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Emodin Ameliorates High Glucose-Induced Podocyte Apoptosis via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway
ConclusionEmodin ameliorated HG-induced apoptosis of MPC5 cellsin vitro that involved induction of autophagy through the AMPK/mTOR signaling pathway, which might provide a potential therapeutic option for diabetic nephropathy. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - October 11, 2022 Category: Internal Medicine Source Type: research

Current Status of Objectification of Four Diagnostic Methods on Constitution Recognition of Chinese Medicine
AbstractChinese medicine (CM) has thousands of years of experience in prevention of diseases. As for CM, people ’s constitution is closely related to their health status, thus recognition of CM constitution is the fundamental and core content of research on constitution types. With development of technologies such as sensors, artificial intelligence and big data, objectification of the four diagnostic metho ds of CM has gradually matured, bringing changes in the mindset and innovations in technical means for recognition of CM constitution. This paper presents a systematic review of the latest research trends in constitut...
Source: Chinese Journal of Integrative Medicine - September 28, 2022 Category: Internal Medicine Source Type: research

Effect of Berberine on Activation of TLR4-NF κB Signaling Pathway and NLRP3 Inflammasome in Patients with Goat
ConclusionsActivation of TLR4-NF κB signaling and NLRP3 inflammasome by MSU crystals drives the progression of gout inflammation. BBR ameliorates gouty inflammation, which is mechanistically associated with its regulation of TLR4-NF-κB signaling and NLRP3 inflammasome expression. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 20, 2022 Category: Internal Medicine Source Type: research

Ayurveda and in silico Approach: A Challenging Proficient Confluence for Better Development of Effective Traditional Medicine Spotlighting Network Pharmacology
This article discusses the convergence ofin silico work, especially in the least explored field of Ayurveda. The focused coalesce of these two domains could present a predictive combinatorial platform to enhance translational research magnitude. In nutshell, it could provide new insight into an Ayurvedic drug discovery involving anin silico approach that could not only alleviate the process of traditional medicine research but also enhance its effectiveness in addressing health care. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 12, 2022 Category: Internal Medicine Source Type: research

Network Pharmacology and in vitro Experimental Verification on Intervention of Quercetin, Present in Chinese Medicine Yishen Qutong Granules, on Esophageal Cancer
ConclusionYSQTG can be multi-component, multi-target, multi-channel treatment of esophageal cancer, it is a potential drug for the treatment of esophageal cancer. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 12, 2022 Category: Internal Medicine Source Type: research

Zhizhu Decoction Alleviates Intestinal Barrier Damage via Regulating SIRT1/FoxO1 Signaling Pathway in Slow Transit Constipation Model Mice
ConclusionZZD exhibited beneficial effects on the intestinal system of STC mice and alleviated intestinal inflammation and oxidative stress via activating SIRT1/FoxO1 antioxidant signaling pathway in the colon. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 31, 2022 Category: Internal Medicine Source Type: research

Flavonoid-Rich Extract of Oldenlandia diffusa (Willd.) Roxb. Inhibits Gastric Cancer by Activation of Caspase-Dependent Mitochondrial Apoptosis
ConclusionFlavonoids derived fromOldenlandia diffusa can inhibit proliferation and induce apoptosis of human gastric cancer cells by activating the mitochondrial controlled signal transduction pathway. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 31, 2022 Category: Internal Medicine Source Type: research

Mechanism Study on Chinese Medicine in Treatment of Nodular Goiter
AbstractNodular goiter has become increasingly prevalent in recent years. Clinically, there has been a burgeoning interest in nodular goiter due to the risk of progression to thyroid cancer. This review aims to provide a comprehensive summary of the mechanisms underlying the therapeutic effect of Chinese medicine (CM) in nodular goiter. Articles were systematically retrieved from databases, including PubMed, Web of Science and China National Knowledge Infrastructure. New evidence showed that CM exhibited multi-pathway and multi-target characteristics in the treatment of nodular goiter, involving hypothalamus-pituitary-thyr...
Source: Chinese Journal of Integrative Medicine - August 31, 2022 Category: Internal Medicine Source Type: research

Mechanism of Key Ingredient of Astragalus membranaceus on Lung Adenocarcinoma via PI3K/AKT Signaling Clarified by Utilizing Network Pharmacology Approach and Experimental Validation
ConclusionOur finding unraveled that an active ingredient ofA. membranaceus, quercetin, significantly inhibited the lung adenocarcinoma cells proliferation by repressing ERBB2 level and inactivating the PI3K/AKT signaling pathway. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 31, 2022 Category: Internal Medicine Source Type: research

Discussion on Collection of Clinical Questions in International Clinical Practice Guidelines of Acupuncture-Moxibustion
AbstractThe clinical questions of acupuncture-moxibustion (Acup-Mox) guidelines are complicated, including not only the curative effect of Acup-Mox intervention measures, but also the operational elements of Acup-Mox. This paper aimed to put forward the idea and process of collecting clinical questions in developing international acupuncture clinical practice guidelines. The experience was collected and the idea of collecting clinical questions of Acup-Mox was formed through expert consultation and discussion in combination with expert opinions. Based on the characteristics of Acup-Mox discipline. This paper put forward th...
Source: Chinese Journal of Integrative Medicine - August 31, 2022 Category: Internal Medicine Source Type: research

Protective Effect of Shenfu Injection on Vascular Endothelial Damage in a Porcine Model of Hemorrhagic Shock
ConclusionSFI attenuated endothelial injury in the porcine model of HS by inhibiting cell apoptosis, suppressing the formation of proinflammatory cytokines, and reducing endothelial activation. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 25, 2022 Category: Internal Medicine Source Type: research

Mechanism of Shengmai Injection on Anti-Sepsis and Protective Activities of Intestinal Mucosal Barrier in Mice
ConclusionSMI may exert its anti-sepsis activity mainly through NF- κB-pro-inflammatory factor-MLCK-TJ cascade. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 25, 2022 Category: Internal Medicine Source Type: research

Ethanol Extract of Glycyrrhiza uralensis Fisch: Antidiarrheal Activity in Mice and Contraction Effect in Isolated Rabbit Jejunum
ConclusionsGFR can effectively against diarrhea and inhibit intestinal contraction, and these antidiarrheal effects may be based on blocking L-type Ca2+ channels and muscarinic receptors. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 23, 2022 Category: Internal Medicine Source Type: research

Mechanisms of Chinese Medicine in Gastroesophageal Reflux Disease Treatment: Data Mining and Systematic Pharmacology Study
ConclusionEvodiae Fructus andCoptidis Rhizoma are the core drugs in the treatment of GERD and the potential mechanism of action of these medicines includes potential target and pathways. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 23, 2022 Category: Internal Medicine Source Type: research

Shenmai Injection Attenuates Myocardial Ischemia/Reperfusion Injury by Targeting Nrf2/GPX4 Signalling-Mediated Ferroptosis
ConclusionsFerroptosis is involved in myocardial I/R injury. Pretreatment with SMJ alleviated myocardial I/R injury by activating Nrf2/GPX4 signalling-mediated ferroptosis, thereby providing a strategy for the prevention and treatment of ischemic heart diseases. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 23, 2022 Category: Internal Medicine Source Type: research