Interleukin-22 Attenuates Acute Pancreatitis-Associated Intestinal Mucosa Injury in Mice via STAT3 Activation.
Conclusions: Exogenous rIL-22 attenuates L-arginine-induced acute pancreatitis and intestinal mucosa injury in mice, via activating STAT3 signaling pathway and enhancing the expression of antimicrobial peptides and antiapoptotic genes. PMID: 33495423 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - January 28, 2021 Category: Gastroenterology Tags: Gut Liver Source Type: research

Evidence-Based Guidelines for the Treatment of Helicobacter pylori Infection in Korea 2020.
Authors: Jung HK, Kang SJ, Lee YC, Yang HJ, Park SY, Shin CM, Kim SE, Lim HC, Kim JH, Nam SY, Shin WG, Park JM, Choi IJ, Kim JG, Choi M, Korean College of Helicobacter and Upper Gastrointesinal Research Abstract Helicobacter pylori infection is one of the most common infectious diseases worldwide. Although the prevalence of H. pylori is gradually decreasing, approximately half of the world's population still becomes infected with this disease. H. pylori is responsible for substantial gastrointestinal morbidity worldwide, with a high disease burden. It is the most common cause of gastric and duodenal ulcers and...
Source: Gut and Liver - January 22, 2021 Category: Gastroenterology Tags: Gut Liver Source Type: research

Long-term Outcomes and Factors Affecting the Survival of Patients with Mucosal Esophageal Squamous Cell Carcinoma.
This study investigated the long-term outcomes and factors affecting the survival of patients with mucosal esophageal squamous cell carcinoma (T1aESCC). Methods: We analyzed the clinical and tumor-specific parameters of 263 patients who received surgical resection (SR; n=63) or endoscopic resection (ER; n=200) for T1aESCC. Underlying comorbidities were scored using the Charlson Comorbidity Index (CCI). Overall survival (OS) was the primary outcome, and multivariate regression analysis was performed to predict factors for OS. Results: Of the study patients (age, 64.5±8.0 years), the CCI was 1.0±1.4 in ...
Source: Gut and Liver - January 21, 2021 Category: Gastroenterology Tags: Gut Liver Source Type: research

Clinical Characteristics and Long-term Prognosis of Elderly-Onset Ulcerative Colitis in a Population-Based Cohort in the Songpa- Kangdong District of Seoul, Korea.
Conclusions: In this population-based study from Korea, the pattern of medication use seemed comparable between the EOUC and N-EOUC groups. Moreover, patients with EOUC and those with N-EOUC have a similar disease course in terms of proximal disease extension, hospitalization, and colectomy. PMID: 33462161 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - January 21, 2021 Category: Gastroenterology Tags: Gut Liver Source Type: research

Fecal Microbiota Transplantation Is Effective for the Treatment of Partially Treated Clostridioides difficile Infection.
Authors: Cho YS PMID: 33443235 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - January 15, 2021 Category: Gastroenterology Tags: Gut Liver Source Type: research

Corrigendum: Unmet Psychosocial Needs of Patients Newly Diagnosed with Ulcerative Colitis: Results from the Nationwide Prospective Cohort Study in Korea.
Authors: Moon JR, Lee CK, Hong SN, Im JP, Ye BD, Cha JM, Jung SA, Lee KM, Park DI, Jeen YT, Park YS, Cheon JH, Kim H, Seo B, Kim Y, Kim HJ, MOSAIK study group of the Korean Association for the Study of Intestinal Diseases (KASID) PMID: 33443236 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - January 15, 2021 Category: Gastroenterology Tags: Gut Liver Source Type: research

Clinical and Histologic Features of Patients with Biopsy-Proven Metabolic Dysfunction-Associated Fatty Liver Disease.
Conclusions: The novel diagnostic criteria for MAFLD include an additional 38.9% of patients with hepatic steatosis and can better help identify those with a high degree of disease severity for early intervention than can the previous NAFLD criteria. PMID: 33431715 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - January 14, 2021 Category: Gastroenterology Tags: Gut Liver Source Type: research

Gastrointestinal and Nongastrointestinal Complications of Esophagogastroduodenoscopy and Colonoscopy in the Real World: A Nationwide Standard Cohort Using the Common Data Model Database.
Authors: Kim HI, Yoon JY, Kwak MS, Cha JM Abstract Background/Aims: The global trend of an expanding aged population has increased concerns about complications correlated with gastrointestinal (GI) endoscopy in elderly patients; however, there have been few reports published on this issue. Methods: In this retrospective, observational cohort study performed between 2012 and 2017, serious complications of esophagogastroduodenoscopy (EGD), colonoscopy, and colonoscopic polypectomy were compared between patients according to age (≥65 years vs 18–64 years). We used the Health Insurance Review and Assessmen...
Source: Gut and Liver - January 8, 2021 Category: Gastroenterology Tags: Gut Liver Source Type: research

Four-Step Classification of Endoscopic Transpapillary Gallbladder Drainage and the Practical Efficacy of Cholangioscopic Assistance.
Conclusions: Optional SG-ETGBD achieved a significantly higher success rate than C-ETGBD alone. Step classification is helpful for determining the technical difficulty of ETGBD and developing a theoretical strategy to apply cholangioscopy in a coordinated manner. PMID: 33402544 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - January 8, 2021 Category: Gastroenterology Tags: Gut Liver Source Type: research

Types of 23S Ribosomal RNA Point Mutations and Therapeutic Outcomes for Helicobacter pylori.
This study aimed to detect the prevalence of these point mutations and to investigate the role of different point mutations in the success of eradication therapy. Methods: We retrospectively investigated a total of 464 consecutive patients who underwent an endoscopic examination and dual-priming oligonucleotide-based multiplex polymerase chain reaction for H. pylori between June 2014 and October 2019. For 289 patients with negative point mutations, standard triple therapy was used in 287 patients, and the bismuth-quadruple regimen was used in two patients. For 175 patients with positive point mutations (A2142G, A2143G,...
Source: Gut and Liver - January 1, 2021 Category: Gastroenterology Tags: Gut Liver Source Type: research

Deep Neural Network-Based Predication of the Risk of Advanced Colorectal Neoplasia.
Authors: Min JK, Yang HJ, Kwak MS, Cho CW, Kim S, Ahn KS, Park SK, Cha JM, Park DI Abstract Background/Aims: Risk prediction models using a deep neural network (DNN) have not been reported to predict the risk of advanced colorectal neoplasia (ACRN). The aim of this study was to compare DNN models with simple clinical score models to predict the risk of ACRN in colorectal cancer screening. Methods: Databases of screening colonoscopy from Kangbuk Samsung Hospital (n=121,794) and Kyung Hee University Hospital at Gangdong (n=3,728) were used to develop DNN-based prediction models. Two DNN models, the Asian-Pacific ...
Source: Gut and Liver - January 1, 2021 Category: Gastroenterology Tags: Gut Liver Source Type: research

Anti-Saccharomyces cerevisiae Antibody in Pediatric Crohn's Disease Patients without Mucosal Healing Is a Useful Marker of Mucosal Damage.
This study included 61 CD patients aged 19 years or younger who were diagnosed and treated between September 2010 and January 2019 and followed for at least 1 year. ASCA was regularly measured at the diagnosis of CD and at least 1 year after IFX therapy. Results: The average follow-up period was 3.8±3.4 years (range, 1.0 to 7.2 years). Regression analysis showed that the ASCA titer was the only factor associated with Simple Endoscopic Score for Crohn's Disease (SES-CD) or CR among all the parameters. In patients who had achieved MH (SES-CD=0), ASCA immunoglobulin G (IgG) was not associated with MH, but in p...
Source: Gut and Liver - January 1, 2021 Category: Gastroenterology Tags: Gut Liver Source Type: research

Histopathological Analysis of Esophageal Mucosa in Patients with Achalasia.
Authors: Lee BE, Kim GH, Shin N, Park DY, Song GA Abstract Background/Aims: Achalasia is an esophageal motor disorder that leads to functional esophageal obstruction. Food stasis and bacterial fermentation can predispose an individual to esophageal mucosal inflammation, causing multifocal dysplasia and increasing the risk of developing esophageal squamous cell carcinoma. We aimed to evaluate esophageal mucosal alterations in achalasia patients and determine clinical factors associated with the histopathological findings. Methods: From 2009 to 2013, we obtained endoscopic biopsies from the lower and middle esoph...
Source: Gut and Liver - December 29, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Risk Factors for Acute Cholangitis Caused by Enterococcus faecalis and Enterococcus faecium.
Conclusions: Given the intrinsic resistance of E. faecalis and E. faecium to antibiotics, clinicians should consider empirical therapy with anti-enterococcal antibiotics for patients with prior EST. PMID: 33361547 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - December 29, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Risk Stratification of T1 Colorectal Cancer Metastasis to Lymph Nodes: Current Status and Perspective.
Authors: Ichimasa K, Kudo SE, Miyachi H, Kouyama Y, Misawa M, Mori Y Abstract With the widely spreading population-based screening programs for colorectal cancer and recent improvements in endoscopic diagnosis, the number of endoscopic resections in subjects with T1 colorectal cancer has been increasing. Some reports suggest that endoscopic resection prior to surgical resection of T1 colorectal cancer has no adverse effect on prognosis and contributes to this tendency. The decision on the need for surgical resection as an additional treatment after endoscopic resection of T1 colorectal cancer should be made accordi...
Source: Gut and Liver - December 29, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Diagnostic Accuracy of Fecal Calprotectin for the Detection of Small Bowel Crohn's Disease through Capsule Endoscopy: An Updated Meta-analysis and Systematic Review.
Conclusions: FC has significant diagnostic accuracy for detecting small bowel inflammation, and an FC cutoff of 100 µg/g can be used as a tool to screen for small bowel Crohn's disease. PMID: 33361549 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - December 29, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Direct Bilirubin Is More Valuable than Total Bilirubin for Predicting Prognosis in Patients with Liver Cirrhosis.
This study investigated prognostic performance of serum direct bilirubin (DB) and developed new DB level-based prediction models for cirrhosis. Methods: A total of 983 hospitalized patients with liver cirrhosis were included. DB-Model for End-Stage Liver Disease (MELD) score was calculated using MELD score formula, with serum DB level replacing TB level. Results: Mean age of study population was 56.1 years. Alcoholic liver disease was the most frequent underlying condition (471 patients, 47.9%). Within 6 months, 144 patients (14.6%) died or received liver transplantation due to severe liver dysfunction. The area un...
Source: Gut and Liver - December 10, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Clinical Significance of TWIST-Positive Circulating Tumor Cells in Patients with Esophageal Squamous Cell Carcinoma.
Conclusions: Our study showed that TWIST (+) CTCs were frequently detected in patients with ESCC, and a high proportion of TWIST (+) CTCs was associated with poor differentiation. PMID: 33293482 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - December 10, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Efficacy of Tegoprazan for Improving the Susceptibility of Antimicrobial Agents against Antibiotic-Resistant Helicobacter pylori.
Conclusions: Tegoprazan administration may improve the susceptibility of antimicrobial- resistant H. pylori, independent of acid suppression. PMID: 33191308 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - November 18, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Selecting the Right Tool for the Right Job: Which Response Criteria Better Predicts Survival of Patients Treated with Transarterial Radioembolization?
Authors: Kim BH PMID: 33191309 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - November 18, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Biologics for the Management of Inflammatory Bowel Disease: A Review in Tuberculosis-Endemic Countries.
Authors: Banerjee R, Ali RAR, Wei SC, Adsul S Abstract The advent of biologics and biologic therapy has transformed the management of inflammatory bowel disease (IBD) with enhanced early and adequate responses to treatment, fewer hospitalizations, a reduced need for surgery, and unprecedented outcomes including complete mucosal and histologic healing. However, an important issue with the use of anti-tumor necrosis factor (anti-TNF) agents in IBD is the increased risk of tuberculosis (TB). This is compounded by the diagnostic dilemma when differentiating between Crohn's disease and gastrointestinal TB, and the poten...
Source: Gut and Liver - November 18, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Clinical Guidelines for Drug-Related Peptic Ulcer, 2020 Revised Edition.
Authors: Joo MK, Park CH, Kim JS, Park JM, Ahn JY, Lee BE, Lee JH, Yang HJ, Cho YK, Bang CS, Kim BJ, Jung HK, Kim BW, Lee YC, Korean College of Helicobacter Upper Gastrointestinal Research Abstract Korean guidelines for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcer were previously developed in 2009 with the collaboration of the Korean College of Helicobacter and Upper Gastrointestinal Research and Korean Society of Gastroenterology. However, the previous guidelines were based mainly upon a review of the relevant literature and expert opinion. Therefore, the guidelines need to be revised. We organ...
Source: Gut and Liver - November 18, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Pain Intensity at Injection Site during Esophagogastroduodenoscopy Using Long- and Medium-Chain versus Long-Chain Triglyceride Propofol: A Randomized Controlled Double-Blind Study.
This study was a single-center, randomized, controlled, and double-blind trial. Pain intensity was estimated 30 seconds after propofol injection by an examiner who was blinded to the group assignment using a numeric (0–10) pain rating scale (NPRS). After 1 week, the patients were asked whether they could recall the pain and were willing to receive the same agent for their next EGD. Results: One hundred twenty-nine patients were randomly assigned to LCT/MCT or LCT group. Although there was no significant difference in pain incidence between the LCT/ MCT and LCT groups (52.9% vs 65.6%, p=0.156), the pain intensity ...
Source: Gut and Liver - October 30, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Partial Virological Response after 2 Years of Entecavir Therapy Increases the Risk of Hepatocellular Carcinoma in Patients with Hepatitis B Virusassociated Cirrhosis.
This study investigated whether PVR after 2 years of entecavir (ETV) therapy is associated with hepatocellular carcinoma (HCC) development in cirrhotic patients. Methods: A total of 472 naïve patients with hepatitis B virus (HBV)-associated cirrhosis who were treated with ETV for at least 2 years were retrospectively enrolled. Clinical characteristics, laboratory data, PVR, and noninvasive fibrosis markers (aspartate aminotransferase to platelet ratio and FIB-4 index) at 2 years after ETV commencement were analyzed for HCC risk. Results: After excluding those who developed HCC within 2 years of ETV therapy, 35...
Source: Gut and Liver - October 30, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Factors Associated with Clinical Outcomes of Palliative Stenting for Malignant Colonic Obstruction.
Conclusions: In patients requiring palliative stenting for MCO, peritoneal carcinomatosis was associated with both clinical failure and short RFS. Stent expansion>90% on postprocedural day 1 was another predictor of a short RFS after clinically successful stenting. A large prospective study is warranted to establish factors associated with RFS after successful palliative stenting for MCO. PMID: 33115967 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - October 30, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

The Usefulness of the Measurement of Esophagogastric Junction Distensibility by EndoFLIP in the Diagnosis of Gastroesophageal Reflux Disease.
Authors: Lee JM, Yoo IK, Kim E, Hong SP, Cho JY Abstract Background/Aims: : Increased esophagogastric junction (EGJ) relaxation is the most important mechanism involved in gastroesophageal reflux disease (GERD). An endoscopic functional luminal imaging probe (EndoFLIP®) is a device used to quantify EGJ distensibility in routine endoscopy. The aim of the current study was to assess the usefulness of EndoFLIP® for the diagnosis of GERD compared to normal controls. Methods: We analyzed EndoFLIP® data from 204 patients with erosive reflux disease (ERD), 310 patients with nonerosive reflux disease (NERD)...
Source: Gut and Liver - October 30, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Tumor-Associated Macrophages in Hepatocellular Carcinoma: Friend or Foe?
Authors: Zhou D, Luan J, Huang C, Li J Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, and it has diverse etiologies with multiple mechanisms. The diagnosis of HCC typically occurs at advanced stages when there are limited therapeutic options. Hepatocarcinogenesis is considered a multistep process, and hepatic macrophages play a critical role in the inflammatory process leading to HCC. Emerging evidence has shown that tumor-associated macrophages (TAMs) are crucial components defining the HCC immune microenvironment and represent an appealing option for disrupting the forma...
Source: Gut and Liver - October 23, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Puzzle and Challenge in Routine Extrahepatic Bile Duct Resection for Advanced Gallbladder Carcinoma.
Authors: Liu F, Li FY PMID: 33055359 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - October 20, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

A Nationwide Cohort Study Shows a Sex-Dependent Change in the Trend of Peptic Ulcer Bleeding Incidence in Korea between 2006 and 2015.
This study aimed to investigate the trends in PUB incidence and the effect of risk factors on PUB in Korea. Methods: The records of patients hospitalized with PUB from 2006 to 2015 were retrieved from the Korean National Health Insurance Service Database. Standardized incidences of PUB were calculated, and the clinical characteristics such as age, sex, Helicobacter pylori infection, drug exposure, comorbidities, and mortality were obtained. Results: In total, 151,507 hospitalizations with PUB were identified. The overall annual hospitalization rate was 34.98 per 100,000 person-years. The incidence of PUB showed no ...
Source: Gut and Liver - October 20, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Leaky Gut and Gut-Liver Axis in Liver Cirrhosis: Clinical Studies Update.
Authors: Fukui H Abstract Portal blood flows into the liver containing the gut microbiome and its products such as endotoxin and bacterial DNA. The cirrhotic liver acts and detoxifies as the initial site of microbial products. In so-called "leaky gut," the increased intestinal permeability for bacteria and their products constitutes an important pathogenetic factor for major complications in patients with liver cirrhosis. Prolonged gastric and small intestinal transit may induce intestinal bacterial overgrowth, a condition in which colonic bacteria translocate into the small gut. Cirrhotic patients furthe...
Source: Gut and Liver - October 20, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Hereditary Fructose Intolerance Diagnosed in Adulthood.
Authors: Kim MS, Moon JS, Kim MJ, Seong MW, Park SS, Ko JS Abstract Hereditary fructose intolerance (HFI) is an autosomal recessive disorder caused by a mutation in the aldolase B gene. HFI patients exhibit nausea, vomiting, abdominal pain, hypoglycemia, and elevated liver enzymes after dietary fructose exposure. Chronic exposure might lead to failure to thrive, liver failure, renal failure, and, eventually, death. HFI usually manifests in infants when they are being weaned off of breastmilk. Because HFI has an excellent prognosis when patients maintain a strict restrictive diet, some patients remain undiagnosed du...
Source: Gut and Liver - October 10, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Technical and Clinical Aspects of Diagnostic Single-Balloon Enteroscopy in the First Decade of Use: A Systematic Review and Meta-Analysis.
Authors: Gao Y, Xin L, Zhang YT, Guo XR, Meng QQ, Li ZS, Liao Z Abstract Background/Aims: Single-balloon enteroscopy (SBE) has been widely used in diagnosing small bowel disease. We conducted this study to systematically appraise its technical and clinical performance. Methods: Studies on SBE published by September 2018 were systematically searched. Technical and clinical performance data were collected and analyzed with descriptive or meta-analysis methods. Results: In total, 54 articles incorporating 4,592 patients (6,036 procedures) were included. Regarding technical parameters, the pooled insertion dept...
Source: Gut and Liver - October 10, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Efficacy of Endoscopic Vacuum-Assisted Closure Treatment for Postoperative Anastomotic Leak in Gastric Cancer.
Authors: Choi SI, Park JC, Jung DH, Shin SK, Lee SK, Lee YC Abstract Background/Aims: Endoscopic vacuum-assisted closure (EVAC) has been attempted as new nonsurgical treatment for anastomotic leakage. We aimed to evaluate the clinical outcomes of EVAC and compare its efficacy with the self-expandable metallic stent (SEMS) for postgastrectomy leakage. Methods: Between January 2007 and February 2018, 39 patients underwent endoscopic treatment for anastomotic leakage after gastric cancer surgery. Of them, 28 patients were treated with SEMS, seven with EVAC after SEMS failure, and four with EVAC. We retrospectively...
Source: Gut and Liver - October 9, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Factors Associated with the Immunogenicity of Anti-Tumor Necrosis Factor Agents in Pediatric Patients with Inflammatory Bowel Disease.
Authors: Kim JY, Lee Y, Choe BH, Kang B Abstract Background/Aims: Anti-drug antibodies (ADAs) can develop during treatment with anti-tumor necrosis factor (TNF) agents. We aimed to investigate the factors associated with immunogenicity of anti-TNF agents in pediatric patients with inflammatory bowel disease (IBD) and observe the clinical course of ADA-positive patients. Methods: Pediatric IBD patients receiving maintenance treatment with anti-TNF agents who had been tested for ADAs against infliximab (IFX) or adalimumab (ADL) were included in this crosssectional study. Factors associated with ADA positivity wer...
Source: Gut and Liver - October 9, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Management of Gallstones and Acute Cholecystitis in Patients with Liver Cirrhosis: What Should We Consider When Performing Surgery?
Authors: Wang SY, Yeh CN, Jan YY, Chen MF Abstract Acute cholecystitis and several gallbladder stone-related conditions, such as impacted common bile duct stones, cholangitis, and biliary pancreatitis, are common medical conditions in daily practice. An early cholecystectomy or drainage procedure with delayed cholecystectomy is the current standard of treatment based on published clinical guidelines. Cirrhosis is not only a condition of chronically impaired hepatic function but also has systemic effects in patients. In cirrhotic individuals, several predisposing factors, including changes in the bile acid compositi...
Source: Gut and Liver - September 16, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Recent Epidemiology of Nonalcoholic Fatty Liver Disease.
Authors: Murag S, Ahmed A, Kim D Abstract The ongoing obesity epidemic and the increasing recognition of metabolic syndrome have contributed to the growing prevalence of nonalcoholic fatty liver disease (NAFLD), the most common form of liver disease worldwide. It is imperative to understand the incidence and prevalence of NAFLD as it is associated with a profound economic burden of hospitalizations, including the shifting trends in liver transplantation. The long-term cumulative healthcare cost of NAFLD patients has been shown to be 80% higher than that of non-NAFLD patients. We explore diagnostic challenges in ide...
Source: Gut and Liver - September 16, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Reversal of the Methylation-Associated Regulation of miR-200a/b by Helicobacter pylori Eradication Contributes to the Chemoprevention of Gastric Carcinogenesis.
Authors: Kim N PMID: 32921637 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - September 16, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

The Clinical Significance and Risk Factors of Colorectal Stricture in Ulcerative Colitis.
Authors: Park SC, Jeen YT PMID: 32921638 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - September 16, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Guidelines for Nonvariceal Upper Gastrointestinal Bleeding.
Authors: Kim JS, Kim BW, Kim DH, Park CH, Lee H, Joo MK, Jung DH, Chung JW, Choi HS, Baik GH, Lee JH, Song KY, Hur S Abstract Nonvariceal upper gastrointestinal bleeding (NVUGIB) refers to bleeding that develops in the gastrointestinal tract proximal to the ligament of Treitz. NVUGIB requires hospitalization and is associated with significant morbidity and mortality. Although European and Asian-Pacific guidelines have been published, there have been no previous guidelines regarding management of NVUGIB in Korea. Korea has a high prevalence of Helicobacter pylori infections, and patients have easy accessibility to e...
Source: Gut and Liver - September 16, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Independent Risk Factors for Hepatocellular Carcinoma Recurrence after Direct-Acting Antiviral Therapy in Patients with Chronic Hepatitis C.
This study was performed to evaluate the efficacy of direct-acting antivirals (DAAs) in Korean patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) and to investigate the risk factors associated with HCC recurrence. Methods: A total of 100 patients with HCV-related HCC, who were treated with DAAs between May 2015 and December 2016, were recruited from seven university hospitals in Korea. Claim data of 526 patients with HCC obtained from the Health Insurance Review and Assessment Service in South Korea were used for external validation of the results. Results: Among the 100 patients, 88% achi...
Source: Gut and Liver - September 8, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Comparison of Long-term Outcomes of Infliximab versus Adalimumab in 1,488 Biologic-Naive Korean Patients with Crohn's Disease.
Conclusions: In this nationwide population-based study, no significant difference was found in the long-term effectiveness of IFX and ADA in the real-world setting of biologic-naive Korean patients with CD. In the absence of trials to directly compare IFX and ADA, our study indicates that the selection of one of these two biologics can be determined by patient and/or physician preference. PMID: 32839359 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - August 27, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Comparison of Clinical Outcomes of Borderline Resectable Pancreatic Cancer According to the Neoadjuvant Chemo-Regimens: Gemcitabine versus FOLFIRINOX.
Authors: Choi YJ, Byun Y, Kang JS, Kim HS, Han Y, Kim H, Kwon W, Oh DY, Paik WH, Lee SH, Ryu JK, Kim YT, Lee K, Kim H, Chie EK, Jang JY Abstract Background/Aims: Although many studies have reported the promising effect of neoadjuvant treatment for borderline resectable pancreatic cancer (BRPC) to increase resectability, only a few studies have recommended the use of firstline chemotherapeutic agents as neoadjuvant treatment for BRPC. The current study compared clinical outcomes between gemcitabine and FOLFIRINOX (5-fluorouracil, leucovorin, oxaliplatin, and irinotecan) in patients with BRPC. Methods: In this si...
Source: Gut and Liver - August 27, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Clinical Significance of Residual Nonrectal Inflammation in Ulcerative Colitis Patients in Clinical Remission.
Conclusions: We suggest that escalation of treatment modalities may be selectively performed in consideration of the residual mucosal inflammation pattern, even if ER has not been achieved, in UC patients with CR. PMID: 32839361 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - August 27, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Change in the Recurrence Pattern and Predictors over Time after Complete Cure of Hepatocellular Carcinoma.
Authors: Lee HA, Lee YS, Kim BK, Jung YK, Kim SU, Park JY, Kim JH, An H, Kim DY, Yim HJ, Ahn SH, Yeon JE, Byun KS, Han KH, Um SH, Seo YS Abstract Background/Aims: We investigated changes in recurrence rates and significant recurrence predictors over time after complete cure of hepatocellular carcinoma (HCC). Methods: A total of 1,491 patients with first-time diagnosis of Barcelona Clinic Liver Cancer stage A HCC, completely cured by treatment between 2007 and 2016, were recruited from two Korean tertiary institutes. Results: The mean age of the population (1,144 men and 347 women) was 58.6 years. Of the tot...
Source: Gut and Liver - August 27, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Factors Related to Outcomes of Fecal Microbiota Transplantation in Patients with Clostridioides difficile Infection.
Conclusions: FMT is highly effective in partially treated CDI but not in refractory CDI. The microbiome differs between failed and successful cases. Frozen stock for FMT is viable up to 48 weeks. PMID: 32839363 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - August 27, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Colonoscopic Polypectomy Preferences of Asian Endoscopists: Results of a Survey-Based Study.
Conclusions: The polypectomy practice patterns of Asian endoscopists vary, and cold snare polypectomy was not the most preferred resection method for polyps
Source: Gut and Liver - August 27, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Real-Life Effectiveness and Safety of Glecaprevir/Pibrentasvir for Korean Patients with Chronic Hepatitis C at a Single Institution.
Conclusions: These real-life data indicated that G/P treatment was highly effective and well tolerated, regardless of viral genotype or patient comorbidities. PMID: 32839365 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - August 27, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Application of Artificial Intelligence in the Detection and Characterization of Colorectal Neoplasm.
Authors: Kim KO, Kim EY Abstract Endoscpists always have tried to pursue a perfect colonoscopy, and application of artificial intelligence (AI) using deep-learning algorithms is one of the promising supportive options for detection and characterization of colorectal polyps during colonoscopy. Many retrospective studies conducted with real-time application of AI using convolutional neural networks have shown improved colorectal polyp detection. Moreover, a recent randomized clinical trial reported additional polyp detection with shorter analysis time. Studies conducted regarding polyp characterization provided addit...
Source: Gut and Liver - August 14, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Contrast Harmonic-Enhanced Endoscopic Ultrasound (EUS) Is the Perfect Companion of EUS-Guided Tumor Ablation.
Authors: Marocchi G, Lisotti A, Fusaroli P PMID: 32773387 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - August 14, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Clinical Outcomes of Endoscopic Resection for Low-Grade Dysplasia and High-Grade Dysplasia on Gastric Pretreatment Biopsy: Korea ESD Study Group.
Conclusions: A substantial proportion of LGDs and HGDs on pretreatment FB were diagnosed as GC after ER. Accurate ER procedures such as endoscopic submucosal dissection should be recommended in cases of LGD and HGD with factors predicting pathologic upstaging to GC. PMID: 32773388 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - August 14, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research