Efficacy of Tegoprazan for Improving the Susceptibility of Antimicrobial Agents against Antibiotic-Resistant Helicobacter pylori.
Conclusions: Tegoprazan administration may improve the susceptibility of antimicrobial- resistant H. pylori, independent of acid suppression. PMID: 33191308 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - November 18, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Selecting the Right Tool for the Right Job: Which Response Criteria Better Predicts Survival of Patients Treated with Transarterial Radioembolization?
Authors: Kim BH PMID: 33191309 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - November 18, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Biologics for the Management of Inflammatory Bowel Disease: A Review in Tuberculosis-Endemic Countries.
Authors: Banerjee R, Ali RAR, Wei SC, Adsul S Abstract The advent of biologics and biologic therapy has transformed the management of inflammatory bowel disease (IBD) with enhanced early and adequate responses to treatment, fewer hospitalizations, a reduced need for surgery, and unprecedented outcomes including complete mucosal and histologic healing. However, an important issue with the use of anti-tumor necrosis factor (anti-TNF) agents in IBD is the increased risk of tuberculosis (TB). This is compounded by the diagnostic dilemma when differentiating between Crohn's disease and gastrointestinal TB, and the poten...
Source: Gut and Liver - November 18, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Clinical Guidelines for Drug-Related Peptic Ulcer, 2020 Revised Edition.
Authors: Joo MK, Park CH, Kim JS, Park JM, Ahn JY, Lee BE, Lee JH, Yang HJ, Cho YK, Bang CS, Kim BJ, Jung HK, Kim BW, Lee YC, Korean College of Helicobacter Upper Gastrointestinal Research Abstract Korean guidelines for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcer were previously developed in 2009 with the collaboration of the Korean College of Helicobacter and Upper Gastrointestinal Research and Korean Society of Gastroenterology. However, the previous guidelines were based mainly upon a review of the relevant literature and expert opinion. Therefore, the guidelines need to be revised. We organ...
Source: Gut and Liver - November 18, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Pain Intensity at Injection Site during Esophagogastroduodenoscopy Using Long- and Medium-Chain versus Long-Chain Triglyceride Propofol: A Randomized Controlled Double-Blind Study.
This study was a single-center, randomized, controlled, and double-blind trial. Pain intensity was estimated 30 seconds after propofol injection by an examiner who was blinded to the group assignment using a numeric (0–10) pain rating scale (NPRS). After 1 week, the patients were asked whether they could recall the pain and were willing to receive the same agent for their next EGD. Results: One hundred twenty-nine patients were randomly assigned to LCT/MCT or LCT group. Although there was no significant difference in pain incidence between the LCT/ MCT and LCT groups (52.9% vs 65.6%, p=0.156), the pain intensity ...
Source: Gut and Liver - October 30, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Partial Virological Response after 2 Years of Entecavir Therapy Increases the Risk of Hepatocellular Carcinoma in Patients with Hepatitis B Virusassociated Cirrhosis.
This study investigated whether PVR after 2 years of entecavir (ETV) therapy is associated with hepatocellular carcinoma (HCC) development in cirrhotic patients. Methods: A total of 472 naïve patients with hepatitis B virus (HBV)-associated cirrhosis who were treated with ETV for at least 2 years were retrospectively enrolled. Clinical characteristics, laboratory data, PVR, and noninvasive fibrosis markers (aspartate aminotransferase to platelet ratio and FIB-4 index) at 2 years after ETV commencement were analyzed for HCC risk. Results: After excluding those who developed HCC within 2 years of ETV therapy, 35...
Source: Gut and Liver - October 30, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Factors Associated with Clinical Outcomes of Palliative Stenting for Malignant Colonic Obstruction.
Conclusions: In patients requiring palliative stenting for MCO, peritoneal carcinomatosis was associated with both clinical failure and short RFS. Stent expansion>90% on postprocedural day 1 was another predictor of a short RFS after clinically successful stenting. A large prospective study is warranted to establish factors associated with RFS after successful palliative stenting for MCO. PMID: 33115967 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - October 30, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

The Usefulness of the Measurement of Esophagogastric Junction Distensibility by EndoFLIP in the Diagnosis of Gastroesophageal Reflux Disease.
Authors: Lee JM, Yoo IK, Kim E, Hong SP, Cho JY Abstract Background/Aims: : Increased esophagogastric junction (EGJ) relaxation is the most important mechanism involved in gastroesophageal reflux disease (GERD). An endoscopic functional luminal imaging probe (EndoFLIP®) is a device used to quantify EGJ distensibility in routine endoscopy. The aim of the current study was to assess the usefulness of EndoFLIP® for the diagnosis of GERD compared to normal controls. Methods: We analyzed EndoFLIP® data from 204 patients with erosive reflux disease (ERD), 310 patients with nonerosive reflux disease (NERD)...
Source: Gut and Liver - October 30, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Tumor-Associated Macrophages in Hepatocellular Carcinoma: Friend or Foe?
Authors: Zhou D, Luan J, Huang C, Li J Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, and it has diverse etiologies with multiple mechanisms. The diagnosis of HCC typically occurs at advanced stages when there are limited therapeutic options. Hepatocarcinogenesis is considered a multistep process, and hepatic macrophages play a critical role in the inflammatory process leading to HCC. Emerging evidence has shown that tumor-associated macrophages (TAMs) are crucial components defining the HCC immune microenvironment and represent an appealing option for disrupting the forma...
Source: Gut and Liver - October 23, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Puzzle and Challenge in Routine Extrahepatic Bile Duct Resection for Advanced Gallbladder Carcinoma.
Authors: Liu F, Li FY PMID: 33055359 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - October 20, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

A Nationwide Cohort Study Shows a Sex-Dependent Change in the Trend of Peptic Ulcer Bleeding Incidence in Korea between 2006 and 2015.
This study aimed to investigate the trends in PUB incidence and the effect of risk factors on PUB in Korea. Methods: The records of patients hospitalized with PUB from 2006 to 2015 were retrieved from the Korean National Health Insurance Service Database. Standardized incidences of PUB were calculated, and the clinical characteristics such as age, sex, Helicobacter pylori infection, drug exposure, comorbidities, and mortality were obtained. Results: In total, 151,507 hospitalizations with PUB were identified. The overall annual hospitalization rate was 34.98 per 100,000 person-years. The incidence of PUB showed no ...
Source: Gut and Liver - October 20, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Leaky Gut and Gut-Liver Axis in Liver Cirrhosis: Clinical Studies Update.
Authors: Fukui H Abstract Portal blood flows into the liver containing the gut microbiome and its products such as endotoxin and bacterial DNA. The cirrhotic liver acts and detoxifies as the initial site of microbial products. In so-called "leaky gut," the increased intestinal permeability for bacteria and their products constitutes an important pathogenetic factor for major complications in patients with liver cirrhosis. Prolonged gastric and small intestinal transit may induce intestinal bacterial overgrowth, a condition in which colonic bacteria translocate into the small gut. Cirrhotic patients furthe...
Source: Gut and Liver - October 20, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Hereditary Fructose Intolerance Diagnosed in Adulthood.
Authors: Kim MS, Moon JS, Kim MJ, Seong MW, Park SS, Ko JS Abstract Hereditary fructose intolerance (HFI) is an autosomal recessive disorder caused by a mutation in the aldolase B gene. HFI patients exhibit nausea, vomiting, abdominal pain, hypoglycemia, and elevated liver enzymes after dietary fructose exposure. Chronic exposure might lead to failure to thrive, liver failure, renal failure, and, eventually, death. HFI usually manifests in infants when they are being weaned off of breastmilk. Because HFI has an excellent prognosis when patients maintain a strict restrictive diet, some patients remain undiagnosed du...
Source: Gut and Liver - October 10, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Technical and Clinical Aspects of Diagnostic Single-Balloon Enteroscopy in the First Decade of Use: A Systematic Review and Meta-Analysis.
Authors: Gao Y, Xin L, Zhang YT, Guo XR, Meng QQ, Li ZS, Liao Z Abstract Background/Aims: Single-balloon enteroscopy (SBE) has been widely used in diagnosing small bowel disease. We conducted this study to systematically appraise its technical and clinical performance. Methods: Studies on SBE published by September 2018 were systematically searched. Technical and clinical performance data were collected and analyzed with descriptive or meta-analysis methods. Results: In total, 54 articles incorporating 4,592 patients (6,036 procedures) were included. Regarding technical parameters, the pooled insertion dept...
Source: Gut and Liver - October 10, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Efficacy of Endoscopic Vacuum-Assisted Closure Treatment for Postoperative Anastomotic Leak in Gastric Cancer.
Authors: Choi SI, Park JC, Jung DH, Shin SK, Lee SK, Lee YC Abstract Background/Aims: Endoscopic vacuum-assisted closure (EVAC) has been attempted as new nonsurgical treatment for anastomotic leakage. We aimed to evaluate the clinical outcomes of EVAC and compare its efficacy with the self-expandable metallic stent (SEMS) for postgastrectomy leakage. Methods: Between January 2007 and February 2018, 39 patients underwent endoscopic treatment for anastomotic leakage after gastric cancer surgery. Of them, 28 patients were treated with SEMS, seven with EVAC after SEMS failure, and four with EVAC. We retrospectively...
Source: Gut and Liver - October 9, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Factors Associated with the Immunogenicity of Anti-Tumor Necrosis Factor Agents in Pediatric Patients with Inflammatory Bowel Disease.
Authors: Kim JY, Lee Y, Choe BH, Kang B Abstract Background/Aims: Anti-drug antibodies (ADAs) can develop during treatment with anti-tumor necrosis factor (TNF) agents. We aimed to investigate the factors associated with immunogenicity of anti-TNF agents in pediatric patients with inflammatory bowel disease (IBD) and observe the clinical course of ADA-positive patients. Methods: Pediatric IBD patients receiving maintenance treatment with anti-TNF agents who had been tested for ADAs against infliximab (IFX) or adalimumab (ADL) were included in this crosssectional study. Factors associated with ADA positivity wer...
Source: Gut and Liver - October 9, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Management of Gallstones and Acute Cholecystitis in Patients with Liver Cirrhosis: What Should We Consider When Performing Surgery?
Authors: Wang SY, Yeh CN, Jan YY, Chen MF Abstract Acute cholecystitis and several gallbladder stone-related conditions, such as impacted common bile duct stones, cholangitis, and biliary pancreatitis, are common medical conditions in daily practice. An early cholecystectomy or drainage procedure with delayed cholecystectomy is the current standard of treatment based on published clinical guidelines. Cirrhosis is not only a condition of chronically impaired hepatic function but also has systemic effects in patients. In cirrhotic individuals, several predisposing factors, including changes in the bile acid compositi...
Source: Gut and Liver - September 16, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Recent Epidemiology of Nonalcoholic Fatty Liver Disease.
Authors: Murag S, Ahmed A, Kim D Abstract The ongoing obesity epidemic and the increasing recognition of metabolic syndrome have contributed to the growing prevalence of nonalcoholic fatty liver disease (NAFLD), the most common form of liver disease worldwide. It is imperative to understand the incidence and prevalence of NAFLD as it is associated with a profound economic burden of hospitalizations, including the shifting trends in liver transplantation. The long-term cumulative healthcare cost of NAFLD patients has been shown to be 80% higher than that of non-NAFLD patients. We explore diagnostic challenges in ide...
Source: Gut and Liver - September 16, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Reversal of the Methylation-Associated Regulation of miR-200a/b by Helicobacter pylori Eradication Contributes to the Chemoprevention of Gastric Carcinogenesis.
Authors: Kim N PMID: 32921637 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - September 16, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

The Clinical Significance and Risk Factors of Colorectal Stricture in Ulcerative Colitis.
Authors: Park SC, Jeen YT PMID: 32921638 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - September 16, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Guidelines for Nonvariceal Upper Gastrointestinal Bleeding.
Authors: Kim JS, Kim BW, Kim DH, Park CH, Lee H, Joo MK, Jung DH, Chung JW, Choi HS, Baik GH, Lee JH, Song KY, Hur S Abstract Nonvariceal upper gastrointestinal bleeding (NVUGIB) refers to bleeding that develops in the gastrointestinal tract proximal to the ligament of Treitz. NVUGIB requires hospitalization and is associated with significant morbidity and mortality. Although European and Asian-Pacific guidelines have been published, there have been no previous guidelines regarding management of NVUGIB in Korea. Korea has a high prevalence of Helicobacter pylori infections, and patients have easy accessibility to e...
Source: Gut and Liver - September 16, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Independent Risk Factors for Hepatocellular Carcinoma Recurrence after Direct-Acting Antiviral Therapy in Patients with Chronic Hepatitis C.
This study was performed to evaluate the efficacy of direct-acting antivirals (DAAs) in Korean patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) and to investigate the risk factors associated with HCC recurrence. Methods: A total of 100 patients with HCV-related HCC, who were treated with DAAs between May 2015 and December 2016, were recruited from seven university hospitals in Korea. Claim data of 526 patients with HCC obtained from the Health Insurance Review and Assessment Service in South Korea were used for external validation of the results. Results: Among the 100 patients, 88% achi...
Source: Gut and Liver - September 8, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Comparison of Long-term Outcomes of Infliximab versus Adalimumab in 1,488 Biologic-Naive Korean Patients with Crohn's Disease.
Conclusions: In this nationwide population-based study, no significant difference was found in the long-term effectiveness of IFX and ADA in the real-world setting of biologic-naive Korean patients with CD. In the absence of trials to directly compare IFX and ADA, our study indicates that the selection of one of these two biologics can be determined by patient and/or physician preference. PMID: 32839359 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - August 27, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Comparison of Clinical Outcomes of Borderline Resectable Pancreatic Cancer According to the Neoadjuvant Chemo-Regimens: Gemcitabine versus FOLFIRINOX.
Authors: Choi YJ, Byun Y, Kang JS, Kim HS, Han Y, Kim H, Kwon W, Oh DY, Paik WH, Lee SH, Ryu JK, Kim YT, Lee K, Kim H, Chie EK, Jang JY Abstract Background/Aims: Although many studies have reported the promising effect of neoadjuvant treatment for borderline resectable pancreatic cancer (BRPC) to increase resectability, only a few studies have recommended the use of firstline chemotherapeutic agents as neoadjuvant treatment for BRPC. The current study compared clinical outcomes between gemcitabine and FOLFIRINOX (5-fluorouracil, leucovorin, oxaliplatin, and irinotecan) in patients with BRPC. Methods: In this si...
Source: Gut and Liver - August 27, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Clinical Significance of Residual Nonrectal Inflammation in Ulcerative Colitis Patients in Clinical Remission.
Conclusions: We suggest that escalation of treatment modalities may be selectively performed in consideration of the residual mucosal inflammation pattern, even if ER has not been achieved, in UC patients with CR. PMID: 32839361 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - August 27, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Change in the Recurrence Pattern and Predictors over Time after Complete Cure of Hepatocellular Carcinoma.
Authors: Lee HA, Lee YS, Kim BK, Jung YK, Kim SU, Park JY, Kim JH, An H, Kim DY, Yim HJ, Ahn SH, Yeon JE, Byun KS, Han KH, Um SH, Seo YS Abstract Background/Aims: We investigated changes in recurrence rates and significant recurrence predictors over time after complete cure of hepatocellular carcinoma (HCC). Methods: A total of 1,491 patients with first-time diagnosis of Barcelona Clinic Liver Cancer stage A HCC, completely cured by treatment between 2007 and 2016, were recruited from two Korean tertiary institutes. Results: The mean age of the population (1,144 men and 347 women) was 58.6 years. Of the tot...
Source: Gut and Liver - August 27, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Factors Related to Outcomes of Fecal Microbiota Transplantation in Patients with Clostridioides difficile Infection.
Conclusions: FMT is highly effective in partially treated CDI but not in refractory CDI. The microbiome differs between failed and successful cases. Frozen stock for FMT is viable up to 48 weeks. PMID: 32839363 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - August 27, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Colonoscopic Polypectomy Preferences of Asian Endoscopists: Results of a Survey-Based Study.
Conclusions: The polypectomy practice patterns of Asian endoscopists vary, and cold snare polypectomy was not the most preferred resection method for polyps
Source: Gut and Liver - August 27, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Real-Life Effectiveness and Safety of Glecaprevir/Pibrentasvir for Korean Patients with Chronic Hepatitis C at a Single Institution.
Conclusions: These real-life data indicated that G/P treatment was highly effective and well tolerated, regardless of viral genotype or patient comorbidities. PMID: 32839365 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - August 27, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Application of Artificial Intelligence in the Detection and Characterization of Colorectal Neoplasm.
Authors: Kim KO, Kim EY Abstract Endoscpists always have tried to pursue a perfect colonoscopy, and application of artificial intelligence (AI) using deep-learning algorithms is one of the promising supportive options for detection and characterization of colorectal polyps during colonoscopy. Many retrospective studies conducted with real-time application of AI using convolutional neural networks have shown improved colorectal polyp detection. Moreover, a recent randomized clinical trial reported additional polyp detection with shorter analysis time. Studies conducted regarding polyp characterization provided addit...
Source: Gut and Liver - August 14, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Contrast Harmonic-Enhanced Endoscopic Ultrasound (EUS) Is the Perfect Companion of EUS-Guided Tumor Ablation.
Authors: Marocchi G, Lisotti A, Fusaroli P PMID: 32773387 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - August 14, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Clinical Outcomes of Endoscopic Resection for Low-Grade Dysplasia and High-Grade Dysplasia on Gastric Pretreatment Biopsy: Korea ESD Study Group.
Conclusions: A substantial proportion of LGDs and HGDs on pretreatment FB were diagnosed as GC after ER. Accurate ER procedures such as endoscopic submucosal dissection should be recommended in cases of LGD and HGD with factors predicting pathologic upstaging to GC. PMID: 32773388 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - August 14, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Helicobacter pylori Eradication Induced Constant Decrease in Interleukin-1B Expression over More Than 5 Years in Patients with Gastric Cancer and Dysplasia.
Conclusions: Infection with Hp has an effect on the level of IL-1B mRNA in IM-negative subjects. The continuous reduction in the IL-1B mRNA level in patients with GC/dysplasia after Hp eradication contributes to the prevention of metachronous GC after Hp eradication. PMID: 32703913 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - July 28, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Endoscopic Ultrasound-Guided Hepaticogastrostomy: Technical Review and Tips to Prevent Adverse Events.
Authors: Ogura T, Higuchi K Abstract Most patients who require biliary drainage can be treated by endoscopic retrograde cholangiopancreatography (ERCP)- guided procedures. However, ERCP can be challenging in patients with complications, such as malignant duodenal obstruction, or a surgically-altered anatomy, such as a Rouxen- Y anastomosis, which prevent advancement of the duodenoscope into the ampulla of Vater. Recently, endoscopic ultrasound (EUS)-guided biliary drainage via transhepatic or transduodenal approaches has emerged as an alternative means of biliary drainage. Typically, EUS-guided gallbladder drainage...
Source: Gut and Liver - July 23, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Anxiety and Depression in Patients with Inflammatory Bowel Diseases: The First Step toward Proper Management.
Authors: Lee JW PMID: 32655016 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - July 15, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Does the Cytogenetic Analysis Using Fluorescence In Situ Hybridization Improve the Preoperative Diagnostic Accuracy of Pancreatic Ductal Adenocarcinoma?
Authors: Kim DU PMID: 32655017 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - July 15, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Corrigendum: Magnetic Resonance Elastography and Diffusion Weighted Imaging in the Evaluation of Hepatic Fibrosis in Chronic Hepatitis B.
Authors: Hennedige TP, Wang G, Leung FP, Alsaif HS, Teo LL, Lim SG, Wee A, Venkatesh SK PMID: 32655018 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - July 15, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Efficacy and Safety of Peroral Endoscopic Myotomy in Achalasia Patients with Failed Previous Intervention: A Systematic Review and Meta-Analysis.
Authors: Tan S, Zhong C, Ren Y, Luo X, Xu J, Fu X, Peng Y, Tang X Abstract Background/Aims: Peroral endoscopic myotomy (POEM) has emerged as a rescue treatment for recurrent or persistent achalasia after failed initial management. Therefore, we aimed to investigate the efficacy and safety of POEM in achalasia patients with failed previous intervention. Methods: We searched the MEDLINE, Embase, Cochrane, and PubMed databases using the queries "achalasia," "peroral endoscopic myotomy," and related terms in March 2019. Data on technical and clinical success, adverse events, Eckardt score and lo...
Source: Gut and Liver - July 5, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Overview of Helicobacter pylori Infection in Indonesia: What Distinguishes It from Countries with High Gastric Cancer Incidence?
Authors: Miftahussurur M, Waskito LA, Fauzia KA, Mahmudah I, Doohan D, Adnyana IK, Khomsan A, Ratnasari N, Rezkitha YAA Abstract Helicobacter pylori infects more than half the human population. However, the prevalence in Indonesia is low, as is the prevalence of gastric cancer. Hence, it could be instructive to compare these prevalence rates and their determining factors with those of countries that have high gastric cancer incidence. Ethnicity and genetic characteristics of H. pylori are important determinants of the H. pylori infection rate in Indonesia. The infection rate is higher in Bataknese, Papuans and Bugi...
Source: Gut and Liver - July 5, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Enteroscopy in Crohn's Disease: Are There Any Changes in Role or Outcomes Over Time? A KASID Multicenter Study.
Conclusions: The overall clinical indications, outcomes, and effectiveness of BAE were constant over time in CD patients with SB involvement, with the exception that the frequency of enteroscopic intervention increased remarkably. PMID: 32616680 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - July 5, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Metabolically Healthy Obesity Is Associated with an Increased Risk of Colorectal Adenoma Occurrence Diagnosed by Surveillance Colonoscopy.
Conclusions: In this study, metabolically healthy obese individuals and metabolically abnormal obese individuals exhibited increased risks of occurrence of colorectal adenoma diagnosed by surveillance colonoscopy. This finding implies that obesity itself, even without metabolic abnormalities, is associated with an increased risk of adenoma recurrence. PMID: 32616681 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - July 5, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Comorbidities and Prescribed Medications in Korean Patients with Chronic Hepatitis C: A Nationwide, Population-Based Study.
Conclusions: The majority of CHC patients had comorbidities; almost all patients took multiple prescribed medications, the number of which increased with age, and significant DDI risk was present in 97% of this Korean patient cohort. Comorbidities and comedication profiles should be considered during DAA therapy. PMID: 32616682 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - July 5, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Comparison of Long-Term Outcomes of Infliximab versus Adalimumab Treatment in Biologic-Na ïve Patients with Ulcerative Colitis.
Conclusions: In our study, infliximab and adalimumab had similar treatment efficacy and long-term outcomes in biologic-naïve patients with moderate to severe UC. PMID: 32616683 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - July 5, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

The Safety of Radiofrequency Ablation Using a Novel Temperature-Controlled Probe for the Treatment of Residual Intraductal Lesions after Endoscopic Papillectomy.
Conclusions: The new temperature-controlled RFA probe can be used with acceptable safety for the treatment of residual intraductal lesions after endoscopic papillectomy. Further evaluation through future prospective studies is needed. PMID: 32616684 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - July 5, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Expression of Receptors for SARS-CoV-2 in the Gut of Patients with Inflammatory Bowel Disease.
Authors: Monteleone G, Franzè E, Laudisi F PMID: 32482915 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - June 4, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Endoscopic Ultrasound-Guided Tissue Acquisition by 22-Gauge Franseen and Standard Needles for Solid Pancreatic Lesions.
Authors: Ishigaki K, Nakai Y, Oyama H, Kanai S, Suzuki T, Nakamura T, Sato T, Hakuta R, Saito K, Saito T, Takahara N, Hamada T, Mizuno S, Kogure H, Tada M, Isayama H, Koike K Abstract Background/Aims: Recently, a three-plane symmetric needle with Franseen geometry was developed for endoscopic ultrasound-guided fine needle biopsy (EUS-FNB). In this retrospective study, tissue acquisition per pass was compared between 22-gauge Franseen FNB and standard fine needle aspiration (FNA) needles in patients with solid pancreatic lesions. Methods: Consecutive patients who underwent EUS-FNA or EUS-FNB for solid pancreatic...
Source: Gut and Liver - May 29, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Prognostic Value of the Alcoholic Hepatitis Histologic Score in Korean Patients with Biopsy-Proven Alcoholic Hepatitis.
This study validated the AHHS in a Korean patient cohort. Methods: We conducted a prospective cohort study of hospitalized Korean patients with AH between January 2010 and August 2017. Histopathological findings were assessed to determine the AHHS in all study subjects. Histopathological risk factors were examined by Cox regression analysis to predict overall survival (OS). Kaplan-Meier curves were plotted to assess the diagnostic performance of the AHHS. Results: We recruited a total of 107 patients with biopsy-proven AH. None of the individual AHHS components were associated with 3-month mortality. However, the b...
Source: Gut and Liver - May 29, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Compositional and Functional Changes in the Gut Microbiota in Irritable Bowel Syndrome Patients.
Conclusions: Changes in the gut microbiota composition in IBS patients lead to alterations in bacterial functions, such as bile acid transformation and the induction of inflammation, which is a known pathophysiological mechanism of IBS. PMID: 32457278 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - May 29, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Entecavir Reduced Serum Hepatitis B Core-Related Antigen in Chronic Hepatitis B Patients with Hepatocellular Carcinoma.
Authors: Mak LY, Ko KL, To WP, Wong DK, Seto WK, Fung J, Yuen MF Abstract Serum hepatitis B core-related antigen (HBcrAg) was shown to predict the risk of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients undergoing treatment. We investigated the longitudinal profile of HBcrAg in entecavir (ETV)-treated CHB patients with subsequent HCC development. We identified HCC cases diagnosed at ≥1 year after ETV initiation. CHB patients without HCC (matched for age, sex, cirrhosis status, baseline hepatitis B virus (HBV) DNA level, and ETV treatment duration) were identified as controls at an HCC:non-HC...
Source: Gut and Liver - May 29, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

To Do or Not to Do: Whether to Hold or Continue Antithrombotics before Endoscopy.
Authors: Kim JS, Kim BW PMID: 32400143 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - May 14, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research