Opioid analgesia: recent developments
Purpose of review Opioids are potent drugs for the treatment of severe pain, but they are burdened by detrimental side-effects, such as respiratory depression, addiction, sedation and constipation. Their clinical application is undisputed in acute (e.g. perioperative) and cancer pain, but their use in chronic nonmalignant pain has met increasing scrutiny and has contributed to the opioid crisis. Thus, novel analgesics with reduced side-effects are badly needed. Recent findings Current research topics include enkephalinase inhibitors, allosteric and multivalent ligands, biased opioid receptor signaling and selective ac...
Source: Current Opinion in Supportive and Palliative Care - May 5, 2020 Category: Palliative Care Tags: PAIN: NON-MALIGNANT DISEASES: Edited by Anthony H. Dickenson and Kirsty Bannister Source Type: research

Percutaneous CT-guided lumbar trans-facet pedicle screw fixation in lumbar microinstability syndrome: feasibility of a novel approach
ConclusionTFF seems to be a powerful technique for lumbar spine stabilization in patients with chronic mechanical LBP related to lumbar MI. CT-guided technique is fast, precise, and safe and can be performed in simple analgo-sedation. (Source: Neuroradiology)
Source: Neuroradiology - May 5, 2020 Category: Radiology Source Type: research

Partnering with Family Caregivers in Pain Management
Family caregivers play a pivotal role in supporting the efforts of healthcare providers for individuals with chronic diseases or disabling conditions (Chi& Demiris, 2017). According to the National Alliance for Caregiving, in 2015 approximately 43.5 million adult family caregivers in the United States had provided unpaid care to family members in the previous 12  months (National Alliance for Caregiving& AARP Public Policy Institute, 2015). As the population of aging Americans with chronic conditions continues to increase, the demand for family caregiver assistance will further rise (Chi& Demiris, 2017). (...
Source: Pain Management Nursing - May 5, 2020 Category: Nursing Authors: Elaine L. Miller, Dania Abu-Alhaija Tags: Editorial Source Type: research

A Novel, Reliable Protocol to Objectively Assess Scar Stiffness Using Shear Wave Elastography
The aim of this research was to investigate the use of shear wave elastography as a novel tool to quantify and visualize scar stiffness after a burn. Increased scar stiffness is indicative of pathologic scarring which is associated with persistent pain, chronic itch and restricted range of movement. Fifty-five participants with a total of 96 scars and 69 contralateral normal skin sites were evaluated. A unique protocol was developed to enable imaging of the raised and uneven burn scars. Intra-rater and inter-rater reliability was excellent (intra-class correlation coefficient>0.97), and test –retest reliability wa...
Source: Ultrasound in Medicine and Biology - May 5, 2020 Category: Radiology Authors: Helen DeJong, Steven Abbott, Marilyn Zelesco, Katrina Spilsbury, Lisa Martin, Rowan Sanderson, Melanie Ziman, Brendan Kennedy, Fiona M. Wood Tags: Original Contribution Source Type: research

Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain [Neuroscience]
Chronic pain is a highly prevalent disease with poorly understood pathophysiology. In particular, the brain mechanisms mediating the transition from acute to chronic pain remain largely unknown. Here, we identify a subcortical signature of back pain. Specifically, subacute back pain patients who are at risk for developing chronic pain exhibit... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - May 5, 2020 Category: Science Authors: Meena M. Makary, Pablo Polosecki, Guillermo A. Cecchi, Ivan E. DeAraujo, Daniel S. Barron, Todd R. Constable, Peter G. Whang, Donna A. Thomas, Hani Mowafi, Dana M. Small, Paul Geha Tags: Biological Sciences Source Type: research

Correlations Between Family History of Psychiatric Illnesses and Outcomes of Spinal Cord Stimulation
ConclusionsSubjects with PFH may experience less improvement in disability following SCS as compared to subjects without PFH. They may take longer to achieve the same outcomes, including pain relief and decrease in pain rumination. Our findings show that improvements in the PFH cohort are equivalent to that of the no PFH cohort on all measures except ODI at 12 ‐month follow‐up. Thus obtaining a detailed PFH prior to performing SCS is important in order to implement pre‐operative coping training for PFH patients, rather than exclusion from SCS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 5, 2020 Category: Biotechnology Authors: Breanna L. Sheldon, Olga Khazen, Paul J. Feustel, Guy Gechtman, Gavril Rosoklija, Shrey Patel, Marisa DiMarzio, Cheyanne Bridger, Rachel Dentinger, Julia Slyer, Julie G. Pilitsis Tags: Clinical Research Source Type: research

Social support facilitates physical activity by reducing pain.
Conclusions One pathway through which social support impacts physical activity is by reducing peoples' pain. Increasing and strengthening peoples' social support networks may confer benefits for their physical activity levels, including among those whose physical activity is limited by pain. Statement of contribution What is already known on this subject? Social support can have a positive effect on health behaviours, including physical activity. There is somewhat inconsistent evidence for a positive direct relationship between social support and physical activity. Pain can be a barrier to physical activity, but may be att...
Source: British Journal of Health Psychology - May 5, 2020 Category: Psychiatry & Psychology Authors: Stevens M, Cruwys T, Murray K Tags: Br J Health Psychol Source Type: research

The Benefits of T'ai Chi for Older Adults with Chronic Back Pain: A Qualitative Study
The Journal of Alternative and Complementary Medicine, Ahead of Print. (Source: The Journal of Alternative and Complementary Medicine)
Source: The Journal of Alternative and Complementary Medicine - May 5, 2020 Category: Complementary Medicine Authors: Tamsin L. Lee Karen J. Sherman Rene J. Hawkes Elizabeth A. Phelan Judith A. Turner Source Type: research

Effects of pain neuroscience education and dry needling for the management of patients with chronic myofascial neck pain: a randomized clinical trial.
z-Carnero J Abstract OBJECTIVES: The aim of this study was to observe the medium-term effects on pain, disability, and psychological factors of a combination of myofascial trigger point (MTrP) dry needling (DN) with pain neuroscience education (PNE) versus DN alone versus control care as usual (CUC) in patients with chronic neck pain. METHODS: A total of 60 patients were randomly selected in a Spanish National Health Service Public Hospital and divided into three groups: 6 sessions of DN with 3 sessions of PNE (TrPDN + PNE group, n = 21), 6 sessions of DN alone (TrPDN group, n&thin...
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - May 5, 2020 Category: Complementary Medicine Authors: Valiente-Castrillo P, Martín-Pintado-Zugasti A, Calvo-Lobo C, Beltran-Alacreu H, Fernández-Carnero J Tags: Acupunct Med Source Type: research

Chronic postoperative inguinal pain: A narrative review.
García MJ Abstract Inguinodynia or chronic postoperative inguinal pain is a growing problem between patients who undergo surgical repair of an inguinal hernia. The change in results measurement proposed by many authors towards Patient Reported Outcome Measurement has underlined the importance of chronic postoperative inguinal pain, because of the great limitations in everyday life and the huge socioeconomic impact that it causes. In this article a narrative review of the available literature in PUBMED, EMBASE and Cochrane Library is performed and the most relevant aspects about epidemiology, etiology preve...
Source: Cirugia eEspanola - May 5, 2020 Category: Surgery Authors: Medina Velázquez R, Marchena Gómez J, Luque García MJ Tags: Cir Esp Source Type: research

Myricitrin regulates proliferation, apoptosis and inflammation of chondrocytes treated with IL-1 β.
Myricitrin regulates proliferation, apoptosis and inflammation of chondrocytes treated with IL-1β. Cell Mol Biol (Noisy-le-grand). 2020 Apr 20;66(1):65-69 Authors: Sun T, Xue JB, Zhou YL, Wang XF Abstract Osteoarthritis (OA) is a clinical disease which seriously affects the quality of life of sufferers. Although the pathogenesis of OA has not been fully unraveled, it is may be due to increased levels of pro-inflammatory cytokines, activation of inflammation-related signaling pathways, and degradation of extracellular matrix. Osteoarthritis is characterized by chronic joint pain, swelling, stiffnes...
Source: Cellular and Molecular Biology - May 4, 2020 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

Improving care of chronic pain patients with spinal cord stimulator therapy amidst the opioid epidemic
AbstractThe US government and other key stakeholders including professional medical bodies have amended recommendations in recent years to emphasize using no opioids or the lowest effective dose of opioids needed for treatment of chronic pain. However, there remains an unmet need for pain treatments that can both relieve the pain of patients and reduce the doses of opioids they require. The Center for Medicare and Medicaid Services (CMS) is currently considering such treatments through the SUPPORT ACT and has recently conferred with the Health and Human Services (HHS) Inter-agency Pain Management Task Force to consider suc...
Source: Neurological Sciences - May 4, 2020 Category: Neurology Source Type: research

Direct and indirect costs of cluster headache: a prospective analysis in a tertiary level headache centre
AbstractBackgroundCluster headache (CH) is the most frequent trigemino-autonomic cephalgia. CH can manifest as episodic (ECH) or chronic cluster headache (CCH) causing significant burden of disease and requiring attack therapy and prophylactic treatment. The few data available on the economic burden of CH come from retrospective studies based on questionnaires, population surveys and medical insurance claims database. Although all these studies showed an important economic burden, they provided different estimates depending on variability of CH awareness and management, healthcare systems, available therapies and use of tr...
Source: The Journal of Headache and Pain - May 4, 2020 Category: Neurology Source Type: research

Chronic intractable lumbosacral radicular pain, is there a remedy? Pulsed radiofrequency treatment and volumetric modifications of the lumbar dorsal root ganglia
AbstractPurposeEvaluation of clinical and radiological effects of the therapeutic outcome of CT-guided pulsed radiofrequency (PRF) treatment adjacent to the lumbar dorsal root ganglion (DRG) for patients with chronic intractable lumbosacral radicular pain in a single-center prospective longitudinal study in order to evaluate predictive factors of safety and therapeutic success.Materials and methodsThirty patients, from 2016 to 2018, were enrolled (age: 42 –80 aa, 66.7% men and 33.3% females) with low back pain, lumbosciatalgia and/or lumbocruralgia, resistant to previous medical and physical treatments for a period not 
Source: La Radiologia Medica - May 4, 2020 Category: Radiology Source Type: research

Alcohol Use Disorder and the Persistence/Recurrence of Major Depression.
This study aims to determine the role of alcohol use disorder and other potential risk factors on persistence/recurrence of major depression in a Canadian population sample. METHODS: Data were drawn from the National Population Health Survey (1994/1995 to 2010/2011), a prospective epidemiologic survey of individuals 12 years and older, living in 10 Canadian provinces (N = 17,276). Participants were reinterviewed every 2 years for 9 cycles. This study population was a cohort of individuals who at baseline met the diagnosis of a major depressive episode (MDE) in the previous 12 months (n = 908). After the 6-year (cycle ...
Source: Canadian Journal of Psychiatry - May 4, 2020 Category: Psychiatry Authors: Onaemo VN, Fawehinmi TO, D'Arcy C Tags: Can J Psychiatry Source Type: research

Novel therapeutic approaches and targets for treatment of Suppurativa Hidradenitis.
CONCLUSION: Target therapy has revolutionized the treatment of moderate to severe HS, basing on the inhibition of specific molecular or cellular targets, directly involved in the pathogenesis of the condition. PMID: 32368973 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - May 4, 2020 Category: Biotechnology Authors: Giuffrida R, Cannavò SP, Coppola M, Guarneri C Tags: Curr Pharm Biotechnol Source Type: research

[Pain management in sickle cell disease].
e M Abstract Sickle cell disease is associated with numerous symptoms and complications. Acute painful crisis is the most characteristic manifestation of the disease. In addition, many patients report chronic pain. As both acute and chronic pain severely diminish quality of life, adequate pain management is crucial. Recommendations for the treatment of acute painful crises are based on the World Health Organization analgesic ladder, which has been developed for cancer-related pain. Chronic pain can be treated with basic long-acting opioids and on-demand short-acting opioids. If patients show signs of neuropathic p...
Source: Schmerz - May 4, 2020 Category: Anesthesiology Authors: Rasche T, Emmert D, Seidel H, Sellin J, Conrad R, Mücke M Tags: Schmerz Source Type: research

Family history influences the effectiveness of home-exercise in older people with chronic low back pain: a secondary analysis of a randomised controlled trial
To investigate whether a family history of LBP influences patient outcomes and treatment effects following home-exercises in older people with chronic LBP. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - May 3, 2020 Category: Rehabilitation Authors: Joshua R. Zadro, Debra Shirley, Tom IL. Nilsen, Paul J. Mork, Paulo H. Ferreira Source Type: research

The role of immune and epithelial stem cells in inflammatory bowel disease therapy.
CONCLUSION: Both, hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are able to restore damaged tissue and regulate the immune system. Autologous HSCs transplantation eliminates autoreactive cells and replace them with new T-cells resulting a long-time remission. Whereas MSCs transplantation is effective therapy in one of the major complications of IBD, perianal fistulas. PMID: 32364073 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - May 3, 2020 Category: Drugs & Pharmacology Authors: Agata B, Sylwia Z, Hans HI, Maciej S Tags: Curr Drug Targets Source Type: research

Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in the Netherlands.
CONCLUSIONS: This study on dry eye confirmed but also refuted many risk factors from smaller epidemiological studies, and discovered numerous new risk factors in multiple etiological categories. The finding that dry eye symptoms are particularly common in young adults is concerning, and warrants further study. PMID: 32376389 [PubMed - as supplied by publisher] (Source: The Ocular Surface)
Source: The Ocular Surface - May 3, 2020 Category: Opthalmology Authors: Vehof J, Snieder H, Jansonius N, Hammond CJ Tags: Ocul Surf Source Type: research

Fecal Calprotectin as a Useful Non-Invasive Screening Marker for Eosinophilic Gastrointestinal Disorder in Korean Children.
CONCLUSION: FCal is a useful and reliable noninvasive marker for differentiating EoGID from functional abdominal pain disorder in Korean children with chronic gastrointestinal symptoms when optimal cutoffs are applied. PMID: 32356420 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - May 2, 2020 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Interactive Association Between Mechanical and Sensorimotor Aspects of Cervical Extensor Muscles: Implications for Chronic Neck Pain.
Authors: Ghamkhar L, Amiri Arimi S, Kahlaee AH Abstract While proprioceptive functioning of the cervical extensor muscles has been proposed to be associated with chronic neck pain (NP), the mechanism by which such impairment might contribute to NP is not clear. The aim of this cross-sectional study was to investigate the relevance of proprioception, extensor muscles size, and endurance to chronic NP. A total of 60 participants with (n = 30) or without (n = 30) chronic NP participated in this cross-sectional study. Joint repositioning error (JRE), ultrasonographic parameters of the cervical extensors, and clinical e...
Source: Journal of Applied Biomechanics - May 2, 2020 Category: Sports Medicine Tags: J Appl Biomech Source Type: research

Prevalence of Burnout Syndrome Among Students of Health Care Colleges and its Correlation to Musculoskeletal Disorders in Saudi Arabia
Conclusions:Burnout, as well as MSDs, are prevalent among students of health care colleges. Burnout seems to be a risk factor for MSDs. Social media campaigns andawareness campaigns about burnout should be promoted.Keywords:Burnout, musculoskeletal pain, prevalence, psychological, students (Source: International Journal of Preventive Medicine)
Source: International Journal of Preventive Medicine - May 2, 2020 Category: International Medicine & Public Health Source Type: research

Infected Schmorl ’s node: a case report
Schmorls node (SN) are mostly asymptomatic and incidental findings on MRI. However, sometimes they present like acute onset low back pain or acute exacerbation of chronic back pain after minor trauma. (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - May 2, 2020 Category: Orthopaedics Authors: Hyeun Sung Kim, Harshavardhan Dilip Raorane, Sagar Bhupendra Sharma, Pang Hung Wu and Il-Tae Jang Tags: Case report Source Type: research

Assessing wrist pain: a simple guide.
This article looks at the bony and neurovascular anatomy of the wrist joint and describes a simple guide to clinical assessment of wrist pathology, highlighting the awareness of red flag signs, which would warrant an immediate referral for secondary care input. PMID: 32468936 [PubMed - in process] (Source: British Journal of Hospital Medicine)
Source: British Journal of Hospital Medicine - May 2, 2020 Category: Internal Medicine Authors: Prasad G, Bhalli MJ Tags: Br J Hosp Med (Lond) Source Type: research

Molecular Aspects of Regional Pain Syndrome.
Abstract The purpose of this review is to summarize the pathophysiology of complex regional pain syndrome (CRPS), the underlying molecular mechanisms, and potential treatment options for its management. CRPS is a multifactorial pain condition. CRPS is characterized by prolonged or excessive pain and changes in skin color and temperature, and/or swelling in the affected area, and is generally caused by stimuli that lead to tissue damage. An inflammatory response involving various cytokines and autoantibodies is generated in response to acute trauma/stress. Chronic phase pathophysiology is more complex, involving th...
Source: Pain Research and Management - May 1, 2020 Category: Anesthesiology Authors: Baronio M, Sadia H, Paolacci S, Prestamburgo D, Miotti D, Guardamagna VA, Natalini G, Sullivan SGB, Bertelli M Tags: Pain Res Manag Source Type: research

Tapentadol Prolonged Release for Severe Chronic Osteoarthritis Pain in the Elderly-A Subgroup Analysis of Routine Clinical Practice Data.
Conclusion: Tapentadol PR provided effective and well-tolerated treatment of severe chronic OA pain for elderly patients in routine clinical practice. The favorable tolerability profile in particular suggests tapentadol PR as a treatment option before classical strong opioids are considered. PMID: 32351639 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - May 1, 2020 Category: Anesthesiology Authors: Schwittay A, Sohns M, Heckes B, Elling C Tags: Pain Res Manag Source Type: research

Standard Correction of Vision Worsens EMG Activity of Pericranial Muscles in Chronic TMD Subjects.
The objective of this work was to evaluate the effects of standard vision correction on EMG in subjects suffering from TMD compared with application of the same vision treatments to non-TMD subjects. 40 subjects were enrolled in this study. The test group included 20 myopic subjects and also included patients with TMD. The control group included 20 healthy myopic subjects. All of the participants underwent a complete ocular examination and a sEMG analysis. The results showed that TMD subjects with vision disorders that are corrected with standard glasses present EMG values that are significantly higher than those presented...
Source: Pain Research and Management - May 1, 2020 Category: Anesthesiology Authors: Monaco A, Ortu E, Giannoni M, D'Andrea P, Cattaneo R, Mummolo A, Pietropaoli D Tags: Pain Res Manag Source Type: research

The Relationship of Sleep Duration with Ethnicity and Chronic Disease in a Canadian General Population Cohort.
Abstract Study Objectives: Sleep duration is an important marker of sleep quality and overall sleep health. Both too little and too much sleep are associated with poorer health outcomes. We hypothesized that ethnicity-specific differences in sleep duration exist. Methods: This cross-sectional study utilized questionnaire data from the Ontario Health Study (OHS), a multi-ethnic population-based cohort of Canadian adult residents aged 18 to 99 years, who provided medical, socio-demographic, and sleep information. Generalised linear models were used to investigate the association of sleep duration with ethnicity...
Source: Pain Physician - May 1, 2020 Category: Anesthesiology Authors: Singh M, Hall KA, Reynolds A, Palmer LJ, Mukherjee S Tags: Nat Sci Sleep Source Type: research

Bilateral stellate ganglion block for migraine: A case report
Rationale: Migraine is a recurrent, disabling neurovascular headache disorder. The patient's quality of life can be severely impaired by migraine attacks. Stellate ganglion block (SGB) can be used to relieve pain in the head, neck, and upper extremities. In the present cases, we performed SGB in 2 patients with migraine that responds poorly to drugs. Patient concerns: Patients 1 and 2 suffered from chronic, bilateral pulsating headache, accompanied by nausea and vomiting. Patient 1 presented with headache of 8 on the visual analog scale (VAS), and 37 on the migraine disability assessment (MIDAS). Patient 2 reported he...
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Traumatic Brain Injury and Opioid Overdose Among Post-9/11 Veterans With Long-Term Opioid Treatment of Chronic Pain
Conclusion: TBI status, especially in the context of comorbid conditions, should be considered in clinical decisions regarding long-term use of opioids in patients with chronic pain. (Source: The Journal of Head Trauma Rehabilitation)
Source: The Journal of Head Trauma Rehabilitation - May 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Occurrence of lymphoplasmacytic lymphoma in a chronic myeloid leukemia patient following long-term treatment with tyrosine kinase inhibitors: A case report
Conclusion: Herein, for the first time, we describe a patient who developed LPL as a secondary malignancy after administration of TKIs for the treatment of CML. Our observations indicate the importance of awareness of this secondary malignancy that can develop in CML patients treated with TKIs. (Source: Medicine)
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Bilateral radial collateral ligament rupture in a shoemaker: A case report and brief literature review
Conclusion: Compared to acute RCL rupture of the index MCP joint, occupation may play an important role in the diagnosis of chronic RCL rupture of the index MCP joint. Our report will provide more diagnostic and treatment experience to deal with this type of injury. (Source: Medicine)
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Prevalence of postmastectomy pain syndrome and associated risk factors: A large single-institution cohort study
Postmastectomy pain syndrome (PMPS) is a frequent complication of breast surgery, and is considered a chronic neuropathic pain in the side of surgery which persists more than 3 months. We conducted a retrospective analysis of the largest reported cohort to investigate the prevalence of PMPS and to analyze its associated risk factors as well as the influence on quality of life (QoL). Two thousand thirty-three surgically-treated female patients diagnosed between 2012 and 2017 with early-stage breast cancer were asked to complete a questionnaire survey about their current chronic neuropathic pain problems and quality of life....
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

A clinical study on safety and efficacy of Naesohwajung-tang on functional dyspepsia
Discussion: This trial will evaluate the safety and efficacy of NHT as a treatment of FD. The results of this trial will not only verify whether NHT improves FD symptoms and gastric myoelectrical activity, but also clarify those correlations. Trial registration number: CRIS KCT0003405. (Source: Medicine)
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Personalized electro-acupuncture versus auricular-acupuncture comparative effectiveness (PEACE): A protocol of a randomized controlled trial for chronic musculoskeletal pain in cancer survivors
We describe the design of a 3-arm, parallel, single-center, multisite randomized controlled trial that investigates EA and BFA versus usual-care wait-list control (WLC) for chronic musculoskeletal pain among 360 patients with diverse cancer types across various stages. The primary aim is to compare effects of EA and BFA versus WLC on pain, physical function, and co-morbid symptoms. The secondary aim is to examine the interaction between patient outcome expectancy and acupuncture modality (EA vs BFA) on pain reduction. The tertiary aim is to evaluate the association between genetic polymorphisms and responses to acupuncture...
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Vocal cord involvement and hoarseness in a patient with Behcets disease: A rare case report
Rationale: Behcets disease (BD) is a type of chronic systemic vasculitis that typically manifests as a mucocutaneous disease with orogenital ulcers, skin damage, and uveitis. The clinical diagnosis is often difficult because of the diversity of organs that may be involved and lack of specific pathological diagnosis. Patient concerns: A 26-year-old woman presented as a nearly 2-week history of hoarseness with throat pain. Diagnoses: In the present case, Fiber laryngoscopy showed multiple ulcers involving the epiglottic tubercle, bilateral false vocal cord, middle area of the left vocal cord, and full length of the r...
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Impact of herbs and dietary supplements in patients with fibromyalgia: A protocol for a systematic review and meta-analysis of randomized controlled trials
Conclusion: The findings may provide a framework for future research and clinic practice in FM management. PROSPERO registration number: CRD42020149941 (Source: Medicine)
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Isokinetic back training is more effective than core stabilization training on pain intensity and sports performances in football players with chronic low back pain: A randomized controlled trial
Conclusion: This study suggests that training through IKT improves pain intensity and sports performances than CST in university football players with chronic LBP. (Source: Medicine)
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Lipid rafts in glial cells: role in neuroinflammation and pain processing [Thematic Reviews]
Activation of microglia and astrocytes secondary to inflammatory processes contributes to the development and perpetuation of pain with a neuropathic phenotype. This pain state presents as a chronic debilitating condition and affects a large population of patients with conditions like rheumatoid arthritis and diabetes, or after surgery, trauma, or chemotherapy. Here, we review the regulation of lipid rafts in glial cells and the role they play as a key component of neuroinflammatory sensitization of central pain signaling pathways. In this context, we introduce the concept of an inflammaraft (i-raft), enlarged lipid rafts ...
Source: The Journal of Lipid Research - May 1, 2020 Category: Lipidology Authors: Miller, Y. I., Navia-Pelaez, J. M., Corr, M., Yaksh, T. L. Tags: Thematic Reviews Source Type: research

MKP1 in the medial prefrontal cortex modulates chronic neuropathic pain via regulation of p38 and JNK1/2
. (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - May 1, 2020 Category: Neuroscience Authors: Yiling Qian Zhiyong Wang Siqi Zhou Weinan Zhao Cui Yin Junli Cao Zhiping Wang Yanqiang Li Source Type: research

Blunted Pain Modulation Response to Induced Stress in Women with Fibromyalgia with and without Posttraumatic Stress Disorder Comorbidity: New Evidence of Hypo-Reactivity to Stress in Fibromyalgia?
o Pérez JL, González Gutierrez JL Abstract There is evidence regarding the presence of alterations in both the stress response and the endogenous pain modulation systems of people with fibromyalgia (FM). However, research on pain modulation under induced stress on FM patients is scarce and contradictory. The present study analyzes stress-induced changes in pain and intolerance thresholds among FM patients, examining the possible existence of differences linked to PTSD comorbidity and gaining insights into the role of cardiovascular reactivity. Eighteen women diagnosed with FM and comorbid PTSD (FM&th...
Source: Behavioral Medicine - May 1, 2020 Category: Psychiatry Authors: López-López A, Matías-Pompa B, Fernández-Carnero J, Gil-Martínez A, Alonso-Fernández M, Alonso Pérez JL, González Gutierrez JL Tags: Behav Med Source Type: research

Symptom Management Among Cancer Survivors: Randomized Pilot Intervention Trial of Heart Rate Variability Biofeedback.
ke MA Abstract Chronic cancer-related symptoms (stress, fatigue, pain, depression, insomnia) may be linked with sympathetic nervous system over-activation and autonomic imbalance. Decreased heart rate variability (HRV) is an indicator of autonomic dysregulation that is commonly observed among cancer survivors. HRV biofeedback (HRVB) training induces HRV coherence, which maximizes HRV and facilitates autonomic and cardiorespiratory homeostasis. This randomized, wait-list-controlled, pilot intervention trial tested the hypothesis that HRVB can improve HRV coherence and alleviate cancer-related symptoms. The interven...
Source: Applied Psychophysiology and Biofeedback - May 1, 2020 Category: Psychiatry & Psychology Authors: Burch JB, Ginsberg JP, McLain AC, Franco R, Stokes S, Susko K, Hendry W, Crowley E, Christ A, Hanna J, Anderson A, Hébert JR, O'Rourke MA Tags: Appl Psychophysiol Biofeedback Source Type: research

Efficacy of acupressure for chronic low back pain: A systematic review.
CONCLUSION: Acupressure is a feasible, effective, safe, low cost nonpharmacologic method to treat CLBP. PMID: 32379678 [PubMed - as supplied by publisher] (Source: Complementary Therapies in Clinical Practice)
Source: Complementary Therapies in Clinical Practice - May 1, 2020 Category: Complementary Medicine Authors: Godley E, Smith MA Tags: Complement Ther Clin Pract Source Type: research

Efficacy and safety of moxibustion for chronic low back pain: A systematic review and meta-analysis of randomized controlled trials.
Abstract INTRODUCTION: To systematically review and meta-analyze the efficacy of moxibustion in treating patients with chronic low back pain (CLBP). METHODS: A systematic search of the Cochrane Library, Web of Science, PubMed, Embase, EBSCO, CBM, Wanfang, CNKI and VIP (until November, 2019) was used to identify studies reporting pain intensity (VAS or NRS), disability (ODI or RMDQ), JOA score, and quality of life (SF-36) in patients with CLBP. Study selection, data extraction was performed critically and independently by two reviewers. Cochrane criteria for risk of bias was used to assess the methodological q...
Source: Complementary Therapies in Clinical Practice - May 1, 2020 Category: Complementary Medicine Authors: Chen FQ, Ge JF, Leng YF, Li C, Chen B, Sun ZL Tags: Complement Ther Clin Pract Source Type: research

Teaching Chronic Pain in the Family Medicine Clerkship: Changes From 2014.
CONCLUSIONS: The majority of family medicine clerkships teach about chronic pain, and the amount of time dedicated to this topic has increased over the last 5 years. A state's opioid overdose rate correlates with the amount of time spent teaching about opioids, but does not correlate with the amount of time teaching about other chronic pain subtopics. It is possible that the opioid crisis is causing a shift in the subtopics of chronic pain teaching. PMID: 32401329 [PubMed - as supplied by publisher] (Source: Famly Medicine)
Source: Famly Medicine - May 1, 2020 Category: Primary Care Authors: Schiel KZ, Everard KM Tags: Fam Med Source Type: research

Torsion of wandering spleen nine years after gastric volvulus: Effect of multiparity?
Abstract Wandering spleen is a rare condition and has life-threatening complications, such as torsion or infarction. It may be asymptomatic or may present with chronic abdominal pain or intraabdominal mass. Since clinical diagnosis is usually difficult, radiological examinations play a very important role in diagnosis. A 37-year-old multiparous woman was admitted to the emergency room with a complaint of abdominal pain. The patient stated that she underwent an operation due to gastric volvulus nine years ago. Preoperative diagnosis was made by ultrasonography and computed tomography. Splenectomy was performed beca...
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - May 1, 2020 Category: Emergency Medicine Authors: Karaisli S, Acar T, Acar N, Kamer E, Hacıyanlı M Tags: Ulus Travma Acil Cerrahi Derg Source Type: research

Evidence Base of Clinical Studies on Qi Gong: A Bibliometric Analysis.
CONCLUSIONS: Qigong research publications have been increasing gradually. Reports on study types, participants, Qigong Intervention, and outcomes are diverse and inconsistent. There is an urgent need to develop a set of reporting standards for various interventions of Qigong. Further trials of high methodological quality with sufficient sample size and real world studies are needed to verify the effects of Qigong in health and disease management. PMID: 32444061 [PubMed - as supplied by publisher] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - May 1, 2020 Category: Complementary Medicine Authors: Zhang YP, Hu RX, Han M, Lai BY, Liang SB, Chen BJ, Robinson N, Chen K, Liu JP Tags: Complement Ther Med Source Type: research

Dose –response associations of clinical markers of obesity and duration of exposure to excess weight with chronic musculoskeletal pain: cross-sectional analysis at baseline of ELSA-Brasil Musculoskeletal cohort
The objective of this study is to investigate the association of clinical markers of obesity and weight trajectories with chronic musculoskeletal pain (CMP). This is a cross-sectional study using baseline data from ELSA-Brasil MSK cohort. CMP was evaluated at nine body sites (neck, shoulders, upper back, elbows, lower back, wrists/hands, hips/thighs, knees, ankles/feet), and defined as pain lasting  >  6 months in the past year. General and abdominal obesity levels were classified according to accepted cut-offs for body mass index (BMI), waist circumference (WC) and waist–height ratio (WHtR). Bi...
Source: Rheumatology International - April 30, 2020 Category: Rheumatology Source Type: research

Clostridioides difficile infection in a patient with immunoglobulin A vasculitis: a triggering factor or a rare complication of the disease? A case-based review
AbstractIgA vasculitis, formerly known as Henoch –Schonlein purpura (HSP), is the most common form of systemic vasculitis in children and is characterized by inflammation of the small vessels with typical deposition of IgA immune complexes. It is a leukocytoclastic type of vasculitis and is characterized by a tetrad of clinical manifestations: n on-thrombocytopenia or coagulopathy-induced palpable purpura, arthritis, or arthralgia, gastrointestinal, and renal involvement. The exact cause of IgA vasculitis is not known yet, although infections, vaccinations and insect bites have been implicated in the appearance of th...
Source: Rheumatology International - April 30, 2020 Category: Rheumatology Source Type: research