Interactive Association Between Mechanical and Sensorimotor Aspects of Cervical Extensor Muscles: Implications for Chronic Neck Pain.
Authors: Ghamkhar L, Amiri Arimi S, Kahlaee AH Abstract While proprioceptive functioning of the cervical extensor muscles has been proposed to be associated with chronic neck pain (NP), the mechanism by which such impairment might contribute to NP is not clear. The aim of this cross-sectional study was to investigate the relevance of proprioception, extensor muscles size, and endurance to chronic NP. A total of 60 participants with (n = 30) or without (n = 30) chronic NP participated in this cross-sectional study. Joint repositioning error (JRE), ultrasonographic parameters of the cervical extensors, and clinical e...
Source: Journal of Applied Biomechanics - May 2, 2020 Category: Sports Medicine Tags: J Appl Biomech Source Type: research

Prevalence of Burnout Syndrome Among Students of Health Care Colleges and its Correlation to Musculoskeletal Disorders in Saudi Arabia
Conclusions:Burnout, as well as MSDs, are prevalent among students of health care colleges. Burnout seems to be a risk factor for MSDs. Social media campaigns andawareness campaigns about burnout should be promoted.Keywords:Burnout, musculoskeletal pain, prevalence, psychological, students (Source: International Journal of Preventive Medicine)
Source: International Journal of Preventive Medicine - May 2, 2020 Category: International Medicine & Public Health Source Type: research

Infected Schmorl ’s node: a case report
Schmorls node (SN) are mostly asymptomatic and incidental findings on MRI. However, sometimes they present like acute onset low back pain or acute exacerbation of chronic back pain after minor trauma. (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - May 2, 2020 Category: Orthopaedics Authors: Hyeun Sung Kim, Harshavardhan Dilip Raorane, Sagar Bhupendra Sharma, Pang Hung Wu and Il-Tae Jang Tags: Case report Source Type: research

Molecular Aspects of Regional Pain Syndrome.
Abstract The purpose of this review is to summarize the pathophysiology of complex regional pain syndrome (CRPS), the underlying molecular mechanisms, and potential treatment options for its management. CRPS is a multifactorial pain condition. CRPS is characterized by prolonged or excessive pain and changes in skin color and temperature, and/or swelling in the affected area, and is generally caused by stimuli that lead to tissue damage. An inflammatory response involving various cytokines and autoantibodies is generated in response to acute trauma/stress. Chronic phase pathophysiology is more complex, involving th...
Source: Pain Research and Management - May 1, 2020 Category: Anesthesiology Authors: Baronio M, Sadia H, Paolacci S, Prestamburgo D, Miotti D, Guardamagna VA, Natalini G, Sullivan SGB, Bertelli M Tags: Pain Res Manag Source Type: research

Tapentadol Prolonged Release for Severe Chronic Osteoarthritis Pain in the Elderly-A Subgroup Analysis of Routine Clinical Practice Data.
Conclusion: Tapentadol PR provided effective and well-tolerated treatment of severe chronic OA pain for elderly patients in routine clinical practice. The favorable tolerability profile in particular suggests tapentadol PR as a treatment option before classical strong opioids are considered. PMID: 32351639 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - May 1, 2020 Category: Anesthesiology Authors: Schwittay A, Sohns M, Heckes B, Elling C Tags: Pain Res Manag Source Type: research

Standard Correction of Vision Worsens EMG Activity of Pericranial Muscles in Chronic TMD Subjects.
The objective of this work was to evaluate the effects of standard vision correction on EMG in subjects suffering from TMD compared with application of the same vision treatments to non-TMD subjects. 40 subjects were enrolled in this study. The test group included 20 myopic subjects and also included patients with TMD. The control group included 20 healthy myopic subjects. All of the participants underwent a complete ocular examination and a sEMG analysis. The results showed that TMD subjects with vision disorders that are corrected with standard glasses present EMG values that are significantly higher than those presented...
Source: Pain Research and Management - May 1, 2020 Category: Anesthesiology Authors: Monaco A, Ortu E, Giannoni M, D'Andrea P, Cattaneo R, Mummolo A, Pietropaoli D Tags: Pain Res Manag Source Type: research

The Relationship of Sleep Duration with Ethnicity and Chronic Disease in a Canadian General Population Cohort.
Abstract Study Objectives: Sleep duration is an important marker of sleep quality and overall sleep health. Both too little and too much sleep are associated with poorer health outcomes. We hypothesized that ethnicity-specific differences in sleep duration exist. Methods: This cross-sectional study utilized questionnaire data from the Ontario Health Study (OHS), a multi-ethnic population-based cohort of Canadian adult residents aged 18 to 99 years, who provided medical, socio-demographic, and sleep information. Generalised linear models were used to investigate the association of sleep duration with ethnicity...
Source: Pain Physician - May 1, 2020 Category: Anesthesiology Authors: Singh M, Hall KA, Reynolds A, Palmer LJ, Mukherjee S Tags: Nat Sci Sleep Source Type: research

Bilateral stellate ganglion block for migraine: A case report
Rationale: Migraine is a recurrent, disabling neurovascular headache disorder. The patient's quality of life can be severely impaired by migraine attacks. Stellate ganglion block (SGB) can be used to relieve pain in the head, neck, and upper extremities. In the present cases, we performed SGB in 2 patients with migraine that responds poorly to drugs. Patient concerns: Patients 1 and 2 suffered from chronic, bilateral pulsating headache, accompanied by nausea and vomiting. Patient 1 presented with headache of 8 on the visual analog scale (VAS), and 37 on the migraine disability assessment (MIDAS). Patient 2 reported he...
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Traumatic Brain Injury and Opioid Overdose Among Post-9/11 Veterans With Long-Term Opioid Treatment of Chronic Pain
Conclusion: TBI status, especially in the context of comorbid conditions, should be considered in clinical decisions regarding long-term use of opioids in patients with chronic pain. (Source: The Journal of Head Trauma Rehabilitation)
Source: The Journal of Head Trauma Rehabilitation - May 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Occurrence of lymphoplasmacytic lymphoma in a chronic myeloid leukemia patient following long-term treatment with tyrosine kinase inhibitors: A case report
Conclusion: Herein, for the first time, we describe a patient who developed LPL as a secondary malignancy after administration of TKIs for the treatment of CML. Our observations indicate the importance of awareness of this secondary malignancy that can develop in CML patients treated with TKIs. (Source: Medicine)
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Bilateral radial collateral ligament rupture in a shoemaker: A case report and brief literature review
Conclusion: Compared to acute RCL rupture of the index MCP joint, occupation may play an important role in the diagnosis of chronic RCL rupture of the index MCP joint. Our report will provide more diagnostic and treatment experience to deal with this type of injury. (Source: Medicine)
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Prevalence of postmastectomy pain syndrome and associated risk factors: A large single-institution cohort study
Postmastectomy pain syndrome (PMPS) is a frequent complication of breast surgery, and is considered a chronic neuropathic pain in the side of surgery which persists more than 3 months. We conducted a retrospective analysis of the largest reported cohort to investigate the prevalence of PMPS and to analyze its associated risk factors as well as the influence on quality of life (QoL). Two thousand thirty-three surgically-treated female patients diagnosed between 2012 and 2017 with early-stage breast cancer were asked to complete a questionnaire survey about their current chronic neuropathic pain problems and quality of life....
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

A clinical study on safety and efficacy of Naesohwajung-tang on functional dyspepsia
Discussion: This trial will evaluate the safety and efficacy of NHT as a treatment of FD. The results of this trial will not only verify whether NHT improves FD symptoms and gastric myoelectrical activity, but also clarify those correlations. Trial registration number: CRIS KCT0003405. (Source: Medicine)
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Personalized electro-acupuncture versus auricular-acupuncture comparative effectiveness (PEACE): A protocol of a randomized controlled trial for chronic musculoskeletal pain in cancer survivors
We describe the design of a 3-arm, parallel, single-center, multisite randomized controlled trial that investigates EA and BFA versus usual-care wait-list control (WLC) for chronic musculoskeletal pain among 360 patients with diverse cancer types across various stages. The primary aim is to compare effects of EA and BFA versus WLC on pain, physical function, and co-morbid symptoms. The secondary aim is to examine the interaction between patient outcome expectancy and acupuncture modality (EA vs BFA) on pain reduction. The tertiary aim is to evaluate the association between genetic polymorphisms and responses to acupuncture...
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Vocal cord involvement and hoarseness in a patient with Behcets disease: A rare case report
Rationale: Behcets disease (BD) is a type of chronic systemic vasculitis that typically manifests as a mucocutaneous disease with orogenital ulcers, skin damage, and uveitis. The clinical diagnosis is often difficult because of the diversity of organs that may be involved and lack of specific pathological diagnosis. Patient concerns: A 26-year-old woman presented as a nearly 2-week history of hoarseness with throat pain. Diagnoses: In the present case, Fiber laryngoscopy showed multiple ulcers involving the epiglottic tubercle, bilateral false vocal cord, middle area of the left vocal cord, and full length of the r...
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Impact of herbs and dietary supplements in patients with fibromyalgia: A protocol for a systematic review and meta-analysis of randomized controlled trials
Conclusion: The findings may provide a framework for future research and clinic practice in FM management. PROSPERO registration number: CRD42020149941 (Source: Medicine)
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Isokinetic back training is more effective than core stabilization training on pain intensity and sports performances in football players with chronic low back pain: A randomized controlled trial
Conclusion: This study suggests that training through IKT improves pain intensity and sports performances than CST in university football players with chronic LBP. (Source: Medicine)
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Lipid rafts in glial cells: role in neuroinflammation and pain processing [Thematic Reviews]
Activation of microglia and astrocytes secondary to inflammatory processes contributes to the development and perpetuation of pain with a neuropathic phenotype. This pain state presents as a chronic debilitating condition and affects a large population of patients with conditions like rheumatoid arthritis and diabetes, or after surgery, trauma, or chemotherapy. Here, we review the regulation of lipid rafts in glial cells and the role they play as a key component of neuroinflammatory sensitization of central pain signaling pathways. In this context, we introduce the concept of an inflammaraft (i-raft), enlarged lipid rafts ...
Source: The Journal of Lipid Research - May 1, 2020 Category: Lipidology Authors: Miller, Y. I., Navia-Pelaez, J. M., Corr, M., Yaksh, T. L. Tags: Thematic Reviews Source Type: research

MKP1 in the medial prefrontal cortex modulates chronic neuropathic pain via regulation of p38 and JNK1/2
. (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - May 1, 2020 Category: Neuroscience Authors: Yiling Qian Zhiyong Wang Siqi Zhou Weinan Zhao Cui Yin Junli Cao Zhiping Wang Yanqiang Li Source Type: research

Blunted Pain Modulation Response to Induced Stress in Women with Fibromyalgia with and without Posttraumatic Stress Disorder Comorbidity: New Evidence of Hypo-Reactivity to Stress in Fibromyalgia?
o Pérez JL, González Gutierrez JL Abstract There is evidence regarding the presence of alterations in both the stress response and the endogenous pain modulation systems of people with fibromyalgia (FM). However, research on pain modulation under induced stress on FM patients is scarce and contradictory. The present study analyzes stress-induced changes in pain and intolerance thresholds among FM patients, examining the possible existence of differences linked to PTSD comorbidity and gaining insights into the role of cardiovascular reactivity. Eighteen women diagnosed with FM and comorbid PTSD (FM&th...
Source: Behavioral Medicine - May 1, 2020 Category: Psychiatry Authors: López-López A, Matías-Pompa B, Fernández-Carnero J, Gil-Martínez A, Alonso-Fernández M, Alonso Pérez JL, González Gutierrez JL Tags: Behav Med Source Type: research

Symptom Management Among Cancer Survivors: Randomized Pilot Intervention Trial of Heart Rate Variability Biofeedback.
ke MA Abstract Chronic cancer-related symptoms (stress, fatigue, pain, depression, insomnia) may be linked with sympathetic nervous system over-activation and autonomic imbalance. Decreased heart rate variability (HRV) is an indicator of autonomic dysregulation that is commonly observed among cancer survivors. HRV biofeedback (HRVB) training induces HRV coherence, which maximizes HRV and facilitates autonomic and cardiorespiratory homeostasis. This randomized, wait-list-controlled, pilot intervention trial tested the hypothesis that HRVB can improve HRV coherence and alleviate cancer-related symptoms. The interven...
Source: Applied Psychophysiology and Biofeedback - May 1, 2020 Category: Psychiatry & Psychology Authors: Burch JB, Ginsberg JP, McLain AC, Franco R, Stokes S, Susko K, Hendry W, Crowley E, Christ A, Hanna J, Anderson A, Hébert JR, O'Rourke MA Tags: Appl Psychophysiol Biofeedback Source Type: research

Efficacy of acupressure for chronic low back pain: A systematic review.
CONCLUSION: Acupressure is a feasible, effective, safe, low cost nonpharmacologic method to treat CLBP. PMID: 32379678 [PubMed - as supplied by publisher] (Source: Complementary Therapies in Clinical Practice)
Source: Complementary Therapies in Clinical Practice - May 1, 2020 Category: Complementary Medicine Authors: Godley E, Smith MA Tags: Complement Ther Clin Pract Source Type: research

Efficacy and safety of moxibustion for chronic low back pain: A systematic review and meta-analysis of randomized controlled trials.
Abstract INTRODUCTION: To systematically review and meta-analyze the efficacy of moxibustion in treating patients with chronic low back pain (CLBP). METHODS: A systematic search of the Cochrane Library, Web of Science, PubMed, Embase, EBSCO, CBM, Wanfang, CNKI and VIP (until November, 2019) was used to identify studies reporting pain intensity (VAS or NRS), disability (ODI or RMDQ), JOA score, and quality of life (SF-36) in patients with CLBP. Study selection, data extraction was performed critically and independently by two reviewers. Cochrane criteria for risk of bias was used to assess the methodological q...
Source: Complementary Therapies in Clinical Practice - May 1, 2020 Category: Complementary Medicine Authors: Chen FQ, Ge JF, Leng YF, Li C, Chen B, Sun ZL Tags: Complement Ther Clin Pract Source Type: research

Teaching Chronic Pain in the Family Medicine Clerkship: Changes From 2014.
CONCLUSIONS: The majority of family medicine clerkships teach about chronic pain, and the amount of time dedicated to this topic has increased over the last 5 years. A state's opioid overdose rate correlates with the amount of time spent teaching about opioids, but does not correlate with the amount of time teaching about other chronic pain subtopics. It is possible that the opioid crisis is causing a shift in the subtopics of chronic pain teaching. PMID: 32401329 [PubMed - as supplied by publisher] (Source: Famly Medicine)
Source: Famly Medicine - May 1, 2020 Category: Primary Care Authors: Schiel KZ, Everard KM Tags: Fam Med Source Type: research

Torsion of wandering spleen nine years after gastric volvulus: Effect of multiparity?
Abstract Wandering spleen is a rare condition and has life-threatening complications, such as torsion or infarction. It may be asymptomatic or may present with chronic abdominal pain or intraabdominal mass. Since clinical diagnosis is usually difficult, radiological examinations play a very important role in diagnosis. A 37-year-old multiparous woman was admitted to the emergency room with a complaint of abdominal pain. The patient stated that she underwent an operation due to gastric volvulus nine years ago. Preoperative diagnosis was made by ultrasonography and computed tomography. Splenectomy was performed beca...
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - May 1, 2020 Category: Emergency Medicine Authors: Karaisli S, Acar T, Acar N, Kamer E, Hacıyanlı M Tags: Ulus Travma Acil Cerrahi Derg Source Type: research

Evidence Base of Clinical Studies on Qi Gong: A Bibliometric Analysis.
CONCLUSIONS: Qigong research publications have been increasing gradually. Reports on study types, participants, Qigong Intervention, and outcomes are diverse and inconsistent. There is an urgent need to develop a set of reporting standards for various interventions of Qigong. Further trials of high methodological quality with sufficient sample size and real world studies are needed to verify the effects of Qigong in health and disease management. PMID: 32444061 [PubMed - as supplied by publisher] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - May 1, 2020 Category: Complementary Medicine Authors: Zhang YP, Hu RX, Han M, Lai BY, Liang SB, Chen BJ, Robinson N, Chen K, Liu JP Tags: Complement Ther Med Source Type: research

Dose –response associations of clinical markers of obesity and duration of exposure to excess weight with chronic musculoskeletal pain: cross-sectional analysis at baseline of ELSA-Brasil Musculoskeletal cohort
The objective of this study is to investigate the association of clinical markers of obesity and weight trajectories with chronic musculoskeletal pain (CMP). This is a cross-sectional study using baseline data from ELSA-Brasil MSK cohort. CMP was evaluated at nine body sites (neck, shoulders, upper back, elbows, lower back, wrists/hands, hips/thighs, knees, ankles/feet), and defined as pain lasting  >  6 months in the past year. General and abdominal obesity levels were classified according to accepted cut-offs for body mass index (BMI), waist circumference (WC) and waist–height ratio (WHtR). Bi...
Source: Rheumatology International - April 30, 2020 Category: Rheumatology Source Type: research

Clostridioides difficile infection in a patient with immunoglobulin A vasculitis: a triggering factor or a rare complication of the disease? A case-based review
AbstractIgA vasculitis, formerly known as Henoch –Schonlein purpura (HSP), is the most common form of systemic vasculitis in children and is characterized by inflammation of the small vessels with typical deposition of IgA immune complexes. It is a leukocytoclastic type of vasculitis and is characterized by a tetrad of clinical manifestations: n on-thrombocytopenia or coagulopathy-induced palpable purpura, arthritis, or arthralgia, gastrointestinal, and renal involvement. The exact cause of IgA vasculitis is not known yet, although infections, vaccinations and insect bites have been implicated in the appearance of th...
Source: Rheumatology International - April 30, 2020 Category: Rheumatology Source Type: research

Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury.
Abstract The neurochemical mechanisms underlying neuropathic pain (NP) are related to peripheral and central sensitization caused by the release of inflammatory mediators in the peripheral damaged tissue and ectopic discharges from the injured nerve, leading to a hyperexcitable state of spinal dorsal horn neurons. The aim of this work was to clarify the role played by cyclooxygenase (COX) in the lesioned peripheral nerve in the development and maintenance of NP by evaluating at which moment the non-steroidal anti-inflammatory drug indomethacin, a non-selective COX inhibitor, attenuated mechanical allodynia after p...
Source: Braz J Med Biol Res - April 30, 2020 Category: Research Authors: Medeiros P, Dos Santos IR, Medeiros AC, da Silva JA, Ferreira SH, de Freitas RL, Coimbra NC Tags: Braz J Med Biol Res Source Type: research

[ASAP] P2Y < sub > 14 < /sub > Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00115 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - April 30, 2020 Category: Chemistry Authors: Fatma Mufti †, Young-Hwan Jung‡, Luigino Antonio Giancotti†, Jinha Yu‡, Zhoumou Chen†, Ngan B. Phung‡, Kenneth A. Jacobson*‡, and Daniela Salvemini*† Source Type: research

Chronic Pain Syndromes and Their Laryngeal Manifestations
This case series analyzes the differences in presentation of voice and laryngeal disorders in patients with fibromyalgia, irritable bowel syndrome, and/or chronic fatigue syndrome. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 30, 2020 Category: ENT & OMF Source Type: research

Polytetrafluoroethylene versus polypropylene mesh during laparoscopic totally extraperitoneal (TEP) repair of inguinal hernia: short- and long-term results of a double-blind clinical randomized controlled trial
AbstractPurposeAim of the study is to compare macroporous (>  1 mm2) polytetrafluoroethylene mesh (LP-PTFE) versus microporous (
Source: Hernia - April 30, 2020 Category: Sports Medicine Source Type: research

Local Anesthetic Injection Resolves Movement Pain, Motor Dysfunction, and Pain Catastrophizing in Individuals With Chronic Achilles Tendinopathy, a Non-Randomized Clinical Trial
Journal of Orthopaedic&Sports Physical Therapy, Ahead of Print. (Source: The Journal of Orthopaedic and Sports Physical Therapy)
Source: The Journal of Orthopaedic and Sports Physical Therapy - April 30, 2020 Category: Physiotherapy Authors: Ruth L. Chimenti Mederic M. Hall Connor P. Dilger Ericka N. Merriwether Jason M. Wilken Kathleen A. Sluka Source Type: research

Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation
In this study, we hypothesized that endothelial cells (EC) carry thePIK3CA mutations and play a major role in the cellular origin of CLVM. We isolated EC from the lesions of seven patients with CLVM and identifiedPIK3CA hotspot mutations. The CLVM EC exhibited constitutive phosphorylation of the PI3K effector AKT as well as hyperproliferation and increased resistance to cell death compared to normal EC. Inhibitors of PIK3CA (BYL719) and AKT (ARQ092) attenuated the proliferation of CLVM EC in a dose-dependent manner. A xenograft model of CLVM was developed by injecting patient-derived EC into the flanks of immunocompromised...
Source: Angiogenesis - April 30, 2020 Category: Molecular Biology Source Type: research

“Triaging” Chronic Migraine Patients in Need of CGRP(r) Monoclonal Antibodies
(Source: Pain and Therapy)
Source: Pain and Therapy - April 30, 2020 Category: Anesthesiology Source Type: research

A Balanced Approach for Cannabidiol Use in Chronic Pain
Cannabidiol (CBD), the major non-psychoactive constituent of Cannabis sativa L., has gained traction as a potential treatment for intractable chronic pain in many conditions. Clinical evidence suggests that CBD provides therapeutic benefit in certain forms of epilepsy and imparts analgesia in certain conditions, and improves quality of life. CBD continues to be Schedule I or V on the list of controlled substances of the Drug Enforcement Agency of the United States. However, preparations labeled CBD are available publicly in stores and on the streets. However, use of CBD does not always resolve pain. CBD purchased freely en...
Source: Frontiers in Pharmacology - April 30, 2020 Category: Drugs & Pharmacology Source Type: research

Criterion validity of two mobile applications to count the number of steps in older adults with chronic pain
. (Source: European Journal of Physiotherapy)
Source: European Journal of Physiotherapy - April 30, 2020 Category: Rehabilitation Authors: Jos é Ferreira Alexandra Queir ós Anabela G. Silva Source Type: research

Motivational Interviewing and Return to Work for People with Musculoskeletal Disorders: A Systematic Mapping Review
Conclusions This mapping review identified a huge gap in research on MI to increase return to work for individuals with musculoskeletal disorders.Registration Current Research Information System in Norway, project id: 635823 ( (Source: Journal of Occupational Rehabilitation)
Source: Journal of Occupational Rehabilitation - April 30, 2020 Category: Rehabilitation Source Type: research

Ultrasound Parasternal Block as a Novel Approach for Cardiac Sternal Surgery: Could it Be the Safest Strategy?
Respiratory complications  are a major factor contributing to postoperative morbidity and mortality, especially in patients with chronic obstructive pulmonary disease (COPD). To minimize respiratory complications, minimally invasive approaches to cardiac surgery in addition to regional anesthesia are being used.1 Cardiac surgery most commonly is performed via median sternotomy, which results in significant intraoperative and postoperative pain and a high incidence of chronic pain. When sternal dehiscence occurs, sternal resynthesis most commonly is performed with general anesthesia and intravenous opioid adm...
Source: Journal of Cardiothoracic and Vascular Anesthesia - April 30, 2020 Category: Anesthesiology Authors: Giuseppe Sepolvere, Mario Tedesco, Loredana Cristiano Tags: Letter to the Editor Source Type: research

Fear in the context of pain: Lessons learned from 100 years of fear conditioning research.
We describe the different pain-related fear conditioning paradigms using proprioceptive and interoceptive CSs and painful stimuli as USs that have been developed to study specific forms of pain-related fear (i.e. fear of movement, fear of touch, fear of visceral sensations, and fear of penetration) that are relevant for different chronic pain conditions (i.e. musculoskeletal pain, neuropathic pain, visceral pain, and genital pain). We present evidence that patients with chronic pain demonstrate impaired safety learning and excessive fear generalization; learning anomalies that have also been observed in anxiety disorders. ...
Source: Behaviour Research and Therapy - April 30, 2020 Category: Psychiatry & Psychology Authors: Meulders A Tags: Behav Res Ther Source Type: research

10 & nbsp;kHz Spinal Cord Stimulation for Combined Alleviation of Post-Laminectomy Syndrome and Chronic Abdominal Pain: A Case Report
(Source: Journal of Pain Research)
Source: Journal of Pain Research - April 29, 2020 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Exercise and Chronic Pain.
Authors: Borisovskaya A, Chmelik E, Karnik A Abstract In this chapter, we describe the impact and etiology of chronic pain, the associated changes in the nervous system, and the mechanisms by which exercise may be able to affect and reverse these changes. Evidence for efficacy of exercise in different conditions associated with chronic pain is presented, with focus on chronic low back pain, fibromyalgia, osteoarthritis, rheumatoid arthritis, and migraines. While the efficacy of exercise and level of evidence supporting it vary in different diseases, exercise has direct and indirect benefits for most patients suffer...
Source: Advances in Experimental Medicine and Biology - April 29, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Comparative Effectiveness of Treatments for Chronic Low Back Pain
No abstract available (Source: Journal of Spinal Disorders and Techniques)
Source: Journal of Spinal Disorders and Techniques - April 29, 2020 Category: Surgery Tags: Letter to the Editor Source Type: research

Platelet-Rich Plasma Versus Corticosteroids in the Treatment of Chronic Plantar Fasciitis: A Systematic Review and Meta-analysis of Prospective Comparative Studies
The objective of this review was to compare platelet-rich plasma injection (PRP) and corticosteroids injection in the treatment of chronic plantar fasciitis. MEDLINE, PubMed, Web of Science, EMBASE, and the Cochrane library of clinical trials were searched in March 2019. Inclusion criteria were prospective comparative studies reporting functional scores or pain score with a minimum follow-up of 1 month. (Source: Journal of Foot and Ankle Surgery)
Source: Journal of Foot and Ankle Surgery - April 29, 2020 Category: Orthopaedics Authors: Nedal Alkhatib, Motasem Salameh, Abdulaziz F. Ahmed, Eslam Alkaramany, Ghalib Ahmed, Mohamed M. Mekhaimar, Jasim Alsaei Source Type: research

Agomelatine potentiates anti-nociceptive effects of morphine in a mice model for diabetic neuropathy: involvement of NMDA receptor subtype NR1 within the raphe nucleus and periaqueductal grey.
Discussion: The combination of agomelatine with morphine alone causes outlasting analgesic effects of repeated treatment, which can be interpreted as attenuated tolerance. Moreover, we also pointed out for the first time the modulatory effects of agomelatine on GluN1 expression in raphe nucleus and PAG after chronic morphine treatment.Abbreviations: Ca2+: Calcium; D2DR: Dopamine D2 receptor; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; GluN1: Glutamate ionotropic receptor N-methyl-D-aspartate type subunit-1; 5-HT: 5-hydroxytryptamine; i.p.: intraperitoneal injection; MPE: Maximal possible effect; MT: Melatonin; NMDA: N...
Source: Neurological Research - April 29, 2020 Category: Neurology Tags: Neurol Res Source Type: research

An uncommon cause of chronic abdominal pain and diarrhea.
We present the case of a 57-years-old male, with a history of 4-5 months of diffuse abdominal pain, watery diarrhoea due to this infection. The colonoscopy revealed a serpiginous ulcer in the cecum. The biopsy was positive for intestinal spirochaetosis. It is rare infection, more common among immunocompromised patients and HIV, with a faecal-oral transmission. Most cases are incidental findings in the endoscopic screening. In symptomatic patients the watery diarrhoea and non-specific abdominal pain are the most common symptoms. The macroscopic appearance on the colonoscopy is often normal or non-specific lesions can be ide...
Source: Revista Espanola de Enfermedades Digestivas - April 29, 2020 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

Laparoscopic Beger procedure for the treatment of chronic pancreatitis: a single-centre first experience
The Beger procedure is a common surgical option in the management of the unremitting abdominal pain of chronic pancreatitis (CP). As an organ-sparing surgery, it might be a better choice than pancreatoduodenec... (Source: BMC Surgery)
Source: BMC Surgery - April 29, 2020 Category: Surgery Authors: He Cai, Yunqiang Cai, Xin Wang and Bing Peng Tags: Case report Source Type: research

Pediatric chronic myeloid leukemia: A single-center experience
Conclusion: Pediatric CML in India is comparable with Western countries regarding epidemiological characteristic, clinical presentations, and tolerance of imatinib. As there is a paucity of universal literature regarding pediatric CML (especially data from Southeast Asian region), this article may fill up that space. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - April 29, 2020 Category: Cancer & Oncology Authors: Irappa Madabhavi Apurva Patel Gaurang Modi Asha Anand Harsha Panchal Sonia Parikh Source Type: research

From transformation to chronification of migraine: pathophysiological and clinical aspects
AbstractChronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8  days show typical migraine features. The process that describes the development from episodic migraine into chronic migraine is commonly referred to as migraine transformation or chronification. Ample studies have attempted to identify factors associated with migraine transformation from differen t perspectives. Understanding CM as a pathological brain state with trigeminovascular participation where biological changes occur, we have completed a comprehensive review on the clinical, epidemiolo...
Source: The Journal of Headache and Pain - April 29, 2020 Category: Neurology Source Type: research

A global real-world assessment of the impact on health-related quality of life and work productivity of migraine in patients with insufficient versus good response to triptan medication
AbstractBackgroundMigraine is a chronic, disabling neurological disease characterized by moderate-to-severe headache pain with other symptoms, including nausea, vomiting, and photophobia. Triptans, while generally effective, are insufficiently efficacious in 30 –40% of patients and poorly tolerated by or contraindicated in others. We assessed the impact of insufficient response to triptans on health-related quality of life (HRQoL) and work productivity in patients currently receiving any prescribed triptan formulation as their only acute migraine medicat ion.MethodsData were from the 2017 Adelphi Migraine Disease Spe...
Source: The Journal of Headache and Pain - April 29, 2020 Category: Neurology Source Type: research