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Bloodletting Acupuncture at Jing-Well Points Alleviates Myocardial Injury in Acute Altitude Hypoxic Rats by Activating HIF-1 α/BNIP3 Signaling-Mediated Mitochondrial Autophagy and Decreasing Oxidative Stress
ConclusionBAJP is an effective treatment for AHH-induced myocardial injury, and the mechanism might involve increasing HIF-1 α/BNIP3 signaling-mediated autophagy and decreasing oxidative stress. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 9, 2022 Category: Internal Medicine Source Type: research

Curcumin Inhibits Proliferation of Renal Cell Carcinoma in vitro and in vivo by Regulating miR-148/ADAMTS18 through Suppressing Autophagy
ConclusionCurcumin can inhibit the proliferation of renal cell carcinoma by regulating the miR-148/ ADAMTS18 axis through the suppression of autophagyin vitro andin vivo. There may exist a positive feedback loop between miR-148 and ADAMTS18 gene in RCC. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 7, 2022 Category: Internal Medicine Source Type: research

Therapeutic Mechanism of Kai Xin San on Alzheimer ’s Disease Based on Network Pharmacology and Experimental Validation
ConclusionKXS exerted neuroprotective effects by regulating the A β -GSK3β-Tau signaling pathway, which provides novel insights into the therapeutic mechanism of KXS and a feasible pharmacological strategy for the treatment of AD. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 7, 2022 Category: Internal Medicine Source Type: research

Dihydromyricetin Alleviates H9C2 Cell Apoptosis and Autophagy by Regulating CircHIPK3 Expression and PI3K/AKT/mTOR Pathway
ConclusionDmy plays a protective role in H9C2 cells by inhibiting circHIPK expression and cell apoptosis and autophagy, and the mechanism may be related to PI3K/AKT/mTOR pathway. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 7, 2022 Category: Internal Medicine Source Type: research

Effect of Shengmai Yin on Epithelial-Mesenchymal Transition of Nasopharyngeal Carcinoma Radioresistant Cells
ConclusionsSMY can reverse the EMT process of CNE-2R cells, which may be related to its inhibition of LCN2 expression. Therefore, LCN2 may be a potential diagnostic marker and therapeutic target in patients with NPC. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 7, 2022 Category: Internal Medicine Source Type: research

Curcumin Alleviates Hyperandrogenism and Promotes Follicular Proliferation in Polycystic Ovary Syndrome Rats: Insights on IRS1/PI3K/GLUT4 and PTEN Modulations
ConclusionThe beneficial effects of curcumin on PCOS rats included the alteration of serum hormone levels and recovery of morphological ovarian lesions, in which, PTEN, a new target, may play a role in regulating the IRS1/PI3K/GLUT4 pathway. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 24, 2022 Category: Internal Medicine Source Type: research

Acupuncture Enhances Signals at Sensitized Acupoints to Elevate Pressure Pain Threshold in Knee Osteoarthritis Patients
ConclusionMA at sensitized acupoints could elevate PPT of KOA patients, which may be associated with the increment of SC and BP. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 24, 2022 Category: Internal Medicine Source Type: research

Efficacy and Mechanism of Buxue Yimu Pills on Gynecological Anemia: A Combination of Clinical and Network Pharmacology Study
ConclusionBYP contributes to the practical improvement on gynecological anemia potentially through multi-target mechanisms and optimized iron re-distribution. (Trial registration: No. NCT03232554) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 24, 2022 Category: Internal Medicine Source Type: research

Effect of Guizhi Fuling Capsule on Apoptosis of Myeloma Cells Through Mitochondrial Apoptosis Pathway
ConclusionGZFLC promoted apoptosis of myeloma cells through the mitochondrial apoptosis pathway and significantly reduced the tumor volumes in mice with myeloma, which prolonged the survival times of the mice. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 19, 2022 Category: Internal Medicine Source Type: research

3D Microfluidic System for Evaluating Inhibitory Effect of Chinese Herbal Medicine Oldenlandia diffusa on Human Malignant Glioma Invasion Combined with Network Pharmacology Analysis
Conclusions]EEOD could inhibit the invasion of human MG cells, and the anti-invasion mechanism of OD might be regulating MAPK and Wnt signaling pathways and microtubule cytoskeleton organization. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 19, 2022 Category: Internal Medicine Source Type: research

Nootkatone Improves Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors by Repressing NF- κB/NLRP3-Mediated Neuroinflammation
ConclusionNKT ameliorates the depressive-like symptoms, in part by repressing NF- κB/NLRP3-mediated neuroinflammation. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 19, 2022 Category: Internal Medicine Source Type: research

Active Ingredients of Reduning Injections Maintain High Potency against SARS-CoV-2 Variants
ConclusionsThe mechanisms were revealed of quercetin and luteolin inhibiting the infection of SARS-CoV-2 and its variants. Reduning Injection is a promising drug for COVID-19. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 14, 2022 Category: Internal Medicine Source Type: research

Transcutaneous Electrical Acupoint Stimulation Combined with Warm Acupuncture for Breast Cancer Related Upper Limb Lymphedema: A Retrospective Cohort Study
ConclusionsTEAS combined with warm acupuncture can effectively reduce AC and swelling feeling of the affected limb in patients with BCRL. The effect is better than that of CDT therapy alone. (Registration No. ChiCTR2200062075) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 14, 2022 Category: Internal Medicine Source Type: research

Classifying Chinese Medicine Constitution Using Multimodal Deep-Learning Model
ConclusionsMultimodal data fusion can supplement single model information and improve classification performance. Our research underscores the effectiveness of multimodal deep learning technology to identify body constitution for modernizing and improving the intelligent application of Chinese medicine. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 14, 2022 Category: Internal Medicine Source Type: research

Effects of Buyang Huanwu Decoction on Intestinal Barrier, Intestinal Flora, and Trimethylamine Oxide in Rats with Heart Failure
ConclusionBYHWD may delay progression of HF by enhancing the intestinal barrier structure, and regulating intestinal flora and TAMO. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - November 12, 2022 Category: Internal Medicine Source Type: research