Sensors, Vol. 20, Pages 2902: A Practical Sensor-Based Methodology for the Quantitative Assessment and Classification of Chronic Non Specific Low Back Patients (NSLBP) in Clinical Settings
This study aimed to classify chronic nonspecific low back pain (NSLBP) patients using our previously developed and validated wearable inertial sensor (SHARIF-HMIS) for the assessment of trunk kinematic parameters. One hundred NSLBP patients consented to perform repetitive flexural movements in five different planes of motion (PLM): 0° in the sagittal plane, as well as 15° and 30° lateral rotation to the right and left, respectively. They were divided into three subgroups based on the STarT Back Screening Tool. The sensor was placed on the trunk of each patient. An ANOVA mixed model was c...
Source: Sensors - May 20, 2020 Category: Biotechnology Authors: Mehrdad Davoudi Seyyed Mohammadreza Shokouhyan Mohsen Abedi Narges Meftahi Atefeh Rahimi Ehsan Rashedi Maryam Hoviattalab Roya Narimani Mohamad Parnianpour Kinda Khalaf Tags: Article Source Type: research

Evaluation of the effects of photobiomodulation therapy and ozone applications after gingivectomy and gingivoplasty on postoperative pain and patients ’ oral health-related quality of life
In this study, 36 patients with chronic inflammatory gingival enlargement underwent gingivectomy and gingivoplasty. The groups were randomly divided into control (n = 12), PBM (n = 12) and ozone (n = 12) groups. GaAlAs diode laser 810 nm wavelength at a non-contact and continuous mode with a power of 0.3 W and a density of 4 J/cm2 used for PBM for 1  min. Ozone was applied for 1 min for every 5 mm2 in contact mode at power level 9 using probe number 3. PBM and ozone applications were performed immediately after the operation, on the 3rd and 7th days. P...
Source: Lasers in Medical Science - May 20, 2020 Category: Laser Surgery Source Type: research

Gaps in opioid prescription for severe breathlessness in hospitalised patients with chronic obstructive pulmonary disease or interstitial lung disease
Breathlessness is the predominant and debilitating symptom in patients with advanced chronic respiratory diseases, including COPD and ILD. The “chronic breathlessness syndrome” has recently been defined as breathlessness at rest or on exertion that leads to disability, despite optimal medical treatment (1). In addition to conventional disease-directed therapy, there is conflicting evidence suggesting (and some guidelines recommend) low -dose, oral opioids may be useful for palliating chronic severe breathlessness in ILD patients and stable outpatients with advanced COPD (2-5). (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - May 20, 2020 Category: Palliative Care Authors: Xinye Chen, Darran Treanor, Brian Le, Natasha Smallwood Tags: Letter Source Type: research

Interplay between body schema, visuospatial perception and pain in patients with spinal cord injury
ConclusionThese results suggest an interplay between lower body scheme distorsions and pain in patients with spinal cord injury. (Source: European Journal of Pain)
Source: European Journal of Pain - May 20, 2020 Category: Anesthesiology Authors: Thomas Osinski, Valeria Martinez, Djamel Bensmail, Samar Hatem, Didier Bouhassira Tags: ORIGINAL ARTICLE Source Type: research

Low back pain in athletes can be controlled with acupuncture by a catecholaminergic pathway: clinical trial.
CONCLUSION: EA activates the sympathetic nervous system and induces the release of epinephrine, which could ameliorate inflammation and protect muscular tissue in addition to relieving pain. PMID: 32429680 [PubMed - as supplied by publisher] (Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society)
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - May 20, 2020 Category: Complementary Medicine Authors: Arriaga-Pizano L, Gómez-Jiménez DC, Flores-Mejía LA, Pérez-Cervera Y, Solórzano-Mata CJ, López-Macías C, Isibasi A, Torres-Rosas R Tags: Acupunct Med Source Type: research

Efficacy and safety of duloxetine in osteoarthritis or chronic low back pain? The tip of an iceberg!
Weng and colleagues must be commended for their attempts to clarify the benefit/harm ratio of duloxetine in osteoarthritis and chronic low back pain1. Indeed, the high number of therapeutic options available shows the state of affairs is a lottery while these frequent conditions “associated with substantial work disability, morbidity, costs, and increased mortality rates” deserve robust evidence2. However, their conclusion “Duloxetine had modest to moderate effects… with mild adverse events” claiming “future randomized controlled trials should focus on comparing duloxetine…&rdquo...
Source: Osteoarthritis and Cartilage - May 20, 2020 Category: Rheumatology Authors: A. Braillon Tags: Letter to the Editor Source Type: research

Health-Related Quality of Life Among Middle-Aged Adults With Chronic Ankle Instability, Copers, and Uninjured Controls.
Abstract CONTEXT: People with chronic ankle instability (CAI) display a lower regional and global health-related quality of life (HRQoL). Examinations of HRQoL outcomes associated with CAI have addressed younger adults, restricting our understanding of the long-term consequences of CAI. OBJECTIVE: To compare ankle regional and global HRQoL in middle-aged participants with and those without CAI. DESIGN: Cross-sectional study. SETTING: Laboratory. PATIENTS OR OTHER PARTICIPANTS: A total of 59 middle-aged volunteers, consisting of 18 with CAI (age = 50.2 ± 9.3 years), 17 who were ankle-spra...
Source: J Athl Train - May 20, 2020 Category: Sports Medicine Authors: Kosik KB, Johnson NF, Terada M, Thomas-Fenwick AC, Mattacola CG, Gribble PA Tags: J Athl Train Source Type: research

Personalizing education: The clinical reasoning processes of physiotherapists using education for the treatment of people with chronic low back pain.
Conclusion: The findings highlight how communication and interaction underpin the clinical reasoning process for using education with people who have CLBP. Participating physiotherapists explored and made sense of a person's world before tailoring their educational approach for the individual. Physiotherapists can use this paper to reflect on their practice to inform their own clinical reasoning. PMID: 32431203 [PubMed - as supplied by publisher] (Source: Physiotherapy Theory and Practice)
Source: Physiotherapy Theory and Practice - May 20, 2020 Category: Physiotherapy Authors: Horler C, Hebron C, Martyn K Tags: Physiother Theory Pract Source Type: research

[Chronic pain syndromes and other persistent functional somatic symptoms].
Abstract Somatic symptoms including pain are everyday human experiences. They usually result from a complex interaction of stimuli, interpretation and reaction, and are not necessarily proportional to structural damage. Persistent functional somatic symptoms can be associated with a significant impairment of quality of life and functioning, even without mental or somatic comorbidity. Dysfunctional experiences, expectancies and behavior, not only by patients but also by physicians, can increase the risk of chronification. From the outset, management should be graded with respect to the severity and biopsychoso...
Source: Der Nervenarzt - May 20, 2020 Category: Neurology Authors: Roenneberg C, Henningsen P, Hausteiner-Wiehle C Tags: Nervenarzt Source Type: research

ASP8477, a fatty acid amide hydrolase inhibitor, exerts analgesic effects in rat models of neuropathic and dysfunctional pain.
Abstract Exogenous cannabinoid receptor agonists are clinically effective for treating chronic pain but frequently cause side effects in the central nervous system. Fatty acid amide hydrolase (FAAH) is a primary catabolic enzyme for anandamide, an endogenous cannabinoid agonist. 3-Pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate (ASP8477) is a potent and selective FAAH inhibitor that is orally active and able to increase the brain anandamide level and is effective in rat models of neuropathic and osteoarthritis pain without causing motor coordination deficits. In the present study, we examined the pharmacokinet...
Source: European Journal of Pharmacology - May 20, 2020 Category: Drugs & Pharmacology Authors: Kiso T, Watabiki T, Sekizawa T Tags: Eur J Pharmacol Source Type: research

Targeted Muscle Reinnervation Improves Residual Limb Pain, Phantom Limb Pain, and Limb Function: A Prospective Study of 33 Major Limb Amputees.
Abstract BACKGROUND: Targeted muscle reinnervation is an emerging surgical technique to treat neuroma pain whereby sensory and mixed motor nerves are transferred to nearby redundant motor nerve branches. In a recent randomized controlled trial, targeted muscle reinnervation was recently shown to reduce postamputation pain relative to conventional neuroma excision and muscle burying. QUESTIONS/PURPOSES: (1) Does targeted muscle reinnervation improve residual limb pain and phantom limb pain in the period before surgery to 1 year after surgery? (2) Does targeted muscle reinnervation improve Patient-reported Outc...
Source: Clinical Orthopaedics and Related Research - May 20, 2020 Category: Orthopaedics Authors: Mioton LM, Dumanian GA, Shah N, Qiu CS, Ertl WJ, Potter BK, Souza JM, Valerio IL, Ko JH, Jordan SW Tags: Clin Orthop Relat Res Source Type: research

Predictors of Psychological Outcomes and the Effectiveness and Experience of Psychological Interventions for Adult Women with Chronic Pelvic Pain: A Scoping Review
(Source: Journal of Pain Research)
Source: Journal of Pain Research - May 19, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Demographic Characteristics Among Patients With Chronic Exertional Compartment Syndrome of the Lower Leg.
Authors: Rynkiewicz KM, Fry LA, DiStefano LJ Abstract Clinical Scenario: Chronic exertional compartment syndrome (CECS) is a condition related with ischemia of the body's tissue due to increases in intracompartmental pressures, which involves, among other symptoms, pain with exertion. CECS is often overlooked or misdiagnosed due to an ambiguous presentation. Diagnostic accuracy of CECS and subsequent management can be improved when contributing factors are known. Research is lacking on the type of patient most likely to experience CECS, highlighting the need for identification of common demographic characteristics ...
Source: Journal of Sport Rehabilitation - May 19, 2020 Category: Sports Medicine Tags: J Sport Rehabil Source Type: research

Proposition of standardized protocol for photodynamic therapy for vulvar lichen sclerosus.
CONCLUSION: Based on a literature review we suggest the following protocol for PDT in VLS: 5% 5-ALA as a photosensitizer applied for three hours under occlusion before irradiation at the dose of 120 J/cm2 with red light (590-760 nm) and intensity of 204 mW/cm2. PMID: 32420789 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

IJERPH, Vol. 17, Pages 3560: Exploring Changes in Activity Patterns in Individuals with Chronic Pain
ez Ruíz-Párraga Peters Esteve This longitudinal study explored whether activity patterns change over time in a sample of 56 individuals with chronic musculoskeletal pain over a 15-day period. Once a day, the participants recorded their level of pain intensity and the degree to which they had engaged in several specific activity patterns. Linear mixed models with random coefficients were used to investigate the rate of change in the activity patterns. Age, sex, pain intensity, and pain duration were controlled. The results show that excessive persistence was the only self-reported activity pattern...
Source: International Journal of Environmental Research and Public Health - May 19, 2020 Category: Environmental Health Authors: Serrano-Ib áñez Bendayan Ram írez-Maestre L ópez-Martínez Ru íz-Párraga Peters Esteve Tags: Article Source Type: research

Quality of life changes with duration of chronic breathlessness: a random sample of community-dwelling people
Chronic breathlessness is associated with poorer quality of life. This population study aimed to define dimensions of quality of life (QoL), and duration and dominant causes of breathlessness that most diminished QoL. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - May 19, 2020 Category: Palliative Care Authors: David C. Currow, Sungwon Chang, Eleonora Dal Grande, Diana H. Ferreira, Slavica Kochovska, Irina Kinchin, Miriam J. Johnson, Magnus Ekstrom Source Type: research

Patient safety incidents involving transdermal opioids: data from the Danish Patient Safety Database
Conclusion This study has demonstrated that the administration of transdermal opioids is challenging and may cause harm, particularly in the primary care sector. To improve patient safety, optimized systems, including guidelines on drug management and the continuing education of healthcare personnel in transdermal opioid management, are necessary. These guidelines should preferably incorporate reminders and checklists, since the omission of doses was the most reported problem. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 19, 2020 Category: Drugs & Pharmacology Source Type: research

Neurogeriatrics-a  vision for improved care and research for geriatric patients with predominating neurological disabilities.
This article discusses how neurological know-how could be integrated in academic geriatric medicine to improve care of neurogeriatric patients, to foster neurogeriatric research and training concepts and to provide innovative care concepts for geriatric patients with predominant neurological conditions and disabilities. PMID: 32430766 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gerontologie und Geriatrie)
Source: Zeitschrift fur Gerontologie und Geriatrie - May 19, 2020 Category: Geriatrics Authors: Jacobs AH, Emmert K, Baron R, Bartsch T, Bauer J, Becker C, Berg D, Bergmann P, Boetzel K, Bollheimer C, Deuschl G, Djukic M, Drey M, Durwen H, Ebersbach G, Elshehabi M, Geritz J, Gisinger C, Guennewig T, Hauptmann B, Heppner HJ, Hobert MA, Hofmann W, Hue Tags: Z Gerontol Geriatr Source Type: research

Use of Erector Spinae Plane Block in Thoracic Surgery Leads to Rapid Recovery from Anesthesia.
The objective of this study was to compare Erector Spinae Plane blocks (ESP) with intercostal blocks (ICB) as part of multi-modal analgesia in quality of postoperative pain control and preservation of pulmonary function after VATS. METHODS: A consecutive cohort of patients undergoing elective VATS were enrolled in the study and divided into the ESP and ICB block groups. Spirometry and visual analog pain scores (VAS) exams were performed to measure Forced Vital Capacity (FVC), Forced Expiratory Volume at one second (FEV1), FEV1/FVC ratio, and Forced Expiratory Flow in intervals 25% to 75% (FEF25-75). Chronic pain was a...
Source: The Annals of Thoracic Surgery - May 19, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Chaudhary O, Baribeau Y, Urits I, Sharkey A, Rashid R, Hess P, Krumm S, Fatima H, Zhang Q, Gangadharan S, Mahmood F, Matyal R Tags: Ann Thorac Surg Source Type: research

Mediators of Pain and Physical Function in Female and Male Patients with Chronic Pain
(Source: Journal of Pain Research)
Source: Journal of Pain Research - May 18, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Calcifying Fibrous Tumor of the Neck
This article describes a case of CFT which presented as an enlarging neck mass in a young male. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - May 18, 2020 Category: Pathology Source Type: research

The effect of transversus abdominis plane block on the chronic pain after colorectal surgery: a retrospective cohort study
Chronic postsurgical pain (CPSP) is common and would reduce the quality of life of patients. Transversus abdominal plane (TAP) block has been widely used in lower abdominal surgery and many researches demonstr... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - May 18, 2020 Category: Anesthesiology Authors: Zi-Ye Pan, Zhong-Hua Hu, Fan Zhang, Wen-Xiu Xie, Yong-Zhong Tang and Qin Liao Tags: Research article Source Type: research

Reduced chronic pain: Another benefit of recovery at an inpatient rehabilitation facility over a skilled nursing facility?
Table of Contents Summary: We found that injured patients who were discharged to an IRF were less likely to have chronic pain necessitating medication 6 –12 months post-injury as compared to a matched cohort of patients discharged to a SNF. Interestingly, at least at the time point assessed, there were no differences between groups with regards to functional outcomes and SF-12 physical and mental composite scores. (Source: American Journal of Surgery)
Source: American Journal of Surgery - May 18, 2020 Category: Surgery Authors: Juan P. Herrera-Escobar, David Blake, Alexander Toppo, Kelsey Han, George Kasotakis, Haytham MA. Kaafarani, George Velmahos, Adil H. Haider, Ali Salim, Deepika Nehra Source Type: research

Efficacy of occlusal splints in the treatment of temporomandibular disorders: a systematic review of randomized controlled trials.
Conclusions: An occlusal splint can be considered as a non-invasive treatment approach for patients with TMD, especially those with signs and symptoms of restriction of mandibular movement and pain. Moreover, the present findings highlighted an urgent need of a standardised consensus regarding the prognostic evaluation of TMD. PMID: 32421379 [PubMed - as supplied by publisher] (Source: Acta Odontologica Scandinavica)
Source: Acta Odontologica Scandinavica - May 18, 2020 Category: Dentistry Authors: Zhang SH, He KX, Lin CJ, Liu XD, Wu L, Chen J, Rausch-Fan X Tags: Acta Odontol Scand Source Type: research

Reliability, responsiveness and minimal clinically important difference of the two Fear Avoidance and Beliefs Questionnaire scales in Italian subjects with chronic low back pain undergoing multidisciplinary rehabilitation.
CONCLUSIONS: After triangulation of the above results, a change of 4 points for FABQ-PA and 7 points for FABQ-W were selected as MCID. These two values represent cutoffs that seem to accurately identify meaningful change in fear-avoidance beliefs, according to subject's judgement. CLINICAL REHABILITATION IMPACT: The present study calculated - in a sample of people with chronic Low Back Pain - the minimal clinically important change of the two FABQ scales (FABQ-Physical Activity scale and FABQ-Work scale). These values increase confidence in interpreting score changes, thus enhancing their meaningful use in both resear...
Source: European Journal of Physical and Rehabilitation Medicine - May 18, 2020 Category: Rehabilitation Authors: Monticone M, Frigau L, Vernon H, Rocca B, Giordano A, Vullo SS, Mola F, Franchignoni F Tags: Eur J Phys Rehabil Med Source Type: research

Platelet-rich plasma for treatment of chronic proximal hamstring tendinopathy.
Abstract Aim: To determine whether platelet-rich plasma (PRP) can successfully treat symptoms associated with proximal hamstring tendinopathy. Materials & methods: Charts were retrospectively reviewed of patients with a diagnosis of chronic proximal hamstring tendinopathy who underwent an ultrasound-guided leukocyte-rich PRP injection to assess reported outcomes at baseline and final follow-up post-intervention. Results: In 22 patients with a mean age of 48.7 years and mean symptom duration of 26.5 months, mean Numeric Pain Rating Scale and Victorian Institute of Sport Assessment Scale for Proximal H...
Source: Regenerative Medicine - May 18, 2020 Category: Genetics & Stem Cells Authors: Auriemma MJ, Tenforde AS, Harris A, McInnis KC Tags: Regen Med Source Type: research

Exposure to a motor vehicle collision and the risk of future back pain: A systematic review and meta-analysis.
CONCLUSIONS: There was a consistent positive association in the critically reviewed literature that investigated the risk of future LBP following an acute MVC-related injury. For the patient with chronic low back pain who was initially injured in a MVC, more often than not (63 % of the time) the condition was caused by the MVC. These findings are likely to be of interest to clinicians, insurers, patients, governments and the courts. Future studies from both general and clinical populations would help strengthen these results. PMID: 32438092 [PubMed - as supplied by publisher] (Source: Accident; Analysis and Prevention.)
Source: Accident; Analysis and Prevention. - May 18, 2020 Category: Accident Prevention Authors: Nolet PS, Emary PC, Kristman VL, Murnaghan K, Zeegers MP, Freeman MD Tags: Accid Anal Prev Source Type: research

Central IRAK-4 kinase inhibition for the treatment of pain following nerve injury in rats.
Abstract There is ample evidence for the role of the immune system in developing chronic pain following peripheral nerve injury. Especially Toll-like receptors (TLRs) and their associated signaling components and pro-inflammatory cytokines such as IL-1β, induced after injury, are involved in nociceptive processes and believed to contribute to the manifestation of chronic neuropathic pain states. Whereas the inhibition of the kinase function of IRAK-4, a central kinase downstream of TLRs and IL-1 receptors (IL-1Rs), seems efficacious in various chronic inflammatory and autoimmune models, it's role in regulatin...
Source: Brain, Behavior, and Immunity - May 18, 2020 Category: Neurology Authors: Pletinckx K, Krings D, Welbers A, Rider DA, Dunkern TR Tags: Brain Behav Immun Source Type: research

Omega-3 derivatives, specialized pro-resolving mediators: promising therapeutic tools for the treatment of pain in chronic liver disease
Publication date: Available online 17 May 2020Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): TA Mariqueo, J. Zúñiga-Hernández (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - May 17, 2020 Category: Lipidology Source Type: research

Experience in the Management of Patients with Chronic Vascular Ulcers of the Lower Limbs Using Negatively Charged Polystyrene Microspheres.
Authors: Teresa Cacua Sánchez M Abstract Background: Chronic ulcers of the lower limbs are a socioeconomic health problem, having a high incidence in the adult population. Despite a correct etiological treatment, in addition to the multiple lesion management options available, healing percentage and speed remain low, which makes it a great therapeutic challenge. Objective: To describe the outcome and effectiveness of the use of PolyHeal® Micro in the granulation and epithelialization of chronic ulcers of the lower limbs. Methods: Descriptive observational case series of 19 patients with diagnosis...
Source: International Journal of Vascular Medicine - May 17, 2020 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Satisfactory function 12 years after triscaphoid arthrodesis for chronic scapholunate ligament injury.
Authors: Reigstad O, Grimsgaard C, Holm-Glad T, Korslund J, Thorkildsen RD, Røkkum M Abstract Scapholunate ligament (SLL) injury represents a hazard to the wrist and the treatment of these injuries has been the focus of much debate. We performed a long-term follow (>10 years) of triscaphoid arthrodesis for symptomatic chronic SLL injuries in 10 (8 men) patients 37 (22-49) years of age. All arthrodesis healed. One patient was converted to total wrist arthrodesis during the follow-up period, and three had minor additional surgeries. At final follow-up, the patients had reduced active range of motion ...
Source: Journal of Plastic Surgery and Hand Surgery - May 17, 2020 Category: Surgery Tags: J Plast Surg Hand Surg Source Type: research

Physician Attitudes and Perceptions of Complementary and Alternative Medicine (CAM): A Multicentre Italian Study.
, Danova M, Rossetti S, Amore A, Crispo A, Facchini G Abstract Purpose: Complementary and Alternative Medicine (CAM) interventions are widely used by patients with chronic disorders, including cancer, and may interact with cancer treatment. Physicians are often unaware of this, probably due to poor patient-physician communication on CAM. The purpose of this study was to evaluate physicians' knowledge, attitudes and practice patterns regarding CAM in a survey conducted in Italy. Methods: A questionnaire was administered to 438 physicians (11 Italian hospitals) who predominantly treat patients with chronic disease, ...
Source: Pain Physician - May 17, 2020 Category: Anesthesiology Authors: Berretta M, Rinaldi L, Taibi R, Tralongo P, Fulvi A, Montesarchio V, Madeddu G, Magistri P, Bimonte S, Trovò M, Gnagnarella P, Cuomo A, Cascella M, Lleshi A, Nasti G, Facchini S, Fiorica F, Di Francia R, Nunnari G, Pellicanò GF, Guglielmino A, Danova M, Tags: Front Oncol Source Type: research

Modern management of splenomegaly in patients with myelofibrosis
AbstractMyelofibrosis (MF) is a chronic myeloproliferative neoplasm which can lead to massive splenomegaly secondary to extramedullary hematopoiesis. Patients frequently exhibit debilitating symptoms including pain and early satiety, in addition to cellular sequestration causing severe cytopenias. JAK 1/2 inhibitors, such as ruxolitinib and fedratinib, are the mainstay of therapy and produce significant and durable reductions in spleen volume. However, many patients are not eligible for JAK 2 inhibitor therapy or become refractory to treatment over time. Novel therapies are in development that can reduce the degree of sple...
Source: Annals of Hematology - May 17, 2020 Category: Hematology Source Type: research

IJERPH, Vol. 17, Pages 3495: Why People Do Not Attend Health Screenings: Factors That Influence Willingness to Participate in Health Screenings for Chronic Diseases
Conclusions: Our findings demonstrate that health attitudes, sociodemographic factors, and other motivating and preventative factors affect peoples’ willingness to participate in health screenings. The motivating factors and barriers for people to participate in health screening for chronic diseases are very heterogeneous. However, understanding the barriers and motivating factors to health screening would mean that interventions with the purpose of decreasing people’s health risks and reducing deaths and disabilities caused by a chronic illness could be implemented. (Source: International Journ...
Source: International Journal of Environmental Research and Public Health - May 17, 2020 Category: Environmental Health Authors: Chien Chuang Chen Tags: Article Source Type: research

Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study.
In conclusion, 1,2-unsaturated hepatotoxic PA induced cell cycle regulation processes associated with DNA damage response. Similar effects were observed for all hepatotoxic PA. Effects were observed in a dose range inducing no histopathological alterations and no increase in liver enzymes. Therefore, transcriptomics studies identified changes in expression of genes known to be involved in response to genotoxic compounds at PA doses relevant to humans under worst case exposure scenarios. PMID: 32419051 [PubMed - as supplied by publisher] (Source: Archives of Toxicology)
Source: Archives of Toxicology - May 17, 2020 Category: Toxicology Authors: Ebmeyer J, Rasinger JD, Hengstler JG, Schaudien D, Creutzenberg O, Lampen A, Braeuning A, Hessel-Pras S Tags: Arch Toxicol Source Type: research

Clinical management of endometriosis.
Authors: Luna Russo MA, Chalif JN, Falcone T Abstract Endometriosis is a disease of reproductive age women that is commonly characterized by symptoms that often negatively impact quality of life. The clinical management of endometriosis remains highly variable and mostly influenced by geographic location, practice patterns, and breadth of clinician experience. This variability in treatment has inspired a trend towards multidisciplinary and specialized care of patients suffering from this disease. Surgical sampling, followed by histologic confirmation of endometrial-like tissue, remains the standard for the definiti...
Source: Minerva Ginecologica - May 16, 2020 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Evaluation and Treatment of Primary Headaches in Adolescents
Headache is a common episodic and chronic pain syndrome in adolescents. Evaluation of headaches in primary care requires a comprehensive assessment including lifestyle behaviors and physical examination, as well as an understanding of when to pursue appropriate testing. Primary headache disorders seen in adolescents include migraine and tension-type headache. Pharmacologic management for primary headache includes both acute and prophylactic treatment strategies. (Source: Primary Care: Clinics in Office Practice)
Source: Primary Care: Clinics in Office Practice - May 16, 2020 Category: Primary Care Authors: Suzy Mascaro Walter, Christine Banvard-Fox, Courtney Cundiff Source Type: research

Omega-3 derivatives, specialized pro-resolving mediators: promising therapeutic tools for the treatment of pain in chronic liver disease
Chronic liver diseases (CLD) are a worldwide clinical problem, as they are related to high morbidity and mortality. The principal causes include viral, alcoholism, cholestatic, autoimmune and metabolic diseases such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). These CLD can evolve into cirrhosis and hepatocellular carcinoma (HCC) [1]. Patients with CLD showed significant health problems like ascites, spontaneous bacterial peritonitis, hepatic encephalopathy and persistent variceal bleeding concomitant with a decrease in health-related quality of life [1-3]. (Source: Prostaglandins,...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - May 16, 2020 Category: Biomedical Science Authors: TA Mariqueo, J. Z úñiga-Hernández Source Type: research

A systematic review of cross ‐cultural validation of the pain catastrophizing scale
ConclusionsThese results indicate that the total score of the PCS could be compared across each translated version, however, caution is warranted when each subdomain of the PCS is compared between countries. (Source: European Journal of Pain)
Source: European Journal of Pain - May 16, 2020 Category: Anesthesiology Authors: Tatsunori Ikemoto, Kazuhiro Hayashi, Yukiko Shiro, Youn ‐Chang Arai, Anna Marcuzzi, Daniel Costa, Paul Wrigley Tags: REVIEW ARTICLE Source Type: research

The impact of a modified electronic probe tip design on patient perception of discomfort during periodontal probing using standardised probing force. A randomised controlled trial.
This study evaluated pain associated with electronic probing comparing two commercially available probe tip designs using standardised force. MATERIAL & METHODS: Twenty adult patients with slight-moderate chronic periodontitis received periodontal probing using controlled-force electronic probe at 2 visits. In visit 1, a random arch was probed with either a ball-end (0.6mm diameter, 408 kPa; Test) or straight (0.45mm diameter, 726 kPa; Control) probe tip. The opposing arch was then probed using the other probe tip. Discomfort associated with each probing episode was recorded using visual analogue scale (VAS). 7 da...
Source: Journal of Clinical Periodontology - May 16, 2020 Category: Dentistry Authors: Harrison PL, Stuhr S, Shaddox LM Tags: J Clin Periodontol Source Type: research

Efficacy and tolerability of tapentadol for the treatment of chronic low back pain in elderly patients.
Abstract BACKGROUND: Chronic low back pain (CLBP) is a highly prevalent and disabling condition in the elderly, and yet it is undertreated and understudied in this patient population. Tapentadol is a central analgesic with an improved tolerability profile that may be particularly beneficial to the elderly CLBP. METHODS: We performed an observational retrospective study to comparatively assess the efficacy and tolerability of tapentadol in young and elderly patients with severe CLBP. Sixtyfive young patients (
Source: Aging Clinical and Experimental Research - May 16, 2020 Category: Geriatrics Authors: Freo U, Furnari M, Ambrosio F, Navalesi P Tags: Aging Clin Exp Res Source Type: research

Psychosocial Underpinnings of Pain and Sleep Disturbance in Safety-Net Primary Care Patients.
Conclusions: These findings illustrate the interplay of psychosocial factors with chronic pain and sleep disturbance in a sample of low-income, predominantly African-American patients seeking care at a safety-net primary care clinic. The findings support integrated primary care as a way to target not only behavioral health issues but also the psychosocial factors entangled with physical health. PMID: 32399128 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - May 15, 2020 Category: Anesthesiology Authors: Griffin S, Tan J, Perrin PB, Williams AB, Smith ER, Rybarczyk B Tags: Pain Res Manag Source Type: research

Effects of Rhythmic Sensory Stimulation on Ehlers-Danlos Syndrome: A Pilot Study.
Abstract Ehlers-Danlos syndrome (EDS) is a connective tissue disorder characterized by joint hypermobility and skin extensibility and is often accompanied by chronic pain. Rhythmic sensory stimulation (RSS) can be defined as the stimulation of the senses in a periodic manner within a range of low frequencies. Music plus sound delivered through a vibroacoustic device is a form of RSS and has demonstrated utility in managing pain. In this current study, we conducted an open-label pilot study of 15 patients with hypermobile EDS using RSS as the intervention. Posttreatment improvements were seen in 11 of the 15 patien...
Source: Pain Research and Management - May 15, 2020 Category: Anesthesiology Authors: Vuong V, Mosabbir A, Paneduro D, Picard L, Faghfoury H, Evans M, Gordon A, Bartel L Tags: Pain Res Manag Source Type: research

The Impact of Cognitive Anxiety and the Rating of Pain on Care Processes in a Vigilance Task: The Important Part Played by Age.
This study's aim is therefore to analyse the impact of emotional variables (anxiety and depression), the rating of pain, and age on vigilance processes in a sample of patients with chronic pain. To do so, the attentional performance of a cohort of 52 patients with chronic pain was measured through the use of a modified dot-probe task. Furthermore, all the participants were evaluated using the following self-report measures: Beck's Depression Inventory-II (BDI-II), the McGill Pain Questionnaire, and the Pain Anxiety Symptoms Scale-20 (PASS-20). Stepwise multiple linear regression analysis revealed a significant negative cor...
Source: Pain Research and Management - May 15, 2020 Category: Anesthesiology Authors: Pinel L, Perez-Nieto MA, Redondo M, Rodríguez-Rodríguez L, Mateos LL Tags: Pain Res Manag Source Type: research

Managing chronic pain patients at the time of COVID-19 pandemic.
Authors: Coluzzi F, Marinangeli F, Pergolizzi J PMID: 32400999 [PubMed - as supplied by publisher] (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - May 15, 2020 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Health-related quality of life (Nottingham Health Profile) in patients with endometriomas: correlation with clinical variables and self-reported limitations.
Authors: Chmaj-Wierzchowska K, Rzymski P, Wojciechowska M, Parda I, Wilczak M Abstract Introduction: Endometriosis is a chronic disease that involves the development of endometrium outside the uterine cavity with pain component predominance. The aim of the study was to discuss the occurrence of health problems in patients with endometriomas and simple cysts and the effect of these problems on the daily functioning of the patients. Material and methods: The study included patients (n = 40) treated laparoscopically and/or by laparotomy due to lesions in the form of endometriomas or simple cysts. The control group...
Source: Archives of Medical Science - May 15, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Tips for Understanding the Pathways of Pain & Choosing Treatments
SNOWMASS VILLAGE, COLO.—The science underlying the neurobiology of chronic pain isn’t something rheumatologists often think about. However, pain is an important reason why patients see a rheumatologist. At the 2020 ACR Winter Symposium in January, Leslie Crofford, MD, gave two presentations addressing pain experienced by rheumatology patients, including a session on the fundamental mechanisms of... [Read More] (Source: The Rheumatologist)
Source: The Rheumatologist - May 15, 2020 Category: Rheumatology Authors: Carina Stanton Tags: Analgesics Conditions Pain Management pain mechanisms pain pathways Winter Rheumatology Summit Source Type: research

Mechanisms and mode of action of spinal cord stimulation in chronic neuropathic pain.
Authors: Heijmans L, Joosten EA Abstract Tonic spinal cord stimulation (SCS) has been used as a treatment for chronic neuropathic pain ever since its discovery late 1960's. Despite its clinical successes in a subset of chronic neuropathic pain syndromes, several limitations such as insufficient pain relief and uncomfortable paresthesias, have led to the development of new targets, the dorsal root ganglion, and new stimulation waveforms, such as burst and high frequency. The aim of this review is to provide a brief overview of the main mechanisms behind the mode of action of the different SCS paradigms. Tonic SCS ma...
Source: Postgraduate Medicine - May 15, 2020 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Chronic pain and use of analgesics in the elderly: a nationwide population-based study.
Conclusions: This study delineated the causes of chronic pain and use of analgesics in a geriatric population, which may help further studies about this issue in the future. PMID: 32399112 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Mucosal Tuft Cell Density Is Increased in Diarrhea-Predominant Irritable Bowel Syndrome Colonic Biopsies
Tuft cells are rare chemosensory sentinels found in the gut epithelium. When triggered by helminth infection, tuft cells secrete interleukin-25 (IL-25) basolaterally and subsequently evoke an immune response. Irritable bowel syndrome (IBS) is a common and heterogeneous disorder characterized by bowel dysfunction and visceral pain sensitivity. Dysfunctional gut-brain communication and immune activation contribute to the pathophysiology of this disorder. The study aims were to investigate changes in tuft cell density in non-post-infectious IBS patients. Immunofluorescent labeling of DCLK1-positive tuft cells was carried out ...
Source: Frontiers in Psychiatry - May 15, 2020 Category: Psychiatry Source Type: research