C-X-C Motif Chemokine 10 Contributes to the Development of Neuropathic Pain by Increasing the Permeability of the Blood –Spinal Cord Barrier
Neuropathic pain is among the most debilitating forms of chronic pain. Studies have suggested that chronic pain pathogenesis involves neuroimmune interactions and blood–spinal cord barrier (BSCB) disruption. However, the underlying mechanisms are poorly understood. We modeled neuropathic pain in rats by inducing chronic constriction injury (CCI) of the sciatic nerve and analyzed the effects on C-X-C motif chemokine 10 (CXCL10)/CXCR3 activation, BSCB permeability, and immune cell migration from the circulation into the spinal cord. We detected CXCR3 expression in spinal neurons and observed that CCI induced CXCL10/CXC...
Source: Frontiers in Immunology - March 20, 2020 Category: Allergy & Immunology Source Type: research

Challenges in the Provision of End-of-life and Palliative Care to Ethnic Nepali Refugees
After over a decade of resettlement of ethnic Nepali refugees in the United States, a significant population of seriously ill refugees will require palliative care and hospice care. The refugee experience and culturally specific factors affect the end-of-life care of this population. Challenges in the end-of-life care of Nepali refugees include challenges related to social and health inequities such as significant chronic respiratory disease burden, lack of protocols for deferral of illness disclosure, lack of support for group decision making, unfamiliarity with spiritual, religious and traditional health practices and di...
Source: Journal of Pain and Symptom Management - March 20, 2020 Category: Palliative Care Authors: Salim N. Najjar, Fern R. Hauck Tags: Special Article Source Type: research

Child catastrophizing about parent chronic pain: A potential child vulnerability factor.
Conclusions Child catastrophizing about parent pain is a potential vulnerability factor associated with poor pain-related outcomes in children of parents with chronic pain that should be considered in future research and clinical settings. Statement of contribution What is already known on this subject? Higher rates of pain and internalizing symptoms are observed in offspring of parents with vs. without chronic pain. Greater child and parent pain catastrophizing are associated with poorer pain-related outcomes in children. Child catastrophizing about parent chronic pain and its association with child outcomes has not been ...
Source: British Journal of Health Psychology - March 20, 2020 Category: Psychiatry & Psychology Authors: Higgins KS, Chambers CT, Rosen NO, Sherry S, Mohammadi S, Lynch ME, Campbell-Yeo M, Clark AJ Tags: Br J Health Psychol Source Type: research

Toll-like receptor 7 contributes to neuropathic pain by activating NF- κB in primary sensory neurons.
Toll-like receptor 7 contributes to neuropathic pain by activating NF-κB in primary sensory neurons. Brain Behav Immun. 2020 Mar 20;: Authors: He L, Han G, Wu S, Du S, Zhang Y, Liu W, Jiang B, Zhang L, Xia S, Jia S, Hannaford S, Xu Y, Tao YX Abstract Toll like receptor 7 (TLR7) is expressed in neurons of the dorsal root ganglion (DRG), but whether it contributes to neuropathic pain is elusive. We found that peripheral nerve injury caused by ligation of the fourth lumbar (L4) spinal nerve (SNL) or chronic constriction injury of sciatic nerve led to a significant increase in the expression of TLR7...
Source: Brain, Behavior, and Immunity - March 20, 2020 Category: Neurology Authors: He L, Han G, Wu S, Du S, Zhang Y, Liu W, Jiang B, Zhang L, Xia S, Jia S, Hannaford S, Xu Y, Tao YX Tags: Brain Behav Immun Source Type: research

Brain Functional Alternations of the Pain-related Emotional and Cognitive Regions in Patients with Chronic Shoulder Pain
(Source: Journal of Pain Research)
Source: Journal of Pain Research - March 19, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Use of opioids for chronic non-cancer pain.
Authors: Palop Larrea V, Martinez-Mir I PMID: 32183985 [PubMed - as supplied by publisher] (Source: Medicina Clinica)
Source: Medicina Clinica - March 19, 2020 Category: General Medicine Tags: Med Clin (Barc) Source Type: research

Appropriate referral and selection of patients with chronic pain for Spinal Cord Stimulation: European consensus recommendations and e ‐health tool
ConclusionsThe RUAM was useful to establish a consensus on patient ‐specific criteria for referral/selection for SCS in chronic pain. The e‐health tool may help physicians learn to apply an integrated approach of clinical and psychosocial factors.SignificanceDetermining the eligibility of Spinal Cord Stimulation in patients with chronic pain requires careful consideration of a variety of clinical and psychosocial factors. Using a systematic approach to combine evidence from clinical studies and expert opinion, a multidisciplinary European expert panel developed detailed recommendations to support appropriate referral a...
Source: European Journal of Pain - March 19, 2020 Category: Anesthesiology Authors: Simon Thomson, Frank Huygen, Simon Prangnell, Jos é De Andrés, Ganesan Baranidharan, Hayat Belaïd, Neil Berry, Bart Billet, Jan Cooil, Giuliano De Carolis, Laura Demartini, Sam Eldabe, Kliment Gatzinsky, Jan Willem Kallewaard, Kaare Meier Tags: ORIGINAL ARTICLE Source Type: research

Can concurrent lower gastrointestinal manifestations help the timely diagnosis of small intestinal bacterial overgrowth in CVID patients?
Conclusions.Regarding the high prevalence and non-specific manifestation of SIBO, it is suggested to consider concurrent symptoms in patients with CVID to manage the timely and precise diagnosis of SIBO. PMID: 32186350 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - March 19, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

MeCP2 mediates transgenerational transmission of chronic pain
Publication date: Available online 18 March 2020Source: Progress in NeurobiologyAuthor(s): Wenjuan Tao, Changmao Chen, Yuping Wang, Wenjie Zhou, Yan Jin, Yu Mao, Haitao Wang, Likui Wang, Wen Xie, Xulai Zhang, Jie Li, Juan Li, Xiangyao Li, Zhen-Quan Tang, Chenghua Zhou, Zhizhong Z. Pan, Zhi Zhang (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - March 19, 2020 Category: Neuroscience Source Type: research

[Efficacy of ultrasound guided suprascapular block in patients with chronic shoulder pain: retrospective observational study].
Authors: Sá Malheiro N, Afonso NR, Pereira D, Oliveira B, Ferreira C, Cunha AC Abstract INTRODUCTION: Painful shoulder syndrome is a frequent condition among the elderly and an important cause of functional disability. As the conservative is not always effective, ultrasound guided suprascapular nerve blockade presents as an important alternative treatment. OBJECTIVE: To evaluate the efficacy and safety of the use of 0.25% levobupivacaine and 40 mg of triamcinolone in the suprascapular nerve blockade in patients with chronic pain in the shoulder. METHODS: A retrospective, descriptive and analytical st...
Source: Revista Brasileira de Anestesiologia - March 19, 2020 Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research

The Micro-Immunotherapy Medicine 2LARTH ® Reduces Inflammation and Symptoms of Rheumatoid Arthritis In Vivo.
The Micro-Immunotherapy Medicine 2LARTH® Reduces Inflammation and Symptoms of Rheumatoid Arthritis In Vivo. Int J Rheumatol. 2020;2020:1594573 Authors: Floris I, García-González V, Palomares B, Appel K, Lejeune B Abstract Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, which can cause cartilage and bone damages as well as pain and disability. In order to prevent disease progression, reduce pain, and major symptoms of RA, one good strategy consists in targeting proinflammatory cytokines that have the key role in the vicious circle of synovial inflammation...
Source: International Journal of Rheumatology - March 19, 2020 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Attitudes toward and Barriers to Acetaminophen Use in the Chronic Pain Population: A Cross-Sectional Study.
Authors: Foo RMC, Hoff C, Sekhri NK, Weber G Abstract The use of acetaminophen is recommended in pain management, particularly acute pain management, to reduce opioid utilization and opioid related adverse drug events. Acetaminophen's role in chronic pain conditions is understudied. This cross-sectional study was performed in a pain management office to explore how chronic pain patients use acetaminophen. The final study sample included 100 patients. Current users of acetaminophen were most likely to report that a doctor had recommended acetaminophen to them (86.4%) compared to ever (66.7%) and never (55.6%) users (p
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 19, 2020 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Healthcare Expenditures Associated with Persistent Opioid use Among Adults with Chronic Non-Cancer Pain Conditions: A Retrospective Cohort Study.
The objective of our study was to estimate the healthcare expenditures associated with persistent opioid use among adults with CNCP from both payer and patient perspectives. A retrospective cohort study using data from the Medical Expenditure Panel Survey (2012-2015) was undertaken. Patients with persistent, intermittent, and no opioid use in the baseline year were identified and their healthcare expenditures in the follow-up year were examined after controlling for potential confounders. In all, 7,286 adults with CNCP matching our inclusion criteria were identified: 14%, 16%, and 70% reported persistent, intermittent, and...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 19, 2020 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Discussion on: Surgical treatment for chronic postoperative inguinal pain-short term outcomes of a specialized center
Publication date: March 2020Source: The American Journal of Surgery, Volume 219, Issue 3Author(s): D.M. Krpata, L. Tastaldi, C.C. Petro, A. Fafaj, S. Rosenblatt, A.S. Prabhu (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - March 19, 2020 Category: Surgery Source Type: research

Surgical treatment for chronic postoperative inguinal pain-short term outcomes of a specialized center
Publication date: March 2020Source: The American Journal of Surgery, Volume 219, Issue 3Author(s): Aldo Fafaj, Luciano Tastaldi, Hemasat Alkhatib, Samuel Zolin, Diya Alaedeen, Clayton Petro, Ajita S. Prabhu, Steven Rosenblatt, Michael J. Rosen, David M. Krpata (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - March 19, 2020 Category: Surgery Source Type: research

Smaller Inguinal Hernias are Independent Risk Factors for Developing Chronic Postoperative Inguinal Pain (CPIP): A Registry-based Multivariable Analysis of 57, 999 Patients
Objective: Impact of inguinal hernia defect size as stratified by the European Hernia Society (EHS) classification I to III on the rate of chronic postoperative inguinal pain (CPIP). Background: CPIP is the most important complication after inguinal hernia repair. The impact of hernia defect size according to the EHS classification on CPIP is unknown. Methods: In total, 57,999 male patients from the Herniamed registry undergoing primary unilateral inguinal hernia repair including a 1-year follow-up were selected between September 1, 2009 and November 30, 2016. Using multivariable analysis, the impact of EHS inguina...
Source: Annals of Surgery - March 19, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

The role of glycosaminoglycans in the management of chronic pelvic pain: a systematic review.
CONCLUSIONS: GAGs replenishment therapy results are encouraging in chronic forms of pelvic pain even though well-powered randomized clinical trials are needed to better comprehend the exact role of this treatment. PMID: 32182229 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - March 19, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Simultaneous intrathecal injection of muscimol and endomorphin ‐1 alleviates neuropathic pain in rat model of spinal cord injury
ConclusionSimultaneous administration of muscimol and endomorphine ‐1 could be a new candidate for alleviation of pain resulting from spinal cord injury. (Source: Brain and Behavior)
Source: Brain and Behavior - March 19, 2020 Category: Neurology Authors: Marjan Hosseini, Zohreh Karami, Mahmood Yousefifard, Atousa Janzadeh, Elham Zamani, Farinaz Nasirinezhad Tags: ORIGINAL RESEARCH Source Type: research

Non-opioid pharmacologic treatment of chronic spinal cord injury-related pain.
Conclusions: The complex clinical situation of each individual patient must be weighed against the risks and benefits of each medication, as reviewed in this paper, to determine the ideal treatment strategy for chronic spinal cord injury-related pain. PMID: 32182196 [PubMed - as supplied by publisher] (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - March 19, 2020 Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research

Necessary components of psychological treatment in pain management programs: A Delphi study
ConclusionsThere was a consensus that there were many desirable strategies to include in psychological chronic pain management approaches, but that treatments should include psychoeducation, approaches to increase activity and cognitive approaches as a first line of intervention. Where patients fail to benefit from these approaches, experts identified other desirable strategies that could be utilized. (Source: European Journal of Pain)
Source: European Journal of Pain - March 19, 2020 Category: Anesthesiology Authors: Louise Sharpe, Emma Jones, Claire E. Ashton ‐James, Michael K. Nicholas, Kathryn Refshauge Tags: ORIGINAL ARTICLE Source Type: research

Relationship between the prevalence of soft tissue radiopacities on panoramic radiographs and medical conditions.
This study aimed to describe radiographic characteristics and the prevalence of selected anatomical structures and soft tissue radiopacities on panoramic radiographs and their relationship to medical conditions. METHODS: A retrospective cross-sectional study was conducted with 814 consecutive patients aged 35-88 years and their panoramic radiographs. Soft tissue calcifications found in the mandibular angle area were recorded according to gender, age, and bilaterally. Patient medical records were reviewed for atherogenic risk factors including hypertension, diabetes, dyslipidemia, chronic renal disease, menopause, drug ...
Source: Minerva Stomatologica - March 19, 2020 Category: Dentistry Tags: Minerva Stomatol Source Type: research

Management of functional neurological disorder
AbstractFunctional neurological disorder (FND) is a common cause of persistent and disabling neurological symptoms. These symptoms are varied and include abnormal control of movement, episodes of altered awareness resembling epileptic seizures and abnormal sensation and are often comorbid with chronic pain, fatigue and cognitive symptoms. There is increasing evidence for the role of neurologists in both the assessment and management of FND. The aim of this review is to discuss strategies for the management of FND by focusing on the diagnostic discussion and general principles, as well as specific treatment strategies for v...
Source: Journal of Neurology - March 19, 2020 Category: Neurology Source Type: research

How to Use Methadone in an Era of an Opioid Epidemic
Opinion statementThe opioid epidemic is one of the most important public health crises as opioid-related deaths have become a leading cause of accidental death in the USA. Various efforts have been made to understand how to safely and appropriately prescribe opioids for patients with chronic pain, including those with cancer-related pain. We find the guidelines proposed by the Expert Consensus White Paper on the use of methadone to be current, comprehensive, and practical. While methadone is a complex medication with unique pharmacokinetics and pharmacodynamics, it remains a superior choice for many patients with cancer pa...
Source: Current Treatment Options in Oncology - March 19, 2020 Category: Cancer & Oncology Source Type: research

Bulleyaconitine A Exerts Antianxiety and Antivisceral Hypersensitivity Effects
In conclusion, our study demonstrated, for the first time, that BAA exerted marked antivisceral pain and antianxiety effects, which expands the analgesic spectrum and clinical application of BAA. Furthermore, it also it provides a better guidance for the clinical use of BAA. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 19, 2020 Category: Drugs & Pharmacology Source Type: research

Safety and Efficacy of Ubrogepant for the Acute Treatment of Episodic Migraine: A Meta-Analysis of Randomized Clinical Trials
ConclusionsThe use of ubrogepant as an acute treatment of episodic migraine in adults led to a greater percentage of freedom from pain and absence of the most bothersome symptoms at 2 h post-dose. Short-term use of ubrogepant was not related to an increased risk for adverse events. Further studies are needed to evaluate efficacy and safety for long-term use and in specific subgroups of patients. (Source: CNS Drugs)
Source: CNS Drugs - March 19, 2020 Category: Neurology Source Type: research

Recommendations for MRI technique in the evaluation of pelvic endometriosis: consensus statement from the Society of Abdominal Radiology endometriosis disease-focused panel
AbstractEndometriosis is a common entity causing chronic pain and infertility in women. The gold standard method for diagnosis is diagnostic laparoscopy, which is invasive and costly. MRI has shown promise in its ability to diagnose endometriosis and its efficacy for preoperative planning. The Society of Abdominal Radiology established a Disease-Focused Panel (DFP) to improve patient care for patients with endometriosis. In this article, the DFP performs a literature review and uses its own experience to provide technical recommendations on optimizing MRI Pelvis for the evaluation of endometriosis. (Source: Abdominal Imaging)
Source: Abdominal Imaging - March 19, 2020 Category: Radiology Source Type: research

Characterisation of the effects of pulsed radio frequency treatment of the dorsal root ganglion on cerebrospinal fluid cellular and peptide constituents in patients with chronic radicular pain: A randomised, triple-blinded, controlled trial
This study aims to characterise the CSF cellular and peptide constituents in patients with CNP and the effect of pulsed radiofrequency (PRF) on these constituents and reported pain. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - March 19, 2020 Category: Allergy & Immunology Authors: David Moore, Deborah Galvin, Melissa Conroy, Basabjit Das, Margaret Dunne, Joanne Lysaght, Connail McCrory Source Type: research

[Pain management in osteoporosis].
This article gives a comprehensive review of pain management in osteoporosis and also explains the underlying pathomechanisms, risk factors, and diagnostic procedures. PMID: 32193562 [PubMed - as supplied by publisher] (Source: Der Orthopade)
Source: Der Orthopade - March 19, 2020 Category: Orthopaedics Authors: Heuchemer L, Emmert D, Bender T, Rasche T, Marinova M, Kasapovic A, Conrad R, Mücke M Tags: Orthopade Source Type: research

Study on chemical modification and analgesic activity of N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl) piperazine-1-carboxamide.
Abstract N-(4-Tert-butylphenyl)-4-(3-chloropyridin-2-yl) piperazine-1-carboxamide (BCTC) is a potent and extensively studied urea-based TRPV1 antagonist. Although BCTC was effective in alleviating chronic pain in rats, it showed obvious hyperthermia side-effect and unsatisfactory pharmacokinetic profile, therefore, it was not developed further. In order to enrich the structural types of urea-based TRPV1 antagonists, two series of novel analogs, in which the pyridine ring of BCTC was replaced with a mildly basic pyrimidine ring or 1,2,3,4-tetrahydro-β-carboline scaffold, were designed and synthesized. Advancin...
Source: European Journal of Medicinal Chemistry - March 19, 2020 Category: Chemistry Authors: Nie C, Li Q, Qiao Y, Hu J, Gao M, Wang Y, Qiao Z, Wang Q, Yan L, Qian H Tags: Eur J Med Chem Source Type: research

Effects of sweet orange aromatherapy on pain and anxiety during needle insertion among patients undergoing hemodialysis: A quasi ‐experimental study
ConclusionThe sweet orange aromatherapy can be effective in reducing pain and anxiety. Thus, this can be used by nurses as an alternative and complementary approach to reduce both pain and anxiety in painful procedures like needle insertion. (Source: Nursing Forum)
Source: Nursing Forum - March 18, 2020 Category: Nursing Authors: Ma. Catherine Grace Mendoza Reyes, Ma. Corrine Grace Mendoza Reyes, Krystal Gale Lastrella Ribay, Emmanuel Dayao Paragas Tags: ORIGINAL ARTICLE Source Type: research

A twelve ‐week, four‐arm, randomized, double‐blind, placebo‐controlled, phase 2 prospective clinical trial to evaluate the efficacy and safety of an anthroposophic multimodal treatment on chronic pain in outpatients with postpolio syndrome
ConclusionsThe anthroposophic multimodal treatment group presented both safety and efficacy as an analgesic in the groups that received the nonpharmacological therapies, much earlier when associated with the ETG. The multimodal approach corresponded to the pattern of better efficacy for both pain reduction and improvement in quality of life and resilience. (Source: Brain and Behavior)
Source: Brain and Behavior - March 18, 2020 Category: Neurology Authors: Ricardo Ghelman, Ivete Y. Akiyama, Valeria T. Souza, Jussara Falc ão, Vera Orgolini, Jorge K. Hosomi, Abrahão A. J. Quadros, Acary S. B. Oliveira Tags: ORIGINAL RESEARCH Source Type: research

Treatment of chronic anal fissure: a feasibility study on Levorag ® Emulgel versus Diltiazem gel 2%
ConclusionThe study demonstrated statistical non-inferiority of Levorag ® Emulgel compared with diltiazem in the treatment of chronic anal fissure. Diltiazem resulted in a more prompt pain relief and also in a substantial number of local allergic reactions. Levorag® Emulgel may therefore be an alternative in these patients.Trial registrationClinicaltrials.gov no. NCT02158013 (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - March 18, 2020 Category: Gastroenterology Source Type: research

Pilot Study in Temporary Peripheral Nerve Stimulation in Oncologic Pain
ConclusionsPNS has potential uses in the treatment of oncologic pain. Further high ‐quality studies should be designed to further elucidate use of the PNS to treat oncologic pain. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - March 18, 2020 Category: Biotechnology Authors: Ojas Mainkar, Che Antonio Sollo, Grant Chen, Aron Legler, Amitabh Gulati Tags: Case Series Source Type: research

Leptospirosis: a six-case report from west black sea, Turkey.
In conclusion, the possibility of leptospirosis should be considered in patients presenting with non-specific symptoms such as fever and muscle pain and developing thrombocytopenia, and liver and kidney function disorder. Risk factors should also be investigated when taking histories. Early diagnosis and antibiotic therapy being started as quickly as possible are important in terms of the course of the disease. PMID: 32172267 [PubMed - in process] (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - March 18, 2020 Category: Infectious Diseases Tags: Infez Med Source Type: research

The Use of Telepain for Chronic Pain in the U.S. Armed Forces: Patient Experience from Walter Reed National Military Medical Center.
CONCLUSIONS: The majority of pain specialists within the Military Health System are located at major military medical centers, the most of which are distant from surrounding MTFs. Prior to the development of the WRNMMC Telepain service, personnel at remote MTFs had to endure extended time away from their mission to receive care. The majority of patients that participated in the NCR Telepain program reported a positively perceived impact on pain, access to care, quality of life, transportation burden, and time away from work. In conclusion, The NCR Telepain team of providers have worked together to successfully establish a ...
Source: Military Medicine - March 18, 2020 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Outpatient Pharmacy Prescriptions During the First Year Following Serious Combat Injury: A Retrospective Analysis.
CONCLUSIONS: This is one of the first studies to provide a systematic analysis of outpatient medication prescriptions following serious combat injury. The results indicate substantial prescription activity from multiple medication categories throughout the first-year postinjury. Diagnoses of chronic pain, PTSD, and limb amputation and ISS were associated with significantly higher counts of prescriptions overall and more prescription medication categories. This study provides initial evidence to better understand medication prescription activity following serious combat injury. The results inform future research on medicati...
Source: Military Medicine - March 18, 2020 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Musculoskeletal Injuries and United States Army Readiness Part I: Overview of Injuries and their Strategic Impact.
CONCLUSIONS: MSKIs significantly impact soldier health and U.S. Army readiness. MSKIs also figure prominently in medical disability discharges and long-term, service-connected disability costs. MSKI patterns and trends vary between trainees and soldiers in operational units and among military occupations and types of operational units. Coordinated injury surveillance efforts are needed to provide standardized metrics and accurately measure temporal changes in injury rates. PMID: 32175566 [PubMed - as supplied by publisher] (Source: Military Medicine)
Source: Military Medicine - March 18, 2020 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

[Comparison between erector spinal plane block and epidural block techniques for postoperative analgesia in open cholecystectomies: a randomized clinical trial].
CONCLUSION: ESP block did not prove to be an effective technique for postoperative analgesia of open cholecystectomy, at the doses performed in this study, having required more use of rescue opioid, and without differences in NPS. More comprehensive studies are required to assess the efficacy of ESP block for the visceral and abdominal somatic component, considering the specific blockade level. PMID: 32171499 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Anestesiologia)
Source: Revista Brasileira de Anestesiologia - March 18, 2020 Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research

Machine Learning Diagnostic Modeling for Classifying Fibromyalgia Using B-mode Ultrasound Images.
Authors: Behr M, Saiel S, Evans V, Kumbhare D Abstract Fibromyalgia (FM) diagnosis remains a challenge for clinicians due to a lack of objective diagnostic tools. One proposed solution is the use of quantitative ultrasound (US) techniques, such as image texture analysis, which has demonstrated discriminatory capabilities with other chronic pain conditions. From this, we propose the use of image texture variables to construct and compare two machine learning models (support vector machine [SVM] and logistic regression) for differentiating between the trapezius muscle in healthy and FM patients. US videos of the righ...
Source: Ultrasonic Imaging - March 18, 2020 Category: Radiology Tags: Ultrason Imaging Source Type: research

Pain assessment for chronic lower back pain: performance of the PAL-S and PAL-I patient-reported measures for symptoms and impacts.
Conclusion: The PAL-S and PAL-I generated highly reliable scores with substantial evidence of construct validity. Routine use of these measures in treatment trials will enhance comparability of LBP-related symptom and impact results, including patient perspective of treatment benefit. PMID: 32175771 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Isorhynchophylline Exerts Antinociceptive Effects on Behavioral Hyperalgesia and Allodynia in a Mouse Model of Neuropathic Pain: Evidence of a 5-HT1A Receptor-Mediated Mechanism
Chronic neuropathic pain poses a significant health problem, for which effective therapy is lacking. The current work aimed to investigate the potential antinociceptive efficacy of isorhynchophylline, an oxindole alkaloid, against neuropathic pain and elucidate mechanisms. Male C57BL/6J mice were subjected to chronic constriction injury (CCI) by loose ligation of their sciatic nerves. Following CCI surgery, the neuropathic mice developed pain-like behaviors, as shown by thermal hyperalgesia in the Hargreaves test and tactile allodynia in the von Frey test. Repetitive treatment of CCI mice with isorhynchophylline (p.o., twi...
Source: Frontiers in Pharmacology - March 18, 2020 Category: Drugs & Pharmacology Source Type: research

Meta-Analysis of Efficacy of Rhubarb Combined With Early Enteral Nutrition for the Treatment of Severe Acute Pancreatitis.
This study aimed to systematically explore the efficacy and safety of rhubarb/EEN in SAP patients. METHODS: We performed searches in EMBASE, PubMed, Medline, Cochrane Library, Chinese Biomedicine Literature Database (SinoMed), Chinese Scientific Journal Database (VIP), Chinese National Knowledge Infrastructure (CNKI), and Wanfang database to identify relevant literature comparing rhubarb/EEN with EEN for SAP. RESULTS: Eleven randomized controlled trials (724 patients) were included. Meta-analysis showed significantly shorter length of hospital stay (days) (mean difference [MD], -4.49; 95% CI, -6.09 to -2.90; P
Source: JPEN Journal Of Parenteral And Enteral Nutrition - March 18, 2020 Category: Nutrition Authors: Chen X, Yang K, Jing G, Yang J, Li K Tags: JPEN J Parenter Enteral Nutr Source Type: research

[From why to what for : On the relevance of a  philosophical-existentialistic approach in the treatment of patients with chronic pain].
[From why to what for : On the relevance of a philosophical-existentialistic approach in the treatment of patients with chronic pain]. Schmerz. 2020 Mar 18;: Authors: Bozzaro C, Koesling D, Frede U Abstract BACKGROUND: People have the need to find explanations for the events that occur in their lives. This is especially true when it comes to experiences that impact a person's entire existence and endanger their self-esteem and sense of identity. Chronic pain is one such experience. The search for the cause behind such pain is primarily motivated by the expectation that once the cause of the ...
Source: Schmerz - March 18, 2020 Category: Anesthesiology Authors: Bozzaro C, Koesling D, Frede U Tags: Schmerz Source Type: research

Can measuring passive neck muscle stiffness in whiplash injury patients help detect false whiplash claims?
This study included 75 whiplash injury patients and 75 control subjects. Trapezius, splenius capitis and sternocleidomastoid muscles were examined by ultrasound shear wave elastography. RESULTS: Increased muscle stiffness was noticed in trapezius muscle bilaterally in the whiplash group when compared to the control group (p 
Source: Wiener Klinische Wochenschrift - March 18, 2020 Category: General Medicine Authors: Aljinović J, Barišić I, Poljičanin A, Kuzmičić S, Vukojević K, Gugić Bokun D, Vlak T Tags: Wien Klin Wochenschr Source Type: research

[Diagnostics and therapy of back pain: what is advisable? What should be avoided and why is it still done?]
Abstract Diagnostic and therapeutic procedures are popular and frequently performed for low back pain. This narrative review presents and discusses the myths and evidence related to these procedures.In most cases it is nonspecific pain, for which no underlying disease can be named. Image diagnostics using X‑rays and MRI are rarely helpful in the case of new nonspecific back pain.Evidence for chirotherapy is doubtful. Also, evidence is lacking for invasive and surgical procedures in local and regional low back pain. These procedures show superiority in radicular pain only: extraction of disc herniation in acute a...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - March 18, 2020 Category: International Medicine & Public Health Authors: Schiltenwolf M, Schwarze M Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research

Trunk-Pelvis Kinematics Variability During Gait and Its Association With Trunk Muscle Endurance in Patients With Chronic Low Back Pain.
Authors: Bagheri R, Ebrahimi Takamjani I, Pourahmadi MR, Jannati E, Fazeli SH, Hedayati R, Akbari M Abstract The first purpose was to investigate the trunk muscle endurance, the second aim was to evaluate the trunk-pelvis kinematics during gait, and the third was to evaluate the relationship between trunk-pelvis kinematics and the trunk muscle endurance. Thirty participants (15 nonspecific chronic low back pain [NCLBP] and 15 healthy) were included. The authors first assessed trunk muscle endurance on endurance testing protocols. The authors next measured the trunk-pelvis kinematics during gait using a 3-dimensiona...
Source: Journal of Applied Biomechanics - March 17, 2020 Category: Sports Medicine Tags: J Appl Biomech Source Type: research

Shoulder pain among male industrial workers: Validation of a conceptual model in two independent French working populations.
This study aims to validate a conceptual model for shoulder pain risk factors in two independent samples of male industrial workers: the Cosali cohort (n = 334) and one pharmaceutical company (n = 487). Direct and indirect relationships between work organization factors (automatic speed of a machine or movement of a product and work pace dependent on customers' demand), psychosocial factors (Job strain model), biomechanical factors (working with abducted arms, working with arms at or above shoulder level, and perceived physical exertion), perceived stress, and shoulder pain were explored using structura...
Source: Applied Ergonomics - March 17, 2020 Category: Occupational Health Authors: Bodin J, Garlantézec R, Costet N, Descatha A, Viel JF, Roquelaure Y Tags: Appl Ergon Source Type: research

Efficacy of Tuina in patients with chronic low back pain: study protocol for a randomized controlled trial
Low back pain is a common reason for medical care and carries a heavy social burden. The efficacy of Tuina or health care education for low back pain has been evaluated in previous systematic reviews. However,... (Source: Trials)
Source: Trials - March 17, 2020 Category: General Medicine Authors: Shuaipan Zhang, Lingjun Kong, Qingguang Zhu, Zhiwei Wu, Jianhua Li, Min Fang, Wuquan Sun, Yanbin Cheng, Shanda Xu, Guangxin Guo, Xin Zhou and Zhizhen Lv Tags: Study protocol Source Type: research

Cross-cultural adaptation and psychometric evaluation of the Yoruba version of the Back beliefs questionnaire among patients with chronic low-back pain
To translate, culturally adapt and conduct a psychometric evaluation of the Yoruba version of the Back Beliefs Questionnaire (BBQ) among patients with chronic low-back pain. (Source: Health and Quality of Life Outcomes)
Source: Health and Quality of Life Outcomes - March 17, 2020 Category: International Medicine & Public Health Authors: C. E. Mbada, O. A. Adeniyi, O. A. Idowu, C. T. Fatoye, A. C. Odole and F. Fatoye Tags: Research Source Type: research

The lived experience of chronic pain and dyskinesia in children and adolescents with cerebral palsy
To explore the lived experience of chronic pain and dyskinesia in children and adolescents with cerebral palsy. (Source: BMC Pediatrics)
Source: BMC Pediatrics - March 17, 2020 Category: Pediatrics Authors: Clare T. McKinnon, Jennifer H. White, Prue E. Morgan, Giuliana C. Antolovich, Catherine H. Clancy, Michael C. Fahey and Adrienne R. Harvey Tags: Research article Source Type: research