Approach to Assess Adequacy of Acupuncture in Randomized Controlled Trials: A Systematic Review
ConclusionAssessment contents for adequacy or quality of acupuncture in RCTs hadn ’t still reached consensus and no widely used assessment tools appeared. The methodology of available assessment instruments/scales is far from formal and rigorous. A new instrument/tool assessing adequacy of acupuncture should be developed using a formal method. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - February 15, 2023 Category: Internal Medicine Source Type: research

Effect of Acupuncture on Endometrial Blood Flow in Women Undergoing in vitro Fertilization Embryo Transfer: A Single Blind, Randomized Controlled Trial
ConclusionsManual acupuncture performed after oocyte aspiration and before transplantation improved the endometrial blood flow parameters VI, RI and VFI in women who underwent IVF-ET, instead of sVI, sFI and sVFI. Therefore, acupuncture might be beneficial in women undergoing IVF-ET by increasing endometrial blood flow and endometrial receptivity. (Registration No. ChiCTR2100053354) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - February 15, 2023 Category: Internal Medicine Source Type: research

Medicinal Effects, Phytochemistry, Pharmacology of Euphorbia prostrata and Promising Molecular Mechanisms
AbstractEuphorbiaceae is a large family of dicotyledonous angiosperms with diverse genera includingEuphorbia prostrata (E. prostrata). Current research has provided scientific evidence for traditional uses ofE. prostrata against diverse pathological conditions such as anti-hemorrhoidal, anti-inflammatory, analgesic, wound healing, antioxidant, antibacterial, leishmanicidal, antitumor activity, and so on. The phytochemical screening has revealed the presence of glycosides, phytosterols, flavonoids, polyphenols, tannins, and anthraquinones with chemical structures elucidation of their respective compounds. The uniqueness of ...
Source: Chinese Journal of Integrative Medicine - January 18, 2023 Category: Internal Medicine Source Type: research

Electroacupuncture Improves Blood-Brain Barrier and Hippocampal Neuroinflammation in SAMP8 Mice by Inhibiting HMGB1/TLR4 and RAGE/NADPH Signaling Pathways
ConclusionEA may potentially improve cognitive impairment in AD via inhibition of fibrin/A β deposition and deactivation of the HMGB1/TLR4 and RAGE/NADPH signaling pathways. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 7, 2023 Category: Internal Medicine Source Type: research

Grape Seed Extract Attenuates Demyelination in Experimental Autoimmune Encephalomyelitis Mice by Inhibiting Inflammatory Response of Immune Cells
ConclusionGSE had a beneficial effect on the pathogenesis and progression of EAE by inhibiting inflammatory response as a potential drug and strategy for the treatment of MS. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 6, 2023 Category: Internal Medicine Source Type: research

Baicalin Ameliorates Corticosterone-Induced Depression by Promoting Neurodevelopment of Hippocampal via mTOR/GSK3 β Pathway
ConclusionBaicalin can promote the development of hippocampal neurons via mTOR/GSK3 β signaling pathway, thus protect mice against CORT-induced neurotoxicity and play an antidepressant role. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 6, 2023 Category: Internal Medicine Source Type: research

Total Saponin Fraction of Dioscorea Nipponica Makino Improves Gouty Arthritis Symptoms in Rats via M1/M2 Polarization of Monocytes and Macrophages Mediated by Arachidonic Acid Signaling
ConclusionThe anti-inflammatory effect of TSDN on rats with GA may be achieved by influencing M1/M2 polarization through AA signaling pathway. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 6, 2023 Category: Internal Medicine Source Type: research

Retrospective Clinical Study on Integrated Chinese and Western Medicine in Treatment of Limited-Stage Small Cell Lung Cancer
ConclusionThe combination treatment of CM and WM with continuing oral administration of CM treatment after the first-line chemoradiotherapy for LS-SCLC patients produced better prognosis, lower risks of progression, and longer survival than the WM treatment alone. (Registration No. ChiCTR2200056616) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - January 6, 2023 Category: Internal Medicine Source Type: research

Potential Medicinal Value of Rhein for Diabetic Kidney Disease
AbstractDiabetic kidney disease (DKD) is the primary cause of mortality among diabetic patients. With the increasing prevalence of diabetes, it has become a major concern around the world. The therapeutic effect of clinical use of drugs is far from expected, and therapy choices to slow the progression of DKD remain restricted. Therefore, research on new drugs and treatments for DKD has been a hot topic in the medical field. It has been found that rhein has the potential to target the pathogenesis of DKD and has a wide range of pharmacological effects on DKD, such as anti-nephritis, decreasing blood glucose, controlling blo...
Source: Chinese Journal of Integrative Medicine - January 6, 2023 Category: Internal Medicine Source Type: research

Leech-Centipede Granules Suppress EndMT to Improve Erectile Dysfunction in Rats with Diabetes Mellitus via TGF- β/Smad Pathway
ConclusionsLC Granules may improve the erectile function of DMED rats by suppressing TGF- β/Smad pathway to reverse EndMT. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 21, 2022 Category: Internal Medicine Source Type: research

Radix Panacis quinguefolii Root Extract Ameliorates Inflammatory Bowel Disease through Inhibiting Inflammation
ConclusionRPQE exhibited therapeutic effects on IBD by inhibiting inflammation. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 17, 2022 Category: Internal Medicine Source Type: research

Progress on Prevention and Treatment of Cerebral Small Vascular Disease Using Integrative Medicine
AbstractCerebral small vessel disease (CSVD) is a senile brain lesion caused by the abnormal structure and function of arterioles, venules and capillaries in the aging brain. The etiology of CSVD is complex, and disease is often asymptomatic in its early stages. However, as CSVD develops, brain disorders may occur, such as stroke, cognitive dysfunction, dyskinesia and mood disorders, and heart, kidney, eye and systemic disorders. As the population continues to age, the burden of CSVD is increasing. Moreover, there is an urgent need for better screening methods and diagnostic markers for CSVD, in addition to preventive and ...
Source: Chinese Journal of Integrative Medicine - December 17, 2022 Category: Internal Medicine Source Type: research

Kunxian Capsule Extract Inhibits Angiogenesis in Zebrafish Embryos via PI3K/AKT-MAPK-VEGF Pathway
ConclusionKX extract exhibited anti-angiogenic effects in zebrafish embryos by regulating PI3K/AKT-MAPK-VEGF pathway and showed promising potential for RA treatment. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 15, 2022 Category: Internal Medicine Source Type: research

Therapeutic Efficacy of Shexiang Baoxin Pill Combined with Exercise in Patients with Heart Failure with Preserved Ejection Fraction: A Single-Center, Double-Blind, Randomized Controlled Trial
ConclusionsExercise training improved exercise tolerance, sleep quality and quality of life (QoL) in patients with HFpEF. Notably, Shexiang Baoxin Pill played an active role in sleep quality and QoL of patients with HFpEF. (The trial was registered in the Chinese Clinical Trial Registry (No. ChiCTR2100054322)) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 9, 2022 Category: Internal Medicine Source Type: research

Bloodletting Acupuncture at Jing-Well Points Alleviates Myocardial Injury in Acute Altitude Hypoxic Rats by Activating HIF-1 α/BNIP3 Signaling-Mediated Mitochondrial Autophagy and Decreasing Oxidative Stress
ConclusionBAJP is an effective treatment for AHH-induced myocardial injury, and the mechanism might involve increasing HIF-1 α/BNIP3 signaling-mediated autophagy and decreasing oxidative stress. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 9, 2022 Category: Internal Medicine Source Type: research