Trends in Mortality Related to Hepatitis B and C from 1990 to 2019 in the Western Pacific Region
CONCLUSIONS: : Although the mortality rate from hepatitis B and C decreased from 1990 to 2019, notable variation was observed among 27 Western Pacific countries. Efforts targeting hepatitis B and C prevention and treatment are still required in this region, especially for the pandemic countries.PMID:38638100 | DOI:10.5009/gnl230023 (Source: Gut and Liver)
Source: Gut and Liver - April 19, 2024 Category: Gastroenterology Authors: Hua Zhou Mengxia Yan Datian Che Bin Wu Source Type: research
The Circular RNA Circ_0043947 Promoted Gastric Cancer Progression by Sponging miR-384 to Regulate CREB1 Expression
CONCLUSIONS: : Circ_0043947 acted as an oncogenic factor in GC to mediate GC cell proliferation, migration, and invasion, the cell cycle and apoptosis by regulating the miR-384/CREB1 axis. Circ_0043947 may be a potential target for GC diagnosis and therapy.PMID:38638101 | DOI:10.5009/gnl230173 (Source: Gut and Liver)
Source: Gut and Liver - April 19, 2024 Category: Gastroenterology Authors: Chongxin Zhang Fan Zhang Yukun Li Pengfei Yang Yang Liu Wenxiao Yang Source Type: research
Trends in Mortality Related to Hepatitis B and C from 1990 to 2019 in the Western Pacific Region
CONCLUSIONS: : Although the mortality rate from hepatitis B and C decreased from 1990 to 2019, notable variation was observed among 27 Western Pacific countries. Efforts targeting hepatitis B and C prevention and treatment are still required in this region, especially for the pandemic countries.PMID:38638100 | DOI:10.5009/gnl230023 (Source: Gut and Liver)
Source: Gut and Liver - April 19, 2024 Category: Gastroenterology Authors: Hua Zhou Mengxia Yan Datian Che Bin Wu Source Type: research
The Circular RNA Circ_0043947 Promoted Gastric Cancer Progression by Sponging miR-384 to Regulate CREB1 Expression
CONCLUSIONS: : Circ_0043947 acted as an oncogenic factor in GC to mediate GC cell proliferation, migration, and invasion, the cell cycle and apoptosis by regulating the miR-384/CREB1 axis. Circ_0043947 may be a potential target for GC diagnosis and therapy.PMID:38638101 | DOI:10.5009/gnl230173 (Source: Gut and Liver)
Source: Gut and Liver - April 19, 2024 Category: Gastroenterology Authors: Chongxin Zhang Fan Zhang Yukun Li Pengfei Yang Yang Liu Wenxiao Yang Source Type: research
Unraveling the Heterogeneity of CD8+ T-Cell Subsets in Liver Cirrhosis: Implications for Disease Progression
CONCLUSIONS: : In summary, this comprehensive study defines specialized CD8+ T-cell subpopulations in cirrhosis, with CXCL13+ Tex cells displaying an exhausted phenotype associated with immune dysregulation and advanced disease. Key genes and pathways regulating these cells present potential therapeutic targets.PMID:38623058 | DOI:10.5009/gnl230345 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Kepu Zheng Leiyang Dai Shengning Zhang Yingpeng Zhao Wang Li Yang Gao Yuanyi Mang Lingfeng Jiao Yu Tang Jianghua Ran Source Type: research
A New Risk Prediction Model for Detecting Endoscopic Activity of Ulcerative Colitis
CONCLUSIONS: : The nomogram, which incorporated activated partial thromboplastin time, fecal occult blood test, β2-globulin level, and fibrinogen degradation products, served as a prospective tool for evaluating UC activity in clinical practices.PMID:38623059 | DOI:10.5009/gnl230370 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Guoyu Guan Sangdan Zhuoga Songbai Zheng Kangqiao Xu Tingwen Weng Wensi Qian Danian Ji Xiaofeng Yu Source Type: research
Long-term Outcome of Asymptomatic Esophageal Eosinophilia
CONCLUSIONS: : Some patients with aEE had improved findings without treatment, whereas others developed symptoms, emphasizing the importance of long-term monitoring and individualized treatment decisions.PMID:38623060 | DOI:10.5009/gnl230398 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yugo Suzuki Yorinari Ochiai Daisuke Kikuchi Mako Koseki Kenichi Ohashi Shu Hoteya Source Type: research
Precirrhotic Primary Biliary Cholangitis with Portal Hypertension: Bile Duct Injury Correlate
CONCLUSIONS: : Approximately 24.2% of precirrhotic PBC patients have PH, which is histologically related to the injury of bile ducts. High alkaline phosphatase levels, low white blood cell counts, high Mayo scores, and high FIB-4 index values are associated with increased risk of precirrhotic PBC with PH.PMID:38623061 | DOI:10.5009/gnl230468 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yi-Fan Hu Shun-Xin Li Hong-Li Liu Zhi-Xiang Du Shuang-Shuang Wang Miao-Yang Chen Li Wang Qing-Fang Xiong Yan-Dan Zhong Du-Xian Liu Yong-Feng Yang Source Type: research
Unraveling the Heterogeneity of CD8+ T-Cell Subsets in Liver Cirrhosis: Implications for Disease Progression
CONCLUSIONS: : In summary, this comprehensive study defines specialized CD8+ T-cell subpopulations in cirrhosis, with CXCL13+ Tex cells displaying an exhausted phenotype associated with immune dysregulation and advanced disease. Key genes and pathways regulating these cells present potential therapeutic targets.PMID:38623058 | DOI:10.5009/gnl230345 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Kepu Zheng Leiyang Dai Shengning Zhang Yingpeng Zhao Wang Li Yang Gao Yuanyi Mang Lingfeng Jiao Yu Tang Jianghua Ran Source Type: research
A New Risk Prediction Model for Detecting Endoscopic Activity of Ulcerative Colitis
CONCLUSIONS: : The nomogram, which incorporated activated partial thromboplastin time, fecal occult blood test, β2-globulin level, and fibrinogen degradation products, served as a prospective tool for evaluating UC activity in clinical practices.PMID:38623059 | DOI:10.5009/gnl230370 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Guoyu Guan Sangdan Zhuoga Songbai Zheng Kangqiao Xu Tingwen Weng Wensi Qian Danian Ji Xiaofeng Yu Source Type: research
Long-term Outcome of Asymptomatic Esophageal Eosinophilia
CONCLUSIONS: : Some patients with aEE had improved findings without treatment, whereas others developed symptoms, emphasizing the importance of long-term monitoring and individualized treatment decisions.PMID:38623060 | DOI:10.5009/gnl230398 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yugo Suzuki Yorinari Ochiai Daisuke Kikuchi Mako Koseki Kenichi Ohashi Shu Hoteya Source Type: research
Precirrhotic Primary Biliary Cholangitis with Portal Hypertension: Bile Duct Injury Correlate
CONCLUSIONS: : Approximately 24.2% of precirrhotic PBC patients have PH, which is histologically related to the injury of bile ducts. High alkaline phosphatase levels, low white blood cell counts, high Mayo scores, and high FIB-4 index values are associated with increased risk of precirrhotic PBC with PH.PMID:38623061 | DOI:10.5009/gnl230468 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yi-Fan Hu Shun-Xin Li Hong-Li Liu Zhi-Xiang Du Shuang-Shuang Wang Miao-Yang Chen Li Wang Qing-Fang Xiong Yan-Dan Zhong Du-Xian Liu Yong-Feng Yang Source Type: research
Unraveling the Heterogeneity of CD8+ T-Cell Subsets in Liver Cirrhosis: Implications for Disease Progression
CONCLUSIONS: : In summary, this comprehensive study defines specialized CD8+ T-cell subpopulations in cirrhosis, with CXCL13+ Tex cells displaying an exhausted phenotype associated with immune dysregulation and advanced disease. Key genes and pathways regulating these cells present potential therapeutic targets.PMID:38623058 | DOI:10.5009/gnl230345 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Kepu Zheng Leiyang Dai Shengning Zhang Yingpeng Zhao Wang Li Yang Gao Yuanyi Mang Lingfeng Jiao Yu Tang Jianghua Ran Source Type: research
A New Risk Prediction Model for Detecting Endoscopic Activity of Ulcerative Colitis
CONCLUSIONS: : The nomogram, which incorporated activated partial thromboplastin time, fecal occult blood test, β2-globulin level, and fibrinogen degradation products, served as a prospective tool for evaluating UC activity in clinical practices.PMID:38623059 | DOI:10.5009/gnl230370 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Guoyu Guan Sangdan Zhuoga Songbai Zheng Kangqiao Xu Tingwen Weng Wensi Qian Danian Ji Xiaofeng Yu Source Type: research
Long-term Outcome of Asymptomatic Esophageal Eosinophilia
CONCLUSIONS: : Some patients with aEE had improved findings without treatment, whereas others developed symptoms, emphasizing the importance of long-term monitoring and individualized treatment decisions.PMID:38623060 | DOI:10.5009/gnl230398 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yugo Suzuki Yorinari Ochiai Daisuke Kikuchi Mako Koseki Kenichi Ohashi Shu Hoteya Source Type: research
