Quality of Life in Patients With Chronic Limb-Threatening Ischemia Treated With Revascularization
CONCLUSIONS: Among patients with chronic limb-threatening ischemia deemed eligible for either Bypass or Endo, revascularization resulted in significant and clinically meaningful improvements in HRQoL. In patients with an available single-segment great saphenous vein for bypass, but not among those without one, Endo was statistically superior on some HRQoL measures; however, these differences were below the threshold of clinically meaningful difference.PMID:38597097 | DOI:10.1161/CIRCULATIONAHA.123.065277 (Source: Circulation)
Source: Circulation - April 10, 2024 Category: Cardiology Authors: Matthew T Menard Alik Farber Richard J Powell Kenneth Rosenfield Michael S Conte Taye H Hamza John A Kaufman Mark J Cziraky Mark A Creager Michael D Dake Michael R Jaff Diane Reid George Sopko Christopher J White Michael B Strong Max van Over Emiliano Chi Source Type: research
The clinical value of β-blockers in patients with stable angina
Curr Med Res Opin. 2024;40(sup1):33-41. doi: 10.1080/03007995.2024.2317443. Epub 2024 Apr 10.ABSTRACTStable angina, one manifestation of chronic coronary syndrome (CCS), is characterised by intermittent episodes of insufficient blood supply to the myocardium, provoking symptoms of myocardial ischaemia, particularly chest pain. These attacks usually occur during exercise or stress. Anti-ischaemic drugs are the mainstay of pharmacologic management of CCS with symptoms of angina. β-blockers reduce heart rate and myocardial contractility, thus reducing myocardial oxygen consumption. These drugs have been shown to ameliorate t...
Source: Current Medical Research and Opinion - April 10, 2024 Category: Research Authors: Paolo Palatini Jose R Faria-Neto Raul D Santos Source Type: research
GSE229735 Pyroptotic T-cell-derived active IL-16 has a driving function in endometriosis development
Contributors : Jinghe Zhang ; Haiming WeiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEndometriosis is a common, chronic inflammatory condition that frequently results in pain and infertility and is estimated to affect 6 –10% of women of reproductive age. However, the mechanisms underlying the induction of inflammation in endometriosis remain unclear. Here, we identified that ectopic endometrial T-cell-derived active interleukin (IL)-16 acts as an inflammation-driving cytokine in endometriosis. Furthermore, we fou nd that in ectopic endometrial T cells, the activation of IL-16 ...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Circular RNA-GRIN2B Suppresses Neuropathic Pain by Targeting the NF- κB/SLICK Pathway
AbstractThe role of circular RNAs (circRNAs) in neuropathic pain is linked to the fundamental physiological mechanisms involved. However, the exact function of circRNAs in the context of neuropathic pain is still not fully understood. The functional impact of circGRIN2B on the excitability of dorsal root ganglion (DRG) neurons was investigated using siRNA or overexpression technology in conjunction with fluorescence in situ hybridization and whole-cell patch-clamp technology. The therapeutic efficacy of circGRIN2B in treating neuropathic pain was confirmed by assessing the pain threshold in a chronic constrictive injury (C...
Source: NeuroMolecular Medicine - April 10, 2024 Category: Neurology Source Type: research
Acute, Chronic, and Everyday Physical Pain in Borderline Personality Disorder
AbstractPurpose of ReviewPhysical pain is an underrecognized area of dysregulation among those with borderline personality disorder (BPD). Disturbances are observed within the experience of acute, chronic, and everyday physical pain experiences for people with BPD. We aimed to synthesize research findings on multiple areas of dysregulation in BPD in order to highlight potential mechanisms underlying the association between BPD and physical pain dysregulation.Recent FindingsPotential biological mechanisms include altered neural responses to painful stimuli within cognitive-affective regions of the brain, as well as potentia...
Source: Current Psychiatry Reports - April 10, 2024 Category: Psychiatry Source Type: research
Oral Delta-9-Tetrahydrocannabinol (THC) Increases Parasympathetic Activity and Supraspinal Conditioned Pain Modulation in Chronic Neuropathic Pain Male Patients: A Crossover, Double-Blind, Placebo-Controlled Trial
ConclusionsTHC shifts the autonomic balance towards increased parasympathetic tone and improves inhibitory pain mechanisms in chronic pain. The increase in vagal tone correlates with connectivity changes in higher-order regulatory brain regions, suggesting THC exerts top-down effects. These changes may reflect a normalizing effect of THC on multiple domains of supraspinal pain dysregulation.Clinical Trial Registry NumberNCT02560545. (Source: CNS Drugs)
Source: CNS Drugs - April 10, 2024 Category: Neurology Source Type: research
A Systematic Review of Chronic Pain Management Interventions Among Veterans of Recent Wars and Armed Conflicts
To identify chronic pain management strategies aimed to reduce pain intensity and enhance functional outcomes in veterans of wars and armed conflict. (Source: Pain Management Nursing)
Source: Pain Management Nursing - April 10, 2024 Category: Nursing Authors: Rital Lakshman, Emily Tomlinson, Tracey Bucknall Tags: Original Research Source Type: research
The influence of fascial manipulation on shoulder range of motion, pain, and function in individuals with chronic shoulder pain
A prevalent musculoskeletal condition that has a substantial socioeconomic impact and causes considerable morbidity is chronic shoulder pain (CSP). CSP may result from a dysfunction of the upper quarter region's (UQR) myofascial continuum (MC), which is connected by deep fascia. Fascial Manipulation ® (FM), proposed by Luigi Stecco, involves deep kneading performed at specific points on the deep fascia. FM is considered to reinstate the gliding of the fascial layers, thus may aid in the reduction of pain and improvement of shoulder function. (Source: Journal of Bodywork and Movement Therapies)
Source: Journal of Bodywork and Movement Therapies - April 10, 2024 Category: Physiotherapy Authors: Shruti Poojari, Neha C. Kamani, G. Prabu Raja Source Type: research
Experiences of patients with advanced cancer coping with chronic pain: a qualitative analysis
To gain insight into the perceptions, and beliefs of patients with advanced cancer coping with chronic pain and to identify their attitudes and demands on pain management. (Source: BMC Palliative Care)
Source: BMC Palliative Care - April 10, 2024 Category: Palliative Care Authors: Wanting Xia, Meijun Ou, Yongyi Chen, Furong Chen, Mengyao Yan, Zhirui Xiao and Xianghua Xu Tags: Research Source Type: research
Surgical bypass of superior and inferior mesenteric arteries with Dacron graft in a patient with acute on chronic mesenteric ischaemia with atherosclerotic complete occlusion of the infrarenal aorta
AbstractA 67-year-old male presented to us with symptoms of postprandial abdominal pain for the last 3 months and was not able to take meals for the last month. The computed tomography (CT) angiogram showed complete occlusion in the coeliac artery (CA), superior mesenteric artery (SMA) and inferior mesenteric artery (IMA) with complete occlusion of infrarenal aorta and bilateral iliac arteries. Whi le waiting for elective surgical mesenteric bypass, patient suddenly developed signs of peritonitis for which emergency surgery was done using a Dacron bifurcated graft 12 × 6 mm size. Inflow was taken from the supra coe...
Source: Indian Journal of Thoracic and Cardiovascular Surgery - April 10, 2024 Category: Cardiovascular & Thoracic Surgery Source Type: research
Examining the role of structural and functional social network characteristics in the context of chronic pain: An ego-centered network design
The well-being and functioning of individuals with chronic pain (CP) varies significantly. Social factors, such as social integration, may help explain this differential impact. Specifically, structural (network size, density) as well as functional (perceived social support, conflict) social network characteristics may play a role. However, it is not yet clear whether and how these variables are associated with each other. Objectives were to examine: (1) both social network characteristics in individuals with primary and secondary CP, (2) the association between structural network characteristics and mental distress, and f...
Source: The Journal of Pain - April 10, 2024 Category: Materials Science Authors: Mait é Van Alboom, Fleur Baert, Sónia F. Bernardes, Lesley Verhofstadt, Piet Bracke, Mingshan Jia, Katarzyna Musial, Bogdan Gabrys, Liesbet Goubert Source Type: research
Booster treatments in interdisciplinary multimodal pain therapy : Preparing structural and process parameters for the implementation of cross-sectoral booster treatments
In conclusion, the authors outline how the development of these parameters will be planned as an expert consensus with the participation of interested institutions and the inclusion of the patient perspective and offer opportunities for participation in this process.PMID:38592523 | DOI:10.1007/s00482-024-00807-z (Source: Schmerz)
Source: Schmerz - April 9, 2024 Category: Anesthesiology Authors: Karolin Teichm üller Benjamin Sch önbach Dirk Boujong Andreas B öger Rainer Sabatowski R üdiger Scharnagel Source Type: research
Targeting connexins: possible game changer in managing neuropathic pain?
Trends Mol Med. 2024 Apr 8:S1471-4914(24)00064-9. doi: 10.1016/j.molmed.2024.03.009. Online ahead of print.ABSTRACTNeuropathic pain is a chronic debilitating condition caused by nerve injury or a variety of diseases. At the core of neuropathic pain lies the aberrant neuronal excitability in the peripheral and/or central nervous system (PNS and CNS). Enhanced connexin expression and abnormal activation of connexin-assembled gap junctional channels are prominent in neuropathic pain along with reactive gliosis, contributing to neuronal hypersensitivity and hyperexcitability. In this review, we delve into the current understan...
Source: Trends in Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Yixun Su Alexei Verkhratsky Chenju Yi Source Type: research
A Review of the Current Status of Anesthetic Management of Patients with Rheumatoid Arthritis
This article aims to review the current status of anesthetic management of patients with rheumatoid arthritis.PMID:38590091 | DOI:10.12659/MSM.943829 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 9, 2024 Category: Research Authors: Pawe ł Radkowski Maciej Szewczyk Klaudia Sztaba Mariusz K ęska Source Type: research
Booster treatments in interdisciplinary multimodal pain therapy : Preparing structural and process parameters for the implementation of cross-sectoral booster treatments
In conclusion, the authors outline how the development of these parameters will be planned as an expert consensus with the participation of interested institutions and the inclusion of the patient perspective and offer opportunities for participation in this process.PMID:38592523 | DOI:10.1007/s00482-024-00807-z (Source: Schmerz)
Source: Schmerz - April 9, 2024 Category: Anesthesiology Authors: Karolin Teichm üller Benjamin Sch önbach Dirk Boujong Andreas B öger Rainer Sabatowski R üdiger Scharnagel Source Type: research
