Endoscopic Submucosal Dissection Using Endoscopic Robot: Endoscopist's Future Destination.
Authors: Lee HL PMID: 31284359 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - July 12, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Nonalcoholic Fatty Liver Disease Is a Stepping Stone in the Path toward Diabetes Mellitus.
Authors: Heo NY PMID: 31284360 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - July 12, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Differentiation of Type 2 Autoimmune Pancreatitis Presenting as Clinical Acute Pancreatitis.
Authors: Lee TH PMID: 31284361 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - July 12, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Perspectives on Current and Novel Treatments for Inflammatory Bowel Disease.
Authors: Na SY, Moon W Abstract New therapeutic strategies in inflammatory bowel disease (IBD) have shifted from symptom control towards treat-totarget algorithms in order to optimize treatment results. The treatment of IBD has evolved with the development of tumor necrosis factor-α inhibitors beyond the conventional therapies. In spite of their long-term effectiveness, many patients do not respond to or cannot sustain treatment with these drugs, which have various side effects. Therefore, the development of new drugs targeting specific pathways in the pathogenesis of IBD has become necessary. Some novel biol...
Source: Gut and Liver - June 14, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Extrahepatic Manifestations of Nonalcoholic Fatty Liver Disease.
Authors: Li AA, Ahmed A, Kim D Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and encompasses a spectrum of pathology from simple steatosis to inflammation and significant fibrosis that leads to cirrhosis. NAFLD and its comorbid conditions extend well beyond the liver. It is a multisystemic clinical disease entity with extrahepatic manifestations such as cardiovascular disease, type 2 diabetes, chronic kidney disease, hypothyroidism, polycystic ovarian syndrome, and psoriasis. Indeed, the most common causes of mortality in subjects with NAFLD are cardiovascular disease, f...
Source: Gut and Liver - June 14, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Mesenchymal Stem Cells Decrease Oxidative Stress in the Bowels of Interleukin-10 Knockout Mice.
Conclusions: MSCs affect the redox balance, leading to the suppression of IBD. PMID: 31158947 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - June 6, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Nucleos(t)ide Analogues for Reducing Hepatocellular Carcinoma in Chronic Hepatitis B Patients: A Systematic Review and Meta-Analysis.
Conclusions: ETV or TDF should be used for long-term first-line monotherapy in CHB patients according to the current guidelines. Standardized protocols are needed for future studies of ETV and TDF to facilitate conclusive comparisons. Patients with cirrhosis are at significantly elevated risk for HCC, despite the benefits of NA treatment. PMID: 31158948 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - June 6, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer.
Conclusions: Lower BMI and a multiplicity of index cancers were significantly associated with the surgical resection of MGC. Close follow-up is needed to minimize additional treatment for cases at high risk of advanced MGC after ESD for EGC. PMID: 31158949 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - June 6, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Epidemiological and Clinical Characteristics of Hepatitis C Virus Infection in South Korea from 2007 to 2017: A Prospective Multicenter Cohort Study.
Conclusions: More than 90% of CHC patients were over 40 years old, the major genotypes were 1b and 2, and IVDU was observed in less than 6% of CHC patients. Approximately half of the patients underwent antiviral therapy even in the DAA era, showing an unmet need with regard to HCV elimination. PMID: 31158950 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - June 6, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Changes in Direct Healthcare Costs Before and After the Diagnosis of Inflammatory Bowel Disease: A Nationwide Population-Based Study.
Authors: Lee J, Im JP, Han K, Kim J, Lee HJ, Chun J, Kim JS Abstract Background/Aims: We aimed to investigate the differences in direct healthcare costs between patients with and without inflammatory bowel disease (IBD) and changes in direct healthcare costs before and after IBD diagnosis. Methods: This population-based study identified 34,167 patients with IBD (23,153 patients with Crohn's disease and 11,014 patients with ulcerative colitis) and 102,501 age-and sex-matched subjects without IBD (the control group) from the National Health Insurance database using the International Classification of Disease, 10t...
Source: Gut and Liver - June 6, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Ex Vivo T Cell Cytokine Expression Predicts Survival in Patients with Severe Alcoholic Hepatitis.
Authors: Dhanda AD, Yates E, Schewitz-Bowers LP, Lait PJ, Lee RWJ, Cramp ME Abstract Alcoholic hepatitis (AH) is an acute inflammatory liver condition with high early mortality rate. Steroids have been demonstrated to lead to short-term survival benefits but nonresponders have the worst outcomes. There is a clinical need to identify these high-risk individuals at the time of presentation. T cells have been implicated in AH and steroid responsiveness. We aimed to measure ex vivo T cell cytokine expression as a candidate biomarker of outcomes in patients with AH. Consecutive patients with AH (patients with bilirubin ...
Source: Gut and Liver - June 6, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Stable Gastric Pentadecapeptide BPC 157, Robert's Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selye's Stress Coping Response: Progress, Achievements, and the Future.
Authors: Sikiric P, Hahm KB, Blagaic AB, Tvrdeic A, Pavlov KH, Petrovic A, Kokot A, Gojkovic S, Krezic I, Drmic D, Rucman R, Seiwerth S Abstract We reviewed again the significance of the stable gastric pentadecapeptide BPC 157 as a likely mediator of Robert's stomach cytoprotection/adaptive cytoprotection and organoprotection and as novel mediator of Selye's stress coping response to reestablish homeostasis. Specific points of BPC 157 therapy and the original concept of Robert's cytoprotection/adaptive cytoprotection/organoprotection are discussed, including the beneficial effects of BPC 157. First, BPC 157 protect...
Source: Gut and Liver - June 6, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Robot-Assisted Endoscopic Resection: Current Status and Future Directions.
Authors: Kaan HL, Ho KY Abstract Therapeutic endoscopic resection has gained favor for its ability to achieve high en bloc and histologically complete resection rates via a minimally invasive approach. The main technical difficulties faced by interventionists are first the lack of traction causing suboptimal visualization of the dissection field and second, the lack of triangulation using existing therapeutic apparatuses. These challenges can be overcome with the use of robots and the multiple degrees of freedom afforded by the robotic wrists. Nevertheless, complications such as bleeding and perforation can occur. ...
Source: Gut and Liver - June 6, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Which Needle Needs to Be Chosen for Better Outcome of Endoscopic Ultrasound-Guided Tissue Acquisition?
Authors: Lee DW, Kim EY PMID: 31092725 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - May 18, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Developing Consilience Medicine: Positron Emission Tomography Scan and Transcriptomics in Pancreatic Cancer.
Authors: Kim SH, Lee SO PMID: 31092726 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - May 18, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Long-term Nucleotide Analogue Treatment Has Higher Levels of Renal Toxicities than Does Entecavir in Patients with Chronic Hepatitis B.
Authors: Cho YY, Chang Y, Nam JY, Cho H, Cho EJ, Lee JH, Yu SJ, Yoon JH, Kim YJ Abstract Background/Aims: Renal toxicity is a concern in patients with chronic hepatitis B taking nucleotide analogues, such as adefovir (ADV) and tenofovir disoproxil fumarate (TDF). We sought to determine the long-term renal effects of nucleotide analogue treatment versus entecavir (ETV) treatment. Methods: In this retrospective single-center study, we selected 87 patients who were treated with ADV and subsequently with TDF from June 2008 to December 2013. ETV-treated patients were matched by treatment duration. We analyzed the cr...
Source: Gut and Liver - May 8, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Timing and Clinical Features of Spontaneous Decrease in Size of Small Pancreatic Cystic Lesions without High-Risk Stigmata.
This study aimed to investigate the timing of spontaneous decrease in the size of PCLs without high-risk stigmata and to identify the characteristics associated with their complete resolution. Methods: From 2000 to 2016, patients with spontaneous decreases in PCL size on computed tomography (CT) and/or magnetic resonance imaging (MRI) who had at least 1 year of follow-up were evaluated retrospectively. Results: A total of 78 patients underwent follow-up for an average of 55.7 months. Most patients were asymptomatic, and 35 (37.2%) showed complete resolution. The initial mean PCL size was 1.6±0.9 cm (range, 0...
Source: Gut and Liver - May 8, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Predictive Model of Nonneoplastic Pathology after Endoscopic Resection of Gastric Epithelial Neoplasia.
Authors: Gweon TG, Kim BW, Kim JS, Park SM, Ji JS, Lee BI Abstract Background/Aims: The rate of nonneoplastic pathology (NNP) after endoscopic resection (ER) of gastric epithelial neoplasia (GEN) has been reported to be 3%-7%. However, to date, the associations of pretreatment characteristics with NNP have not been identified. The aim of this study was to develop a predictive model for NNP after ER. Methods: Among 817 patients who underwent ER for GEN, factors associated with NNP were identified by univariate and multivariate analyses. Weighted points considering the β coefficient were allocated to each va...
Source: Gut and Liver - May 8, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Clinical Outcomes of Biliary Drainage during a Neoadjuvant Therapy for Pancreatic Cancer: Metal versus Plastic Stents.
Authors: Kuwatani M, Nakamura T, Hayashi T, Kimura Y, Ono M, Motoya M, Imai K, Yamakita K, Goto T, Takahashi K, Maguchi H, Hirano S Abstract Background/Aims: Neoadjuvant chemotherapy/neoadjuvant chemoradiotherapy (NAC/NACRT) can be performed in patients with pancreatic cancer to improve survival. We aimed to clarify the clinical outcomes of biliary drainage with a metal stent (MS) or a plastic stent (PS) during NAC/NACRT. Methods: Between October 2013 and April 2016, 96 patients with pancreatic cancer were registered for NAC/NACRT. Of these, 29 patients who underwent biliary drainage with MS or PS before NAC/NA...
Source: Gut and Liver - May 8, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Impact of Hospital Volume and the Experience of the Endoscopist on Adverse Events Related to Endoscopic Retrograde Cholangiopancreatography: A Prospective Observational Study.
Conclusions: Our study demonstrated that overall AEs following ERCP were associated with the experience of the endoscopist. To minimize post-ERCP AEs, rigorous training with a sufficient case volume is required, and treatment strategies should be modified according to the endoscopist’s expertise. PMID: 31060119 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - May 8, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

2018 Korean Liver Cancer Association-National Cancer Center Korea Practice Guidelines for the Management of Hepatocellular Carcinoma.
Authors: Korean Liver Cancer Association, National Cancer Center Abstract Hepatocellular carcinoma (HCC) is the fifth most common cancer globally and the fourth most common cancer in men in Korea, where the prevalence of chronic hepatitis B infection is high in middle-aged and elderly patients. These practice guidelines will provide useful and constructive advice for the clinical management of patients with HCC. A total of 44 experts in hepatology, oncology, surgery, radiology and radiation oncology in the Korean Liver Cancer Association-National Cancer Center Korea Practice Guideline Revision Committee revised the...
Source: Gut and Liver - May 8, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

A Proposal for Modification of the Barcelona Clinic Liver Cancer Staging System Considering the Prognostic Implication of Performance Status.
This study aimed to derive a more relevant staging system by modification of the BCLC system considering the prognostic implication of PS. Methods: A total of 7,501 subjects who were registered in the Korean multicenter hepatocellular carcinoma (HCC) registry database from 2008 to 2013 were analyzed. The relative goodness-of-fit between staging systems was compared using the Akaike information criterion (AIC) and integrated area under the curve (IAUC). Three modified BCLC (mBCLC) systems (#1, #2, and #3) were devised by reducing the role of PS. Results: As a result, the BCLC C stage, which includes patients with PS...
Source: Gut and Liver - April 27, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Management of Antibiotic-Resistant Helicobacter pylori Infection: Perspectives from Vietnam.
Authors: Khien VV, Thang DM, Hai TM, Duat NQ, Khanh PH, Ha DT, Binh TT, Dung HDQ, Trang TTH, Yamaoka Y Abstract Antibiotic resistance is the most important factor leading to the failure of eradication regimens. This review focuses on the prevalence of Helicobacter pylori primary and secondary resistance to clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and multidrug in Vietnam. We searched the PubMed, EMBASE, Vietnamese National Knowledge Infrastructure, and Vietnamese Biomedical databases from January 2000 to December 2016. The search terms included the following: H. pylori infection, anti...
Source: Gut and Liver - April 24, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Detecting Early Pancreatic Cancer: Current Problems and Future Prospects.
Authors: Matsubayashi H, Ishiwatari H, Sasaki K, Uesaka K, Ono H Abstract The number of patients with pancreatic cancer (PC) is currently increasing in both Korea and Japan. The 5-year survival rate of patients with PC 13.0%; however, resection with minimal invasion (tumor size: ≤10 mm) increases the 5-year survival rate to 80%. For this reason, early detection is essential, but most patients with early-stage PC are asymptomatic. Early detection of PC has been reported to require screening of high-risk individuals (HRIs), such as those with a family history of PC, inherited cancer syndromes, intraductal papillar...
Source: Gut and Liver - April 24, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

How Does Ultrasound Manage Pancreatic Diseases? Ultrasound Findings and Scanning Maneuvers.
Authors: Okaniwa S Abstract As ultrasound (US) is simple and less invasive than other imaging modalities, this technique is widely used for mass screening. However, visualizing the entire pancreas due to complicated anatomy, obesity and overlying gas can be difficult. US plays a key role in the diagnosis of pancreatic carcinoma (PC), of which tumors smaller than 10 mm (TS1a) and pancreatic carcinoma in situ (PCIS) are expected to have good prognosis. To detect these forms of PC, main pancreatic duct (MPD) dilatation (3 mm or more) and pancreatic cysts (5 mm or larger) are US findings of high-risk individuals (HRIs)...
Source: Gut and Liver - April 24, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Characterization of Intraductal Papillary Neoplasm of the Bile Duct with Respect to the Histopathologic Similarities to Pancreatic Intraductal Papillary Mucinous Neoplasm.
Authors: Nakanuma Y, Kakuda Y, Uesaka K Abstract Intraductal papillary neoplasms of the bile duct (IPNBs) are known to show various pathologic features and biological behaviors. Recently, two categories of IPNBs have been proposed based on their histologic similarities to pancreatic intraductal papillary mucinous neoplasms (IPMNs): type 1 IPNBs, which share many features with IPMNs; and type 2 IPNBs, which are variably different from IPMNs. The four IPNB subtypes were re-evaluated with respect to these two categories. Intestinal IPNBs showing a predominantly villous growth may correspond to type 1, while those show...
Source: Gut and Liver - April 16, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Analysis of Clinical Predictive Factors Affecting the Outcome of 2nd Line Chemotherapy for Gemcitabine-Refractory Advanced Pancreatic Cancer.
Authors: Lee JE, Lee HS, Chung MJ, Park JY, Park SW, Song SY, Bang S Abstract Background/Aims: : The benefit of second-line chemotherapy (SL) after failed first-line chemotherapy(FL) in patients with advanced pancreatic cancer has not yet been established. We evaluated the clinicalcharacteristics affecting the benefits of SL therapy compared to basic supportive care (BSC), identifiedthe prognostic factors, and ultimately devised a model of clinical parameters to assist in making decisionbetween SL and BSC after the failure of gemcitabine-based FL. Methods: : The records of patients whoreceived gemcitabine-based...
Source: Gut and Liver - April 14, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Effect of Helicobacter pylori Treatment on Long-Term Mortality in Patients with Hypertension.
Authors: Kim YI, Kim YA, Lee JW, Kim HJ, Kim SH, Kim SG, Kim JI, Kim JJ, Choi IJ Abstract Background/Aims: : A meta-analysis of randomized trials performed in healthy asymptomaticindividuals suggested that overall mortality may increase after Helicobacter pylori eradication despitea significant decrease in the gastric cancer incidence and mortality rates. This retrospective populationbasedcohort study investigated if H. pylori treatment is associated with an increase in overall mortalityin patients with hypertension. Methods: : From the database of the Korean National Health InsuranceSample Cohort, we selected ...
Source: Gut and Liver - April 14, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

The Impact of National Surveillance for Liver Cancer: Results from Real-World Setting in Korea.
Conclusions: : This study highlights themortality benefit in patients who participated in the NLCSP and the need for continuous improvementsof the NLCSP in South Korea. PMID: 30974929 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 14, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

The role of acid suppressants in the prevention of anticoagulant-related gastrointestinal bleeding: a systematic review and meta-analysis.
Conclusions: : Theprotective effect of PPIs against dicumarinics-related upper GIB was clear, while there was no evidencesupporting the protective effect of acid suppressants against dabigatran-related GIB. However, in theabsence of randomized trials demonstrating a lack of bias, solid conclusions cannot be drawn. PMID: 30974930 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 14, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Safety Evaluation of the Paclitaxel-Eluting Biliary Metal Stent with Sodium Caprate in Porcine Biliary Tract.
Conclusions: : In a prototypic porcine trial, this newly devised metalbiliary stent incorporating both paclitaxel and sodium caprate appears safe in the porcine bileduct. PMID: 30970427 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Effects of preoperative malnutrition on Postoperative Surgical Outcomes and Quality of Life in Elderly Patients with Periampullary Neoplasms: A Single-Center Prospective Cohort Study.
Authors: Kim E, Lee DH, Jang JY Abstract Background/Aims: : We investigated the effect of preoperative malnutrition onpostoperative surgical outcomes in elderly patients undergoing pancreatoduodenectomyfor periampullary neoplasms. Methods: : This prospective cohort study enrolled 154patients aged ≥65 years with periampullary neoplasms. Using the Mini NutritionalAssessment tool, patients were categorized into three groups according to theirpreoperative nutritional status: well nourished (13.0%), at-risk of malnutrition (59.7%),and malnourished (27.3%). Results: : Significant intergroup differences were ob...
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Type 2 Autoimmune Pancreatitis (Idiopathic Duct-Centric Pancreatitis) Highlighting Patients Presenting as Clinical Acute Pancreatitis: A Single-Center Experience.
Conclusions: In South Korea, type 2 AIP is not as rare as previously thought. Overall, the clinical profile of type 2 AIP was similar to that of Western countries. Type 2 AIP should be considered in young UC patients with acute pancreatitis of uncertain etiology. PMID: 30970429 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Novel Prognostic Nomograms for Hepatocellular Carcinoma Patients with Microvascular Invasion: Experience from a Single Center.
Authors: Xu L, Li L, Wang P, Zhang M, Zhang Y, Hao X, Yan L, Li B, Wen T, Xu M Abstract Background/Aims: : The presence of microvascular invasion (MVI) has been widelyrecognized as a negative prognostic factor for patients with hepatocellular carcinoma(HCC) after curative hepatectomy. However, prediction models that specifically focuson the individual prognoses of HCC patients with MVI is lacking. Methods: : The chartsof patients who consecutively underwent hepatectomy and were diagnosed with HCCwith MVI between 2009 and 2015 at the West China Hospital of Sichuan Universitywere reviewed. All eligible patients w...
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Improvement of Nonalcoholic Fatty Liver Disease Reduces the Risk of Type 2 Diabetes Mellitus.
In this study, we tried to analyze the DM risk according to change in NAFLD status over time. Methods: Among a total of 10,141 individuals for whom routine healthcare assessment was performed, 2,726 subjects were selected according to the inclusion/exclusion criteria. NAFLD status change was determined by using serial abdominal ultrasonography and fatty liver index (FLI) during the follow-up period. Results: Subjects were categorized according to change in NAFLD status as follows: 670 subjects in the persistent NAFLD group, 155 subjects in the resolved NAFLD group, 498 subjects in the incident NAFLD group, and 1403...
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

ABC Classification Is Less Useful for Older Koreans Born before 1960.
This study aimed to determine the prevalence andcharacteristics of pseudo group A subjects. Methods: : Group A subjects were identifiedamong consecutive Korean adults who underwent a serum anti-Helicobacter pyloriimmunoglobulin G (IgG) test and pepsinogen (PG) assay on the day of endoscopy. Pastinfection was defined as the presence of either eradication history or endoscopic findingssuggesting past infection (i.e., gastric xanthoma, metaplastic gastritis, or advanced atrophy>closed-type 1). Results: : Among 2,620 group A subjects, 448 (17.1%) had eradicationhistory, and 133 (5.1%) showed endoscopic findings sugg...
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Comparison of the Clinical Characteristics and Outcomes between Leprosy-Affected Persons in Sorokdo and the General Population Affected by Chronic Hepatitis C in Korea.
Conclusions: : Treatment efficacy was not different between the leprosy-affected population and the general population. However, ribavirin-induced severe hemolytic anemia requiring transfusion was present in 28.5% of genotype 2 patients. Therefore, we suggest ribavirin-free DAAs for the treatment of genotype 2 hepatitis C in leprosy-affected persons in the future. PMID: 30970433 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Noninvasive Serum Fibrosis Markers are Associated with Coronary Artery Calcification in Patients with Nonalcoholic Fatty Liver Disease.
Conclusions: : The NFS and FIB-4 score were associated with coronaryatherosclerosis in subjects with NAFLD. Furthermore, scores integrating these noninvasivescores and risk factors for CVD showed good discriminatory power in predicting CACS>100.Therefore, noninvasive serum fibrosis markers may be useful tools for identifying NAFLDsubjects at a high risk for. PMID: 30970434 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Serum Infliximab Cutoff Trough Level Values for Maintaining Hematological Remission in Pediatric Inflammatory Bowel Disease.
Conclusions: : Cutoff values are considereda prerequisite for further investigating the clinical usefulness of measurements of IFX inpatients maintained with IFX treatment. PMID: 30970435 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Using Etomidate/Midazolam for Screening Colonoscopies Results in More Stable Hemodynamic Responses in Patients of All Ages.
Conclusions: : Compared with usingpropofol/midazolam, using etomidate/midazolam for screening colonoscopies results in more stablehemodynamic responses in patients of all ages; therefore, we recommend using etomidate/midazolamfor colonoscopies in patients with cardiovascluar risk factors. PMID: 30970436 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Refeeding Syndrome as a Possible Cause of Very Early Mortality in Acute Pancreatitis.
Conclusions: : The findings of current study emphasize that clinicians should be awareof the possibility of RFS in malnourished AP patients with electrolyte imbalances. PMID: 30970437 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Helicobacter pylori Infection in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis.
Conclusions: The results of this study suggest a lower prevalence of H. pylori infection in patients with CKD. PMID: 30970438 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Long Noncoding RNA N-BLR Upregulates the Migration and Invasion of Gastric Adenocarcinoma.
Authors: Youn YH, Byun HJ, Yoon JH, Park CH, Lee SK Abstract Background/Aims: Gastric cancer is one of the most common malignant tumors worldwide with poor prognosis due to a lack of effective treatment modalities. Recent research showed that a long noncoding RNA named N-BLR modulates the epithelial-to-mesenchymal transition (EMT) process in colorectal cancer. However, the biological role of N-BLR in gastric cancer still remains to be explored. The aim of this study is to investigate the possibility of N-BLR as an EMT modulator in gastric cancer. Methods: The expression of N-BLR was measured by q-PCR in fresh g...
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Effect of Citric Acid on Accuracy of 13C-Urea Breath Test after Helicobacter pylori Eradication Therapy in a Region with a High Prevalence of Atrophic Gastritis.
Authors: Kwon YH, Kim N, Yoon H, Shin CM, Park YS, Lee DH Abstract Background/Aims: The validity of the 13C-urea breath test (13C-UBT) for Helicobacter pylori detection is influenced by the prevalence of atrophic gastritis in the population. Citric acid has been suggested to reduce false positivity in regions where atrophic gastritis is common. The aim of this study was to evaluate the effect of citric acid on the accuracy of the 13C-urea breath test after H. pylori eradication therapy. Methods: In this prospective study, H. pylori-positive patients submitted to 13C-UBT after an H. pylori eradication regimen. P...
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

A Newly Designed 3D Printer-Based Gastric Hemostasis Simulator with Two Modules for Endoscopic Trainees (with Video).
Conclusions: A new 3D-printed hemostasis simulator is capable of hemostasis training and can very effectively train beginners before they perform the procedure in patients with gastrointestinal bleeding. PMID: 30970441 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

The Clinical Efficacy of a Pure Alginate Formulation (Lamina G) for Controlling Symptoms in Individuals with Reflux Symptoms: A Randomized Clinical Study.
Conclusions: The addition of non-bicarbonate alginate to PPI was no more effective than PPI alone in controlling reflux symptoms. PMID: 30970442 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Long-term Clinical Outcomes and Risk of Peritoneal Seeding after Endoscopic Submucosal Dissection for Early Gastric Cancer: A Focus on Perforation during the Procedure.
Conclusions: Perforation associated with ESD does not lead to worse clinical outcomes such as peritoneal seeding or cumulative survival rate. Therefore, periodic follow-up might be possible if curative resection was achieved even if perforation occurred during ESD. PMID: 30970443 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

High efficacy and safety of flat-dose ribavirin plus sofosbuvir/daclatasvir in genotype 3 cirrhotic patients.
Authors: Pellicelli A, Messina V, Giannelli V, Distefano M, Palitti VP, Vignally P, Tarquini P, Izzi A, Moretti A, Babudieri S, Dell'Isola S, Marignani M, Scifo G, Iovinella V, Cariti G, Pompili M, Candilo FD, Fontanella L, Ettorre GM, Vennarecci G, Ippolito AM, Barbarini G Abstract Background/Aims: Patients with genotype 3 hepatitis C virus (G3-HCV) cirrhosis are very difficult to treat compared to patients with other HCV genotypes. The optimal treatment duration and drug regimen associated with ribavirin (RBV) remain unclear. To evaluate the efficacy and safety of daclatasvir (DCV)/sofosbuvir (SOF) plus a flat do...
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Evaluation of Treatment Response after Endoscopic Variceal Obturation with Abdominal Computed Tomography.
Conclusions: Abdominal CT is useful in the evaluation of the treatment response after EVO for GV bleeding. Incomplete cyanoacrylate impaction in feeding vessels is a risk factor for GV rebleeding. PMID: 30970445 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Long-Term Outcome of Endoscopic Retrograde Biliary Drainage (ERBD) of Biliary Stricture Following Living Donor Liver Transplantation.
Conclusions: Long-term outcome (stricture resolution) of the ERBD of biliary stricture occurring after LDLT was 73.4%. Clinicians should be pay careful attention to ERBD removal and follow-up in cases with factors associated with recurrent biliary stricture. PMID: 30970446 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - April 13, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research