The prion protein in neuroimmune crosstalk
Publication date: Available online 15 November 2018Source: Neurochemistry InternationalAuthor(s): Øyvind Salvesen, Jörg Tatzelt, Michael A. TranulisAbstractThe cellular prion protein (PrPC) is a medium-sized glycoprotein, attached to the cell surface by a glycosylphosphatidylinositol anchor. PrPC is encoded by a single-copy gene, PRNP, which is abundantly expressed in the central nervous system and at lower levels in non-neuronal cells, including those of the immune system. Evidence from experimental knockout of PRNP in rodents, goats, and cattle and the occurrence of a nonsense mutation in goat that prevents s...
Source: Neurochemistry International - November 16, 2018 Category: Neuroscience Source Type: research

Enhanced AMPA receptor-mediated excitatory transmission in the rodent rostromedial tegmental nucleus following lesion of the nigrostriatal pathway
Publication date: Available online 15 November 2018Source: Neurochemistry InternationalAuthor(s): Yongli Chang, Chengxue Du, Lingna Han, Shuxuan Lv, Jin Zhang, Guanyun Bian, Guoyi Tang, Yiwei Liu, Tao Chen, Jian LiuAbstractThe GABAergic rostromedial tegmental nucleus (RMTg) has reciprocal connections with the dopaminergic ventral tegmental area and substantia nigra pars compacta (SNc), and is involved in inhibitory control of monoaminergic nuclei. At present, it is not clear whether unilateral 6-hydroxydopamine lesions of the SNc in rats affect AMPA receptor-mediated excitatory transmission in the RMTg. Here we found that ...
Source: Neurochemistry International - November 16, 2018 Category: Neuroscience Source Type: research

Impact of C57BL/6 substrain on sex-dependent differences in mouse stroke models
Publication date: Available online 15 November 2018Source: Neurochemistry InternationalAuthor(s): Thaddeus S. Nowak, Megan K. MulliganAbstractWe have recently found significant variation in stroke vulnerability among substrains of C57BL/6 mice, observing that commonly used N-lineage substrains exhibit larger infarcts than C57BL/6J and related substrains. Parallel variation was also seen with respect to sex differences in stroke vulnerability, in that C57BL/6 mice of the N-lineage exhibited comparable infarct sizes in males and females, whereas infarcts tended to be smaller in females than in males of J-lineage substrains. ...
Source: Neurochemistry International - November 16, 2018 Category: Neuroscience Source Type: research

Autophagy activation alleviates nonylphenol-induced apoptosis in cultured cortical neurons
In conclusion, our findings demonstrate that NP exposure induced apoptosis with a concomitant increase of autophagic flux in primary cortical neurons, which supports the idea that this potential neurotoxin has direct effects of on neurons. Both ER stress and mitochondrial pathways may be involved in NP-induced apoptosis in neurons. Furthermore, our results also suggest that autophagy activation might be a protective strategy to ameliorate NP-induced apoptosis in neurons. (Source: Neurochemistry International)
Source: Neurochemistry International - November 15, 2018 Category: Neuroscience Source Type: research

An overview of the neuroprotective potential of rosmarinic acid and its association with nanotechnology-based delivery systems: A novel approach to treating neurodegenerative disorders
Publication date: Available online 12 November 2018Source: Neurochemistry InternationalAuthor(s): Flávia Nathiely Silveira Fachel, Roselena Silvestri Schuh, Kleyton Santos Veras, Valquíria Linck Bassani, Letícia Scherer Koester, Amelia Teresinha Henriques, Elizandra Braganhol, Helder Ferreira TeixeiraAbstractNeurodegenerative disorders (ND) are characterized by slow and progressive neuronal dysfunction induced by the degeneration of neuronal cells in the central nervous system (CNS). Recently, the neuroprotective effects of natural compounds with anti-inflammatory and antioxidant activities has been cl...
Source: Neurochemistry International - November 12, 2018 Category: Neuroscience Source Type: research

Behavioral tests predicting striatal dopamine level in a rat hemi-Parkinson's disease model
In this study, we performed various behavioral tests (apomorphine-induced rotation, cylinder, forepaw adjustment steps (FAS), beam walking, rota-rod, and open-field), using 6-hydroxydopamine (OHDA) and lipopolysaccharide (LPS)-induced hemi-PD model rats with various striatal DA levels, to find the best way to predict the DA level from earlier disease stages. Different from the 6-OHDA-induced model, reduction in the striatal DA levels in the LPS-model was less significant. Among the behavioral tests, data from cylinder and FAS tests, which evaluate forelimb movements, best correlated with decline of the DA level. They also ...
Source: Neurochemistry International - November 11, 2018 Category: Neuroscience Source Type: research

Pentobarbital and other anesthetic agents induce opposite regulations of MAP kinases p-MEK and p-ERK, and upregulate p-FADD/FADD neuroplastic index in brain during hypnotic states in mice
Publication date: Available online 10 November 2018Source: Neurochemistry InternationalAuthor(s): Glòria Salort, María Álvaro-Bartolomé, Jesús A. García-SevillaAbstractMidazolam and ketamine-induced anesthesia were recently shown to induce a disruption of MEK/ERK sequential phosphorylation with parallel upregulation of p-FADD in the mouse brain. The present study was designed to assess whether other structurally diverse anesthetic agents (pentobarbital, ethanol, chloral hydrate, isoflurane) also impair brain p-MEK to p-ERK signal and increase p-FADD during the particular time cours...
Source: Neurochemistry International - November 11, 2018 Category: Neuroscience Source Type: research

Long-term challenge of methylphenidate changes the neuronal population and membrane property of dopaminergic neuron in rats
This study investigated the impact of long-term treatment of methylphenidate on different neurons. Rats aged 1 month were divided into three groups: Normal group receiving only sucrose solution, Low-dose group receiving 2 mg/kg methylphenidate, and High-dose group receiving 10 mg/kg methylphenidate; for each group, the drug was administreted twice per day. After 7 months of the treatment period, then the alterations in number of norepinephrine, serotonergic, cholinergic and dopaminergic neurons were quantified. The number of dopaminergic neurons in the substantia nigra (SN), the serotonergic neurons in the dorsal raphe...
Source: Neurochemistry International - November 11, 2018 Category: Neuroscience Source Type: research

Microglia metabolism in health and disease
Publication date: Available online 10 November 2018Source: Neurochemistry InternationalAuthor(s): Katharina Borst, Marius Schwabenland, Marco PrinzAbstractIn the last decade tremendous progress has been made in understanding how the immune system reacts to insults. During this progress it became obvious that those immune responses are tightly regulated and cross-linked with distinct metabolic changes in immune cells. Extensive research has been conducted mainly on subtypes of T cells, which use different metabolic pathways during differentiation processes and activation states. In addition, it has also been established lat...
Source: Neurochemistry International - November 11, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: December 2018Source: Neurochemistry International, Volume 121Author(s): (Source: Neurochemistry International)
Source: Neurochemistry International - November 6, 2018 Category: Neuroscience Source Type: research

Sex differences in miRNA as therapies for ischemic stroke
Publication date: Available online 2 November 2018Source: Neurochemistry InternationalAuthor(s): Farida Sohrabji, Amutha SelvamaniAbstractMicroRNAs, a subset of non-coding RNAs, are present in virtually all tissues including body fluids and are global regulators of the transcriptome. In view of the expanding number of microRNAs and the large number of gene targets that each microRNA can potentially regulate, they have been compared to hormones in the scope of their effects. MicroRNA have been implicated as biomarkers for several diseases including stroke, as well as chronic conditions that are associated with stroke. Recen...
Source: Neurochemistry International - November 3, 2018 Category: Neuroscience Source Type: research

Protein disulfide-isomerase A3 significantly reduces ischemia-induced damage by reducing oxidative and endoplasmic reticulum stress
Publication date: Available online 3 November 2018Source: Neurochemistry InternationalAuthor(s): Dae Young Yoo, Su Bin Cho, Hyo Young Jung, Woosuk Kim, Kwon Young Lee, Jong Whi Kim, Seung Myung Moon, Moo-Ho Won, Jung Hoon Choi, Yeo Sung Yoon, Dae Won Kim, Soo Young Choi, In Koo HwangAbstractIschemia causes oxidative stress in the endoplasmic reticulum (ER), accelerates the accumulation of unfolded and misfolded proteins, and may ultimately lead to neuronal cell apoptosis. In the present study, we investigated the effects of protein disulfide-isomerase A3 (PDIA3), an ER-resident chaperone that catalyzes disulfide-bond forma...
Source: Neurochemistry International - November 3, 2018 Category: Neuroscience Source Type: research

The GSK3β inhibitor, TDZD-8, rescues cognition in a zebrafish model of okadaic acid-induced Alzheimer's disease
This study was designed to investigate the effects of GSK3β inhibition by 4-benzyl-2-methyl-1, 2, 4-thiadiazolidine-3, 5-dione (TDZD-8) on this newly developed AD model. Fish were divided into 4 groups and each group received a different treatment. The fish were divided into a control group, a group treated with 1 μM TDZD-8 only, a group treated with 1 μM TDZD-8 + 100 nM OKA, and a group treated with 100 nM OKA only. Administering the GSK3β inhibitor to zebrafish concomitantly with OKA proved to be protective. TDZD-8 treatment reduced the mortality rate, the ratio of active: inactive GSK...
Source: Neurochemistry International - October 29, 2018 Category: Neuroscience Source Type: research

Clinical spectrum of inflammatory central nervous system demyelinating disorders associated with antibodies against myelin oligodendrocyte glycoprotein
Publication date: Available online 23 October 2018Source: Neurochemistry InternationalAuthor(s): Tetsuya Akaishi, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Ichiro NakashimaAbstractImmunoglobulin G (IgG) antibodies against myelin oligodendrocyte glycoprotein (MOG) are detected in the serum of some patients with demyelinating diseases. These patients are known to show repeated clinical episodes of inflammatory demyelinating attacks in the central nervous system. Although the associated pathogenicity and mechanism of inflammatory demyelination remains inconclusive, it is known that patients with MOG-IgG antibodies have a d...
Source: Neurochemistry International - October 24, 2018 Category: Neuroscience Source Type: research

MiR-34a and stroke: Assessment of non-modifiable biological risk factors in cerebral ischemia
Publication date: Available online 23 October 2018Source: Neurochemistry InternationalAuthor(s): Xuefang Ren, Elizabeth B. Engler-Chiurazzi, Ashley E. Russell, Saumyendra N. Sarkar, Stephanie L. Rellick, Sara Lewis, Deborah Corbin, Jared Clapper, James W. SimpkinsAbstractAging of the nervous system, and the occurrence of age-related brain diseases such as stroke, are associated with changes to a variety of cellular processes controlled by many distinct genes. MicroRNAs (miRNAs), short non-coding functional RNAs that can induce translational repression or site-specific cleavage of numerous target mRNAs, have recently emerge...
Source: Neurochemistry International - October 24, 2018 Category: Neuroscience Source Type: research

Methoxetamine: A foe or friend?
Publication date: Available online 24 October 2018Source: Neurochemistry InternationalAuthor(s): Chrislean Jun Botanas, June Bryan de la Peña, Hee Jin Kim, Yong Sup Lee, Jae Hoon CheongAbstractMethoxetamine (MXE) is an N-methyl-D-aspartate (NMDA) receptor antagonist that is chemically and pharmacologically similar to other dissociative substances, such as ketamine and phencyclidine. There are reports on the misuse of MXE, which sometimes resulted in adverse consequences and death. Studies have also shown that MXE has abuse liability and stimulates dopamine neurotransmission in the mesolimbic reward pathway in the br...
Source: Neurochemistry International - October 24, 2018 Category: Neuroscience Source Type: research

Knockdown of RTN1-C attenuates traumatic neuronal injury through regulating intracellular Ca2+ homeostasis
Publication date: Available online 21 October 2018Source: Neurochemistry InternationalAuthor(s): Xiao-xuan Fan, Yu-ying Hao, Shi-wen Guo, Xiao-ping Zhao, Yi Xiang, Fei-xue Feng, Ge-ting Liang, Yu-wei DongAbstractReticulons (RTNs) are a family of membrane-bound proteins that are dominantly localized to the endoplasmic reticulum (ER) membrane. RTN1-C is one member of RTNs abundantly expressed in the brain and has been shown to mediate neuronal injury in cerebral ischemia models. In the present study, we investigated the role of RTN1-C in an in vitro brain trauma model mimicked by traumatic neuronal injury (TNI) in primary cu...
Source: Neurochemistry International - October 21, 2018 Category: Neuroscience Source Type: research

Docosahexaenoic acid protection in a rotenone induced Parkinson's model: Prevention of tubulin and synaptophysin loss, but no association with mitochondrial function
Publication date: Available online 19 October 2018Source: Neurochemistry InternationalAuthor(s): Norma Serrano-García, Francisca Fernández-Valverde, Erika Rubi Luis-Garcia, Leticia Granados-Rojas, Tarsila Elizabeth Juárez-Zepeda, Sandra Adela Orozco-Suárez, José Pedraza-Chaverri, Marisol Orozco-Ibarra, Anabel Jiménez-AnguianoAbstractRotenone, a classic mitochondrial complex I inhibitor, leads to dopaminergic neuronal death resulting in a Parkinson's-like-disease. Docosahexaenoic acid (DHA) has shown neuroprotective effects in other experimental models of Parkinson's disease, but it...
Source: Neurochemistry International - October 20, 2018 Category: Neuroscience Source Type: research

Adrenergic control of lymphocyte trafficking and adaptive immune responses
Publication date: Available online 19 October 2018Source: Neurochemistry InternationalAuthor(s): Akiko Nakai, Kazuhiro SuzukiAbstractSince the beginning of the last century, substantial evidence has suggested that various aspects of the immune system are influenced by the activity of the nervous system. However, the cellular and molecular basis for the neural control of immune responses has emerged only in the past decade. Recent studies have shown that adrenergic nerves control trafficking of immune cells through cell-type-specific mechanisms. Activation of the β2-adrenergic receptor expressed on lymphocytes enhances...
Source: Neurochemistry International - October 20, 2018 Category: Neuroscience Source Type: research

Inflammation and neural repair after ischemic brain injury
Publication date: Available online 19 October 2018Source: Neurochemistry InternationalAuthor(s): Seiichiro Sakai, Takashi ShichitaAbstractStroke causes neuronal cell death and destruction of neuronal circuits in the brain and spinal cord. Injury to the brain tissue induces sterile inflammation triggered by the extracellular release of endogenous molecules, but cerebral inflammation after stroke is gradually resolved within several days. In this pro-resolving process, inflammatory cells adopt a pro-resolving or repairing phenotype in the injured brain, activating endogenous repairing programs. Although the mechanisms involv...
Source: Neurochemistry International - October 20, 2018 Category: Neuroscience Source Type: research

Expression and secretion of synaptic proteins during stem cell differentiation to cortical neurons
In this study, expression and secretion of the synaptic proteins, neurogranin (NRGN), growth-associated protein-43 (GAP-43), synaptosomal-associated protein-25 (SNAP-25) and synaptotagmin-1 (SYT-1) were analyzed during cortical neuronal differentiation. Protein levels were measured in cells, modeling fetal cortical development, and cell-conditioned media which was used as a model of cerebrospinal fluid (CSF), respectively. Human iPSC-derived cortical neurons were maintained over a period of at least 150 days, which encompasses the different stages of neuronal development. The differentiation was divided into the following ...
Source: Neurochemistry International - October 19, 2018 Category: Neuroscience Source Type: research

Blockade of IL-6 signaling in neuromyelitis optica
Publication date: Available online 17 October 2018Source: Neurochemistry InternationalAuthor(s): Manabu ArakiAbstractNeuromyelitis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD) are autoimmune diseases associated with a disease-specific autoantibody directed against the water channel protein aquaporin-4. Standard immunotherapy, immunosuppressive agents, and corticosteroids can prevent acute attacks and maintain remission in most patients with NMOSD. However, there is a strong need for additional options for patients who are refractory to standard treatments. Emerging therapies targeting specific molecules ...
Source: Neurochemistry International - October 19, 2018 Category: Neuroscience Source Type: research

Assessment of neuroprotective effects of Gallic acid against glutamate-induced neurotoxicity in primary rat cortex neuronal culture
Publication date: Available online 17 October 2018Source: Neurochemistry InternationalAuthor(s): S. Maya, T. Prakash, Krishna DasAbstractGlutamate excitotoxicity plays a crucial role in the pathogenesis behind the development and progression of several neurodegenerative diseases. The study aimed to investigate the neuroprotective activity of Gallic acid (GA) against glutamate-induced neurotoxicity in primary rat cortex neurons (RCN). Treated the RCNs with GA 25 & 50 μg/ml for 2 h and later treated the cells with 100 μM glutamate (GLU) and incubated for 24 h at 37 °C. The results demonstrated that,...
Source: Neurochemistry International - October 17, 2018 Category: Neuroscience Source Type: research

Susceptibility of the cerebral cortex to spreading depolarization in neurological disease states: The impact of aging
Publication date: Available online 15 October 2018Source: Neurochemistry InternationalAuthor(s): Péter Hertelendy, Dániel P. Varga, Ákos Menyhárt, Ferenc Bari, Eszter FarkasAbstractSecondary injury following acute brain insults significantly contributes to poorer neurological outcome. The spontaneous, recurrent occurrence of spreading depolarization events (SD) has been recognized as a potent secondary injury mechanism in subarachnoid hemorrhage, malignant ischemic stroke and traumatic brain injury. In addition, SD is the underlying mechanism of the aura symptoms of migraineurs. The susceptibili...
Source: Neurochemistry International - October 16, 2018 Category: Neuroscience Source Type: research

Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons
Publication date: Available online 15 October 2018Source: Neurochemistry InternationalAuthor(s): Xinjian Zhang, Taku Nagai, Rijwan Uddin Ahammad, Keisuke Kuroda, Shinichi Nakamuta, Takashi Nakano, Naoto Yukinawa, Yasuhiro Funahashi, Yukie Yamahashi, Mutsuki Amano, Junichiro Yoshimoto, Kiyofumi Yamada, Kozo KaibuchiAbstractMedium spiny neurons (MSNs) expressing dopamine D1 receptor (D1R) or D2 receptor (D2R) are major components of the striatum. Stimulation of D1R activates protein kinase A (PKA) through Golf to increase neuronal activity, while D2R stimulation inhibits PKA through Gi. Adenosine A2A receptor (A2AR) coupled ...
Source: Neurochemistry International - October 15, 2018 Category: Neuroscience Source Type: research

Systemic L-buthionine-S-R-sulfoximine administration modulates glutathione homeostasis via NGF/TrkA and mTOR signaling in the cerebellum
Publication date: Available online 6 October 2018Source: Neurochemistry InternationalAuthor(s): Carla Garza-Lombó, Pavel Petrosyan, Miguel Tapia-Rodriguez, Cesar Valdovinos-Flores, María E. GonsebattAbstractGlutathione (GSH) is an essential component of intracellular antioxidant systems that plays a primordial role in the protection of cells against oxidative stress, maintaining redox homeostasis and xenobiotic detoxification. GSH synthesis in the brain is limited by the availability of cysteine and glutamate. Cystine, the disulfide form of cysteine is transported into endothelial cells of the blood-brain bar...
Source: Neurochemistry International - October 7, 2018 Category: Neuroscience Source Type: research

TRPV1 modulates morphine self-administration via activation of the CaMKII-CREB pathway in the nucleus accumbens
Publication date: Available online 4 October 2018Source: Neurochemistry InternationalAuthor(s): Shi-Xun Ma, Hyoung-Chun Kim, Seok-Yong Lee, Choon-Gon JangAbstractOpioid addiction is a growing problem for public health, and opioids have correspondingly become more heavily regulated over time. We have previously shown that TRPV1 plays a critical role in morphine addiction using a self-administration paradigm in rats, and the current study evaluates the effects of the TRPV1 signaling pathway on morphine self-administration (SA). We found that treatment with a selective TRPV1 antagonist, SB366791, significantly decreased the m...
Source: Neurochemistry International - October 6, 2018 Category: Neuroscience Source Type: research

Bacopa monnieri alleviates paraquat induced toxicity in Drosophila by inhibiting jnk mediated apoptosis through improved mitochondrial function and redox stabilization
Publication date: Available online 5 October 2018Source: Neurochemistry InternationalAuthor(s): Saurabh Srivastav, Mahino Fatima, Amal Chandra MondalAbstractParaquat (PQ) is an organic chemical compound and a member of redox active family of heterocycles. In spite of its high toxicities, it is used as one of the potent herbicide throughout the world. Though its toxic manifestations are observed in different organs, its principal toxic effect is manifested in the brain leading to the development of Parkinsonian symptoms. PQ exposure adversely affects dopaminergic (DA-ergic) neuron-rich region in the substantia nigra pars co...
Source: Neurochemistry International - October 6, 2018 Category: Neuroscience Source Type: research

Chronic high-fat diet-induced obesity in gerbils increases pro-inflammatory cytokines and mTOR activation, and elicits neuronal death in the striatum following brief transient ischemia
The objective of this study was to investigate effects of obesity on neuronal damage and inflammation in the striatum after transient ischemia and to examine the role of mTOR which is involved in the pathogenesis of metabolic and neurological diseases. Gerbils were fed with normal diet (ND) or high-fat diet (HFD) for 12 weeks and subjected to 5 min of transient ischemia. HFD-fed gerbils showed significant increase in body weight, blood glucose level, serum triglycerides, total cholesterol and low-density lipoprotein cholesterol without affecting food intake. Neuronal death/loss in the HFD-fed gerbils occurred in the dors...
Source: Neurochemistry International - October 4, 2018 Category: Neuroscience Source Type: research

DNMT1 and Sp1 competitively regulate the expression of BACE1 in A2E-mediated photo-oxidative damage in RPE cells
Publication date: Available online 28 September 2018Source: Neurochemistry InternationalAuthor(s): Peirong Huang, Junran Sun, Fenghua Wang, Xueting Luo, Hong Zhu, Qing Gu, Xiangjun Sun, Te Liu, Xiaodong SunAbstractNumerous studies have focused on the deteriorate role of amyloid-β (Aβ) on retina, implying the potential pathogenic mechanism underlying age-related macular degeneration (AMD). However, the mechanism underlying the Aβ deposition in AMD patients remains unknown. Beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1), rate-limiting enzyme for Aβ production, plays an important role in A&b...
Source: Neurochemistry International - October 4, 2018 Category: Neuroscience Source Type: research

Gateway reflex: Local neuroimmune interactions that regulate blood vessels
Publication date: Available online 29 September 2018Source: Neurochemistry InternationalAuthor(s): Daisuke Kamimura, Takuto Ohki, Yasunobu Arima, Mitsutoshi Ota, Masaaki MurakamiAbstractNeuroimmunology is a research field that intersects neuroscience and immunology, with the larger aim of gaining significant insights into the pathophysiology of chronic inflammatory diseases such as multiple sclerosis. Conventional studies in this field have so far mainly dealt with immune responses in the nervous system (i.e. neuroinflammation) or systemic immune regulation by the release of glucocorticoids. On the other hand, recently acc...
Source: Neurochemistry International - October 4, 2018 Category: Neuroscience Source Type: research

Nicotinamide Mononucleotide Adenylyltransferase 2 maintains neuronal structural integrity through the maintenance of golgi structure
Publication date: Available online 29 September 2018Source: Neurochemistry InternationalAuthor(s): Tana Pottorf, Alexis Mann, Shaneann Fross, Clayton Mansel, Bhupinder P.S. VohraAbstractGolgi fragmentation and loss of Nicotinamide Mononucleotide Adenylyltransferase 2 (NMNAT2) are the early key features of many neurodegenerative disorders. We investigated the link between NMNAT2 loss, Golgi fragmentation and axon degeneration. Golgi fragmentation in the cultured dorsal root ganglion (DRG) neurons resulted in caspase dependent axon degeneration and neuronal cell death. NMNAT2 depletion in the DRG neurons caused Golgi fragmen...
Source: Neurochemistry International - October 4, 2018 Category: Neuroscience Source Type: research

Interactions of the tricyclic antidepressant drug amitriptyline with L-DOPA in the striatum and substantia nigra of unilaterally 6-OHDA-lesioned rats. Relevance to motor dysfunction in Parkinson's disease
Publication date: Available online 2 October 2018Source: Neurochemistry InternationalAuthor(s): Kinga Kamińska, Tomasz Lenda, Jolanta Konieczny, Jadwiga Wardas, Elżbieta Lorenc-KociAbstractAntidepressant drugs are recommended for the treatment of Parkinson's disease (PD)-associated depression but their role in the modulation of L-DOPA-induced behavioral and neurochemical markers is poorly explored. The aim of the present study was to examine the impact of the tricyclic antidepressant amitriptyline and L-DOPA, administered chronically alone or in combination, on rotational behavior, monoamine levels and binding of radioli...
Source: Neurochemistry International - October 4, 2018 Category: Neuroscience Source Type: research

The effect of age, sex and strains on the performance and outcome in animal models of stroke
Publication date: Available online 3 October 2018Source: Neurochemistry InternationalAuthor(s): Hongxia Zhang, Siyang Lin, Xudong Chen, Lei Gu, Xiaohong Zhu, Yinuo Zhang, Kassandra Reyes, Brain Wang, Kunlin JinAbstractStroke is one of the leading causes of death worldwide, and the majority of cerebral stroke is caused by occlusion of cerebral circulation, which eventually leads to brain infarction. Although stroke occurs mainly in the aged population, most animal models for experimental stroke in vivo almost universally rely on young-adult rodents for the evaluation of neuropathological, neurological, or behavioral outcome...
Source: Neurochemistry International - October 4, 2018 Category: Neuroscience Source Type: research

Behavioral response to imipramine under chronic mild stress corresponds with increase of mRNA encoding somatostatin receptors sst2 and sst4 expression in medial habenular nucleus
Publication date: Available online 3 October 2018Source: Neurochemistry InternationalAuthor(s): Faron-Górecka Agata, Kuśmider Maciej, Solich Joanna, Kolasa Magdalena, Gruca P, Pabian Paulina, Szlachta Marta, Dziedzicka-Wasylewska MartaGraphical abstract (Source: Neurochemistry International)
Source: Neurochemistry International - October 4, 2018 Category: Neuroscience Source Type: research

Uncaria rhynchophylla ameliorates amyloid beta deposition and amyloid beta-mediated pathology in 5XFAD mice
Publication date: Available online 3 October 2018Source: Neurochemistry InternationalAuthor(s): Soo Jung Shin, Yuon Jeong, Seong Gak Jeon, Sujin Kim, Seong-kyung Lee, Hong Seok Choi, Cheong Su Im, Seong Hee Kim, Soo Hwan Kim, Jae Ho Park, Jin-il Kim, Jwa-Jin Kim, Minho MoonAbstractOne of the pathological hallmarks of Alzheimer's disease (AD) is the abnormal aggregation of amyloid beta (Aβ) peptides. Uncaria rhynchophylla (UR), one of the Uncaria species, has long been used to treat neurodegenerative disease. In particular, it has been reported that UR inhibits aggregation of Aβ in vitro. However, little is known ...
Source: Neurochemistry International - October 4, 2018 Category: Neuroscience Source Type: research

Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation in in vitro oxygen glucose deprivation
Publication date: Available online 4 October 2018Source: Neurochemistry InternationalAuthor(s): Gang Luo, Yinuo Huang, Dapeng Mo, Ning Ma, Feng Gao, Ligang Song, Xuan Sun, Xiaotong Xu, Lian Liu, Xiaochuan Huo, Bo Wang, Xiaoqing Li, Baixue Jia, Yiming Deng, Xuelei Zhang, Alejandro Fernandez-Escobar, Guangge Peng, Zhongrong MiaoAbstractSubsequent inflammation in stroke plays an important role in the damage of neurons in the perilesional area. Therapeutic intervention targeting inflammation may be a promising complementary strategy to current treatments of stroke. Here, we explored the possible beneficial effects of tyrosol, ...
Source: Neurochemistry International - October 4, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: November 2018Source: Neurochemistry International, Volume 120Author(s): (Source: Neurochemistry International)
Source: Neurochemistry International - October 4, 2018 Category: Neuroscience Source Type: research

“Polytox” synthetic cathinone abuse: A potential role for organic cation transporter 3 in combined cathinone-induced efflux
Publication date: Available online 21 September 2018Source: Neurochemistry InternationalAuthor(s): Felix P. Mayer, Diethart Schmid, Marion Holy, Lynette C. Daws, Harald H. SitteAbstractSynthetic cathinone derivatives are a new class of psychoactive substances (NPS), also known as “bath salts”, designed to exert psychostimulant effects resembling those of well-known psychostimulants, such as cocaine and 3,4-methylenedionxymethylamphetamine (MDMA, “ecstasy”). As major constituents of bath salts, the cathinone derivatives 3,4-methylenedioxypyrovalerone (MDPV) and 4-methylmethcathinone (mephedrone), hav...
Source: Neurochemistry International - September 22, 2018 Category: Neuroscience Source Type: research

1,8-cineole decreases neuropathic pain probably via a mechanism mediating P2X3 receptor in the dorsal root ganglion
Publication date: Available online 22 September 2018Source: Neurochemistry InternationalAuthor(s): Ya-ling Zhang, Yi-guo Liu, Qing Li, Xiang-dong Wang, Xiao-bo Zheng, Bao-lin Yang, Bin Wan, Jian-min Ma, Zeng-xu LiuAbstract1,8-cineole is a natural monoterpene cyclic ether present in eucalyptus and has been reported to exhibit anti-inflammatory and antioxidant effects. The therapeutic effects of 1,8-cineole on neuropathic pain and the molecular mechanisms of its pharmacological actions remain largely unknown. In the present study, we investigated the analgesic mechanisms of orally administered 1,8-cineole in a rat model of c...
Source: Neurochemistry International - September 22, 2018 Category: Neuroscience Source Type: research

The PPARδ agonist GW0742 restores neuroimmune function by regulating Tim-3 and Th17/Treg-related signaling in the BTBR autistic mouse model
In conclusion, this study suggests that GW0742 corrects neurobehavioral dysfunction in BTBR mice which is concurrent with modulation of multiple signaling pathways. (Source: Neurochemistry International)
Source: Neurochemistry International - September 16, 2018 Category: Neuroscience Source Type: research

Activation of α7 nicotinic acetylcholine receptor alleviates Aβ1-42-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways
Publication date: Available online 11 September 2018Source: Neurochemistry InternationalAuthor(s): Ke-Wei Chang, Hang-Fan Zong, Kai-Ge Ma, Wan-Ying Zhai, Wei-Na Yang, Xiao-Dan Hu, Jie-Hua Xu, Xin-Lin Chen, Sheng-Feng Ji, Yi-Hua QianAbstractAmyloid β peptide 1–42 (Aβ1-42) could induce cognitive deficits through oxidative stress, inflammation, and neuron death in Alzheimer's disease (AD). MAPK pathways have been thought to mediate Aβ1-42-induced neuroinflammation responses, neuron death and cognitive decline in AD. The α7 nicotinic acetylcholine receptor (α7nAChR) exerts a neuroprotective eff...
Source: Neurochemistry International - September 12, 2018 Category: Neuroscience Source Type: research

Neuroprotective effects of levetiracetam, both alone and combined with propylparaben, in the long-term consequences induced by lithium-pilocarpine status epilepticus
Publication date: Available online 10 September 2018Source: Neurochemistry InternationalAuthor(s): César Emmanuel Santana-Gómez, María Guadalupe Valle-Dorado, Ana Esmeralda Domínguez-Valentín, Arely Hernández-Moreno, Sandra Orozco-Suárez, Luisa RochaAbstractStatus epilepticus (SE) is a neurological condition that frequently induces severe neuronal injury in the hippocampus, subsequent epileptogenesis and pharmacoresistant spontaneous recurrent seizures (SRS). The repeated administration of LEV (a broad-spectrum antiepileptic drug) during the post-SE period does not prevent t...
Source: Neurochemistry International - September 11, 2018 Category: Neuroscience Source Type: research

Neuronal Growth Factor regulates brain specific kinase 1 expression by inhibiting promoter methylation and promoting Sp1 recruitment
In conclusion, our results provide evidence of a novel mechanism of Brsk1 transcriptional regulation changing the promoter's methylation status, which was incited by the NGF-induced neuronal differentiation process. (Source: Neurochemistry International)
Source: Neurochemistry International - September 7, 2018 Category: Neuroscience Source Type: research

Knockdown the P2X3 receptor in the stellate ganglia of rats relieved the diabetic cardiac autonomic neuropathy
Publication date: Available online 6 September 2018Source: Neurochemistry InternationalAuthor(s): Xuan Sheng, Yu Dan, Bo Dai, Jingjing Guo, Huihong Ji, Xinge Zhang, Zhi Xie, Siqi Song, Qiwen Pan, Jiayue Wang, Shangdong Liang, Guilin LiAbstractDiabetic cardiac autonomic neuropathy (DCAN) is a common and serious complication of diabetes mellitus (DM), is manifested by nerve fiber injury in the sympathetic and parasympathetic nerve of the autonomic nervous system, and causes hypertension, cardiac arrhythmias, silent myocardial infarction, and sudden death. Our previous study observed that P2X3 receptor in superior cervical ga...
Source: Neurochemistry International - September 7, 2018 Category: Neuroscience Source Type: research

Effect of Angelica polysaccharide on brain senescence of Nestin-GFP mice induced by D-galactose
In conclusion, ASP can delay aging speed by protecting NSCs and promote neurogenesis by enhancing the antioxidant and anti-inflammatory capacity, up-regulation of p53/p21 signaling pathway. As to provide theoretical basis for treatment for brain aging related diseases, add new scientific connotation for “qi and blood theory” and “supplement blood and delay aging” of Traditional Chinese Medicine. (Source: Neurochemistry International)
Source: Neurochemistry International - September 7, 2018 Category: Neuroscience Source Type: research

Model systems for analysis of dopamine transporter function and regulation
Publication date: Available online 1 September 2018Source: Neurochemistry InternationalAuthor(s): Moriah J. Hovde, Garret H. Larson, Roxanne A. Vaughan, James D. FosterAbstractThe dopamine transporter (DAT) plays a critical role in dopamine (DA) homeostasis by clearing transmitter from the extraneuronal space after vesicular release. DAT serves as a site of action for a variety of addictive and therapeutic reuptake inhibitors, and transport dysfunction is associated with transmitter imbalances in disorders such as schizophrenia, attention deficit hyperactive disorder, bipolar disorder, and Parkinson disease. In this review...
Source: Neurochemistry International - September 2, 2018 Category: Neuroscience Source Type: research

The role of decreased cardiolipin and impaired electron transport chain in brain damage due to cardiac arrest
In this study, adult male Sprague-Dawley rats were subjected to asphyxia-induced CA for 30 min or 30 min followed by 60 min CPB resuscitation. Mitochondria were then isolated from brain, heart, kidney, and liver tissues for examination using spectrophotometry and mass spectrometry to measure the activities of mitochondrial electron transport complexes and the cardiolipin content. We found significantly decreased complex I activity in mitochondria isolated from all four organs following CA, while complex III and IV activities remained intact. Following CPB resuscitation, complex I activity was normalized in kidney and...
Source: Neurochemistry International - September 2, 2018 Category: Neuroscience Source Type: research

3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases
Publication date: Available online 1 September 2018Source: Neurochemistry InternationalAuthor(s): Paula Korhonen, Tarja Malm, Anthony R. WhiteAbstractNeurodegenerative disorders have an enormous impact on society and healthcare budgets. There has been a high degree of failure in many recent clinical trials for disease-modifying therapeutics. A major factor in this failure is the difficulty of translating findings from animal-based cell models to human patients. The majority of non-animal neurodegenerative disease research has been conducted in 2 dimensional models of rodent neonatal neurons and glia. While these systems ha...
Source: Neurochemistry International - September 1, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: October 2018Source: Neurochemistry International, Volume 119Author(s): (Source: Neurochemistry International)
Source: Neurochemistry International - August 30, 2018 Category: Neuroscience Source Type: research