Effects of the Characteristics and Duration of Chronic Pain on Psychosomatic Function in the Community-Dwelling Elderly Population.
This study aimed to evaluate the characteristics of CP in the community-dwelling elderly population and to investigate the effects of different periods of CP on cognitive and psychological functions. A total of 187 community-dwelling elderly people met the inclusion criteria and were included in this cross-sectional study. The survey items included demographic data (age and gender), pain-related questionnaires, psychological and cognitive functions, and sleep status. The duration of CP was investigated using three categories: no pain and pain for ≤1 year and ≥1 year. A logistic regression analysis was performed to id...
Source: Pain Research and Management - April 25, 2020 Category: Anesthesiology Authors: Hida M, Nakamura M, Imaoka M, Nakao H, Tasaki F, Omizu T, Takeda M, Ohnishi T, Wada C Tags: Pain Res Manag Source Type: research

Persistent exit-site infection in peritoneal dialysis - An unrecognized window to abdominal viscera.
Authors: Domingos AT, Malho Guedes A, Mendes FB, Vidinha J, Bernardo I, Neves PL Abstract Exit-site (ES) infection is a common complication in peritoneal dialysis (PD). Pseudomonas spp. is particularly difficult to treat, and catheter removal should be considered in persistent infections. The authors present a chronic ES infection resistant to directed antibiotic therapy in which catheter salvage was not possible. Removal was very difficult due to the presence of white sponge-like tissue with petrous consistency surrounding the catheter, all the way into the peritoneum. Histology revealed well-differentiated adenoc...
Source: Peritoneal Dialysis International - April 25, 2020 Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research

Sustained response to onabotulinumtoxin A in patients with chronic migraine: real-life data
ConclusionsAbout two thirds of patients who gain ≥50% response to BT-A within the third cycle of treatment maintain this positive response over time. More recent onset of CM and more headache-free days at baseline are associated with sustained response. We suggest not to delay preventive treatment of CM with BT-A, in order to increase the likeli hood to achieve sustained clinical response. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - April 25, 2020 Category: Neurology Source Type: research

Effects of a patient-centered program including the cumulative-complexity model in women with chronic pelvic pain: a randomized controlled trial
Chronic pelvic pain (CPP) is a complex pain syndrome defined as noncyclical pain of at least 6 months ’ duration, located in the pelvis, lower back, buttocks and/or the anterior abdominal wall that affects 14% – 24% of women worldwide [1]. CPP may involve gynecologic, musculoskeletal, gastroenterologic and urologic systems, with significant presence of psychosocial and somatic comorbidities [2]. Women diagnosed with CPP frequently report a negative impact on quality of life, physical functioning, and the ability to work or perform activities of daily living [3]. (Source: Maturitas)
Source: Maturitas - April 25, 2020 Category: Primary Care Authors: M ª José Ariza-Mateos, Irene Cabrera-Martos, Laura López-López, Janet Rodríguez-Torres, Irene Torres-Sánchez, Marie Carmen Valenza Source Type: research

Modifications to the PREEMPT Protocol for OnabotulinumtoxinA Injections for Chronic Migraine in Clinical Practice.
CONCLUSIONS: The wide inter- and intra-personal variations in BoNT-A injections for chronic migraine prevention seen in this survey raise concerns about the standardization of the procedure and suggest that an advisory protocol containing more evidence and discussion of the reasoning behind the recommendations might be more helpful than the current prescriptive protocol. PMID: 32335918 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - April 25, 2020 Category: Neurology Authors: Begasse de Dhaem O, Gharedaghi MH, Rizzoli P Tags: Headache Source Type: research

Prevalence and Risk Factors for Opioid-Induced Constipation in an Older National Veteran Cohort.
Conclusions: There were several novel covariates found that are seen in the all-cause chronic constipation literature but have not been reported for opioid-induced constipation. Some are modifiable covariates, particularly medication coadministration, which may assist clinicians and researchers in risk stratification efforts when initiating opioid medications. The integration of CMS data supports the robustness of the analysis and may be of interest in the elderly population warranting future examination. PMID: 32318129 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - April 24, 2020 Category: Anesthesiology Authors: FitzHenry F, Eden SK, Denton J, Cao H, Cao A, Reeves R, Chen G, Gobbel G, Wells N, Matheny ME Tags: Pain Res Manag Source Type: research

Sex and Gender are Not the Same: Why Identity Is Important for People Living with HIV and Chronic Pain
(Source: Journal of Pain Research)
Source: Journal of Pain Research - April 24, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Photobiomodulation therapy increases functional capacity of patients with chronic kidney failure: randomized controlled trial
AbstractPhotobiomodulation (PBM) has been used in different populations as a strategy to attenuate muscle fatigue and improve exercise performance. Recent findings demonstrated that a single session with specific PBM doses during hemodialysis (HD) increased the upper limb muscle strength of chronic kidney failure (CKF) patients. Now, the primary objective of this study was to evaluate the chronic effect of PBM on the functional capacity of this population. Secondarily, we aimed at investigating the effects of PBM on the patients ’ strength, muscle thickness and echogenicity, perception of pain, fatigue, and quality o...
Source: Lasers in Medical Science - April 24, 2020 Category: Laser Surgery Source Type: research

In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo
Volume 12, Issue 1, January-December 2020 . (Source: mAbs)
Source: mAbs - April 24, 2020 Category: Biomedical Science Authors: Edwina Stack Sheridan McMurray Gordon McMurray Jason Wade Melissa Clark Gareth Young Kim Marquette Sadhana Jain Kerry Kelleher Ting Chen Qingcong Lin Laird Bloom Laura Lin William Finlay Rie Suzuki Orla Cunningham Source Type: research

Quantitation of Gait and Stance Alterations Due to Monosodium Iodoacetate-induced Knee Osteoarthritis in Yucatan Swine.
Abstract Knee osteoarthritis is one of the most common causes of chronic pain worldwide, and several animal models have been developedto investigate disease mechanisms and treatments to combat associated morbidities. Here we describe a novel method for assessment of locomotor pain behavior in Yucatan swine. We used monosodium iodoacetate (MIA) to induce osteoarthritis in the hindlimb knee, and then conducted live observation, quantitative gait analysis, and quantitative weight-bearing stance analysis. We used these methods to test the hypothesis that locomotor pain behaviors after osteoarthritis induction would be...
Source: Comparative Medicine - April 24, 2020 Category: Zoology Authors: LaVallee KT, Maus TP, Stock JD, Stalder KJ, Karriker LA, Murthy NS, Kanwar R, Beutler AS, Unger MD Tags: Comp Med Source Type: research

[Chronic chikungunya arthritis].
This article describes the case of a 48-year-old female traveller returning from Bangladesh who presented with persisting pain and joint swelling due to chikungunya virus infection, which had persisted for months. Typical symptoms are a high fever and musculoskeletal disorders, which can last for months up to years. The chronic inflammatory form is treated similarly to those recommended for other chronic inflammatory joint diseases. Due to the increasing prevalence of the virus and its vectors as well as the unbroken travel activity, an increase in imported cases in Europe and establishment of the pathogen in sou...
Source: Zeitschrift fur Rheumatologie - April 24, 2020 Category: Rheumatology Authors: Trawinski H, Krasselt M, Lübbert C Tags: Z Rheumatol Source Type: research

Systematic review of clinical practice guidelines for colorectal and anal cancer: the extent of recommendations for managing long-term symptoms and functional impairments
ConclusionsFew clinical practice guidelines include recommendations for managing long-term symptoms and functioning impairments. It is unclear if this is due to limited evidence or absence of management strategies and interventions. Clear recommendations for managing long-term symptoms and functioning to help health professionals in supporting colorectal and anal cancer survivors are needed. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 23, 2020 Category: Cancer & Oncology Source Type: research

Managing patients with chronic pain during the COVID-19 outbreak: considerations for the rapid introduction of remotely supported (eHealth) pain management services
No abstract available (Source: Pain)
Source: Pain - April 23, 2020 Category: Anesthesiology Tags: Topical Review Source Type: research

Exploring the neural correlates of touch and pain in women with provoked vestibulodynia
Group differences in touch and pain thresholds—and their neural correlates—were studied in women with provoked vestibulodynia (PVD; N = 15), a common subtype of vulvodynia (chronic vulvar pain), and pain-free control women (N = 15). Results from quantitative sensory testing and self-report measures indicated that, as compared with control participants, women with PVD exhibited allodynia (ie, pain in response to a normally nonpainful stimulus) and hyperalgesia (ie, an increased response to a normally painful stimulus) at vulvar and nonvulvar sites. In addition, brain imaging analyses demonstrated reduced differe...
Source: Pain - April 23, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Nociceptive input after peripheral nerve injury results in cognitive impairment and alterations in primary afferent physiology in rats
In this study, we hypothesized that persistent activation of peripheral nociceptors after injury would lead to the development of a chronic pain state that impairs attention-related behavior and results in changes in peripheral neuron phenotypes. Attentional performance was measured in rats using the 5-choice serial reaction time titration variant to determine the initial impact of partial L5 spinal nerve ligation and the effect of persistent nociceptor activation on the resolution of injury. The changes in peripheral neuronal sensibilities and phenotypes were determined in sensory afferents using electrophysiologic signat...
Source: Pain - April 23, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Impact of opioid dose escalation on pain intensity: a retrospective cohort study
Prescribers are often confronted with the decision to escalate opioid doses to achieve adequate analgesia. Understanding the impact of dose escalation on pain intensity is warranted. Using a retrospective cohort study design, Veterans with chronic pain and chronic opioid therapy were identified. Opioid dose escalators (>20% increase in average morphine milligram equivalent daily dose) were compared with dose maintainers (±20% change in average morphine milligram equivalent daily dose) assessed over 2 consecutive 6-month windows. Pain intensity was measured by the Numeric Rating Scale. The primary analyses used li...
Source: Pain - April 23, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Efficacy and safety of linaclotide for opioid-induced constipation in patients with chronic noncancer pain syndromes from a phase 2 randomized study
Constipation is the most common adverse event (AE) of opioid therapy. This multicenter, phase 2 study evaluated the efficacy and safety of linaclotide in treating opioid-induced constipation (OIC) in patients with chronic noncancer pain syndromes (NCT02270983). Adults with OIC ( (Source: Pain)
Source: Pain - April 23, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

The dichotomous role of epiregulin in pain
It has recently been shown that epidermal growth factor receptor (EGFR) contributes to the pathogenesis of pain. We scanned genetic markers within genes coding for receptors of the EGFR family (EGFR, ERBB2, ERBB3, and ERBB4) and their ligands (AREG, BTC, EGF, EPGN, EREG, HBEGF, MUC4, NRG1, NRG2, NRG3, NRG4, and TGFA) for association with self-reported pain intensity in patients with chronic facial pain who participated in the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) cohort. We found that only epiregulin (EREG) was associated with pain. The strongest effect was observed for a minor allele at rs683...
Source: Pain - April 23, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

A “dyadic dance”: pain catastrophizing moderates the daily relationships between parent mood and protective responses and child chronic pain
This study used a microlongitudinal design to examine the daily relationships between parent mood and protective responses and child chronic pain. We also examined the moderating roles of child and parent pain catastrophizing to determine how the affective-motivational context may alter the influence of parent factors. Participants included 95 youth with idiopathic chronic pain (Mage = 14.08; 71.6% female) and their parents. At baseline, parents and youth reported on their catastrophic thinking about child pain. For 7 consecutive days, parents completed daily assessments of their mood and protective responses, while youth ...
Source: Pain - April 23, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

An unbiased and efficient assessment of excitability of sensory neurons for analgesic drug discovery
Alleviating chronic pain is challenging, due to lack of drugs that effectively inhibit nociceptors without off-target effects on motor or central neurons. Dorsal root ganglia (DRG) contain nociceptive and non-nociceptive neurons. Drug screening on cultured DRG neurons, rather than cell lines, allows for the identification of drugs most potent on nociceptors with no effects on non-nociceptors (as a proxy for unwanted side effects on central nervous system and motor neurons). However, screening using DRG neurons is currently a low-throughput process, and there is a need for assays to speed this process for analgesic drug dis...
Source: Pain - April 23, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Cannabis for Symptom Management in Older Adults.
This article provides an overview of the evidence on the risks and benefits of using medical cannabis for the indications of chronic pain, cancer-related pain, cancer cachexia, dementia, and Alzheimer's disease. Currently, there is insufficient evidence to determine the effectiveness and safety of cannabinoids for most reviewed indications, with the exception of chronic pain. Future research is required before palliative care clinicians can make evidence-based decisions on the integration of medical cannabis as adjunct therapies. PMID: 32312410 [PubMed - in process] (Source: The Medical Clinics of North America)
Source: The Medical Clinics of North America - April 23, 2020 Category: General Medicine Authors: Levy C, Galenbeck E, Magid K Tags: Med Clin North Am Source Type: research

Pain intensity and pressure pain thresholds after a light dynamic physical load in patients with chronic neck-shoulder pain
To investigate the development of pain intensity and pressure pain thresholds during and 24  h after a light dynamic physical load among patients with chronic neck-shoulder pain. (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - April 23, 2020 Category: Orthopaedics Authors: A. Grimby-Ekman, C. Ahlstrand, B. Gerdle, B. Larsson and H. Sand én Tags: Research article Source Type: research

Percutaneous Bioelectric Current Stimulation for Chronic Cluster Headache & ndash; A Possible Transformative Approach to Cluster Headache
(Source: Journal of Pain Research)
Source: Journal of Pain Research - April 23, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Evaluation of complications following stock replacement of the temporomandibular joint performed between the years 2006 and 2015: a retrospective study
ConclusionsAs with any surgical procedure, TMJR can have complications. The results of this study demonstrate that the most common post-operative complication was continued pain. Chronic pain after TMJR was more common in patients with a preoperative diagnosis of degenerative joint disease. Also, the incidence of post-operative TMJR pain increased with the duration of symptoms prior to TMJR, leading to a question of the best timing for TMJR. (Source: Oral and Maxillofacial Surgery)
Source: Oral and Maxillofacial Surgery - April 23, 2020 Category: ENT & OMF Source Type: research

Combination of Filtered Bone Marrow Aspirate and Biomimetic Scaffold for the Treatment of Knee Osteochondral Lesions: Cellular and Early Clinical Results of a Single Centre Case Series
AbstractBackground:Osteochondral injury is a very common orthopaedic pathology, mainly affecting young, active population, with limited current treatment options. Herein we are presenting cellular and early clinical data of a patient series treated for chronic osteochondral lesions in the knee with a filter-based intra-operative bone marrow aspirate (BMA) separation device.Methods:Fifteen patients with chronic knee osteochondral lesions (60% females, 19 –59 years) were included in this prospective case series. Filtered BMA (f-BMA), containing mesenchymal stem/stromal cells (MSCs), was combined with a biomimetic colla...
Source: Tissue Engineering and Regenerative Medicine - April 23, 2020 Category: Biotechnology Source Type: research

The Pathways and Processes Underlying Spinal Transmission of Low Back Pain: Observations From Dorsal Root Ganglion Stimulation Treatment
BackgroundDorsal root ganglion stimulation (DRG ‐S) is a novel approach to treat chronic pain. Lead placement at L2 has been reported to be an effective treatment for axial low back pain (LBP) primarily of discogenic etiology. We have recently shown, in a diverse cohort including cases of multilevel instrumentation following extensive prior bac k surgeries, that DRG‐S lead placement at T12 is another promising target. Local effects at the T12 DRG, alone, are insufficient to explain these results.Materials and MethodsWe performed a literature review to explore the mechanisms of LBP relief with T12 DRG ‐S.FindingsBranc...
Source: Neuromodulation: Technology at the Neural Interface - April 23, 2020 Category: Biotechnology Authors: Kenneth B. Chapman, Pauline S. Groenen, Kris C. Vissers, Noud van Helmond, Michael D. Stanton ‐Hicks Tags: Review Article Source Type: research

Lumbosacral immobilization following glucocorticoid intradiscal injection in patients with chronic low back pain and active discopathy: A feasibility study.
CONCLUSIONS: We found high rates of refusal and early withdrawal of the lumbosacral immobilization using a pantaloon cast following GC IDI in people with nonspecific cLBP and active discopathy. PMID: 32310158 [PubMed - as supplied by publisher] (Source: Journal of Back and Musculoskeletal Rehabilitation)
Source: Journal of Back and Musculoskeletal Rehabilitation - April 22, 2020 Category: Orthopaedics Tags: J Back Musculoskelet Rehabil Source Type: research

The effects of dry needling on pain relief and functional balance in patients with sub-chronic low back pain.
Authors: Loizidis T, Nikodelis T, Bakas E, Kollias I Abstract BACKGROUND: Pain relief is important both for the movement of patients suffering from low back pain and the quality of life. Dry needling is effective on myofascial trigger points but its effect on the area of pain and the functional balance is not fully known. OBJECTIVE: To examine the immediate effect of dry needling on pain and functional balance of patients suffering from low back pain. METHODS: Twenty five patients with sub-chronic low back pain were randomly divided into two groups: the intervention or control group. Needles were used for t...
Source: Journal of Back and Musculoskeletal Rehabilitation - April 22, 2020 Category: Orthopaedics Tags: J Back Musculoskelet Rehabil Source Type: research

Oral Gabapentinoids and Nerve Blocks for the Treatment of Chronic Ocular Pain
Conclusions: Approaches used to treat chronic pain outside the eye can be applied to ocular pain that is not responsive to traditional therapies. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - April 22, 2020 Category: Opthalmology Tags: Article Source Type: research

Virtual reality distraction induces hypoalgesia in patients with chronic low back pain: a randomized controlled trial
Attentional distraction from pain has been shown to be largely ineffective for obtaining a hypoalgesic effect in patients with chronic pain when compared to a control condition. It has been hypothesized that t... (Source: Journal of NeuroEngineering and Rehabilitation)
Source: Journal of NeuroEngineering and Rehabilitation - April 22, 2020 Category: Rehabilitation Authors: Thomas Matheve, Katleen Bogaerts and Annick Timmermans Tags: Research Source Type: research

Interdisciplinary Laparoscopic Implantation of Neuromodulation Leads to the Sacral Plexus for Therapy of Chronic Pelvic Pain and Neurogenic Bladder Dysfunctions
ObjectiveThe aim of this study was to report on the use of laparoscopic implantation of leads on the branches of the sacral plexus for neuromodulation in the treatment of chronic pelvic pain (CPP) in a multidisciplinary setting with the help of electrophysiological neuromonitoring.Materials and MethodsBetween 2012 and 2019, six female patients complaining of chronic pain and bladder and bowel dysfunctions underwent laparoscopic exposure and nerve identification with the help of electrophysiological neuromonitoring. A lead was placed laparoscopically in direct contact with the affected nerve. Pain intensity (numerous rankin...
Source: Neuromodulation: Technology at the Neural Interface - April 22, 2020 Category: Biotechnology Authors: Malgorzata Kolodziej, Eberhard Uhl, Frank Schwarm, Jasmin Nagl, Rainer Sch ürg, Ivo Meinhold‐Heerlein, Hans‐Rudolf Tinneberg Tags: Basic Research Source Type: research

Effects of Tourniquets in the Development of Pain States: a Novel Clinical Pilot Study and Review of Utilization of Tissue Oximetry to Measure Neural Ischemia
AbstractPurpose of ReviewApproximately 20% of patients undergoing surgery develop persistent lower extremity pain following total knee arthroplasty. Animal studies have confirmed that prolonged tourniquet time increases the risk of endoneural ischemia and can mediate or modulate the development of chronic pain. The use of Near InfraRed Spectroscopy (NIRS) adjacent to nerve tissue, previously described as ONG has been shown to detect early neural compromise and has demonstrated clinical utility in carpal tunnel diagnosis.Recent FindingsIn this pilot study, we recruited 10 healthy adult volunteers to undergo oxyneurography (...
Source: Current Pain and Headache Reports - April 22, 2020 Category: Neurology Source Type: research

Carpal tunnel sonography
AbstractCarpal tunnel syndrome (CTS) is the most frequent entrapment neuropathy of peripheral nerves, with an incidence of 1 –3 patients in 1000. CTS typically occurs between 45 and 60 years of age, and it is more frequent in women than in men. The main cause of CTS is chronic compression of the median nerve and ischemic suffering secondary to increased pressure in the carpal tunnel. There are many possible causes of C TS, which can be differentiated into idiopathic causes, which include most cases, and secondary causes. Classical CTS diagnosis is based on the patient’s clinical examination and electrophys...
Source: Journal of Ultrasound - April 22, 2020 Category: Radiology Source Type: research

Dissociation between reduced pain and arterial blood pressure following epidural spinal cord stimulation in patients with chronic pain: A retrospective study
AbstractPurposeAcute pain and resting arterial blood pressure (BP) are positively correlated in patients with chronic pain. However, it remains unclear whether treatment for chronic pain reduces BP. Therefore, in a retrospective study design, we tested the hypothesis that implantation of an epidural spinal cord stimulator (SCS) device to treat chronic pain would significantly reduce clinic pain ratings and BP and that these reductions would be significantly correlated.MethodsPain ratings and BP in medical records were collected before and after surgical implantation of a SCS device at the University of Iowa Hospitals and C...
Source: Clinical Autonomic Research - April 22, 2020 Category: Research Source Type: research

Examination and characterisation of burst spinal cord stimulation on cerebrospinal fluid cellular and protein constituents in patient responders with chronic neuropathic pain - A Pilot Study
This study examines the dynamic biological changes of CSF at a cellular and proteome level after Burst-SCS. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 22, 2020 Category: Allergy & Immunology Authors: Jonathan Royds, Melissa J. Conroy, Margaret R. Dunne, Hilary Cassidy, David Matallanas, Joanne Lysaght, Connail McCrory Source Type: research

Might chronic opioid use impact sleep-disordered breathing and vice versa?
Journal of Clinical Sleep Medicine, Ahead of Print. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - April 22, 2020 Category: Sleep Medicine Authors: Jeremy E. OrrMark S. WallaceAtul Malhotra1Division of Pulmonary, Critical Care, and Sleep Medicine, UC San Diego, La Jolla, California2Division of Pain Medicine, UC San Diego, La Jolla, California Source Type: research

Transcutaneous electrical nerve stimulation (TENS) for chronic pain: the opportunity to begin again.
PMID: 32323312 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 22, 2020 Category: General Medicine Authors: Travers MJ, O'Connell NE, Tugwell P, Eccleston C, Gibson W Tags: Cochrane Database Syst Rev Source Type: research

Risk Factors for the Development of Post-Traumatic Headache Attributed to Traumatic Brain Injury: A Systematic Review.
CONCLUSIONS: We found that there is little evidence for any risk factors involved in the development of acute PTH, whereas no study had assessed risk factors for the development of persistent PTH. Further studies are warranted and should be powered to examine possible risk factors for the development of PTH. Rigorous methodology and standardized monitoring should be prioritized to support high-quality research and validate potential findings. PMID: 32320055 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - April 22, 2020 Category: Neurology Authors: Andersen AM, Ashina H, Iljazi A, Al-Khazali HM, Chaudhry B, Ashina M, Ashina S, Schytz HW Tags: Headache Source Type: research

Family reflections: raising kids with chronic pain.
PMID: 32320991 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - April 22, 2020 Category: Pediatrics Authors: Young JKL Tags: Pediatr Res Source Type: research

Aiming at ideal therapeutics- MOPr/DOPr or MOPr-DOPr heteromer-targeting ligand.
CONCLUSION: I found that most of those ligands possesses potent antinociceptive activity (as much as or higher than that of morphine) with reduced side effects such as tolerance. In addition, some of them are also able to reduce or prevent physiological withdrawal symptoms observed under chronic opioid use. Importantly, there are increasing number of evidences that show changes in heteromer expression in various pathological animal models and these strongly argue for targeting heteromers for the development the next generation of pain medication in the near future. PMID: 32324516 [PubMed - as supplied by publisher] (S...
Source: Current Topics in Medicinal Chemistry - April 22, 2020 Category: Chemistry Authors: Fujita W Tags: Curr Top Med Chem Source Type: research

[Validity of the Mainz Pain Staging System for chronic low back pain : A  cross-sectional analysis of inpatient multidisciplinary rehabilitation].
CONCLUSION: These results confirm the validity and clinical relevance of the MPSS. Moreover, the psychological burden of the patients increased with the stage of pain. Therefore, psychological treatments are required that are tailored to patients' needs. Thus, measurement of the MPSS and psychological diagnostic assessments are recommended. PMID: 32322971 [PubMed - as supplied by publisher] (Source: Schmerz)
Source: Schmerz - April 22, 2020 Category: Anesthesiology Authors: Köpnick A, Hampel P Tags: Schmerz Source Type: research

α-Bisabolol suppresses the inflammatory response and ECM catabolism in advanced glycation end products-treated chondrocytes and attenuates murine osteoarthritis.
α-Bisabolol suppresses the inflammatory response and ECM catabolism in advanced glycation end products-treated chondrocytes and attenuates murine osteoarthritis. Int Immunopharmacol. 2020 Apr 22;84:106530 Authors: Xu C, Sheng S, Dou H, Chen J, Zhou K, Lin Y, Yang H Abstract As a chronic musculoskeletal degeneration disease, osteoarthritis (OA) clinically manifests as joint pain, stiffness and a limited range of movement. OA has affected the life quality of at least one-tenth of the population but lacks satisfactory treatments. α-Bisabolol (BISA) is a small oily sesquiterpene alcohol widely...
Source: International Immunopharmacology - April 22, 2020 Category: Allergy & Immunology Authors: Xu C, Sheng S, Dou H, Chen J, Zhou K, Lin Y, Yang H Tags: Int Immunopharmacol Source Type: research

Pain Diagnosis, Pain Coping, and Function in Individuals with Chronic Musculoskeletal Pain
(Source: Journal of Pain Research)
Source: Journal of Pain Research - April 21, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Nontraditional and Home-Based Self-management Interventions in Cancer Patients With Pain: A Mixed-Method Systematic Review
One or 2 decades ago, oncologists focused on only cancer treatments or acute care related to cancer. Since cancer care is considered as long-term cares, cancer patients require self-management (SM) ability or skill to manage their symptoms and daily cares. This mixed-method review is to evaluate quantitative and qualitative studies, which were conducted using non-traditional SM interventions for cancer pain based. This review also explores the process of SM in the chronic care model (CCM). PubMed, CINAHL, Scopus, and Wiley were used from 2011 to 2018. A total of 16 quantitative and 2 qualitative studies were included for t...
Source: Holistic Nursing Practice - April 21, 2020 Category: Nursing Tags: FEATURES Source Type: research

A Review of Nonanesthetic Uses of Ketamine.
Authors: Pribish A, Wood N, Kalava A Abstract Ketamine, a nonselective NMDA receptor antagonist, is used widely in medicine as an anesthetic agent. However, ketamine's mechanisms of action lead to widespread physiological effects, some of which are now coming to the forefront of research for the treatment of diverse medical disorders. This paper aims at reviewing recent data on key nonanesthetic uses of ketamine in the current literature. MEDLINE, CINAHL, and Google Scholar databases were queried to find articles related to ketamine in the treatment of depression, pain syndromes including acute pain, chronic pain, ...
Source: Anesthesiology Research and Practice - April 21, 2020 Category: Anesthesiology Tags: Anesthesiol Res Pract Source Type: research

Topical Analgesic and Local Anesthetic Agents for Pain Associated with Chronic Leg Ulcers: A Systematic Review
CONCLUSIONS Lidocaine/prilocaine cream and ibuprofen foam are effective agents for reducing wound-related pain associated with chronic leg ulcers. Effective use of topical agents could reduce the need for systemic pain relief agents, mitigating potential adverse effects, while giving clinicians another treatment option to manage wound-related pain associated with chronic leg ulcers. (Source: Advances in Skin and Wound Care)
Source: Advances in Skin and Wound Care - April 21, 2020 Category: Dermatology Tags: CLINICAL MANAGEMENT EXTRA Source Type: research

Topical Analgesic and Local Anesthetic Agents for Pain Associated with Chronic Leg Ulcers: A Systematic Review
No abstract available (Source: Advances in Skin and Wound Care)
Source: Advances in Skin and Wound Care - April 21, 2020 Category: Dermatology Tags: CE TEST Source Type: research

The Enduring Mystery of Pain in a Social Context
Chronic pain has become a health epidemic, with one in five U.S. adults suffering from chronic pain and an estimated annual cost of $560 billion in medical care, lost productivity, or disability services [1]. Understanding pain has never been more crucial. Our current biopsychosocial understanding of pain explicitly recognizes the important role of the social dimension in explaining pain  [2], and recently, it was proposed to update the official definition of pain to explicitly mention that pain encompasses not only sensory, emotional, and cognitive components but also social ones [3]. (Source: Journal of Adolescent Health)
Source: Journal of Adolescent Health - April 21, 2020 Category: Child Development Authors: Kai Karos Tags: Editorial Source Type: research

Magnetic resonance imaging of impingement and friction syndromes around the knee
AbstractThe knee is a complex joint with its function dependent on a combination of osseous and soft tissue structures. Alteration in the relationship of these tissues, due to either acute or chronic repetitive injury with possible underlying congenital predisposing factors, can result in impingement between the structures resulting in pain, particularly on activity. The purpose of this article is to provide a comprehensive review of the MRI features of various impingement syndromes around the knee. (Source: Skeletal Radiology)
Source: Skeletal Radiology - April 21, 2020 Category: Radiology Source Type: research

Treatment of C-section diverticula with hysteroscopic resection in women without childbearing intention: a retrospective cohort study
Diverticulum, one of the long-term sequelae of cesarean section, can cause abnormal uterine bleeding, dysmenorrhea and chronic pelvic pain. Hysteroscopic resection of diverticula is thought to reduce abnormal ... (Source: BMC Women's Health)
Source: BMC Women's Health - April 21, 2020 Category: OBGYN Authors: Hui Shi, Jingyan He, Yunhe Gao, Shuang Qin, Jiaying Fan, Qing Xiao, Kuanrong Li and Huiying Liang Tags: Research article Source Type: research