Oncology: What You May Have Missed in 2023
This article highlights important publications from 2023 on topics across a wide spectrum relating to the management of oncology patients. The literature was screened for significant new evidence that is relevant to internal medicine specialists and subspecialists whose focus is not oncology. Two articles address the importance of social interventions targeting end-of-life care for low-income and minority patients and the well-being of caregivers. Two additional articles address screening considerations in patients at risk for colorectal and lung cancer. Two more articles address safe use of hormone-related therapies to tr...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Courtney H Coschi Lorin Dodbiba DuPont Guerry Source Type: research
Primary anastomosis closure after endoscopic ultrasound-directed transgastric intervention
Conclusions Single-stage EDGI is an effective approach to managing RYGB patients with pancreaticobiliary pathology. Thus far, endoscopic TTS tack-based suturing appears to have a high success rate in anastomosis closure after LAMS removal and should be considered as a primary method for preventing chronic fistulae. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - April 15, 2024 Category: Gastroenterology Authors: Cui, YongYan Almario, Jose Antonio Bejjani, Michael Khashab, Mouen A. Irani, Shayan Tags: Original article Source Type: research
Association Between Vertebral Endplate Defects and Patient-reported Symptoms: An Immunohistochemical Study Investigating the COX-2/PGE-2/EP-4 Axis
Low back pain is characterized by discomfort, muscle tension, or stiffness located between the ribcage and the upper part of the buttocks. Low back pain persisting>3 months is termed as chronic low back pain[1], which has become a worldwide problem affecting 70% to 90% of the world's population[2]. The etiology of chronic low back pain remains a puzzle[2]. Although a variety of anatomical structures can lead to pain, components of the lumbar spine are regarded as the primary sources, with the intervertebral disc having received the most attention[3,4]. (Source: The Spine Journal)
Source: The Spine Journal - April 15, 2024 Category: Orthopaedics Authors: Haojie Chen, Qingshuang Zhou, Xiaojiang Pu, Nannan Wang, Sinian Wang, Zhenhua Feng, Bin Wang, Zezhang Zhu, Yong Qiu, Xu Sun Tags: Clinical Study Source Type: research
Cognitive horizons in chronic pain: unraveling neuroscientific insights and innovative interventions for fibromyalgia
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 15, 2024 Category: Neuroscience Source Type: research
Quercetin alleviates chronic unpredictable mild stress-induced depression-like behavior by inhibiting NMDAR1 with α2δ-1 in rats
CONCLUSIONS: Que has a good antidepressant effect and can significantly improve the depression-like behavior caused by CUMS. It exerts antidepressant effects by inhibiting the expression level of α2δ-1, interfering with the interaction between α2δ-1 and NMDAR, and then reducing the excitability of the HPA axis.PMID:38615365 | PMC:PMC11016343 | DOI:10.1111/cns.14724 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Mingyan Wang Xin Wei Yugai Jia Chaonan Wang Xinliu Wang Xin Zhang Depei Li Yuanyuan Wang Yonggang Gao Source Type: research
Decompression sickness followed by diabetic ketoacidosis and sepsis shock: an unusual case report
Undersea Hyperb Med. 2024 First Quarter;51(1):41-46.ABSTRACTDecompression sickness (DCS) is caused by abrupt changes in extracorporeal pressure with varying severity. Symptoms range from mild musculoskeletal pain to severe organ dysfunction and death, especially among patients with chronic underlying disease. Here, we report an unusual case of a 49-year-old man who experienced DCS after a dive to a depth of 38 meters. The patient's symptoms progressed, starting with mild physical discomfort that progressed to disturbance of consciousness on the second morning. During hospitalization, we identified that in addition to DCS, ...
Source: Undersea and Hyperbaric Medicine - April 14, 2024 Category: Sports Medicine Authors: Anwei Liu Xiaogan Hou Jing Nie Qiang Wen Zhiguo Pan Source Type: research
Quercetin alleviates chronic unpredictable mild stress-induced depression-like behavior by inhibiting NMDAR1 with α2δ-1 in rats
CONCLUSIONS: Que has a good antidepressant effect and can significantly improve the depression-like behavior caused by CUMS. It exerts antidepressant effects by inhibiting the expression level of α2δ-1, interfering with the interaction between α2δ-1 and NMDAR, and then reducing the excitability of the HPA axis.PMID:38615365 | PMC:PMC11016343 | DOI:10.1111/cns.14724 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Mingyan Wang Xin Wei Yugai Jia Chaonan Wang Xinliu Wang Xin Zhang Depei Li Yuanyuan Wang Yonggang Gao Source Type: research
Decompression sickness followed by diabetic ketoacidosis and sepsis shock: an unusual case report
Undersea Hyperb Med. 2024 First Quarter;51(1):41-46.ABSTRACTDecompression sickness (DCS) is caused by abrupt changes in extracorporeal pressure with varying severity. Symptoms range from mild musculoskeletal pain to severe organ dysfunction and death, especially among patients with chronic underlying disease. Here, we report an unusual case of a 49-year-old man who experienced DCS after a dive to a depth of 38 meters. The patient's symptoms progressed, starting with mild physical discomfort that progressed to disturbance of consciousness on the second morning. During hospitalization, we identified that in addition to DCS, ...
Source: Undersea and Hyperbaric Medicine - April 14, 2024 Category: Sports Medicine Authors: Anwei Liu Xiaogan Hou Jing Nie Qiang Wen Zhiguo Pan Source Type: research
The association of caffeine and nandrolone decanoate modulates aversive memory and nociception in rats
In this study, we aimed to investigate the long-term effects of ND and caffeine, either alone or in combination, on passive avoidance memory and nociception. We used the step-down and hot-plate tasks in male and female Lister Hooded rats. Our results confirmed the antinociceptive effect of caffeine and indicated that chronic administration of the ND-caffeine association promotes the evocation of aversive memory in female rats.PMID:38615923 | DOI:10.1016/j.brainres.2024.148937 (Source: Brain Research)
Source: Brain Research - April 14, 2024 Category: Neurology Authors: Daniel Bussinger de Souza Penna Samara Gumi éro Costa Alexandre Dos Santos-Rodrigues Pablo Pandolfo Source Type: research
Impact of Shared Decision-Making on Opioid Prescribing Among Patients with Chronic Pain: A Retrospective Cohort Study
This study measured whether SDM affects opioid prescribing frequency for chronic low back pain. A retrospective cohort study involving 1478 participants was conducted within a national pain research registry. The patient participation and patient orientation (PPPO) scale of the Communication Behavior Questionnaire was used to measure SDM, including classification of greater SDM (PPPO scale score≥80) or lesser SDM (PPPO scale score<80). Opioid prescribing frequency was measured at quarterly intervals from enrollment through 12 months. Baseline and longitudinal covariates were collected to adjust for potential confoundi...
Source: Pain Physician - April 14, 2024 Category: Anesthesiology Authors: John C Licciardone Braden Van Alfen Michaela N Digilio Rylan Fowers Bassam Ballout Yasser Bibi Subhash Aryal Source Type: research
Quercetin alleviates chronic unpredictable mild stress-induced depression-like behavior by inhibiting NMDAR1 with α2δ-1 in rats
CONCLUSIONS: Que has a good antidepressant effect and can significantly improve the depression-like behavior caused by CUMS. It exerts antidepressant effects by inhibiting the expression level of α2δ-1, interfering with the interaction between α2δ-1 and NMDAR, and then reducing the excitability of the HPA axis.PMID:38615365 | PMC:PMC11016343 | DOI:10.1111/cns.14724 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Mingyan Wang Xin Wei Yugai Jia Chaonan Wang Xinliu Wang Xin Zhang Depei Li Yuanyuan Wang Yonggang Gao Source Type: research
The association of caffeine and nandrolone decanoate modulates aversive memory and nociception in rats
In this study, we aimed to investigate the long-term effects of ND and caffeine, either alone or in combination, on passive avoidance memory and nociception. We used the step-down and hot-plate tasks in male and female Lister Hooded rats. Our results confirmed the antinociceptive effect of caffeine and indicated that chronic administration of the ND-caffeine association promotes the evocation of aversive memory in female rats.PMID:38615923 | DOI:10.1016/j.brainres.2024.148937 (Source: Brain Research)
Source: Brain Research - April 14, 2024 Category: Neurology Authors: Daniel Bussinger de Souza Penna Samara Gumi éro Costa Alexandre Dos Santos-Rodrigues Pablo Pandolfo Source Type: research
Impact of Shared Decision-Making on Opioid Prescribing Among Patients with Chronic Pain: A Retrospective Cohort Study
This study measured whether SDM affects opioid prescribing frequency for chronic low back pain. A retrospective cohort study involving 1478 participants was conducted within a national pain research registry. The patient participation and patient orientation (PPPO) scale of the Communication Behavior Questionnaire was used to measure SDM, including classification of greater SDM (PPPO scale score≥80) or lesser SDM (PPPO scale score<80). Opioid prescribing frequency was measured at quarterly intervals from enrollment through 12 months. Baseline and longitudinal covariates were collected to adjust for potential confoundi...
Source: Pain Physician - April 14, 2024 Category: Anesthesiology Authors: John C Licciardone Braden Van Alfen Michaela N Digilio Rylan Fowers Bassam Ballout Yasser Bibi Subhash Aryal Source Type: research
Evaluation of the thickness of the transverse muscles of the abdomen and the internal oblique muscles using ultrasound imaging in women with back pain
It has been estimated that chronic low back pain (LBP) affects 18% of young people, and 28-42% of people in middle age, with women being more affected than men. Chronic LBP can arise from a variety of factors, among which are biomechanical changes in core muscles, such as in their thickness, which can impair spinal stability. (Source: Journal of Bodywork and Movement Therapies)
Source: Journal of Bodywork and Movement Therapies - April 14, 2024 Category: Physiotherapy Authors: Priscila Kalil Morelh ão, Viviane Akemi Kakazu, Ygor Matos Luciano, Crystian Bitencourt Soares Oliveira, Rafael Zambelli Pinto, Cynthia Gobbi, Paulo Fernandes Pires, Fabrício José Jassi Source Type: research
Quantitative measurement of dural ectasia: associations with clinical and genetic characteristics in Marfan syndrome
ConclusionOur study shed further light on the relationship between genotype, dural pathology, and the overall clinical spectrum of MFS. The identification of protein-truncating variants and those impacting cysteine content may therefore suggest closer patient monitoring, in order to address potential complications associated with DE. (Source: European Spine Journal)
Source: European Spine Journal - April 14, 2024 Category: Orthopaedics Source Type: research
