Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy
AbstractBackgroundWe aimed to assess the efficacy and safety of erenumab, a fully human monoclonal antibody inhibiting the calcitonin gene-related peptide receptor (CGRPr), for the prevention of migraine in a real-life setting.Main bodyWe included in our observational study all patients with episodic or chronic migraine treated with erenumab during the year 2019 in the Abruzzo region, central Italy, and with a 6-month follow-up. We included 89 patients; 76 (85.4%) received 6 doses of erenumab, 11 (12.4%) autonomously withdrew the drug due to perceived inefficacy, and 2 (2.2%) due to adverse events. Seventy-eight patients (...
Source: The Journal of Headache and Pain - April 7, 2020 Category: Neurology Source Type: research

Prospective pilot study to identify psychological factors influencing peri-operative pain in total knee arthroplasty (TKA)
ConclusionsParallel (or anti-parallel) and partially correlated developments of pain improvement and parameters of psychological impairment or coping strategies after TKA suggest a pre-operative screening with tools like the FESV BE and BW or TAS and SOMS questionnaires in order to classify individuals for peri-operative mental training. (Source: International Orthopaedics)
Source: International Orthopaedics - April 7, 2020 Category: Orthopaedics Source Type: research

Identification of symptom clusters and their influencing factors in subgroups of patients with acute exacerbation of chronic obstructive pulmonary disease in a Chinese population
Limited studies have identified symptom clusters (SCs) and their risk factors and the relationships with inflammatory biomarkers in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 7, 2020 Category: Palliative Care Authors: Zhenjiao Yang, Miaoling Cui, Xiaofang Zhang, Jing Bai, Lian Tang, Guirong Tan, Yun Jiang Source Type: research

[Acupuncture for pain and allergic rhinitis-from clinical experience to evidence].
DISCUSSION: As a nonpharmacological procedure, acupuncture is becoming increasingly important in pain and allergy therapy and is therefore increasingly included in current guidelines. In further studies, the efficacy of acupuncture should be determined in other indications and the mechanisms of action of this therapy method should be investigated. PMID: 32266488 [PubMed - as supplied by publisher] (Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz)
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - April 7, 2020 Category: International Medicine & Public Health Authors: Brinkhaus B, Ortiz M, Dietzel J, Willich S Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research

Identification of Symptom Clusters and Their Influencing Factors in Subgroups of Chinese Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Limited studies have identified symptom clusters (SCs) and their risk factors and the relationships with inflammatory biomarkers in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 7, 2020 Category: Palliative Care Authors: Zhenjiao Yang, Miaoling Cui, Xiaofang Zhang, Jing Bai, Lian Tang, Guirong Tan, Yun Jiang Tags: Original Article Source Type: research

Chronic Spinal Pain and Financial Worries in the US Adult Population
Conclusion. This study shows that financial worries were significantly associated with chronic spinal pain. Financial worries may be important to be taken into consideration by clinicians managing patients with spinal pain. More future research is needed to explore the association between financial worries and spinal pain. Level of Evidence: 3 (Source: Spine)
Source: Spine - April 6, 2020 Category: Orthopaedics Tags: EPIDEMIOLOGY Source Type: research

Translation, Cross-cultural Adaptation, and Psychometric Properties of the Hausa Versions of the Numerical Pain Rating Scale and Global Rating of Change Scale in a Low-literate Population With Chronic Low Back Pain
Conclusions. The NPRS and GRCS were successfully adapted into Hausa language with acceptable reliability, validity, and responsiveness. These measures are appropriate for clinical and research use among Hausa-speaking patients. Level of Evidence: 2 (Source: Spine)
Source: Spine - April 6, 2020 Category: Orthopaedics Tags: HEALTH SERVICES RESEARCH Source Type: research

Mechanical Aspects of Intervertebral Disc Injury and Implications on Biomechanics
Conclusion. The mode of loading has an important impact on the severity and nature of failures seen in IVDs and the resulting consequences to biomechanics. However, further research is necessary to better understand to the mechanisms that link injury to degeneration and regeneration of IVD tissues. Level of Evidence: 3 (Source: Spine)
Source: Spine - April 6, 2020 Category: Orthopaedics Tags: LITERATURE REVIEW Source Type: research

The inhibiting role of periaqueductal gray metabotropic glutamate receptor subtype 8 in a rat model of central neuropathic pain.
In this study, we tried to assess the modulatory effect of (S)-3,4-Dicarboxyphenylglycine (DCPG), a metabotropic glutamate receptor subtype 8 (mGluR8) agonist, in a model of chronic central neuropathic pain in male rats. We used a spinal cord contusion method (T6-T8) for the induction of chronic central neuropathic pain.Male Wistar rats were randomly assigned to 5 equal groups (n = 10 per group). Clips compression injury model was used to induce chronic central neuropathic pain. Three weeks after spinal cord injury DCPG, siRNA and normal saline were administered intra-ventrolaterally to the periaqueductal gray (P...
Source: Neurological Research - April 6, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Primary hyperparathyroidism and pancreatitis
ConclusionsWe conclude that pancreatitis can be the only presenting complaint of PHPT. Our study highlights the importance of fully investigating for PHPT in any pancreatitis patient with high normal or raised serum calcium level, especially in the absence of other common causes of pancreatitis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 6, 2020 Category: Endocrinology Source Type: research

A new ultrasound score for the assessment and follow-up of chronic pancreatitis: The ‘Gemelli USCP score’
: Ultrasound (US) is frequently the first line imaging technique used in patients with abdominal pain and clinical suspicion of chronic pancreatitis (CP), but its role in the diagnosis and follow-up of CP is still controversial. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 6, 2020 Category: Gastroenterology Authors: Danilo Pagliari, Maria Elena Ainora, Maria Gabriella Brizi, Marco Cintoni, Emanuele Rinninella, Fabia Attili, Francesco A. Mancarella, Matteo Garcovich, Laura Riccardi, Maurizio Pompili, Antonio Gasbarrini, Riccardo Manfredi, Maria Assunta Zocco Tags: Liver, Pancreas and Biliary Tract Source Type: research

Factors Secreted from Dental Pulp Stem Cells Show Multifaceted Benefits for Treating Experimental Temporomandibular Joint Osteoarthritis
In this study, we aimed to investigate effective therapies to reverse or suppress TMJOA progression. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 6, 2020 Category: Rheumatology Authors: Naoko Ogasawara, Fumiya Kano, Noboru Hashimoto, Hiroki Mori, Liu Yao, Xia Linze, Takuma Sakamaki, Hideharu Hibi, Tsutomu Iwamoto, Eiji Tanaka, Akihito Yamamoto Source Type: research

Do somatic symptoms relate to PTSD and gender after earthquake exposure? A cross-sectional study on young adult survivors in Italy.
CONCLUSION.: This study corroborates a relevant impact of symptomatological PTSD, across both the genders, on somatic symptoms occurring in young adults after months from exposure to a massive earthquake. PMID: 32248878 [PubMed - as supplied by publisher] (Source: CNS Spectrums)
Source: CNS Spectrums - April 6, 2020 Category: Neurology Authors: Carmassi C, Dell'Oste V, Barberi FM, Pedrinelli V, Cordone A, Cappelli A, Cremone IM, Rossi R, Bertelloni CA, Dell'Osso L Tags: CNS Spectr Source Type: research

Treatments for priapism in boys and men with sickle cell disease.
CONCLUSIONS: There is a lack of evidence for the benefits or risks of the different treatments for both stuttering and fulminant priapism in sickle cell disease. This systematic review has clearly identified the need for well-designed, adequately-powered, multicentre randomised controlled trials assessing the effectiveness of specific interventions for priapism in sickle cell disease. PMID: 32251534 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 6, 2020 Category: General Medicine Authors: Chinegwundoh FI, Smith S, Anie KA Tags: Cochrane Database Syst Rev Source Type: research

Early clinical outcomes for treatment of post-thrombotic syndrome and common iliac vein compression with a hybrid Oblique self-expanding nitinol stent - the TOPOS study.
Abstract Background: Physical attributes of conventional stents used in the ilio-caval territory are often unfavorable in the presence of external compression close to the bifurcation. A hybrid oblique stent was developed for the treatment of common iliac vein compression without compromising the contralateral iliac vein inflow. Patients and methods: The ongoing international monitored TOPOS study enrolled 60 patients with post-thrombotic syndrome (PTS) treated with the sinus-Obliquus stent (optimed) and provisional distal stent extension. At 3-month follow-up, patency rates were obtained from duplex ultrasound, ...
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - April 6, 2020 Category: Surgery Authors: Sebastian T, Lichtenberg M, Schlager O, Jalaie H, de Graaf R, Erbel C, Massmann A, Schindewolf M, Grigorean A, Kucher N Tags: Vasa Source Type: research

[Autoinflammatory syndromes and AA amyloidosis].
SO Abstract Autoinflammatory syndromes (AIS) are characterized by uniform attacks often with febrile episodes, exanthema, abdominal pain, muscle and joint pain. Patients show markedly elevated levels of the inflammatory serum parameters C‑reactive protein (CRP) and systemic amyloid A (SAA) during an attack. The origin of the family of the patient and the duration of the attacks are helpful to find the appropriate diagnosis. Molecular genetic tests are used to confirm the clinical diagnosis of an AIS. Colchicine can prevent attacks of familial Mediterranean fever but not the other forms of AIS. In refractory cas...
Source: Zeitschrift fur Rheumatologie - April 6, 2020 Category: Rheumatology Authors: Blank N, Schönland SO Tags: Z Rheumatol Source Type: research

In vivo intrathecal IL-1 β quantification in rats: monitoring the molecular signals of neuropathic pain.
In vivo intrathecal IL-1β quantification in rats: monitoring the molecular signals of neuropathic pain. Brain Behav Immun. 2020 Apr 06;: Authors: Arman A, Deng F, Goldys EM, Liu G, Hutchinson MR Abstract BACKGROUND: Neuropathic pain, or pain after nerve injury, is a disorder with a significant reliance on the signalling of cytokines such as IL-1β. However, quantifying the cytokine release repeatedly over time in vivo is technically challenging. AIM: To evaluate if changes in IL-1β are correlated with the presentation of mechanical allodynia over time, by repeatedly quantifying intr...
Source: Brain, Behavior, and Immunity - April 6, 2020 Category: Neurology Authors: Arman A, Deng F, Goldys EM, Liu G, Hutchinson MR Tags: Brain Behav Immun Source Type: research

Medical Reasons for Marijuana Use, Forms of Use, and Patient Perception of Physician Attitudes Among the US Population
ConclusionAmericans are using marijuana to treat medical conditions despite lack of evidence of efficacy. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - April 6, 2020 Category: Internal Medicine Source Type: research

Coronary Artery Disease: From Mechanism to Clinical Practice.
Authors: Shao C, Wang J, Tian J, Tang YD Abstract In most developed countries, coronary artery disease (CAD), mostly caused by atherosclerosis of coronary arteries, is one of the primary causes of death. From 1990s to 2000s, mortality caused by acute MI declined up to 50%. The incidence of CAD is related with age, gender, economic, etc. Atherosclerosis contains some highly correlative processes such as lipid disturbances, thrombosis, inflammation, vascular smooth cell activation, remodeling, platelet activation, endothelial dysfunction, oxidative stress, altered matrix metabolism, and genetic factors. Risk factors ...
Source: Advances in Experimental Medicine and Biology - April 5, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Safety of calcipotriene and betamethasone dipropionate foam for the treatment of psoriasis.
Authors: Amat-Samaranch V, Puig L Abstract Introduction: Psoriasis vulgaris is a chronic inflammatory skin disease characterized by well-demarcated red and scaly plaques. Most patients have mild disease that is usually controlled with topical treatment. Calcipotriene 0.05% and betamethasone dipropionate 0.064% (Cal/BD) in aerosol foam (Enstilar®) is a novel formulation, which has shown promising results in terms of efficacy and safety.Areas covered: This review evaluates the safety profile of Cal/BD aerosol foam and also the key points regarding to its efficacy. A literature search was performed in PubMed on No...
Source: Expert Opinion on Drug Safety - April 5, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Facial pain – an interdisciplinary challenge
Facial pain – an interdisciplinary challenge Swiss Dent J. 2020 Apr 06;(4):321-327 Authors: Gierthmuehlen M, Gierthmuehlen P, Hugger A, Gierthmuehlen J, Tuerp JC Abstract Acute pain has a warning function and is necessary to survive. Conversely, chronic or recurrent pain is a pathological entity itself and has tremendous impact on the quality of life of the patients . Facial pain is very common and can have various causes. The trigeminal nerve innervates the face, and tumours along its intracranial way as well as peripheral injury can lead to facial pain. Also, infections and systemic diseases, l...
Source: Schweizer Monatsschrift fur Zahnmedizin - April 5, 2020 Category: Dentistry Tags: Swiss Dent J Source Type: research

The mysterious "mental illness" of a philosopher: the case of Blaise Pascal.
Conclusions: Pascal's philosophy reflects his own inner life, which was deeply influenced by the organic affections he suffered. PMID: 32239123 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Translation, Cultural Adaptation and Validation of the Current Opioid Misuse Measure for European Portuguese.
CONCLUSION: The implementation of this questionnaire may reduce the incidence and morbimortality of opioid misuse among chronic pain patients and should improve chronic pain treatment in Portugal. PMID: 32238240 [PubMed - in process] (Source: Acta Medica Portuguesa)
Source: Acta Medica Portuguesa - April 4, 2020 Category: General Medicine Tags: Acta Med Port Source Type: research

[Pain catastrophizing and medication overuse in patients with chronic migraine].
Abstract INTRODUCTION: Migraine is a frequent and debilitating primary headache. Pain catastrophizing is a negative set activated in response to anticipated or actual pain. The anticipatory fear of pain, one of its characteristics, has been associated with a greater prescription and use of analgesics. AIM: To explore the pain catastrophizing in relation to analgesic overuse and the headache impact on quality of life in patients with chronic migraine. PATIENTS AND METHODS: An observational cross-sectional analytical study was performed. Patients older than 18 years with chronic migraine were included, who...
Source: Revista de Neurologia - April 4, 2020 Category: Neurology Authors: Barral E, Buonanotte F Tags: Rev Neurol Source Type: research

Long-term consequences in survivors of critical illness. Analysis of incidence and risk factors.
This study investigates the incidence of long-term consequences in survivors of critical illness 6 months after ICU care. A retrospective analysis of the risk factors was also completed. METHODS: A mixed-method design was used. A qualitative design was used in the questionnaire study (phase 1), and a quantitative design was used for the retrospective study (phase 2). RESULTS: 116 patients were interviewed. Forty-eight patients (41.4%) reported at least one long-term consequence 6 months after ICU discharge. The most frequent consequences were anxiety (n = 33, 28.4%), depression (n = 32, 27.6%) and chronic pain (n =...
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Veterans Team Recovery Integrative Immersion Process (Vet TRIIP): A Qualitative Evaluation of Participation and Impact.
CONCLUSIONS: Evaluative studies on organizations that support Veterans are useful to gauge the effectiveness and impact. Through this study, Veterans expressed perceived strengths and weaknesses of the program so further development and appropriate services will be provided. Similar studies on the impact of non-profit organizations are encouraged. Vet TRIIP significantly impacts the lives of many through stress and pain reduction, potentially preventing suicide. PMID: 32236440 [PubMed - as supplied by publisher] (Source: Military Medicine)
Source: Military Medicine - April 4, 2020 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Reduction of opioid intake after cooled radiofrequency denervation for sacroiliac joint pain: a retrospective evaluation up to 1 year.
Conclusions: CRF denervation of the SIJ can safely elicit pain and disability relief, and reduce opioid use, regardless of intervention success. Future studies may support CRF denervation as a dependable therapy to alleviate opioid use in patients with SIJ-derived LBP and show that opioid use measurements can be a surrogate indicator of pain. PMID: 32235019 [PubMed] (Source: Korean Journal of Pain)
Source: Korean Journal of Pain - April 4, 2020 Category: Anesthesiology Tags: Korean J Pain Source Type: research

Increased calcium-mediated cerebral processes after peripheral injury: possible role of the brain in complex regional pain syndrome.
Conclusions: The calcium-mediated cerebral process occurs after peripheral injury in CRPS, and there can be a relationship between the cerebrum and the pathogenesis of CRPS. PMID: 32235013 [PubMed] (Source: Korean Journal of Pain)
Source: Korean Journal of Pain - April 4, 2020 Category: Anesthesiology Tags: Korean J Pain Source Type: research

Transcutaneous electrical nerve stimulation, acupuncture, and spinal cord stimulation on neuropathic, inflammatory and, non-inflammatory pain in rat models.
Authors: Sato KL, Sanada LS, Silva MDD, Okubo R, Sluka KA Abstract Background: Transcutaneous electrical nerve stimulation (TENS), manual acupuncture (MA), and spinal cord stimulation (SCS) are used to treat a variety of pain conditions. These non-pharmacological treatments are often thought to work through similar mechanisms, and thus should have similar effects for different types of pain. However, it is unclear if each of these treatments work equally well on each type of pain condition. The purpose of this study was to compared the effects of TENS, MA, and SCS on neuropathic, inflammatory, and non-inflammatory ...
Source: Korean Journal of Pain - April 4, 2020 Category: Anesthesiology Tags: Korean J Pain Source Type: research

Spinal cord stimulation in chronic pain: technical advances.
Authors: Isagulyan E, Slavin K, Konovalov N, Dorochov E, Tomsky A, Dekopov A, Makashova E, Isagulyan D, Genov P Abstract Chronic severe pain results in a detrimental effect on the patient's quality of life. Such patients have to take a large number of medications, including opioids, often without satisfactory effect, sometimes leading to medication abuse and the pain worsening. Spinal cord stimulation (SCS) is one of the most effective technologies that, unlike other interventional pain treatment methods, achieves long-term results in patients suffering from chronic neuropathic pain. The first described mode of SCS...
Source: Korean Journal of Pain - April 4, 2020 Category: Anesthesiology Tags: Korean J Pain Source Type: research

Comparative efficacy of medical treatment versus surgical sphincterotomy in the treatment of chronic anal fissure
Conclusion: LIS is still the gold standard for the treatment of chronic anal fissure when the physicians would like to avoid recurrence and obtain the best pain relief. (Source: Nigerian Journal of Clinical Practice)
Source: Nigerian Journal of Clinical Practice - April 4, 2020 Category: Rural Health Authors: T Acar N Acar F G & #252;ng & #246;r E Kamer H Gen & #231; K Atahan ON Dilek M Hac & #305;yanl & #305; Source Type: research

Bilateral calcaneal insufficiency fractures due to chronic carbamazepine use for trigeminal neuralgia: A case report
We report here a 41-year-old lady suffering from bilateral heel pain without trauma history. Her complaining did not respond to analgesics and stretching exercises of plantar fascia. In her past medical history she reported ongoing carbamazepine (CBZ) use over 8 years for trigeminal neuralgia. She had had low bone mineral density; defined as osteopenia. Both calcaneus MRI revealed bilateral stress fractures of calcaneum. She had been advised immobilization for 6 weeks, vitamin D and calcium supplements. CBZ has been stopped by neurology specialist and she had undergone microvascular decompression surgery for intractable pa...
Source: Nigerian Journal of Clinical Practice - April 4, 2020 Category: Rural Health Authors: O Kaya C Hurel G Gumussuyu O Kose Source Type: research

Lack of Data-driven Treatment Guidelines and Wide Variation in Management of Chronic Pelvic Pain in Adolescents and Young Adults
Current literature lacks data-driven guidelines for surgical treatments of adolescents and young adults (AYAs) with chronic pelvic pain. We hypothesized that there is a significant variation in treatment of these patients, which may be an indicator of over or under treatment by some providers. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 4, 2020 Category: OBGYN Authors: Ya-Ching Hung, Maggie L. Westfal, David C. Chang, Cassandra M. Kelleher Source Type: research

A review of discogenic pain management by interventional techniques
Reddy RavikanthJournal of Craniovertebral Junction and Spine 2020 11(1):4-8 This review article describes the various image guided interventional techniques used for treating chronic backache attributed to disc related pathologies. With the aim of minimum invasion and maximum relief, these procedures comprise predominantly of annuloplasty and disc decompression via different mechanisms. Newer therapies are discussed in this review article with the objective of restoring disc height and its biomechanical function by substitution of biochemical constituents, regeneration of cartilaginous end plate and finally artificial dis...
Source: Journal of Craniovertebral Junction and Spine - April 4, 2020 Category: Orthopaedics Authors: Reddy Ravikanth Source Type: research

High ankle sprain: sonographic demonstration of a posterior inferior tibiofibular ligament avulsion
AbstractSyndesmotic injuries, also referred as high ankle sprains, may cause significant ankle instability and chronic pain. Ultrasound (US) is a well-proven imaging modality to evaluate the ligaments of the ankle, due to its high spatial resolution and the possibility to perform dynamic examinations. However, considering the syndesmosis complex, the sonographic appearance of the posterior inferior tibiofibular ligament (PITFL) is not well described in the pertinent literature and, to the best of our knowledge, we found no report of PITFL avulsion demonstrated at US, as in the case presented. (Source: Journal of Ultrasound)
Source: Journal of Ultrasound - April 4, 2020 Category: Radiology Source Type: research

[Giant left ventricular false aneurysme revealing a silent myocardial infarction].
We report a case of a 56-year-old man with a medical history of chronic cigarette smoking, dyslipidemia, and obesity. The patient had no myocardial infarction before. He was admitted for evaluation of important shortness of breath at effort without chest pain for 5 months. Physical exam find an enlarged left ventricular. The electrocardiogram revealed Q waves and ST segment elevation in leads V1 to V6. Transthoracic echocardiogram showed a large thrombosed apical left ventricular false aneurysm, severe left ventricular dysfunction, which were confirmed by cardiac magnetic resonance imaging, this exam also showed no viabili...
Source: Annales de Cardiologie et d'Angeiologie - April 4, 2020 Category: Cardiology Authors: Kadiri R, Fellat N, Doghmi N, Fellat R Tags: Ann Cardiol Angeiol (Paris) Source Type: research

Primary Renal Carcinoid Tumor: Report of Two Cases.
This report describes 2 cases of primary renal carcinoid tumor with unique presentations and management in our regional health care system. Because primary renal carcinoid tumors are quite uncommon, there are no clear established guidelines on preoperative imaging or posttreatment surveillance in patients with these tumors. There remains a large amount of variability in the diagnosis, workup, immunohistochemical analysis, treatment, and surveillance of patients with primary renal carcinoid tumors. As we learn more about this disease, we hope to optimize patient outcomes and standardize pretreatment workup and posttreatment...
Source: The Permanente journal - April 3, 2020 Category: General Medicine Tags: Perm J Source Type: research

Impact of antihypertensive treatment on resiliency to clinical pain
Conclusion: Uncontrollable reduction of high BP in some patients with hypertension could increase the risk for chronic pain incidence and its severity. Practical recommendations in BP control should be reconsidered to take into account patients’ chronic pain. Further research is needed of moderation effects of different antihypertensive manipulations on pain to improve pain management in these patients. (Source: Journal of Hypertension)
Source: Journal of Hypertension - April 3, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Cross-Cultural Adaptation, Reliability and Validity of the Turkish Version of Patient-Specific Functional Scale in Patients with Chronic Neck Pain.
Authors: Yalçinkaya G, Kara B, Arda MN Abstract BACKGROUND/AIM: Current clinical guidelines recommend to use both clinical and self-reported measurements for evaluation of chronic neck pain. Among the self-reported outcomes, Neck Disability Index and Patient Specific Functional Scale are the most widely used and recommended instruments. The purpose of our study was to determine the test-retest reliability and validity of Patient Specific Functional Scale which was not validated in Turkish language previously. MATERIALS AND METHODS: Translation and adaptation process had conducted according to the Beaton ...
Source: Turkish Journal of Medical Sciences - April 3, 2020 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Neck Muscle Stiffness Measured With Shear Wave Elastography in Women With Chronic Nonspecific Neck Pain
Journal of Orthopaedic&Sports Physical Therapy,Volume 50, Issue 4, Page 179-188, April 2020. (Source: The Journal of Orthopaedic and Sports Physical Therapy)
Source: The Journal of Orthopaedic and Sports Physical Therapy - April 3, 2020 Category: Physiotherapy Authors: Angela V. Dieterich Utku Şükrü Yavuz Frank Petzke Antoine Nordez Deborah Falla Source Type: research

Enhanced recovery after spine surgery —a multinational survey assessing surgeons’ perspectives
AbstractBackgroundEnhanced Recovery After Surgery (ERAS) is the object of numerous publications in various surgical fields. Still, its value in spine surgery is not as recognized as it is in other surgical domains. Our aim was to report neurosurgeons ’ opinions about ERAS in spine surgery.MethodsFrom December 2019 to January 2020, members of the European Association of Neurosurgical Societies were asked to complete an online questionnaire regarding ERAS in spine surgery.ResultsN = 234 participants responded to the survey (60% spine neurosurgeons; 22.6% working in private practice). Thirty-two percent re...
Source: Acta Neurochirurgica - April 3, 2020 Category: Neurosurgery Source Type: research

Delayed stabilisation of dynamically unstable syndesmotic injuries results in worse functional outcomes
This study aimed to assess clinical outcomes in patients who required syndesmosis fixation in the presence of arthroscopically proven instability, the hypothesis being that a delay to treatment would be associated with worse function.MethodA retrospective cohort study was performed of patients with dynamic instability requiring fixation between the years of 2010 –2016. The procedures were performed by two foot and ankle fellowship trained orthopaedic surgeons, over three hospital sites. Patients were classified into three groups based on the time since injury to surgery, acute syndesmotic injury (  6 mont...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - April 3, 2020 Category: Orthopaedics Source Type: research

How do the attitudes, confidence, knowledge and understanding differ in pre-registration healthcare students towards treating people with chronic pain: an observational, cross-sectional study
. (Source: European Journal of Physiotherapy)
Source: European Journal of Physiotherapy - April 3, 2020 Category: Rehabilitation Authors: Sean Paul Carroll Nathan Augeard Jacob Tennant Christopher Seenan Source Type: research

The projections from the anterior cingulate cortex to the nucleus accumbens and ventral tegmental area contribute to neuropathic pain-evoked aversion in rats.
Abstract Although the anterior cingulate cortex (ACC) plays a vital role in neuropathic pain-related aversion, the underlying mechanisms haven't been fully studied. The mesolimbic dopamine system encodes reward and aversion, and participates in the exacerbation of chronic pain. Therefore, we investigated whether the ACC modulates aversion to neuropathic pain via control of the mesolimbic dopamine system, in a rat model of chronic constriction injury (CCI) to the sciatic nerve. Using anterograde and retrograde tracings, we confirmed that a subgroup of ACC neurons projected to the nucleus accumbens (NAc) and ventral...
Source: Neurobiology of Disease - April 3, 2020 Category: Neurology Authors: Gao SH, Shen LL, Wen HZ, Zhao YD, Chen PH, Ruan HZ Tags: Neurobiol Dis Source Type: research

Repetitive transcranial magnetic stimulation in traumatic brain injury: evidence from animal and human studies.
Abstract We provide here the first systematic review on the studies dealing with repetitive transcranial magnetic stimulation (rTMS) for traumatic brain injury (TBI) in animals and humans. Several experimental studies in animal models have explored with promising results the use of rTMS to enhance neuroprotection and recovery after TBI. However, there are surprisingly few studies that have obtained substantial evidence regarding effects of rTMS in humans with TBI, many of them are case reports investigating the heterogeneous conditions linked to TBI. The most studies have investigated the effects of rTMS in subjec...
Source: Brain Research Bulletin - April 3, 2020 Category: Neurology Authors: Nardone R, Sebastianelli L, Versace V, Brigo F, Golaszewski S, Manganotti P, Saltuari L, Trinka E Tags: Brain Res Bull Source Type: research

Bilateral fibular head prominence: A case report of bilateral chronic knee pain
Publication date: Available online 10 March 2020Source: Current Medicine Research and PracticeAuthor(s): Deepak Kumar Singhal, Brajesh Nandan, Siddharth Agrawal (Source: Current Medicine Research and Practice)
Source: Current Medicine Research and Practice - April 2, 2020 Category: General Medicine Source Type: research

Concomitant ankle instability has a negative impact on the quality of life in patients with osteochondral lesions of the talus: data from the German Cartilage Registry (KnorpelRegister DGOU)
ConclusionPatients with OCLT with concomitant CAI differ from those without concomitant CAI according to demographic and lesion-related factors. The additional presence of CAI worsens the quality of life of patients with OCLT. Patients with OCLT should be examined for concomitant CAI, so that if CAI is present, it can be integrated into the treatment concept.Level of evidenceIV. (Source: Knee Surgery, Sports Traumatology, Arthroscopy)
Source: Knee Surgery, Sports Traumatology, Arthroscopy - April 2, 2020 Category: Orthopaedics Source Type: research

IJERPH, Vol. 17, Pages 2417: The Implementation Process of Nurse Prescribing in Poland —A Descriptive Study
IJERPH, Vol. 17, Pages 2417: The Implementation Process of Nurse Prescribing in Poland—A Descriptive Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072417 Authors: Zimmermann Cieplikiewicz Wąż Gaworska-Krzemińska Olczyk The study aimed to investigate the situation of nurse prescribing, introduced in Poland in 2016, by analyzing the opinions of nurses, expected to be influential on nurses’ actual practices, in response to legislative change to enable nurses to prescribe and comparing this with actual nurse prescribing behaviours during...
Source: International Journal of Environmental Research and Public Health - April 2, 2020 Category: Environmental Health Authors: Zimmermann Cieplikiewicz W ąż Gaworska-Krzemi ńska Olczyk Tags: Article Source Type: research

Treatment of Psoriasis with Secukinumab in Challenging Patient Scenarios: A Review of the Available Evidence
AbstractPsoriasis (PsO) is a common, systemic, chronic, inflammatory disease characterized by key clinical symptoms, including itching, pain, and scaling. PsO is associated with a high prevalence of comorbidities, including other autoimmune diseases and malignancies. Furthermore, special populations, such as pregnant, pediatric, and elderly patients, and those with erythrodermic PsO, are challenging to treat and require tightly monitored disease and treatment management. Because certain populations have demographic or clinical characteristics that can affect the presentation of PsO and complicate treatment responses, these...
Source: Dermatology and Therapy - April 2, 2020 Category: Dermatology Source Type: research

Identification of intrinsic and reflexive contributions to trunk stabilization in patients with low back pain: a case –control study
ConclusionTrunk stabilization differs between LBP patients and controls, with the same perturbations causing less trunk movement in patients, due to stronger reflexes. We interpret these changes as reflecting protective behavior.Graphic abstractThese slides can be retrieved under Electronic Supplementary Material. (Source: European Spine Journal)
Source: European Spine Journal - April 2, 2020 Category: Orthopaedics Source Type: research