Emodin inhibits tonic tension through suppressing PKCδ‐mediated inhibition of myosin phosphatase in isolated rat thoracic aorta
Conclusion and implicationsTaken together, we demonstrated that emodin attenuates tonic tension through the blockade of PKCδ and CPI‐17 mediated MLC‐phosphatase inhibition. This new mode of action for the suppression of tonic tension and a structural insight for PKCδ inhibition given by emodin may provide a new insight for the development of modulators of tonic tension and hypertensive diseases.
Source: British Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Kyung‐Min Lim, Jae‐Hyuk Kwon, Keunyoung Kim, Ji‐Yoon Noh, Seojin Kang, Jung‐Min Park, Moo‐Yeol Lee, Ok‐Nam Bae, Jin‐Ho Chung Tags: Research Paper Source Type: research
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