Effectiveness and Safety of Moxibustion Robots on Primary Dysmenorrhea: A Randomized Controlled Pilot Trial
AbstractObjectiveTo conduct a pilot trial to explore the effectiveness and safety of moxibustion robots in treating primary dysmenorrhea (PD) and evaluate its feasibility in clinic.MethodsA total of 70 participants with PD were allocated to either moxibustion robot (MR) group (35 cases) or manual moxibustion (MM) group (35 cases) using computer-generated randomization. One acupoint Guanyuan (CV 4) was selected to receive moxa heat stimulation. Two groups of participants were given 3 menstrual cycles of MM and MR treatment respectively (once a day, 5 days a session) and received another 3 menstrual cycles follow-up. The deg...
Source: Chinese Journal of Integrative Medicine - April 10, 2021 Category: Internal Medicine Source Type: research

Treatment of Chronic Aplastic Anemia with Chinese Patent Medicine Pai-Neng-Da Capsule ( 派能达胶囊) for Replacing Androgen Partially: A Clinical Multi-Center Study
AbstractObjectiveTo evaluate the efficacy and safety of Pai-Neng-Da Capsule ( 派能达胶囊, panaxadiol saponins component, PNDC) in combination with the cyclosporine and androgen for patients with chronic aplastic anemia (CAA).MethodsA total of 79 CAA patients was randomly divided into 2 groups by a random number table, including PCA group [43 cases, orally PNDC 320 mg/d plus cyclosporine 5 mg/(kg ·d) plus andriol 80 mg/d] and CA group [36 cases, orally cyclosporine 5 mg/(kg·d) plus andriol 160 mg/d]. All patients were treated and followed-up for 6 treatment courses over 24 weeks. The complete blood counts...
Source: Chinese Journal of Integrative Medicine - April 10, 2021 Category: Internal Medicine Source Type: research

Protective Effect of Brassica napus L. Hydrosols against Inflammation Response in RAW 264.7 Cells
AbstractObjectiveTo demonstrate the anti-inflammatory activity ofBrassica napus L. hydrosols (BNH) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.MethodsComposition analysis of BNH was conducted via gas chromatography-mass spectrometry after BNH were extracted. The nitric oxide (NO) production was measured using the Griess assay. Prostaglandin E2 (PGE2) production was evaluated with enzyme-linked immunosorbent assay. The effects of BNH on LPS-induced pro-inflammatory enzymes including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were evaluated using Western blot analysis. Furthermore, phospho...
Source: Chinese Journal of Integrative Medicine - March 24, 2021 Category: Internal Medicine Source Type: research

Evidence-Based Immunotherapeutic Effects of Herbal Compounds on Humoral Immunity: Ancient and New Approaches
AbstractThe human immune system represents a dynamic multiscale system with high complexity in biology. Humoral immunity, as the main branch of adaptive immunity, is characterized by differentiated stages of the B lymphocytes, producing the final product of antibodies that has a diversity of the tuning mechanisms within genetic and epigenetic levels in confrontation with environmental exposures. Disorders because of disturbed humoral immunity are linked with dysregulation of feedback-regulated signaling and the dynamic of immune components that determine the overall response. Food products, mainly herbal components have a ...
Source: Chinese Journal of Integrative Medicine - March 24, 2021 Category: Internal Medicine Source Type: research

Effect of High Suspension and Low Incision Surgery Based on Traditional Ligation of Chinese Medicine in Treatment of Mixed Haemorrhoids: A Multi-centre, Randomized, Single-Blind, Non-inferiority Clinical Trial
AbstractObjectiveTo observe the clinical effect of high suspension and low incision (HSLI) surgery on mixed haemorrhoids, compared with Milligan-Morgan haemorrhoidectomy.MethodsA multi-centre, randomized, single-blind, non-inferiority clinical trial was performed. Participants with mixed haemorrhoids from Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing Rectum Hospital, Air Force Medical Center of People ’s Liberation Army of China, and Puyang Hospital of Traditional Chinese Medicine were enrolled from September 2016 to March 2018. By using a blocked randomization scheme, participants were assign...
Source: Chinese Journal of Integrative Medicine - March 12, 2021 Category: Internal Medicine Source Type: research

Electroacupuncture Attenuates Ischemic Brain Injury and Cellular Apoptosis via Mitochondrial Translocation of Cofilin
AbstractObjectiveTo investigate the potential mechanisms of electroacupuncture (EA) to prevent ischemic stroke.MethodsThe method of middle cerebral artery occlusion (MCAO) was employed to establish a rat model of ischemic stroke. Seventy-eight Sprague-Dawley rats were divided into the sham group, MCAO + EA control (EC) group, and MCAO + EA (EA) group according to a random number table (n=26 per group). EA was applied to the acupoints of Baihui (DU 20) and Shenting (DU 24) 5 min and 6 h, respectively after the onset of MCAO. Rats in the sham and EC groups received only light isoflurane anesthesia for 30 min after MCAO. The ...
Source: Chinese Journal of Integrative Medicine - March 12, 2021 Category: Internal Medicine Source Type: research

Chinese Medicine Involving Triple Rehabilitation Therapy ( 中医三联康复疗法) for Knee Osteoarthritis in 696 Outpatients: A Multi-Center, Randomized Controlled Trial
AbstractObjectiveTo determine the effects of Chinese medicine (CM) involving triple rehabilitation therapy ( 中医三联康复疗法) on the progression of knee osteoarthritis (KOA).MethodsA total of 722 patients recruited from 38 community health service centers located in China from March 2013 to March 2017 were randomly divided into treatment and control groups equally, using a cluster randomization design. Health education combined with CM involving triple rehabilitation therapy for KOA (electro-acupuncture, Chinese medicinal herb fumigating-washing, and traditional exercises) was administered in the treatment group w...
Source: Chinese Journal of Integrative Medicine - March 12, 2021 Category: Internal Medicine Source Type: research

Wide Pulse Width Electroacupuncture Ameliorates Denervation-Induced Skeletal Muscle Atrophy in Rats via IGF-1/PI3K/Akt Pathway
ConclusionsEA with 200-ms pulse width was found to have a more significant effect than 0.5-ms EA. The positive effects of EA disappeared after inhibition of the PI3K/Akt pathway. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - March 4, 2021 Category: Internal Medicine Source Type: research

Effect of Acupuncture on Ovary Morphology and Function in DHEA-Induced Polycystic Ovary Syndrome Model Rats
AbstractObjectiveTo investigate the effects of acupuncture on ovary morphology and function in dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) model rats.MethodsA total of 40 adult female Wistar rats were randomly allocated to 4 groups by a random number table, including control, model, metformin and acupuncture groups, 10 rats in each group. PCOS rat model was developed by injecting with DHEA (6 mg/100 g body weight) in 0.2 mL of oil subcutaneously. Electrical stimulation (2 Hz, 3 mA) was applied to Guanyuan (CV 4), Zigong (EX-CA1) and Qihai (CV 6) acupoints for 30 min daily in the acupuncture group...
Source: Chinese Journal of Integrative Medicine - March 1, 2021 Category: Internal Medicine Source Type: research

Therapeutic Effects of Different Animal Bile Powders on Lipid Metabolism Disorders and Their Composition Analysis
AbstractObjectiveTo compare the therapeutic effect of different animal bile powders on lipid metabolism disorders induced by high-fat diet in rats, and analyze the bioactive components of each animal bile powder.MethodsSixty Sprague-Dawley rats were randomly divided into 6 groups (n=10): normal diet control group, high-fat diet model group, high-fat diet groups orally treated with bear, pig, cow and chicken bile powders, respectively. Serum biochemical markers from the abdominal aorta in each group were analyzed. Changes in the body weight and liver weight were recorded. Pathohistological changes in the livers were examine...
Source: Chinese Journal of Integrative Medicine - February 20, 2021 Category: Internal Medicine Source Type: research

Promising Antiviral Molecules from Ayurvedic Herbs and Spices against COVID-19
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - February 5, 2021 Category: Internal Medicine Source Type: research

Effects of Chinese Medicine on Symptoms, Syndrome Evolution, and Lung Inflammation Absorption in COVID-19 Convalescent Patients during 84-Day Follow-up after Hospital Discharge: A Prospective Cohort and Nested Case-Control Study
This study was designed as a prospective cohort and nested case-control study. A total of 96 eligible patients with COVID-19 in convalescence were enrolled from Beijing Youan Hospital and Beijing Huimin Hospital and followed up from the hospital discharged day. Patients were divided into the CM (64 cases) and the control groups (32 cases) based on the treatment with or without CM and followed up at 14, 28, 56, and 84 days after discharge. In the CM group, patients received the 28-day CM treatment according to two types of CM syndrome. Improvements in clinical symptoms, CM syndrome, and absorption of lung inflammation were ...
Source: Chinese Journal of Integrative Medicine - February 3, 2021 Category: Internal Medicine Source Type: research

Thoughts on Traditional Chinese Medicine Treatment of Novel Coronavirus Pneumonia Based on Two Cases
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - February 2, 2021 Category: Internal Medicine Source Type: research

Antitumor Effects of Ethanol Extract from Ventilago leiocarpa Benth on Sarcoma 180 Tumor-Bearing Mice and Possible Immune Mechanism
AbstractObjectiveTo explore the antitumor effects of ethanol extract fromVentilago leiocarpa Benth (EEVLB) on sarcoma 180 (S180) tumor-bearing mice and the potential mechanism.MethodsSixty mice were randomly assigned to 6 groups according to a random number table: normal group, model group, 5-fluorouracil (5-FU) group (0.02 g ·kg−1), and high-, medium-, low-dose EEVLB groups (100, 84, and 56 g of raw material ·kg−1 body weight, respectively), with 10 mice each group. All treatments were given once daily for 10 consecutive days. Effects of EEVLB on inhibiting tumor growth and immune function in mic...
Source: Chinese Journal of Integrative Medicine - January 30, 2021 Category: Internal Medicine Source Type: research

Bloodletting Puncture at Hand Twelve Jing-Well Points Relieves Brain Edema after Severe Traumatic Brain Injury in Rats via Inhibiting MAPK Signaling Pathway
AbstractObjectiveTo investigate whether blood-brain barrier (BBB) served a key role in the edema-relief effect of bloodletting puncture at hand twelve Jing-well points (HTWP) in traumatic brain injury (TBI) and the potential molecular signaling pathways.MethodsAdult male Sprague-Dawley rats were assigned to the sham-operated (sham), TBI, and bloodletting puncture (bloodletting) groups (n=24 per group) using a randomized number table. The TBI model rats were induced by cortical contusion and then bloodletting puncture were performed at HTWP twice a day for 2 days. The neurological function and cerebral edema were evaluated ...
Source: Chinese Journal of Integrative Medicine - January 30, 2021 Category: Internal Medicine Source Type: research

Protective Effects of Hu-Lu-Ba-Wan ( 葫芦巴丸) against Oxidative Stress in Testis of Diabetic Rats through PKCα/NAPDH Oxidase Signaling Pathway
AbstractObjectiveTo explore the protective effect and the underlying mechanism of Hu-Lu-Ba-Wan ( 葫芦巴丸, HLBW) on the testis of diabetic rats.MethodsTwenty-four male Wistar rats (160 –180 g) were randomly divided into 3 groups according to a random number table, including a control group (n=8), diabetic group (n=8), and HLBW group (n=8). Diabetic rat model was established by high-fat-diet administration and single intravenous injection of streptozotocin (26 mg/kg). Then HLBW granule was administrated for 12 weeks. Fasting blood glucose and insulin levels as well as serum total testosterone level and testicular ...
Source: Chinese Journal of Integrative Medicine - January 15, 2021 Category: Internal Medicine Source Type: research

Panax Notoginseng Saponin Attenuates Gastric Mucosal Epithelial Cell Injury Induced by Dual Antiplatelet Drugs through COX and PI3K/Akt/ VEGF-GSK-3 β-RhoA Network Pathway
AbstractObjectiveTo elucidate the underlying mechanism ofPanax notoginseng saponin (PNS) on gastric epithelial cell injury and barrier dysfunction induced by dual antiplatelet (DA).MethodsHuman gastric mucosal epithelial cell (GES-1) was cultured and divided into 4 groups: a control, a DA, a PNS+DA and a LY294002+PNS+DA group. GES-1 apoptosis was detected by flow cytometry, cell permeability were detected using Transwell, level of prostaglandins E2 (PGE2), 6-keto-prostaglandin F1 α (6-keto-PGF1α) and vascular endothelial growth factor (VEGF) in supernatant were measured by enzyme linked immunosorbent assay (ELI...
Source: Chinese Journal of Integrative Medicine - January 15, 2021 Category: Internal Medicine Source Type: research

Homeostasis Research Model Based on Yin-Yang Theory: Five Examples
AbstractIn recent years, the ancient Yin-Yang theory has been gradually adopted by modern researchers, especially European and American scholars, and it has also been applied to modern scientific research on sleep, viruses, metabolism, cancer, genes, autoimmune diseases, and so on. It is very promising and fruitful results have been reported. However, the understanding of the connotations of Yin-Yang theory is not sufficient and thorough enough in these studies. If we understand and apply Yin-Yang theory more comprehensively, it may provide us with additional potential mechanisms and research directions worthy of study. On...
Source: Chinese Journal of Integrative Medicine - January 12, 2021 Category: Internal Medicine Source Type: research

Effect of Danhong Injection ( 丹红注射液) on Improving Coronary Microcirculation Injury after Percutaneous Coronary Intervention
AbstractObjectiveTo explore the effectiveness of Danhong Injection ( 丹红注射液) on improving microcirculatory injury after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD).MethodsA randomized controlled trial was conducted and 90 patients were enrolled. A random sequence was generated using statistical analysis software. Patients with microcirculatory injuries after PCI were randomly divided into 3 groups for treatment (30 subjects in each group): Danhong Injection group: after PCI, Danghong Injections were given with intravenous administration with 40 mL twice a day for a week; ...
Source: Chinese Journal of Integrative Medicine - January 12, 2021 Category: Internal Medicine Source Type: research

Effects of Bushen Yiqi Huoxue Decoction ( 补肾益气活血方) in Treatment of Patients with Diminished Ovarian Reserve: A Randomized Controlled Trial
AbstractObjectiveTo explore the therapeutic effect of Bushen Yiqi Huoxue Decoction ( 补肾益气活血方 BYHD) in patients with diminished ovarian reserve (DOR).MethodsA total of 180 patients with DOR diagnosed from December 2013 to December 2014 were equally assigned into progynova and duphaston (E+D) group, Zuogui Pill ( 左归丸) group and BYHD group with 60 cases in each by computerized randomization. Patients received E+D, Zuogui Pill or BYHD for 12 months, respectively. Follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), anti-M üllerian hormone (AMH), antral follicle count (AFC), ova...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Metabonomics: A Useful Tool to Reveal Underlying Relationships between Altered Chinese Medicine Syndromes and Ultrafiltration in Treatment of Heart Failure
ConclusionsMetabonomic approach is a useful tool to identify potential biomarkers of altered syndromes link to UF and could provide a theoretical basis for further research on the therapeutic mechanism of UF combined with CM. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

DNA Methylation and Transcription of HLA-F and Serum Cytokines Relate to Chinese Medicine Syndrome Classification in Patients with Chronic Hepatitis B
AbstractObjectiveTo explore the molecular bases of Chinese medicine (CM) syndrome classification in chronic hepatitis B (CHB) patients in terms of DNA methylation, transcription and cytokines.MethodsGenome-wide DNA methylation and 48 serum cytokines were detected in CHB patients (DNA methylation: 15 cases; serum cytokines: 62 cases) with different CM syndromes, including dampness and heat of Gan (Liver) and gallbladder (CHB1, DNA methylation: 5 cases, serum cytokines: 15 cases), Gan stagnation and Pi (Spleen) deficiency (CHB2, DNA methylation: 5 cases, serum cytokines: 15 cases), Gan and Shen (Kidney) yin deficiency (CHB3,...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Mechanism of ‘Invigorating Qi and Promoting Blood Circulation’ Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology
ConclusionThe specific mechanism of Ginseng-Danshen drug pair in treating IHD may be associated with improving the changes of metabolites inbody, inhibiting the production of peroxides, removing the endogenous oxygen free radicals, regulating the expression of inflammatory factors, reducing myocardial cell apoptosis and promoting vascular regeneration. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Babao Dan ( 八宝丹) Alleviates 5-Fluorouracil-Induced Intestinal Damage via Wnt/β-Catenin Pathway
AbstractObjectiveTo evaluate the protective function of Babao Dan ( 八宝丹, BBD) on 5-flurouracil (5-FU)-induced intestinal mucositis (IM) and uncover the underlying mechanism.MethodsA total of 18 male mice were randomly divided into 3 groups by a random number table, including control, 5-FU and 5-FU combined BBD groups, 6 mice in each group. A single intraperitoneal injection of 5-FU (150 mg/kg) was performed in 5-FU and 5-FU combined BBD groups on day 0. Mice in 5-FU combined BBD group were gavaged with BBD (250 mg/kg) daily from day 1 to 6. Mice in the control group were gavaged with saline solution for 6 days. The b...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Jiaotai Pill ( 交泰丸) Alleviates Insomnia through Regulating Monoamine and Organic Cation Transporters in Rats
AbstractObjectiveTo reveal the effect and mechanism of Jiaotai Pill JTP) on insomniac rats.MethodsThe insomniac model was established by intraperitoneal injection of p-chlorophenylalanine (PCPA). In behavioral experiments, rats were divided into control, insomniac model, JTP [3.3 g/(kg*d)], and diazepam [4 mg/(kg ·d)] groups. The treatment effect of JTP was evaluated by weight measurement (increasement of body weight), open field test (number of crossings) and forced swimming test (immobility time). A high performance liquid chromatography-electrochemical detection (HPLC-ECD) method was built to determine t he conce...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Ginsenoside Rb1 Protects Human Umbilical Vein Endothelial Cells against High Glucose-Induced Mitochondria-Related Apoptosis through Activating SIRT3 Signalling Pathway
AbstractObjectiveTo investigate whether ginsenoside Rb1 (Rb1) can protect human umbilical vein endothelial cells (HUVECs) against high glucose-induced apoptosis and examine the underlying mechanism.MethodsHUVECs were divided into 5 groups: control group (5.5 mmol/L glucose), high glucose (HG, 40 mmol/L) treatment group, Rb1 (50 µ mol/L) treatment group, Rb1 plus HG treatment group, and Rb1 and 3-(1H-1,2,3-triazol-4-yl) pyridine (3-TYP, 16 µ mol/L) plus HG treatment group. Cell viability was evaluated by cell counting kit-8 assay. Mitochondrial and intracellular reactive oxygen species were detected by MitoSox R...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Effect of Tai Chi and Resistance Training on Cancer-Related Fatigue and Quality of Life in Middle-Aged and Elderly Cancer Patients
AbstractObjectiveTo study the effect of Tai Chi (TC) and resistance training (RT) with different intensity on the cancer-related fatigue (CRF) and quality of life (QoL) of middle-aged and elderly cancer patients.MethodsTotally 120 cancer patients were enrolled and randomly assigned to 4 groups by a random number table, including TC group, high-intensity 60% one repetition maximum (1-RM) RT group (HIRT), low-intensity (30% 1-RM) RT group (LIRT) and control group, 30 patients in each group. Participants in the TC group received 24-form simplified Yang-style TC training at a frequency of 40 min per day, 3 days per week for 12...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Elemene Emulsion Injection Administration Reduces Neuropathic Pain by Inhibiting Astrocytic NDRG2 Expression within Spinal Dorsal Horn
AbstractObjectiveTo investigate the mechanisms underlying elemene-induced analgesia in rats with spared nerve injury (SNI).MethodsSixty-five rats were equally divided into 5 groups using a random number table: naive group, sham group, SNI group, SNI + elemene (40 mg ·kg−1·d−1) group and naive + elemene (40 mg ·kg−1·d−1) group. An SNI rat model was established and the intervention were given respectively for 14 consecutive days. Von Frey filament tests and elevated plus-maze (EPM) tests were used to evaluate the effect of elemene on the mechanical threshold and anxiety, re...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Biological Mechanism of Specific Relationship between Gan (Liver) Meridian of Foot-Jueyin and Genitals
AbstractFrom the perspective view of Chinese medicine, the Gan (Liver) meridian of Foot-Jueyin starts from the great toe, running upward along the medial side of the thigh to the perineal area, where it curves around the external genitalia and goes up to the lower abdomen. In clinical practice, acupoints in the feet of the Gan meridian of Foot-Jueyin are used to treat the genitourinary and external genitalia diseases. Studies have shown that reproductive system diseases have specific pathological reactions in the places (radial side of tibia and foot) where Gan meridian of Foot-Jueyin passes by. Why does this happen? In th...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Effects of Shenfu Injection ( 参附注射液) on Inflammatory Response during Post-Resuscitation Myocardial Dysfunction after Cardiac Arrest in Swine
AbstractObjectiveTo investigate whether Shenfu Injection (SFI, 参附注射液) can alleviate post-resuscitation myocardial dysfunction by inhibiting the inflammatory response.MethodsAfter 8 min of ventricular fibrillation and 2 min of basic life support, 24 pigs were randomly divided into 3 groups (n=8), which were given intravenous bolus injections of SFI (1.0 mL/kg), epinephrine (EP, 0.02 mg/kg) and normal saline (SA), respectively. The animals were sacrificed at 24 h after restoration of spontaneous circulation (ROSC), and serum interleuking-6 (IL-6) and tumor necrosis factor- α (TNF-α) levels were measured...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Chinese Expert Consensus on Clinical Application of Oral Ginkgo biloba Preparations (2020)
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial
AbstractObjectiveTo assess the effect of valerian root extract on the sleep quality of patients after coronary artery bypass graft (CABG) surgery.MethodsThe patients who participated in this triple-blind clinical trial were selected by permuted block randomization. The participants were assigned to the valerian (n=36) and placebo (n=36) groups. The valerian group received 530 mg of valerian capsules for 30 nights after CABG surgery, and the placebo group received 530 mg of the placebo capsules containing wheat flour. The Pittsburgh Sleep Quality Index (PSQI), the prothrombin time (PT) and partial thromboplastin time (PTT) ...
Source: Chinese Journal of Integrative Medicine - January 1, 2021 Category: Internal Medicine Source Type: research

Chinese Medicine in Fighting against Covid-19: Role and Inspiration
AbstractCovid-19 pandemic has caused hundreds of thousands deaths and millions of infections and continued spreading violently. Although researchers are racing to find or develop effective drugs or vaccines, no drugs from modern medical system have been proven effective and the high mutant rates of the virus may lead it resistant to whatever drugs or vaccines developed following modern drug development procedure. Current evidence has demonstrated impressive healing effects of several Chinese medicines (CMs) for Covid-19, which urges us to reflect on the role of CM in the era of modern medicine. Undoubtedly, CM could be pro...
Source: Chinese Journal of Integrative Medicine - January 1, 2021 Category: Internal Medicine Source Type: research

Huoxin Pill ( 活心丸) Attenuates Cardiac Fibrosis by Suppressing TGF-β1/Smad2/3 Pathway in Isoproterenol-Induced Heart Failure Rats
AbstractObjectiveTo evaluate the effects of Huoxin Pill ( 活心丸, HXP) on cardiac fibrosis and heart failure (HF) in isoproterenol (ISO)-induced HF rats.MethodsThirty Wistar rats were randomly divided into 5 groups including control, HF, isosorbide mononitrate (ISMN), HXP low (HXP-L), and HXP high (HXP-H) groups (n=6 for each group) according to the complete randomization method. Rats were pretreated with ISMN (5 mg/kg daily), low concentration of HXP (10 mg/kg daily) or high concentration of HXP (30 mg/kg daily) or equal volume of saline by intragastric administration for 1 week, followed by intraperitoneal injection o...
Source: Chinese Journal of Integrative Medicine - December 22, 2020 Category: Internal Medicine Source Type: research

Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NF κ B Pathway
AbstractObjectiveTo explore whetherPanax notoginseng saponins (PNS) exhibits heart protective effect in myocardial infarction (MI) rats and to identify the potential signaling pathways involved.MethodsMI rats induced by ligating the left anterior descending (LAD) coronary artery were assigned to sham coronary artery ligation or coronary artery ligation. Totally 36 Sprague-Dawley rats were randomly divided into sham group (distilled water,n=9), MI group (distilled water,n=9), PNS group (PNS, 40 mg/kg daily,n=9) and fosinopril group (FIP, 1.2 mg/kg daily,n=9) according to a random number table. The left ventricular morpholog...
Source: Chinese Journal of Integrative Medicine - December 1, 2020 Category: Internal Medicine Source Type: research

Mechanism of Chaihu Shugan Powder ( 柴胡疏肝散) for Treating Depression Based on Network Pharmacology
ConclusionThis article reveals the possible mechanism of CSP in the treatment of depression through network pharmacology research, and lays a foundation for further target studies. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 1, 2020 Category: Internal Medicine Source Type: research

Effect of Anthocleista djalonensis A. Chev Root Extract on Testis of Matured Rats
AbstractObjectiveTo investigate the effects of different extracts ofAnthocleista djalonensis on the testis and epididymal sperms of rats.MethodsFifty male Wistar rats were randomly divided into 10 groups (n=5 in each group) and orally treated with 50, 100 and 200 mg/kg body weight each of methanol, aqueous ethanol (H-EtOH) and chloroform extracts ofA. djalonensis. Corn oil was used as vehicle (2 mL/kg). After 60 days of treatment, testosterone (T) and cholesterol (CHOL) concentrations, catalase (CAT), lactate dehydrogenase (LDH), 3 β-hydroxysteroid dehydrogenase (3β-HSD) and superoxide dismutase (SOD) activities ...
Source: Chinese Journal of Integrative Medicine - December 1, 2020 Category: Internal Medicine Source Type: research

Application Status of Chinese Medicine on Cancer Rehabilitation: A Preliminary Questionnaire Survey
AbstractObjectiveTo investigate the application status of Chinese medicine (CM) in cancer rehabilitation, so as to provide references for improving the level of CM cancer rehabilitation.MethodsA survey questionnaire regarding “application status of CM rehabilitation in cancer patients” for oncologists (doctor version) and cancer patients (patient version) were developed, respectively. From September 2014 to November 2016, a total of 1,000 doctors from oncology department in 48 hospitals and 2,000 cancer patients from CM oncology department from 8 hospitals in China were recruited in this survey. The psychologic...
Source: Chinese Journal of Integrative Medicine - December 1, 2020 Category: Internal Medicine Source Type: research

Chinese Herbal Formula Ermiao Powder ( 二妙散) Regulates Cholinergic Anti-inflammatory Pathway in Rats with Rheumatoid Arthritis
AbstractObjectiveTo investigate the effect of Chinese herbal formula Ermiao Powder ( 二妙散, EMP) on the expression of cholinergic anti-inflammatory pathway in rats with rheumatoid arthritis (RA).MethodsSeventy-two rats were randomly divided into 6 groups according to body weight, including normal control group, collageninduced arthritis (CIA) group, three doses EMP groups, and methotrexate (MTX) group (n=12 per group). All of the rats except for those in the normal control group were given multipoint subcutaneous injection of bovine type II collagen to establish a CIA model. Three EMP groups received a high- (4.5 g/kg)...
Source: Chinese Journal of Integrative Medicine - December 1, 2020 Category: Internal Medicine Source Type: research

Modified Linggui Zhugan Decoction ( 加味苓桂术甘汤) Ameliorates Glycolipid Metabolism and Inflammation via PI3K-Akt/mTOR-S6K1/AMPK-PGC-1 α Signaling Pathways in Obese Type 2 Diabetic Rats
AbstractObjectiveTo investigate the protective effects of modified Linggui Zhugan Decoction ( 加味苓桂术甘汤, MLZD), a traditional Chinese medicine formula, on obese type 2 diabetes mellitus (T2DM) rats.MethodsFifty Sprague-Dawley rats were randomly divided into 5 groups by a random number table, including normal, obese T2DM (ob-T2DM), MLZD low-dose [MLDZ-L, 4.625 g/(kg ·d)], MLZD middle-dose [MLD-M, 9.25 g/(kg·d) ] and MLZD high-dose [MLD-H, 18.5 g/(kg·d)] groups, 10 rats in each group. After 4-week intervention, blood samples and liver, pancreas, muscle tissues were collected to assess the ins...
Source: Chinese Journal of Integrative Medicine - November 19, 2020 Category: Internal Medicine Source Type: research

Comments on “Acupoint Catgut Embedding Alleviates Insomnia in Different Chinese Medicine Syndrome Types: A Randomized Controlled Trial”
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 19, 2020 Category: Internal Medicine Source Type: research

A Bibliometrics Analysis on Academic Influence of Chinese Journal of Integrated Traditional and Western Medicine
ConclusionsAll indicators show that the Journal is a high-quality journal reflecting the excellent achievements in the field of integrated Chinese and Western medicine in China. Through further analysis of relevant indicators, the authors put forward some specific suggestions on how to run the Journal well. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 10, 2020 Category: Internal Medicine Source Type: research

Standard Operating Procedures for Chinese Medicine Data Monitoring Committees of Clinical Studies
AbstractAlthough there is guidance from different regulatory agencies, there are opportunities to bring greater consistency and stronger applicability to address the practical issues of establishing and operating a data monitoring committee (DMC) for clinical studies of Chinese medicine. We names it as a Chinese Medicine Data Monitoring Committee (CMDMC). A panel composed of clinical and statistical experts shared their experience and thoughts on the important aspects of CMDMCs. Subsequently, a community standard on CMDMCs (T/CACM 1323-2019) was issued by the China Association of Chinese Medicine on September 12, 2019. Thi...
Source: Chinese Journal of Integrative Medicine - November 10, 2020 Category: Internal Medicine Source Type: research

Anti-tumor and Phenotypic Regulation Effect of Matrine on Dendritic Cells through Regulating TLRs Pathway
AbstractObjectiveTo investigate the effects of matrine on antigen presentation of dendritic cells (DCs), and to explore the pharmacological mechanism of matrine on anti-tumor effect.MethodsDifferent concentrations (0, 1, 2, 4, 8 and 16 µ g/mL) of matrine were co-cultured with DCs, the harvested DCs were co-cultured with antigens of Lewis lung cancer (LLC) cells, and then DCs and T cells were co-cultured to produce DCs-activated killer (DAK) cells, which have significant tumor-killing activity. The expression of cytokines, mRNA an d protein of toll-like receptors (TLRs) in DCs were detected by enzyme linked immunosobe...
Source: Chinese Journal of Integrative Medicine - November 10, 2020 Category: Internal Medicine Source Type: research

Plant Pharmacophylogeny: Review and Future Directions
AbstractMedicinal plants have provided numerous medicinal active ingredients for thousands of years and these ingredients have been used in Chinese medicine (CM) and traditional pharmacologies worldwide. Recently, the exploitation and utilisation of medicinal plant resources has increased significantly. The results of the studies have led to the identification of many active components, such as steroidal alkaloids, saponins, terpenoids, and glycosides, in various medicinal plants with different evolutionary levels. Moreover, research on the chemical classification, molecular phylogeny, and pharmacological activity of medic...
Source: Chinese Journal of Integrative Medicine - November 10, 2020 Category: Internal Medicine Source Type: research

Initiation of Acupoint Molecular Mechanisms for Manual Acupuncture Analgesia —Nuclear Factor κB Signaling Pathway
AbstractObjectiveTo identify the prominent molecular signaling in acupoints and explore their roles in initiating the analgesia effect of manual acupuncture (MA).MethodA three-step study was conducted, the experiment 1 was a genome-wide analysis of the tissue at acupoint Zusanli (ST 36), including 12 Wistar rats which were divided into control, control+MA1, and control+MA7 groups. In the experiment 2, the paw withdrawal latency (PWL), immunohistochemistry and Western blot analysis of phospho-nuclear factor kappa B (NF κB) p65 (p-p65), phospho-NFκB p50 (p-p50) at ST 36 were performed on rats of saline, saline+MA...
Source: Chinese Journal of Integrative Medicine - November 2, 2020 Category: Internal Medicine Source Type: research

Acupuncture Anesthesia for Radiofrequency Catheter Ablation in Treatment of Persistent Atrial Fibrillation: A Case Report
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 2, 2020 Category: Internal Medicine Source Type: research

Chinese Medicine, Which Targets Body ’s Response State, Is An Effective Way to Treat Epidemic Infectious Diseases
This article discusses the different treatment mechanisms for infectious diseases in CM and modern medicine and the advantages of CM methods, which will reacquaint the world with CM. The improvement of the diagnosis and treatment system of CM based on scientific concepts and methods and the organic combination of both treatment methods of modern medicine and CM will provide the best solution for humans to defeat epidemic infectious diseases. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 10, 2020 Category: Internal Medicine Source Type: research

Efficacy of Getong Tongluo Capsule ( 葛酮通络胶囊) for Convalescent-Phase of Ischemic Stroke and Primary Hypertension: A Multicenter, Randomized, Double-Blind, Controlled Trial
ConclusionGTC exhibited significant efficacy in improving patients ’ quality of life as well as neurological function and controlling hypertension. (Registration No. ChiCTR1800016667) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 10, 2020 Category: Internal Medicine Source Type: research

Integrative Medicine Demonstrates Advantage in COVID-19 Treatment
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 4, 2020 Category: Internal Medicine Source Type: research