Sleep quality and chronic neck pain: a cotwin study
Journal of Clinical Sleep Medicine,Volume 16, Issue 5, Page 679-687, May 2020. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2020 Category: Sleep Medicine Authors: Alessandro AndreucciJuan J. Madrid-ValeroPaulo H. FerreiraJuan R. Ordo ñana1Center for General Practice at Aalborg University, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark2Arthritis Research UK Primary Care Centre, Research Insti Source Type: research

Investigation of cannabidiol gastro retentive tablets based on regional absorption of cannabinoids in rats.
Abstract The cannabis plant has been widely researched for many therapeutic indications and found to be effective in many chronic conditions such as epilepsy, neuropathic or chronic pain and more. However, biased opinion against compounds of the plant, regulatory as well as compounding challenges have led to very few approved medicinal products. Those formulations which are approved are dosed several times a day, creating an unmet need for controlled release (CR) formulations of cannabinoids. Conventional CR formulations rely on prolonged absorption including the colon. The purpose of this work is to investigate r...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 15, 2020 Category: Drugs & Pharmacology Authors: Izgelov D, Freidman M, Hoffman A Tags: Eur J Pharm Biopharm Source Type: research

Impairment of nociceptive responses after neonatal anoxia correlates with somatosensory thalamic damage: a study in rats.
Abstract Chronic neuropathic pain resulting from damage to the central or peripheral nervous system is a prevalent and debilitating condition affecting 7-18% of the population. Symptoms include spontaneous pain, dysesthesia, paresthesia, allodynia and hyperalgesia. The reported sensory symptoms are comorbid with behavioral disabilities such as insomnia and depression. Neonatal anoxia, a worldwide clinical problem in both neonatal and pediatric care, causes long-term deficits similar to those mentioned. The effect of neonatal anoxia on the maturation of nociceptive pathways has been sparsely explored. To address th...
Source: Behavioural Brain Research - May 15, 2020 Category: Neurology Authors: Kumar AJ, Martins DO, Arruda BP, Lee VY, Chacur M, Nogueira MI Tags: Behav Brain Res Source Type: research

Clinical and anatomopathological features of eosinophilic oesophagitis in children and adults.
allar I, Colás C Abstract INTRODUCTION: Eosinophilic oesophagitis (EoE) is a chronic clinical-pathological disorder with an immunological basis characterised by symptoms of oesophageal dysfunction and, histologically, eosinophilic inflammation. OBJECTIVE: To evaluate the clinical characteristics and differences in children and adults diagnosed with EoE in a tertiary level hospital. METHOD: Descriptive, retrospective and cross-sectional study. We randomly selected 40 children and 40 adults diagnosed with EoE between 2009 and 2016. The patient characteristics were analysed by means of epidemiologica...
Source: Allergologia et Immunopathologia - May 15, 2020 Category: Allergy & Immunology Authors: Agulló-García A, Cubero JL, Lezaun A, Boné J, Guallar I, Colás C Tags: Allergol Immunopathol (Madr) Source Type: research

Disseminated Actinomycosis A Rare Cause of Abdominal Pain: A Case Report.
We report a case of a 59-year-old female who presented to our center with a three-month history of abdominal pain and weight loss. Initial workup revealed the presence of a suspicious hepatic mass, circumferential wall thickening of the transverse colon, and pericardial effusion. Exploratory laparotomy with a surgical biopsy of the hepatic mass was performed, and the histopathologic picture was consistent with actinomycosis. The patient was treated successfully despite the initial diagnostic challenges and complicated hospital course. PMID: 32395260 [PubMed] (Source: Oman Medical Journal)
Source: Oman Medical Journal - May 14, 2020 Category: Middle East Health Tags: Oman Med J Source Type: research

Neuropsychological Changes in Complex Regional Pain Syndrome (CRPS).
de JH Abstract Complex Regional Pain Syndrome (CRPS) is a poorly understood chronic pain condition of multifactorial origin. CRPS involves sensory, motor, and autonomic symptoms primarily affecting one extremity. Patients can also present with neuropsychological changes such as reduced attention to the CRPS-affected extremity, reminiscent of hemispatial neglect, yet in the absence of any brain lesions. However, this "neglect-like" framework is not sufficient to characterise the range of higher cognitive functions that can be altered in CRPS. This comprehensive literature review synthesises evidence of ne...
Source: Behavioural Neurology - May 14, 2020 Category: Neurology Authors: Halicka M, Vittersø AD, Proulx MJ, Bultitude JH Tags: Behav Neurol Source Type: research

Psychometric evaluation of the Persian version of the Doloplus-2 (P-Doloplus-2) scale in elderly with dementia.
This study aimed to translate and evaluate the psychometric properties of Doloplus-2 in the elderly with dementia in Iran. MATERIALS AND METHODS: In this methodological study, after translation and evaluating the face and content validity of Doloplus-2, 100 elderly people were selected by the convenience sampling method in Kashan, 2018-19. Exploratory factor analysis, convergent validity, and known-groups comparison were applied to determine construct validity. Reliability was also assessed through internal consistency, equivalence, and stability methods were used. The ceiling and floor effects were also examined. Data...
Source: Turkish Journal of Medical Sciences - May 14, 2020 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Low-Intensity Pulsed Ultrasound Alleviates Hypoxia-Induced Chondrocyte Damage in Temporomandibular Disorders by Modulating the Hypoxia-Inducible Factor Pathway
Temporomandibular disorders are a common cause of chronic pain in the orofacial region and have a complex and multi-factorial pathophysiology. Mechanical loading or inflammatory conditions have been shown to decrease oxygen tension within the joint cartilage and activate the hypoxia-inducible factor (HIF) pathway, which in turn aggravates the pathological processes underlying temporomandibular joint (TMJ) disorders. We previously showed that low-intensity pulsed ultrasound (LIPUS) treatment effectively repairs TMJ injury induced by chronic sleep deprivation (CSD). Here, we explored the effects of LIPUS treatment on hypoxia...
Source: Frontiers in Pharmacology - May 14, 2020 Category: Drugs & Pharmacology Source Type: research

Interventional Treatment Options for Women with Pelvic Pain
AbstractPurpose of ReviewTo provide an overview of current interventional treatment options for women with chronic pelvic pain (CPP).Recent FindingsAccessibility of CT imaging, ultrasound, and fluoroscopy has assisted the development of novel interventional techniques. Similarly, neuromodulation techniques have improved with the development of novel stimulation patterns and device implants.SummaryNumerous small-scale studies report high success rates with injection intervention therapies in CPP, but there are limited well-designed large-scale studies that demonstrate the superiority of treatment. Female pelvic pain is diff...
Source: Current Physical Medicine and Rehabilitation Reports - May 14, 2020 Category: Rehabilitation Source Type: research

Does intensive interdisciplinary pain treatment improve pediatric headache-related disability?
Abstract Purpose: To examine the effectiveness of intensive interdisciplinary pain treatment for improving disability in children with chronic headache using the International Classification of Functioning, Disability and Health model as a conceptual framework for disability assessment.Materials and methods: Children with chronic headache (n = 50; ages 10-19 years; 62% female) attended an intensive interdisciplinary pain treatment program 8 h/day, 5 times/week for 2-7 weeks. Disability measures were administered at admission, discharge, and 6-8 week follow-up. Disability o...
Source: Disability and Rehabilitation - May 14, 2020 Category: Rehabilitation Authors: Shulman J, Conroy C, Cybulski A, Smith KR, Jervis K, Johnson H, Zurakowski D, Sethna NF Tags: Disabil Rehabil Source Type: research

Readiness of Non-Veteran Health Administration Advanced Practice Registered Nurses to Care for Those Who Have Served: A Multimethod Descriptive Study.
Abstract Federal, state, and educational policy, as well as public and professional initiatives, should influence how care is delivered to veterans from non-Veteran Health Administration (VHA) advanced practice registered nurses (APRNs) located in civilian health care facilities. Due to the MISSION Act, more veterans are receiving care outside the VHA, but little is known about the readiness of APRNs to address the needs of this population. This mixed-methods study describes the perceptions of 340 non-VHA APRNs concerning practice, clinical needs, and challenges they face while delivering care to veterans. Survey ...
Source: Policy, Politics, and Nursing Practice - May 14, 2020 Category: Nursing Authors: Maiocco G, Vance B, Dichiacchio T Tags: Policy Polit Nurs Pract Source Type: research

Serotonergically dependent antihyperalgesic and antiallodynic effects of isoliquiritin in a mouse model of neuropathic pain.
Abstract Chronic neuropathic pain poses a significant health problem worldwide, for which effective treatment is lacking. The current work aimed to investigate the potential analgesic effect of isoliquiritin, a flavonoid from Glycyrrhiza uralensis, against neuropathic pain and elucidate mechanisms. Male C57BL/6J mice were subjected to chronic constriction injury (CCI) by loose ligation of their sciatic nerves. Following CCI surgery, the neuropathic mice developed pain-like behaviors, as shown by thermal (heat) hyperalgesia in the Hargreaves test and tactile allodynia in the von Frey test. Repetitive treatment of C...
Source: European Journal of Pharmacology - May 14, 2020 Category: Drugs & Pharmacology Authors: Yu C, Zhang Y, Gao KX, Sun HT, Gong MZ, Zhao X, Ren P Tags: Eur J Pharmacol Source Type: research

Patient-Reported Outcomes, Physician-Reported Toxicities, and Treatment Outcomes in a Modern Cohort of Patients with Sinonasal Cancer Treated Using Proton Beam Therapy.
CONCLUSIONS: We demonstrate low grade ≥3 toxicity and encouraging disease outcomes with PBT. PROs suggest significant changes in the acute-subacute period without chronic sequelae. PMID: 32417351 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 14, 2020 Category: Radiology Authors: Pasalic D, Ludmir EB, Allen PK, Thaker NG, Chapman BV, Hanna EY, Su SY, Ferrarotto R, Glisson BS, Reddy JP, Brandon Gunn G, Fuller CD, Phan J, Rosenthal DI, Morrison WH, Garden AS, Frank SJ Tags: Radiother Oncol Source Type: research

Are Opioids Needed to Treat Chronic Low Back Pain? A Review of Treatment Options and Analgesics in Development
(Source: Journal of Pain Research)
Source: Journal of Pain Research - May 13, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

A Step Towards a Better Understanding of Pain Phenotypes: Latent Class Analysis in Chronic Pain Patients Receiving Multimodal Inpatient Treatment
(Source: Journal of Pain Research)
Source: Journal of Pain Research - May 13, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Impacts of Fatigue, Stress, and Perceived Health Status on Women With Rheumatic Diseases: A Comparison Study
Conclusions/Implications for Practice The findings support the theory that RDs have a negative impact on perceived stress and fatigue in women. Physical function, bodily pain, and general health may be the most significantly affected domains of perceived physical health in women with RDs. Of note, with the exception of the vitality subscale, RDs did not adversely affect the perceived mental health of participants with RD in this study. Healthcare professionals should cooperate with clinical rheumatologists, psychologists, and physiotherapists to provide comprehensive care that includes long-term education to help patient...
Source: Journal of Nursing Research - May 13, 2020 Category: Nursing Tags: ORIGINAL ARTICLES Source Type: research

The opioid epidemic in pediatrics: a 2020 update
We describe the historical use of opioids and the scope of the current opioid crisis, review the differences between dependence and addiction, and the private and public sectors response to pain management and highlight the issue of adolescent vulnerability. We conclude with a proposal for future directions that address both public and patient health needs. (Source: Current Opinion in Anaesthesiology)
Source: Current Opinion in Anaesthesiology - May 13, 2020 Category: Anesthesiology Tags: PEDIATRIC ANESTHESIA: Edited by Jorge A. Gálvez Source Type: research

Predictors of visit frequency for patients using ongoing chiropractic care for chronic low back and chronic neck pain; analysis of observational data
Chronic spinal pain is prevalent, expensive and long-lasting. Several provider-based nonpharmacologic therapies have now been recommended for chronic low-back pain (CLBP) and chronic neck pain (CNP). However, ... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - May 13, 2020 Category: Orthopaedics Authors: Patricia M. Herman, Sarah E. Edgington, Eric L. Hurwitz and Ian D. Coulter Tags: Research article Source Type: research

Commentary on the article Risk scoring for time to end-stage knee osteoarthritis: data from the Osteoarthritis Initiative
Estimates are that 45% of adult Americans are at risk of developing knee osteoarthritis (KOA) during their lifetime1,2. A chronic disease with no cure, KOA progresses often slowly over the course of many years. Non-surgical treatment options mainly address symptoms, and slow disease progression. End-stage KOA is associated with significant functional limitations and pain, and the course of the disease varies widely across patients3 –6. Defining measurable endpoints along the course of KOA, and being able to predict its progression, are essential to advancing our understanding of KOA and therefore improving medical ca...
Source: Osteoarthritis and Cartilage - May 13, 2020 Category: Rheumatology Authors: H. Ghomrawi, J. Lee Tags: Editorial Source Type: research

A systematic review of the use of acceptance and commitment therapy in supporting parents
ConclusionsDespite these limitations, ACT holds promise as a transdiagnostic intervention that can help with the parenting of children with a range of psychological and physical difficulties.Practitioner points ACT has accrued a relatively strong evidence base for a range of psychological difficulties. Despite some methodological shortcomings, ACT shows promise as an intervention to help parents manage stress and difficulties especially in relation to children with autism, chronic pain, and physical health needs. Further research is required in comparing ACT to more established treatments and helping consolidate initial p...
Source: Psychology and Psychotherapy: Theory, Research and Practice - May 13, 2020 Category: Psychiatry & Psychology Authors: Gary Byrne, Áine Ní Ghráda, Teresa O'Mahony, Emma Brennan Tags: Review Article Source Type: research

Chronic Pain Does Not Impact Baseline Circulating Cytokine Levels in Adults with Sickle Cell Disease.
Abstract Chronic pain affects 50% of adults with sickle cell disease (SCD). Although inflammation is thought to contribute to the pathogenesis of chronic pain, no studies have examined the differences in circulating cytokines between patients with SCD with and without chronic pain. We performed an observational cohort study using blood and urine samples from adults with SCD with and without chronic pain at their usual state of health. We tested the hypothesis that, compared to those without chronic pain, those with chronic pain would have significantly higher baseline circulating proinflammatory cytokines. A total...
Source: Acta Haematologica - May 13, 2020 Category: Hematology Authors: Karafin MS, Simpson P, Field JJ Tags: Acta Haematol Source Type: research

Gluteus maximus tendon transfer for chronic abductor insufficiency: the Geneva technique.
We present the outcomes of a salvage technique for unreconstructable, chronic abductor tears performed by a single surgeon. METHODS: We retrospectively evaluated 38 patients who were surgically managed for chronic abductor insufficiency. Patients without hip implants and patients following primary or revision total hip arthroplasty (THA) were involved. All patients had a Trendelenburg gait, impaired muscle strength of abduction (⩽M4) and fatty degeneration of muscles (Goutallier ⩾3). They underwent transfer of a flap of the anterior third of gluteus maximus to the greater trochanter that was sutured under the slig...
Source: Hip International - May 13, 2020 Category: Orthopaedics Authors: Christofilopoulos P, Kenanidis E, Bartolone P, Poultsides L, Tsiridis E, Kyriakopoulos G Tags: Hip Int Source Type: research

Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia.
Abstract Chronic opioids treatment is impeded by the development of analgesic tolerance and opioid-induced hyperalgesia. Recent studies have shown that multi-functional opioid compounds produce analgesic activities with limited side effects. We developed a novel multi-functional peptide targeting opioid and neuropeptide FF receptors named BN-9, which produced potent and non-tolerance forming antinociceptive effect after supraspinal and systemic administrations. In the present study, the analgesic properties and potential side effects of intrathecal BN-9 were investigated in a range of preclinical rodent models. In...
Source: European Journal of Pharmacology - May 13, 2020 Category: Drugs & Pharmacology Authors: Zhang R, Xu B, Zhang Q, Chen D, Zhang M, Zhao G, Xu K, Xiao J, Zhu H, Niu J, Li N, Fang Q Tags: Eur J Pharmacol Source Type: research

A systematic review of the use of acceptance and commitment therapy in supporting parents
ConclusionsDespite these limitations, ACT holds promise as a transdiagnostic intervention that can help with the parenting of children with a range of psychological and physical difficulties.Practitioner points ACT has accrued a relatively strong evidence base for a range of psychological difficulties. Despite some methodological shortcomings, ACT shows promise as an intervention to help parents manage stress and difficulties especially in relation to children with autism, chronic pain, and physical health needs. Further research is required in comparing ACT to more established treatments and helping consolidate initial p...
Source: Psychology and Psychotherapy: Theory, Research and Practice - May 13, 2020 Category: Psychiatry & Psychology Authors: Gary Byrne, Áine Ní Ghráda, Teresa O'Mahony, Emma Brennan Tags: Review Article Source Type: research

Adaptive and maladaptive coping strategies in older adults with chronic pain after lumbar surgery
This study investigated whether adaptive and maladaptive coping strategies mediate the association between chronic pain and health-related quality of life among older adults experiencing chronic pain after lumbar surgery. Participants were 103 older adults with either or both of chronic lower back pain and leg pain after lumbar surgery (median age = 75 years, men = 44, women = 59). Intensity of chronic lower back and leg pain (11-point numerical rating scale), physical activities (Physical Activity Scale for the Elderly) as an adaptive coping strategy, maladaptive coping strategies (e.g. guarding, resting; Chronic Pain Cop...
Source: International Journal of Rehabilitation Research - May 12, 2020 Category: Rehabilitation Tags: Original Articles Source Type: research

Suicidal ideation and suicide attempt associated with antidepressant and antiepileptic drugs: implications for treatment of chronic pain
Publication date: Available online 11 May 2020Source: Joint Bone SpineAuthor(s): Florian Bailly, Hayat Belaid (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 12, 2020 Category: Orthopaedics Source Type: research

The Brazilian Portuguese version of the Exercise Adherence Rating Scale (EARS-Br) showed acceptable reliability, validity and responsiveness in chronic low back pain
This study aimed to adapt the Exercise Adherence Rating Scale (EARS) into Brazilian Portuguese and evaluate its measurement properties, given as reliability, validity, and responsiveness in patients with non-s... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - May 12, 2020 Category: Orthopaedics Authors: Mariana Romano de Lira, Anamaria Siriani de Oliveira, Roberta Aniceto Fran ça, Ana Claudia Pereira, Emma L. Godfrey and Thais Cristina Chaves Tags: Research article Source Type: research

Acute postoperative pain is correlated with the early onset of postpartum depression after cesarean section: a retrospective cohort study
AbstractThe primary purpose of this study was to evaluate the correlation between the intensity of acute postoperative pain and development of postpartum depression (PPD) after cesarean section (CS). The secondary purpose was to investigate perioperative risk factors for PPD detected in the postoperative period after CS. We retrospectively reviewed 615 women who had undergone CS between January 2017 and October 2019 in our hospital. The incidence of PPD was 22.7% on postoperative day (POD) 5 in the 247 women whose numerical rating scale (NRS) scores on POD3 were available. The severity of acute postoperative pain evaluated...
Source: Journal of Anesthesia - May 12, 2020 Category: Anesthesiology Source Type: research

Effects of the Pilates Method on Kinesiophobia Associated with Chronic Non-Specific Low Back Pain: Systematic Review and Meta-Analysis.
Patients with chronic low back pain with higher levels of kinesiophobia have a 41% greater risk of developing a physical disability. The kinesiophobia model suggests that patients fear movements because of pain, associating movement with worsening of their state. Studies that apply the Pilates method for chronic low back pain achieve positive results in reducing pain and disability, and moderate results regarding kinesiophobia. (Source: Journal of Bodywork and Movement Therapies)
Source: Journal of Bodywork and Movement Therapies - May 12, 2020 Category: Physiotherapy Authors: C íntia Domingues de Freitas, Deborah Araujo Costa, Nelson Carvas Junior, Vinicius Tassoni Civile Tags: Prevention and Rehabilitation Source Type: research

Revision of the Chronic Syndesmotic Injury
This article discusses proper ways of evaluating reduction of the syndesmosis and surgical revision for the chronic injury. (Source: Clinics in Podiatric Medicine and Surgery)
Source: Clinics in Podiatric Medicine and Surgery - May 12, 2020 Category: Podiatry Authors: Sean T. Grambart, Ryan D. Prusa, Katherine M. Ternent Source Type: research

Revision Surgery for the Achilles Tendon
Treatment of Achilles tendon ruptures may be surgical or nonsurgical depending on health, history, age, acuity, and severity of the injury. With chronic or revisional injuries, the best method often requires an open repair with reconstructive soft tissue procedures. Revision surgery can be challenging because of the complexity involving tendinous deficits with nonviable and friable tissue. Surgical treatment is based on tendon approximation, size of the defect, tendon integrity, and functional demands. The goal is to restore anatomic and physiologic tension, provide adequate strength for proper ambulation, optimize functio...
Source: Clinics in Podiatric Medicine and Surgery - May 12, 2020 Category: Podiatry Authors: Amber M. Shane, Christopher L. Reeves, Garrett B. Nguyen, Joshua A. Sebag Source Type: research

How soon can we identify at-risk patients: examining initial depressive symptomology and opioid use in musculoskeletal trauma survivors?
Each year, approximately 2.8 million Americans sustain traumatic musculoskeletal injuries, such as major fractures or amputations. [1] Following the injury, estimates indicate that up to 50-90% of patients develop severe psychological distress long term.[2-5] Distress worsens the self-perceptions of functional gain and efficacy [6] and decreases personal fulfillment and contributes to the development of other health problems, including chronic pain [7] and other comorbid diseases. [8] (Source: Injury)
Source: Injury - May 12, 2020 Category: Orthopaedics Authors: Sharareh Sharififar, Sunny Gupta, Heather K. Vincent, Terrie Vasilopoulos, Laura Zdziarski-Horodyski, MaryBeth Horodyski, Jennifer E. Hagen Source Type: research

circStrn3 is involved in bone cancer pain regulation in a rat model.
In this study, we established a BCP rat model. The von Frey hair test, body weight, and hematoxylin and eosin staining were employed. We screened differentially expressed circRNAs (DECs) between the BCP group and sham group. The results revealed that 850 DECs were significantly up-regulated and 644 DECs were significantly down-regulated in the BCP group. Furthermore, we identified 1177 differentially expressed genes (DEGs) significantly up-regulated and 565 DEGs significantly down-regulated in the BCP group. Gene Ontology annotation of all 1742 DEGs revealed that biological regulation of metabolic processes, cellular proce...
Source: Acta Biochimica et Biophysica Sinica - May 12, 2020 Category: Biochemistry Authors: Zhang Y, Zhang X, Xing Z, Tang S, Chen H, Zhang Z, Li J, Li Y Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research

Factors in the Effectiveness of e-Health Interventions for Chronic Back Pain: How Self-Efficacy Mediates e-Health Literacy and Healthy Habits
Telemedicine and e-Health, Ahead of Print. (Source: Telemedicine and e-Health)
Source: Telemedicine and e-Health - May 12, 2020 Category: Information Technology Authors: Lisa M. Rabenbauer Nils Mevenkamp Source Type: research

Sex Bias and Genotype Influence on Opioid Safety Profile in Chronic Low Back Pain
Conclusions: Sex bias affects female patients resulting in a CLBP diagnostic delay and a different analgesic safety profile. Moreover, the individual’s genetic background might be useful to predict certain AEs in opioid-naive patients under an opioid titration procedure. Addressing sex in necessary to resolve inequalities in health care access. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Contribution of COMT and BDNF Genotype and Expression to the Risk of Transition From Acute to Chronic Low Back Pain
Discussion: CLBP was characterized by higher reported pain burden and augmented hypersensitivity at LBP onset. COMT expression and genotype were associated with acute pain burden and likelihood of transition to CLBP. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Quality of Life in Youth With Chronic Pain: An Examination of Youth and Parent Resilience and Risk Factors
Discussion: The results are discussed in the context of the resilience-risk framework and current understandings of the role of parental factors for pediatric chronic pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Changes in Pain and Psychosocial Functioning and Transition to Chronic Pain in Pediatric Sickle Cell Disease: A Cohort Follow-up Study
This study aimed to: (1) examine changes in pain, psychosocial functioning, and health care utilization among children and adolescents with sickle cell disease (SCD) over a 2-year period and (2) identify baseline biopsychosocial variables associated with the development and maintenance of chronic SCD pain at follow-up. Materials and Methods: Forty-two youth (8 to 18 y old) with SCD completed a battery of self-report measures at baseline and 2-year follow-up. Analgesic, Anesthetic, and Addiction Clinical Trial Translational Innovations Opportunities and Networks and American Pain Society Pain Taxonomy (AAPT) diagn...
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Pain-related Self-efficacy Among People With Back Pain: A Systematic Review of Assessment Tools
Conclusions: Further research should focus on assessing validity and interpretability of these questionnaires, especially in pain-related target groups. Researchers should select questionnaires that are most appropriate for their study aims and the back pain population and contribute to further validation of these scales to best predict future behavior and develop intervention programs. This systematic review aids selection of pain-related assessment tools in back pain both in research and practice. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Review Article Source Type: research

Behavioral and neurophysiological evidence for altered interoceptive bodily processing in chronic pain
Publication date: Available online 11 May 2020Source: NeuroImageAuthor(s): Marco Solcà, Hyeong Dong Park, Fosco Bernasconi, Olaf Blanke (Source: NeuroImage)
Source: NeuroImage - May 11, 2020 Category: Neuroscience Source Type: research

1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain
Chronic pain can be the result of an underlying disease or condition, medical treatment, inflammation, or injury. The number of persons experiencing this type of pain is substantial, affecting upwards of 50 mi... (Source: Molecular Brain)
Source: Molecular Brain - May 11, 2020 Category: Neuroscience Authors: Yuan Zhou, Song Cai, Kimberly Gomez, E. M. Kithsiri Wijeratne, Yingshi Ji, Shreya S. Bellampalli, Shizhen Luo, Aubin Moutal, A. A. Leslie Gunatilaka and Rajesh Khanna Tags: Research Source Type: research

A cross-sectional study of nausea in functional abdominal pain: relation to mucosal mast cells and psychological functioning
Nausea is a common symptom in youth with chronic abdominal pain. The aims of the current study were to assess: 1) the frequency of nausea in patients with functional dyspepsia (FD) and irritable bowel syndrome... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - May 11, 2020 Category: Gastroenterology Authors: Craig Friesen, Meenal Singh, Vivekanand Singh and Jennifer V. Schurman Tags: Research article Source Type: research

Usual care including home exercise with versus without spa therapy for chronic low back pain: protocol for the LOMBATHERM ’ study, a multicentric randomised controlled trial
Low back pain is highly prevalent and a major source of disability worldwide. Spa therapy is frequently used to treat low back pain, but the associated level of evidence for efficacy is insufficient. To fill t... (Source: Trials)
Source: Trials - May 11, 2020 Category: General Medicine Authors: Romain Forestier, Carey Suehs, Alain Fran çon, Marc Marty, Stéphane Genevay, Jérémie Sellam, Claire Chauveton, Fatma Begüm Erol Forestier and Nicolas Molinari Tags: Study protocol Source Type: research

New Developments in Non-invasive Brain Stimulation in Chronic Pain
This article reviews the current evidence for the use of transcranial direct current (tDCS) and repetitive transcranial magnetic stimulation (rTMS) to improve outcomes in chronic pain. Finally, we introduce the reader to novel stimulation methods that may improve therapeutic outcomes in chronic pain.Recent FindingsWhile tDCS is approved for treatment of fibromyalgia in Canada and the European Union, no NIBS method is currently approved for chronic pain in the USA. Increasing sample sizes in randomized clinical trials (RCTs) seems the most efficient way to increase confidence in initial promising results. Trends at funding ...
Source: Current Physical Medicine and Rehabilitation Reports - May 11, 2020 Category: Rehabilitation Source Type: research

IJERPH, Vol. 17, Pages 3324: Physician-Delivered Pain Neuroscience Education for Opioid Tapering: A Case Report
We describe the case of a 75-year-old female with chronic low back pain (CLBP), on opioids for more than 15 years. She presented with an acute episode of nausea, vomiting, abdominal pain, and shortness of breath. After a complete work-up, it was concluded that her presenting symptoms were likely due to her high levels of CLBP and high dose opioids. At the time of intervention, her opioid dosage was between 50–90 MME (Morphine milligram equivalent) (Norco 8 × 7.5 mg/day + Fentanyl 12 mcg patch). She was subsequently seen by the physician for seven outpatient internal medicine appointments over ni...
Source: International Journal of Environmental Research and Public Health - May 11, 2020 Category: Environmental Health Authors: Vikas Agarwal Adriaan Louw Emilio J. Puentedura Tags: Case Report Source Type: research

Surgical management of chronic pelvic instability following periacetabular osteotomy nonunion.
CONCLUSIONS: To our knowledge, this is the largest case series of surgically managed PAO nonunion. Pelvic instability resulting from nonunion and stress fracture can be satisfactorily addressed by mobilising, grafting and plating the nonunion at the superior pubic ramus. The modified Stoppa approach is suitable in most cases, allowing excellent exposure whilst minimising the insult to soft tissues. The altered anatomy of the pelvis following PAO should be anticipated to reduce the risk to nearby neurovascular structures. PMID: 32390565 [PubMed - as supplied by publisher] (Source: Hip International)
Source: Hip International - May 11, 2020 Category: Orthopaedics Authors: Shearman AD, Hashemi-Nejad A, Bankes MJ, Lewis AD Tags: Hip Int Source Type: research

Chemotherapy-induced peripheral neuropathy: part 1-current state of knowledge and perspectives for pharmacotherapy.
CONCLUSIONS: The prevalence of CIPN, potential causes, risk factors, symptoms and molecular mechanisms underlying this pharmacoresistant condition are discussed. PMID: 32394362 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 11, 2020 Category: Drugs & Pharmacology Authors: Sałat K Tags: Pharmacol Rep Source Type: research

CCR4 antagonist (C021) influences the level of nociceptive factors and enhances the analgesic potency of morphine in a rat model of neuropathic pain.
Abstract Neuropathic pain is a chronic condition which significantly reduces the quality of life and serious clinical issue that is in general resistant to available therapies. Therefore looking for new analgesics is still critical issue. Recent, studies have indicated that chemokine signaling pathways are crucial for the development of neuropathy; however, the role of CC chemokine receptor 4 (CCR4) in this process has not yet been studied. Therefore, the aim of our research was to investigate the influence of C021 (a CCR4 antagonist) and CCR4 CC chemokine ligands 17 and 22 (CCL17 and CCL22) on the development of ...
Source: European Journal of Pharmacology - May 11, 2020 Category: Drugs & Pharmacology Authors: Bogacka J, Popiolek-Barczyk K, Pawlik K, Ciechanowska A, Makuch W, Rojewska E, Dobrogowski J, Przeklasa-Muszynska A, Mika J Tags: Eur J Pharmacol Source Type: research

A long-term follow-up of primary hepatic mucosa-associated lymphoid tissue lymphoma
A 37-year-old man with a history of chronic hepatitis B presented with a 1-week history of mild right upper quadrant pain. Five years prior, an echo scan using color Doppler enhancement had revealed a right hepatic tumor measuring 9  cm, penetrated by the portal vein and hepatic vein (Fig. 1A black arrow). The laboratory results were normal. A current (ie, 5 years later) computed tomography scan revealed a well-defined low-density hepatic mass with penetration of the portal vein and hepatic vein in the venous and delayed phas es (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 10, 2020 Category: Gastroenterology Authors: Yang-Yuan Chen, Yung-Fang Chen, Chih-Hsuan Chen Tags: Image of the Month Source Type: research

Effects of COVID-19 lockdown on chronic drug-resistant pain patients treated using brain stimulation approach
Chronic pain often shows insufficient response to pharmacological treatments. Non-invasive brain stimulation (NIBS) of the motor cortex has been proposed as an alternative therapeutic approach [1,2]. This therapeutic intervention requires repeated NIBS sessions once-daily for 1 or 2 weeks followed by a maintenance protocol [2-4]. In our hospital, we usually apply ten NIBS daily sessions (two weeks, Monday to Friday); we will refer to this period as induction phase. After the induction phase, responsive subjects enter into the maintenance phase. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - May 10, 2020 Category: Neurology Authors: Angela Brocalero-Camacho, Yolanda.A. P érez-Borrego, Vanesa Soto-León, Antonio Oliviero, María.Jesús Rodriguez-Matas, Guglielmo Foffani Source Type: research