Knowledge Graph Enhanced Transformers for Diagnosis Generation of Chinese Medicine
In conclusion, text generation technology can be effectively applied to CM diagnostic modeling. It can effectively avoid the problem of poor diagnostic performance caused by excessiv e and similar categories in traditional CM diagnostic classification models. CM diagnostic text generation technology has broad application prospects in the future. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 15, 2024 Category: Internal Medicine Source Type: research

Pien Tze Huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway
ConclusionThe mechanism by which PZH induces its CRC anti-proliferative effect is at least in part by regulating the expression of PNO1 and its downstream targets p53 and p21. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 13, 2024 Category: Internal Medicine Source Type: research

Chemical Composition, Pharmacological Effects and Clinical Applications of Cinobufacini
AbstractChinese medicine cinobufacini is an extract from the dried skin ofBufo bufo gargarizans Cantor, with active ingredients of bufadienolides and indole alkaloids. With further research and clinical applications, it is found that cinobufacini alone or in combination with other therapeutic methods can play an anti-tumor role by controlling proliferation of tumor cells, promoting apoptosis, inhibiting formation of tumor neovascularization, reversing multidrug resistance, and regulating immune response; it also has the functions of relieving cancer pain and regulating immune function. In this paper, the chemical compositi...
Source: Chinese Journal of Integrative Medicine - January 12, 2024 Category: Internal Medicine Source Type: research

Factors and Their Impact on Treatment Effect of Acupuncture in Different Outcomes: A Meta-Regression of Acupuncture Randomized Controlled Trials
ConclusionsHigh-frequency acupuncture sessions appear to be a more effective approach to managing painful symptoms. Penetrating acupuncture demonstrated greater effect in relieving non-painful symptoms. Both penetrating acupuncture type and flexible acupuncture regimen were linked to significant treatment effects in function outcomes. Future studies should consider the factors that are significantly associated with the effects of acupuncture in patient-important outcomes. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 12, 2024 Category: Internal Medicine Source Type: research

Radix Sanguisorbae Improves Intestinal Barrier in Septic Rats via HIF-1 α/HO-1/Fe2+ Axis
ConclusionRS improved the intestinal barrier function and alleviated intestinal injury by inhibiting ferroptosis, which was related in part to HIF-1 α/heme oxygenase-1/Fe2+ axis. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 12, 2024 Category: Internal Medicine Source Type: research

Chinese Medicine Combined with Adjuvant Chemotherapy for Improving Myelosuppression in Colorectal Cancer Patients: A Systematic Review and Network Meta-Analysis
ConclusionsThis NMA provided evidence to support that patients with CRC benefit from receiving different combination of CHM chemotherapies. Among these, GL plus chemotherapy and BZD plus chemotherapy were the more effective for myelosuppression in patients; however, as the qualtiy of evidence is insufficient, further research is needed. (PROSPERO, No. CRD42022369025) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 12, 2024 Category: Internal Medicine Source Type: research

Different Acupuncture Therapies for Postherpetic Neuralgia: An Overview of Systematic Reviews and Meta-analysis
ConclusionsAcupuncture therapy seems to be effective in treating PHN. Despite the evidence that suggested the advantages of acupuncture therapy in relieving pain and promoting efficacy and safety, the methodological quality was quite low. Further studies should pay more attention to the quality of original studies and evidence for SRs to confirm these findings. (PROSPERO registration No. CRD42022344790) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 12, 2024 Category: Internal Medicine Source Type: research

Immunomodulatory Function of Pien Tze Huang in T Cell-Mediated Anti-tumor Activity against B16 –F10, MC38 and Hep1-6 Tumor Models
ConclusionThis study has confirmed a novel immunomodulatory function of PZH in T cell-mediated anti-tumor immunity, indicating that PZH holds promise as a potential therapeutic agent for cancer treatment. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 12, 2024 Category: Internal Medicine Source Type: research

Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway
ConclusionIsorhamnetin exhibited anti-RA effects through modulating SRC/ERK/CREB and MMP2/MMP9 signaling pathways, suggesting that isorhamnetin may be a potential therapeutic agent for RA. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 12, 2024 Category: Internal Medicine Source Type: research

Modified Sijunzi Granules Exhibit Hemostatic Effect by Activating Akt and Erk Signal Pathways via Regulating 5-HT and Its Receptors Levels
ConclusionsMSG could reduce the incidence and severity of intestinal bleeding in zebrafish by activating MAPK/Erk and PI3K/Akt signal pathways through regulating the levels of 5-HT and its receptors, which may provide evidence for the treatment of ITP. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 12, 2024 Category: Internal Medicine Source Type: research

Electroacupuncture Promotes Functional Recovery after Facial Nerve Injury in Rats by Regulating Autophagy via GDNF and PI3K/mTOR Signaling Pathway
ConclusionsEA could promote the recovery of facial function and repair the facial nerve damages in a rat model of FNI. EA may exert this neuroreparative effect through mediating the release of GDNF, activating the PI3K/mTOR signaling pathway, and further regulating the autophagy of facial nerves. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 12, 2024 Category: Internal Medicine Source Type: research

A Dietary Supplement Jinghuosu Ameliorates Reproductive Damage Induced by Tripterygium Glycosides
ConclusionDS Jinghuosu protects against TG-induced reproductive system injury in rats, probably by improving zinc homeostasis, enhancing the testosterone synthesis and attenuating oxidative stress. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 12, 2024 Category: Internal Medicine Source Type: research

Disease-Related Factors Associated with Acupuncture Response in Patients with Chronic Tension-Type Headache: A Secondary Analysis of A Randomized Controlled Trial
ConclusionsGreater headache intensity, lower GH score, and higher SF score were associated with better acupuncture responses in CTTH patients. These 3 factors require independent validation as predictors of acupuncture effectiveness in CTTH. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 11, 2024 Category: Internal Medicine Source Type: research

Integrated Chinese and Western Medicine in Treatment of Bronchopleural Fistula with Mycobacterium abscessus: A Case Report
(Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 29, 2023 Category: Internal Medicine Source Type: research

Protective Effects of Phellodendron Species on Bone Health: A Novel Perspective on Their Potentials in Treating Osteoporosis and Osteoarthritis
AbstractPhellodendron (PN) species, traditionally used in Chinese medicine for centuries, hold promise as a potential treatment for osteoporosis (OP) and osteoarthritis (OA) due to their bioactive compounds. The bioactive compounds, including berberine and palmatine, exhibit anti-inflammatory, antioxidant, and bone-protective properties, contributing to their potential therapeutic benefits in promoting bone health and preventing bone loss. However, challenges such as the need for standardized preparation and dosing, limited clinical studies, and potential interactions with other medications hinder their clinical use. Nonet...
Source: Chinese Journal of Integrative Medicine - December 29, 2023 Category: Internal Medicine Source Type: research