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Wuzi Yanzong Pill Plays A Neuroprotective Role in Parkinson ’s Disease Mice via Regulating Unfolded Protein Response Mediated by Endoplasmic Reticulum Stress
ConclusionsWYP ameliorated motor symptoms and pathological lesion of PD mice, which may be related to the regulation of unfolded protein response-mediated signaling pathway and inhibiting the endoplasmic reticulum stress-mediated neuronal apoptosis pathway. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 12, 2022 Category: Internal Medicine Source Type: research

LOX-1 Regulation in Anti-atherosclerosis of Active Compounds of Herbal Medicine: Current Knowledge and the New Insight
AbstractLectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) have recently been identified to be closely related to the occurrence and development of atherosclerosis (AS). A growing body of evidence has suggested Chinese medicine takes unique advantages in preventing and treating AS. In this review, the related research progress of AS and LOX-1 has been summarized. And the anti-AS effects of 10 active components of herbal medicine through LOX-1 regulation have been further reviewed. As a potential biomarker and target for intervention in AS, LOX-1 targeted therapy might provide a promising and novel approach to ...
Source: Chinese Journal of Integrative Medicine - November 7, 2022 Category: Internal Medicine Source Type: research

Effect of Auricular Acupoint Bloodletting plus Auricular Acupressure on Sleep Quality and Neuroendocrine Level in College Students with Primary Insomnia: A Randomized Controlled Trial
ConclusionsBoth AB+AA and AA can relieve insomnia symptoms, but a stronger long-term effect were observed for AB+AA. AB+AA can promote the secretion of MT, increase the levels of Glu and GABA more effective than AA, and regulate their imbalance, and thus it may be benificial for treating insomnia. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 3, 2022 Category: Internal Medicine Source Type: research

Suxiao Jiuxin Pills Prevent Ventricular Fibrillation from Inhibiting L-type Calcium Currents CaV1.2 in vivo and in vitro
ConclusionSJP reduced VF via inhibiting the CaV1.2 current within vivo, in vitro, andin silico studies, which provide experimental basis for SJP anti-VF clinical application. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 3, 2022 Category: Internal Medicine Source Type: research

Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats
ConclusionKT could protect blood pressure of Ang II-induced OVX rats by inhibiting oxidative stress and up-regulating protective autophagy. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 3, 2022 Category: Internal Medicine Source Type: research

Chinese Medicine as Supporting Therapy for Psoriasis: Past, Present, and Future
AbstractPsoriasis is a chronic skin disease and an important health concern. Western medicine and therapies are the main treatment strategies for psoriasis vulgaris (PV); however, the overall prognosis of patients with PV is still poor. Therefore, PV prevention is especially crucial. Chinese medicine (CM) has a long history of treating psoriasis, and it has unique wisdom in different cognitive angles and treatment modes from modern medicine. In this review, we first summarized the herbs and ancient CM formulas that have therapeutic effects on PV. Second, the research status and obstacles to the current development of CM in...
Source: Chinese Journal of Integrative Medicine - October 27, 2022 Category: Internal Medicine Source Type: research

Guanxin Danshen Dripping Pills Improves Quality of Life and Cardiovascular Prognoses of Patients with CHD after PCI Complicated with Depression or Anxiety (GLAD Study): A Randomized Double-Blind Placebo-Controlled Study
ConclusionsGXDS can significantly alleviate depression and anxiety, relieve symptoms of angina, and improve quality of life in patients with CHD after PCI. (Registration No. ChiCTR1800014291) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 27, 2022 Category: Internal Medicine Source Type: research

Efficacy and Safety of Jianpi Jieyu Decoction for Patients with Mild-to-Moderate Depression of Xin (Heart)-Pi (Spleen) Deficiency Syndrome: A Multi-centre Randomized Controlled Study
ConclusionCompared with paroxetine, JJD was associated with a significantly lower incidence of AEs in patients with mild-to-moderate depression of XPD syndrome, with no difference in efficacy at 6 weeks. (Trial registration No. ChiCTR2000040922) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 27, 2022 Category: Internal Medicine Source Type: research

Qishen Yiqi Dripping Pills for Cardiovascular Diseases: Effects and Mechanisms
AbstractQishen Yiqi Dripping Pills (QSYQ) is a compound of Chinese medicine, which has been used to treat coronary heart disease and cardiac dysfunction. Its natural components include astragaloside IV, flavonoids, danshensu, protocatechualdehyde, salvianolic acid B, salvianolic acid A, ginsenosides Rg1, ginsenosides Rb1, and essential oils, etc. It exerts effects of nourishing qi and promoting blood circulation to relieve pain. In this review, the bioactive components of QSYQ and its effects for treating cardiovascular diseases and possible mechanism were summarized, providing references for further study and clinical app...
Source: Chinese Journal of Integrative Medicine - October 27, 2022 Category: Internal Medicine Source Type: research

Babao Dan Alleviates 5-Fluorouracil-Induced Intestinal Damage via Wnt/ β-Catenin Pathway
ConclusionsBBD attenuates the adverse effects induced by 5-FU via Wnt/ β-catenin pathway, suggesting it may act as a potential agent against chemotherapy-induced intestinal mucositis. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 24, 2022 Category: Internal Medicine Source Type: research

Analgesic Activity of Jin Ling Zi Powder and Its Single Herbs: A Serum Metabonomics Study
ConclusionsThe analgesic mechanism of JLZ and YHS was mainly due to the combination of glycine and its receptor, producing post-synaptic potential, reducing the excitability of neurons, and weakening the afferent effect of painful information. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 24, 2022 Category: Internal Medicine Source Type: research

Lizhong Decoction Ameliorates Ulcerative Colitis in Mice via Regulation of Plasma and Urine Metabolic Profiling
ConclusionsThe study revealed the underlying mechanism of LZD on amelioration of ulcerative colitis based on metabonomics, which laid a foundation for further exploring the pathological and physiological mechanism, early diagnosis, and corresponding drug development of colitis. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 24, 2022 Category: Internal Medicine Source Type: research

Integration of Gut Microbiota and Metabolomics for Chinese Medicine Research: Opportunities and Challenges
AbstractChinese medicines (CM) are gaining more attentions from all over the world. However, there are a large body of questions to be answered because of the chemical complexity of CM and intricate molecular reactions within human body. In recent years, gut microbiota and metabolomics have emerged as two cynosures in deciphering the mechanisms of how our body is functioning. Since gut microbiota and host is a closely interrelated system, paying attention only to gut microbiota or metabolites may omit the interplays among CM, gut microbiota, and hosts. To systemically study these interplays, a network understanding of CM c...
Source: Chinese Journal of Integrative Medicine - October 24, 2022 Category: Internal Medicine Source Type: research

Naoxintong Capsule for Secondary Prevention of Ischemic Stroke: A Multicenter, Randomized, and Placebo-Controlled Trial
ConclusionThe combination of Naoxintong Capsule with standard care reduced the 2-year stroke recurrence rate in patients with ischemic stroke without increasing the risk of severe hemorrhage in high-risk patients. (Trial registration No. NCT02334969) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 17, 2022 Category: Internal Medicine Source Type: research

Mechanism of Gentisic Acid on Rheumatoid Arthritis Based on miR-19b-3p/RAF1 Axis
ConclusionGA regulated miR-19b-3p/RAF1 axis to mediate ERK pathway and inhibit the development of RA. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 17, 2022 Category: Internal Medicine Source Type: research