Blocking Pannexin 1 Channels Alleviates Peripheral Inflammatory Pain but not Paclitaxel-Induced Neuropathy
CONCLUSION: Our findings suggest that Panx1 is critical for developing peripheral inflammatory pain and acute nociception involving transient receptor potential vanilloid subtype 1 (TRPV1) but is not essential for neuropathic pain chronicity.PMID:38538230 | DOI:10.31083/j.jin2303064 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Julia Borges Paes Lemes Kaue Franco Malange Nathalia Santos Carvalho Amanda Ferreira Neves Marcia Urban-Maldonado Paula Regina Gelinski Kempe Catarine Massucato Nishijima Cecilia Costa Fagundes Celina Monteiro da Cruz Lotufo Sylvia Ottile Suadicani Carlos Source Type: research

Single Session Effects of Prolonged Continuous Theta Burst Stimulation Targeting Two Brain Regions on Pain Perception in Patients with Painful Diabetic Neuropathy: A Preliminary Study
CONCLUSIONS: In pDN patients with NP, our study results demonstrated significant improvement in scores on self-report measures of pain (SRMP) after a single session of pcTBS targeting the M1 and DLPFC brain regions. Future studies should consider utilizing multiple sessions of pcTBS to evaluate its long-term effects on pain perception, safety and tolerability in patients with chronic pain.CLINICAL TRIAL REGISTRATION: This study was registered on the ClinicalTrials.gov website (NCT04988321).PMID:38538225 | DOI:10.31083/j.jin2303054 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Bhushan Thakkar Carrie L Peterson Edmund O Acevedo Source Type: research

Gut Microbiota: Potential Therapeutic Target for Sickle Cell Disease Pain and Complications
CONCLUSION: Further exploration and clinical trials are needed to harness the full potential of these gut bacteria for individuals affected by this challenging condition.PMID:38533265 | PMC:PMC10965282 | DOI:10.1155/2024/5431000 (Source: Anemia)
Source: Anemia - March 27, 2024 Category: Hematology Authors: Tarimoboere Agbalalah Doofan Bur Ezinne JaneFrances Nwonu Adekunle Babajide Rowaiye Source Type: research

Heterotopic Ossification of the Abdomen: A Rare Sequela Following Trauma and Damage Control Laparotomy
We present the case of a 22-year-old man, 20 months after life-threatening motor vehicle crash with major vascular injury requiring multiple abdominal surgeries. The patient was initially treated at a community hospital and subsequently developed a chronic left lower quadrant enterocutaneous fistula, accompanied by a gradually worsening diffuse abdominal pain. He was referred to our tertiary care center with extensive skin breakdown and an inability to control the fistula despite numerous wound care consultations. He also had severe abdominal deformities due to HO in the abdominal wall, peritoneum, paraspinal muscles, and ...
Source: The American Surgeon - March 27, 2024 Category: Surgery Authors: Patrick Cherfan Michael D Cobler-Lichter Joshua P Kronenfeld Zoe Weiss Patricia M Byers Source Type: research

Relation between neutrophil-to-lymphocyte ratio with epidural analgesia timing and thoracotomy pain
CONCLUSION: It was observed that pre-emptive epidural analgesia reduced pain levels and additional analgesic consumption in the acute post-operative period in patients with pre-operative NLR ≥ 2.PMID:38537235 | DOI:10.24875/CIRU.23000161 (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - March 27, 2024 Category: Surgery Authors: Taha Semerci Ersagun Tugcugil Ahmet Besir Source Type: research

Use of compression therapy for cellulitis
CONCLUSIONS: Cellulitis frequently affects older patients, especially smokers, people with overweight and chronic lymphoedema. In all, 66% were treated with compression therapy that did not have a clear effect on their readmission rate, probably because the patients receiving compression therapy had a more severe infection complicated by severe oedema and a higher risk of reinfection. An increased focus on the use of compression therapy in conjunction with health preventive interventions may have a positive impact on the relapse rate.FUNDING: None.TRIAL REGISTRATION: Not relevant.PMID:38533881 | DOI:10.61409/A08230530 (Sou...
Source: Danish Medical Journal - March 27, 2024 Category: General Medicine Authors: Mia Nielsen Mette Midttun Source Type: research

Examining the relationship between head trauma and opioid use disorder: A systematic review
CONCLUSION: Findings indicate that therapists and clinicians must consider a risk profile for persons with TBI and follow an integrated care approach to account for mental health, prior substance misuse, presenting somatic symptoms, and current medication regimen during evaluation.PMID:38533717 | DOI:10.5055/jom.0846 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - March 27, 2024 Category: Addiction Authors: Ali Abid Maria Paracha Iva Çepele Awais Paracha Joseph Rueve Akbar Fidahussain Humza Rehman McKimmon Engelhardt Noor Alyasiry Zohair Siddiqui Satvik Vasireddy Bishal Kadariya Nikith Rao Rohan Das Wilson Rodriguez Dixie Meyer Source Type: research

Chronic opioid pain treatment converted to buprenorphine: A case series using a 3-step low-dose incremental dosing guideline
We report a 30-case series from the Pain Management Center at the Massachusetts General Hospital where we have applied a guideline to convert chronic treatment for pain from full agonist opioids (FAO) to buprenorphine (BUP). Of the patients, 24 (80 percent) elected to continue BUP over FAO. Five conversions were stopped for side effects (fatigue) and/or lack of sufficient pain reduction. One patient elected not to participate on the day that the conversion was to begin. There were no major adverse events. We conclude that conversion to BUP should be considered as an alternative to treat patients on chronic opioids for pain...
Source: Journal of Opioid Management - March 27, 2024 Category: Addiction Authors: Gregory Acampora Yi Zhang Source Type: research

Nanofiber-based wound dressing in wound healing of elderly patients
CONCLUSIONS: The use of nanofiber dressings is an effective means to promote wound healing in elderly patients, which is worthy of application in practical care.PMID:38533364 | PMC:PMC10962374 | DOI:10.5114/ada.2024.136034 (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - March 27, 2024 Category: Dermatology Authors: Anqi Li Zhenqi Jing Yunhao Liu Youxin Wang Source Type: research

Incidence and predictors of chronic pain after inguinal hernia surgery: a systematic review and meta-analysis
ConclusionsThe incidence of persistent pain following hernia repair surgery is high in current clinical practice, a concern that should not be overlooked. Stratified assessment tools need to be established for patients experiencing early chronic pain, and personalized follow-up strategies and preventive interventions should be developed for those with potentially high risks. These measures aim to enhance the quality of life for patients after hernia repair. (Source: Hernia)
Source: Hernia - March 27, 2024 Category: Sports Medicine Source Type: research

Efficacy and safety of dienogest in the treatment of deep infiltrating endometriosis: A meta-analysis
Deep infiltrating endometriosis (DIE) refers to endometriosis (EMs) with an infiltration depth greater than or equal to 5  mm. It is an invasive disease that involves the uterosacral ligament, the excavatio rectouterina, vaginal vault, vaginal-rectal septum, rectum, colon wall, bladder wall, and the ureter. DIE can cause evident chronic pelvic pain, dysmenorrhea, dyspareunia, dysuria, non-menstrual pelvic pain, local bleeding, and the obstruction of vital organs. EMs affects about 10 % of women of childbearing age. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 27, 2024 Category: OBGYN Authors: Han Wu, Jun-Jiang Liu, Sheng-Tou Ye, Jun Liu, Na Li Tags: Review article Source Type: research

Molecules, Vol. 29, Pages 1489: Development and Validation of a High-Performance Liquid Chromatography Method to Quantify Marker Compounds in Lysimachia vulgaris var. davurica and Its Effects in Diarrhea-Predominant Irritable Bowel Syndrome
In this study, using an experimental mouse model of IBS-D, we elucidated the effects of the LV extract. The methanol extract of LV decreased fecal pellet output in the restraint stress- or 5-hydroxytryptamine (5-HT)-induced IBS mouse model and inhibited 5-HT-mediated [Ca2+]i increase in a dose-dependent manner. Furthermore, we developed and validated a high-performance liquid chromatography method using two marker compounds, namely, chlorogenic acid and rutin, for quality control analysis. Our study results suggest the feasibility of the methanol extract of LV for developing therapeutic agents to treat IBS-D by acting as a...
Source: Molecules - March 27, 2024 Category: Chemistry Authors: Hye-Youn Kim Cho-Een Kim Dool-Ri Oh Yonguk Kim Chul-Yung Choi Jaeyong Kim Tags: Article Source Type: research

Rare but Still There: A Scoping Review on Endometriosis-Associated Ovarian Cancer
Discov Med. 2024 Mar;36(182):467-481. doi: 10.24976/Discov.Med.202436182.44.ABSTRACTEndometriosis is a medical condition affecting at least up to 10% of women of reproductive age. This condition occurs when ectopic endometrial glands and stroma implant outside the uterus and there are several theories regarding the underlying origins of the disease. Endometriosis is one of the major causes of severe dysmenorrhoea, chronic pelvic pain and infertility. While endometriosis is generally a non-malignant condition, it rarely may transform into an invasive cancer, and increase the risk for epithelial ovarian cancer, notably endom...
Source: Discovery Medicine - March 26, 2024 Category: Research Authors: Karl Livori Jean Calleja-Agius Source Type: research

Individual outcomes after tailored versus generic self-management strategies for persistent fatigue in youth with a fatigue syndrome or rheumatic condition: A multiple single-case study
CONCLUSION: Self-management advice has more potential when tailored to individual characteristics, including the biopsychosocial model of fatigue. PROfeel appears particularly useful as fatigue intervention for individuals with relatively less severe symptoms.PMID:38531612 | DOI:10.1111/bjhp.12722 (Source: British Journal of Health Psychology)
Source: British Journal of Health Psychology - March 26, 2024 Category: Psychiatry & Psychology Authors: Anouk Vroegindeweij Jan Houtveen Desiree A Lucassen Elise M Van De Putte Nico M Wulffraat Sanne L Nijhof Joost F Swart Source Type: research

The Silhouettes Fatigue Scale: further validation in Spanish-speaking university students and adults with chronic pain
CONCLUSIONS: The findings support the validity of the SFS scores when used to assess fatigue in undergraduates and middle-aged adults with chronic pain.PMID:38529680 | DOI:10.1080/09638288.2024.2331080 (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - March 26, 2024 Category: Rehabilitation Authors: Elisabet S ánchez-Rodríguez Josep Roman-Juan Elena Castarlenas Ester Sol é Mark P Jensen Jordi Mir ó Source Type: research