Orofacial Antinociceptive Effect of Nifedipine in Rodents Is Mediated by TRPM3, TRPA1, and NMDA Processes.
Authors: de Oliveira BA, Alves Rodrigues Santos SA, Menezes Pereira EW, Nogueira AB, Vieira Neto AE, de Melo Júnior JMA, Damasceno MBMV, Quintans-Júnior LJ, Sessle BJ, Magalhães FEA, Campos AR Abstract AIMS: To test for the possible antinociceptive effect of nifedipine in rodent models of acute and chronic neuropathic orofacial pain and the possible involvement of TRP- and NMDA-related processes in this effect. METHODS: Acute nociceptive behavior was induced by administering formalin, cinnamaldehyde, glutamate, capsaicin, or acidified saline to the upper lip or hypertonic saline to the corn...
Source: Journal of Orofacial Pain - April 8, 2020 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Bridging the Gap Among Clinical Practice Guidelines for Pain Management in Cancer and Sickle Cell Disease.
Authors: Schatz AA, Oliver TK, Swarm RA, Paice JA, Darbari DS, Dowell D, Meghani SH, Winckworth-Prejsnar K, Bruera E, Plovnick RM, Richardson L, Vapiwala N, Wollins D, Hudis CA, Carlson RW Abstract Opioids are a critical component of pain relief strategies for the management of patients with cancer and sickle cell disease. The escalation of opioid addiction and overdose in the United States has led to increased scrutiny of opioid prescribing practices. Multiple reports have revealed that regulatory and coverage policies, intended to curb inappropriate opioid use, have created significant barriers for many patients....
Source: Journal of the National Comprehensive Cancer Network : JNCCN - April 8, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Chronic Pain in Hidradenitis Suppurativa Explained Through the Process of Central Sensitization
This Viewpoint discusses the current understanding about the mechanisms by which inflammation may modify pain perception via central sensitization in hidradenitis suppurativa and stresses the importance of future research into pain perception and management in these patients. (Source: JAMA Dermatology)
Source: JAMA Dermatology - April 8, 2020 Category: Dermatology Source Type: research

Botulinum toxin type A ameliorates adjuvant-arthritis pain by inhibiting microglial activation-mediated neuroinflammation and intracellular molecular signaling.
Abstract Chronic inflammatory pain is a serious clinical problem caused by inflammation of the joints and degenerative diseases and greatly affects patients' quality of life. Persistent pain states are thought to result from the central sensitization of nociceptive pathways in the spinal dorsal horn. Spinal microglia-mediated neuroinflammation plays a pivotal role in the development and maintenance of the central sensitization of chronic inflammatory pain. Botulinum toxin type A (BoNT/A) was recently reported to have analgesic and anti-inflammatory effects. However, the precise mechanism underlying its analgesic e...
Source: Toxicon - April 8, 2020 Category: Toxicology Authors: Shi X, Gao C, Wang L, Chu X, Shi Q, Yang H, Li T Tags: Toxicon Source Type: research

Neuropathic pain after thoracotomy: tracking signs and symptoms before and at monthly intervals following surgery
ConclusionsClinical routine should focus on the individual ’s physiological state, including pre‐existing neuropathic pain and sleep quality to identify patients early who might be at risk to develop chronic post‐surgical neuropathic pain. (Source: European Journal of Pain)
Source: European Journal of Pain - April 8, 2020 Category: Anesthesiology Authors: W. Gandhi, F.B. Pomares, L. Naso, J.F. Asenjo, P. Schweinhardt Tags: ORIGINAL ARTICLE Source Type: research

Effect of dynamic stabilisation exercise therapy enhanced with muscles energy technique on some selected patients outcomes and trunk muscles function in patients with chronic non-specific low back pain: a study protocol
. (Source: European Journal of Physiotherapy)
Source: European Journal of Physiotherapy - April 8, 2020 Category: Rehabilitation Authors: Usman Abba Ahmed Thaya Nadasan Jessica Van Oosterwijck Sonill Sooknunan Maharaj Source Type: research

Diagnosing Peripheral Neuropathy in South East Asia: A Focus on Diabetic Neuropathy
AbstractBurning and stabbing pain in the feet and lower limbs can have a significant impact on the activities of daily living including walking, climbing stairs and sleeping. Peripheral neuropathy (PN) in particular is often misdiagnosed or underdiagnosed due to a lack of awareness amongst both patients and physicians. Furthermore, crude screening tools such as the 10g monofilament only detect advanced neuropathy and a normal test will lead to false reassurance of those with small fiber mediated painful neuropathy. The underestimation of PN is highly prevalent in the South East Asia (SEA) region due to a lack of consensus ...
Source: Journal of Diabetes Investigation - April 8, 2020 Category: Endocrinology Authors: RA. Malik, A. Andag ‐Silva, C. Dejthevaporn, M. Hakim, JS. Koh, R. Pinzon, N. Sukor, KS. Wong Tags: REVIEW Source Type: research

Anxiolytic-like effects of mirogabalin, a novel ligand for α2δ ligand of voltage-gated calcium channels, in rats repeatedly injected with acidic saline intramuscularly, as an experimental model of fibromyalgia.
CONCLUSIONS: Sluka model rats exhibited anxiety-like behaviours in the open field test and the elevated plus maze test, but mirogabalin alleviated these behaviours. Mirogabalin might thus have the potential to relieve anxiety in fibromyalgia patients. PMID: 32270470 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2020 Category: Drugs & Pharmacology Authors: Murasawa H, Kobayashi H, Yasuda SI, Saeki K, Domon Y, Arakawa N, Kubota K, Kitano Y Tags: Pharmacol Rep Source Type: research

Yoga improves balance, mobility, and perceived occupational performance in adults with chronic brain injury: A preliminary investigation.
CONCLUSION: We observed significant improvements in balance, mobility, and self-reported occupational performance in adults with chronic brain injury. PMID: 32347208 [PubMed - as supplied by publisher] (Source: Complementary Therapies in Clinical Practice)
Source: Complementary Therapies in Clinical Practice - April 8, 2020 Category: Complementary Medicine Authors: Stephens JA, Van Puymbroeck M, Sample PL, Schmid AA Tags: Complement Ther Clin Pract Source Type: research

Single Cupping Thearpy Session Improves Pain, Sleep, and Disability in Patients with Nonspecific Chronic Low Back Pain
Publication date: Available online 21 November 2019Source: Journal of Acupuncture and Meridian StudiesAuthor(s): Maria P. Volpato, Izabela C.A. Breda, Ravena C. de Carvalho, Caroline de Castro Moura, Laís L. Ferreira, Marcelo L. Silva, Josie R.T. Silva (Source: Journal of Acupuncture and Meridian Studies)
Source: Journal of Acupuncture and Meridian Studies - April 7, 2020 Category: Complementary Medicine Source Type: research

Investigating the Effect of Perioperative Chlorzoxazone on Acute Postoperative Pain After Total Hip and Knee Replacement Surgery
Conclusion: The current study demonstrated no analgesic effects of postoperative chlorzoxazone administration compared with placebo on acute or chronic postoperative pain 12 months following TKR and THR. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 7, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Attitudes Towards and Management of Opioid-induced Hyperalgesia: A Survey of Chronic Pain Practitioners
Discussion: Most clinicians agreed that OIH is a complication of opioid therapy, but were divided regarding the prevalence of OIH, etiological factors, and optimal management. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 7, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Social Factors, Disability, and Depressive Symptoms in Adults With Chronic Pain
Discussion: The study provides important new findings regarding the associations between social factors and physical and psychological functioning of individuals with chronic pain, supporting biopsychosocial models. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 7, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Association Between Inflammatory Biomarkers and Nonspecific Low Back Pain: A Systematic Review
Discussion: Our findings support the notion of a positive association between inflammatory biomarkers and nonspecific LBP, specifically for CRP, TNFs, and IL-6. Although further high quality longitudinal studies are needed to confirm these findings and evaluate the magnitude of these associations, our findings suggest a role of inflammation in the pathogenesis of nonspecific LBP. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 7, 2020 Category: Anesthesiology Tags: Review Articles Source Type: research

Validating Invalidation: Examining the Construct Validity of the Illness Invalidation Inventory Among Individuals With Chronic Low Back Pain
Discussion: The 2-factor model of the 3*I “family members” subscale identified in the current study reflects previous findings and extends the psychometric validity of the 3*I to a US multiethnic sample of individuals with CLBP. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 7, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Post-Traumatic Stress Disorder Symptoms Contribute to Worse Pain and Health Outcomes in Veterans With PTSD Compared to Those Without: A Systematic Review With Meta-Analysis.
CONCLUSION: In veterans with chronic pain, PTSD symptomology has a large effect for many negative health-related outcomes. This review supports the need for clinicians to screen and understand the effects of PTSD symptoms on patients with pain. Clinicians should recognize that veterans with PTSD and pain likely have elevated pain catastrophizing beliefs and decreased self-efficacy that should be targeted for intervention. PMID: 32248229 [PubMed - as supplied by publisher] (Source: Military Medicine)
Source: Military Medicine - April 7, 2020 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Neuroimmune modulation of pain and regenerative pain medicine
Regenerative pain medicine, which seeks to harness the body’s own reparative capacity, is rapidly emerging as a field within pain medicine and orthopedics. It is increasingly appreciated that common analgesic mechanisms for these treatments depend on neuroimmune modulation. In this Review, we discuss recent progress in mechanistic understanding of nociceptive sensitization in chronic pain with a focus on neuroimmune modulation. We also examine the spectrum of regenerative outcomes, including preclinical and clinical outcomes. We further distinguish the analgesic mechanisms of regenerative therapies from those of cell...
Source: Journal of Clinical Investigation - April 7, 2020 Category: Biomedical Science Authors: Thomas Buchheit, Yul Huh, William Maixner, Jianguo Cheng, Ru-Rong Ji Source Type: research

Sahaj Samadhi Meditation versus a Health Enhancement Program for depression in chronic pain: protocol for a randomized controlled trial and implementation evaluation
Despite the high prevalence of comorbid chronic pain and depression, this comorbidity remains understudied. Meditation has demonstrated efficacy for both chronic pain and depression independently, yet there ha... (Source: Trials)
Source: Trials - April 7, 2020 Category: General Medicine Authors: Abhimanyu Sud, Michelle L. A. Nelson, Darren K. Cheng, Alana Armas, Kirk Foat, Michelle Greiver, Fardous Hosseiny, Joel Katz, Rahim Moineddin, Benoit H. Mulsant, Ronnie I. Newman, Leon Rivlin, Akshya Vasudev and Ross Upshur Tags: Study protocol Source Type: research

Efficacy of the World Health Organization analgesic ladder in the paclitaxel-induced pain syndrome in rats
AbstractPaclitaxel use in cancer treatment is limited by a painful syndrome that has no effective treatment. Despite new therapies, drugs of the World Health Organization (WHO) analgesic ladder remain a useful therapeutic tool for cancer pain relief. Since cancer pain is caused by both tumor and chemotherapy, we assessed the efficacy of drugs from the WHO analgesic ladder for cancer pain relief in a paclitaxel-induced pain syndrome (P-IPS) model. P-IPS was induced in rats by one or four injections of paclitaxel on alternate days. The acute and chronic phases were assessed 24  h and 15 days after the first paclita...
Source: Inflammopharmacology - April 7, 2020 Category: Drugs & Pharmacology Source Type: research

A prospective longitudinal study of clinical outcome and quality of life assessment in patients with chronic rhinosinusitis after functional endoscopic sinus surgery using sino nasal outcome test-22
AbstractChronic rhinosinusitis (CRS) significantly affect the quality of life (QoL) of patients. The study was conducted in CRS patients who were treated with functional endoscopic sinus surgery (FESS) after failure of medical treatment to analyze clinical outcome using prospectively collected data through a symptom-based rhinosinusitis outcome measure, the Sino-nasal Outcome Test-22 (SNOT-22). The aim of the study was to evaluate and compare the QoL in patients of chronic rhinosinusitis pre-operative and after FESS by SNOT-22. The prospective study was conducted on 40 patients of chronic rhinosinusitis with or without nas...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 7, 2020 Category: ENT & OMF Source Type: research

Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy
AbstractBackgroundWe aimed to assess the efficacy and safety of erenumab, a fully human monoclonal antibody inhibiting the calcitonin gene-related peptide receptor (CGRPr), for the prevention of migraine in a real-life setting.Main bodyWe included in our observational study all patients with episodic or chronic migraine treated with erenumab during the year 2019 in the Abruzzo region, central Italy, and with a 6-month follow-up. We included 89 patients; 76 (85.4%) received 6 doses of erenumab, 11 (12.4%) autonomously withdrew the drug due to perceived inefficacy, and 2 (2.2%) due to adverse events. Seventy-eight patients (...
Source: The Journal of Headache and Pain - April 7, 2020 Category: Neurology Source Type: research

Prospective pilot study to identify psychological factors influencing peri-operative pain in total knee arthroplasty (TKA)
ConclusionsParallel (or anti-parallel) and partially correlated developments of pain improvement and parameters of psychological impairment or coping strategies after TKA suggest a pre-operative screening with tools like the FESV BE and BW or TAS and SOMS questionnaires in order to classify individuals for peri-operative mental training. (Source: International Orthopaedics)
Source: International Orthopaedics - April 7, 2020 Category: Orthopaedics Source Type: research

Identification of symptom clusters and their influencing factors in subgroups of patients with acute exacerbation of chronic obstructive pulmonary disease in a Chinese population
Limited studies have identified symptom clusters (SCs) and their risk factors and the relationships with inflammatory biomarkers in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 7, 2020 Category: Palliative Care Authors: Zhenjiao Yang, Miaoling Cui, Xiaofang Zhang, Jing Bai, Lian Tang, Guirong Tan, Yun Jiang Source Type: research

[Acupuncture for pain and allergic rhinitis-from clinical experience to evidence].
DISCUSSION: As a nonpharmacological procedure, acupuncture is becoming increasingly important in pain and allergy therapy and is therefore increasingly included in current guidelines. In further studies, the efficacy of acupuncture should be determined in other indications and the mechanisms of action of this therapy method should be investigated. PMID: 32266488 [PubMed - as supplied by publisher] (Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz)
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - April 7, 2020 Category: International Medicine & Public Health Authors: Brinkhaus B, Ortiz M, Dietzel J, Willich S Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research

Identification of Symptom Clusters and Their Influencing Factors in Subgroups of Chinese Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Limited studies have identified symptom clusters (SCs) and their risk factors and the relationships with inflammatory biomarkers in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 7, 2020 Category: Palliative Care Authors: Zhenjiao Yang, Miaoling Cui, Xiaofang Zhang, Jing Bai, Lian Tang, Guirong Tan, Yun Jiang Tags: Original Article Source Type: research

Chronic Spinal Pain and Financial Worries in the US Adult Population
Conclusion. This study shows that financial worries were significantly associated with chronic spinal pain. Financial worries may be important to be taken into consideration by clinicians managing patients with spinal pain. More future research is needed to explore the association between financial worries and spinal pain. Level of Evidence: 3 (Source: Spine)
Source: Spine - April 6, 2020 Category: Orthopaedics Tags: EPIDEMIOLOGY Source Type: research

Translation, Cross-cultural Adaptation, and Psychometric Properties of the Hausa Versions of the Numerical Pain Rating Scale and Global Rating of Change Scale in a Low-literate Population With Chronic Low Back Pain
Conclusions. The NPRS and GRCS were successfully adapted into Hausa language with acceptable reliability, validity, and responsiveness. These measures are appropriate for clinical and research use among Hausa-speaking patients. Level of Evidence: 2 (Source: Spine)
Source: Spine - April 6, 2020 Category: Orthopaedics Tags: HEALTH SERVICES RESEARCH Source Type: research

Mechanical Aspects of Intervertebral Disc Injury and Implications on Biomechanics
Conclusion. The mode of loading has an important impact on the severity and nature of failures seen in IVDs and the resulting consequences to biomechanics. However, further research is necessary to better understand to the mechanisms that link injury to degeneration and regeneration of IVD tissues. Level of Evidence: 3 (Source: Spine)
Source: Spine - April 6, 2020 Category: Orthopaedics Tags: LITERATURE REVIEW Source Type: research

The inhibiting role of periaqueductal gray metabotropic glutamate receptor subtype 8 in a rat model of central neuropathic pain.
In this study, we tried to assess the modulatory effect of (S)-3,4-Dicarboxyphenylglycine (DCPG), a metabotropic glutamate receptor subtype 8 (mGluR8) agonist, in a model of chronic central neuropathic pain in male rats. We used a spinal cord contusion method (T6-T8) for the induction of chronic central neuropathic pain.Male Wistar rats were randomly assigned to 5 equal groups (n = 10 per group). Clips compression injury model was used to induce chronic central neuropathic pain. Three weeks after spinal cord injury DCPG, siRNA and normal saline were administered intra-ventrolaterally to the periaqueductal gray (P...
Source: Neurological Research - April 6, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Primary hyperparathyroidism and pancreatitis
ConclusionsWe conclude that pancreatitis can be the only presenting complaint of PHPT. Our study highlights the importance of fully investigating for PHPT in any pancreatitis patient with high normal or raised serum calcium level, especially in the absence of other common causes of pancreatitis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 6, 2020 Category: Endocrinology Source Type: research

A new ultrasound score for the assessment and follow-up of chronic pancreatitis: The ‘Gemelli USCP score’
: Ultrasound (US) is frequently the first line imaging technique used in patients with abdominal pain and clinical suspicion of chronic pancreatitis (CP), but its role in the diagnosis and follow-up of CP is still controversial. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 6, 2020 Category: Gastroenterology Authors: Danilo Pagliari, Maria Elena Ainora, Maria Gabriella Brizi, Marco Cintoni, Emanuele Rinninella, Fabia Attili, Francesco A. Mancarella, Matteo Garcovich, Laura Riccardi, Maurizio Pompili, Antonio Gasbarrini, Riccardo Manfredi, Maria Assunta Zocco Tags: Liver, Pancreas and Biliary Tract Source Type: research

Factors Secreted from Dental Pulp Stem Cells Show Multifaceted Benefits for Treating Experimental Temporomandibular Joint Osteoarthritis
In this study, we aimed to investigate effective therapies to reverse or suppress TMJOA progression. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 6, 2020 Category: Rheumatology Authors: Naoko Ogasawara, Fumiya Kano, Noboru Hashimoto, Hiroki Mori, Liu Yao, Xia Linze, Takuma Sakamaki, Hideharu Hibi, Tsutomu Iwamoto, Eiji Tanaka, Akihito Yamamoto Source Type: research

Do somatic symptoms relate to PTSD and gender after earthquake exposure? A cross-sectional study on young adult survivors in Italy.
CONCLUSION.: This study corroborates a relevant impact of symptomatological PTSD, across both the genders, on somatic symptoms occurring in young adults after months from exposure to a massive earthquake. PMID: 32248878 [PubMed - as supplied by publisher] (Source: CNS Spectrums)
Source: CNS Spectrums - April 6, 2020 Category: Neurology Authors: Carmassi C, Dell'Oste V, Barberi FM, Pedrinelli V, Cordone A, Cappelli A, Cremone IM, Rossi R, Bertelloni CA, Dell'Osso L Tags: CNS Spectr Source Type: research

Treatments for priapism in boys and men with sickle cell disease.
CONCLUSIONS: There is a lack of evidence for the benefits or risks of the different treatments for both stuttering and fulminant priapism in sickle cell disease. This systematic review has clearly identified the need for well-designed, adequately-powered, multicentre randomised controlled trials assessing the effectiveness of specific interventions for priapism in sickle cell disease. PMID: 32251534 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 6, 2020 Category: General Medicine Authors: Chinegwundoh FI, Smith S, Anie KA Tags: Cochrane Database Syst Rev Source Type: research

Early clinical outcomes for treatment of post-thrombotic syndrome and common iliac vein compression with a hybrid Oblique self-expanding nitinol stent - the TOPOS study.
Abstract Background: Physical attributes of conventional stents used in the ilio-caval territory are often unfavorable in the presence of external compression close to the bifurcation. A hybrid oblique stent was developed for the treatment of common iliac vein compression without compromising the contralateral iliac vein inflow. Patients and methods: The ongoing international monitored TOPOS study enrolled 60 patients with post-thrombotic syndrome (PTS) treated with the sinus-Obliquus stent (optimed) and provisional distal stent extension. At 3-month follow-up, patency rates were obtained from duplex ultrasound, ...
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - April 6, 2020 Category: Surgery Authors: Sebastian T, Lichtenberg M, Schlager O, Jalaie H, de Graaf R, Erbel C, Massmann A, Schindewolf M, Grigorean A, Kucher N Tags: Vasa Source Type: research

[Autoinflammatory syndromes and AA amyloidosis].
SO Abstract Autoinflammatory syndromes (AIS) are characterized by uniform attacks often with febrile episodes, exanthema, abdominal pain, muscle and joint pain. Patients show markedly elevated levels of the inflammatory serum parameters C‑reactive protein (CRP) and systemic amyloid A (SAA) during an attack. The origin of the family of the patient and the duration of the attacks are helpful to find the appropriate diagnosis. Molecular genetic tests are used to confirm the clinical diagnosis of an AIS. Colchicine can prevent attacks of familial Mediterranean fever but not the other forms of AIS. In refractory cas...
Source: Zeitschrift fur Rheumatologie - April 6, 2020 Category: Rheumatology Authors: Blank N, Schönland SO Tags: Z Rheumatol Source Type: research

In vivo intrathecal IL-1 β quantification in rats: monitoring the molecular signals of neuropathic pain.
In vivo intrathecal IL-1β quantification in rats: monitoring the molecular signals of neuropathic pain. Brain Behav Immun. 2020 Apr 06;: Authors: Arman A, Deng F, Goldys EM, Liu G, Hutchinson MR Abstract BACKGROUND: Neuropathic pain, or pain after nerve injury, is a disorder with a significant reliance on the signalling of cytokines such as IL-1β. However, quantifying the cytokine release repeatedly over time in vivo is technically challenging. AIM: To evaluate if changes in IL-1β are correlated with the presentation of mechanical allodynia over time, by repeatedly quantifying intr...
Source: Brain, Behavior, and Immunity - April 6, 2020 Category: Neurology Authors: Arman A, Deng F, Goldys EM, Liu G, Hutchinson MR Tags: Brain Behav Immun Source Type: research

Medical Reasons for Marijuana Use, Forms of Use, and Patient Perception of Physician Attitudes Among the US Population
ConclusionAmericans are using marijuana to treat medical conditions despite lack of evidence of efficacy. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - April 6, 2020 Category: Internal Medicine Source Type: research

Coronary Artery Disease: From Mechanism to Clinical Practice.
Authors: Shao C, Wang J, Tian J, Tang YD Abstract In most developed countries, coronary artery disease (CAD), mostly caused by atherosclerosis of coronary arteries, is one of the primary causes of death. From 1990s to 2000s, mortality caused by acute MI declined up to 50%. The incidence of CAD is related with age, gender, economic, etc. Atherosclerosis contains some highly correlative processes such as lipid disturbances, thrombosis, inflammation, vascular smooth cell activation, remodeling, platelet activation, endothelial dysfunction, oxidative stress, altered matrix metabolism, and genetic factors. Risk factors ...
Source: Advances in Experimental Medicine and Biology - April 5, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Safety of calcipotriene and betamethasone dipropionate foam for the treatment of psoriasis.
Authors: Amat-Samaranch V, Puig L Abstract Introduction: Psoriasis vulgaris is a chronic inflammatory skin disease characterized by well-demarcated red and scaly plaques. Most patients have mild disease that is usually controlled with topical treatment. Calcipotriene 0.05% and betamethasone dipropionate 0.064% (Cal/BD) in aerosol foam (Enstilar®) is a novel formulation, which has shown promising results in terms of efficacy and safety.Areas covered: This review evaluates the safety profile of Cal/BD aerosol foam and also the key points regarding to its efficacy. A literature search was performed in PubMed on No...
Source: Expert Opinion on Drug Safety - April 5, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Facial pain – an interdisciplinary challenge
Facial pain – an interdisciplinary challenge Swiss Dent J. 2020 Apr 06;(4):321-327 Authors: Gierthmuehlen M, Gierthmuehlen P, Hugger A, Gierthmuehlen J, Tuerp JC Abstract Acute pain has a warning function and is necessary to survive. Conversely, chronic or recurrent pain is a pathological entity itself and has tremendous impact on the quality of life of the patients . Facial pain is very common and can have various causes. The trigeminal nerve innervates the face, and tumours along its intracranial way as well as peripheral injury can lead to facial pain. Also, infections and systemic diseases, l...
Source: Schweizer Monatsschrift fur Zahnmedizin - April 5, 2020 Category: Dentistry Tags: Swiss Dent J Source Type: research

The mysterious "mental illness" of a philosopher: the case of Blaise Pascal.
Conclusions: Pascal's philosophy reflects his own inner life, which was deeply influenced by the organic affections he suffered. PMID: 32239123 [PubMed - in process] (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Translation, Cultural Adaptation and Validation of the Current Opioid Misuse Measure for European Portuguese.
CONCLUSION: The implementation of this questionnaire may reduce the incidence and morbimortality of opioid misuse among chronic pain patients and should improve chronic pain treatment in Portugal. PMID: 32238240 [PubMed - in process] (Source: Acta Medica Portuguesa)
Source: Acta Medica Portuguesa - April 4, 2020 Category: General Medicine Tags: Acta Med Port Source Type: research

[Pain catastrophizing and medication overuse in patients with chronic migraine].
Abstract INTRODUCTION: Migraine is a frequent and debilitating primary headache. Pain catastrophizing is a negative set activated in response to anticipated or actual pain. The anticipatory fear of pain, one of its characteristics, has been associated with a greater prescription and use of analgesics. AIM: To explore the pain catastrophizing in relation to analgesic overuse and the headache impact on quality of life in patients with chronic migraine. PATIENTS AND METHODS: An observational cross-sectional analytical study was performed. Patients older than 18 years with chronic migraine were included, who...
Source: Revista de Neurologia - April 4, 2020 Category: Neurology Authors: Barral E, Buonanotte F Tags: Rev Neurol Source Type: research

Long-term consequences in survivors of critical illness. Analysis of incidence and risk factors.
This study investigates the incidence of long-term consequences in survivors of critical illness 6 months after ICU care. A retrospective analysis of the risk factors was also completed. METHODS: A mixed-method design was used. A qualitative design was used in the questionnaire study (phase 1), and a quantitative design was used for the retrospective study (phase 2). RESULTS: 116 patients were interviewed. Forty-eight patients (41.4%) reported at least one long-term consequence 6 months after ICU discharge. The most frequent consequences were anxiety (n = 33, 28.4%), depression (n = 32, 27.6%) and chronic pain (n =...
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Veterans Team Recovery Integrative Immersion Process (Vet TRIIP): A Qualitative Evaluation of Participation and Impact.
CONCLUSIONS: Evaluative studies on organizations that support Veterans are useful to gauge the effectiveness and impact. Through this study, Veterans expressed perceived strengths and weaknesses of the program so further development and appropriate services will be provided. Similar studies on the impact of non-profit organizations are encouraged. Vet TRIIP significantly impacts the lives of many through stress and pain reduction, potentially preventing suicide. PMID: 32236440 [PubMed - as supplied by publisher] (Source: Military Medicine)
Source: Military Medicine - April 4, 2020 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Reduction of opioid intake after cooled radiofrequency denervation for sacroiliac joint pain: a retrospective evaluation up to 1 year.
Conclusions: CRF denervation of the SIJ can safely elicit pain and disability relief, and reduce opioid use, regardless of intervention success. Future studies may support CRF denervation as a dependable therapy to alleviate opioid use in patients with SIJ-derived LBP and show that opioid use measurements can be a surrogate indicator of pain. PMID: 32235019 [PubMed] (Source: Korean Journal of Pain)
Source: Korean Journal of Pain - April 4, 2020 Category: Anesthesiology Tags: Korean J Pain Source Type: research

Increased calcium-mediated cerebral processes after peripheral injury: possible role of the brain in complex regional pain syndrome.
Conclusions: The calcium-mediated cerebral process occurs after peripheral injury in CRPS, and there can be a relationship between the cerebrum and the pathogenesis of CRPS. PMID: 32235013 [PubMed] (Source: Korean Journal of Pain)
Source: Korean Journal of Pain - April 4, 2020 Category: Anesthesiology Tags: Korean J Pain Source Type: research

Transcutaneous electrical nerve stimulation, acupuncture, and spinal cord stimulation on neuropathic, inflammatory and, non-inflammatory pain in rat models.
Authors: Sato KL, Sanada LS, Silva MDD, Okubo R, Sluka KA Abstract Background: Transcutaneous electrical nerve stimulation (TENS), manual acupuncture (MA), and spinal cord stimulation (SCS) are used to treat a variety of pain conditions. These non-pharmacological treatments are often thought to work through similar mechanisms, and thus should have similar effects for different types of pain. However, it is unclear if each of these treatments work equally well on each type of pain condition. The purpose of this study was to compared the effects of TENS, MA, and SCS on neuropathic, inflammatory, and non-inflammatory ...
Source: Korean Journal of Pain - April 4, 2020 Category: Anesthesiology Tags: Korean J Pain Source Type: research

Spinal cord stimulation in chronic pain: technical advances.
Authors: Isagulyan E, Slavin K, Konovalov N, Dorochov E, Tomsky A, Dekopov A, Makashova E, Isagulyan D, Genov P Abstract Chronic severe pain results in a detrimental effect on the patient's quality of life. Such patients have to take a large number of medications, including opioids, often without satisfactory effect, sometimes leading to medication abuse and the pain worsening. Spinal cord stimulation (SCS) is one of the most effective technologies that, unlike other interventional pain treatment methods, achieves long-term results in patients suffering from chronic neuropathic pain. The first described mode of SCS...
Source: Korean Journal of Pain - April 4, 2020 Category: Anesthesiology Tags: Korean J Pain Source Type: research