Sanhuang Xiexin Decoction Ameliorates TNBC By Modulating JAK2-STAT3 and Lipid Metabolism
ConclusionSXD could inhibit TNBC by suppressing JAK2-STAT3 phosphorylation which may be associated with modulation of lipid metabolism. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 6, 2023 Category: Internal Medicine Source Type: research

Critical Review on Balanites aegyptiaca Delile: Phytoconstituents, Pharmacological Properties and Nanointerventions
AbstractBalanites aegyptiaca Delile (BA) is an enduring xerophytic woody and spinous flowering tree and is commonly known as desert date or Ingudi (Hingot). It belongs to the familyZygophyllaceae, which is specific to be drought areas of Nigeria, Africa, South Asia and India (Rajasthan). In Ayurveda, this traditional medicinal plant is reported for the management of jaundice, syphilis, yellow fever, metabolic disorders, liver, and spleen problems. The main aim of the review is to compile its medicinal uses and further advancements to showcase the promises inherited in various parts of the plant for the benefit of mankind.A...
Source: Chinese Journal of Integrative Medicine - November 6, 2023 Category: Internal Medicine Source Type: research

TRAIL and Celastrol Combinational Treatment Suppresses Proliferation, Migration, and Invasion of Human Glioblastoma Cells via Targeting Wnt/ β-catenin Signaling Pathway
ConclusionsCelastrol and TRAIL can synergistically suppress glioblastoma cell migration, invasion, and EMT, potentially through inhibition of Wnt/ β-catenin pathway. This underlies a novel mechanism of action for TCCT as an effective therapy for glioblastoma. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 20, 2023 Category: Internal Medicine Source Type: research

Rheum palmatum L. and Salvia miltiorrhiza Bge. Alleviates Acute Pancreatitis by Regulating Th17 Cell Differentiation: An Integrated Network Pharmacology Analysis, Molecular Dynamics Simulation and Experimental Validation
ConclusionDH-DS could inhibit the expression of inflammatory factors and protect pancreatic tissues, which would be functioned by regulating Th17 cell differentiation-related mRNA and protein expressions. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 20, 2023 Category: Internal Medicine Source Type: research

Mechanism Exploration of Euphorbia fischeriana Steud. for Liver Cancer Based on Aspartic Acid Identification in Metabolomics
ConclusionThe anti-liver cancer efficacy of LD extract was validated in H22 mice model, and inhibition of Asp level might be the underlying mechanism. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 20, 2023 Category: Internal Medicine Source Type: research

Elemene Antitumor Drugs Development Based on “Molecular Compatibility Theory” and Clinical Application: A Retrospective and Prospective Outlook
AbstractElemene, derived fromCurcuma wenyujin, one of the “8 famous genuine medicinal materials of Zhejiang province,” exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian, introduced the innovative concept of “molecular compatibility theory” by combining Chinese medic ine principles, specifically the “monarch, minister, assistant, and envoy” theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene...
Source: Chinese Journal of Integrative Medicine - October 14, 2023 Category: Internal Medicine Source Type: research

Fangji Fuling Decoction Alleviates Sepsis by Blocking MAPK14/FOXO3A Signaling Pathway
ConclusionFFD could ameliorate the LPS-induced inflammatory response in septic mice by inhibiting the MAPK14/FOXO3A signaling pathway. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 10, 2023 Category: Internal Medicine Source Type: research

Pregnancy Benefit of Acupuncture on in vitro Fertilization: A Systematic Review and Meta-Analysis
ConclusionResults showed that the convincing evidence levels on the associations between acupuncture and IVF pregnant outcomes were relatively low, and the varied methodological design and heterogeneity might inflfluence the fifindings. (Registration No. PROSPERO CRD42021232430) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 10, 2023 Category: Internal Medicine Source Type: research

Curcumin Interferes with TGF- β 1-Induced Fibrosis in NRK-49F Cells by Reversing ADAMTS18 Gene Methylation
ConclusionTGF- β 1-induced fibrosis in NRK-49F cells. Curcumin promoted ADAMTS18 expression, reduced ECM accumulation, and alleviated RIF progression by inhibiting ADAMTS18 methylation. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 27, 2023 Category: Internal Medicine Source Type: research

Challenges and Opportunities in the Practice of Chinese Medicine in Singapore
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 26, 2023 Category: Internal Medicine Source Type: research

Monotropein Induced Apoptosis and Suppressed Cell Cycle Progression in Colorectal Cancer Cells
ConclusionMonotropein exerts its antitumor effects primarily by arresting the cell cycle, causing cell apoptosis, and inhibiting cell migration. This indicates a high potential for developing novel medication for treating CRC. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 26, 2023 Category: Internal Medicine Source Type: research

Pharmacological Effects of Botanical Drugs on Myocardial Metabolism in Chronic Heart Failure
AbstractAlthough there have been significant advances in the treatment of heart failure in recent years, chronic heart failure remains a leading cause of cardiovascular disease-related death. Many studies have found that targeted cardiac metabolic remodeling has good potential for the treatment of heart failure. However, most of the drugs that increase cardiac energy are still in the theoretical or testing stage. Some research has found that botanical drugs not only increase myocardial energy metabolism through multiple targets but also have the potential to restore the balance of myocardial substrate metabolism. In this r...
Source: Chinese Journal of Integrative Medicine - September 26, 2023 Category: Internal Medicine Source Type: research

Advances in Phytochemistry and Modern Pharmacology of Saposhnikovia Divaricata (Turcz.) Schischk
AbstractSaposhnikovia divaricata (Turcz.) Schischk (S. divaricata, Fangfeng) is a herb in theApiaceae family, and its root has been used since the Western Han Dynasty (202 B.C.). Chromones and coumarins are the pharmacologically active substances inS. divaricata. Modern phytochemical and pharmacological studies have demonstrated their antipyretic, analgesic, anti-inflammatory, antioxidant, anti-tumor, and anticoagulant activities. Technological and analytical strategy theory advancements have yielded novel results; however, most investigations have been limited to the main active substances —chromones and coumarins. Henc...
Source: Chinese Journal of Integrative Medicine - September 21, 2023 Category: Internal Medicine Source Type: research

Benefit-Risk Assessment of Chinese Medicine Injections for Primary Liver Cancer Based on Multi-criteria Decision Analysis
ConclusionBased on the results of MCDA model, CINI combined with TACE has the greatest risk in the treatment of the PLC. Considering the efficacy and safety, the possible priority of the 3 Chinese medicine injections combined with TACE in the treatment of PLC is ADI, CKI and CINI. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 12, 2023 Category: Internal Medicine Source Type: research

Lemon Myrtle (Backhousia citriodora): An Alternative and Effective Treatment for Molluscum Contagiosum in Children with Atopic Dermatitis
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 11, 2023 Category: Internal Medicine Source Type: research