Urolithin a attenuates IL-1 β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes
Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation and is one of the most common chronic degenerative joint diseases that causes pain and disability in adults. Urol... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 24, 2020 Category: Allergy & Immunology Authors: Sheng-long Ding, Zhi-ying Pang, Xue-mei Chen, Zheng Li, Xin-xin Liu, Qi-lin Zhai, Jun-ming Huang and Zhi-yong Ruan Tags: Research Source Type: research

Sex Differences Linking Pain-Related Fear and Interoceptive Hypervigilance: Attentional Biases to Conditioned Threat and Safety Signals in a Visceral Pain Model
Although the broad role of fear and hypervigilance in conditions of the gut-brain axis like irritable bowel syndrome is supported by converging evidence, the underlying mechanisms remain incompletely understood. Even in healthy individuals, it remains unclear how pain-related fear may contribute to pain-related attentional biases for acute visceral pain. Building on our classical fear conditioning work in a clinically relevant model of visceral pain, we herein elucidated pain-related attentional biases shaped by associative learning in healthy women and men, aiming to elucidate possible sex differences and the role of psyc...
Source: Frontiers in Psychiatry - March 24, 2020 Category: Psychiatry Source Type: research

Exercise for the intervertebral disc: a 6-month randomised controlled trial in chronic low back pain
ConclusionsThis trial found that 6  months of exercise did not benefit the IVD of people with NSCLBP. Based on this index study, future studies could investigate the effect of exercise on IVD in different populations, with different types, durations and/or intensities of exercise, and using different IVD markers.Graphic abstractThese slides can be retrieved under Electronic Supplementary Material. (Source: European Spine Journal)
Source: European Spine Journal - March 24, 2020 Category: Orthopaedics Source Type: research

Chronic pain after lung resection: risk factors, neuropathic pain, and quality of life
Chronic post-surgical pain (CPSP) can occur frequently after thoracic surgery. This retrospective study aimed to determine CPSP prevalence, risk factors, neuropathic pain (NP) occurrence and its impact on quality of life. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - March 24, 2020 Category: Palliative Care Authors: Silvia Fiorelli, Luigi Cioffi, Cecilia Menna, Mohsen Ibrahim, Roberto Alberto De Blasi, Erino Angelo Rendina, Monica Rocco, Domenico Massullo Tags: Original Article Source Type: research

Viral Vector –Mediated Gene Transfer of Glutamic Acid Decarboxylase for Chronic Pain Treatment: A Literature Review
Human Gene Therapy, Ahead of Print. (Source: Human Gene Therapy)
Source: Human Gene Therapy - March 24, 2020 Category: Genetics & Stem Cells Authors: Megumi Kanao-Kanda Hirotsugu Kanda Shue Liu Sabita Roy Michal Toborek Shuanglin Hao Source Type: research

Buprenorphine: prospective novel therapy for depression and PTSD.
CONCLUSIONS: Pharmaceuticals' abilities to treat medical conditions directly relates to their ability to act upon the endogenous biological systems related to the conditions. Thus, these recent findings are likely a reflection of the central role that the endogenous opioid system has in these mental illnesses. Further studies are necessary to study the involvement of endogenous opioid systems, and specifically KOR, in mediating buprenorphine's beneficial effects and the ability to treat these medical conditions while minimizing risks for misuse and diversion. PMID: 32204739 [PubMed - as supplied by publisher] (Source:...
Source: Psychological Medicine - March 24, 2020 Category: Psychiatry Authors: Madison CA, Eitan S Tags: Psychol Med Source Type: research

[Superficial circumflex iliac artery perforator free flap in pediatric reconstruction: A case report].
We report the case of a thirteen year-old child who presented a third-degree burn sequelae on the dorsalis pedis with scar retraction and chronic ulceration on the fifth metatarsal despite multiple skin grafts. He couldn't put on his shoes because of the pain and walking was difficult. We performed a SCIP flap (Superficial Circumflex Iliac Artery Perforator) to reconstruct this defect. The flap measuring 12×7cm has been harvested on the right groin and anastomosed with the pedicle of the first intermetatarsal space. At 3 months postoperatively, the child can put on his shoes again and walk without pain. The donor sit...
Source: Annales de Chirurgie Plastique et Esthetique - March 24, 2020 Category: Cosmetic Surgery Authors: Tawa P, Lévy J, Brault N, Madar Y, Qassemyar Q Tags: Ann Chir Plast Esthet Source Type: research

Stress and Self-Efficacy as Long-Term Predictors for Chronic Low Back Pain: A Prospective Longitudinal Study
(Source: Journal of Pain Research)
Source: Journal of Pain Research - March 23, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Novel Intermittent Dosing Burst Paradigm in Spinal Cord Stimulation
IntroductionIntermittent dosing (ID), in which periods of stimulation ‐on are alternated with periods of stimulation‐off, is generally employed using 30 sec ON and 90 sec OFF intervals with burst spinal cord stimulation (SCS). The goal of this study was to evaluate the feasibility of using extended stimulation‐off periods in patients with chronic intractable pain.Materials and MethodsThis prospective, multicenter, feasibility trial evaluated the clinical efficacy of the following ID stimulation ‐off times: 90, 120, 150, and 360 sec with burst waveform parameters. After a successful trial (≥5...
Source: Neuromodulation: Technology at the Neural Interface - March 23, 2020 Category: Biotechnology Authors: Timothy R. Deer, Denis G. Patterson, Javid Baksh, Jason E. Pope, Pankaj Mehta, Adil Raza, Filippo Agnesi, Krishnan V. Chakravarthy Tags: Clinical Research Source Type: research

Efficacy of dry needling as an adjunct to manual therapy for patients with chronic mechanical neck pain: a randomised clinical trial.
This study found that between-group differences in pain intensity were statistically significant (P
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - March 23, 2020 Category: Complementary Medicine Authors: Gallego-Sendarrubias GM, Rodríguez-Sanz D, Calvo-Lobo C, Martín JL Tags: Acupunct Med Source Type: research

Sphenopalatine Ganglion Pulsed Radiofrequency for the Treatment of Refractory Chronic SUNCT and SUNA: A Prospective Case Series.
CONCLUSIONS: In our small series of patients with refractory chronic SUNCT/SUNA, SPG-PRF was a safe and effective treatment modality. The potential reproducible positive effect of subsequent treatments may prevent or delay the use of more invasive and costly interventions for at least a proportion of these patients. PMID: 32202666 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - March 23, 2020 Category: Neurology Authors: Ornello R, Palmisani S, Murphy M, Sacco S, Al-Kaisy A, Lambru G Tags: Headache Source Type: research

10-kHz High-Frequency Spinal Cord Stimulation for Adults With Chronic Noncancer Pain: A Health Technology Assessment.
Conclusions: For adults with chronic noncancer pain that was refractory to medical management, 10-kHz high-frequency SCS was effective in relieving pain, reducing disability, and improving quality of life. Because there was limited evidence about the effectiveness of 10-kHz high-frequency SCS in people who had first tried and failed SCS at lower frequencies (up to 1.2 kHz), we were unable to determine whether 10-kHz high-frequency SCS is cost-effective in the Ontario context. We estimate that publicly funding 10-kHz high-frequency SCS in Ontario would result in cost savings of about $0.10 million to $0.21 million per year,...
Source: Ontario Health Technology Assessment Series - March 22, 2020 Category: General Medicine Tags: Ont Health Technol Assess Ser Source Type: research

Opioid Use and Appropriateness of Supply After Total Knee or Hip Arthroplasty: An Australian Perspective.
DISCUSSION: More than half of the patients undergoing total knee arthroplasty or total hip arthroplasty were still using opioids at 3 weeks postdischarge. Most patients were not supplied with excessive quantities at discharge. Future research should focus on identifying patients at risk of prolonged opioid use and improving the transition of these patients into the community. LEVEL OF EVIDENCE: Level II-Prognostic study = prospective observational study. PMID: 32195829 [PubMed - as supplied by publisher] (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - March 22, 2020 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

Exploring unmet healthcare needs, healthcare access, and the use of Practitioner Based Complementary and Alternative Medicine in adults with Chronic Pain.
Authors: LaChance J, Booth R, Befus D Abstract BACKGROUND: Chronic pain is a complex condition frequently encountered in nursing practice. Estimated to affect 21% of Canadian adults, chronic pain results in negative multidimensional effects on the individual and healthcare system. Increasingly, people with chronic pain are turning to Complementary and Alternative Medicine to manage their pain. Unmet healthcare needs can motivate Complementary and Alternative Medicine use, directly related to healthcare access. OBJECTIVES: The purpose of this study was to explore the relationship between healthcare access, unmet...
Source: Contemporary Nurse - March 22, 2020 Category: Nursing Tags: Contemp Nurse Source Type: research

Efficacy and safety of a novel hydrogel (HYADD4-G) in degenerative disc disease patients: a multicentric open label study.
Authors: Mazza E, Marcia S, Mondaini F, Piras E, Giordan N, Torri T, Barbanti-Bròdano G, Parodi F Abstract OBJECTIVE: In this premarket clinical study, we evaluated the efficacy and safety of a novel Hydrogel (HYADD4-G) for reducing low back pain (LBP) in patients with degenerative disc disease (DDD). PATIENTS AND METHODS: Twenty-three patients with chronic LBP were enrolled. All patients presented with up to three lumbar black discs (Pfirrmann grade III or IV), LBP of at least 40 mm on the Visual Analogue Scale (VAS), and a Roland-Morris Disability Questionnaire (RMDQ) score of at least 9. Patients rece...
Source: European Review for Medical and Pharmacological Sciences - March 21, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

No flare(s), no problem: treating recalcitrant pancreatic duct strictures with short fully covered metal stents
Pain, the hallmark symptom of chronic pancreatitis, remains difficult to treat, particularly given the unclear mechanism of pain in this disease.1 Pain likely results from an interplay between pancreatic ductal and parenchymal hypertension in combination with neural remodeling and sensitization, making it particularly challenging to identify which patients will respond to which treatments.2 (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - March 21, 2020 Category: Gastroenterology Authors: Samuel Han, Raj J. Shah Tags: Original article Source Type: research

‘I’m not too bad with needles’: a qualitative service evaluation of chronic pain patients’ experiences of self-acupuncture
Publication date: Available online 19 March 2020Source: European Journal of Integrative MedicineAuthor(s): John G Hughes, Catrina Davy (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - March 21, 2020 Category: Complementary Medicine Source Type: research

Fertility Outcomes After Laparoscopic Cystectomy in Infertile Patients with Stage  III–IV Endometriosis: a Cohort with 6–10 years of Follow-up
AbstractIntroductionOvarian endometriosis is the most common type of endometriosis (EM), affecting more than 40% of women with EM. Currently, surgical intervention is still controversial in infertile patients with ovarian endometriosis, especially in those with stage  III–IV EM. Very few studies have been done to analyze long-term pregnancy results in patients with endometrioma more than 5 years after surgery. Therefore, the aim of this study was to explore the pregnancy outcomes and the related factors in patients with endometrioma and stage III–IV endom etriosis during a long-term follow-up pos...
Source: Advances in Therapy - March 21, 2020 Category: Drugs & Pharmacology Source Type: research

A Comprehensive Review of the Treatment and Management of Pain in Sickle Cell Disease
AbstractPurpose of ReviewSickle cell disease (SCD) is a hematological disorder which leads to serious complications in multiple organ systems. While significant research has addressed many of the effects of acute pain episodes and end-organ damage connected to this disease, little has approached the chronic pain state associated with this condition.Recent FindingsAssociated chronic pain represents a significant detractor from the quality of life experienced by these patients, affecting over half of those with SCD on more days than not. Current treatment typically is centered upon preventing and responding to acute vasooccl...
Source: Current Pain and Headache Reports - March 21, 2020 Category: Neurology Source Type: research

A Comprehensive Review of Over-the-counter Treatment for Chronic Migraine Headaches
AbstractPurpose of ReviewMigraine headaches are a neurologic disorder characterized by attacks of moderate to severe throbbing headache that are typically unilateral, exacerbated by physical activity, and associated with phonophobia, photophobia, nausea, and vomiting. In the USA, the overall age-adjusted prevalence of migraine in female and male adults is 22.3% and 10.8%, respectively.Recent FindingsMigraine is a disabling disease that ranks as the 8th most burdensome disease in the world and the 4th most in women. The overarching hypothesis of migraine pathophysiology describes migraine as a disorder of the pain modulatin...
Source: Current Pain and Headache Reports - March 21, 2020 Category: Neurology Source Type: research

Temporal tendinosis: A cause of chronic orofacial pain
AbstractPurpose of ReviewDiverse musculoskeletal disorders and neuropathic symptoms of the face pose significant diagnostic challenges. In particular, temporal tendinosis is generally overlooked in the medical and dental literature and is therefore a poorly understood topic and often problematic cause of chronic orofacial pain. In this article, we explore temporal tendinosis as a cause of unresolved orofacial pain by reviewing the complex anatomy of the temporalis muscle, common presentations of temporal tendinosis, possible etiologies for injury and place a strong emphasis on required diagnostic evaluation and clinical ma...
Source: Current Pain and Headache Reports - March 21, 2020 Category: Neurology Source Type: research

Beliefs about chronic low back pain amongst osteopaths registered in Spain: A cross-sectional survey
Healthcare providers' attitudes and beliefs might influence patients ’ attitudes and beliefs as well as their management approach. It was hypothesised that osteopaths have a more biopsychosocial mindset towards chronic low back pain (CLBP) because of their holistic reasoning. (Source: International Journal of Osteopathic Medicine)
Source: International Journal of Osteopathic Medicine - March 21, 2020 Category: Complementary Medicine Authors: Tom Van Biesen, Gerard Alvarez Tags: Original Article Source Type: research

An Exploratory Proton MRS Examination of Gamma-Aminobutyric Acid, Glutamate, and Glutamine and Their Relationship to Affective Aspects of Chronic Pain
Publication date: Available online 19 March 2020Source: Neuroscience ResearchAuthor(s): Margaret D. Legarreta, Chandni Sheth, Andrew P. Prescot, Perry F. Renshaw, Erin C. McGlade, Deborah A. Yurgelun-Todd (Source: Neuroscience Research)
Source: Neuroscience Research - March 20, 2020 Category: Neuroscience Source Type: research

Chronic low back pain
(Source: Skeletal Radiology)
Source: Skeletal Radiology - March 20, 2020 Category: Radiology Source Type: research

Electroacupuncture Inhibits the Activity of Astrocytes in Spinal Cord in Rats with Visceral Hypersensitivity by Inhibiting P2Y1 Receptor-Mediated MAPK/ERK Signaling Pathway.
Conclusion: EA inhibited astrocyte activity in the spinal cord dorsal horn of rat with IBS visceral hypersensitivity by inhibiting the P2Y1 receptor and its downstream, PKC, and MAPK/ERK1/2 pathways. PMID: 32184891 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - March 20, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effectiveness of an Eye-Cervical Re-Education Program in Chronic Neck Pain: A Randomized Clinical Trial.
Conclusions: The Eye-Cervical Re-education Program is effective at relieving pain pressure thresholds in the upper trapezius, right levator scapula, and left splenius capitis and especially effective for increasing the cervical range of motion. This trial is registered with NCT03197285 (retrospective registration). PMID: 32184889 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - March 20, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

[Bio-Psycho-Social Therapy for Stress-Induced Chronic Pain].
Abstract Bio-Psycho-Social Therapy for Stress-Induced Chronic Pain Abstract. Against the background of latest neurobiological and epigenetic findings the bio-psycho-social model of disease is outlined often misinterpreted in the context of chronic pain. It represents the basic principle for a personalized treatment of stress-induced chronic pain. Consequences for diagnostic procedures are delineated to detect this pathogenetic subgroup of chronic pain patients (e.g. fibromyalgia, back pain, temporomandibular dysfunction, tension headache). Finally, the principles of a bio-psycho-social treatment program with high ...
Source: Praxis - March 20, 2020 Category: General Medicine Authors: Egle UT, Seeher C, Cattapan K Tags: Praxis (Bern 1994) Source Type: research

C-X-C Motif Chemokine 10 Contributes to the Development of Neuropathic Pain by Increasing the Permeability of the Blood –Spinal Cord Barrier
Neuropathic pain is among the most debilitating forms of chronic pain. Studies have suggested that chronic pain pathogenesis involves neuroimmune interactions and blood–spinal cord barrier (BSCB) disruption. However, the underlying mechanisms are poorly understood. We modeled neuropathic pain in rats by inducing chronic constriction injury (CCI) of the sciatic nerve and analyzed the effects on C-X-C motif chemokine 10 (CXCL10)/CXCR3 activation, BSCB permeability, and immune cell migration from the circulation into the spinal cord. We detected CXCR3 expression in spinal neurons and observed that CCI induced CXCL10/CXC...
Source: Frontiers in Immunology - March 20, 2020 Category: Allergy & Immunology Source Type: research

Challenges in the Provision of End-of-life and Palliative Care to Ethnic Nepali Refugees
After over a decade of resettlement of ethnic Nepali refugees in the United States, a significant population of seriously ill refugees will require palliative care and hospice care. The refugee experience and culturally specific factors affect the end-of-life care of this population. Challenges in the end-of-life care of Nepali refugees include challenges related to social and health inequities such as significant chronic respiratory disease burden, lack of protocols for deferral of illness disclosure, lack of support for group decision making, unfamiliarity with spiritual, religious and traditional health practices and di...
Source: Journal of Pain and Symptom Management - March 20, 2020 Category: Palliative Care Authors: Salim N. Najjar, Fern R. Hauck Tags: Special Article Source Type: research

Child catastrophizing about parent chronic pain: A potential child vulnerability factor.
Conclusions Child catastrophizing about parent pain is a potential vulnerability factor associated with poor pain-related outcomes in children of parents with chronic pain that should be considered in future research and clinical settings. Statement of contribution What is already known on this subject? Higher rates of pain and internalizing symptoms are observed in offspring of parents with vs. without chronic pain. Greater child and parent pain catastrophizing are associated with poorer pain-related outcomes in children. Child catastrophizing about parent chronic pain and its association with child outcomes has not been ...
Source: British Journal of Health Psychology - March 20, 2020 Category: Psychiatry & Psychology Authors: Higgins KS, Chambers CT, Rosen NO, Sherry S, Mohammadi S, Lynch ME, Campbell-Yeo M, Clark AJ Tags: Br J Health Psychol Source Type: research

Toll-like receptor 7 contributes to neuropathic pain by activating NF- κB in primary sensory neurons.
Toll-like receptor 7 contributes to neuropathic pain by activating NF-κB in primary sensory neurons. Brain Behav Immun. 2020 Mar 20;: Authors: He L, Han G, Wu S, Du S, Zhang Y, Liu W, Jiang B, Zhang L, Xia S, Jia S, Hannaford S, Xu Y, Tao YX Abstract Toll like receptor 7 (TLR7) is expressed in neurons of the dorsal root ganglion (DRG), but whether it contributes to neuropathic pain is elusive. We found that peripheral nerve injury caused by ligation of the fourth lumbar (L4) spinal nerve (SNL) or chronic constriction injury of sciatic nerve led to a significant increase in the expression of TLR7...
Source: Brain, Behavior, and Immunity - March 20, 2020 Category: Neurology Authors: He L, Han G, Wu S, Du S, Zhang Y, Liu W, Jiang B, Zhang L, Xia S, Jia S, Hannaford S, Xu Y, Tao YX Tags: Brain Behav Immun Source Type: research

Brain Functional Alternations of the Pain-related Emotional and Cognitive Regions in Patients with Chronic Shoulder Pain
(Source: Journal of Pain Research)
Source: Journal of Pain Research - March 19, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Use of opioids for chronic non-cancer pain.
Authors: Palop Larrea V, Martinez-Mir I PMID: 32183985 [PubMed - as supplied by publisher] (Source: Medicina Clinica)
Source: Medicina Clinica - March 19, 2020 Category: General Medicine Tags: Med Clin (Barc) Source Type: research

Appropriate referral and selection of patients with chronic pain for Spinal Cord Stimulation: European consensus recommendations and e ‐health tool
ConclusionsThe RUAM was useful to establish a consensus on patient ‐specific criteria for referral/selection for SCS in chronic pain. The e‐health tool may help physicians learn to apply an integrated approach of clinical and psychosocial factors.SignificanceDetermining the eligibility of Spinal Cord Stimulation in patients with chronic pain requires careful consideration of a variety of clinical and psychosocial factors. Using a systematic approach to combine evidence from clinical studies and expert opinion, a multidisciplinary European expert panel developed detailed recommendations to support appropriate referral a...
Source: European Journal of Pain - March 19, 2020 Category: Anesthesiology Authors: Simon Thomson, Frank Huygen, Simon Prangnell, Jos é De Andrés, Ganesan Baranidharan, Hayat Belaïd, Neil Berry, Bart Billet, Jan Cooil, Giuliano De Carolis, Laura Demartini, Sam Eldabe, Kliment Gatzinsky, Jan Willem Kallewaard, Kaare Meier Tags: ORIGINAL ARTICLE Source Type: research

Can concurrent lower gastrointestinal manifestations help the timely diagnosis of small intestinal bacterial overgrowth in CVID patients?
Conclusions.Regarding the high prevalence and non-specific manifestation of SIBO, it is suggested to consider concurrent symptoms in patients with CVID to manage the timely and precise diagnosis of SIBO. PMID: 32186350 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - March 19, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

MeCP2 mediates transgenerational transmission of chronic pain
Publication date: Available online 18 March 2020Source: Progress in NeurobiologyAuthor(s): Wenjuan Tao, Changmao Chen, Yuping Wang, Wenjie Zhou, Yan Jin, Yu Mao, Haitao Wang, Likui Wang, Wen Xie, Xulai Zhang, Jie Li, Juan Li, Xiangyao Li, Zhen-Quan Tang, Chenghua Zhou, Zhizhong Z. Pan, Zhi Zhang (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - March 19, 2020 Category: Neuroscience Source Type: research

[Efficacy of ultrasound guided suprascapular block in patients with chronic shoulder pain: retrospective observational study].
Authors: Sá Malheiro N, Afonso NR, Pereira D, Oliveira B, Ferreira C, Cunha AC Abstract INTRODUCTION: Painful shoulder syndrome is a frequent condition among the elderly and an important cause of functional disability. As the conservative is not always effective, ultrasound guided suprascapular nerve blockade presents as an important alternative treatment. OBJECTIVE: To evaluate the efficacy and safety of the use of 0.25% levobupivacaine and 40 mg of triamcinolone in the suprascapular nerve blockade in patients with chronic pain in the shoulder. METHODS: A retrospective, descriptive and analytical st...
Source: Revista Brasileira de Anestesiologia - March 19, 2020 Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research

The Micro-Immunotherapy Medicine 2LARTH ® Reduces Inflammation and Symptoms of Rheumatoid Arthritis In Vivo.
The Micro-Immunotherapy Medicine 2LARTH® Reduces Inflammation and Symptoms of Rheumatoid Arthritis In Vivo. Int J Rheumatol. 2020;2020:1594573 Authors: Floris I, García-González V, Palomares B, Appel K, Lejeune B Abstract Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, which can cause cartilage and bone damages as well as pain and disability. In order to prevent disease progression, reduce pain, and major symptoms of RA, one good strategy consists in targeting proinflammatory cytokines that have the key role in the vicious circle of synovial inflammation...
Source: International Journal of Rheumatology - March 19, 2020 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Attitudes toward and Barriers to Acetaminophen Use in the Chronic Pain Population: A Cross-Sectional Study.
Authors: Foo RMC, Hoff C, Sekhri NK, Weber G Abstract The use of acetaminophen is recommended in pain management, particularly acute pain management, to reduce opioid utilization and opioid related adverse drug events. Acetaminophen's role in chronic pain conditions is understudied. This cross-sectional study was performed in a pain management office to explore how chronic pain patients use acetaminophen. The final study sample included 100 patients. Current users of acetaminophen were most likely to report that a doctor had recommended acetaminophen to them (86.4%) compared to ever (66.7%) and never (55.6%) users (p
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 19, 2020 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Healthcare Expenditures Associated with Persistent Opioid use Among Adults with Chronic Non-Cancer Pain Conditions: A Retrospective Cohort Study.
The objective of our study was to estimate the healthcare expenditures associated with persistent opioid use among adults with CNCP from both payer and patient perspectives. A retrospective cohort study using data from the Medical Expenditure Panel Survey (2012-2015) was undertaken. Patients with persistent, intermittent, and no opioid use in the baseline year were identified and their healthcare expenditures in the follow-up year were examined after controlling for potential confounders. In all, 7,286 adults with CNCP matching our inclusion criteria were identified: 14%, 16%, and 70% reported persistent, intermittent, and...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 19, 2020 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Discussion on: Surgical treatment for chronic postoperative inguinal pain-short term outcomes of a specialized center
Publication date: March 2020Source: The American Journal of Surgery, Volume 219, Issue 3Author(s): D.M. Krpata, L. Tastaldi, C.C. Petro, A. Fafaj, S. Rosenblatt, A.S. Prabhu (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - March 19, 2020 Category: Surgery Source Type: research

Surgical treatment for chronic postoperative inguinal pain-short term outcomes of a specialized center
Publication date: March 2020Source: The American Journal of Surgery, Volume 219, Issue 3Author(s): Aldo Fafaj, Luciano Tastaldi, Hemasat Alkhatib, Samuel Zolin, Diya Alaedeen, Clayton Petro, Ajita S. Prabhu, Steven Rosenblatt, Michael J. Rosen, David M. Krpata (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - March 19, 2020 Category: Surgery Source Type: research

Smaller Inguinal Hernias are Independent Risk Factors for Developing Chronic Postoperative Inguinal Pain (CPIP): A Registry-based Multivariable Analysis of 57, 999 Patients
Objective: Impact of inguinal hernia defect size as stratified by the European Hernia Society (EHS) classification I to III on the rate of chronic postoperative inguinal pain (CPIP). Background: CPIP is the most important complication after inguinal hernia repair. The impact of hernia defect size according to the EHS classification on CPIP is unknown. Methods: In total, 57,999 male patients from the Herniamed registry undergoing primary unilateral inguinal hernia repair including a 1-year follow-up were selected between September 1, 2009 and November 30, 2016. Using multivariable analysis, the impact of EHS inguina...
Source: Annals of Surgery - March 19, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

The role of glycosaminoglycans in the management of chronic pelvic pain: a systematic review.
CONCLUSIONS: GAGs replenishment therapy results are encouraging in chronic forms of pelvic pain even though well-powered randomized clinical trials are needed to better comprehend the exact role of this treatment. PMID: 32182229 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - March 19, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Simultaneous intrathecal injection of muscimol and endomorphin ‐1 alleviates neuropathic pain in rat model of spinal cord injury
ConclusionSimultaneous administration of muscimol and endomorphine ‐1 could be a new candidate for alleviation of pain resulting from spinal cord injury. (Source: Brain and Behavior)
Source: Brain and Behavior - March 19, 2020 Category: Neurology Authors: Marjan Hosseini, Zohreh Karami, Mahmood Yousefifard, Atousa Janzadeh, Elham Zamani, Farinaz Nasirinezhad Tags: ORIGINAL RESEARCH Source Type: research

Non-opioid pharmacologic treatment of chronic spinal cord injury-related pain.
Conclusions: The complex clinical situation of each individual patient must be weighed against the risks and benefits of each medication, as reviewed in this paper, to determine the ideal treatment strategy for chronic spinal cord injury-related pain. PMID: 32182196 [PubMed - as supplied by publisher] (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - March 19, 2020 Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research

Necessary components of psychological treatment in pain management programs: A Delphi study
ConclusionsThere was a consensus that there were many desirable strategies to include in psychological chronic pain management approaches, but that treatments should include psychoeducation, approaches to increase activity and cognitive approaches as a first line of intervention. Where patients fail to benefit from these approaches, experts identified other desirable strategies that could be utilized. (Source: European Journal of Pain)
Source: European Journal of Pain - March 19, 2020 Category: Anesthesiology Authors: Louise Sharpe, Emma Jones, Claire E. Ashton ‐James, Michael K. Nicholas, Kathryn Refshauge Tags: ORIGINAL ARTICLE Source Type: research

Relationship between the prevalence of soft tissue radiopacities on panoramic radiographs and medical conditions.
This study aimed to describe radiographic characteristics and the prevalence of selected anatomical structures and soft tissue radiopacities on panoramic radiographs and their relationship to medical conditions. METHODS: A retrospective cross-sectional study was conducted with 814 consecutive patients aged 35-88 years and their panoramic radiographs. Soft tissue calcifications found in the mandibular angle area were recorded according to gender, age, and bilaterally. Patient medical records were reviewed for atherogenic risk factors including hypertension, diabetes, dyslipidemia, chronic renal disease, menopause, drug ...
Source: Minerva Stomatologica - March 19, 2020 Category: Dentistry Tags: Minerva Stomatol Source Type: research

Management of functional neurological disorder
AbstractFunctional neurological disorder (FND) is a common cause of persistent and disabling neurological symptoms. These symptoms are varied and include abnormal control of movement, episodes of altered awareness resembling epileptic seizures and abnormal sensation and are often comorbid with chronic pain, fatigue and cognitive symptoms. There is increasing evidence for the role of neurologists in both the assessment and management of FND. The aim of this review is to discuss strategies for the management of FND by focusing on the diagnostic discussion and general principles, as well as specific treatment strategies for v...
Source: Journal of Neurology - March 19, 2020 Category: Neurology Source Type: research