Letter to the editors-in-chief reply to: Solinas et al. Venous and arterial thromboembolic events with immune check point inhibitors: A systematic review
We read with great interest the paper by Solinas et al. [1] published in a recent issue of Thrombosis Research. In their work, the authors reviewed and pooled data from 68 retrospective and prospective studies (n  = 20,273 patients) reporting the incidence rates of venous thromboembolism (VTE) and arterial thromboembolic events (ATE) in cancer patients treated with immune checkpoint inhibitors (ICI). They found pooled incidence rates of VTE and ATE of 2.7% (95%CI 1.8%–4%) and 1.1% (95%CI 0.5%–2.1%), respectively. (Source: Thrombosis Research)
Source: Thrombosis Research - March 3, 2021 Category: Hematology Authors: Corinne Frere, St éphane Ederhy, Joe-Elie Salem Tags: Letter to the Editors-in-Chief Source Type: research

Antithrombin deficiency: A pediatric disorder
Hereditary antithrombin (AT) deficiency is an autosomal dominant thrombophilic disorder. Guidelines do not support routine testing of children based on personal or familial thrombosis. (Source: Thrombosis Research)
Source: Thrombosis Research - March 3, 2021 Category: Hematology Authors: Natalie Smith, Beth Boulden Warren, Julie Smith, Linda Jacobson, Jennifer Armstrong, Jihye Kim, Jorge Di Paola, Marilyn Manco-Johnson Source Type: research

Invited commentary to: ADAMTS13 deficiency is associated with abnormal distribution of von Willebrand factor multimers in patients with COVID-19 by Tiffany Pascreau et al. Letter to the Editors-in-Chief, Thrombosis Research
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is the cause of a world-wide pandemic that has caused more than 2.5 million deaths worldwide as of mid February 2021 since its onset in December 2019. Severely affected patients suffer from pneumonia, necessitating invasive ventilation and several groups showed a high incidence and prevalence of venous and arterial thromboembolic events of large vessels and also microvascular thrombosis of the pulmonary circulation [1 –3]. Hemostatic laboratory parameters at admission of COVID-19 patients, especially strongly elevated D-dimer levels, were predicti...
Source: Thrombosis Research - March 3, 2021 Category: Hematology Authors: Bernhard L ämmle, Heidi Rossmann Tags: Letter to the Editors-in-Chief Source Type: research

The spectrum of FVIII gene variants detected by next generation sequencing in 236 Chinese non-inversion hemophilia a pedigrees
This study was performed to identify the causative variants in a large HA cohort from Chinese population. (Source: Thrombosis Research)
Source: Thrombosis Research - March 2, 2021 Category: Hematology Authors: Juanjuan Chen, Qiang Li, Sheng Lin, Fenxia Li, Limin Huang, Wangjie Jin, Xu Yang, Yihong Li, Kun Li, Yufeng Xiong, Dongmei Fan, Lei Zheng, Dixian Luo, Liyan Li, Xuexi Yang Source Type: research

Increased platelet glycoprotein IIb/IIIa activation precedes continuous-flow left ventricular assist device pump thrombosis events
Heart failure in the United States affects over 6.5 million people [1]. The continued rise of heart failure within the population and the limited supply of hearts for transplantation has led to an increase in mechanical cardiac support by continuous-flow left ventricular assist devices (CF-LVAD) [2]. The use of CF-LVAD in patients with end-stage heart failure improves quality of life and reduces short-term mortality in patients. Despite these benefits device related complications remain common especially within the first year. (Source: Thrombosis Research)
Source: Thrombosis Research - March 2, 2021 Category: Hematology Authors: Matthew Weiland, Jennifer Schuitema, Stefan Jovinge, Sangjin Lee Tags: Letter to the Editors-in-Chief Source Type: research

Inappropriate low dosing of direct oral anticoagulants in older patients with non-valvular atrial fibrillation: Impact on plasma drug levels
Direct oral anticoagulants (DOACs) are increasingly prescribed in older patients with non-valvular atrial fibrillation (NVAF). They provide higher convenience than vitamin K antagonists (VKA), with an improved efficacy and a reduced risk of intracranial bleeding [1]. Dose reduction criteria are clearly established for each DOAC, depending on renal function, weight, age or concomitant medications. However, many observational studies have reported that DOACs were frequently prescribed at an off-label dose, especially in older patients [2]. (Source: Thrombosis Research)
Source: Thrombosis Research - March 2, 2021 Category: Hematology Authors: Anne-Lore Comans, Anne-Laure Sennesael, Beno ît Bihin, Maxime Regnier, François Mullier, Marie de Saint-Hubert Tags: Letter to the Editor Source Type: research

A nomogram model to predict the venous thromboembolism risk after surgery in patients with gynecological tumors
Venous thromboembolism (VTE) is a common post-surgical complication of gynecological malignant tumors that has serious implications on the prognosis and quality-of-life of patients. However, there exists only a few recognized specific evaluation models for the occurrence of VTE after gynecological malignant tumor surgery. We aimed to establish a nomogram model that could predict the probability of post-surgical VTE in patients with gynecological malignancies. (Source: Thrombosis Research)
Source: Thrombosis Research - March 2, 2021 Category: Hematology Authors: Li Wang, Shanchen Wei, Bohui Zhou, Suhui Wu Source Type: research

Cancer risk after a venous thrombotic event - RIETE score
Unprovoked venous thromboembolism (VTE), may be the first sign of an occult cancer as 5 –10% of these patients will have a cancer diagnosis in the first year following a VTE [1,2]. Nevertheless the benefit and extension of cancer screening tests in this group of patients remains controversial [3]. The addition of computed tomography (CT) of abdomen/pelvis [4,5] or 18F-Fluorodesoxyglu cose Positron Emission Tomography/CT (FDG PET/CT) [6] did not yield more cancer diagnoses or a survival advantage, while unnecessarily increased costs and iatrogeny. (Source: Thrombosis Research)
Source: Thrombosis Research - March 2, 2021 Category: Hematology Authors: Joana Carvalho Mendon ça, João Martins, Carlos Fernandes, Carolina Carvalho, Camila Coutinho, Jorge Cotter Tags: Letter to the Editors-in-Chief Source Type: research

Editorial Board
(Source: Thrombosis Research)
Source: Thrombosis Research - March 1, 2021 Category: Hematology Source Type: research

Development and prospective validation of a novel risk score for predicting the risk of lower extremity deep vein thrombosis among multiple trauma patients
Trauma patients have an increased risk of deep vein thrombosis (DVT). Early identification of patients with a high risk of DVT after trauma is crucial for thromboembolism prophylaxis. We aimed to develop and prospectively validate a novel risk score based on a nomogram to predict lower extremity DVT among multiple trauma patients. (Source: Thrombosis Research)
Source: Thrombosis Research - February 26, 2021 Category: Hematology Authors: Guoxuan Peng, Qiang Wang, Hong Sun, Lebin Gan, Hongxiang Lu, Zhihong Deng, Jiali Sun, Jin Deng Tags: Full Length Article Source Type: research

Three-month follow-up of Pulmonary Embolism in patients with COVID-19
Coronavirus disease 2019 (COVID-19) infection has been notable for the occurrence of pulmonary venous thrombosis, also known as immunothrombosis, in addition to classical pulmonary embolism [1]. The pathophysiology underpinning this appears more platelet-dependent and related to viral-mediated endothelial inflammation, in addition to hypercoagulability [2]. To date, treatment of confirmed pulmonary embolism (PE) has followed established (pre-COVID) venous thromboembolism (VTE) guidelines [3] but it is not known whether the subsequent clinical behaviour of COVID-associated VTE differs from outcomes reported prior to the COV...
Source: Thrombosis Research - February 26, 2021 Category: Hematology Authors: Martin B. Whyte, Rosemary Barker, Philip A. Kelly, Elisa Gonzalez, Julia Czuprynska, Raj K. Patel, Catherine Rea, Felicity Perrin, Michael Waller, Caroline Jolley, Roopen Arya, Lara N. Roberts Tags: Letter to the Editors-in-Chief Source Type: research

Influence of PAR-1 in patients with non-valvular atrial fibrillation: The antiplatelet effect of dabigatran
Dabigatran, a direct thrombin inhibitor, has been widely used in patients with non-valvular atrial fibrillation (NVAF) and is considered to have an antiplatelet effect. However, the mechanisms remain unclear. We evaluated protease-activated receptor-1 (PAR-1) expression and activation by thrombin on platelets from NVAF patients, before and after dabigatran treatment, in addition to the expression of platelet activation marker CD62P. (Source: Thrombosis Research)
Source: Thrombosis Research - February 25, 2021 Category: Hematology Authors: Kiyotaka Oi, Mie Shimizu, Tatsunori Natori, Keisuke Tsuda, Makiko Yoshida, Asami Kamada, Yoko Ishigaku, Shinsuke Narumi, Kazumasa Oura, Tetsuya Maeda, Yasuo Terayama Source Type: research

Bias and uncertainty of the International Normalized Ratio determined with a whole blood point-of-care prothrombin time test device by comparison to a new International Standard for thromboplastin
Whole blood point-of-care PT/INR test devices, e.g. CoaguChek XS, are calibrated by their manufacturers. In the Netherlands, each new lot of test strips for CoaguChek XS is validated by a group of anticoagulant clinics collaborating with a Coagulation Reference Laboratory. In 2017, a new International Standard for recombinant human thromboplastin (coded rTF/16) has been established by the World Health Organization. (Source: Thrombosis Research)
Source: Thrombosis Research - February 24, 2021 Category: Hematology Authors: Antonius M.H.P. van den Besselaar, Claudia J.J. van Rijn, Charmane F. Abdoel, Christa M. Cobbaert Tags: Full Length Article Source Type: research

Venous thromboembolism in solid-organ transplant recipients: Findings from the RIETE registry
Venous thromboembolism (VTE) represents a relevant cause of morbidity in patients with solid-organ transplant (SOT), but there are scarce data on the management and outcomes in these patients. (Source: Thrombosis Research)
Source: Thrombosis Research - February 24, 2021 Category: Hematology Authors: AlbertoGarc ía Ortega, Raquel López-Reyes, Gabriel Anguera, Grace Oscullo, Agustina Rivas, Luciano López-Jiménez, Alicia Lorenzo, Isabelle Mahé, Maurizio Ciammaichella, Manuel Monreal, M.D. Adarraga, M. Agud, J. Aibar, M.A. Aibar, C. Amado, J.I. Arce Source Type: research

Massive intrasplenic arterial thrombosis in a patient with chronic ITP during the development of an Evans syndrome
We report an interesting case of splenic rupture due to massive intrasplenic arterial thrombosis in the course of ES in a patient with chronic ITP treated with eltrombopag. (Source: Thrombosis Research)
Source: Thrombosis Research - February 24, 2021 Category: Hematology Authors: R. Diez-Feij óo, J.J. Rodríguez-Sevilla, L. Colomo, N. Papaleo, J.M. Maiques, E. Gimeno, M. Andrade, E. Abella, B.M. Merchan, X. Calvo, C. Jimenez, O.D. Román, A. Salar, B. Sanchez-Gonzalez Source Type: research

Venous thromboembolism in Asia and worldwide: Emerging insights from GARFIELD-VTE
Although epidemiological studies report a lower risk of venous thromboembolism (VTE) than in the Western world, VTE rates in Asia may be underestimated. Furthermore, it is uncertain whether VTE outcomes differ in Asia and the rest of the world (ROW). (Source: Thrombosis Research)
Source: Thrombosis Research - February 24, 2021 Category: Hematology Authors: Pantep Angchaisuksiri, Shinya Goto, Alfredo E. Farjat, Henrik Fryk, Soo-Mee Bang, Chern-En Chiang, Zhi-Cheng Jing, Katsuhiro Kondo, Jameela Sathar, Eric Tse, Sithakom Phusanti, Gloria Kayani, Jeffrey I. Weitz, Walter Ageno, Samuel Z. Goldhaber, Ajay K. Ka Source Type: research

Suggestions for global coagulation assays for the assessment of COVID-19 associated hypercoagulability
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection is associated with a clear prothrombotic phenotype. Although the exact pathophysiological mechanisms are not yet fully understood, thrombosis is clearly a highly important in the prognosis and outcome of COVID-19. As such, there is a need for diagnostic analysis and quantification of the coagulation potential in these patients, both at diagnosis and follow-up. Global coagulation assays like thrombin generation (TG) and rotational thromboelastometry (ROTEM) might be suitable in estimating COVID-19 associated coagulopathy and thrombosis risk. (Source: Thrombosis Research)
Source: Thrombosis Research - February 24, 2021 Category: Hematology Authors: T.W. van de Berg, A.M. Hulshof, Magdolna Nagy, Rene van Oerle, Jan-Willem Sels, Bas van Bussel, Hugo ten Cate, Yvonne Henskens, Henri M.H. Spronk, Dutch Covid-19 and Thrombosis Coalition (DCTC) Tags: Full Length Article Source Type: research

Efficacy of a nitroglycerin-citrate-ethanol lock solution in maintaining central venous catheter patency and preventing thrombotic occlusions in cancer patients
Indwelling central venous catheters (CVCs) provide life-sustaining vascular access in severely ill patients, such as those with cancer. Nonetheless, they are susceptible to microbial colonization and loss of patency due to luminal occlusion. The most commonly reported causes of CVC malfunction are patency failure (PF) and CVC-associated infections [1]. The loss of catheter patency, which can lead to the inability to use one or more of the lumina for treatment, can develop via three different mechanisms: thrombosis, mechanical obstruction, and chemical buildup of precipitates on the catheter walls. (Source: Thrombosis Research)
Source: Thrombosis Research - February 19, 2021 Category: Hematology Authors: Khalil Melissa, Chaftari Anne Marie, Dagher Hiba, Rosenblatt Joel, Jiang Ying, A. Reitzel Ruth, Hachem Ray, Hirsh-Ginsberg Cheryl, Raad I. Issam Tags: Letter to the Editors-in-Chief Source Type: research

Pulmonary and cardiac variables associated with persistent dyspnea after pulmonary embolism
Persistent dyspnea is common in follow-up after pulmonary embolism (PE), but the underlying mechanisms are poorly understood. (Source: Thrombosis Research)
Source: Thrombosis Research - February 18, 2021 Category: Hematology Authors: Øyvind Jervan, Jostein Gleditsch, Mazdak Tavoly, Frederikus A. Klok, Diyar Rashid, René Holst, Kjetil Steine, Knut Stavem, Waleed Ghanima Source Type: research

Special series on challenging anticoagulation cases: Experience counts when guidelines fall short
Healthcare providers turn with increasing frequency to clinical guidelines for advice on how to best manage their patients. These guidelines improve quality of care by minimizing the gap between scientific evidence and clinical practice, while helping to enhance the consistency and efficiency of patient care [1]. However, what is recommended by guideline bodies for a subset of patients may not be right for the individual patient, particularly those who by virtue of their clinical characteristics have not been included in rigorous clinical trials. (Source: Thrombosis Research)
Source: Thrombosis Research - February 17, 2021 Category: Hematology Authors: Shannon M. Bates, Frederikus A. Klok Tags: Editorial Source Type: research

Special Series on Challenging Anticoagulation Cases: Experience Counts when Guidelines Fall Short.
Healthcare providers turn with increasing frequency to clinical guidelines for advice on how to best manage their patients. These guidelines improve quality of care by minimizing the gap between scientific evidence and clinical practice, while helping to enhance the consistency and efficiency of patient care [1]. However, what is recommended by guideline bodies for a subset of patients may not be right for the individual patient, particularly those who by virtue of their clinical characteristics have not been included in rigorous clinical trials. (Source: Thrombosis Research)
Source: Thrombosis Research - February 17, 2021 Category: Hematology Authors: Shannon M. Bates, Frederikus A. Klok Source Type: research

Recombinant ADAMTS13 reduces abnormally up-regulated von Willebrand factor in plasma from patients with severe COVID-19
Thrombosis affecting the pulmonary and systemic vasculature is common during severe COVID-19 and causes adverse outcomes. Although thrombosis likely results from inflammatory activation of vascular cells, the mediators of thrombosis remain unconfirmed. In a cross-sectional cohort of 36 severe COVID-19 patients, we show that markedly increased plasma von Willebrand factor (VWF) levels were accompanied by a partial reduction in the VWF regulatory protease ADAMTS13. In all patients we find this VWF/ADAMTS13 imbalance to be associated with persistence of ultra-high-molecular-weight (UHMW) VWF multimers that are highly thrombog...
Source: Thrombosis Research - February 17, 2021 Category: Hematology Authors: Peter L. Turecek, Rachel C. Peck, Savita Rangarajan, Christopher Reilly-Stitt, Michael A. Laffan, Rashid Kazmi, Izabela James, Ahilanandan Dushianthan, Gerald Schrenk, Herbert Gritsch, Bruce M. Ewenstein, Bjorn Mellgard, Wolfhard Erdlenbruch, Nisha Jain, Source Type: research

Peak plasma rivaroxaban levels in patients weighing 120  kg or greater
Direct oral anticoagulants (DOACs) have become the drug of choice, increasingly replacing traditional vitamin K antagonists (VKA) for stroke prevention in atrial fibrillation (AF) and in the treatment of venous thromboembolism (VTE) due to their advantages of fixed dosing and no requirement for drug monitoring. Furthermore, their use is expanding into the ischemic heart disease population [1]. However, there is ongoing concern regarding their use in those weighing ≥120 kg or who have a body mass index (BMI) ≥ 40 due to limited representation of this patient group in the phase 3 DOAC trials [2,3]. (Source: Thrombosis Research)
Source: Thrombosis Research - February 17, 2021 Category: Hematology Authors: Jameel Abdulrehman, Rita Selby, Raed A. Joundi, Erik Yeo Tags: Letter to the Editors-in-Chief Source Type: research

Are the correct outcomes being measured in studies of Oral anticoagulants? A systematic survey
This study aimed to describe and classify the outcomes used in recent prospective clinical studies involving OACs. (Source: Thrombosis Research)
Source: Thrombosis Research - February 17, 2021 Category: Hematology Authors: Mei Wang, Zhiyuan Chen, Michael Wong, Lehana Thabane, Lawrence Mbuagbaw, Deborah Siegal, Gregoire Le Gal, Anne Holbrook Source Type: research

A population-based analysis on the use of therapeutic plasma exchange and intravenous immunoglobulin in heparin-induced thrombocytopenia
In heparin-induced thrombocytopenia (HIT), selected patients are treated with therapies directed at the immune response, intravenous immunoglobulin (IVIG) and therapeutic plasma exchange (TPE). To determine IVIG and TPE characteristics and outcomes in HIT, we analyzed the National Inpatient Sample (NIS) database. (Source: Thrombosis Research)
Source: Thrombosis Research - February 17, 2021 Category: Hematology Authors: Alexandre Soares Ferreira J únior, Stephen H. Boyle, Maragatha Kuchibhatla, Oluwatoyosi A. Onwuemene Source Type: research

Venous thromboembolism and risk of Cancer in users of statins: A Danish population-based cohort study
Venous thromboembolism (VTE) may be the first symptom of cancer. Statins are suggested to prevent VTE, but the risk of cancer in VTE patients using statins remains poorly understood. (Source: Thrombosis Research)
Source: Thrombosis Research - February 17, 2021 Category: Hematology Authors: Nils Skajaa, David Nagy, Frederikke Sch ønfeldt Troelsen, Dóra Körmendiné Farkas, Henrik Toft Sørensen Source Type: research

DIC in COVID-19
Coronavirus disease 2019 (COVID-19) is a novel infectious disease, with significant morbidity and mortality. This meta-analysis is to evaluate the prevalence of disseminated intravascular coagulation (DIC) in COVID-19 patients and to determine the association of DIC with the severity and prognosis of COVID-19. (Source: Thrombosis Research)
Source: Thrombosis Research - February 16, 2021 Category: Hematology Authors: Xianghui Zhou, Zhipeng Cheng, Lili Luo, Ying Zhu, Wenyi Lin, Zhangyin Ming, Wei Chen, Yu Hu Source Type: research

Familial Hypercholesterolemia: is there a role for PCSK9 and thrombin generation?
This study aimed to evaluate the proprotein convertase subtilisin/kexin 9 (PCSK9) levels, lipid profile and thrombin generation in FH patients undergoing treatment or not. (Source: Thrombosis Research)
Source: Thrombosis Research - February 15, 2021 Category: Hematology Authors: J.P.P. Silvino, M.G. Carvalho, E.A. Reis, A.P.L. Mota, K.B. Gomes, R.C.F. Duarte, M.C.J. Guimar ães, M.C.R. Sousa, P.S. Azevedo, I.F.O. Silva Source Type: research

Therapeutic Anticoagulation in COVID-19 Patients
(Source: Thrombosis Research)
Source: Thrombosis Research - February 15, 2021 Category: Hematology Authors: O. Belfaqeeh, J. Patel, Janapala, A. Pourmand Tags: Letter to the Editors-in-Chief Source Type: research

Nephrotic Syndrome Disease Activity is Proportional to its Associated Hypercoagulopathy
The objective of this study was thus to establish the relationship between disease severity and hypercoagulopathy in human NS. (Source: Thrombosis Research)
Source: Thrombosis Research - February 15, 2021 Category: Hematology Authors: Amanda P. Waller, Jonathan P. Troost, Samir V. Parikh, Katelyn J. Wolfgang, Brad H. Rovin, Marvin T. Nieman, William E. Smoyer, Matthias Kretzler, Bryce A. Kerlin, for The NEPTUNE Investigators Source Type: research

Fondaparinux and bleeding risk in COVID-19: unsolved question
(Source: Thrombosis Research)
Source: Thrombosis Research - February 8, 2021 Category: Hematology Authors: Vincenzo Russo, Riccardo Proietti, Corrado Lodigiani, Pierpaolo Di Micco Tags: Letter to the Editors-in-Chief Source Type: research

Effects of antithrombotic drugs on the prothrombotic state in patients with atrial fibrillation: The West Birmingham atrial fibrillation project
Direct oral anticoagulants (DOACs) are known to prevent thrombosis but there is limited information about their activity on the clot formation and lysis cascade. (Source: Thrombosis Research)
Source: Thrombosis Research - February 8, 2021 Category: Hematology Authors: Christos Voukalis, Gregory Y.H. Lip, Eduard Shantsila Source Type: research

ADAMTS 13 deficiency is associated with abnormal distribution of von Willebrand factor multimers in patients with COVID-19
(Source: Thrombosis Research)
Source: Thrombosis Research - February 8, 2021 Category: Hematology Authors: Tiffany Pascreau, Sara Zia-Chahabi, Benjamin Zuber, Colas Tcherakian, Eric Farfour, Marc Vasse Tags: Letter to the Editors-in-Chief Source Type: research

Selatogrel, a Reversible P2Y12 Receptor Antagonist, Has Reduced Off-target Interference with Haemostatic Factors in a Mouse Thrombosis Model
Selatogrel is a reversible antagonist of the P2Y12 receptor. In rat thrombosis/haemostasis models, selatogrel was associated with lower blood loss than clopidogrel or ticagrelor at equivalent anti-thrombotic effect. (Source: Thrombosis Research)
Source: Thrombosis Research - February 6, 2021 Category: Hematology Authors: Markus A. Riederer, Lydie Crescence, Roxane Darbousset, Eva Caroff, Francis Hubler, Laurence Panicot-Dubois, Christophe Dubois Source Type: research

Diagnostic accuracy of four different D-dimer assays: a post-hoc analysis of the YEARS study
For exclusion of pulmonary embolism (PE) clinical decision rules in combination with a D-dimer assay are applied. Currently available D-dimer assays are not standardized and it is unknown whether these differences have an impact on diagnostic management of suspected PE. Therefore, the aim is to explore differences between D-dimer assays and their impact on diagnostic outcome. (Source: Thrombosis Research)
Source: Thrombosis Research - February 6, 2021 Category: Hematology Authors: Henrike M. Hamer, An K. Stroobants, Roisin Bavalia, Gabrielle A.E. Ponjee, Federicus A. Klok, Tom van der Hulle, Menno V. Huisman, Henri ët A. Hendriks, Saskia Middeldorp Source Type: research

Hemodialysis-Related Low Thrombogenicity Measured by Total Thrombus-formation Analysis System in Patients Undergoing Percutaneous Coronary Intervention
Established antithrombotic therapies can increase bleeding risk, especially in hemodialysis (HD) patients. The Total Thrombus-formation Analysis System (T-TAS) is useful for evaluating thrombogenicity. The aim of this study was to examine the relationship between HD and thrombogenicity, or bleeding events in patients undergoing percutaneous coronary intervention (PCI). (Source: Thrombosis Research)
Source: Thrombosis Research - February 6, 2021 Category: Hematology Authors: Nobuhiro Nakanishi, Koichi Kaikita, Masanobu Ishii, Naoto Kuyama, Noriaki Tabata, Miwa Ito, Kenshi Yamanaga, Koichiro Fujisue, Tadashi Hoshiyama, Hisanori Kanazawa, Shinsuke Hanatani, Daisuke Sueta, Seiji Takashio, Yuichiro Arima, Satoshi Araki, Hiroki Us Tags: Original Investigation Source Type: research

Racial Differences in Platelet Serotonin Polymorphisms in Acute Coronary Syndrome
Genetic differences between races have been hypothesized to contribute to differences in outcome from acute coronary syndromes (ACS). Our objective was to assess racial differences in genetic variations in the platelet serotonin transporter (5HTT) and receptor in patients with ACS. (Source: Thrombosis Research)
Source: Thrombosis Research - February 6, 2021 Category: Hematology Authors: Marlene S. Williams, Lisa Yanek, Roy C. Ziegelstein, Una McCann, Nauder Faraday Source Type: research

Early effects of unfractionated heparin on clinical and radiological signs and D-dimer levels in patients with COVID-19 associated pulmonary embolism: An observational cohort study
(Source: Thrombosis Research)
Source: Thrombosis Research - February 2, 2021 Category: Hematology Authors: L.I. van der Wal, L.J.M. Kroft, L.F. van Dam, C.M. Cobbaert, J. Eikenboom, M.V. Huisman, H.J.F. Helmerhorst, F.A. Klok, E. de Jonge, for the Dutch COVID & Thrombosis Coalition (DCTC) Tags: Letter to the Editors-in-Chief Source Type: research

Editorial Board
(Source: Thrombosis Research)
Source: Thrombosis Research - February 1, 2021 Category: Hematology Source Type: research

Direct oral anticoagulant plasma level measurement in clinical practice: a French single-institution retrospective study
To describe patient characteristics and clinical situations where DOAC assays were ordered and determine whether the assays indications and subsequent patient management were consistent with current guidelines. (Source: Thrombosis Research)
Source: Thrombosis Research - February 1, 2021 Category: Hematology Authors: Weniko Car é, Vincent Foissaud, Leslie Lefeuvre, Jean-Louis Daban, Dominique Vodovar, Marc Aletti, Caroline Doutrelon Tags: Letter to the Editors-in-Chief Source Type: research

Impact of double heterozygosity for Factor V Leiden and Prothrombin G20210A on the thrombotic phenotype
Because of the rarity of double heterozygosity for Factor V Leiden (FVL) and Prothrombin (FII) G20210A, little is known about the thrombotic phenotype in double heterozygotes. (Source: Thrombosis Research)
Source: Thrombosis Research - February 1, 2021 Category: Hematology Authors: Beate Luxembourg, Franziska Henke, Anette Kirsch-Altena, Ulrich Sachs, Bettina Kemkes-Matthes Source Type: research

An international survey of low molecular weight heparin prescribing in the context of antenatal venous thromboembolism
(Source: Thrombosis Research)
Source: Thrombosis Research - February 1, 2021 Category: Hematology Authors: Sophia Quirke McFarlane, Jignesh P. Patel, Vivian Auyeung, Roopen Arya Tags: Letter to the Editors-in-Chief Source Type: research

Temporal and Anatomic Relationship between Superficial and Deep Vein Thromboses in Hospitalized Children
Recent publications have increasingly demonstrated a link between superficial-vein thrombosis (SVT) and deep-vein thrombosis (DVT) in the adult population and have led to changes in SVT treatment considerations. A similar relationship between SVT and DVT in pediatric populations, however, is not currently well established. (Source: Thrombosis Research)
Source: Thrombosis Research - January 25, 2021 Category: Hematology Authors: Peter Doan, Allaura Cox, Emily Rao, Brian Branchford Source Type: research

Impact of the use of rivaroxaban in the length of stay of patients treated for acute venous thromboembolism in a developing country
(Source: Thrombosis Research)
Source: Thrombosis Research - January 25, 2021 Category: Hematology Authors: B. Boietti, S. Fili, V. Peuchot, A. Tabares, F. V ázquez, E. Gándara Tags: Letter to the Editors-in-Chief Source Type: research

Procoagulant activity in high grade serous ovarian cancer patients following neoadjuvant chemotherapy-the role of the activated protein c pathway
Ovarian cancer patients are at high risk of thrombosis particularly during chemotherapy treatment however the mechanism is not understood. The aim of this study is to investigate the role of the activated protein C (APC) pathway in the procoagulant activity observed in ovarian cancer patients undergoing neoadjuvant chemotherapy. (Source: Thrombosis Research)
Source: Thrombosis Research - January 25, 2021 Category: Hematology Authors: Mark P. Ward, Feras Abu Saadeh, Sharon A. O ’Toole, John J. O’Leary, Noreen Gleeson, Lucy A. Norris Source Type: research

Coronavirus disease 2019 is associated with catheter-related thrombosis in critically ill patients: a multicenter case-control study
(Source: Thrombosis Research)
Source: Thrombosis Research - January 25, 2021 Category: Hematology Authors: Jasper M. Smit, Jorge E. Lopez Matta, Roel Vink, Marcella C.A. M üller, Kee F. Choi, Frank E.H.P. van Baarle, Alexander P.J. Vlaar, Frederikus A. Klok, Menno V. Huisman, Carlos V. Elzo Kraemer, Armand R.J. Girbes, David J. Van Westerloo, Pieter R. Tuinma Tags: Letter to the Editors-in-Chief Source Type: research

Incidence and risk factors of venous thrombotic events in pediatric patients with cns tumors compared with non-cns cancer: a population-based cohort study
Venous thromboembolism (VTE) is a well-recognized complication in pediatric cancer patients. It has been demonstrated that the incidence of VTE in pediatric patients with central nervous system (CNS) tumors is lower than that of patients with other cancers. Risk factors for developing cancer-related thrombosis are numerous and can include patient, disease, or treatment-related influences. The present study was designed to assess the VTE incidence in a pediatric oncology population, and to investigate whether intensity of treatment has similar associated with risk of VTE development in patients with and without CNS tumors. ...
Source: Thrombosis Research - January 25, 2021 Category: Hematology Authors: Chelsea Howie, Craig Erker, Bruce Crooks, Paul Moorehead, Ketan Kulkarni Source Type: research

Sulfated Non-anticoagulant Low Molecular Weight Heparin in the Prevention of Cancer and Non-cancer Associated Thrombosis Without Compromising Hemostasis
Cancer-associated thrombosis (CAT) accounts for about 20% of all cases of Venous Thromboembolism (VTE). Tissue factor (TF) is documented to be highly expressed on cancer cells and pathological angiogenic endothelial cells. Here, we used a novel oxidized sulfated ultra-LMWH, S-NACH, which is devoid of anti-factor Xa and IIa activities with limited to no systemic anticoagulant effects. This sulfated form has enhanced binding to vascular endothelial cells (EC), and releases and potentiates the action of tissue factor pathway inhibitor (TFPI). (Source: Thrombosis Research)
Source: Thrombosis Research - January 25, 2021 Category: Hematology Authors: Noureldien H.E. Darwish, Kavitha Godugu, Shaker A. Mousa Source Type: research

Challenging anticoagulation cases: a case of pulmonary embolism shortly after spontaneous brain bleeding
Venous thromboembolism (VTE) is a common complication after intracranial hemorrhage (ICH); the incidence has been reported to vary between 18% to 50% for deep vein thrombosis and between 0.5% to 5% for pulmonary embolism (PE). According to current clinical practice guidelines, patients with acute VTE should receive anticoagulant treatment for at least 3 months in the absence of contraindications. Anticoagulant treatment reduces mortality, prevents early recurrences and improves long-term outcome in patients with acute VTE. (Source: Thrombosis Research)
Source: Thrombosis Research - January 25, 2021 Category: Hematology Authors: Cecilia Becattini, Ludovica Anna Cimini, Marc Carrier Source Type: research

Use of Anti-Factor Xa Levels in Cancer Patients Taking Direct Oral Anticoagulants
(Source: Thrombosis Research)
Source: Thrombosis Research - January 25, 2021 Category: Hematology Authors: Zara Sayar, Anna Weatherill, Carolyn Gates, Mari Thomas Tags: Letter to the Editors-in-Chief Source Type: research