Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury.
Abstract The neurochemical mechanisms underlying neuropathic pain (NP) are related to peripheral and central sensitization caused by the release of inflammatory mediators in the peripheral damaged tissue and ectopic discharges from the injured nerve, leading to a hyperexcitable state of spinal dorsal horn neurons. The aim of this work was to clarify the role played by cyclooxygenase (COX) in the lesioned peripheral nerve in the development and maintenance of NP by evaluating at which moment the non-steroidal anti-inflammatory drug indomethacin, a non-selective COX inhibitor, attenuated mechanical allodynia after p...
Source: Braz J Med Biol Res - April 30, 2020 Category: Research Authors: Medeiros P, Dos Santos IR, Medeiros AC, da Silva JA, Ferreira SH, de Freitas RL, Coimbra NC Tags: Braz J Med Biol Res Source Type: research

[ASAP] P2Y < sub > 14 < /sub > Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00115 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - April 30, 2020 Category: Chemistry Authors: Fatma Mufti †, Young-Hwan Jung‡, Luigino Antonio Giancotti†, Jinha Yu‡, Zhoumou Chen†, Ngan B. Phung‡, Kenneth A. Jacobson*‡, and Daniela Salvemini*† Source Type: research

Chronic Pain Syndromes and Their Laryngeal Manifestations
This case series analyzes the differences in presentation of voice and laryngeal disorders in patients with fibromyalgia, irritable bowel syndrome, and/or chronic fatigue syndrome. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 30, 2020 Category: ENT & OMF Source Type: research

Polytetrafluoroethylene versus polypropylene mesh during laparoscopic totally extraperitoneal (TEP) repair of inguinal hernia: short- and long-term results of a double-blind clinical randomized controlled trial
AbstractPurposeAim of the study is to compare macroporous (>  1 mm2) polytetrafluoroethylene mesh (LP-PTFE) versus microporous (
Source: Hernia - April 30, 2020 Category: Sports Medicine Source Type: research

Local Anesthetic Injection Resolves Movement Pain, Motor Dysfunction, and Pain Catastrophizing in Individuals With Chronic Achilles Tendinopathy, a Non-Randomized Clinical Trial
Journal of Orthopaedic&Sports Physical Therapy, Ahead of Print. (Source: The Journal of Orthopaedic and Sports Physical Therapy)
Source: The Journal of Orthopaedic and Sports Physical Therapy - April 30, 2020 Category: Physiotherapy Authors: Ruth L. Chimenti Mederic M. Hall Connor P. Dilger Ericka N. Merriwether Jason M. Wilken Kathleen A. Sluka Source Type: research

Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation
In this study, we hypothesized that endothelial cells (EC) carry thePIK3CA mutations and play a major role in the cellular origin of CLVM. We isolated EC from the lesions of seven patients with CLVM and identifiedPIK3CA hotspot mutations. The CLVM EC exhibited constitutive phosphorylation of the PI3K effector AKT as well as hyperproliferation and increased resistance to cell death compared to normal EC. Inhibitors of PIK3CA (BYL719) and AKT (ARQ092) attenuated the proliferation of CLVM EC in a dose-dependent manner. A xenograft model of CLVM was developed by injecting patient-derived EC into the flanks of immunocompromised...
Source: Angiogenesis - April 30, 2020 Category: Molecular Biology Source Type: research

“Triaging” Chronic Migraine Patients in Need of CGRP(r) Monoclonal Antibodies
(Source: Pain and Therapy)
Source: Pain and Therapy - April 30, 2020 Category: Anesthesiology Source Type: research

A Balanced Approach for Cannabidiol Use in Chronic Pain
Cannabidiol (CBD), the major non-psychoactive constituent of Cannabis sativa L., has gained traction as a potential treatment for intractable chronic pain in many conditions. Clinical evidence suggests that CBD provides therapeutic benefit in certain forms of epilepsy and imparts analgesia in certain conditions, and improves quality of life. CBD continues to be Schedule I or V on the list of controlled substances of the Drug Enforcement Agency of the United States. However, preparations labeled CBD are available publicly in stores and on the streets. However, use of CBD does not always resolve pain. CBD purchased freely en...
Source: Frontiers in Pharmacology - April 30, 2020 Category: Drugs & Pharmacology Source Type: research

Criterion validity of two mobile applications to count the number of steps in older adults with chronic pain
. (Source: European Journal of Physiotherapy)
Source: European Journal of Physiotherapy - April 30, 2020 Category: Rehabilitation Authors: Jos é Ferreira Alexandra Queir ós Anabela G. Silva Source Type: research

Motivational Interviewing and Return to Work for People with Musculoskeletal Disorders: A Systematic Mapping Review
Conclusions This mapping review identified a huge gap in research on MI to increase return to work for individuals with musculoskeletal disorders.Registration Current Research Information System in Norway, project id: 635823 (https://app.cristin.no/projects/show.jsf?id=635823). (Source: Journal of Occupational Rehabilitation)
Source: Journal of Occupational Rehabilitation - April 30, 2020 Category: Rehabilitation Source Type: research

Ultrasound Parasternal Block as a Novel Approach for Cardiac Sternal Surgery: Could it Be the Safest Strategy?
Respiratory complications  are a major factor contributing to postoperative morbidity and mortality, especially in patients with chronic obstructive pulmonary disease (COPD). To minimize respiratory complications, minimally invasive approaches to cardiac surgery in addition to regional anesthesia are being used.1 Cardiac surgery most commonly is performed via median sternotomy, which results in significant intraoperative and postoperative pain and a high incidence of chronic pain. When sternal dehiscence occurs, sternal resynthesis most commonly is performed with general anesthesia and intravenous opioid adm...
Source: Journal of Cardiothoracic and Vascular Anesthesia - April 30, 2020 Category: Anesthesiology Authors: Giuseppe Sepolvere, Mario Tedesco, Loredana Cristiano Tags: Letter to the Editor Source Type: research

Fear in the context of pain: Lessons learned from 100 years of fear conditioning research.
We describe the different pain-related fear conditioning paradigms using proprioceptive and interoceptive CSs and painful stimuli as USs that have been developed to study specific forms of pain-related fear (i.e. fear of movement, fear of touch, fear of visceral sensations, and fear of penetration) that are relevant for different chronic pain conditions (i.e. musculoskeletal pain, neuropathic pain, visceral pain, and genital pain). We present evidence that patients with chronic pain demonstrate impaired safety learning and excessive fear generalization; learning anomalies that have also been observed in anxiety disorders. ...
Source: Behaviour Research and Therapy - April 30, 2020 Category: Psychiatry & Psychology Authors: Meulders A Tags: Behav Res Ther Source Type: research

10 & nbsp;kHz Spinal Cord Stimulation for Combined Alleviation of Post-Laminectomy Syndrome and Chronic Abdominal Pain: A Case Report
(Source: Journal of Pain Research)
Source: Journal of Pain Research - April 29, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Exercise and Chronic Pain.
Authors: Borisovskaya A, Chmelik E, Karnik A Abstract In this chapter, we describe the impact and etiology of chronic pain, the associated changes in the nervous system, and the mechanisms by which exercise may be able to affect and reverse these changes. Evidence for efficacy of exercise in different conditions associated with chronic pain is presented, with focus on chronic low back pain, fibromyalgia, osteoarthritis, rheumatoid arthritis, and migraines. While the efficacy of exercise and level of evidence supporting it vary in different diseases, exercise has direct and indirect benefits for most patients suffer...
Source: Advances in Experimental Medicine and Biology - April 29, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Comparative Effectiveness of Treatments for Chronic Low Back Pain
No abstract available (Source: Journal of Spinal Disorders and Techniques)
Source: Journal of Spinal Disorders and Techniques - April 29, 2020 Category: Surgery Tags: Letter to the Editor Source Type: research

Platelet-Rich Plasma Versus Corticosteroids in the Treatment of Chronic Plantar Fasciitis: A Systematic Review and Meta-analysis of Prospective Comparative Studies
The objective of this review was to compare platelet-rich plasma injection (PRP) and corticosteroids injection in the treatment of chronic plantar fasciitis. MEDLINE, PubMed, Web of Science, EMBASE, and the Cochrane library of clinical trials were searched in March 2019. Inclusion criteria were prospective comparative studies reporting functional scores or pain score with a minimum follow-up of 1 month. (Source: Journal of Foot and Ankle Surgery)
Source: Journal of Foot and Ankle Surgery - April 29, 2020 Category: Orthopaedics Authors: Nedal Alkhatib, Motasem Salameh, Abdulaziz F. Ahmed, Eslam Alkaramany, Ghalib Ahmed, Mohamed M. Mekhaimar, Jasim Alsaei Source Type: research

Agomelatine potentiates anti-nociceptive effects of morphine in a mice model for diabetic neuropathy: involvement of NMDA receptor subtype NR1 within the raphe nucleus and periaqueductal grey.
Discussion: The combination of agomelatine with morphine alone causes outlasting analgesic effects of repeated treatment, which can be interpreted as attenuated tolerance. Moreover, we also pointed out for the first time the modulatory effects of agomelatine on GluN1 expression in raphe nucleus and PAG after chronic morphine treatment.Abbreviations: Ca2+: Calcium; D2DR: Dopamine D2 receptor; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; GluN1: Glutamate ionotropic receptor N-methyl-D-aspartate type subunit-1; 5-HT: 5-hydroxytryptamine; i.p.: intraperitoneal injection; MPE: Maximal possible effect; MT: Melatonin; NMDA: N...
Source: Neurological Research - April 29, 2020 Category: Neurology Tags: Neurol Res Source Type: research

An uncommon cause of chronic abdominal pain and diarrhea.
We present the case of a 57-years-old male, with a history of 4-5 months of diffuse abdominal pain, watery diarrhoea due to this infection. The colonoscopy revealed a serpiginous ulcer in the cecum. The biopsy was positive for intestinal spirochaetosis. It is rare infection, more common among immunocompromised patients and HIV, with a faecal-oral transmission. Most cases are incidental findings in the endoscopic screening. In symptomatic patients the watery diarrhoea and non-specific abdominal pain are the most common symptoms. The macroscopic appearance on the colonoscopy is often normal or non-specific lesions can be ide...
Source: Revista Espanola de Enfermedades Digestivas - April 29, 2020 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

Laparoscopic Beger procedure for the treatment of chronic pancreatitis: a single-centre first experience
The Beger procedure is a common surgical option in the management of the unremitting abdominal pain of chronic pancreatitis (CP). As an organ-sparing surgery, it might be a better choice than pancreatoduodenec... (Source: BMC Surgery)
Source: BMC Surgery - April 29, 2020 Category: Surgery Authors: He Cai, Yunqiang Cai, Xin Wang and Bing Peng Tags: Case report Source Type: research

Pediatric chronic myeloid leukemia: A single-center experience
Conclusion: Pediatric CML in India is comparable with Western countries regarding epidemiological characteristic, clinical presentations, and tolerance of imatinib. As there is a paucity of universal literature regarding pediatric CML (especially data from Southeast Asian region), this article may fill up that space. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - April 29, 2020 Category: Cancer & Oncology Authors: Irappa Madabhavi Apurva Patel Gaurang Modi Asha Anand Harsha Panchal Sonia Parikh Source Type: research

From transformation to chronification of migraine: pathophysiological and clinical aspects
AbstractChronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8  days show typical migraine features. The process that describes the development from episodic migraine into chronic migraine is commonly referred to as migraine transformation or chronification. Ample studies have attempted to identify factors associated with migraine transformation from differen t perspectives. Understanding CM as a pathological brain state with trigeminovascular participation where biological changes occur, we have completed a comprehensive review on the clinical, epidemiolo...
Source: The Journal of Headache and Pain - April 29, 2020 Category: Neurology Source Type: research

A global real-world assessment of the impact on health-related quality of life and work productivity of migraine in patients with insufficient versus good response to triptan medication
AbstractBackgroundMigraine is a chronic, disabling neurological disease characterized by moderate-to-severe headache pain with other symptoms, including nausea, vomiting, and photophobia. Triptans, while generally effective, are insufficiently efficacious in 30 –40% of patients and poorly tolerated by or contraindicated in others. We assessed the impact of insufficient response to triptans on health-related quality of life (HRQoL) and work productivity in patients currently receiving any prescribed triptan formulation as their only acute migraine medicat ion.MethodsData were from the 2017 Adelphi Migraine Disease Spe...
Source: The Journal of Headache and Pain - April 29, 2020 Category: Neurology Source Type: research

Opioid Use in Urologic Practice
AbstractPurpose of ReviewThe opioid epidemic has become a major public health crisis over the last two decades. The opioid-related deaths and economic costs have increased dramatically since opioid analgesics started to be prescribed regularly to help control cancer- and non-cancer-related pain in the late twentieth century. As a result of the worsening opioid crisis, various guidelines and government regulations have recently been implemented to cope with this opioid problem as it affects all fields of medicine, urology included. Many conditions in urology involve chronic pain medication, including neurogenic bladder. Thi...
Source: Current Bladder Dysfunction Reports - April 29, 2020 Category: Urology & Nephrology Source Type: research

Pain Management in Thoracic Surgery
Thoracic surgery is considered one of the most painful surgical procedures performed. Pain is mediated via several mechanisms and is affected by the surgical approach as well as patient factors. Pain after thoracic surgery can be debilitating and lead to poor outcomes, such as respiratory complications, longer hospital stays, poor quality of life, and chronic post-thoracotomy pain syndrome. A multimodal approach to postoperative pain that combines systemic and regional anesthesia has been shown to be the most effective in optimizing analgesia in these patients. (Source: Thoracic Surgery Clinics)
Source: Thoracic Surgery Clinics - April 29, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Kyle Marshall, Keleigh McLaughlin Source Type: research

Acute coronary syndromes and acute heart failure: a diagnostic dilemma and high ‐risk combination. A statement from the Acute Heart Failure Committee of the Heart Failure Association of the European Society of Cardiology
AbstractAcute coronary syndrome is a precipitant of acute heart failure in a substantial proportion of cases, and the presence of both conditions is associated with a higher risk of short ‐term mortality compared to acute coronary syndrome alone. The diagnosis of acute coronary syndrome in the setting of acute heart failure can be challenging. Patients may present with atypical or absent chest pain, electrocardiograms can be confounded by pre‐existing abnormalities, and cardiac biomarkers are frequently elevated in patients with chronic or acute heart failure, independently of acute coronary syndrome. It is important t...
Source: European Journal of Heart Failure - April 29, 2020 Category: Cardiology Authors: Veli ‐Pekka Harjola, John Parissis, Johann Bauersachs, Hans‐Peter Brunner‐La Rocca, Hector Bueno, Jelena Čelutkienė, Ovidiu Chioncel, Andrew J.S. Coats, Sean P. Collins, Rudolf A. Boer, Gerasimos Filippatos, Etienne Gayat, Loreena Hill Tags: Position Paper Source Type: research

A Critical Overview of the Current Myofascial Pain Literature – January 2020
We are starting 2020 with 6 basic research studies, 9 reviews articles, 14 dry needling/injection studies and one manual therapy paper for a total of 30 new papers. Topics range from studies on mechanisms, inflammatory mediators in myofascial pain, fascia, screening, Platelet-rich plasma intramuscular injections, and temporal summation to clinical studies on patients with tension-type headache, chronic pelvic pain, knee osteoarthritis, plantar fasciitis, generalized musculoskeletal pain, neck pain, breast cancer, tendinopathies, thoracic outlet syndrome, and canine dry needling, among others. (Source: Journal of Bodywork a...
Source: Journal of Bodywork and Movement Therapies - April 29, 2020 Category: Physiotherapy Tags: Myofascial Pain and Treatment Source Type: research

The use of transcranial motor-evoked potentials, somatosensory-evoked potentials and free-run electromyography for proper placement of paddle leads in chronic pain
. (Source: British Journal of Neurosurgery)
Source: British Journal of Neurosurgery - April 29, 2020 Category: Neurosurgery Authors: Jos é F. Paz Mar ía del Mar Santiago Sanz Mar ía Victoria Paz-Domingo Mar ía Luisa Gandía-González Susana Santiago-P érez Jose Mar ía Roda Frade Source Type: research

Activation of the descending pain modulatory system using cuff pressure algometry: Back translation from man to rat
AbstractBackgroundDiffuse noxious inhibitory controls (DNIC) as measured in rat and conditioned pain modulation (CPM), the supposed psychophysical paradigm of DNIC measured in humans, are unique manifestations of an endogenous descending modulatory pathway that is activated by application of a noxious conditioning stimulus. The predictive value of the human CPM processing is crucial when deliberating the translational worth of the two phenomena.MethodsFor CPM or DNIC measurement, test and conditioning stimuli were delivered using a computer ‐controlled cuff algometry system or manual inflation of neonate blood pressure c...
Source: European Journal of Pain - April 29, 2020 Category: Anesthesiology Authors: TM Cummins, M Kucharczyk, T Graven ‐Nielsen, K Bannister Tags: ORIGINAL ARTICLE Source Type: research

Effects of Kinesio Taping and compression stockings on pain, edema, functional capacity and quality of life in patients with chronic venous disease: a randomized controlled trial.
Abstract OBJECTIVE: The aim of this study was to compare the effects of Kinesio Taping and compression stockings on pain, edema, functional capacity and quality of life in patients with chronic venous disease (CVD). DESIGN: This is a prospective, randomized, controlled, single-blind clinical trial. SETTING: The study was conducted in a physiotherapy and rehabilitation unit of a university hospital. SUBJECTS: A total of 62 patients with early-stage CVD were allocated to either an experimental group or a control group. INTERVENTIONS: Experimental group (n = 29) received Kinesio Tapi...
Source: Clinical Rehabilitation - April 29, 2020 Category: Rehabilitation Authors: Naci B, Ozyilmaz S, Aygutalp N, Demir R, Baltaci G, Yigit Z Tags: Clin Rehabil Source Type: research

Local Anesthetic Injection Resolves Movement Pain, Motor Dysfunction, and Pain Catastrophizing in Individuals With Chronic Achilles Tendinopathy, a Non-Randomized Clinical Trial.
CONCLUSION: People with Achilles tendinopathy had elevated pain psychological factors and motor dysfunction, but not signs of nociplastic pain with quantitative sensory testing. Removal of nociceptive input normalized movement-evoked pain and some indicators of altered central processing (motor dysfunction, pain catastrophizing), but not kinesiophobia. J Orthop Sports Phys Ther, Epub 29 Apr 2020. doi:10.2519/jospt.2020.9242. PMID: 32349638 [PubMed - as supplied by publisher] (Source: Physical Therapy)
Source: Physical Therapy - April 29, 2020 Category: Physiotherapy Authors: Chimenti RL, Hall MM, Dilger CP, Merriwether EN, Wilken JM, Sluka KA Tags: J Orthop Sports Phys Ther Source Type: research

Acute coronary syndromes and acute heart failure: a diagnostic dilemma and high ‐risk combination. A statement from the Acute Heart Failure Committee of the Heart Failure Association of the European Society of Cardiology
AbstractAcute coronary syndrome is a precipitant of acute heart failure in a substantial proportion of cases, and the presence of both conditions is associated with a higher risk of short ‐term mortality compared to acute coronary syndrome alone. The diagnosis of acute coronary syndrome in the setting of acute heart failure can be challenging. Patients may present with atypical or absent chest pain, electrocardiograms can be confounded by pre‐existing abnormalities, and cardiac biomarkers are frequently elevated in patients with chronic or acute heart failure, independently of acute coronary syndrome. It is important t...
Source: European Journal of Heart Failure - April 29, 2020 Category: Cardiology Authors: Veli ‐Pekka Harjola, John Parissis, Johann Bauersachs, Hans‐Peter Brunner‐La Rocca, Hector Bueno, Jelena Čelutkienė, Ovidiu Chioncel, Andrew J.S. Coats, Sean P. Collins, Rudolf A. Boer, Gerasimos Filippatos, Etienne Gayat, Loreena Hill Tags: Position Paper Source Type: research

Intralesional Triamcinolone May Not Be Beneficial for Treating Acute Hidradenitis Suppurativa Lesions: A Double-Blind, Randomized, Placebo-Controlled Trial
CONCLUSION No statistically significant difference was found between varying concentrations of triamcinolone and NS for the treatment of HS lesions. Steroid injections may be less effective for the management of acute HS than typically presumed. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - April 28, 2020 Category: Dermatology Tags: Original Article Source Type: research

Micropore Particle Technology Promotes Wound Healing, Whereas Polyhexamethylene Biguanide Causes Tissue Degeneration: A Case Report.
CONCLUSIONS: It is generally assumed that the cytotoxic properties of antiseptics seen in cell culture experiments do not occur on wounds. The present case shows these cytotoxic properties are expressed on wounds, and they do disrupt tissues and tissue regeneration. PMID: 32335523 [PubMed - in process] (Source: Wounds)
Source: Wounds - April 28, 2020 Category: General Medicine Tags: Wounds Source Type: research

Liposuction Treatment of a Subacute Morel-Lavall ée Lesion: A Case Report.
CONCLUSIONS: This case of MLL was diagnosed early and successfully treated with liposuction, resulting in an acceptable cosmetic outcome. It is the authors' hope that this case report will lead to earlier diagnosis and proper treatment of MLLs. PMID: 32335518 [PubMed - in process] (Source: Wounds)
Source: Wounds - April 28, 2020 Category: General Medicine Tags: Wounds Source Type: research

Sensors, Vol. 20, Pages 2491: ICT-Based Health Care Services for Individuals with Spinal Cord Injuries: A Feasibility Study
This study aims to verify the effectiveness of health care and management in the SCI population by providing ICT-based health care services. We visited eight individuals living with chronic SCI in the community, and provided ICT-based health management services. After using respiratory and urinary care devices with the provision of home visit occupational therapy, data acquisition was achieved and subsequently entered into a smart device. The entered information was readily accessible to the necessary clinicians and researchers. The clients were notified if there were any concerning results from the acquired data. Subseque...
Source: Sensors - April 28, 2020 Category: Biotechnology Authors: Wan-ho Jang Seung-bok Lee Dong-wan Kim Yun-hwan Lee Yun-jeong Uhm Seung-wan Yang Jeong-hyun Kim Jong-bae Kim Tags: Article Source Type: research

Unusual Manifestation of Chronic Lymphocytic Leukemia in the Hand
We report a case of a 62-year-old man, with a 4-year history of a subclinical CLL, presenting with chronic swelling and pain over the dorsal surface of the right hand, mimicking an infectious process. There was no clinical response to broad-spectrum antibiotics and topical corticosteroid therapy. Imaging was inconclusive. A tissue biopsy revealed a manifestation of the underlying leukemia. (Source: The Journal of Hand Surgery)
Source: The Journal of Hand Surgery - April 28, 2020 Category: Surgery Authors: Diogo Cruz, Thomas Wild, Ievgen Glavynskyi, Kristian Weissenberg, Steffen Frenzel, Axel Florsch ütz, Jochen Winter Tags: Case Repository Source Type: research

Effect of Different Exercise Training Intensities on Musculoskeletal and Neuropathic Pain in Inactive Individuals with Type 2 Diabetes – Preliminary Randomised Controlled Trial
The benefits of physical exercise for the prevention and management of type 2 diabetes are well established, including improved glucose control, cardiorespiratory fitness, muscular strength, muscle mass, and body composition [1]. In contrast, there is little knowledge on the specific effects of exercise training on chronic pain in this population [2]. This is despite growing evidence that people with type 2 diabetes are more likely to develop a range of rheumatological and musculoskeletal problems, and experience both widespread and neuropathic pain [3 –5]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 28, 2020 Category: Endocrinology Authors: Emily R. Cox, Trishan Gajanand, Nicola W. Burton, Jeff S. Coombes, Brooke K. Coombes Source Type: research

Fast and sustained healing of resistant corneal ulcers using corneal scrubbing and matrix regenerating therapy.
CONCLUSION: In this study, combined corneal scrubbing and matrix regenerating therapy (with or without bandage contact lens) led to a rapid healing and successful resolution of persisting corneal ulcers, including large and deep corneal ulcers. PMID: 32345041 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - April 28, 2020 Category: Opthalmology Authors: Lazreg S, Labetoulle M, Renault D, Baudouin C Tags: Eur J Ophthalmol Source Type: research

Anti- IL-6 therapies for neuromyelitis optica spectrum disorders: A systematic review of safety and efficacy.
CONCLUSIONS: The anti-Il-6 agents tocilizumab and satralizumab show promising results in active NMOSD. Further randomized, larger-scale trials are needed to better define the role of these agents in the growing arsenal of NMOSD treatments. PMID: 32348222 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 28, 2020 Category: Drugs & Pharmacology Authors: Lotan I, McGowan R, Levy M Tags: Curr Neuropharmacol Source Type: research

Cognitive impairment in chronic migraine: a cross-sectional study in a clinic-based sample
Conclusions: Cognitive impairment is prevalent in the CM population during their mildest possible pain and may be caused by a central sensitization. Timely preventive treatment of EM is warranted.Resumo O comprometimento cognitivo foi descrito em todas as fases de um ataque de enxaqueca, de maneira intermitente. Entretanto, a preval ência e o fenótipo desse comprometimento na enxaqueca crônica (EC) não foram estudados. Objetivos: O objetivo deste estudo foi avaliar a prevalência do déficit cognitivo objetivo em pacientes com EC e fatores subjacentes à sua etiologia. Méto...
Source: Arquivos de Neuro-Psiquiatria - April 27, 2020 Category: Neurology Source Type: research

A new electrochemical sensor for determination of fentanyl lethal drug by screen-printed carbon electrode modified with open-ended channels of Zn (II)-MOF
In this study, a simple electrochemical method for the determination of fentanyl in... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - April 27, 2020 Category: Chemistry Authors: Ebrahim Naghian Source Type: research

Motive Satisfaction in Chronic Pain Patients: Does It Improve in Multidisciplinary Inpatient Treatment and, if so, Does It Matter?
AbstractAccording to consistency theory, insufficient motive satisfaction (motivational incongruence) is associated with psychological distress and mental disorders. High levels of distress and comorbid psychological disorders are common in patients with chronic pain. The aim of the present study was to investigate the role of motivational incongruence in chronic pain patients and the association of incongruence change with symptom improvement. Inpatients with chronic pain in multimodal interdisciplinary treatment (n = 177) completed questionnaires measuring motivational incongruence, psychological distress, ...
Source: Journal of Clinical Psychology in Medical Settings - April 27, 2020 Category: Psychiatry & Psychology Source Type: research

Feline Chronic Pain and Osteoarthritis
This article reviews the current knowledge regarding osteoarthritis-related pain in cats as a structure in which to discuss the assessment of chronic pain in the research and clinical settings. The scientific evidence available for current and emerging drug therapies is described. The importance of environmental enrichment and positive emotions to reduce pain, stress, and anxiety as means to promote feline welfare and human-pet bond is discussed. (Source: Veterinary Clinics of North America: Small Animal Practice)
Source: Veterinary Clinics of North America: Small Animal Practice - April 27, 2020 Category: Veterinary Research Authors: Beatriz P. Monteiro Source Type: research

Pathologic Findings in Fallopian Tubes of Women with Chronic Pelvic Pain after Essure Placement
Pelvic pain has been associated with Essure, a permanent contraceptive implant. Here we describe histopathologic findings in long-term Essure users with chronic pelvic pain. We descriptively evaluated and compared histopathologic features of hysterectomy specimens removed for a primary diagnosis of chronic pelvic pain from women with (n=3) and without (n=3) prior placement of Essure coils (mean of 8.6 years prior). Interstitial fallopian tubes of Essure patients demonstrated fibrosis. Two cases had flattening of ampullary epithelial folds. (Source: Contraception)
Source: Contraception - April 27, 2020 Category: OBGYN Authors: Alexandra Rubin, Jie-Fu Chen, Ashley Veade, Ian S. Hagemann Source Type: research

Chronic pain 1 –5 years after heart transplantation—A nationwide cross‐sectional cohort study
AbstractAimTo provide a multidimensional assessment of self ‐reported chronic pain 1–5 years after heart transplantation and its relationship with self‐reported well‐being, fatigue, recovery, self‐efficacy and socio‐economic factors and to explore differences between heart recipients and a cohort of lung recipients.DesignThis multicentre, cross ‐sectional, cohort study is a part of the Swedish national Self‐management after thoracic transplantation study.MethodsSix questionnaires were distributed at the heart recipients yearly follow ‐up (1–5 years) at three Swedish university hospital...
Source: Nursing Open - April 27, 2020 Category: Nursing Authors: Marita Dalvindt, Annika Kisch, Shahab Nozohoor, Annette Lennerling, Anna Forsberg Tags: RESEARCH ARTICLE Source Type: research

Mud Therapy Combined with Core Exercise for Chronic Nonspecific Low Back Pain: A Pilot, Single-Blind, Randomized Controlled Trial.
Conclusion: Mud therapy combined with core exercise is effective in relieving pain and improving motor function in patients with chronic nonspecific LBP. Further research is needed to underpin these preliminary results. PMID: 32328139 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 26, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

IJERPH, Vol. 17, Pages 3005: New insights about Chronic Pelvic Pain Syndrome (CPPS)
Conclusions: The therapeutic interventions in CPPS cases should, consequently, follow a multidisciplinary approach (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - April 26, 2020 Category: Environmental Health Authors: Grinberg Sela Nissanholtz-Gannot Tags: Review Source Type: research

Peripheral input and phantom limb pain: a somatosensory event ‐related potential study
ConclusionsPeripheral input can modulate PLP but seems insufficient to cause PLP. These findings suggest the multifactorial complexity of PLP and different mechanisms for PLP and RLP. (Source: European Journal of Pain)
Source: European Journal of Pain - April 26, 2020 Category: Anesthesiology Authors: Hongcai Liu, Jamila Andoh, Yuanyuan Lyu, Christopher Milde, Simon Desch, Francesca Zidda, Martin Schmelz, Gabriel Curio, Herta Flor Tags: ORIGINAL ARTICLE Source Type: research

Effect of physical manipulation on the oral pharmacokinetic profile of Xtampza ® ER (oxycodone DETERx® formulation): A review of published studies.
Effect of physical manipulation on the oral pharmacokinetic profile of Xtampza® ER (oxycodone DETERx® formulation): A review of published studies. J Opioid Manag. 2020 Mar/Apr;16(2):127-139 Authors: Gudin J Abstract Opioids can be an effective treatment option for appropriate patients with chronic pain for whom nonpharmacological or nonopioid treatment does not provide adequate pain relief. However, extended-release (ER) opioid formulations, because of their high drug content, are attractive options for nonmedical use and abuse. Xtampza® ER (oxycodone DETERx®) capsules, an ER abuse-dete...
Source: Journal of Opioid Management - April 25, 2020 Category: Addiction Tags: J Opioid Manag Source Type: research

Successful use of buprenorphine-naloxone medication-assisted program to treat concurrent pain and opioid addiction after cancer therapy.
Authors: Moryl N, Filkins A, Griffo Y, Malhotra V, Jain RH, Frierson E, Inturrisi C Abstract Cancer pain is often treated with opioids, a therapeutic regimen that can become a challenge in patients with an opioid use disorder (OUD). While use of the buprenorphine-naloxone combination is an effective medication-assisted treatment (MAT) for OUD, its use in pain patients with OUD has been controversial due to concerns that co-administration of buprenorphine can reduce or block analge-sia and precipitate opioid withdrawal in those patients requiring full opioid agonists. Data on its use in cancer pain patients are lack...
Source: Journal of Opioid Management - April 25, 2020 Category: Addiction Tags: J Opioid Manag Source Type: research