Adverse events of nucleos(t)ide analogues for chronic hepatitis B: a systematic review
In conclusion, treatment of CHB with NAs is safe, with a low incidence of AEs. Despite the general understanding TAF being safer than TDF, the number of patients treated with TAF still is too small in comparison to other NAs to consolidate an accurate safety profile. PROSPERO Registration No. CRD42018086471 (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 17, 2020 Category: Gastroenterology Source Type: research

Mapping evidence on the prevalence, incidence, risk factors and cost associated with chronic low back pain among adults in Sub-Saharan Africa: a systematic scoping review protocol
DiscussionThe study anticipates finding relevant literature on the prevalence, incidence, risk factors, mortality, and cost associated with CLBP among adults in SSA. The study outcomes will aid in identifying research gaps, planning, informing policy, commissioning of future research, and funding prioritization. (Source: Systematic Reviews)
Source: Systematic Reviews - March 17, 2020 Category: International Medicine & Public Health Source Type: research

Osteopathic Treatment leads to significantly greater reductions in chronic thoracic pain after CABG surgery: a randomised controlled trial
There are a number of long-term postoperative complications after coronary artery bypass graft (CABG) surgery. Pulmonary function is decreased by 12% and 30% to 50% of the patients have chronic thoracic pain. (Source: Journal of Bodywork and Movement Therapies)
Source: Journal of Bodywork and Movement Therapies - March 17, 2020 Category: Physiotherapy Authors: Gert Roncada Tags: Prevention and Rehabilitation Source Type: research

Behavioural disturbance after intravenous ketamine infusion for treatment of refractory chronic pain
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - March 17, 2020 Category: Anesthesiology Source Type: research

Managing Pain and Psychosocial Care in IBD: a Primer for the Practicing Gastroenterologist
AbstractPurpose of ReviewThis review focuses on the relationship between trauma and pain in inflammatory bowel disease (IBD), and offers effective treatment strategies.Recent FindingsRecent evidence points to bidirectional pathways between psychiatric disorders and IBD. The impact of trauma and development of post-traumatic stress symptoms on IBD disease course is beginning to be appreciated including its relationship with pain. First-line treatments for both psychiatric and chronic pain disorders include behavioral interventions such as cognitive behavioral therapy, hypnosis, and mindfulness, and there is emerging evidenc...
Source: Current Gastroenterology Reports - March 17, 2020 Category: Gastroenterology Source Type: research

Cannabinoids Improve Gastrointestinal Symptoms in a Parenteral Nutrition-Dependent Patient With Chronic Intestinal Pseudo-Obstruction.
We report a case of successful use of medicinal cannabinoids in a patient with CIPO, resulting in a significant reduction of abdominal pain, vomiting, and subocclusive episodes and increased appetite and weight, without major adverse events. Although further observations are required to consolidate these findings, this case may be helpful for other patients suffering from the same condition. PMID: 32181915 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - March 17, 2020 Category: Nutrition Authors: Zemrani B, Lambe C, Goulet O Tags: JPEN J Parenter Enteral Nutr Source Type: research

Behavioural disturbance after intravenous ketamine infusion for treatment of refractory chronic pain.
PMID: 32185629 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 17, 2020 Category: Anesthesiology Authors: Pushparaj H, Bhatia A Tags: Can J Anaesth Source Type: research

The locus coeruleus noradrenergic system gates deficits in visual attention induced by chronic pain.
Abstract Despite years of research on pain comorbidity with affective disorders and cognitive deficits, it is still unclear how deficit in attention co-occurs with chronic pain. It is likely that altered neuroplasticity and or dysregulated neurotransmitters induced by chronic pain, at which pain and cognitive processing systems overlap, may have a negative effect on cognitive processing such as attention. One of the main common networks involved in attentional and pain processing is the noradrenergic system originating from the locus coeruleus (LC). We hypothesized that heightened noradrenaline release from LC ind...
Source: Behavioural Brain Research - March 17, 2020 Category: Neurology Authors: Moazen P, Torabi M, Azizi H, Fathollahi Y, Mirnajafi-Zadeh J, Semnanian S Tags: Behav Brain Res Source Type: research

Comparison of Paresthesia Mapping to Anatomical Placement in Burst Spinal Cord Stimulation: Initial Trial Results of the Prospective, Multicenter, Randomized, Double ‐Blinded, Crossover, CRISP Study
DiscussionThe trial results of this study suggest that similar clinical outcomes can be achieved in burst SCS when performing lead placement either using paresthesia mapping or anatomical placement with imaging references. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - March 16, 2020 Category: Biotechnology Authors: Adnan Al ‐Kaisy, Ganesan Baranidharan, Stefano Palmisani, David Pang, Onita Will, Samuel Wesley, Tracey Crowther, Karl Ward, Paul Castino, Adil Raza, Filippo Agnesi Tags: Clinical Research Source Type: research

Too old for a paediatric emergency department? It ’s complex
ConclusionThis is the first Irish study demonstrating a significant population (>  15 years) with medical complexity that requires a suite of services in a paediatric hospital which is accessed in an unscheduled manner through an emergency department. We recommend further research to describe paediatric CCC attending Irish emergency and hospital services. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 16, 2020 Category: General Medicine Source Type: research

Modulation of Pain Sensitivity by Chronic Consumption of Highly Palatable Food Followed by Abstinence: Emerging Role of Fatty Acid Amide Hydrolase
In this study, we investigated whether long-term exposure to a CAF diet could modify pain sensitivity and explored the role of the cannabinergic system in this modification. Male Sprague–Dawley rats were divided into two groups: one fed with standard chow only (CO) and the other with extended access (EA) to a CAF diet. Hot plate and tail flick tests were used to evaluate pain sensitivity. At the end of a 40-day CAF exposure, EA rats showed a significant increase in the pain threshold compared to CO rats, finding probably due to up-regulation of CB1 and mu-opioid receptors. Instead, during abstinence from palatable fo...
Source: Frontiers in Pharmacology - March 16, 2020 Category: Drugs & Pharmacology Source Type: research

Headache Perception in an Epilepsy Patient with Neuromodulation by Anterior Thalamic Nuclei Deep Brain Stimulation: A Case Report
Conclusion ANT-DBS and VNS may influence epilepsy-associated chronic headache in different ways. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part A: Central European Neurosurgery)
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - March 16, 2020 Category: Neurosurgery Authors: Pintea, Bogdan Surges, Rainer Bostr öm, Jan Tags: Case Report Source Type: research

Management of Chronic Back Pain in the Elderly
No abstract available (Source: Contemporary Spine Surgery)
Source: Contemporary Spine Surgery - March 15, 2020 Category: Orthopaedics Tags: ARTICLE Source Type: research

Minocycline reduces experimental muscle hyperalgesia induced by repeated nerve growth factor injections in humans: A placebo ‐controlled double‐blind drug‐crossover study
ConclusionsThis study indicates that the administration of minocycline can reduce experimentally induced muscle pain regardless of the time of administration. (Source: European Journal of Pain)
Source: European Journal of Pain - March 15, 2020 Category: Anesthesiology Authors: James.S. Dunn, Saad.S. Nagi, David.A Mahns Tags: ORIGINAL ARTICLE Source Type: research

Anodal transcranial direct current stimulation over the primary motor cortex attenuates capsaicin ‐induced dynamic mechanical allodynia and mechanical pain sensitivity in humans
AbstractBackgroundAnodal transcranial direct current stimulation over the primary cortex has been shown to activate regions of the brain involved in the descending modulation of pain sensitivity. However, more research is required in order to dissect the spinal cord analgesic mechanisms associated with the development of central sensitisation.MethodsIn this randomised, double blind, cross over study 12 healthy participants had baseline mechanical stimulus response (S/R) functions measured before and after the development of capsaicin ‐induced ongoing pain sensitivity. The effects of 20 min of either real or sham tra...
Source: European Journal of Pain - March 15, 2020 Category: Anesthesiology Authors: SW Hughes, G Ward, PH. Strutton Tags: ORIGINAL ARTICLE Source Type: research

Amygdala, neuropeptides, and chronic pain-related affective behaviors.
Abstract Neuropeptides play important modulatory roles throughout the nervous system, functioning as direct effectors or as interacting partners with other neuropeptide and neurotransmitter systems. Limbic brain areas involved in learning, memory and emotions are particularly rich in neuropeptides. This review will focus on the amygdala, a limbic region that plays a key role in emotional-affective behaviors and pain modulation. The amygdala is comprised of different nuclei; the basolateral (BLA) and central (CeA) nuclei and in between, the intercalated cells (ITC), have been linked to pain-related functions. A wid...
Source: Neuropharmacology - March 15, 2020 Category: Drugs & Pharmacology Authors: Neugebauer V, Mazzitelli M, Cragg B, Ji G, Navratilova E, Porreca F Tags: Neuropharmacology Source Type: research

Abnormal alpha band power in the dynamic pain connectome is a marker of chronic pain with a neuropathic component
Publication date: Available online 13 March 2020Source: NeuroImage: ClinicalAuthor(s): Lee B. Kisler, Junseok A. Kim, Kasey S. Hemington, Anton Rogachov, Joshua C. Cheng, Rachael L. Bosma, Natalie R. Osborne, Benjamin T. Dunkley, Robert D. Inman, Karen D. Davis (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - March 14, 2020 Category: Radiology Source Type: research

Session 114
Older veterans have the highest number of lives lost to suicide, make up majority of the veteran population, and are highly likely to experience conditions (e.g., chronic pain, sleep disorders, musculoskeletal) associated with commonly prescribed medications that are potential markers for suicide risk (hereafter referred to as “high-risk” drug categories), including benzodiazepines, sedative-hypnotics, opioids, antidepressants, antipsychotics, and antiepileptics. The research presented in this session will highlight important patterns in high-risk drug prescribing and use and related outcomes in late life. (Sou...
Source: The American Journal of Geriatric Psychiatry - March 14, 2020 Category: Geriatrics Authors: Amy Byers, Donovan Maust, Ruth Morin, Lisa Barry Tags: ADVERSE OUTCOMES, POLYSUBSTANCE USE, AND POLYPHARMACY IN OLDER VETERANS Source Type: research

Session 113
The research team will present effectiveness data of three developmental projects offering ALACRITY treatments to primary care patients living with depression and chronic pain, depressed mistreatment victims, and depressed attendees of senior centers. Dr. Alexopoulos will present neurobiological findings that contributed to the neurobiological model of mid- and late-life depression and discuss the rationale for developing this model and highlight how they can be used to streamline behavioral interventions. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - March 14, 2020 Category: Geriatrics Authors: George Alexopoulos, Patricia Marino, Dimitris Kiosses, Jo Anne Sirey Tags: NOVEL INTERVENTIONS FOR THE COMMUNITY CARE OF LATE-LIFE DEPRESSION: A REPORT BY THE WEILL CORNELL ALACRITY CENTER Source Type: research

Impact of pain interference on treatment outcomes among older adults with depressive and anxiety symptoms receiving collaborative mental health care
Depression, anxiety and chronic pain are highly comorbid in the elderly population. These symptoms can interfere with daily activities and adversely affect quality of life. The mechanisms underlying the associations among pain and mental health symptoms are complex and likely bidirectional in nature. This interrelatedness between pain, depression and anxiety symptoms can often lead to diagnostic uncertainty and polypharmacy. Moreover, the literature points to less favorable outcomes among those receiving treatment for depression and anxiety who report comorbid pain. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - March 14, 2020 Category: Geriatrics Authors: Senthil Vel Rajan Rajaram Manoharan, Senthil Vel Rajan Rajaram Manoharan, Arushi Kapoor, Shahrzad Mavandadi, Joel E. Streim Tags: Poster Number: EI-32 Source Type: research

Peripherally acting opioid analgesics and peripherally-induced analgesia
The management of pain, particularly chronic pain, is still an area of medical need. In this context, opioids remain a gold standard for the treatment of pain. However, significant side effects, mainly of central origin, limit their clinical use. Here, we review recent progress to improve the therapeutic and safety profiles of opioids for pain management. Characterization of peripheral opioid-mediated pain mechanisms have been a key component of this process. Several studies identified peripheral µ, δ, and κ opioid receptors (MOR, DOR, and KOR, respectively) and nociceptin/orphanin FQ (NOP) receptors as s...
Source: Behavioural Pharmacology - March 14, 2020 Category: Drugs & Pharmacology Tags: Review Articles Source Type: research

Effects of oxycodone and diazepam alone and in combination on operant nociception
Developing effective analgesics with fewer unwanted side effects is a pressing concern. Due to a lack of effective nonopioid options currently available, an alternative approach termed opioid-sparing evaluates the ability of a coadministered drug to reduce the amount of opioid needed to produce an antinociceptive effect. Opioids and benzodiazepines are often coprescribed. Although this approach is theoretically rational given the prevalent comorbidity of chronic pain and anxiety, it also has inherent risks of respiratory depression, which is likely responsible for the substantial percentage of fatal opioid overdoses that h...
Source: Behavioural Pharmacology - March 14, 2020 Category: Drugs & Pharmacology Tags: Short Reports Source Type: research

Pannexin ‐1 in the CNS: emerging concepts in health and disease
AbstractPannexin ‐1 (Panx1) is a large pore membrane channel with unique conduction properties ranging from non‐selective ion permeability to the extracellular release of signalling molecules. The release of ATP by Panx1 has been particularly well‐characterized with implications in purine signalling across a v ariety of biological contexts. Panx1 activity is also important in inflammasome formation and the secretion of pro‐inflammatory molecules such as interleukin‐1β. Within the central nervous system (CNS), Panx1 is expressed on both neurons and glia, and is thought to mediate crosstalk between the se cell...
Source: Journal of Neurochemistry - March 14, 2020 Category: Neuroscience Authors: Albert K. Yeung, Chetan S. Patil, Michael F. Jackson Tags: REVIEW ARTICLE Source Type: research

Patient-reported pain and other symptoms among breast cancer survivors: prevalence and risk factors.
Authors: Divella M, Vetrugno L, Bertozzi S, Seriau L, Carla C, Bove T Abstract OBJECTIVE: To investigate the prevalence and risk factors associated with chronic pain and other symptoms related to breast cancer 6 months after surgery. METHODS: In an observational study of 261 female breast cancer survivors treated between January 2017 and January 2018, patients were asked about their pain symptoms using a questionnaire that utilized the Numeric Rating Score (NRS) and the Douleur Neuropathique Score (DN4) for neuropathic pain; it also addressed phantom sensations and functional disorders on the ipsilateral should...
Source: Tumori - March 14, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Diffuse large B-cell lymphoma involving the left sternoclavicular joint mimicking rheumatoid arthritis flare: a case-based review
We report the case of a 65-year-old man with RA suffering from pain and swelling of left sternoclavicular (SC) joint, which was not relieved by adding low-dose glucocorticoid. Magnetic resonance imaging (MRI) showed a para-osseous soft tissue swelling around the SC joint and a fracture of proximal clavicle. Histology of the soft tissue demonstrated diffuse large B-cell lymphoma and the patient subsequently underwent R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy. He was successfully treated with six cycles of R-CHOP chemotherapy, with discontinuation of MTX, resulting in a com...
Source: Rheumatology International - March 14, 2020 Category: Rheumatology Source Type: research

Pain-related fear in adolescents with chronic musculoskeletal pain: process evaluation of an interdisciplinary graded exposure program
For studying the effectiveness of treatment, it is important to check whether a new treatment is performed as originally described in the study-protocol. (Source: BMC Health Services Research)
Source: BMC Health Services Research - March 14, 2020 Category: General Medicine Authors: C. Dekker, J. C. M. van Haastregt, J. A. M. C. F. Verbunt, J. R. de Jong, T. van Meulenbroek, H. F. M. Pernot, A. D. van Velzen, C. H. G. Bastiaenen and M. E. J. B. Goossens Tags: Research article Source Type: research

Different kinds of acupuncture treatments for knee osteoarthritis: a multicentre, randomized controlled trial
Knee osteoarthritis (KOA) is a chronic disease with symptoms of persistent pain or resting pain, joint stiffness, numbness, limitation of activity and even disability, with significant associated costs and eff... (Source: Trials)
Source: Trials - March 14, 2020 Category: General Medicine Authors: Qifei Zhang, Jianqiao Fang, Lifang Chen, Jiayao Wu, Jing Ni, Fang Liu and Jing Sun Tags: Study protocol Source Type: research

Transcranial direct current stimulation improves quality of life and physical fitness in diabetic polyneuropathy: a pilot double blind randomized controlled trial
ConclusionsIt is suggested that five sessions of anodal M1 tDCS improves QoL and functionality of patients with diabetic polyneuropathy. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - March 14, 2020 Category: Endocrinology Source Type: research

Inhibitory effect of amenamevir on acute herpetic pain and postherpetic neuralgia in mice infected with herpes simplex virus-1
Herpes zoster is a viral skin disease caused by reactivation of latent varicella-zoster virus (VZV) in sensory ganglia [1]. Its characteristic symptom is a unilateral dermatomal vesicular rash, usually accompanied by acute herpetic pain (AHP) [2,3]. In some patients, the pain does not resolve when the vesicular rash heals, but continues for weeks and sometimes months or years; this chronic pain is termed “postherpetic neuralgia (PHN),” a debilitating condition that can be very difficult to manage, especially in the elderly in whom herpes zoster tends to be more severe [4,5]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 14, 2020 Category: Dermatology Authors: Yuhki Ueda, Daisuke Uta, Soichiro Tanbo, Akiko Kawabata, Shoji Kanayama, Miho Osaki, Naoki Nozawa, Tatsumi Matsumoto, Tsugunobu Andoh Source Type: research

Analgesic Effects of Cannabinoids for Chronic Non-cancer Pain: a Systematic Review and Meta-Analysis with Meta-Regression
AbstractThere is growing interest in using cannabinoids for chronic pain. We performed a systematic review and meta-analysis of randomized controlled trials to evaluate the analgesic efficacy and adverse effects of cannabinoids for chronic non-cancer pain. PubMed, EMBASE, Web of Science, Cochrane CENTRAL andclinicaltrials.gov were searched up to December 2018. Information on the type, dosage, route of administration, pain conditions, pain scores, and adverse events were extracted for qualitative analysis. Meta-analysis of analgesic efficacy was performed. Meta-regression was performed to compare the analgesic efficacy for ...
Source: Journal of NeuroImmune Pharmacology - March 14, 2020 Category: Drugs & Pharmacology Source Type: research

Psychological Stress-Induced Immune Response and Risk of Alzheimer's Disease in Veterans from Operation Enduring Freedom and Operation Iraqi Freedom.
Abstract PURPOSE: Psychological stress is a significant health problem in veterans and their family members. Traumatic brain injury (TBI) and stress lead to the onset, progression, and worsening of several inflammatory and neurodegenerative diseases in veterans and civilians. Alzheimer's disease (AD) is a progressive, irreversible neuroinflammatory disease that causes problems with memory, thinking, and behavior. TBIs and chronic psychological stress cause and accelerate the pathology of neuroinflammatory diseases such as AD. However, the precise molecular and cellular mechanisms governing neuroinflammation and ne...
Source: Clinical Therapeutics - March 14, 2020 Category: Drugs & Pharmacology Authors: Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Raikwar SP, Zaheer SA, Iyer SS, Burton C, James D, Zaheer A Tags: Clin Ther Source Type: research

Role of Glia in the Regulation of Sleep in Health and Disease.
Authors: Garofalo S, Picard K, Limatola C, Nadjar A, Pascual O, Tremblay MÈ Abstract Sleep is a naturally occurring physiological state that is required to sustain physical and mental health. Traditionally viewed as strictly regulated by top-down control mechanisms, sleep is now known to also originate locally. Glial cells are emerging as important contributors to the regulation of sleep-wake cycles, locally and among dedicated neural circuits. A few pioneering studies revealed that astrocytes and microglia may influence sleep pressure, duration as well as intensity, but the precise involvement of these two ...
Source: Comprehensive Physiology - March 13, 2020 Category: Physiology Tags: Compr Physiol Source Type: research

Higher leisure-time physical activity is associated with lower sickness absence: cross-sectional analysis among the general workforce.
CONCLUSIONS: The results suggest that higher LTPA is associated with lower SA in a particular category of workers, that might benefit from physical activity strategies. PMID: 32162505 [PubMed - as supplied by publisher] (Source: Journal of Sports Medicine and Physical Fitness)
Source: Journal of Sports Medicine and Physical Fitness - March 13, 2020 Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research

The Impact of Preoperative Chronic Opioid Therapy in Patients Undergoing Decompression Laminectomy of the Lumbar Spine
Conclusion. Patients on chronic opioids prior to spine surgery are more likely to have a longer hospital stay and continue on opioids for a longer time after surgery, compared with patients not on chronic opioid therapy. Spine surgeons and pain specialists should seek to identify patients on chronic opioids before surgery and evaluate strategies to optimize pain management in the pre- and postoperative course. Level of Evidence: 3 (Source: Spine)
Source: Spine - March 13, 2020 Category: Orthopaedics Tags: CLINICAL CASE SERIES Source Type: research

The Association Between Patient-reported Clinical Factors and 30-day Acute Care Utilization in Chronic Heart Failure
Conclusions: Patient-reported poor health status, pain, and poor appetite were positively associated with 30-day acute care utilization. These novel postdischarge markers require further study before incorporation into risk prediction to drive quality improvement efforts. (Source: Medical Care)
Source: Medical Care - March 13, 2020 Category: Health Management Tags: Original Articles Source Type: research

Stringent Control of Opioids: Sound Public Health Measures, but a Step Too Far in Palliative Care?
AbstractPurpose of ReviewOpioids are the only class of drug with the proven ability to control severe pain. The introduction of stringent opioid prescribing restrictions has inevitably impacted upon the ability of those prescribing opioids for advanced life-limited disease to practice as previously and could limit the supply of adequate pain relief to patients with cancer. This review considers the evidence that symptom management of patients with advanced cancer contributes to the “opioid problem” and whether there is adequate recognition of the risks involved.Recent FindingsThe literature suggests that the ri...
Source: Current Oncology Reports - March 13, 2020 Category: Cancer & Oncology Source Type: research

Buprenorphine in the Treatment of Chronic Pain
This article reviews the pharmacology and clinical effectiveness of buprenorphine in the context of chronic pain treatment. (Source: Physical Medicine and Rehabilitation Clinics of North America)
Source: Physical Medicine and Rehabilitation Clinics of North America - March 13, 2020 Category: Rehabilitation Authors: Gregory D. Rudolf Source Type: research

Muscle Relaxants for Acute and Chronic Pain
This article provides an overview of the different types muscles relaxants and their adverse effects. Appropriate medication selection based on clinical indications is also examined. (Source: Physical Medicine and Rehabilitation Clinics of North America)
Source: Physical Medicine and Rehabilitation Clinics of North America - March 13, 2020 Category: Rehabilitation Authors: Wilson J. Chang Source Type: research

Persistent chikungunya arthritis in Roraima, Brazil
AbstractBackgroundThe Amazon region of Brazil experienced a large epidemic of East Central South African (ECSA) chikungunya virus (CHIKV) in 2017 and continuous transmission of CHIKV persists. The impact of chronic arthritis caused by ECSA CHIKV is unknown.ObjectiveThe study aim was to describe the duration, severity, and characteristics of CHIKV arthritis in Roraima, Brazil, in comparison with local controls to further understand the long-term rheumatologic impact of ECSA CHIKV infection.MethodsWe performed a cross-sectional analysis comparing clinical arthritis outcomes among 40 cases with chronic (>  3 mo...
Source: Clinical Rheumatology - March 13, 2020 Category: Rheumatology Source Type: research

The role of the cannabinoid system in opioid analgesia and tolerance.
Abstract Opioid receptor agonist drugs, such as morphine, are very effective for treating chronic and severe pain; but, tolerance can develop with long-term use. Although there is a lot of information about the pathophysiological mechanisms of opioid tolerance, it is still not fully clarified. Suggested mechanisms for opioid tolerance include opioid receptor desensitisation, reduction of sensitivity G-proteins, activation of mitogen-activated protein kinase (MAPK), altered intracellular signaling pathway including nitric oxide, and activation of mammalian target of rapamycin (mTOR). One way to reduce opioid tolera...
Source: Mini Reviews in Medicinal Chemistry - March 13, 2020 Category: Chemistry Authors: Ozdemir E Tags: Mini Rev Med Chem Source Type: research

Novel analgesic agents obtained by molecular hybridization of orthosteric and allosteric ligands.
Abstract Despite the high incidence of acute and chronic pain in the general population, the efficacy of currently available medications is unsatisfactory. Insufficient management of pain has a profound impact on the quality of life and can have serious physical, psychological, social, and economic consequences. This unmet need reflects a failure to develop novel classes of analgesic drugs with superior clinical properties and lower risk of abuse. Nevertheless, recent advances in our understanding of the neurobiology of pain are offering new opportunities for developing different therapeutic approaches. Among thos...
Source: European Journal of Pharmacology - March 13, 2020 Category: Drugs & Pharmacology Authors: Matera C, Flammini L, Riefolo F, Domenichini G, De Amici M, Barocelli E, Dallanoce C, Bertoni S Tags: Eur J Pharmacol Source Type: research

Use of oipiods for chronic non-cancer pain. Reply.
Authors: Fuster D, Muga R PMID: 32156427 [PubMed - as supplied by publisher] (Source: Medicina Clinica)
Source: Medicina Clinica - March 12, 2020 Category: General Medicine Tags: Med Clin (Barc) Source Type: research

Prescribing opioids to patients with chronic pain: translation of the opioid rsk tool into Italian.
Authors: Miceli L, Bednarova R, Cuomo A, Cascella M, Guardamagna V, Romualdi P, Marinangeli F PMID: 32154683 [PubMed - as supplied by publisher] (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - March 12, 2020 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Characterization of Pain Symptomatology in Head and Neck Cancer (HNC) Survivors
We present prospective data characterizing HNC related pain from baseline through 12 months post treatment including diverse pain syndromes such as painful mouth ulcers, dental sensitivity, mucosal sensitivity (peripheral sensitization), and widespread pain (central sensitization). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 12, 2020 Category: Radiology Authors: D. Lou, M. Dietrich, J. Deng, B. Murphy Tags: Toxicity, Quality of Life, Survivorship, Costs of Care Source Type: research

Risk of suicidal self-directed violence among survivors of head and neck cancer: A retrospective cohort analysis
Head and neck cancer survivors (HNCS) suffer from high rates of chronic pain, substance use, and mental health comorbidities. HNCS have one of the highest rates of suicide among patients with cancer and are almost twice as likely to die by suicide compared to other cancer survivors. Among a national cohort of Veteran HNCS, we examined the associations between chronic pain, mental health and substance use disorder (SUD) diagnoses, and engagement in mental health services with risk of suicidal self-directed violence (SSDV), which included both suicide attempts and death by suicide. (Source: International Journal of Radiation...
Source: International Journal of Radiation Oncology * Biology * Physics - March 12, 2020 Category: Radiology Authors: S.M. Nugent, L. Ganzini, R. Handley, E. Hooker, J. Chen, B. Morasco, D. Sullivan, C.G. Slatore Tags: K. Kian Ang, MD, PhD, FASTRO, Commemorative Plenary Session Source Type: research

4CInfluence of Neighborhood Disorder on Perceived Control Over Pain and Pain-Related Function in African Americans
The purpose of these studies was to determine the influence of neighborhood disorder on pain-related function as mediated by perceived control over pain in urban residing African Americans. Neighborhood disorder is characterized by physical and social features of a neighborhood that may signal the breakdown of order and social control, and may include high poverty, increased crime, poor building condition, housing instability, and low educational levels of residents. Current knowledge in chronic pain research is extended by addressing gaps linking neighborhood disorder and perceived control over pain as a mediator to pain-...
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Angelika Maly Source Type: research

3DManaging Chronic Pain the ED
Pain remains one of the primary complaints that causes patients to seek care in the emergency department. Overall, there has been a significant increase in the number of patients who present to the emergency department with a pain complaint. Pain can be either acute or chronic. Patients express many reasons why they choose to come to the emergency department for care related to their pain. Reasons include lack of funds to consult a pain management specialist; work hours which do not allow them to be seen by a primary care provider; trying to deal with the pain on their own and being encouraged or told to use the ED for car...
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Renee Holleran Source Type: research

3CMultimodal Analgesia Tried and True and Those Less Used
Opioid use in acute and chronic persistent pain continues as epidemic levels. Although for many, opioids provide reasonable pain relief, dose escalation is one of many contributions to dangerous respiratory suppression, opioid dependence and opioid hyperalgesia. The aim of this presentation is to discuss and review medications used in multimodal analgesia and its opioid sparing effect. In lecture format, a number of medications will be reviewed. These medications include but are not limited to Topical agents, Gabapentinoids, Antidepressants, over the counter medications, Ketamine and Buprenorphine. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Michelle M. Lavelle-Henry Source Type: research

2DSpinal Cord Stimulation: Is It for My Patient?
The aim of this investigation was to review the available types of spinal cord stimulation used in the management of chronic pain, to identify the appropriate criteria for patient selection, and to outline the typical protocol for spinal cord stimulation trial and implantation. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Megan Filoramo Source Type: research