Simultaneous quantification of dopamine, serotonin, their metabolites and amino acids by LC-MS/MS in mouse brain following repetitive transcranial magnetic stimulation
Publication date: Available online 10 September 2019Source: Neurochemistry InternationalAuthor(s): Eugenia Z. Poh, Dorothee Hahne, Jessica Moretti, Alan R. Harvey, Michael W. Clarke, Jennifer RodgerAbstractRepetitive Transcranial Magnetic Stimulation (rTMS) is a form of non-invasive brain stimulation that has shown therapeutic potential for various nervous system disorders. In addition to its modulatory effects on neuronal excitability, rTMS is capable of altering neurotransmitter (e.g., glutamate, GABA, dopamine and serotonin) concentrations in cortical and subcortical brain regions. Here we used a modified liquid chromat...
Source: Neurochemistry International - September 12, 2019 Category: Neuroscience Source Type: research

Neuropsychiatric implications of transient receptor potential vanilloid (TRPV) channels in the reward system
Publication date: Available online 5 September 2019Source: Neurochemistry InternationalAuthor(s): Raghunath Singh, Yashika Bansal, Ishwar Parhar, Anurag Kuhad, Tomoko SogaAbstractNeuropsychiatric disorders (NPDs) exert a devastating impact on an individual's personal and social well-being, encompassing various conditions and brain anomalies that influence affect, cognition, and behavior. Because the pathophysiology of NPDs is multifactorial, the precise mechanisms underlying the development of such disorders remain unclear, representing a unique challenge in current neuropsychopharmacotherapy. Transient receptor potential ...
Source: Neurochemistry International - September 6, 2019 Category: Neuroscience Source Type: research

Striatal overexpression of β-arrestin2 counteracts L-dopa-induced dyskinesia in 6-hydroxydopamine lesioned Parkinson's disease rats
Publication date: Available online 3 September 2019Source: Neurochemistry InternationalAuthor(s): Zeng-Rui Zhang, Xing-Ru Zhang, Xiao-Qian Luan, Xin-Shi Wang, Wen-Wen Wang, Xiao-Yi Wang, Bei Shao, Cheng-Long XieAbstractProlonged administration of Levodopa (L-dopa) therapy can generate L-dopa–induced dyskinesia (LID). Accumulating evidence indicates that hyper-activation of the dopamine D1 receptor (D1R) and the cAMP signaling cascade in the medium spiny neurons (MSNs) of the striatum are involved in LID. Previous studies have shown that striatal β-arrestin2 overexpression significantly reduces LID severity and h...
Source: Neurochemistry International - September 3, 2019 Category: Neuroscience Source Type: research

Role of GABAA receptors in EEG activity and spatial recognition memory in aged APP and PS1 double transgenic mice
Publication date: Available online 3 September 2019Source: Neurochemistry InternationalAuthor(s): Yu Fu, Liane Li, Yumei Wang, Guanghui Chu, Xiangyang Kong, Jianhong WangAbstractAlzheimer's disease (AD) is a leading cause of dementia, with no effective treatment currently available. However, targeting the aging mechanism may improve outcomes and γ-aminobutyric acid (GABA) system alteration could have implications for treatment of cognitive decline in old age. We studied the effects of the GABA system on brain activity in aged APP and PS1 transgenic mice. Low dose (0.1 mg/kg i.p.) GABAA agonist muscimol and antagoni...
Source: Neurochemistry International - September 3, 2019 Category: Neuroscience Source Type: research

The physiology and pathophysiology of basal ganglia: from signal transduction to circuits
Publication date: Available online 3 September 2019Source: Neurochemistry InternationalAuthor(s): Nao Chuhma, Kenji F. Tanaka, Taku Nagai (Source: Neurochemistry International)
Source: Neurochemistry International - September 3, 2019 Category: Neuroscience Source Type: research

Mitochondrial movement in Aralar/Slc25a12/AGC1 deficient cortical neurons
In this report, we have investigated the impact of Aralar deficiency on mitochondrial transport in cultured cortical neurons. Aralar/slc25a12/AGC1 is the neuronal isoform of the aspartate-glutamate mitochondrial carrier, a component of the malate-aspartate shuttle (MAS) which plays an important role in redox balance, which is essential to maintain glycolytic pyruvate supply to neuronal mitochondria. Using live imaging microscopy we observed that the lack of Aralar does not affect the number of moving mitochondria nor the Ca2+-induced stop, the only difference being a 10% increase in mitochondrial velocity in Aralar deficie...
Source: Neurochemistry International - August 30, 2019 Category: Neuroscience Source Type: research

Antioxidant cascades confer neuroprotection in ethanol, morphine, and methamphetamine preconditioning
Publication date: Available online 27 August 2019Source: Neurochemistry InternationalAuthor(s): Shuang Lu, Lvshuang Liao, Bing Zhang, Weitao Yan, Liangpei Chen, He Yan, Limin Guo, Shanshan Lu, Kun Xiong, Jie Yan (Source: Neurochemistry International)
Source: Neurochemistry International - August 27, 2019 Category: Neuroscience Source Type: research

Vagus nerve stimulation as a promising adjunctive treatment for ischemic stroke
Publication date: Available online 21 August 2019Source: Neurochemistry InternationalAuthor(s): Jingxi Ma, Peifeng Qiao, Qin Li, Yangyang Wang, Lan Zhang, Liang-Jun Yan, Zhiyou CaiAbstractThe Food and Drug Administration has approved vagus-nerve stimulation (VNS) for the treatment of patients with epilepsy, depression, and headache. By targeting diverse neuroprotective and neuroplasticity pathways, VNS has the potential to be expanded as a treatment for ischemic stroke. VNS has been found to attenuate infarct volume, reduce neurological deficits, and improve memory and cognition in rats with stroke injuries. Some pilot stu...
Source: Neurochemistry International - August 22, 2019 Category: Neuroscience Source Type: research

Astrocyte culture models: Molecular and function characterization of primary culture, immortalized astrocytes and C6 glioma cells
Publication date: Available online 17 August 2019Source: Neurochemistry InternationalAuthor(s): Fabiana Galland, Marina Seady, Jessica Taday, Soraya Soubhi Smaili, Carlos Alberto Gonçalves, Marina Concli LeiteAbstractThe understanding of the physiology of astrocytes and their role in brain function progresses continuously. Primary astrocyte culture is an alternative method to study these cells in an isolated system: in their physiologic and pathologic states. Cell lines are often used as an astrocyte model, since they are easier and faster to manipulate and cost less. However, there are a few studies evaluating the ...
Source: Neurochemistry International - August 19, 2019 Category: Neuroscience Source Type: research

Anti-hyperalgesic effect of (-)-α-bisabolol and (-)-α-bisabolol/β-Cyclodextrin complex in a chronic inflammatory pain model is associated with reduced reactive gliosis and cytokine modulation
This study aimed to evaluate the antinociceptive and anti-inflammatory effect of (-)-α-bisabolol (BIS) alone and complexed with β-cyclodextrin (βCD) in preclinical models of chronic pain. Chronic pain was induced by Freund's Complete Adjuvant (FCA) or partial lesion of the sciatic nerve (PLSN). Swiss mice were treated with BIS, BIS-βCD (50 mg/kg, p.o) or vehicle (control) and mechanical hyperalgesia, thermal hyperalgesia, muscle strength and motor coordination were evaluated. In addition, levels of TNF-α and IL-10 and expression of the ionized calcium-binding adapter protein (IBA-1) were assess...
Source: Neurochemistry International - August 18, 2019 Category: Neuroscience Source Type: research

Danshensu attenuates scopolamine and amyloid-β-induced cognitive impairments through the activation of PKA-CREB signaling in mice
Publication date: Available online 16 August 2019Source: Neurochemistry InternationalAuthor(s): Ho Jung Bae, Kandhasamy Sowndhararajan, Hyeon-Bae Park, So-Yeon Kim, Songmun Kim, Dong Hyun Kim, Ji Woong Choi, Dae Sik Jang, Jong Hoon Ryu, Se Jin ParkAbstractAlzheimer's disease (AD) is an important chronic neurodegenerative disorder and is mainly associated with cognitive dysfunction. At present, bioactive compounds from traditional medicinal plants have received much attention for the enhancement of cognitive function. Danshensu, a phenolic acid isolated from herbal medicines, has various pharmacological activities in the ce...
Source: Neurochemistry International - August 18, 2019 Category: Neuroscience Source Type: research

Alzheimer's disease-like pathology-triggered oxidative stress, alterations in monoamines levels, and structural damage of locus coeruleus neurons are partially recovered by a mix of proteoglycans of embryonic genesis
Publication date: Available online 16 August 2019Source: Neurochemistry InternationalAuthor(s): Michail Aghajanov, Vergine Chavushyan, Senik Matinyan, Margarita Danielyan, Konstantin YenkoyanAbstractAlzheimer's disease (AD) pathogenesis includes oxidative damage and perturbations of monoamines. However, as many details of these alterations are not known, we have investigated the changes in monoamine levels as well as the free radical oxidation processes (FRO) in the brainstem of rats that were administered i.c.v. Aβ (25–35) (rat model of AD-like pathology). The level of oxidative stress was found elevated in the...
Source: Neurochemistry International - August 18, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: October 2019Source: Neurochemistry International, Volume 129Author(s): (Source: Neurochemistry International)
Source: Neurochemistry International - August 18, 2019 Category: Neuroscience Source Type: research

Activation of MORs in the VTA induces changes on cFos expression in different projecting regions: Effect of inflammatory pain
Publication date: Available online 13 August 2019Source: Neurochemistry InternationalAuthor(s): Yolanda Campos-Jurado, Marta Igual-López, Félix Padilla, Teodoro Zornoza, Luis Granero, Ana Polache, Carmen Agustín-Pavón, Lucía HipólitoAbstractChronic pain is a worldwide major health problem and many pain-suffering patients are under opioid based therapy. Epidemiological data show that pain intensity correlates with the risk of misuse of prescription opioids, and other drugs of abuse including alcohol. This increased vulnerability to suffer Substance Use Disorders could be, in part, c...
Source: Neurochemistry International - August 13, 2019 Category: Neuroscience Source Type: research

Neuron specific enolase as a marker of seizure related neuronal injury
ConclusionsNSE a marker of neuronal injury was elevated in patients with acute central nervous system diseases. It is significantly higher in patients with seizures in comparison to those without seizures. This warrants further studies to document aggressive treatment of seizures in acute neurologically ill patients can reduce neuronal damage. (Source: Neurochemistry International)
Source: Neurochemistry International - August 9, 2019 Category: Neuroscience Source Type: research

Proteins or RNA synthesis inhibitors suppressed induction of amnesia developing under impairment of memory reconsolidation by serotonin receptors antagonist
Publication date: Available online 7 August 2019Source: Neurochemistry InternationalAuthor(s): Vladimir P. Nikitin, Svetlana V. Solntseva, Sergey A. Kozyrev, Pavel V. NikitinAbstractStudies have shown that retrieval of long-term memory can cause memory reconsolidation, and impaired reconsolidation leads to amnesia development. However, the mechanisms of amnesia induction due to impaired memory reconsolidation remains poorly described. Using experiments involving grape snails trained to conditioned food aversion, we studied the role of translation and transcription processes and the role of serotonin receptors in the mechan...
Source: Neurochemistry International - August 8, 2019 Category: Neuroscience Source Type: research

Lipid peroxidation biomarkers correlation with medial temporal atrophy in early Alzheimer Disease
Publication date: Available online 6 August 2019Source: Neurochemistry InternationalAuthor(s): Carmen Peña-Bautista, Rogelio López-Cuevas, Ana Cuevas, Miguel Baquero, Consuelo Cháfer-PericásAbstractAlzheimer Disease (AD) is a pathology that causes millions of deaths every year and it also generates severe economic consequences for families and public health systems. Oxidative stress is related to neurodegenerative diseases damage. In fact, brain lipid oxidation could produce brain atrophy. The main objective of this study is the evaluation of atrophy and lipid peroxidation damage in AD patients....
Source: Neurochemistry International - August 6, 2019 Category: Neuroscience Source Type: research

Editorial : Neuroimmunology
Publication date: Available online 1 August 2019Source: Neurochemistry InternationalAuthor(s): Takashi Yamamura (Source: Neurochemistry International)
Source: Neurochemistry International - August 2, 2019 Category: Neuroscience Source Type: research

Somatostatin and cannabinoid receptors crosstalk in protection of huntingtin knock-in striatal neuronal cells in response to quinolinic acid
Publication date: Available online 2 August 2019Source: Neurochemistry InternationalAuthor(s): Shenglong Zou, Ujendra KumarAbstractIn the present study, we describe the status of somatostatin receptor 2 and 5 (SSTR2 and SSTR5) as well as cannabinoid type 1 receptor (CB1R) in Huntingtin (Htt) knock-in striatal neuronal cells. In mutant Htt (mHtt) knock-in (STHdhQ111/111) and wild type (STHdhQ7/7) striatal neuronal cells, SSTRs and CB1R exhibit prominent cytoplasmic expression and respond to agonist in a receptor specific manner. In response to quinolinic acid (QUIN)-induced toxicity, STHdhQ111/111 cells are more vulnerabl...
Source: Neurochemistry International - August 2, 2019 Category: Neuroscience Source Type: research

Neuroprotective natural products against experimental autoimmune encephalomyelitis: A review
Publication date: Available online 31 July 2019Source: Neurochemistry InternationalAuthor(s): Leila Mohtashami, Abolfazl Shakeri, Behjat JavadiGraphical abstract (Source: Neurochemistry International)
Source: Neurochemistry International - August 2, 2019 Category: Neuroscience Source Type: research

5-S-cysteinyl-dopamine, a neurotoxic endogenous metabolite of dopamine: Implications for Parkinson's disease
Publication date: October 2019Source: Neurochemistry International, Volume 129Author(s): Isidro Badillo-Ramírez, José M. Saniger, Selva Rivas-ArancibiaAbstractParkinson's disease (PD) is the second most common neurodegenerative disease worldwide and is characterized for being an idiopathic and multifactorial disease. Extensive research has been conducted to explain the origin of the disease, but it still remains elusive. It is well known that dopamine oxidation, through the endogenous formation of toxic metabolites, is a key process in the activation of a cascade of molecular events that leads to cellular dea...
Source: Neurochemistry International - August 2, 2019 Category: Neuroscience Source Type: research

G37V mutation of Aβ42 induces a nontoxic ellipse-like aggregate: An in vitro and in silico study
Publication date: Available online 30 July 2019Source: Neurochemistry InternationalAuthor(s): Tran Thi Minh Thu, Shu-Hsiang Huang, Ly Anh Tu, Shang-Ting Fang, Mai Suan Li, Yi-Cheng ChenAbstractThe glycine zipper motif at the C-terminus of the β-amyloid (Aβ) peptide have been shown to strongly influence the formation of neurotoxic aggregates. A previous study showed that the G37L mutation dramatically reduces the Aβ toxicity in vivo and in vitro. However, the primary cause and mechanism of the glycine zipper motif on Aβ properties remain unknown. To gain molecular insights into the impact of glycine zipp...
Source: Neurochemistry International - July 31, 2019 Category: Neuroscience Source Type: research

5-S-cysteinyl-dopamine a neurotoxic endogenous metabolite of dopamine: Implications for Parkinson's disease
Publication date: Available online 29 July 2019Source: Neurochemistry InternationalAuthor(s): Isidro Badillo-Ramírez, José M. Saniger, Selva Rivas-ArancibiaAbstractParkinson's disease (PD) is the second most common neurodegenerative disease worldwide and is characterized for being an idiopathic and multifactorial disease. Extensive research has been conducted to explain the origin of the disease, but it still remains elusive. It is well known that dopamine oxidation, through the endogenous formation of toxic metabolites, is a key process in the activation of a cascade of molecular events that leads to cellula...
Source: Neurochemistry International - July 30, 2019 Category: Neuroscience Source Type: research

Homer1/mGluR1-mediated ER stress contributes to lysophosphatidic acid-induced neurotoxicity in cortical neurons
Publication date: Available online 29 July 2019Source: Neurochemistry InternationalAuthor(s): Lin Zhu, Jie Zhu, Shi-Wen GuoAbstractLysophosphatidic acid (LPA) is a glycerophospholipid that can be detected in serum, saliva and cerebrospinal fluid. However, the effect of LPA on neuronal death and survival has not been fully determined. In the present study, we investigated the potential neurotoxic effect of LPA in primary cultured cortical neurons. Treatment with LPA (0.5, 1 and 5 μM) markedly decreased neuronal viability, increased lactate dehydrogenase (LDH) release and promoted apoptosis in cortical neurons. The resu...
Source: Neurochemistry International - July 30, 2019 Category: Neuroscience Source Type: research

Toll-like receptors control p38 and JNK MAPK signaling pathways in rat astrocytes differently, when cultured in normal or high glucose concentrations
Publication date: Available online 29 July 2019Source: Neurochemistry InternationalAuthor(s): Dmitry V. Chistyakov, Nadezda V. Azbukina, Alina A. Astakhova, Artemiy I. Polozhintsev, Marina G. Sergeeva, Georg ReiserAbstractAstrocytes play a vital role in regulating central nervous system inflammation, energy metabolism and brain homeostasis. Unlike macrophages and microglia, which are cells of myeloid ancestry, astrocytes are of ectodermal origin. However, regulatory specificities of signaling pathways connecting inflammatory and metabolic processes are still largely unknown. We analyzed firstly cellular responses to toll-l...
Source: Neurochemistry International - July 30, 2019 Category: Neuroscience Source Type: research

Maternal exposure to swainsonine impaired the early postnatal development of mouse dentate gyrus of offspring
Publication date: Available online 23 July 2019Source: Neurochemistry InternationalAuthor(s): Mengmeng Liu, Mingrui Xu, Mengli Wang, Shuzhong Wang, Kaikai Li, Xinran Cheng, Yongji Wu, Yi Wang, Xiaoyan Zhu, Shanting ZhaoAbstractNeurogenesis in the dentate gyrus (DG) plays a key role in the normal of structure and function of the hippocampus—learning and memory. After eating the locoweeds, animals develop a chronic neurological disease called “locoism”. Swainsonine (SW) is the main toxin in locoweeds. Studies have shown that SW induces neuronal apoptosis in vitro and impairs learning and memory in adult mou...
Source: Neurochemistry International - July 24, 2019 Category: Neuroscience Source Type: research

Brain region specific methylation and Sirt1 binding changes in MAOA promoter is associated with sexual dimorphism in early life stress induced aggressive behavior
Publication date: Available online 24 July 2019Source: Neurochemistry InternationalAuthor(s): Arpita Konar, Mohit Rastogi, Aksheev BhambriAbstractThe maladaptive form of aggressive behavior confers risk for violence and criminal incidences with profound impact on society. Although considerable research has been devoted to elucidate the etiology of aggression, molecular correlates of sex differences remains largely unexplored. Also, little attention has been given to whether males and females respond differently to similar causal factor of aggression. Here, we show the possible association of brain region specific neural ac...
Source: Neurochemistry International - July 24, 2019 Category: Neuroscience Source Type: research

Glutaminase activity in GLS1 het mouse brain compared to putative pharmacological inhibition by ebselen using ex vivo MRS
Publication date: Available online 19 July 2019Source: Neurochemistry InternationalAuthor(s): Lauren Kosten, Golam M. Chowdhury, Susana Mingote, Steven Staelens, Douglas L. Rothman, Kevin L. Behar, Stephen RayportAbstractGlutaminase mediates the recycling of neurotransmitter glutamate, supporting most excitatory neurotransmission in the mammalian central nervous system. A constitutive heterozygous reduction in GLS1 engenders in mice a model of schizophrenia resilience and associated increases in Gln, reductions in Glu and activity-dependent attenuation of excitatory synaptic transmission. Hippocampal brain slices from GLS1...
Source: Neurochemistry International - July 20, 2019 Category: Neuroscience Source Type: research

Phytic acid attenuates upregulation of GSK-3β and disturbance of synaptic vesicle recycling in MPTP-induced Parkinson's disease models
Publication date: Available online 17 July 2019Source: Neurochemistry InternationalAuthor(s): Liping Wang, Zheng Zhang, Lin Hou, YueHua Wang, JinHui Zuo, MeiLan Xue, XiangHong Li, YongChao Liu, JinLian Song, FengYu Pan, TingWei PuAbstractHeightened activity of glycogen synthase kinase-3β (GSK-3β) is linked to the degeneration of dopaminergic neurons in Parkinson's disease (PD). Phytic acid (PA), a naturally occurring compound with potent antioxidant property, has been shown to confer neuroprotection on dopaminergic neurons in PD. However, the underlying mechanism remains unclear. In the present study, MPTP and MP...
Source: Neurochemistry International - July 18, 2019 Category: Neuroscience Source Type: research

Neurovascular interaction
Publication date: Available online 16 July 2019Source: Neurochemistry InternationalAuthor(s): Mika Takarada-Iemata, Peter Westenskow, Rieko Muramatsu (Source: Neurochemistry International)
Source: Neurochemistry International - July 17, 2019 Category: Neuroscience Source Type: research

The role of glutamine in neurogenesis promoted by the green tea amino acid theanine in neural progenitor cells for brain health
Publication date: Available online 13 July 2019Source: Neurochemistry InternationalAuthor(s): Yukio Yoneda, Nobuyuki Kuramoto, Koichi KawadaAbstractThe green tea amino acid theanine is abundant in green tea rather than black and oolong teas, which are all made of the identical tea plant “Chanoki” (Camellia sinensis). Theanine has a molecular structure close to glutamine (GLN) compared to glutamic acid (Glu), in terms of the absence of a free carboxylic acid moiety from the gamma carbon position. Theanine efficiently inhibits [3H]GLN uptake without affecting [3H]Glu uptake in rat brain synaptosomes. In contrast ...
Source: Neurochemistry International - July 14, 2019 Category: Neuroscience Source Type: research

Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion
Publication date: Available online 10 July 2019Source: Neurochemistry InternationalAuthor(s): Elyssa B. Margolis, Anushree N. KarkhanisAbstractNeural circuits that enable an organism to protect itself by promoting escape from immediate threat and avoidance of future injury are conceptualized to carry an “aversive” signal. One of the key molecular elements of these circuits is the kappa opioid receptor (KOR) and its endogenous peptide agonist, dynorphin. In many cases, the aversive response to an experimental manipulation can be eliminated by selective blockade of KOR function, indicating its necessity in transm...
Source: Neurochemistry International - July 12, 2019 Category: Neuroscience Source Type: research

Different epidermal growth factor receptor signaling pathways in neurons and astrocytes activated by extracellular matrix after spinal cord injury
In this study, we built a model of SCI with glial fibrillary acidic protein-green fluorescent protein (GFAP-GFP) and thymus cell antigen 1-yellow fluorescent protein-H (Thy1-YFPH) in mice that express specific transgenes in their astrocytes or neurons. Then, we collected spinal cord neurons or astrocytes by fluorescence-activated cell sorting (FACS). In this way, we investigated the SCI-induced phosphorylation of ERK1/2 and epidermal growth factor receptor (EGFR) in neurons and astrocytes, and we discovered that the SCI-induced EGFR signaling pathways differed between neurons and astrocytes. In the present study, we found ...
Source: Neurochemistry International - July 11, 2019 Category: Neuroscience Source Type: research

Age-related neurochemical and behavioural changes in D409V/WT GBA1 mouse: Relevance to lewy body dementia
This study reports for the first time cognitive impairment by two independent behavioural tests in heterozygous GBA1 mutant mice (D409V/WT) which demonstrate significant cognitive impairment by the age of 12 months. Furthermore, reductions in GBA1 GCase enzyme activity within the brain reflects levels seen in sporadic and GBA1 mutant LBD patients. While there is no overt deposition of Lewy bodies within the hippocampus, alterations to cholinergic machinery and glial proliferation are evident, both pathological features of LBD. Interestingly, we also describe the novel finding of significantly reduced GBA2 GCase enzyme acti...
Source: Neurochemistry International - July 11, 2019 Category: Neuroscience Source Type: research

Chronic oleoylethanolamide treatment attenuates diabetes-induced mice encephalopathy by triggering peroxisome proliferator-activated receptor alpha in the hippocampus
Publication date: Available online 9 July 2019Source: Neurochemistry InternationalAuthor(s): Tong Ren, Jinfeng Liu, Yunlong Ge, Rengong Zhuo, Lu Peng, Feng Liu, Xin Jin, Lichao YangAbstractBrain is a site of diabetic end-organ damage. Diabetes-associated cognitive dysfunction, referred as “diabetic encephalopathy” (DE) has been coined for the patients with type 2 diabetes mellitus showing decline in their cognitive function, especially weak episodic memory, cognitive inflexibility and poor psychomotor performance leading towards Alzheimer's disease. Current evidence supported that aberrant synapses, energy meta...
Source: Neurochemistry International - July 11, 2019 Category: Neuroscience Source Type: research

Age-dependent effects of (+)-MK801 treatment on glutamate release and metabolism in the rat medial prefrontal cortex
In conclusion, the effects of (+)-MK801 treatments on the Glu release/metabolism in the mPFC were found to be age-dependent; and the adult mPFC are likely equipped with more robust neurobiological mechanisms to preserve excitatory-inhibitory balance in response to NMDAR hypofunction. (Source: Neurochemistry International)
Source: Neurochemistry International - July 11, 2019 Category: Neuroscience Source Type: research

PARP inhibition in vivo blocks alcohol-induced brain neurodegeneration and neuroinflammatory cytosolic phospholipase A2 elevations
Publication date: October 2019Source: Neurochemistry International, Volume 129Author(s): Dimitrios E. Kouzoukas, Jennifer A. Schreiber, Nuzhath F. Tajuddin, Simon Kaja, Edward J. Neafsey, Hee-Yong Kim, Michael A. CollinsAbstractChronic alcoholism promotes brain damage that impairs memory and cognition. High binge alcohol levels in adult rats also cause substantial neurodamage to memory-linked regions, notably, the hippocampus (HC) and entorhinal cortex (ECX). Concurrent with neurodegeneration, alcohol elevates poly (ADP-ribose) polymerase-1 (PARP-1) and cytosolic phospholipase A2 (cPLA2) levels. PARP-1 triggers necrosis wh...
Source: Neurochemistry International - July 6, 2019 Category: Neuroscience Source Type: research

Different responses of PC12 cells to different pro-nerve growth factor protein variants
Publication date: Available online 3 July 2019Source: Neurochemistry InternationalAuthor(s): Marzia Soligo, Martina Albini, Federico Lorenzo Bertoli, Valeria Marzano, Virginia Protto, Luisa Bracci-Laudiero, Gaetana Minnone, Fabrizio De Benedetti, Antonio Chiaretti, Elide Mantuano, Luigi ManniAbstractThe present work aimed to explore the innovative hypothesis that different transcript/protein variants of a pro-neurotrophin may generate different biological outcomes in a cellular system. Nerve growth factor (NGF) is important in the development and progression of neurodegenerative and cancer conditions. Mature NGF (mNGF) ori...
Source: Neurochemistry International - July 3, 2019 Category: Neuroscience Source Type: research

Role of NF-κB in cytochrome P450 epoxygenases down-regulation during an inflammatory process in astrocytes
Publication date: Available online 2 July 2019Source: Neurochemistry InternationalAuthor(s): Cynthia Navarro-Mabarak, Irma Mitre-Aguilar, Rafael Camacho-Carranza, Clorinda Arias, Alejandro Zentella-Dehesa, Jesús Javier Espinosa-AguirreAbstractCytochrome P450 (CYP) epoxygenases and their metabolic products, epoxyeicosatrienoic acids (EETs), have been proposed as important therapeutic targets in the brain. However, CYP expression can be modified by the presence of diverse pro-inflammatory cytokines and the subsequent activation of the NF-κB pathway. It has been indicated that CYP epoxygenases are down-regulated ...
Source: Neurochemistry International - July 2, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: September 2019Source: Neurochemistry International, Volume 128Author(s): (Source: Neurochemistry International)
Source: Neurochemistry International - July 2, 2019 Category: Neuroscience Source Type: research

PARP inhibition blocks alcohol-induced neurodegeneration and neuroinflammatory cytosolic phospholipase A2 elevations
Publication date: Available online 25 June 2019Source: Neurochemistry InternationalAuthor(s): Dimitrios E. Kouzoukas, Jennifer A. Schreiber, Nuzhath F. Tajuddin, Simon Kaja, Edward J. Neafsey, Hee-Yong Kim, Michael A. CollinsAbstractChronic alcoholism promotes brain damage that impairs memory and cognition. High alcohol levels in adult rats also cause substantial neurodamage to memory-linked regions, notably, the hippocampus (HC) and entorhinal cortex (ECX). Concurrent with neurodegeneration, alcohol elevates poly (ADP-ribose) polymerase-1 (PARP-1) and cytosolic phospholipase A2 (cPLA2) levels. PARP-1 triggers necrosis whe...
Source: Neurochemistry International - June 26, 2019 Category: Neuroscience Source Type: research

Chrysin ameliorates cerebral ischemia/reperfusion (I/R) injury in rats by regulating the PI3K/Akt/mTOR pathway
In conclusion, our study demonstrated that chrysin might be a potential therapeutic agent for cerebral ischemia. (Source: Neurochemistry International)
Source: Neurochemistry International - June 26, 2019 Category: Neuroscience Source Type: research

Mechanical allodynia induced by optogenetic sensory nerve excitation activates dopamine signaling and metabolism in medial nucleus accumbens
In conclusion, we demonstrated that short, peripheral nerve excitation with mechanical stimulation accelerates the mNAc-specific DA signaling and metabolism which might be associated with the development of mechanical allodynia. (Source: Neurochemistry International)
Source: Neurochemistry International - June 23, 2019 Category: Neuroscience Source Type: research

The unresolved role of mitochondrial DNA in Parkinson's disease: An overview of published studies, their limitations, and future prospects
Publication date: Available online 21 June 2019Source: Neurochemistry InternationalAuthor(s): Amica C. Müller-Nedebock, Rebecca R. Brennan, Marianne Venter, Ilse S. Pienaar, Francois H. van der Westhuizen, Joanna L. Elson, Owen A. Ross, Soraya BardienAbstractParkinson's disease (PD), a progressive neurodegenerative disorder, has long been associated with mitochondrial dysfunction in both sporadic and familial forms of the disease. Mitochondria are crucial for maintaining cellular homeostasis, and their dysfunction is detrimental to dopaminergic neurons. These neurons are highly dependent on mitochondrial adenosine tri...
Source: Neurochemistry International - June 23, 2019 Category: Neuroscience Source Type: research

Enhancement of ATP production ameliorates motor and cognitive impairments in a mouse model of MPTP−induced Parkinson's disease
Publication date: Available online 20 June 2019Source: Neurochemistry InternationalAuthor(s): Hidaka Haga, Kazuya Matsuo, Yasushi Yabuki, Chen Zhang, Feng Han, Kohji FukunagaAbstractApproximately 30–40% of patients with Parkinson's disease (PD) exhibit cognitive impairments. However, there are currently no clinically effective drugs for the treatment of cognitive impairment in patients with PD. Previous studies have suggested that mitochondrial dysfunction such as decreased adenosine triphosphate (ATP) production triggers dopaminergic neurodegeneration in patients with PD and that mitochondria represent a potential t...
Source: Neurochemistry International - June 21, 2019 Category: Neuroscience Source Type: research

Neuroprotective effect of anodal transcranial direct current stimulation on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in mice through modulating mitochondrial dynamics
Publication date: Available online 21 June 2019Source: Neurochemistry InternationalAuthor(s): Sang-Bin Lee, Jinyoung Youn, Wooyoung Jang, Hyun Ok YangAbstractParkinson's disease (PD) is a neurodegenerative disorder characterized by the accumulation of protein inclusions and the loss of dopaminergic neurons. Abnormal mitochondrial homeostasis is thought to be important for the pathogenesis of PD. Transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, constitutes a promising approach for promoting recovery of various neurological conditions. However, little is known about its mechanism of ...
Source: Neurochemistry International - June 21, 2019 Category: Neuroscience Source Type: research

Dexmedetomidine protects neurons from kainic acid-induced excitotoxicity by activating BDNF signaling
In conclusion, these data suggest that dexmedetomidine has the therapeutic potential for treating epilepsy. (Source: Neurochemistry International)
Source: Neurochemistry International - June 18, 2019 Category: Neuroscience Source Type: research

The adenosine A2A receptor antagonist SCH58261 reduces macrophage/microglia activation and protects against experimental autoimmune encephalomyelitis in mice
Publication date: Available online 18 June 2019Source: Neurochemistry InternationalAuthor(s): Yu Chen, Zheng-Xue Zhang, Liu-Pu Zheng, Li Wang, Yin-Feng Liu, Wei-Yong Yin, Yan-Yan Chen, Xin-Shi Wang, Sheng-Tao Hou, Jiang-Fan Chen, Rong-Yuan ZhengAbstractMultiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) affecting more than 2.5 million individuals worldwide. In the present study, myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) mice were treated with adenosine receptor A2A antagonist SCH58261 at different periods of EAE dev...
Source: Neurochemistry International - June 18, 2019 Category: Neuroscience Source Type: research

Involvement of anxiety-like behaviors and brain oxidative stress in the chronic effects of alarm reaction in zebrafish populations
Publication date: Available online 13 June 2019Source: Neurochemistry InternationalAuthor(s): Vanessa A. Quadros, Luiz V. Rosa, Fabiano V. Costa, Talise E. Müller, Flavia V. Stefanello, Vania L. Loro, Denis B. RosembergAbstractAversive conditions elicit anxiety responses that prepare the organism to an eventual threat. Nonetheless, prolonged anxiety is a pathological condition associated with various neuropsychiatric disorders. Here, we evaluated whether the conspecific alarm substance (CAS), a chemical cue that elicits aversion, influences anxiety-like behaviors and modulates brain oxidative stress-related parameters...
Source: Neurochemistry International - June 14, 2019 Category: Neuroscience Source Type: research

The long dystrophin gene product Dp427 modulates retinal function and vascular morphology in response to age and retinal ischemia
In this study, we evaluated the impact of the full-length dystrophin gene product, Dp427, on retinal homeostasis and angiogenesis. Based on the clinical case of a Duchenne muscular dystrophy (DMD) patient who developed severe fibrovascular changes in the retina in response to hypoxic stress, we hypothesized that defects in Dp427 make the retina more susceptible to stresses such as ageing and ischemia. To further study this, a mouse strain lacking Dp427 expression (Mdx) was studied during retinal development, ageing and in the oxygen-induced retinopathy (OIR) model. While retinal vascular morphology was normal during develo...
Source: Neurochemistry International - June 12, 2019 Category: Neuroscience Source Type: research