To Do or Not to Do: Whether to Hold or Continue Antithrombotics before Endoscopy.
Authors: Kim JS, Kim BW PMID: 32400143 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - May 15, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Strategies to Increase the Participation Rate of Colorectal Cancer Screening.
Authors: Jung YS PMID: 32400144 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - May 15, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

A New Era of Endoscopic Ultrasound-Guided Tissue Acquisition for Next-Generation Sequencing for Pancreatic Cancer.
Authors: Song TJ PMID: 32400145 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - May 15, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Astragalin Inhibits Nuclear Factor- κB Signaling in Human Colonic Epithelial Cells and Attenuates Experimental Colitis in Mice.
Conclusions: Astragalin exerted an anti-inflammatory effect through NF-κB pathway inhibition and attenuated murine colitis. Astragalin is thus a potential therapeutic agent for IBD. PMID: 32390406 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - May 13, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Characteristics of the Gut Microbiome of Healthy Young Male Soldiers in South Korea: The Effects of Smoking.
Conclusions: A high abundance of Actinobacteria and low abundance of Bacteroidetes were the main features distinguishing the gut microbiomes of HYMS, and current smokers could be differentiated from noncurrent smokers by their lower abundance of Bifidobacterium and higher abundance of Negativicutes. PMID: 32390407 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - May 13, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

A Comparative Study on Aqueous Chitosan Solution and Various Submucosal Injection Fluids Using a Three-Dimensional Sensor.
Authors: Jeon HJ, Jeong S, Choi HS, Jang SH, Kim SH, Kim SH, Lee JM, Kim ES, Keum B, Jeen YT, Lee HS, Chun HJ, Chung JH, Kim SN Abstract Background/Aims: Chitosan, a natural polymer widely used in the biomaterials field, has been proposed as a potential submucosal injection solution. The purpose of this study was to compare the performance and efficacy of aqueous chitosan solution and commercialized submucosal injection fluids using a three-dimensional sensor and to evaluate the efficacy of the measured parameters. Methods: Normal saline (0.9% NaCl), as a control, Eleview® (Poloxamer 188), Blue EyeTM (0.4% ...
Source: Gut and Liver - May 13, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

CD31 and D2-40 Contribute to Peritoneal Metastasis of Colorectal Cancer by Promoting Epithelial-Mesenchymal Transition.
Conclusions: CD31 and D2-40 contribute to CRPM by promoting EMT and may serve as prognostic markers and therapeutic targets for CRC, particularly in patients with peritoneal metastasis. PMID: 32390409 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - May 13, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Incidence and Significance of Biliary Stricture in Chronic Pancreatitis Patients Undergoing Extracorporeal Shock Wave Lithotripsy for Obstructing Pancreatic Duct Stones.
Conclusions: Although periductal fibrosis is the main mechanism underlying biliary stricture development in chronic pancreatitis, inflammation induced by obstructing pancreatic calculi, including pseudocysts, is an important contributing factor to SBS formation during the acute phase. PMID: 32393009 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - May 13, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Molecular Features of the Serrated Pathway to Colorectal Cancer: Current Knowledge and Future Directions.
Authors: Satorres C, García-Campos M, Bustamante-Balén M Abstract Serrated lesions are the precursor lesions of a new model of colorectal carcinogenesis. From a molecular standpoint, the serrated pathway is thought to be responsible for up to 30% of all colorectal cancer cases. The three major processes of this molecular mechanism are alterations in the mitogen-activated protein kinase pathway, production of the CpG island methylation phenotype, and generation of microsatellite instability. Other contributing processes are activation of WNT, alterations in the regulation of tumor suppressor genes, and...
Source: Gut and Liver - April 30, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

A Prospective Multicenter Study of Partially Covered Metal Stents in Patients Receiving Neoadjuvant Chemotherapy for Resectable and Borderline Resectable Pancreatic Cancer: BTS-NAC Study.
Conclusions: Biliary drainage by PCSEMS was safe and feasible in patients undergoing NAC for resectable and borderline resectable PC. PMID: 32340436 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 30, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Proton Pump Inhibitor-Related Gastric Mucosal Changes.
Authors: Kim GH Abstract Proton pump inhibitors (PPIs) are used worldwide to treat of acid-related disorders such as peptic ulcer and gastroesophageal reflux disease and to prevent gastroduodenal injuries due to nonsteroidal anti-inflammatory drugs. PPIs are the most potent inhibitors of gastric acid secretion currently available, and they are one of the most commonly prescribed classes of drugs because of their high efficacy and low toxicity. However, long-term PPI use causes histopathological changes such as parietal cell protrusion into the gland lumen, cystic dilation of gastric fundic glands, and foveolar epit...
Source: Gut and Liver - April 26, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Characteristics and Early Diagnosis of Gastric Cancer Discovered after Helicobacter pylori Eradication.
Authors: Ito M, Tanaka S, Chayama K Abstract The prevalence of gastric cancer after eradication (GCAE) is increasing dramatically in Japan. GCAE has characteristic features, and we must understand these features in endoscopic examinations. Differentiated cancer types were frequently found after eradication and included characteristic endoscopic features such as reddish depression (RD). However, benign RD can be difficult to distinguish from gastric cancer because of histological alterations in the surface structures (nonneoplastic epithelium or epithelium with low-grade atypia [ELA]) as well as multiple appearances...
Source: Gut and Liver - April 25, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Comparison of Sorafenib versus Hepatic Arterial Infusion Chemotherapy-Based Treatment for Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis.
This study aimed to compare the efficacy of sorafenib-based therapy with that of HAIC-based therapy for advanced HCC with main PVTT. Methods: Advanced HCC patients with main PVTT treated with sorafenib or HAIC between 2008 and 2016 at Korea University Medical Center were included. We evaluated overall survival (OS), time-to-progression (TTP), and the disease control rate (DCR). Results: Seventy-three patients were treated with sorafenib (n=35) or HAIC (n=38). Baseline characteristics were not significantly different between groups, except the presence of solid organ metastasis (46% vs 5.3%, p
Source: Gut and Liver - April 22, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Current Status of Mucosal Imaging with Narrow-Band Imaging in the Esophagus.
Authors: Chiam KH, Shin SH, Choi KC, Leiria F, Militz M, Singh R Abstract Recent advances in endoscopic imaging of the esophagus have revolutionized the diagnostic capability for detecting premalignant changes and early esophageal malignancy. In this article, we review the practical application of narrow-band imaging focusing on diseases of the esophagus, including Barrett's esophagus, adenocarcinoma, and squamous cell carcinoma. PMID: 32307976 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 22, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Autoimmune Hepatitis: 2019 Update.
Authors: Tanaka A Abstract Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease, characterized by the elevation of aminotransferases, presence of anti-nuclear antibody or anti-smooth muscle antibody, elevated immunoglobulin G (IgG), and interface hepatitis/plasma-lymphocytic inflammation based on histology. Recent epidemiological studies have indicated an increasing trend in the prevalence of AIH worldwide, especially in male patients; this trend may suggest the alteration of environmental triggers of disease onset over time. As no disease-specific biomarker or histological finding is currently availa...
Source: Gut and Liver - April 19, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Clinicopathologic Features of Submucosal Papillary Gastric Cancer Differ from Those of Other Differentiated-Type Histologies.
Conclusions: SM papillary GC had the highest LNM rate, with features different from those of other differentiated SM invasive GCs. The treatment strategy for SM papillary GC should be carefully approached, especially for lesions located in the lower third or of the elevated gross type. PMID: 32295332 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 17, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Prognostic Factors for Patients with Borderline Resectable or Locally Advanced Pancreatic Cancer Receiving Neoadjuvant FOLFIRINOX.
Authors: Choi YH, Lee SH, You MS, Shin BS, Paik WH, Ryu JK, Kim YT, Kwon W, Jang JY, Kim SW Abstract Background/Aims: There has been growing evidence on the utility of neoadjuvant FOLFIRINOX in borderline resectable (BR) or locally advanced (LA) pancreatic cancer. However, factors predicting survival in these patients remain to be identified, and we aimed to identify these prognostic factors. Methods: Between January 2013 and April 2017, patients with BR or LA pancreatic cancer who received FOLFIRINOX as their initial treatment were identified. Demographic data and clinical outcomes, including the chemotherapy ...
Source: Gut and Liver - April 3, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Serum Insulin-Like Growth Factor Binding Protein 7 for Esophagogastric Junction Adenocarcinoma Diagnosis.
Authors: Zhang GM, Zhang GM, Zhang JH PMID: 32213664 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - March 28, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Image-Enhanced Endoscopy and Its Corresponding Histopathology in the Stomach.
Authors: Doyama H, Nakanishi H, Yao K Abstract In recent years, the technological innovation and progress of endoscopic equipment have been remarkable, and various endoscopic observation techniques have been developed. Among them, representative techniques are magnified observation and narrow-band imaging. Magnifying endoscopy with narrow-band imaging (M-NBI) can visualize superficial microanatomies in the stomach. The normal morphology of the microanatomy visualized using M-NBI differs according to the part of the stomach. The vessel plus surface (VS) classification system has been developed as a diagnostic criter...
Source: Gut and Liver - March 24, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Metachronous Gastric Cancer: Another Hurdle for Successful Endoscopic Treatment for Early Gastric Cancer?
Authors: Lee MW, Kim GH PMID: 32172548 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - March 17, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Awareness and Access to Therapy in Hepatitis C Virus Infected Patients, Key Barriers to Eliminate the Virus?
Authors: Kim DY PMID: 32172549 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - March 17, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Sarcopenia Is Independently Associated with the Degree of Liver Fibrosis in Patients with Type 2 Diabetes Mellitus.
Authors: Sung MJ, Lim TS, Jeon MY, Lee HW, Kim BK, Kim DY, Ahn SH, Han KH, Park JY, Kim SU Abstract Background/Aims: Sarcopenia is associated with liver fibrosis in patients with nonalcoholic fatty liver disease and chronic hepatitis B. We investigated the association between sarcopenia and hepatic fibrotic burden in patients with type 2 diabetes mellitus (T2DM). Methods: Patients with T2DM who had received a comprehensive medical health check-up were recruited. Muscle mass was assessed using computed tomography. Fibrotic burden was assessed using the fibrosis-4 index (FIB-4). The study population was divided by qu...
Source: Gut and Liver - March 7, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Systematic Review with Meta-Analysis: Low-Level Alcohol Consumption and the Risk of Liver Cancer.
Authors: Park H, Shin SK, Joo I, Song DS, Jang JW, Park JW Abstract Background/Aims: Multiple meta-analyses and observational studies have reported that alcohol is a risk factor for liver cancer. However, whether there is a safe level of alcohol consumption remains unclear. We performed a systematic review and meta-analysis of the correlation between low-level alcohol consumption and the risk of liver cancer. Methods: Nested case-control studies and cohort studies involving the general population published prior to July 2019 were searched. In total, 28 publications (31 cohorts) with 4,899 incident cases and 10,859 ...
Source: Gut and Liver - March 7, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Expanding Indications for Liver Transplant: Tumor and Patient Factors.
Authors: Chu KK, Wong KH, Chok KS Abstract During the past few decades, liver transplant has developed from a high-mortality procedure to an almost routine procedure with good survival outcomes. The development of living donor liver transplant has increased the availability of liver grafts, and the scope of indications for liver transplant has been expanding ever since. The aim of this review is to provide an overview of such an expansion of scope. Various criteria have been proposed to expand the eligibility of patients with hepatocellular carcinoma exceeding the Milan criteria for liver transplant. Furthermore, l...
Source: Gut and Liver - February 28, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Expression of Chemokine CCL28 in Ulcerative Colitis Patients.
Authors: Lee DS, Lee KL, Jeong JB, Shin S, Kim SH, Kim JW Abstract Background/Aims: Ulcerative colitis (UC) is an inflammatory bowel disease for which new serological markers are required. The purpose of this study was to assess the role of the mucosa-associated epithelial chemokine CCL28 in UC. Methods: The study included 50 patients; of these, 25 were patients with UC, and 25 were healthy controls. The levels of serum CCL28 were analyzed using enzyme-linked immunosorbent assay. CCL28 expression was analyzed by immunohistochemistry (IHC) in 15 representative colon tissues biopsied based on disease activity (UC pat...
Source: Gut and Liver - February 28, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Diagnostic Performance of Serum Asialo α1-Acid Glycoprotein Levels to Predict Liver Cirrhosis.
Diagnostic Performance of Serum Asialo α1-Acid Glycoprotein Levels to Predict Liver Cirrhosis. Gut Liver. 2020 Feb 20;: Authors: Lim DH, Kim M, Jun DW, Kwak MJ, Yoon JH, Lee KN, Lee HL, Lee OY, Yoon BC, Choi HS, Kang BK Abstract Background/Aims: To date, studies on various noninvasive techniques have been suggested to evaluate the degree of liver fibrosis. We aimed to investigate the diagnostic performance of serum asialo α1-acid glycoprotein (AsAGP) in the diagnosis of liver cirrhosis compared with chronic hepatitis for clinically useful result. Methods: We conducted a case-control study o...
Source: Gut and Liver - February 20, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

A Survey of the Knowledge of and Testing Rate for Hepatitis C in the General Population in South Korea.
Conclusions: The level of knowledge of HCV is suboptimal, and the self-reported testing rate for HCV is less than 10%; however, once HCV infection is diagnosed, the treatment rate seems to be high in South Korea. More active campaigns and effective screening are needed. PMID: 32066209 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - February 20, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Hepatic Steatosis Index in the Detection of Fatty Liver in Patients with Chronic Hepatitis B Receiving Antiviral Therapy.
Authors: Chang JW, Lee HW, Kim BK, Park JY, Kim DY, Ahn SH, Han KH, Kim SU Abstract Background/Aims: The hepatic steatosis index (HSI) is a noninvasive method to assess the severity of hepatic steatosis. Antiviral therapy (AVT) can impact aspartate aminotransferase and alanine aminotransferase levels, which are the main components of the HSI. Thus, we investigated the accuracy of the HSI in detecting hepatic steatosis in patients with chronic hepatitis B (CHB) receiving AVT, compared with those not receiving AVT and in those with nonalcoholic fatty liver disease (NAFLD). Methods: Patients with CHB or NAFLD who unde...
Source: Gut and Liver - February 20, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Long-term Prognosis of Localized Lymphoid Hyperplasia of the Rectum.
Conclusions: LLH of the rectum with persistent symptoms or the endoscopic appearance of the nodular or SMT-like type may lead to clinically significant disease. Risk stratification according to endoscopic findings and careful surveillance are required for these lesions. PMID: 32062874 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - February 19, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

The Modified Response Evaluation Criteria in Solid Tumors (RECIST) Yield a More Accurate Prognoses Than the RECIST 1.1 in Hepatocellular Carcinoma Treated with Transarterial Radioembolization.
Conclusions: Response evaluations that use the mRECIST provide more accurate prognoses than those that use the RECIST 1.1 in HCC patients treated with TARE. PMID: 32050313 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - February 15, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Impact of the Sensitivity to Empiric Antibiotics on Clinical Outcomes after Biliary Drainage for Acute Cholangitis.
Conclusions: Sensitivity of empiric antibiotics was not associated with clinical outcomes in acute cholangitis. PMID: 32050314 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - February 15, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Change in Portal Pressure and Clinical Outcome in Cirrhotic Patients with Gastric Varices after Plug-Assisted Retrograde Transvenous Obliteration.
Authors: Park JW, Yoo JJ, Kim SG, Jeong SW, Jang JY, Lee SH, Kim HS, Lee JM, Shim JJ, Kim YD, Cheon GJ, Jun BG, Kim YS Abstract Background/Aims: Plug-assisted retrograde transvenous obliteration (PARTO) is widely used to manage gastric varices with a portosystemic shunt. It is not clear whether portal pressure and the incidence of complications increase after PARTO. The aim of this study was to determine the changes in portal pressure and the associated changes in liver function, ascites, hepatic encephalopathy, and especially esophageal varix (EV) after PARTO. Methods: From March 2012 to February 2018, 54 patients...
Source: Gut and Liver - February 15, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Associated Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Registry: What Have We Learned?
Authors: Lang H, Baumgart J, Mittler J Abstract In 2007, the first associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure was performed in Regensburg, Germany. ALPPS is a variation of two-stage hepatectomy to induce rapid liver hypertrophy allowing the removal of large tumors otherwise considered irresectable due to a too small future liver remnant. In 2012, the international ALPPS registry was created, and it now contains more than 1,000 cases. During the past years, improved patient selection and refinements in operative techniques, in particular, less invasive approaches su...
Source: Gut and Liver - February 12, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Utility of Contrast-Enhanced Harmonic Endoscopic Ultrasound for the Guidance and Monitoring of Endoscopic Radiofrequency Ablation.
Conclusions: The application of CEH-EUS for RFA could be helpful in assessing early treatment response after ablation and targeting residual viable tumors during additional ablation sessions. PMID: 32000466 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - February 2, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Clinical Factors to Predict the Response to Concurrent Chemoradiotherapy and Survival in Esophageal Cancer Patients.
Conclusions: Advanced stage disease, poor performance status, male sex, and circumferential involvement were independent predictive factors for a poor response to CCRT. Advanced stage, poor performance status, and poor CCRT response were independent factors for decreased survival. PMID: 32000467 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - February 2, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Real-Life Effectiveness and Safety of Sofosbuvir-Based Therapy in Genotype 2 Chronic Hepatitis C Patients in South Korea, with Emphasis on the Ribavirin Dose.
Conclusions: SOF-based therapy showed high real-life efficacy and tolerability in Korean patients with genotype 2 chronic HCV infection, regardless of previous antiviral treatment experience and fibrosis score. A reduced ribavirin dose can be considered in this patient cohort. PMID: 32000468 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - February 2, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Difficult Biliary Cannulation from the Perspective of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: Identifying the Optimal Timing for the Rescue Cannulation Technique.
Conclusions: Biliary cannulation time and inadvertent PD manipulation could be relevant indicators of PEP, and 5 minutes might be used as a cutoff value for the implementation of the rescue cannulation technique. PMID: 32000469 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - February 2, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

The Influence of Family History on Stage and Survival of Gastric Cancer According to the TGFB1 C-509T Polymorphism in Korea.
Conclusions: Patient with a FH of GC had lower cancer stage (I-II) at diagnosis than those without a FH of GC, but there was no significant difference in overall survival between the patients with and without a FH of GC. A FH did not influence the tumor stage or overall survival in patients stratified by the presence of the TGFB1 C-509T polymorphism. PMID: 31905487 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - January 9, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Precision Medicine Approaches to Prevent Gastric Cancer.
Authors: Matsuzaki J, Tsugawa H, Suzuki H Abstract Gastric cancer remains one of the most common causes of cancer-related death worldwide, although the incidence is declining gradually. The primary risk factor for gastric cancer is Helicobacter pylori infection. The Kyoto global consensus report recommends eradication of H. pylori in all infected patients. However, because it is difficult to stratify the risk of carcinogenesis among patients with a history of H. pylori infection, annual endoscopic surveillance is performed for everyone after eradication. This review summarizes the current approaches used to screen ...
Source: Gut and Liver - January 4, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Helicobacter pylori Eradication Can Reverse the Methylation-Associated Regulation of miR-200a/b in Gastric Carcinogenesis.
Conclusions: Epigenetic alterations of miR-200a/b may be implicated in H. pylori-induced gastric carcinogenesis. This field defect for cancerization is suggested to be improved by H. pylori eradication. PMID: 31887809 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - December 31, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Efficacy of Current Traction Techniques for Endoscopic Submucosal Dissection.
Conclusions: Although the efficacy is dependent on the organ and tumor locations, several traction techniques have been demonstrated to be efficacious in facilitating ESD by maintaining satisfactory traction during dissection. PMID: 31887810 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - December 31, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Characteristic Features of Nonalcoholic Fatty Liver Disease in Japan with a Focus on the Roles of Age, Sex and Body Mass Index.
Authors: Tobari M, Hashimoto E Abstract This review provides an update on the characteristics of nonalcoholic fatty liver disease (NAFLD), with a focus on the effects of age, sex, and body mass index. Age is a risk factor for NAFLD progression; however, extremely old patients have unique features, namely, the associations between metabolic comorbidities and NAFLD are weaker and NAFLD is not a risk factor for mortality. The prevalence of NAFLD is higher in men than in premenopausal women, whereas the reverse is true after menopause. Thus, before menopause, estrogen may have protective effects against NAFLD. Our hosp...
Source: Gut and Liver - December 31, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Helicobacter pylori Treatment Strategies in Singapore.
Authors: Ang TL, Ang D Abstract The management of Helicobacter pylori infection in Singapore remains a clinical challenge. Similar to other regions, there has been an increase in antibiotic resistance rates through the years. Nonetheless, over the past two decades, clarithromycin-based triple therapy has continued to be used as the first line treatment option, with an eradication rate exceeding 90%, although the accepted treatment duration must now be lengthened from one to two weeks to maintain efficacy. Concomitant and sequential therapies did not demonstrate superiority over standard triple therapy. Current empi...
Source: Gut and Liver - December 28, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Prevalence, Awareness, and Treatment of Hepatitis C Virus Infection in South Korea: Evidence from the Korea National Health and Nutrition Examination Survey.
Conclusions: The prevalence of anti-HCV among Koreans aged ≥20 years was 0.71%; one-third of anti-HCV-positive persons tested HCV RNA-positive. The awareness and treatment rates of HCV infection were low among HCV-infected persons. Therefore, active measures should be taken to diagnose and treat persons unaware of HCV infection. PMID: 31842525 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - December 18, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Endoscopic Diagnosis of Nonpedunculated Dysplasia during Surveillance of Ulcerative Colitis: A Survey-Based Multinational Study.
Conclusions: Diagnostic performance based on the endoscopist's intention to perform a biopsy for nonpedunculated potentially dysplastic lesions in UC patients was suboptimal according to this survey-based study. PMID: 31842526 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - December 18, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Serum Insulin-Like Growth Factor Binding Protein 7 as a Potential Biomarker in the Diagnosis and Prognosis of Esophagogastric Junction Adenocarcinoma.
This study explored the diagnostic value of insulin-like growth factor binding protein 7 (IGFBP7) in EJA. Methods: A total of 120 EJA patients and 88 normal controls were recruited, and their serum levels of IGFBP7 were measured by enzyme-linked immunosorbent assay. Receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic value, and Pearson chi-square analysis was used to evaluate the correlation between IGFBP7 and clinical parameters. Kaplan-Meier survival analysis was carried out to assess the effect of IGFBP7 on overall survival (OS). Results: The levels of IGFBP7 were higher in b...
Source: Gut and Liver - December 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Strategies to Improve Persistent Adherence in Colorectal Cancer Screening.
Authors: Kew GS, Koh CJ Abstract Colorectal cancer is a major cause of morbidity and mortality, and screening has been shown to reduce morbidity and mortality. This review highlights pertinent aspects of adherence to screening including the various options available and key concepts to consider in any systematic program. Persistent adherence, which is key to an efficacious screening program, is the compliance with repeated screening tests over a period of time. A "chain of survival" mindset emphasizes the stepwise, sequential and persistent approach to screening and is a helpful concept to drive the messa...
Source: Gut and Liver - December 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Recent 5-Year Trend of Endoscopic Retrograde Cholangiography in Korea Using National Health Insurance Review and Assessment Service Open Data.
Authors: Park JM, Kang CD, Lee JC, Hwang JH, Kim J Abstract Background/Aims: The utilization of endoscopic retrograde cholangiopancreatography (ERCP) is variable and largely dependent on a patient's age, sex, and region. Herein we analyzed the publicly available Health Insurance Review and Assessment (HIRA) database with the aim of understanding the current status and trend of ERCP use in Korea. Methods: Between 2013 and 2017, information regarding ERCP was acquired from the HIRA database using the procedural codes of the Korean Standard Classification of Disease. We analyzed the annual number of patients accor...
Source: Gut and Liver - December 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Efficacy and Safety of Ghrelin Agonists in Patients with Diabetic Gastroparesis: A Systematic Review and Meta-Analysis.
Conclusions: Compared with placebo, ghrelin agonists are effective and well-tolerated for the treatment of DG. PMID: 31816671 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - December 11, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Child-Pugh B or C Cirrhosis Increases the Risk for Bleeding Following Colonoscopic Polypectomy.
Authors: Soh H, Chun J, Hong SW, Park S, Lee YB, Lee HJ, Cho EJ, Lee JH, Yu SJ, Im JP, Kim YJ, Kim JS, Yoon JH Abstract Background/Aims: The risk for colonoscopic postpolypectomy bleeding (PPB) in patients with chronic liver disease (CLD) remains unclear. We determined the incidence and risk factors for colonoscopic PPB in patients with CLD, especially those with liver cirrhosis. Methods: We retrospectively reviewed the medical records of patients with CLD who underwent colonoscopic polypectomy at Seoul National University Hospital between 2011 and 2014. The study endpoints were immediate and delayed PPB. R...
Source: Gut and Liver - December 11, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research