processes. CM formula, herbs, and monomer enjoy unique advantages to treat and prevent AD. Hence, the purpose of this review is to outline the roles of GM and its core meta bolite...
Source: Chinese Journal of Integrative Medicine - September 1, 2020 Category: Internal Medicine Source Type: research

Preventive Effects of Qingfei Yihuo Capsules ( 清肺抑火胶囊) on Air Pollution Associated Exacerbation of Chronic Obstructive Pulmonary Disease: A Single-blind, Randomized, Controlled Trial
ConclusionFor patients with Group D COPD, oral QYCs in high-incidence season of air pollution can effectively mitigate respiratory symptoms associated with air pollution, although there was no evidence that it had a significant reductive effect on AEs. (Registered at Chinese Clinical Trial Registry, registration No. ChiCTR-IOR-17013827) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 1, 2020 Category: Internal Medicine Source Type: research

Efficacy of Chinese Medicine Acupoint Application Combined with Montelukast on Children with Perennial Allergic Rhinitis: A Randomized Controlled Trial
AbstractObjectiveTo evaluate the efficacy of Chinese medicine acupoint application (CMAA) combined with Western medicine for perennial allergic rhinitis (PAR) in children.MethodsIn this prospective, parallel, randomized, placebo-controlled and single-blind trial from August to September, 2017, 180 children with PAR were randomly assigned to an integrative group (CMAA and Montelukast), CMAA group (CMAA and placebo tablet), or Montelukast group (placebo CMAA and Montelukast). Participants were applied with CMAA for 6 sessions over 2 weeks, and/or Montelukast Chewable Tablet orally once daily for 12 weeks. The changes in seve...
Source: Chinese Journal of Integrative Medicine - September 1, 2020 Category: Internal Medicine Source Type: research

Emodin Inhibits Lipopolysaccharide-Induced Inflammation by Activating Autophagy in RAW 264.7 Cells
AbstractObjectiveTo investigate the effects of emodin on inflammation and autophagy in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages and reveal its underlying mechanism.Methods3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay was conducted to find the appropriate dose for emodin. RAW264.7 cells pretreated with different concentrations (0 –50 μmol/L) of emodin or vehicle for 2 h prior to exposure to LPS for 16 h. Cell morphology was examined and propidium iodide staining was used to examine cell cycle. Expressions of inflammation-related proteins [nuclear ...
Source: Chinese Journal of Integrative Medicine - August 25, 2020 Category: Internal Medicine Source Type: research

Data Mining Study on Prescription Patterns of Different Dosage Forms of Chinese Herbal Medicines for Treating and Improving Immune-Inflammatory Indices in Patients with Rheumatoid Arthritis
ConclusionsThe principal CHM treatment methods for RA in four hospitals in Anhui Province are strengthening Pi and resolving dampness, activating blood and resolving stasis, dispelling wind/dampness and clearing heat. Granules and decoction pieces of CHMs have similar efficacy in improving immune-inflammatory indices in RA patients and could be used as treatment options for RA. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 22, 2020 Category: Internal Medicine Source Type: research

Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults
ConclusionsThis study demonstrated the effect of proof-of-concept of β-glucan on improving PQD and the proof-of-concept of a multivariate-model-derived diagnostic PQD risk score. It also indicated feasibility for future definitive studies. Studies like this embody an innovative approach that uses therapies derived from the mainstream biomedicine to enrich therapeuti cs guided by CM principle. (Trial registration No. NCT03829228) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 19, 2020 Category: Internal Medicine Source Type: research

Effect of Oral Chinese Medicine Combined with Western Medicine on Cancer Pain: A Meta-Analysis
ConclusionsCompared with the WM, OCM combined with WM could significantly relieve the cancer pain, improve the QOL, decrease the primary time of pain, prolong the analgesic duration time, reduce the dosage of analgesics and side events. The evidence levels were low or very low. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 19, 2020 Category: Internal Medicine Source Type: research

Effectiveness and Safety Evaluation of Chinese Medicine in Treatment of Metastatic Colorectal Cancer after Chemotherapy Failure: Protocol of a Prospective Multicenter Cohort Study
DiscussionThis prospective study will assess the effectiveness and safety of CM in treating metastatic CRC after conventional chemotherapy failure. Patients in the ICM group will be compared with those in the WM group and CM group. If certified to be effective, national provision of CM treatment in metastatic CRC will probably be advised. (Registration No. NCT02923622 on ClinicalTrials.gov) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 19, 2020 Category: Internal Medicine Source Type: research

Epigenetic Landscape Changes Due to Acupuncture Treatment: From Clinical to Basic Research
AbstractAcupuncture has been widely used for treating diseases since the ancient days in China, but the mechanism by which acupuncture exerts such powerful roles is unclear. Epigenetics, including DNA methylation, histone modification, and post-transcriptional regulation of miRNAs, is the study of heritable changes in gene expression that do not include DNA sequence alterations. Epigenetics has become a new strategy for the basic and clinical research of acupuncture in the last decade. Some investigators have been trying to illustrate the mechanism of acupuncture from an epigenetics perspective, which has shed new lights o...
Source: Chinese Journal of Integrative Medicine - August 1, 2020 Category: Internal Medicine Source Type: research

Role of Complementary and Alternative Medicine in Prevention and Treatment of COVID-19: An Overhyped Hope
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 1, 2020 Category: Internal Medicine Source Type: research

Combination of Quercetin, Hirudin and Cinnamaldehyde Promotes Schwann Cell Differentiation and Myelination against High Glucose by Inhibiting ERK Signaling Pathway
AbstractObjectiveTo investigate the therapeutic and synergistic effects of QHC (combination of quercetin (Q), hirudin (H) and cinnamaldehyd (C)) on Schwann cell differentiation and myelination against high glucose (HG) induced injury.MethodsPrimary-culture Schwann cells exposed to HG (50 mmol/L) for 72 h and Schwann cell –dorsal root ganglion (DRG) neuron cocultures exposed to HG (50 mmol/L) for 7 days were employed asin vitro model of diabetic neuropathy. The cells were randomly divided into 10 groups: control (CON, 25 mmol/L glucose), HG (50 mmol/L glucose), HG plus 10 μmol/L quercetin (Q), HG plus 0.04 IU/mL hi...
Source: Chinese Journal of Integrative Medicine - August 1, 2020 Category: Internal Medicine Source Type: research

Efficacy and Safety of Guilingji Capsules ( 龟龄集胶囊) for Treating Mild-to-Moderate Cognitive Impairment: Study Protocol for A Randomized, Double-Blind, Positive-Controlled, Multicenter and Noninferiority Trial
DiscussionThe purpose of this trial is to evaluate the efficacy and safety of GLJC in patients with mild-to-moderate CI with kidney and marrow deficiency syndrome. If successful, the results would provide a viable treatment for patients with mild-to-moderate CI. (Clinical Trials.gov. ID: NCT03647384. Registered on 23 August 2018) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 1, 2020 Category: Internal Medicine Source Type: research

Innovative Modernization and Industrialization of Traditional Chinese Medicine
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 1, 2020 Category: Internal Medicine Source Type: research

Combating Drug Resistance in Colorectal Cancer Using Herbal Medicines
In this study, we reviewed the recent literature which studied potential CRC MDR reversal agents among herbal medicines (HMs). Among abundant HMs, 6 single herbs,Andrographis paniculata, Salvia miltiorrhiza, Hedyotis diffusa, Sophora flavescens, Curcuma longa, Bufo gargarizans, and 2 formulae, Pien Tze Huang and Zhi Zhen Fang, were found to overcome CRC MDR by two or more different mechanisms, which could be a promising candidate in the development of new drugs for adjuvant CRC chemotherapy. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 1, 2020 Category: Internal Medicine Source Type: research

In Silico Screening of Potential Spike Glycoprotein Inhibitors of SARS-CoV-2 with Drug Repurposing Strategy
ConclusionsA class of compounds, which are from FDA-approved drugs and CM natural compounds, that had high binding energy with RBD of the viral spike protein. Our work provides potential candidates for other researchers to identify inhibitors to prevent SARS-CoV-2 infection, and highlights the importance of CM and integrative application of CM and Western medicine on treating COVID-19. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 1, 2020 Category: Internal Medicine Source Type: research

Discussion on Relevance and Studies of Prescription Compatibility in Chinese Medicine
AbstractWith Chinese medicine (CM) gaining popularity in recent years, researchers and clinicians have put in much interest and effort into the makings and effects of it, especially after the recent announcement of World Health Orgnitation ’s incorporation of CM into mainstream medical compendium. Individual herb has complex properties, coming from its pharmacological properties and the Chinese medical principles of organ-directed, taste and dynamic orientational behaviours. The use of individual herb in CM is rare, where various he rbs/ingredients are mostly found in a prescribed formula. To fully reveal the effects...
Source: Chinese Journal of Integrative Medicine - July 27, 2020 Category: Internal Medicine Source Type: research

Effect of Essential Oil of Zhumeria majdae on Morphine Tolerance and Dependence in Mice
ConclusionsZMEO had significant effects on morphine tolerance and dependence. The linalool rich essential oil ofZ. majdae plays a major role in the reduction of tolerance and dependence induced by morphine. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 27, 2020 Category: Internal Medicine Source Type: research

Shenling Baizhu Powder ( 参苓白术散) Ameliorates Pi (Spleen)-Deficiency-Induced Functional Diarrhea in Rats
ConclusionHigh-dose SBP exhibited ameliorating effects against Pi-deficiency induced FD, which might be attributed to its modulations on intestinal absorption function as well as adaptive immunity in mesenteric lymph nodes of rat. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 27, 2020 Category: Internal Medicine Source Type: research

Research Progress in Chinese Medicine Preparations for Promoting Blood Circulation and Removing Blood Stasis for Cirrhotic Patients with Portal Vein Thrombosis Following Splenectomy
This article presented an overview of the therapeutic effects of Chinese medicine (CM) preparations for promoting blood circulation and removing blood stasis for patients with portal vein thrombosis (PVT) after splenectomy. Based on published clinical researches of CM preparations for PVT after splenectomy in patients with cirrhotic portal hypertension (CPH), this paper evaluated the incidence of PVT, and explored potential active components and mechanisms of CM preparations. Safflower Yellow Injection, Danshen Injection ( 丹参注射液) Danhong Injection (丹红注射液), and Compound Danshen Dropping Pill (复方丹...
Source: Chinese Journal of Integrative Medicine - July 20, 2020 Category: Internal Medicine Source Type: research

Shenqi Fuzheng Injection ( 参芪扶正注射液) Combined with Chemotherapy for Acute Leukemia: A Meta-Analysis
AbstractObjectiveTo evaluate to the efficacy and safety of Shenqi Fuzheng Injection ( 参芪扶正注射液, SFI) combined with chemotherapy in the treatment of acute leukemia (AL) by meta-analysis.MethodsPubMed, Cochrane library, Embase, SinoMed, China National Knowledge Infrastructure (CNKI), VIP Journal Integration Platform, Wanfang Database were searched from establishment to November 1, 2018. The randomized controlled trials (RCTs) of SFI combined with chemotherapy in the treatment of AL were included. The Cochrane risk assessment form (RevMan 5.1) was used to evaluate the quality of included studies.ResultsA total of...
Source: Chinese Journal of Integrative Medicine - July 20, 2020 Category: Internal Medicine Source Type: research

Role of Parameter Setting in Electroacupuncture: Current Scenario and Future Prospects
AbstractAcupuncture is an ancient therapeutic method based on the theory of Chinese medicine (CM). Traditional acupuncture has many limitations; it is subjective and relies more on the experience of an acupuncturist, and the efficacy is sometimes irreproducible. In contrast, electroacupuncture (EA) has special characteristics in terms of objectivity and stability, thereby gaining considerable attention. Parameter setting plays a crucial role in EA practice. The current paper summarizes the current situation and limitations of parameter setting in EA practice. Objectification is the tendency and future of CM as well as EA. ...
Source: Chinese Journal of Integrative Medicine - July 20, 2020 Category: Internal Medicine Source Type: research

Exploring an Integrative Therapy for Treating COVID-19: A Randomized Controlled Trial
ConclusionsKeguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients. (Trial registration No. NCT 04251871 atwww.clinicaltrials.gov) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 16, 2020 Category: Internal Medicine Source Type: research

Changes of Anti-tuberculosis Herbs Formula During Past Three Decades in Contrast to Ancient Ones
ConclusionsAlthough there were wide variations in the herb groups and herb combinations in the formulae, half of the top 30 herbs were found in both modern and ancient prescriptions. The core herb combinations in modern and ancient prescriptions could help us to improve the priscription for treatment of TB. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 9, 2020 Category: Internal Medicine Source Type: research

Kang-ai Injection ( 康艾注射液) Inhibits Gastric Cancer Cells Proliferation through IL-6/STAT3 Pathway
AbstractObjectiveTo explore the mechanisms underlying the proliferative inhibition of Chinese herbal medicine Kang-ai injection (KAI, 康艾注射液) in gastric cancer cells.MethodsGastric cancer cell lines MGC803 and BGC823 were treated by 0, 0.3%, 1%, 3% and 10% KAI for 24, 48 and 72 h, respectively. The cell proliferation was evaluated by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay. The apoptosis and cell cycle were evaluated by flow cytometry. Interleukin (IL)-6 mRNA and protein expression levels were detected by quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-li...
Source: Chinese Journal of Integrative Medicine - July 9, 2020 Category: Internal Medicine Source Type: research

Evaluation of Effect of Anthocleista djalonensis A. Chev Root Extract on Testis of Matured Rats
AbstractObjectiveTo investigate the effects of different extracts ofAnthocleista djalonensis on the testis and epididymal sperms of rats.MethodsFifty male Wistar rats were randomly divided into 10 groups (n=5 in each group) and orally treated with 50, 100 and 200 mg/kg body weight each of methanol, aqueous ethanol (H-EtOH) and chloroform extracts ofA. djalonensis. Corn oil was used as vehicle (2 mL/kg). After 60 days of treatment, testosterone (T) and cholesterol (CHOL) concentrations, catalase (CAT), lactate dehydrogenase (LDH), 3 β-hydroxysteroid dehydrogenase (3β-HSD) and superoxide dismutase (SOD) activities ...
Source: Chinese Journal of Integrative Medicine - July 9, 2020 Category: Internal Medicine Source Type: research

Morinda citrifolia (Noni) Juice Suppresses A549 Human Lung Cancer Cells via Inhibiting AKT/Nuclear Factor- κ B Signaling Pathway
ConclusionNoni juice inhibited the proliferation of A549 lung cancer cells, induced apoptosis, and inhibited cell invasion and migration via regulating AKT/NF- κ B signaling pathway. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 9, 2020 Category: Internal Medicine Source Type: research

Danlou Tablet ( 丹蒌片) Improves Chronic Intermittent Hypoxia-induced Dyslipidemia and Arteriosclerosis by HIF-1 α-Angptl4 mRNA Signaling Pathway
AbstractObjectiveTo detect whether Danlou Tablet ( 丹蒌片, DLT) regulates the hypoxia-induced factor (HIF)-1 α-angiopoietin-like 4 (Angptl4) mRNA signaling pathway and explore the role of DLT in treating chronic intermittent hypoxia (CIH)-induced dyslipidemia and arteriosclerosis.MethodsThe mature adipocytes were obtained from 3T3-L1 cell culturation and allocated into 8 groups including control groups (Groups 1 and 5, 0.1 mL of cell culture grade water); DLT groups (Groups 2 and 6, 0.1 mL of 1,000 µg/mL DLT submicron powder solution); dimethyloxalylglycine (DMOG) groups (Groups 3 and 7, DMOG and 0.1 mL of c...
Source: Chinese Journal of Integrative Medicine - July 4, 2020 Category: Internal Medicine Source Type: research

Anti-irritable Bowel Syndrome Syrup Improves Constipation-Predominant Irritable Bowel Syndrome: A Randomized, Placebo-Controlled Trial
ConclusionsAnti-IBS syrup significantly reduced the severity of IBS symptoms compared to placebo. However, there was a need for further investigation regarding the anxiety and depression scores. (Registration No. IRCT2017061034446N1). (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 4, 2020 Category: Internal Medicine Source Type: research

Analysis on Situation of Traditional Chinese Medicine Development and Protection Strategies in China
AbstractWith the worldwide growing interest and commercial value of traditional Chinese medicine (TCM) industries and products, the protection issue of TCM knowledge is increasingly concerned by Chinese government. Here, we investigated the current situation and trend of TCM development and knowledge protection in China through accessing academic research tools including China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP China Science and Technology Journal Database (VIP) and Google Scholar, analyzing the latest data released by National Administration of Traditional Chinese Medicine, China Statistical Yearb...
Source: Chinese Journal of Integrative Medicine - July 4, 2020 Category: Internal Medicine Source Type: research

Focus on Effects of Chinese Medicine on Improving Anxiety-Depression and Quality of Life of Patients with Primary Sj ögren’s Syndrome
AbstractPrimary Sj ögren’s syndrome (pSS) is a chronic autoimmune disease with a long duration of illness, for which there is no cure. Patients often suffer from anxiety and depression due to various reasons, exhibiting a decline in their quality of life. Chinese medicine (CM) has certain advantages in the treatmen t of pSS, which not only helps relieve clinical symptoms and improve treatment outcomes, but also reduces anxiety and depression and improves the quality of life. Therefore, CM should be considered as early as possible given its effectiveness and synergistic effects in treating pSS. (Source: Chinese J...
Source: Chinese Journal of Integrative Medicine - July 1, 2020 Category: Internal Medicine Source Type: research

Mechanism of cAMP-PKA Signaling Pathway Mediated by Shaoyao Gancao Decoction ( 芍药甘草汤) on Regulation of Aquaporin 5 and Muscarinic Receptor 3 Levels in Sjögren’s Syndrome
AbstractObjectiveTo investigate the mechanism of cAMP-PKA signaling pathway mediated by Chinese medicine formula Shaoyao Gancao Decoction ( 芍药甘草汤, SGD) on the regulation of aquaporin 5 (AQP5) and muscarinic receptor 3 (M3R) levels in Sjögren’s syndrome (SS).MethodsOf the 30 mice, 5 were randomly selected as control, and others were used for creating SS model. After successful modeling, mice were randomly divided into 5 groups (n=5 per group) and intragastrically administered with saline (8 mL/kg), pilocarpine (1.4 mg/kg), or low, medium and high doses SGD (0.14, 0.21, 0.35 g/kgRadix paeoniae with 0.01 ...
Source: Chinese Journal of Integrative Medicine - July 1, 2020 Category: Internal Medicine Source Type: research

In Silico Screening of Potential Chinese Herbal Medicine Against COVID-19 by Targeting SARS-CoV-2 3CLpro and Angiotensin Converting Enzyme II Using Molecular Docking
ConclusionThe core drug pair ofForsythiae Fructus-Lonicerae Japonicae Flos containing multiple components and targets is easy to combine with 3CLpro and ACE2, and exerts an anti-COVID-19 pneumonia effect through multi-component and multi-target, and plays the role of anti-COVID-19 pneumonia in multi-pathway. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 1, 2020 Category: Internal Medicine Source Type: research

Tanreqing Injection ( 痰热清注射液) for Patients with Influenza: A Systematic Review and Meta-analysis of Randomized Controlled Trials
AbstractObjectiveTo systematically evaluate the efficacy and safety of Tanreqing Injection ( 痰热清注射液, TRQI) combined with conventional treatment on clinical outcomes in the treatment of patients with influenza.MethodsThe electronic databases searched were Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), MEDLINE (PubMed), EMbase (OvidSP), Chinese Bio-medical Literature and Retrieval System (Sinomed), China National Knowledge Infrastructure Database (CNKI), China Science and Technology Journal Database (VIP) and WanFang Data Knowledge Service Platform, and we checked the reference se...
Source: Chinese Journal of Integrative Medicine - June 22, 2020 Category: Internal Medicine Source Type: research

Exploring Mechanism of Key Chinese Herbal Medicine on Breast Cancer by Data Mining and Network Pharmacology Methods
ConclusionBased on the combination of the data mining method and network pharmacology approach, the therapeutic effect of KCHMs on breast cancer may be realized by acting on target genes and signaling pathways related to the formation and progression of breast cancer. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - June 22, 2020 Category: Internal Medicine Source Type: research

Protective Effects of Salvianolate on Myocardial Injury or Myocardial Infarction after Elective Percutaneous Coronary Intervention in NSTE-ACS Patients: A Randomized Placebo-Controlled Trial
Conclusions: Periprocedural treatment with salvianolate reduces the incidence of PCI related severe myocardial injury or myocardial infarction, although it does not influence clinical prognosis. [Chinese clinical trial registry: ChiCTR1800016992] (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - June 22, 2020 Category: Internal Medicine Source Type: research

Effect of Electro-acupuncture on Expression of IRS-1/PI3K/GLUT4 Pathway in Ovarian Granulosa Cells of Infertile Patients with Polycystic Ovary Syndrome-Insulin Resistance of Phlegm-Dampness Syndrome
AbstractObjectiveTo evaluate the effect of electro-acupuncture (EA) in infertile patients with phlegm-dampness polycystic ovary syndrome-insulin resistance (PCOS-IR).MethodsSeventy-six PCOS-IR patients who underwnetin vitro fertilization and embryo transfer (IVF-ET) were equally assigned to two groups according to a random digital table: the EA group and the control group, with 38 cases in each group. Before undergoing IVF, the two groups were treated with EA or pseudo-acupuncture, respectively, for 3 menstrual cycles. The intervention was 25 min twice a week until the day of oocyte collection. The selected acupoints were ...
Source: Chinese Journal of Integrative Medicine - June 22, 2020 Category: Internal Medicine Source Type: research

Antidepressant-Like Effects of Chaihu Shugan Powder ( 柴胡疏肝散) on Rats Exposed to Chronic Unpredictable Mild Stress through Inhibition of Endoplasmic Reticulum Stress-Induced Apoptosis
AbstractObjectiveTo investigate the antidepressant-like effects of Chaihu Shugan Powder (CSP, 柴胡疏肝散) and to explore its underlying mechanisms.MethodsThirty-two Sprague-Dawley rats were randomly divided into control (CON), chronic unpredictable mild stress (CUMS), fluoxetine (FLU), and CSP groups, 8 rats in each group. All of the rats except for those in the control group were subjected to 3 consecutive weeks of CUMS to establish the depression model. The open field test (OFT), forced swimming test (FST), and sucrose preference test were used to assess the anti-anxiety and antidepressant effects of CSP. Terminal d...
Source: Chinese Journal of Integrative Medicine - June 22, 2020 Category: Internal Medicine Source Type: research

Treatment of HBV Cirrhosis with Fuzheng Huayu Tablet ( 扶正化瘀片) and Entecavir: Design of a Randomized, Double-Blind, Parallel and Multicenter Clinical Trial
DiscussionThrough this study, we hope to generate a solid evidence for the therapeutic strategy of HBV cirrhosis with a combination of anti-viral such as ETV and anti-fibrotic herbal product such as FZHY. Protocol version: Version 1.3, Date: 2014.12.4. Trial registration number: NCT02241590. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - June 22, 2020 Category: Internal Medicine Source Type: research

Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells
AbstractObjectiveTo examine the role of carvacrol in modulating PI3K/AKT signaling involved in human breast cancer pathogenesis usingin vitro experimental model MCF-7 cells.MethodsMTT and lactate dehydrogenase assays were performed with cells treated with different doses of carvacrol (0-250 p mol/L) at different time points (24 and 48 h). The nuclear morphology was assessed in MCF-7 cells with propidium iodide (PI) and acridine orange/ethidium bromide (AO/EB) staining and analyzed by fluorescence microscopy. Events like cell cycle arrest, apoptosis was observed by flow cytometric analysis and expressions of p-Rb, cyclin D1...
Source: Chinese Journal of Integrative Medicine - June 22, 2020 Category: Internal Medicine Source Type: research

Essential Oil from Citrus aurantium Alleviates Anxiety of Patients Undergoing Coronary Angiography: A Single-Blind, Randomized Controlled Trial
ConclusionInhalation of the essential oil fromCitrus aurantium was effective in reducing anxiety and stress levels in patients undergoing coronary angiography. Trial registration: IRCT2016040816797N2 (retrospectively registered on 21 April 2016,https://en.irct.ir/trial/15600) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - June 22, 2020 Category: Internal Medicine Source Type: research

Intestinal Microecology: An Important Target for Chinese Medicine Treatment of Non-alcoholic Fatty Liver Disease
AbstractNon-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases worldwide, causing serious economic and medical burdens. Currently, Chinese medicine (CM) has become an important means in treating NAFLD in China. Intestinal microecology (IM) is an important part of the internal environment in the human body and is involved in the occurrence and development of NAFLD. In this paper, the authors systematically discuss the significance of IM in the pathogenesis of NAFLD and the current status of research on the CM treatment of NAFLD via IM regulation. In combination with our own resear...
Source: Chinese Journal of Integrative Medicine - June 10, 2020 Category: Internal Medicine Source Type: research

Cupping Therapy for Diseases: An Overview of Scientific Evidence from 2009 to 2019
AbstractCupping therapy has been accepted worldwide, and many studies have been conducted to reveal its curative effects and mechanisms. To comprehensively evaluate the effect of cupping therapy, database including China Network Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database VIP, Wan Fang Database, Chinese Biomedicine (CBM), PubMed and Web of Science were searched from 2009 –2019. We summarized all the meta-analyses, randomized controlled trials, clinical trials and the mechanisms studies of cupping therapy in the previous 10 years, hoping to provide a reference for the clinical applications and...
Source: Chinese Journal of Integrative Medicine - June 10, 2020 Category: Internal Medicine Source Type: research