Protective Effects of Hu-Lu-Ba-Wan ( 葫芦巴丸) against Oxidative Stress in Testis of Diabetic Rats through PKCα/NAPDH Oxidase Signaling Pathway
AbstractObjectiveTo explore the protective effect and the underlying mechanism of Hu-Lu-Ba-Wan ( 葫芦巴丸, HLBW) on the testis of diabetic rats.MethodsTwenty-four male Wistar rats (160 –180 g) were randomly divided into 3 groups according to a random number table, including a control group (n=8), diabetic group (n=8), and HLBW group (n=8). Diabetic rat model was established by high-fat-diet administration and single intravenous injection of streptozotocin (26 mg/kg). Then HLBW granule was administrated for 12 weeks. Fasting blood glucose and insulin levels as well as serum total testosterone level and testicular ...
Source: Chinese Journal of Integrative Medicine - January 15, 2021 Category: Internal Medicine Source Type: research

Panax Notoginseng Saponin Attenuates Gastric Mucosal Epithelial Cell Injury Induced by Dual Antiplatelet Drugs through COX and PI3K/Akt/ VEGF-GSK-3 β-RhoA Network Pathway
AbstractObjectiveTo elucidate the underlying mechanism ofPanax notoginseng saponin (PNS) on gastric epithelial cell injury and barrier dysfunction induced by dual antiplatelet (DA).MethodsHuman gastric mucosal epithelial cell (GES-1) was cultured and divided into 4 groups: a control, a DA, a PNS+DA and a LY294002+PNS+DA group. GES-1 apoptosis was detected by flow cytometry, cell permeability were detected using Transwell, level of prostaglandins E2 (PGE2), 6-keto-prostaglandin F1 α (6-keto-PGF1α) and vascular endothelial growth factor (VEGF) in supernatant were measured by enzyme linked immunosorbent assay (ELI...
Source: Chinese Journal of Integrative Medicine - January 15, 2021 Category: Internal Medicine Source Type: research

Homeostasis Research Model Based on Yin-Yang Theory: Five Examples
AbstractIn recent years, the ancient Yin-Yang theory has been gradually adopted by modern researchers, especially European and American scholars, and it has also been applied to modern scientific research on sleep, viruses, metabolism, cancer, genes, autoimmune diseases, and so on. It is very promising and fruitful results have been reported. However, the understanding of the connotations of Yin-Yang theory is not sufficient and thorough enough in these studies. If we understand and apply Yin-Yang theory more comprehensively, it may provide us with additional potential mechanisms and research directions worthy of study. On...
Source: Chinese Journal of Integrative Medicine - January 12, 2021 Category: Internal Medicine Source Type: research

Effect of Danhong Injection ( 丹红注射液) on Improving Coronary Microcirculation Injury after Percutaneous Coronary Intervention
AbstractObjectiveTo explore the effectiveness of Danhong Injection ( 丹红注射液) on improving microcirculatory injury after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD).MethodsA randomized controlled trial was conducted and 90 patients were enrolled. A random sequence was generated using statistical analysis software. Patients with microcirculatory injuries after PCI were randomly divided into 3 groups for treatment (30 subjects in each group): Danhong Injection group: after PCI, Danghong Injections were given with intravenous administration with 40 mL twice a day for a week; ...
Source: Chinese Journal of Integrative Medicine - January 12, 2021 Category: Internal Medicine Source Type: research

Effects of Bushen Yiqi Huoxue Decoction ( 补肾益气活血方) in Treatment of Patients with Diminished Ovarian Reserve: A Randomized Controlled Trial
AbstractObjectiveTo explore the therapeutic effect of Bushen Yiqi Huoxue Decoction ( 补肾益气活血方 BYHD) in patients with diminished ovarian reserve (DOR).MethodsA total of 180 patients with DOR diagnosed from December 2013 to December 2014 were equally assigned into progynova and duphaston (E+D) group, Zuogui Pill ( 左归丸) group and BYHD group with 60 cases in each by computerized randomization. Patients received E+D, Zuogui Pill or BYHD for 12 months, respectively. Follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), anti-M üllerian hormone (AMH), antral follicle count (AFC), ova...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Metabonomics: A Useful Tool to Reveal Underlying Relationships between Altered Chinese Medicine Syndromes and Ultrafiltration in Treatment of Heart Failure
ConclusionsMetabonomic approach is a useful tool to identify potential biomarkers of altered syndromes link to UF and could provide a theoretical basis for further research on the therapeutic mechanism of UF combined with CM. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

DNA Methylation and Transcription of HLA-F and Serum Cytokines Relate to Chinese Medicine Syndrome Classification in Patients with Chronic Hepatitis B
AbstractObjectiveTo explore the molecular bases of Chinese medicine (CM) syndrome classification in chronic hepatitis B (CHB) patients in terms of DNA methylation, transcription and cytokines.MethodsGenome-wide DNA methylation and 48 serum cytokines were detected in CHB patients (DNA methylation: 15 cases; serum cytokines: 62 cases) with different CM syndromes, including dampness and heat of Gan (Liver) and gallbladder (CHB1, DNA methylation: 5 cases, serum cytokines: 15 cases), Gan stagnation and Pi (Spleen) deficiency (CHB2, DNA methylation: 5 cases, serum cytokines: 15 cases), Gan and Shen (Kidney) yin deficiency (CHB3,...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Mechanism of ‘Invigorating Qi and Promoting Blood Circulation’ Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology
ConclusionThe specific mechanism of Ginseng-Danshen drug pair in treating IHD may be associated with improving the changes of metabolites inbody, inhibiting the production of peroxides, removing the endogenous oxygen free radicals, regulating the expression of inflammatory factors, reducing myocardial cell apoptosis and promoting vascular regeneration. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Babao Dan ( 八宝丹) Alleviates 5-Fluorouracil-Induced Intestinal Damage via Wnt/β-Catenin Pathway
AbstractObjectiveTo evaluate the protective function of Babao Dan ( 八宝丹, BBD) on 5-flurouracil (5-FU)-induced intestinal mucositis (IM) and uncover the underlying mechanism.MethodsA total of 18 male mice were randomly divided into 3 groups by a random number table, including control, 5-FU and 5-FU combined BBD groups, 6 mice in each group. A single intraperitoneal injection of 5-FU (150 mg/kg) was performed in 5-FU and 5-FU combined BBD groups on day 0. Mice in 5-FU combined BBD group were gavaged with BBD (250 mg/kg) daily from day 1 to 6. Mice in the control group were gavaged with saline solution for 6 days. The b...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Jiaotai Pill ( 交泰丸) Alleviates Insomnia through Regulating Monoamine and Organic Cation Transporters in Rats
AbstractObjectiveTo reveal the effect and mechanism of Jiaotai Pill JTP) on insomniac rats.MethodsThe insomniac model was established by intraperitoneal injection of p-chlorophenylalanine (PCPA). In behavioral experiments, rats were divided into control, insomniac model, JTP [3.3 g/(kg*d)], and diazepam [4 mg/(kg ·d)] groups. The treatment effect of JTP was evaluated by weight measurement (increasement of body weight), open field test (number of crossings) and forced swimming test (immobility time). A high performance liquid chromatography-electrochemical detection (HPLC-ECD) method was built to determine t he conce...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Ginsenoside Rb1 Protects Human Umbilical Vein Endothelial Cells against High Glucose-Induced Mitochondria-Related Apoptosis through Activating SIRT3 Signalling Pathway
AbstractObjectiveTo investigate whether ginsenoside Rb1 (Rb1) can protect human umbilical vein endothelial cells (HUVECs) against high glucose-induced apoptosis and examine the underlying mechanism.MethodsHUVECs were divided into 5 groups: control group (5.5 mmol/L glucose), high glucose (HG, 40 mmol/L) treatment group, Rb1 (50 µ mol/L) treatment group, Rb1 plus HG treatment group, and Rb1 and 3-(1H-1,2,3-triazol-4-yl) pyridine (3-TYP, 16 µ mol/L) plus HG treatment group. Cell viability was evaluated by cell counting kit-8 assay. Mitochondrial and intracellular reactive oxygen species were detected by MitoSox R...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Effect of Tai Chi and Resistance Training on Cancer-Related Fatigue and Quality of Life in Middle-Aged and Elderly Cancer Patients
AbstractObjectiveTo study the effect of Tai Chi (TC) and resistance training (RT) with different intensity on the cancer-related fatigue (CRF) and quality of life (QoL) of middle-aged and elderly cancer patients.MethodsTotally 120 cancer patients were enrolled and randomly assigned to 4 groups by a random number table, including TC group, high-intensity 60% one repetition maximum (1-RM) RT group (HIRT), low-intensity (30% 1-RM) RT group (LIRT) and control group, 30 patients in each group. Participants in the TC group received 24-form simplified Yang-style TC training at a frequency of 40 min per day, 3 days per week for 12...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Elemene Emulsion Injection Administration Reduces Neuropathic Pain by Inhibiting Astrocytic NDRG2 Expression within Spinal Dorsal Horn
AbstractObjectiveTo investigate the mechanisms underlying elemene-induced analgesia in rats with spared nerve injury (SNI).MethodsSixty-five rats were equally divided into 5 groups using a random number table: naive group, sham group, SNI group, SNI + elemene (40 mg ·kg−1·d−1) group and naive + elemene (40 mg ·kg−1·d−1) group. An SNI rat model was established and the intervention were given respectively for 14 consecutive days. Von Frey filament tests and elevated plus-maze (EPM) tests were used to evaluate the effect of elemene on the mechanical threshold and anxiety, re...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Biological Mechanism of Specific Relationship between Gan (Liver) Meridian of Foot-Jueyin and Genitals
AbstractFrom the perspective view of Chinese medicine, the Gan (Liver) meridian of Foot-Jueyin starts from the great toe, running upward along the medial side of the thigh to the perineal area, where it curves around the external genitalia and goes up to the lower abdomen. In clinical practice, acupoints in the feet of the Gan meridian of Foot-Jueyin are used to treat the genitourinary and external genitalia diseases. Studies have shown that reproductive system diseases have specific pathological reactions in the places (radial side of tibia and foot) where Gan meridian of Foot-Jueyin passes by. Why does this happen? In th...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Effects of Shenfu Injection ( 参附注射液) on Inflammatory Response during Post-Resuscitation Myocardial Dysfunction after Cardiac Arrest in Swine
AbstractObjectiveTo investigate whether Shenfu Injection (SFI, 参附注射液) can alleviate post-resuscitation myocardial dysfunction by inhibiting the inflammatory response.MethodsAfter 8 min of ventricular fibrillation and 2 min of basic life support, 24 pigs were randomly divided into 3 groups (n=8), which were given intravenous bolus injections of SFI (1.0 mL/kg), epinephrine (EP, 0.02 mg/kg) and normal saline (SA), respectively. The animals were sacrificed at 24 h after restoration of spontaneous circulation (ROSC), and serum interleuking-6 (IL-6) and tumor necrosis factor- α (TNF-α) levels were measured...
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Chinese Expert Consensus on Clinical Application of Oral Ginkgo biloba Preparations (2020)
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 9, 2021 Category: Internal Medicine Source Type: research

Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial
AbstractObjectiveTo assess the effect of valerian root extract on the sleep quality of patients after coronary artery bypass graft (CABG) surgery.MethodsThe patients who participated in this triple-blind clinical trial were selected by permuted block randomization. The participants were assigned to the valerian (n=36) and placebo (n=36) groups. The valerian group received 530 mg of valerian capsules for 30 nights after CABG surgery, and the placebo group received 530 mg of the placebo capsules containing wheat flour. The Pittsburgh Sleep Quality Index (PSQI), the prothrombin time (PT) and partial thromboplastin time (PTT) ...
Source: Chinese Journal of Integrative Medicine - January 1, 2021 Category: Internal Medicine Source Type: research

Chinese Medicine in Fighting against Covid-19: Role and Inspiration
AbstractCovid-19 pandemic has caused hundreds of thousands deaths and millions of infections and continued spreading violently. Although researchers are racing to find or develop effective drugs or vaccines, no drugs from modern medical system have been proven effective and the high mutant rates of the virus may lead it resistant to whatever drugs or vaccines developed following modern drug development procedure. Current evidence has demonstrated impressive healing effects of several Chinese medicines (CMs) for Covid-19, which urges us to reflect on the role of CM in the era of modern medicine. Undoubtedly, CM could be pro...
Source: Chinese Journal of Integrative Medicine - January 1, 2021 Category: Internal Medicine Source Type: research

Huoxin Pill ( 活心丸) Attenuates Cardiac Fibrosis by Suppressing TGF-β1/Smad2/3 Pathway in Isoproterenol-Induced Heart Failure Rats
AbstractObjectiveTo evaluate the effects of Huoxin Pill ( 活心丸, HXP) on cardiac fibrosis and heart failure (HF) in isoproterenol (ISO)-induced HF rats.MethodsThirty Wistar rats were randomly divided into 5 groups including control, HF, isosorbide mononitrate (ISMN), HXP low (HXP-L), and HXP high (HXP-H) groups (n=6 for each group) according to the complete randomization method. Rats were pretreated with ISMN (5 mg/kg daily), low concentration of HXP (10 mg/kg daily) or high concentration of HXP (30 mg/kg daily) or equal volume of saline by intragastric administration for 1 week, followed by intraperitoneal injection o...
Source: Chinese Journal of Integrative Medicine - December 22, 2020 Category: Internal Medicine Source Type: research

Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NF κ B Pathway
AbstractObjectiveTo explore whetherPanax notoginseng saponins (PNS) exhibits heart protective effect in myocardial infarction (MI) rats and to identify the potential signaling pathways involved.MethodsMI rats induced by ligating the left anterior descending (LAD) coronary artery were assigned to sham coronary artery ligation or coronary artery ligation. Totally 36 Sprague-Dawley rats were randomly divided into sham group (distilled water,n=9), MI group (distilled water,n=9), PNS group (PNS, 40 mg/kg daily,n=9) and fosinopril group (FIP, 1.2 mg/kg daily,n=9) according to a random number table. The left ventricular morpholog...
Source: Chinese Journal of Integrative Medicine - December 1, 2020 Category: Internal Medicine Source Type: research

Mechanism of Chaihu Shugan Powder ( 柴胡疏肝散) for Treating Depression Based on Network Pharmacology
ConclusionThis article reveals the possible mechanism of CSP in the treatment of depression through network pharmacology research, and lays a foundation for further target studies. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 1, 2020 Category: Internal Medicine Source Type: research

Effect of Anthocleista djalonensis A. Chev Root Extract on Testis of Matured Rats
AbstractObjectiveTo investigate the effects of different extracts ofAnthocleista djalonensis on the testis and epididymal sperms of rats.MethodsFifty male Wistar rats were randomly divided into 10 groups (n=5 in each group) and orally treated with 50, 100 and 200 mg/kg body weight each of methanol, aqueous ethanol (H-EtOH) and chloroform extracts ofA. djalonensis. Corn oil was used as vehicle (2 mL/kg). After 60 days of treatment, testosterone (T) and cholesterol (CHOL) concentrations, catalase (CAT), lactate dehydrogenase (LDH), 3 β-hydroxysteroid dehydrogenase (3β-HSD) and superoxide dismutase (SOD) activities ...
Source: Chinese Journal of Integrative Medicine - December 1, 2020 Category: Internal Medicine Source Type: research

Application Status of Chinese Medicine on Cancer Rehabilitation: A Preliminary Questionnaire Survey
AbstractObjectiveTo investigate the application status of Chinese medicine (CM) in cancer rehabilitation, so as to provide references for improving the level of CM cancer rehabilitation.MethodsA survey questionnaire regarding “application status of CM rehabilitation in cancer patients” for oncologists (doctor version) and cancer patients (patient version) were developed, respectively. From September 2014 to November 2016, a total of 1,000 doctors from oncology department in 48 hospitals and 2,000 cancer patients from CM oncology department from 8 hospitals in China were recruited in this survey. The psychologic...
Source: Chinese Journal of Integrative Medicine - December 1, 2020 Category: Internal Medicine Source Type: research

Chinese Herbal Formula Ermiao Powder ( 二妙散) Regulates Cholinergic Anti-inflammatory Pathway in Rats with Rheumatoid Arthritis
AbstractObjectiveTo investigate the effect of Chinese herbal formula Ermiao Powder ( 二妙散, EMP) on the expression of cholinergic anti-inflammatory pathway in rats with rheumatoid arthritis (RA).MethodsSeventy-two rats were randomly divided into 6 groups according to body weight, including normal control group, collageninduced arthritis (CIA) group, three doses EMP groups, and methotrexate (MTX) group (n=12 per group). All of the rats except for those in the normal control group were given multipoint subcutaneous injection of bovine type II collagen to establish a CIA model. Three EMP groups received a high- (4.5 g/kg)...
Source: Chinese Journal of Integrative Medicine - December 1, 2020 Category: Internal Medicine Source Type: research

Modified Linggui Zhugan Decoction ( 加味苓桂术甘汤) Ameliorates Glycolipid Metabolism and Inflammation via PI3K-Akt/mTOR-S6K1/AMPK-PGC-1 α Signaling Pathways in Obese Type 2 Diabetic Rats
AbstractObjectiveTo investigate the protective effects of modified Linggui Zhugan Decoction ( 加味苓桂术甘汤, MLZD), a traditional Chinese medicine formula, on obese type 2 diabetes mellitus (T2DM) rats.MethodsFifty Sprague-Dawley rats were randomly divided into 5 groups by a random number table, including normal, obese T2DM (ob-T2DM), MLZD low-dose [MLDZ-L, 4.625 g/(kg ·d)], MLZD middle-dose [MLD-M, 9.25 g/(kg·d) ] and MLZD high-dose [MLD-H, 18.5 g/(kg·d)] groups, 10 rats in each group. After 4-week intervention, blood samples and liver, pancreas, muscle tissues were collected to assess the ins...
Source: Chinese Journal of Integrative Medicine - November 19, 2020 Category: Internal Medicine Source Type: research

Comments on “Acupoint Catgut Embedding Alleviates Insomnia in Different Chinese Medicine Syndrome Types: A Randomized Controlled Trial”
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 19, 2020 Category: Internal Medicine Source Type: research

A Bibliometrics Analysis on Academic Influence of Chinese Journal of Integrated Traditional and Western Medicine
ConclusionsAll indicators show that the Journal is a high-quality journal reflecting the excellent achievements in the field of integrated Chinese and Western medicine in China. Through further analysis of relevant indicators, the authors put forward some specific suggestions on how to run the Journal well. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 10, 2020 Category: Internal Medicine Source Type: research

Standard Operating Procedures for Chinese Medicine Data Monitoring Committees of Clinical Studies
AbstractAlthough there is guidance from different regulatory agencies, there are opportunities to bring greater consistency and stronger applicability to address the practical issues of establishing and operating a data monitoring committee (DMC) for clinical studies of Chinese medicine. We names it as a Chinese Medicine Data Monitoring Committee (CMDMC). A panel composed of clinical and statistical experts shared their experience and thoughts on the important aspects of CMDMCs. Subsequently, a community standard on CMDMCs (T/CACM 1323-2019) was issued by the China Association of Chinese Medicine on September 12, 2019. Thi...
Source: Chinese Journal of Integrative Medicine - November 10, 2020 Category: Internal Medicine Source Type: research

Anti-tumor and Phenotypic Regulation Effect of Matrine on Dendritic Cells through Regulating TLRs Pathway
AbstractObjectiveTo investigate the effects of matrine on antigen presentation of dendritic cells (DCs), and to explore the pharmacological mechanism of matrine on anti-tumor effect.MethodsDifferent concentrations (0, 1, 2, 4, 8 and 16 µ g/mL) of matrine were co-cultured with DCs, the harvested DCs were co-cultured with antigens of Lewis lung cancer (LLC) cells, and then DCs and T cells were co-cultured to produce DCs-activated killer (DAK) cells, which have significant tumor-killing activity. The expression of cytokines, mRNA an d protein of toll-like receptors (TLRs) in DCs were detected by enzyme linked immunosobe...
Source: Chinese Journal of Integrative Medicine - November 10, 2020 Category: Internal Medicine Source Type: research

Plant Pharmacophylogeny: Review and Future Directions
AbstractMedicinal plants have provided numerous medicinal active ingredients for thousands of years and these ingredients have been used in Chinese medicine (CM) and traditional pharmacologies worldwide. Recently, the exploitation and utilisation of medicinal plant resources has increased significantly. The results of the studies have led to the identification of many active components, such as steroidal alkaloids, saponins, terpenoids, and glycosides, in various medicinal plants with different evolutionary levels. Moreover, research on the chemical classification, molecular phylogeny, and pharmacological activity of medic...
Source: Chinese Journal of Integrative Medicine - November 10, 2020 Category: Internal Medicine Source Type: research

Initiation of Acupoint Molecular Mechanisms for Manual Acupuncture Analgesia —Nuclear Factor κB Signaling Pathway
AbstractObjectiveTo identify the prominent molecular signaling in acupoints and explore their roles in initiating the analgesia effect of manual acupuncture (MA).MethodA three-step study was conducted, the experiment 1 was a genome-wide analysis of the tissue at acupoint Zusanli (ST 36), including 12 Wistar rats which were divided into control, control+MA1, and control+MA7 groups. In the experiment 2, the paw withdrawal latency (PWL), immunohistochemistry and Western blot analysis of phospho-nuclear factor kappa B (NF κB) p65 (p-p65), phospho-NFκB p50 (p-p50) at ST 36 were performed on rats of saline, saline+MA...
Source: Chinese Journal of Integrative Medicine - November 2, 2020 Category: Internal Medicine Source Type: research

Acupuncture Anesthesia for Radiofrequency Catheter Ablation in Treatment of Persistent Atrial Fibrillation: A Case Report
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 2, 2020 Category: Internal Medicine Source Type: research

Chinese Medicine, Which Targets Body ’s Response State, Is An Effective Way to Treat Epidemic Infectious Diseases
This article discusses the different treatment mechanisms for infectious diseases in CM and modern medicine and the advantages of CM methods, which will reacquaint the world with CM. The improvement of the diagnosis and treatment system of CM based on scientific concepts and methods and the organic combination of both treatment methods of modern medicine and CM will provide the best solution for humans to defeat epidemic infectious diseases. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 10, 2020 Category: Internal Medicine Source Type: research

Efficacy of Getong Tongluo Capsule ( 葛酮通络胶囊) for Convalescent-Phase of Ischemic Stroke and Primary Hypertension: A Multicenter, Randomized, Double-Blind, Controlled Trial
ConclusionGTC exhibited significant efficacy in improving patients ’ quality of life as well as neurological function and controlling hypertension. (Registration No. ChiCTR1800016667) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 10, 2020 Category: Internal Medicine Source Type: research

Integrative Medicine Demonstrates Advantage in COVID-19 Treatment
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 4, 2020 Category: Internal Medicine Source Type: research

A Potential Chinese Medicine Granule Suppressing ARDS of COVID-19: Keguan-1
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 4, 2020 Category: Internal Medicine Source Type: research

Clinical Practice Guidelines and Experts ’ Consensuses for Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Chinese Herbal Medicine: A Systematic Review
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 1, 2020 Category: Internal Medicine Source Type: research

Effect and Safety of Tongyan Spray ( 通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke
AbstractObjectiveTo observe the effects and safety of Tongyan Spray ( 通咽喷雾剂) on the range and time of hyoid motion in patients with ischemic post-stroke dysphagia.MethodsSeventy-two patients with ischemic post-stroke dysphagia were selected and randomly assigned to a treatment group (36 cases) and a control group (36 cases) by a random number table from January 2013 to October 2014. All patients swallowed 4 kinds of barium meals with different traits respectively, and each patient underwent video fluoroscopy (VF) examination twice. In the treatment group, Tongyan Spray was sprayed to the pharynx on both sides and...
Source: Chinese Journal of Integrative Medicine - September 29, 2020 Category: Internal Medicine Source Type: research

Hotspot Analysis of Traditional Drugs in Diabetes Treatment Literature
ConclusionsIn this study, we found 7 topics related to the application of traditional drugs in diabetes treatment. The molecular mechanisms of Chinese medicine monomers in diabetes could become a potential hotspot with high centricity and low density. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 29, 2020 Category: Internal Medicine Source Type: research

Electroacupuncture Attenuates Surgical Stress-Induced Reduction of T Lymphocytes through Modulation of Peripheral Opioid System
AbstractObjectiveTo investigate the action mechanisms of electroacupuncture (EA) on postoperative immunosuppression.MethodsMale C57BL/6 mice (5`-7 weeks old) were randomly divided into: the sham injury group, the surgical trauma stressed group, the EA group [surgery + 2/100 Hz EA at Neiguan (PC 6)], and the EA+ Nal (surgery + EA + intraperitoneal injection of naloxone). Abdominal surgical trauma stress mice model was established. EA was performed on bilateral PC 6 acupoints by an EA apparatus (2/100 Hz) for 20 min once a day for 3 days. The mRNA expressions of MOR, DOR, and KOR in thymus and L3`-L5 dorsal root ganglions (D...
Source: Chinese Journal of Integrative Medicine - September 25, 2020 Category: Internal Medicine Source Type: research

Effect of Kangquan Recipe ( 康泉方) on BAMBI Expression in Hypothalamic-Pituitary-Prostate in Rats with Benign Prostatic Hyperplasia
AbstractObjectiveTo investigate the effect of Kangquan Recipe ( 康泉方, KQR) on bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) expression and its mechanism in rats with benign prostatic hyperplasia (BPH).MethodsForty-eight male Sprague-Dawley rats were divided into 6 groups using a random number table, with 8 in each group: the normal group (normal saline 10 mL/kg), the model group (normal saline 10 mL/kg), the finasteride group (0.5 mg/kg), the low-dose KQR group (3.5 g/kg), the middle-dose KQR group (7 g/kg), and the high-dose KQR group (14 g/kg). The 40 rats were subcutaneously injected with ...
Source: Chinese Journal of Integrative Medicine - September 24, 2020 Category: Internal Medicine Source Type: research

Wake-Promoting Effect of Bloodletting Puncture at Hand Twelve Jing-Well Points in Acute Stroke Patients: A Multi-center Randomized Controlled Trial
AbstractObjectiveTo assess the effect and safety of bloodletting puncture at hand twelve Jing-Well points (HTWPs) in acute stroke patients with conscious disturbance.MethodsIn this multi-center and randomized controlled trial, 360 patients suffered from ischemic or hemorrhagic stroke with conscious disturbance within 48 h from the onset of symptom were divided into bloodletting (180 cases) and control (180 cases) groups using a block randomization. Patients in both groups received routine Western medicine, and patients in the bloodletting group received additional bloodletting puncture at HTWPs on admission immediately bef...
Source: Chinese Journal of Integrative Medicine - September 10, 2020 Category: Internal Medicine Source Type: research

Pathological Change of Chronic Hepatitis B Patients with Different Tongue Coatings by Circular Multi-Omics Integrated Analysis
AbstractObjectiveTo compare the circular pathological changes of chronic hepatitis B (CHB) patients according to the tongue diagnosis.MethodsTotally 41 CHB patients with typical white tongue coating (WTC) or yellow tongue coating (YTC) were enrolled and 14 healthy volunteers with normal tongue manifestation served as controls. The mRNA expression of peripheral leukocytes was detected by GeneChips, and 9 genes were randomly selected for expression validation. Circular metabolites were detected by gas chromatographymass spectrometry. Biological information was analyzed based on ingenuity pathways analysis or metabolomics dat...
Source: Chinese Journal of Integrative Medicine - September 10, 2020 Category: Internal Medicine Source Type: research

Integrated Chinese and Western Medicine in Treatment of Critical Coronavirus Disease (COVID-19) Patient with Endotracheal Intubation: A Case Report
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 10, 2020 Category: Internal Medicine Source Type: research

Guilu Erxian Glue ( 龟鹿二仙胶) Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16 INK4a -Rb Signaling Pathway
AbstractObjectiveTo evaluate the effect of Guilu Erxian Glue ( 龟鹿二仙胶, GEG) on cyclophosphamide (CTX)-induced bone marrow hematopoietic stem cells (HSCs) senescence in mice and explore the underlying mechanism.MethodsThe H22 liver cancer ascites lump model was established in male Kunming mice by injecting intraperitoneally (i.p.) with 5 × 106/mL H22 cells per mouse. Fifty tumor-bearing mice were divided into the control, model, pifithrin-α, GEG, and GEG+pifithrin-α groups using a random number table, 10 mice in each group. CTX (100 mg/kg i.p.) was administrated to mice from day 1 to day 3 (d1 &nd...
Source: Chinese Journal of Integrative Medicine - September 10, 2020 Category: Internal Medicine Source Type: research

Is There An Advantage of Using Dingkun Pill ( 定坤丹) alone or in Combination with Diane-35 for Management of Polycystic Ovary Syndrome? A Randomized Controlled Trial
AbstractObjectiveTo evaluate the effects of Chinese medicine Dingkun Pill ( 定坤丹) alone or in combination with Diane-35 on patients with polycystic ovary syndrome (PCOS).MethodsThis is a prospective randomized controlled trial conducted at Peking Union Medical College Hospital Beijing, China, from December 2016 to September 2017. Totally 117 PCOS patients were randomly assigned to the Dingkun Pill group (38 cases), Diane-35 group (40 cases), or combined group (39 cases). Patients in the Dingkun Pill group or Diane-35 group took daily 7 g of oral Dingkun Pill or 1 tablet of oral Diane-35, respectively, for 21 consecuti...
Source: Chinese Journal of Integrative Medicine - September 10, 2020 Category: Internal Medicine Source Type: research

Multidisciplinary and Comprehensive Chinese Medicine for Advanced Non-Small Cell Lung Cancer Patients: A Retrospective Study of 855 Cases
AbstractObjectiveTo investigate the effects of multidisciplinary and comprehensive Chinese medicine (CM) treatments on progression-free survival (PFS) and median survival time (MST) in patients with advanced non-small cell lung cancer (NSCLC) and identify factors that influence progression and prognosis.MethodsClinical data of 855 patients with advanced NSCLC who received multidisciplinary and comprehensive CM treatments at Longhua Hospital from January 2009 to December 2018 were retrospectively analyzed. Univariate analysis was performed by the Kaplan-Meier method and log-rank sequential inspection. Multivariate analysis ...
Source: Chinese Journal of Integrative Medicine - September 1, 2020 Category: Internal Medicine Source Type: research

A Bibliometric Analysis and Visualization of Current Research Trends in Chinese Medicine for Osteosarcoma
ConclusionsCompared with other fields, the field of CM treatment for osteosarcome is still in infancy. The distribution of researches is imbalanced and cooperation between countries, institutions and authors remains to be strengthened. Furthermore, basic research occupies an absolute dominant position, and the exploration of the molecular mechanism of CM in preventing and treating OS may become a key point in the future. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 1, 2020 Category: Internal Medicine Source Type: research

Effects of Adjuvant Chinese Patent Medicine Therapy on Prevention of Variceal Rebleeding: A Retrospective Cohort Study
ConclusionAdjuvant CPMs to standard therapy can significantly reduce the incidence of variceal rebleeding and delay the time to rebleeding. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 31, 2020 Category: Internal Medicine Source Type: research

Roles of Gut Microbiota in Pathogenesis of Alzheimer ’s Disease and Therapeutic Effects of Chinese Medicine
AbstractAlzheimer ’s disease (AD) is the most common neurodegenerative disease characterized by progressive cognitive impairment. The pathogenesis of AD is complex, and its susceptibility and development process are affected by age, genetic and epigenetic factors. Recent studies confirmed that gut microbiota (GM) m ight contribute to AD through a variety of pathways including hypothalamic pituitary adrenal axis and inflflammatory and immune processes. CM formula, herbs, and monomer enjoy unique advantages to treat and prevent AD. Hence, the purpose of this review is to outline the roles of GM and its core meta bolite...
Source: Chinese Journal of Integrative Medicine - August 31, 2020 Category: Internal Medicine Source Type: research