Predictors of Depression, Anxiety and Stress Indicators in a Cohort of Women with Chronic Pelvic Pain [Corrigendum]
(Source: Journal of Pain Research)
Source: Journal of Pain Research - March 26, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

“First do no harm”: why don't we measure adverse events routinely in psychological treatment trials for people with chronic pain?
No abstract available (Source: Pain)
Source: Pain - March 26, 2020 Category: Anesthesiology Tags: Commentary Source Type: research

Are weather conditions associated with chronic musculoskeletal pain? Review of results and methodologies
Many people believe that weather influences chronic musculoskeletal pain. Previous studies on this association are narratively reviewed, with particular focus on comparing methodologies and summarising study findings in light of study quality. We searched 5 databases (Medline, Embase, Web of Science, PsycINFO, and Scopus) for observational studies on the association between weather variables and self-reported musculoskeletal pain severity. Of 4707 located articles, 43 were eligible for inclusion. The majority (67%) found some association between pain and a weather variable. Temperature, atmospheric pressure, relative humid...
Source: Pain - March 26, 2020 Category: Anesthesiology Tags: Narrative Review Source Type: research

Regular dosing compared with as-needed dosing of opioids for management of chronic cancer pain: systematic review and meta-analysis
Opioids are the recommended form of analgesia for patients with persistent cancer pain, and regular dosing “by the clock” is advocated in many international guidelines on cancer pain management. The development of sustained-release opioid preparations has made regular dosing easier for patients. However, patients report that the intensity and impact of their cancer pain varies considerably day to day, and many try to find a trade-off between acceptable pain control and impact of cognitive (and other) adverse effects on daily activities. In acute care settings, (eg, postoperative) as-needed dosing and other opio...
Source: Pain - March 26, 2020 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

Measuring and reporting adverse events in clinical trials of psychological treatments for chronic pain
No abstract available (Source: Pain)
Source: Pain - March 26, 2020 Category: Anesthesiology Tags: Topical Review Source Type: research

New procedure of high-frequency repetitive transcranial magnetic stimulation for central neuropathic pain: a placebo-controlled randomized crossover study
Repetitive transcranial magnetic stimulation (rTMS) is a procedure increasingly used to treat patients with central neuropathic pain, but its efficacy is still under debate. Patients with medically refractory chronic central neuropathic pain were included in 2 randomized phases (active/sham), separated by a wash-out period of 8 weeks. Each phase consisted of 4 consecutive rTMS sessions and a final evaluation session, all separated from one another by 3 weeks. High-frequency (20 Hz) rTMS was delivered over the primary motor cortex (M1) contralateral to the patient's pain using a neuronavigated robotic system. Patients and c...
Source: Pain - March 26, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Hub disruption in patients with chronic neck pain: a graph analytical approach
Chronic pain is known to alter the brain's network dynamics. These dynamics are often demonstrated by identifying alterations in the brain network topology. A common approach used for this purpose is graph theory. To date, little is known on how these potentially altered networks in chronic pain relate to the symptoms reported by these patients. Here, we applied a graph theoretical approach to identify network changes in patients suffering from chronic neck pain, a group that is often neglected in chronic pain research. Participants with chronic traumatic and nontraumatic neck pain were compared to healthy pain-free contro...
Source: Pain - March 26, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Complex regional pain syndrome patient immunoglobulin M has pronociceptive effects in the skin and spinal cord of tibia fracture mice
It has been proposed that complex regional pain syndrome (CRPS) is a post-traumatic autoimmune disease. Previously, we observed that B cells are required for the full expression of CRPS-like changes in a mouse tibia fracture model and that serum immunoglobulin M (IgM) antibodies from fracture mice have pronociceptive effects in muMT fracture mice lacking B cells. The current study evaluated the pronociceptive effects of injecting CRPS patient serum or antibodies into muMT fracture mice by measuring hind paw allodynia and unweighting changes. Complex regional pain syndrome serum binding was measured against autoantigens pre...
Source: Pain - March 26, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Sleep disturbance underlies the co-occurrence of trauma and pediatric chronic pain: a longitudinal examination
Epidemiological and cross-sectional studies have shown that post-traumatic stress disorder symptoms (PTSS) are common and impairing in youth with chronic pain. Yet, the co-occurrence of PTSS and pediatric chronic pain has not been examined longitudinally, which has limited understanding of theoretically proposed mechanisms (eg, sleep disturbance) underlying the PTSS-pain relationship over time. This longitudinal study aimed to fill this gap. Participants included 138 youth (Mage = 14.29, 75% girls) referred to a tertiary-level outpatient chronic pain program and one of their parents. At baseline, youth reported their pain ...
Source: Pain - March 26, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Cell-specific exon methylation and CTCF binding in neurons regulates calcium ion channel splicing and function
Cell-specific alternative splicing modulates myriad cell functions and is disrupted in disease. The mechanisms governing alternative splicing are known for relatively few genes and typically focus on RNA splicing factors. In sensory neurons, cell-specific alternative splicing of the presynaptic CaV channelCacna1b gene modulates opioid sensitivity. How this splicing is regulated is unknown. We find that cell and exon -specific DNA hypomethylation permits CTCF binding, the master regulator of mammalian chromatin structure, which, in turn, controls splicing in a DRG-derived cell line.In vivo, hypomethylation of an alternative...
Source: eLife - March 26, 2020 Category: Biomedical Science Tags: Cell Biology Neuroscience Source Type: research

Effect of Dextrose Prolotherapy on Pain Intensity, Disability, and Plantar Fascia Thickness in Unilateral Plantar Fasciitis: A Randomized, Controlled, Double-Blind Study
Objective The aim of the study was to evaluate the efficacy of dextrose prolotherapy in the treatment of chronic resistant plantar fasciitis through comparison with a control group. Design In this double-blind, randomized, controlled study, the patients were divided into two groups. The prolotherapy group (n = 30) was administered 5 ml of 30% dextrose, 4 ml of saline, and 1 ml of 2% lidocaine mixture (15% dextrose solution) and the control group was given 9 ml of saline and 1 ml of 2% lidocaine mixture twice at a 3-wk interval. During the 15-wk follow-up period, pain intensity was measured using the visual analog scal...
Source: American Journal of Physical Medicine and Rehabilitation - March 25, 2020 Category: Rehabilitation Tags: Original Research Articles Source Type: research

Adverse outcomes, polysubstance use, and polypharmacy in older veterans
Older veterans have the highest number of lives lost to suicide, make up majority of the veteran population, and are highly likely to experience conditions (e.g., chronic pain, sleep disorders, musculoskeletal) associated with commonly prescribed medications that are potential markers for suicide risk (hereafter referred to as “high-risk” drug categories), including benzodiazepines, sedative-hypnotics, opioids, antidepressants, antipsychotics, and antiepileptics. The research presented in this session will highlight important patterns in high-risk drug prescribing and use and related outcomes in late life. (Sou...
Source: The American Journal of Geriatric Psychiatry - March 25, 2020 Category: Geriatrics Authors: Amy Byers, Donovan Maust, Ruth Morin, Lisa Barry Tags: Session 114 Source Type: research

Novel interventions for the community care of late-life depression: a report by the weill cornell alacrity center
The research team will present effectiveness data of three developmental projects offering ALACRITY treatments to primary care patients living with depression and chronic pain, depressed mistreatment victims, and depressed attendees of senior centers. Dr. Alexopoulos will present neurobiological findings that contributed to the neurobiological model of mid- and late-life depression and discuss the rationale for developing this model and highlight how they can be used to streamline behavioral interventions. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - March 25, 2020 Category: Geriatrics Authors: George Alexopoulos, Patricia Marino, Dimitris Kiosses, Jo Anne Sirey Tags: Session 113 Source Type: research

Cerebrospinal fluid of chronic osteoarthritic patients induced interleukin-6 release in human glial cell-line T98G
Chronic osteoarthritic pain is not well understood in terms of its pathophysiological mechanism. Activated glial cells are thought to play a role in the maintenance of chronic pain. T98G glioblastoma cell line... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - March 25, 2020 Category: Anesthesiology Authors: Weiling Liu, Chunmei Li, Francis Chee Kuan Tan, Hong Jye Neo, Yiong Huak Chan, Chian-Ming Low and Tat Leang Lee Tags: Research article Source Type: research

Optimum imaging of chronic pancreatitis
AbstractChronic pancreatitis is an inflammatory process of the pancreas characterized by progressive parenchyma destruction, resulting in pain and exocrine and endocrine insufficiency. In the advanced stages the diagnosis by imaging is usually straightforward, while in the early phases of the disease there can be a paucity of findings at imaging, thus making an early diagnosis challenging. Different imaging modalities can have a role in the initial diagnosis and in the longitudinal follow-up of patients affected by chronic pancreatitis, also enabling to assess the complications of the disease. Radiography, Ultrasonography,...
Source: Abdominal Imaging - March 25, 2020 Category: Radiology Source Type: research

Andrographolide sulfonate ameliorates chronic colitis induced by TNBS in mice via decreasing inflammation and fibrosis.
Abstract Inflammatory bowel disease could result in diarrhea and abdominal pain, as well as potential complications such as tissue fibrosis. The therapeutic effect of andrographolide sulfonate on acute murine experimental colitis induced by 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) has been confirmed. In the study here, chronic colitis triggered by repeated intrarectal administration of TNBS was established and the effect of andrographolide sulfonate was examined. Repeated TNBS administration induced substantial mice death, which was significantly decreased by andrographolide sulfonate treatment. The elevation ...
Source: International Immunopharmacology - March 25, 2020 Category: Allergy & Immunology Authors: Gao J, Cui J, Zhong H, Li Y, Liu W, Jiao C, Gao J, Jiang C, Guo W, Xu Q Tags: Int Immunopharmacol Source Type: research

Recurrent Pancreatitis in Children: Past, Present, and Future
Recurrent acute and chronic pancreatitis are increasingly recognized in childhood. Etiologies are vastly different in children compared with adults and mostly involve genetic and anatomical factors with negligible contribution of environmental risks. Pediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) have significant impact on quality of life with high healthcare costs. Children with these conditions suffer from recurrent acute or chronic abdominal pain and they endure multiple emergency room visits, hospitalizations, procedures, and surgeries. Diagnostic methods are being developed; treatment optio...
Source: Journal of Pediatric Gastroenterology and Nutrition - March 24, 2020 Category: Gastroenterology Tags: Topic of the Month Source Type: research

Opioid-induced immunosuppression and carcinogenesis promotion theories create the newest trend in acute and chronic pain pharmacotherapy
Opioids are the main group of pharmacological agents used during the perioperative period and provide a sedative and analgesic component. The observations of opioid consumption in West Europe indicate that this group of drugs is widely used in chronic noncancer pain therapy. Nearly 20 years ago, the first publications indicating that opioids, as an element of perioperative pharmacotherapy in oncologic patients, increase the risk of tumor recurrence and affect further prognosis were presented. The actual publications suggest that there are multifactorial, complex mechanisms underlying the immunological impact and carcinogen...
Source: Clinics - March 24, 2020 Category: General Medicine Source Type: research

A Renal Impairment Subgroup Analysis of the Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving Opioid Therapy
(Source: Journal of Pain Research)
Source: Journal of Pain Research - March 24, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Clindamycin inhibits nociceptive response by reducing tumor necrosis factor- α and CXCL-1 production and activating opioidergic mechanisms
AbstractClindamycin, a bacteriostatic semisynthetic lincosamide, is useful in the management of infections caused by aerobic and anaerobic Gram-positive cocci, including bacteremic pneumonia, streptococcal toxic shock syndrome and sepsis. It has been recently demonstrated that clindamycin inhibits in vitro and in vivo inflammatory cytokine production. In the present study, we investigated the effects of clindamycin in acute and chronic models of pain and inflammation in mice and the underlying mechanisms. Intraperitoneal (i.p.) administration of clindamycin (400  mg/kg) increased the animal’s latency to exhibit ...
Source: Inflammopharmacology - March 24, 2020 Category: Drugs & Pharmacology Source Type: research

Transcriptomic analysis of long noncoding RNAs and mRNAs expression profiles in the spinal cord of bone cancer pain rats
Bone cancer pain (BCP) is one of the most common types of chronic cancer pain and its pathogenesis has not been fully understood. Long non-coding RNAs (lncRNAs) are new promising targets in the field of pain r... (Source: Molecular Brain)
Source: Molecular Brain - March 24, 2020 Category: Neuroscience Authors: Xinran Hou, Yingqi Weng, Qulian Guo, Zhuofeng Ding, Jian Wang, Jiajia Dai, Anqi Wei and Zongbin Song Tags: Research Source Type: research

New Resource for Managing Patients Receiving Long-term Opioid Therapy
The Agency for Healthcare Research and Quality (AHRQ) recently updated a toolkit for primary care practices who treat patients with chronic pain who take opioids. As AHRQ noted, most patients taking opioids for chronic pain are managed by primary care practitioners and their staffs. (Source: JAMA)
Source: JAMA - March 24, 2020 Category: General Medicine Source Type: research

Urolithin a attenuates IL-1 β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes
Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation and is one of the most common chronic degenerative joint diseases that causes pain and disability in adults. Urol... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 24, 2020 Category: Allergy & Immunology Authors: Sheng-long Ding, Zhi-ying Pang, Xue-mei Chen, Zheng Li, Xin-xin Liu, Qi-lin Zhai, Jun-ming Huang and Zhi-yong Ruan Tags: Research Source Type: research

Sex Differences Linking Pain-Related Fear and Interoceptive Hypervigilance: Attentional Biases to Conditioned Threat and Safety Signals in a Visceral Pain Model
Although the broad role of fear and hypervigilance in conditions of the gut-brain axis like irritable bowel syndrome is supported by converging evidence, the underlying mechanisms remain incompletely understood. Even in healthy individuals, it remains unclear how pain-related fear may contribute to pain-related attentional biases for acute visceral pain. Building on our classical fear conditioning work in a clinically relevant model of visceral pain, we herein elucidated pain-related attentional biases shaped by associative learning in healthy women and men, aiming to elucidate possible sex differences and the role of psyc...
Source: Frontiers in Psychiatry - March 24, 2020 Category: Psychiatry Source Type: research

Exercise for the intervertebral disc: a 6-month randomised controlled trial in chronic low back pain
ConclusionsThis trial found that 6  months of exercise did not benefit the IVD of people with NSCLBP. Based on this index study, future studies could investigate the effect of exercise on IVD in different populations, with different types, durations and/or intensities of exercise, and using different IVD markers.Graphic abstractThese slides can be retrieved under Electronic Supplementary Material. (Source: European Spine Journal)
Source: European Spine Journal - March 24, 2020 Category: Orthopaedics Source Type: research

Chronic pain after lung resection: risk factors, neuropathic pain, and quality of life
Chronic post-surgical pain (CPSP) can occur frequently after thoracic surgery. This retrospective study aimed to determine CPSP prevalence, risk factors, neuropathic pain (NP) occurrence and its impact on quality of life. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - March 24, 2020 Category: Palliative Care Authors: Silvia Fiorelli, Luigi Cioffi, Cecilia Menna, Mohsen Ibrahim, Roberto Alberto De Blasi, Erino Angelo Rendina, Monica Rocco, Domenico Massullo Tags: Original Article Source Type: research

Viral Vector –Mediated Gene Transfer of Glutamic Acid Decarboxylase for Chronic Pain Treatment: A Literature Review
Human Gene Therapy, Ahead of Print. (Source: Human Gene Therapy)
Source: Human Gene Therapy - March 24, 2020 Category: Genetics & Stem Cells Authors: Megumi Kanao-Kanda Hirotsugu Kanda Shue Liu Sabita Roy Michal Toborek Shuanglin Hao Source Type: research

Buprenorphine: prospective novel therapy for depression and PTSD.
CONCLUSIONS: Pharmaceuticals' abilities to treat medical conditions directly relates to their ability to act upon the endogenous biological systems related to the conditions. Thus, these recent findings are likely a reflection of the central role that the endogenous opioid system has in these mental illnesses. Further studies are necessary to study the involvement of endogenous opioid systems, and specifically KOR, in mediating buprenorphine's beneficial effects and the ability to treat these medical conditions while minimizing risks for misuse and diversion. PMID: 32204739 [PubMed - as supplied by publisher] (Source:...
Source: Psychological Medicine - March 24, 2020 Category: Psychiatry Authors: Madison CA, Eitan S Tags: Psychol Med Source Type: research

[Superficial circumflex iliac artery perforator free flap in pediatric reconstruction: A case report].
We report the case of a thirteen year-old child who presented a third-degree burn sequelae on the dorsalis pedis with scar retraction and chronic ulceration on the fifth metatarsal despite multiple skin grafts. He couldn't put on his shoes because of the pain and walking was difficult. We performed a SCIP flap (Superficial Circumflex Iliac Artery Perforator) to reconstruct this defect. The flap measuring 12×7cm has been harvested on the right groin and anastomosed with the pedicle of the first intermetatarsal space. At 3 months postoperatively, the child can put on his shoes again and walk without pain. The donor sit...
Source: Annales de Chirurgie Plastique et Esthetique - March 24, 2020 Category: Cosmetic Surgery Authors: Tawa P, Lévy J, Brault N, Madar Y, Qassemyar Q Tags: Ann Chir Plast Esthet Source Type: research

Stress and Self-Efficacy as Long-Term Predictors for Chronic Low Back Pain: A Prospective Longitudinal Study
(Source: Journal of Pain Research)
Source: Journal of Pain Research - March 23, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Novel Intermittent Dosing Burst Paradigm in Spinal Cord Stimulation
IntroductionIntermittent dosing (ID), in which periods of stimulation ‐on are alternated with periods of stimulation‐off, is generally employed using 30 sec ON and 90 sec OFF intervals with burst spinal cord stimulation (SCS). The goal of this study was to evaluate the feasibility of using extended stimulation‐off periods in patients with chronic intractable pain.Materials and MethodsThis prospective, multicenter, feasibility trial evaluated the clinical efficacy of the following ID stimulation ‐off times: 90, 120, 150, and 360 sec with burst waveform parameters. After a successful trial (≥5...
Source: Neuromodulation: Technology at the Neural Interface - March 23, 2020 Category: Biotechnology Authors: Timothy R. Deer, Denis G. Patterson, Javid Baksh, Jason E. Pope, Pankaj Mehta, Adil Raza, Filippo Agnesi, Krishnan V. Chakravarthy Tags: Clinical Research Source Type: research

Efficacy of dry needling as an adjunct to manual therapy for patients with chronic mechanical neck pain: a randomised clinical trial.
This study found that between-group differences in pain intensity were statistically significant (P
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - March 23, 2020 Category: Complementary Medicine Authors: Gallego-Sendarrubias GM, Rodríguez-Sanz D, Calvo-Lobo C, Martín JL Tags: Acupunct Med Source Type: research

Sphenopalatine Ganglion Pulsed Radiofrequency for the Treatment of Refractory Chronic SUNCT and SUNA: A Prospective Case Series.
CONCLUSIONS: In our small series of patients with refractory chronic SUNCT/SUNA, SPG-PRF was a safe and effective treatment modality. The potential reproducible positive effect of subsequent treatments may prevent or delay the use of more invasive and costly interventions for at least a proportion of these patients. PMID: 32202666 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - March 23, 2020 Category: Neurology Authors: Ornello R, Palmisani S, Murphy M, Sacco S, Al-Kaisy A, Lambru G Tags: Headache Source Type: research

10-kHz High-Frequency Spinal Cord Stimulation for Adults With Chronic Noncancer Pain: A Health Technology Assessment.
Conclusions: For adults with chronic noncancer pain that was refractory to medical management, 10-kHz high-frequency SCS was effective in relieving pain, reducing disability, and improving quality of life. Because there was limited evidence about the effectiveness of 10-kHz high-frequency SCS in people who had first tried and failed SCS at lower frequencies (up to 1.2 kHz), we were unable to determine whether 10-kHz high-frequency SCS is cost-effective in the Ontario context. We estimate that publicly funding 10-kHz high-frequency SCS in Ontario would result in cost savings of about $0.10 million to $0.21 million per year,...
Source: Ontario Health Technology Assessment Series - March 22, 2020 Category: General Medicine Tags: Ont Health Technol Assess Ser Source Type: research

Opioid Use and Appropriateness of Supply After Total Knee or Hip Arthroplasty: An Australian Perspective.
DISCUSSION: More than half of the patients undergoing total knee arthroplasty or total hip arthroplasty were still using opioids at 3 weeks postdischarge. Most patients were not supplied with excessive quantities at discharge. Future research should focus on identifying patients at risk of prolonged opioid use and improving the transition of these patients into the community. LEVEL OF EVIDENCE: Level II-Prognostic study = prospective observational study. PMID: 32195829 [PubMed - as supplied by publisher] (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - March 22, 2020 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

Exploring unmet healthcare needs, healthcare access, and the use of Practitioner Based Complementary and Alternative Medicine in adults with Chronic Pain.
Authors: LaChance J, Booth R, Befus D Abstract BACKGROUND: Chronic pain is a complex condition frequently encountered in nursing practice. Estimated to affect 21% of Canadian adults, chronic pain results in negative multidimensional effects on the individual and healthcare system. Increasingly, people with chronic pain are turning to Complementary and Alternative Medicine to manage their pain. Unmet healthcare needs can motivate Complementary and Alternative Medicine use, directly related to healthcare access. OBJECTIVES: The purpose of this study was to explore the relationship between healthcare access, unmet...
Source: Contemporary Nurse - March 22, 2020 Category: Nursing Tags: Contemp Nurse Source Type: research

Efficacy and safety of a novel hydrogel (HYADD4-G) in degenerative disc disease patients: a multicentric open label study.
Authors: Mazza E, Marcia S, Mondaini F, Piras E, Giordan N, Torri T, Barbanti-Bròdano G, Parodi F Abstract OBJECTIVE: In this premarket clinical study, we evaluated the efficacy and safety of a novel Hydrogel (HYADD4-G) for reducing low back pain (LBP) in patients with degenerative disc disease (DDD). PATIENTS AND METHODS: Twenty-three patients with chronic LBP were enrolled. All patients presented with up to three lumbar black discs (Pfirrmann grade III or IV), LBP of at least 40 mm on the Visual Analogue Scale (VAS), and a Roland-Morris Disability Questionnaire (RMDQ) score of at least 9. Patients rece...
Source: European Review for Medical and Pharmacological Sciences - March 21, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

No flare(s), no problem: treating recalcitrant pancreatic duct strictures with short fully covered metal stents
Pain, the hallmark symptom of chronic pancreatitis, remains difficult to treat, particularly given the unclear mechanism of pain in this disease.1 Pain likely results from an interplay between pancreatic ductal and parenchymal hypertension in combination with neural remodeling and sensitization, making it particularly challenging to identify which patients will respond to which treatments.2 (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - March 21, 2020 Category: Gastroenterology Authors: Samuel Han, Raj J. Shah Tags: Original article Source Type: research

‘I’m not too bad with needles’: a qualitative service evaluation of chronic pain patients’ experiences of self-acupuncture
Publication date: Available online 19 March 2020Source: European Journal of Integrative MedicineAuthor(s): John G Hughes, Catrina Davy (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - March 21, 2020 Category: Complementary Medicine Source Type: research

Fertility Outcomes After Laparoscopic Cystectomy in Infertile Patients with Stage  III–IV Endometriosis: a Cohort with 6–10 years of Follow-up
AbstractIntroductionOvarian endometriosis is the most common type of endometriosis (EM), affecting more than 40% of women with EM. Currently, surgical intervention is still controversial in infertile patients with ovarian endometriosis, especially in those with stage  III–IV EM. Very few studies have been done to analyze long-term pregnancy results in patients with endometrioma more than 5 years after surgery. Therefore, the aim of this study was to explore the pregnancy outcomes and the related factors in patients with endometrioma and stage III–IV endom etriosis during a long-term follow-up pos...
Source: Advances in Therapy - March 21, 2020 Category: Drugs & Pharmacology Source Type: research

A Comprehensive Review of the Treatment and Management of Pain in Sickle Cell Disease
AbstractPurpose of ReviewSickle cell disease (SCD) is a hematological disorder which leads to serious complications in multiple organ systems. While significant research has addressed many of the effects of acute pain episodes and end-organ damage connected to this disease, little has approached the chronic pain state associated with this condition.Recent FindingsAssociated chronic pain represents a significant detractor from the quality of life experienced by these patients, affecting over half of those with SCD on more days than not. Current treatment typically is centered upon preventing and responding to acute vasooccl...
Source: Current Pain and Headache Reports - March 21, 2020 Category: Neurology Source Type: research

A Comprehensive Review of Over-the-counter Treatment for Chronic Migraine Headaches
AbstractPurpose of ReviewMigraine headaches are a neurologic disorder characterized by attacks of moderate to severe throbbing headache that are typically unilateral, exacerbated by physical activity, and associated with phonophobia, photophobia, nausea, and vomiting. In the USA, the overall age-adjusted prevalence of migraine in female and male adults is 22.3% and 10.8%, respectively.Recent FindingsMigraine is a disabling disease that ranks as the 8th most burdensome disease in the world and the 4th most in women. The overarching hypothesis of migraine pathophysiology describes migraine as a disorder of the pain modulatin...
Source: Current Pain and Headache Reports - March 21, 2020 Category: Neurology Source Type: research

Temporal tendinosis: A cause of chronic orofacial pain
AbstractPurpose of ReviewDiverse musculoskeletal disorders and neuropathic symptoms of the face pose significant diagnostic challenges. In particular, temporal tendinosis is generally overlooked in the medical and dental literature and is therefore a poorly understood topic and often problematic cause of chronic orofacial pain. In this article, we explore temporal tendinosis as a cause of unresolved orofacial pain by reviewing the complex anatomy of the temporalis muscle, common presentations of temporal tendinosis, possible etiologies for injury and place a strong emphasis on required diagnostic evaluation and clinical ma...
Source: Current Pain and Headache Reports - March 21, 2020 Category: Neurology Source Type: research

Beliefs about chronic low back pain amongst osteopaths registered in Spain: A cross-sectional survey
Healthcare providers' attitudes and beliefs might influence patients ’ attitudes and beliefs as well as their management approach. It was hypothesised that osteopaths have a more biopsychosocial mindset towards chronic low back pain (CLBP) because of their holistic reasoning. (Source: International Journal of Osteopathic Medicine)
Source: International Journal of Osteopathic Medicine - March 21, 2020 Category: Complementary Medicine Authors: Tom Van Biesen, Gerard Alvarez Tags: Original Article Source Type: research

An Exploratory Proton MRS Examination of Gamma-Aminobutyric Acid, Glutamate, and Glutamine and Their Relationship to Affective Aspects of Chronic Pain
Publication date: Available online 19 March 2020Source: Neuroscience ResearchAuthor(s): Margaret D. Legarreta, Chandni Sheth, Andrew P. Prescot, Perry F. Renshaw, Erin C. McGlade, Deborah A. Yurgelun-Todd (Source: Neuroscience Research)
Source: Neuroscience Research - March 20, 2020 Category: Neuroscience Source Type: research

Chronic low back pain
(Source: Skeletal Radiology)
Source: Skeletal Radiology - March 20, 2020 Category: Radiology Source Type: research

Electroacupuncture Inhibits the Activity of Astrocytes in Spinal Cord in Rats with Visceral Hypersensitivity by Inhibiting P2Y1 Receptor-Mediated MAPK/ERK Signaling Pathway.
Conclusion: EA inhibited astrocyte activity in the spinal cord dorsal horn of rat with IBS visceral hypersensitivity by inhibiting the P2Y1 receptor and its downstream, PKC, and MAPK/ERK1/2 pathways. PMID: 32184891 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - March 20, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effectiveness of an Eye-Cervical Re-Education Program in Chronic Neck Pain: A Randomized Clinical Trial.
Conclusions: The Eye-Cervical Re-education Program is effective at relieving pain pressure thresholds in the upper trapezius, right levator scapula, and left splenius capitis and especially effective for increasing the cervical range of motion. This trial is registered with NCT03197285 (retrospective registration). PMID: 32184889 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - March 20, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

[Bio-Psycho-Social Therapy for Stress-Induced Chronic Pain].
Abstract Bio-Psycho-Social Therapy for Stress-Induced Chronic Pain Abstract. Against the background of latest neurobiological and epigenetic findings the bio-psycho-social model of disease is outlined often misinterpreted in the context of chronic pain. It represents the basic principle for a personalized treatment of stress-induced chronic pain. Consequences for diagnostic procedures are delineated to detect this pathogenetic subgroup of chronic pain patients (e.g. fibromyalgia, back pain, temporomandibular dysfunction, tension headache). Finally, the principles of a bio-psycho-social treatment program with high ...
Source: Praxis - March 20, 2020 Category: General Medicine Authors: Egle UT, Seeher C, Cattapan K Tags: Praxis (Bern 1994) Source Type: research