Treatment of Pain and Opioid Use Disorder
In 2016, more than 400,000 Americans were prescribed methadone or buprenorphine for opioid use disorder treatment. The number of people on medications for opioid use disorder treatment is expected to increase now that nurse practitioners and physician assistants can prescribe buprenorphine for this treatment. Pain management nurses are faced with the challenges of managing both acute and chronic pain in individuals taking medications for opioid use disorder treatment across the continuum of care. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Kathleen Broglio, Barbara St. Marie Source Type: research

R8Preventing Post-operative Chronic/Persistent Pain Using Gabapentinoids
Postoperative pain is cited by twenty percent of patients attending pain clinics as the cause of their chronic pain, it is reveled in other articles this number may be as high as forty percent. (Reddi, D. and Curran, N.2013). Chronic/Persistent pain is defined as persistent pain lasting at least six months. Chronic pain postoperatively is associated with increased morbidity, delayed recovery time, and decrease in quality of life. Post-operative pain control is inadequate in eighty percent of the population and remains a health care challenge (Gan, T.J., 2017). (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Ben Keck Source Type: research

R6Student Nurse Attitudes and Knowledge Regarding Chronic Pain in the Older Adult
This study utilized a pre-test, post-test repeated measures design to answer three research questions that were derived from the work of Krathwohl and the Theory on the Taxonomy for Affective Domain of Learning. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Catherine Sargent Source Type: research

R3Is TENS a Feasible Non-Pharmacologic Adjunctive Treatment for Post-operative Orthopedic Pain?
This study was reviewed and approved by the hospital ’s IRB prior to implementation. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Kaylyn M. Williams Source Type: research

R2Improving the Safety of Opioid Therapy (ISOT): Exploring Components of a Nurse-led Multi-Component Intervention
Prescription opioid use remains a common treatment for chronic pain despite its uncertain efficacy and significant risks. There is an urgent need for programs designed to reduce harms and increase safety related to prescription opioids, especially in the primary care setting. There are currently few multicomponent education and support programs for both patients and clinicians regarding long-term opioid use, and there remains a need for pragmatic interventions delivered in the primary care setting. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Patricia Maloy Source Type: research

C16Brainstorming a Way Out of Pain and into Health: Developing a Self-Management Plan
The aim of this investigation was to evaluate modalities that can be used in a self-management plan for chronic pain. With the focus shifting off opioid management and onto safer alternatives, nurses and patients need to be aware of these modalities. In addition, the culture of health care is shifting from the patient as a passive participant to the patient as an active participant both in goal setting and intervention for their improved health. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Megan A. Filoramo Source Type: research

C15Pain Management: A Process Not a Pill
The aim of this investigation was to identify the non-opioid options that can be utilized to care for the chronic pain patient. In the face of the opioid epidemic, it is imperative that pain management utilizes every available option to maximize patient benefit and safety while minimizing patient risk. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Megan A. Filoramo Source Type: research

C14Compounded Oral Ketamine: A Potential Addition to Your Toolbox for the Treatment of Chronic Pain
Ketamine is a non-opioid, NMDA receptor antagonist that can be used to safely treat pain int he ambulatory setting. Since 1994, our practice has treated>200 patients with this medication and concluded 25-35% experienced persistent pain reduction without AEs. We have made use of ketamine as a nasal spray, compounded oral ketamine (COK) and IV ketamine infusions. We found oral ketamine resulted in fewer adverse side effects while providing superior analgesic efficacy. Possibly, it is because it takes advantage of the first-pass metabolite, norketamine, which is felt to have greater analgesic effect than the parent agent. ...
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Lynn Tancrati, Claire Simpson, Alfred L. McKee Source Type: research

C12Treatment with Methylnaltrexone in Patients with Opioid-Induced Constipation with or without Active Cancer
Subcutaneous (SC) methylnaltrexone (MNTX, Relistor ®) is approved for opioid-induced constipation (OIC) in adults with chronic noncancer pain and OIC in adults with advanced illness or with active cancer who require opioid dosage escalation for palliative care. This post hoc analysis evaluated data pooled from 3 randomized studies of patients with advanced illness and OIC. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Michelle Rhiner Source Type: research

C9Validation, Hope, and Empowerment through a Nurse-led Interactive Session on Fibromyalgia and Chronic Fatigue
This presentation will highlight the goals of nurses while co-facilitating a psycho-educational class for patients who have just received a diagnosis (or confirmation of a previous diagnosis) of fibromyalgia. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Lynn M. Rose, Connie A. Luedtke, Mary M. Volcheck, Bree E. Clark, Shirley M. Johnson, Abigail J. Ledvina Source Type: research

6AEvaluating and Treating Opioid Withdrawal Symptoms in Patients on Chronic Opioid Therapy
The aim of this investigation/presentation is to provide clinical perspectives on accurately identifying and treating opioid withdrawal symptoms. As providers continue to be encouraged to taper patients off of chronic opioid therapy and the incidence of opioid withdrawal symptoms rises, this clinical knowledge is becoming increasingly necessary. Effectively managing opioid withdrawal symptoms will decrease barriers to tapering and provide more successful outcomes and an improved experience for this patient population. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Molly McNaughton, Leslie Maynard Source Type: research

5D2Do All Patients Need Opioids after Cardiac Surgery? Nope!
Cardiac surgery is well known for producing intense acute and chronic post-surgical pain. Traditionally opioids are the primary analgesic during length of stay. The recent culture shift to reduce patient exposure to the short and long-term harms related to opioid use creates opportunities to think and practice differently. The question "Are there patients that use opioids, not because they need them but because we encourage their use, make them too accessible, and don't provide alternatives?" drove this work. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Jason Sawyer Source Type: research

5D1Behavioral Symptom Clusters, Inflammation, and Quailty of Life in Chronic Low Back Pain
Chronic low back pain (CLBP) is a prevalent condition, often involving an inflammatory process. Those with CLBP frequently experience behavioral symptoms, including depressed mood, fatigue, and sleep disturbance, which may exacerbate pain and reduce quality of life (QOL). The purpose of this study was to identify behavioral symptom clusters (depressive mood, fatigue, poor sleep) in individuals with CLBP, and to determine whether there are differences in pain, QOL and inflammation (plasma IL-6) based on cluster membership. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 12, 2020 Category: Nursing Authors: Anitha Saravanan Source Type: research

The Interplay of Parent and Child Coping Responses in Understanding Child Functioning in the Context of Living With a Parent With or Without Chronic Pain
Discussion: The current findings demonstrated that child functioning was associated with maternal and child pain catastrophizing, but only in children of mothers without CP. No evidence was found in support of maternal pain coping responses as vulnerability or protective factors in the context of parental CP. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - March 12, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

The Complex Interplay of Pain, Depression, and Anxiety Symptoms in Patients With Chronic Pain: A Network Approach
This study aimed to analyze the associations among depressive and anxiety and pain symptoms in patients diagnosed with chronic pain. Materials and Methods: Four hundred fifty-four inpatients who were consecutively admitted in a multimodal 3-week treatment in a tertiary, psychosomatic university clinic completed 25 items from the Brief Pain Inventory and the Hospital Anxiety and Depression Scale at baseline and after treatment termination. Associations among symptoms were explored by network analyses using the graphical least absolute shrinkage and selection operator to estimate their partial correlations, whereas Extend...
Source: The Clinical Journal of Pain - March 12, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Clinical Scenarios for Which Cervical Mobilization and Manipulation Are Considered by an Expert Panel to Be Appropriate (and Inappropriate) for Patients With Chronic Neck Pain
Conclusions: Clinical guidelines for CNP should include information on the clinical scenarios for which cervical mobilization and manipulation were found inappropriate, including those with red flags, and others involving major neurological findings if previous manual therapy was unfavorable. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - March 12, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Targeting Occipital Headache Pain: Preliminary Data Supporting an Alternative Approach to Occipital Nerve Block
This study evaluated the efficacy and validity of an alternative, single skin insertion, paresthesia-based approach to block both the greater and lesser occipital nerve. Materials and Methods: Patients with a clinical diagnosis of occipital headache were included in this study. External landmarks of the cervical spinous process and ipsilateral tragus were used to predict the location of the OA pulse at the superior nuchal line. Alternative ONB technique was used to block both the greater and lesser occipital nerves using single skin insertion and paresthesia confirmation. Demographic data, preprocedure, and postprocedur...
Source: The Clinical Journal of Pain - March 12, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Adherence to Consolidated Standards of Reporting Trials (CONSORT) Guidelines for Reporting Safety Outcomes in Trials of Medical Cannabis and Cannabis-based Medicines for Chronic Noncancer Pain: A Systematic Review
Discussion: Better harms assessment and reporting are needed in chronic pain cannabinoid trials. Improvements may be achieved through: expanded education/knowledge translation increased research regulation by ethics boards, funding agencies and journals, and greater emphasis on safety assessment and reporting throughout research training. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - March 12, 2020 Category: Anesthesiology Tags: Review Article Source Type: research

Unsuspected Accessory Ossicle in Possible Sinus Tarsi Syndrome: The Value of Bone SPECT/CT
Three-phase bone scan was performed for evaluation of possible sinus tarsi syndrome in a 52-year-old man with chronic left ankle pain. MRI was initially read as unremarkable, and there was little symptomatic improvement after intra-articular anesthetic injection. The primary finding that appreciated only delayed bone SPECT/CT images was focal increased uptake associated with a well-corticated 8-mm bony fragment adjacent to the left calcaneus, thought to represent an accessory ossicle within the left sinus tarsi. The increased uptake suggested fracture or severe degenerative change of the ossicle, likely contributing to the...
Source: Clinical Nuclear Medicine - March 12, 2020 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Dientamoeba fragilis in children: A systematic review on diagnostic considerations and efficacy of treatment.
Authors: van Kalleveen MW, van Gool T, Klarenbeek N, Benninga MA, Savelkoul PHM, de Meij T, Plötz FB Abstract Introduction: The presence of D. fragilis in feces is characterized by asymptomatic carrier ship to a spectrum of gastrointestinal symptoms. However, a causal relationship remains to be elucidated. In this systematic review we aimed to evaluate the relationship between eradication of D. fragilis and symptoms to establish the strength of evidence that D. fragilis in symptomatic children warrants antibiotic treatment.Areas covered: This systematic review covers a challenge in daily clinical practice. Is ...
Source: Expert Review of Gastroenterology and Hepatology - March 12, 2020 Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research

Kinesiophobia is not required to predict chronic low back pain in workers: a decision curve analysis
Currently used performance measures for discrimination were not informative to determine the clinical benefit of predictor variables. The purpose was to evaluate if a former relevant predictor, kinesiophobia, ... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - March 12, 2020 Category: Orthopaedics Authors: A. M. Panken, J. B. Staal and M. W. Heymans Tags: Research article Source Type: research

Magnetic resonance visualization of iron-loaded meshes in patients with pain after inguinal hernia repair
ConclusionMesh position and deformation as shrinkage can be the mesh-related cause of pain. The incidence of CPIP in our patients is less than 2%. 3D-iron loaded meshes were monitored with MRI in CPIP patients and there was no mesh-related changes found in our study. The use of MRI-visible meshes will most likely help us to monitor mesh preparations and show potential time-dependent changes in mesh characteristics and consequent complications. In case of doubtful clinical postoperative hernia recurrence or chronic groin pain, mesh position can be identified by MRI and unnecessary surgical intervention can be avoided. (Source: Hernia)
Source: Hernia - March 12, 2020 Category: Sports Medicine Source Type: research

Assessment of ideal ratio of mesh area to number of fixation tacks in laparoscopic ventral and incisional IPOM Plus hernia repair
ConclusionFor ventral and incisional hernia patients with multiple recurrence risk factors, a mesh-tack ratio MTR  ≤ 4:1 should be applied in laparoscopic IPOM Plus procedures. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - March 12, 2020 Category: Surgery Source Type: research

A prospective observational study of pediatric opioid prescribing at postoperative discharge: how much is actually used?
ConclusionThese findings confirm overprescribing of opioids to pediatric surgical patients. Families tend not to return opioids that exceed post-discharge analgesic requirements at home and many of the reported disposal methods are unsafe. We recommend future studies focus on optimizing opioid prescriptions to meet, but not excessively surpass, home pain management requirements, and to encourage safe opioid disposal/return methods.Trial registrationwww.clinicaltrials.gov (NCT03562013); registered 7 June, 2018. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - March 12, 2020 Category: Anesthesiology Source Type: research

Hemorrhagic pancreatic pseudocyst: A rare complication
Pancreatic pseudocysts are seen both in acute and chronic pancreatitis. Prevalence of pancreatic pseudocyst in chronic pancreatitis is 20% to 40% and is most commonly seen in alcoholic chronic pancreatitis. Intracystic hemorrhage from a pseudoaneurysm is a rare and potentially a lethal complication of pancreatic pseudocyst with an incidence of less than 10%. We herein present a case of a 42-year-old male with a past medical history of chronic alcoholic pancreatitis, stable pseudocyst in the tail of pancreas, alcohol abuse and seizures who presented with abdominal pain and acute anemia had this rare complication of hemorrha...
Source: The American Journal of Emergency Medicine - March 12, 2020 Category: Emergency Medicine Authors: Pujitha Kudaravalli, Nikita Garg, Venkata Satish Pendela, Harvir Singh Gambhir Source Type: research

Prevalence and Characteristics Associated with Chronic Noncancer Pain in Suicide Decedents: A National Study.
Abstract OBJECTIVE: The aims were to estimate the prevalence of CNCP in suicide decedents, and compare sociodemographic and clinical characteristics of people who die by suicide (i) with and without a history of CNCP and (ii) among decedents with CNCP who are younger (
Source: Suicide and Life-Threatening Behavior - March 12, 2020 Category: Psychiatry & Psychology Authors: Campbell G, Darke S, Degenhardt L, Townsend H, Carter G, Draper B, Farrell M, Duflou J, Lappin J Tags: Suicide Life Threat Behav Source Type: research

A prospective observational study of pediatric opioid prescribing at postoperative discharge: how much is actually used?
CONCLUSION: These findings confirm overprescribing of opioids to pediatric surgical patients. Families tend not to return opioids that exceed post-discharge analgesic requirements at home and many of the reported disposal methods are unsafe. We recommend future studies focus on optimizing opioid prescriptions to meet, but not excessively surpass, home pain management requirements, and to encourage safe opioid disposal/return methods. TRIAL REGISTRATION: www.clinicaltrials.gov (NCT03562013); registered 7 June, 2018. PMID: 32166621 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 12, 2020 Category: Anesthesiology Authors: Caldeira-Kulbakas M, Stratton C, Roy R, Bordman W, Mc Donnell C Tags: Can J Anaesth Source Type: research

Do We Have Another Option to Treat Bleeding Hemorrhoids? The Emborrhoid Technique: Experience in 16 Patients.
CONCLUSION: Our study, although small in number, demonstrates that embolization of superior rectal arteries with coils to treat severe bleeding due to hemorrhoids is safe and effective and does not lead to immediate complications. PMID: 32167429 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - March 12, 2020 Category: Cancer & Oncology Authors: Moggia E, Talamo G, Gallo G, Gallo G, Barattini M, Salsano G, Zefiro D, Stefanini T, Berti S Tags: Rev Recent Clin Trials Source Type: research

Proteomic Modulation in the Dorsal Spinal Cord Following Spinal Cord Stimulation Therapy in an In Vivo Neuropathic Pain Model
ConclusionsThe development of an injury unbalances the proteome of the local neural tissue, neurons, and glial cells, and shifts the proteomic profile to a pain producing state. This study demonstrates the reversal of the injury ‐induced proteomic state by applying conventional SCS therapy. Additional studies looking at variations in electrical parameters are needed to optimize SCS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - March 11, 2020 Category: Biotechnology Authors: Dana M. Tilley, Christopher B. Lietz, David L. Cedeno, Courtney A. Kelley, Lingjun Li, Ricardo Vallejo Tags: Basic Research Source Type: research

Analysis of Biomechanical Properties of the Lumbar Extensor Myofascia in Elderly Patients with Chronic Low Back Pain and That in Healthy People.
This study aimed to compare the biomechanical properties of the lumbar extensor myofascia in elderly patients with chronic low back pain and healthy people when resting and to analyze the relationship between the Japanese Orthopedic Association (JOA) score, visual analog scale (VAS) score, Cobb angle, and disease course and the biomechanical characteristics of the lumbar extensor myofascia. This case-control study included 40 elderly patients with chronic low back pain and 40 healthy volunteers. MyotonPRO was used to measure the biomechanical properties of the bilateral lumbar extensor myofascia (at L3/L4 level) in all par...
Source: Biomed Res - March 11, 2020 Category: Research Authors: Wu Z, Zhu Y, Xu W, Liang J, Guan Y, Xu X Tags: Biomed Res Int Source Type: research

Bilateral fibular head prominence: A case report of bilateral chronic knee pain.
Publication date: Available online 10 March 2020Source: Current Medicine Research and PracticeAuthor(s): Dr. Deepak Kumar Singhal, Dr. Brajesh Nandan, Dr. Siddharth Agrawal (Source: Current Medicine Research and Practice)
Source: Current Medicine Research and Practice - March 11, 2020 Category: General Medicine Source Type: research

Issue Cover (March 2020)
We examined its role in inflammatory pain and demonstrated that its expression changed in different neuronal subpopulations of the dorsal root ganglia at different times after cutaneous inflammation. Furthermore, this receptor wo rks co‐operatively with the type‐1 receptor for angiotensin II via regulation of the neuritogenic activity of Angiotensin II on non‐peptidergic isolectin B4 binding and peptidergic trkA‐expressing dorsal root ganglion neurons. These findings have important implications for the clinical use o f angiotensin‐II receptor blockers in the treatment of pain.Image content: Triple immunofluoresce...
Source: Journal of Neurochemistry - March 11, 2020 Category: Neuroscience Tags: Issue Cover Source Type: research

[Treatment of non-specific low back pain: Evidence map of systematic reviews from 2015 to 2019].
CONCLUSION: This evidence map provides a compact resource for the use of current systematic reviews on interventions for non-specific low back pain. The methodological deficits of many reviews require a careful approach towards their findings and conclusions and suggest a need for methodologically rigorous reviews. PMID: 32151527 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen)
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - March 11, 2020 Category: Health Management Tags: Z Evid Fortbild Qual Gesundhwes Source Type: research

Promoting an interprofessional approach to chronic pain management in primary care using Project ECHO.
Authors: Hassan S, Carlin L, Zhao J, Taenzer P, Furlan AD Abstract Chronic pain is a complex multidimensional condition that requires management with multiple professions' expertise. Healthcare training programs tend to adhere to curricula within their own profession with very few interactions with other groups. Project ECHO (Extension for Community Healthcare Outcomes) Chronic Pain and Opioid Stewardship is a model for interprofessional education, using tele-mentoring, case-base discussions and clinically focused presentations. The goal is to improve competency and confidence in managing complex cases in primary c...
Source: Journal of Interprofessional Care - March 11, 2020 Category: Health Management Tags: J Interprof Care Source Type: research

Perceptions and Impact of the 2017 Canadian Guideline for Opioid Therapy and Chronic Noncancer Pain: A Cross-Sectional Study of Canadian Physicians.
Conclusion: There was high awareness of the 2017 Canadian opioid guideline among respondents, and preliminary evidence that recommendations have changed practice to better align with the evidence. Ongoing education is required to avoid the misunderstanding that opioid tapering is mandatory, and research to identify effective strategies to manage chronic noncancer pain is urgently needed. PMID: 32148601 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - March 11, 2020 Category: Anesthesiology Authors: Busse JW, Douglas J, Chauhan TS, Kobeissi B, Blackmer J Tags: Pain Res Manag Source Type: research

Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies.
Abstract Knee osteoarthritis is a common painful degenerative condition affecting the aging Canadian population. In addition to pain and disability, osteoarthritis is associated with depression, comorbid conditions such as diabetes, and increased caregiver burden. It is predicted to cost the Canadian healthcare system $7.6 billion dollars by 2031. Despite its high cost and prevalence, controversy persists in the medical community regarding optimal therapies to treat knee osteoarthritis. A variety of medications like nonsteroidal anti-inflammatories and opioids can cause severe side effects with limited benefits. T...
Source: Pain Research and Management - March 11, 2020 Category: Anesthesiology Authors: Billesberger LM, Fisher KM, Qadri YJ, Boortz-Marx RL Tags: Pain Res Manag Source Type: research

Self-Compassion Demonstrating a Dual Relationship with Pain Dependent on High-Frequency Heart Rate Variability.
Abstract One previous study indicated the significance of trait self-compassion in psychological well-being and adjustment in people with chronic pain. Higher-frequency heart rate variability (HF-HRV) was found to be closely associated with self-compassion and pain coping. The current study was therefore designed to investigate the relationship between self-compassion and experimental pain as well as the impact of HF-HRV. Sixty healthy participants provided self-reported self-compassion and underwent a cold pain protocol during which HF-HRV was evaluated. Results demonstrated a dual relationship between self-compa...
Source: Pain Research and Management - March 11, 2020 Category: Anesthesiology Authors: Tian S, Luo X, Che X, Xu G Tags: Pain Res Manag Source Type: research

DNA Methylation May be Involved in the Analgesic Effect of Hyperbaric Oxygen via Regulating FUNDC1.
Conclusion: Our findings suggest that DNA methylation is involved in the analgesic effect of HBO via the regulation of FUNDC1. PMID: 32148597 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - March 11, 2020 Category: Anesthesiology Authors: Liu K, Wu H, Gao R, Han G Tags: Pain Res Manag Source Type: research

Editorial: The Canonical and Non-Canonical Endocannabinoid System as a Target in Cancer and Acute and Chronic Pain
(Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 11, 2020 Category: Drugs & Pharmacology Source Type: research

Time trends of major headache diagnoses and predictive factors. Data from three Nord-Tr øndelag health surveys
AbstractAimsThe primary aim of this study was to investigate time trends of major headache diagnoses using cross-sectional data from two population-based health surveys. In addition, we aimed to perform a longitudinal assessment of baseline characteristics and subsequent risk for having headache at 22-years ’ follow-up among those participating in three health surveys.MethodsData from the Nord-Tr øndelag Health Study (HUNT) performed in 1995–1997 (HUNT2), 2006–2008 (HUNT3) and 2017–2019 (HUNT4) were used. The 1-year prevalence time trends of major headache diagnoses were estimated among 41,46...
Source: The Journal of Headache and Pain - March 11, 2020 Category: Neurology Source Type: research

From an abdominal ultrasound to a lung disease passing through the diaphragm: a case of idiopathic pulmonary fibrosis
ConclusionsLung and diaphragm ultrasound could be employed as a screening or first-line diagnostic tool in the suspicion of interstitial lung disease. (Source: Journal of Ultrasound)
Source: Journal of Ultrasound - March 11, 2020 Category: Radiology Source Type: research

Stereotactic Radiofrequency Ablation of an Unresectable Intrahepatic Cholangiocarcinoma (ICC): Transforming an Aggressive Disease into a Chronic Condition
AbstractIn 2010, we reported on a 72-year-old patient with a large, unresectable cholangiocarcinoma with intrahepatic metastases, which was treated by stereotactic radiofrequency ablation (SRFA) in three consecutive sessions. Within the last nine years, the same patient has received seven additional ablation sessions for a total of ten recurrent intrahepatic lesions. One year after the last SRFA, the patient ’s liver function is still within the physiological range, suggesting that this approach is not only sufficient for locally controlling tumor disease, but also for sparing healthy tissue. Moreover, periods of hos...
Source: CardioVascular and Interventional Radiology - March 11, 2020 Category: Radiology Source Type: research

Opioid Management
This article describes a pragmatic approach to clinical care of adults with chronic pain receiving long-term opioid therapy. Three components of care are emphasized: (1) medical and mental health assessment before initiating opioid therapy, (2) clinical surveillance during the course of long-term opioid therapy, and (3) clinical considerations and strategies governing opioid tapering. A pressing need exists for ongoing research to further clarify the optimal role that long-term opioid therapy has in treatment of chronic pain. (Source: Physical Medicine and Rehabilitation Clinics of North America)
Source: Physical Medicine and Rehabilitation Clinics of North America - March 11, 2020 Category: Rehabilitation Authors: W. Michael Hooten Source Type: research

On "Short-Term Effect of Kinesiotaping on Chronic Nonspecific Low Back Pain and Disability: A Meta-Analysis of Randomized Controlled Trials." Lin S, Zhu, B. Phys Ther. 2020;100:238-254.
On "Short-Term Effect of Kinesiotaping on Chronic Nonspecific Low Back Pain and Disability: A Meta-Analysis of Randomized Controlled Trials." Lin S, Zhu, B. Phys Ther. 2020;100:238-254. Phys Ther. 2020 Mar 11;: Authors: Saueressig T PMID: 32157311 [PubMed - as supplied by publisher] (Source: Physical Therapy)
Source: Physical Therapy - March 11, 2020 Category: Physiotherapy Authors: Saueressig T Tags: Phys Ther Source Type: research

Use of Complementary Health Approaches for Chronic Low-Back Pain: A Pain Research Registry-Based Study
The Journal of Alternative and Complementary Medicine, Ahead of Print. (Source: The Journal of Alternative and Complementary Medicine)
Source: The Journal of Alternative and Complementary Medicine - March 11, 2020 Category: Complementary Medicine Authors: John C. Licciardone Vishruti Pandya Source Type: research

Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy.
Abstract Chronic fatigue syndrome, postural orthostatic tachycardia syndrome, complex regional pain syndrome and silicone implant incompatibility syndrome are a subject of debate among clinicians and researchers. Both the pathogenesis and treatment of these disorders require further study. In this paper we summarize the evidence regarding the role of autoimmunity in these four syndromes with respect to immunogenetics, autoimmune co-morbidities, alteration in immune cell subsets, production of autoantibodies and presentation in animal models. These syndromes could be incorporated in a new concept of autoimmune neur...
Source: Clinical Immunology - March 11, 2020 Category: Allergy & Immunology Authors: Shoenfeld Y, Ryabkova VA, Sheibenbogen C, Brinth L, Martinez-Lavin M, Ikeda S, Heidecke H, Watad A, Bragazzi NL, Chapman J, Churilov LP, Amital H Tags: Clin Immunol Source Type: research

One-year Results of a Factorial Randomized Trial of Aspirin versus Placebo and Clonidine versus Placebo in Patients Having Noncardiac Surgery
Conclusions Neither perioperative aspirin nor clonidine have significant long-term effects after noncardiac surgery. Perioperative aspirin in patients with previous percutaneous coronary intervention showed persistent benefit at 1 yr, a plausible sub-group effect.Editor ’s PerspectiveWhat We Already Know about This TopicThe Perioperative Ischemic Evaluation-2 study (POISE-2) authors previously reported that neither aspirin nor clonidine reduced a 30-day composite of nonfatal myocardial infarction or death. Aspirin caused perioperative bleeding, and clonidine provoked hypotension and bradycardia.In a subgroup analysis...
Source: Anesthesiology - March 10, 2020 Category: Anesthesiology Source Type: research

Cost ‐Effectiveness of Dorsal Root Ganglion Stimulation or Spinal Cord Stimulation for Complex Regional Pain Syndrome
ConclusionsDRG and SCS are cost ‐effective treatments for chronic pain secondary to CRPS‐I and II compared to CMM. DRG accrued higher cost due to higher conversion from trial to permanent implant and shorter battery life, but DRG was the most beneficial therapy due to more patients receiving permanent implants and experiencing higher quality of life compared to SCS. New DRG technology has improved battery life, which we expect to make DRG more cost‐effective compared to both CMM and SCS in the future. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - March 10, 2020 Category: Biotechnology Authors: Nagy Mekhail, Timothy R. Deer, Lawrence Poree, Peter S. Staats, Allen W. Burton, Allison T. Connolly, Edward Karst, Diana S. Mehanny, Youssef Saweris, Robert M. Levy Tags: Clinical Research Source Type: research

The Yield of Upper Gastrointestinal Endoscopy at a Pediatric Tertiary Care Center.
CONCLUSIONS: Our findings suggest a general high diagnostic yield for EGD in pediatric patients, stemming mainly from patients in whom a specific condition was suspected a priori. However, the role of the procedure in the diagnosis and management of non-specific gastrointestinal complaints was minor suggesting that EGD may be superfluous for some of these patients. PMID: 32147981 [PubMed - in process] (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - March 10, 2020 Category: General Medicine Tags: Isr Med Assoc J Source Type: research

Pilot study of a basic individualized cognitive behavioral therapy program for chronic pain in Japan
Chronic pain is a major health problem, and cognitive behavioral therapy (CBT) is its recommended treatment; however, efforts to develop CBT programs for chronic pain and assess their feasibility are remarkabl... (Source: BioPsychoSocial Medicine)
Source: BioPsychoSocial Medicine - March 10, 2020 Category: Psychiatry & Psychology Authors: Hiroki Hosogoshi, Kazunori Iwasa, Takaki Fukumori, Yuriko Takagishi, Yoshitake Takebayashi, Tomonori Adachi, Yuki Oe, Yukino Tairako, Yumiko Takao, Hiroyuki Nishie, Ayako Kanie, Masaki Kitahara, Kiyoka Enomoto, Hirono Ishii, Issei Shinmei, Masaru Horikosh Tags: Research Source Type: research