Effect of cognitive behavioural therapy on sleep and opioid medication use in adults with fibromyalgia and insomnia.
Abstract Sleep and opioid medications used to treat insomnia and chronic pain are associated with adverse side effects (falls and cognitive disturbance). Although behavioural treatments such as cognitive behavioral therapy for insomnia (CBT-I) and pain (CBT-P) improve sleep and clinical pain, their effects on sleep and opioid medication use are unclear. In this secondary analysis of published trial data, we investigated whether CBT-I and CBT-P reduced reliance on sleep/opioid medication in patients with fibromyalgia and insomnia (FMI). Patients with FMI (n = 113, Mage  = 53.0, SD = 10...
Source: Journal of Sleep Research - March 3, 2020 Category: Sleep Medicine Authors: McCrae CS, Curtis AF, Miller MB, Nair N, Rathinakumar H, Davenport M, Berry JR, McGovney K, Staud R, Berry R, Robinson M Tags: J Sleep Res Source Type: research

[Clinical application of the Bregma test : Point prevalence in healthy, pain-free and chronic pain patients and change of test results during interdisciplinary multimodal pain therapy].
CONCLUSION: Increased body perception disorders are known in chronic pain patients. The Bregma test is able to detect at least some of the patients with sensorimotor deficits. Chronic pain patients significantly differ from healthy or other patient groups. The deficits in the controllability of myofascial tissue (coordination) can also be improved during a 4-week IMST. PMID: 32125499 [PubMed - as supplied by publisher] (Source: Schmerz)
Source: Schmerz - March 3, 2020 Category: Anesthesiology Authors: Best N, Loudovici-Krug D, Zeits P, Meißner W, Smolenski UC Tags: Schmerz Source Type: research

Cyclic derivatives of morphiceptin possess anti-transit effect in the gastrointestinal tract and alleviate abdominal pain in mice.
CONCLUSIONS: Compound 1 is equally effective as P-317 in the mouse GI tract. The peptide bond reduction decreased the activity of compound 2. Fluorination appears to be an efficient way to increase the effects of morphiceptin analogs in the GI tract. PMID: 32125684 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 3, 2020 Category: Drugs & Pharmacology Authors: Szymaszkiewicz A, Włodarczyk J, Mazur M, Olczak J, Fichna J, Zielińska M Tags: Pharmacol Rep Source Type: research

Transcutaneous electrical nerve stimulation (TENS) for pain management in sickle cell disease.
CONCLUSIONS: Since we have only included one small and very low-quality trial, with a high risk of bias across several domains, we are unable to conclude whether TENS is harmful or beneficial for managing pain in people with SCD. There is a need for a well-designed, adequately-powered, RCT to evaluate the role of TENS in managing pain in people with SCD. PMID: 32124977 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 3, 2020 Category: General Medicine Authors: Pal S, Dixit R, Moe S, Godinho MA, Abas AB, Ballas SK, Ram S, Yousuf UAM Tags: Cochrane Database Syst Rev Source Type: research

Mapping patient reported outcome measures for low back pain to the International Classification of Functioning, Disability and Health using random forests.
DISCUSSION: The findings from this study are of high relevance for the further development of automatic linking programs that would allow the ICF-based classification of functioning properties within the International Classification of Diseases (ICD-11) for any health condition. Future research is needed to identify PROMs that are best suited to the automatic ICF translation process using machine learning algorithms. PMID: 32126752 [PubMed - as supplied by publisher] (Source: European Journal of Physical and Rehabilitation Medicine)
Source: European Journal of Physical and Rehabilitation Medicine - March 3, 2020 Category: Rehabilitation Authors: Tuechler K, Fehrmann E, Kienbacher T, Mair P, Fischer-Grote L, Ebenbichler G Tags: Eur J Phys Rehabil Med Source Type: research

Pain and Opioid Use After Thoracic Surgery: Where We Are and Where We Need To Go.
The objectives of this invited review are to present the findings of pertinent studies of chronic pain and opioid use after thoracic surgery, "where we are", and to discuss gaps in our knowledge of these topics and opportunities for research to fill those gaps, "where we need to go". PMID: 32142814 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - March 3, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Brown LM, Kratz A, Verba S, Tancredi D, Clauw DJ, Palmieri T, Williams D Tags: Ann Thorac Surg Source Type: research

Biology of the human blood-nerve barrier in health and disease.
Abstract A highly regulated endoneurial microenvironment is required for normal axonal function in peripheral nerves and nerve roots, which structurally consist of an outer collagenous epineurium, inner perineurium consisting of multiple concentric layers of specialized epithelioid myofibroblasts that surround the innermost endoneurium, which consists of myelinated and unmyelinated axons embedded in a looser mesh of collagen fibers. Endoneurial homeostasis is achieved by tight junction-forming endoneurial microvessels that control ion, solute, water, nutrient, macromolecule and leukocyte influx and efflux between ...
Source: Experimental Neurology - March 3, 2020 Category: Neurology Authors: Ubogu EE Tags: Exp Neurol Source Type: research

A day in the life of a chronic pain pharmacist
Once developed, chronic pain can last a lifetime, but Peter Farley, a chronic pain pharmacist, believes that there is scope to mitigate this. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - March 2, 2020 Category: Drugs & Pharmacology Source Type: research

Comparison between two dorsal capsuloplasty techniques for chronic injuries of the scapho-lunate ligament
ConclusionsBy direct comparison between the two techniques, it emerged that the modified Viegas ’ capsuloplasty was more effective than Berger’s in terms of recovery of grip strength, disability, shooting of the wrist joint (especially flexion), and correction of the carpal angles (particularly the scapho-lunate angle). We believed that the modified Viegas’ technique may be regarded as a better choice for the treatment of chronic partial lesions of the SL ligament (Geissler type III).Level of evidence: Level III, therapeutic study. (Source: European Journal of Plastic Surgery)
Source: European Journal of Plastic Surgery - March 2, 2020 Category: Cosmetic Surgery Source Type: research

Palmatine alleviates hyperalgesia by inhibiting the expression of calcitonin gene-related peptide in the trigeminal ganglion of rats with chronic constriction injury of the infraorbital nerve
Trigeminal neuralgia is one of the most common of the neuropathic pains, and it can seriously influence patients ’ quality of life. Calcitonin gene-related peptide (CGRP) is a type of nociceptive neurotransmitter that is expressed in neurons of the trigeminal ganglion and plays a major part in transmitting pain. The rat model of trigeminal neuralgia was established by causing a chronic constriction injury of the infraorbital nerve (CCI-ION). Male Sprague-Dawley rats (n=24) were randomly divided into a sham control group (sham, n=6), sham-treated with palmatine group (sham+palmatine, n=6), trigeminal nerve model group...
Source: The British Journal of Oral and Maxillofacial Surgery - March 2, 2020 Category: ENT & OMF Authors: L. He, L. Liu, S. Guan, X. Zheng, H. Ge, C. Yin, Y. Shen, M. Tan, C. Wang, Y. Gao, W. Xiong Tags: Basic Science Article Source Type: research

Correction to: Chronic Postoperative Pain After Robot-Assisted Laparoscopic Hysterectomy for Endometrial Cancer by Lunde S, Petersen KK, Kugathasan P, Arendt-Nielsen L and S øgaard-Andersen E. Journal of Gynecologic Surgery 2019;35(3);140–146. DOI: 10.1089/gyn.2018.0068
Journal of Gynecologic Surgery, Ahead of Print. (Source: Journal of Gynecologic Surgery)
Source: Journal of Gynecologic Surgery - March 2, 2020 Category: OBGYN Source Type: research

Navigating the Intersection Between Persistent Pain and the Opioid Crisis: Population Health Perspectives for Physical Therapy.
Abstract The physical therapy profession has recently begun to address its role in preventing and managing opioid use disorder (OUD). This topic calls for discussion of the scope of physical therapy practice, and the profession's role, in the prevention and treatment of complex chronic illnesses, such as OUD. OUD is not just an individual-level problem. Abundant scientific literature indicates OUD is a problem that warrants interventions at the societal level. This upstream orientation is supported in the American Physical Therapy Association's vision statement compelling societal transformation and its mission of...
Source: Physical Therapy - March 2, 2020 Category: Physiotherapy Authors: Davenport TE, DeVoght AC, Sisneros H, Bezruchka S Tags: Phys Ther Source Type: research

How Do Physical Therapists Measure Treatment Outcomes in Adults With Chronic Low Back Pain? A Systematic Review.
CONCLUSIONS: This review identified a poor overlap between the PROMIS framework and outcome domains used to define the effectiveness of physical therapy in adults with CLBP. This finding suggests that other potential benefits resulting from physical therapy modalities are not being measured. Furthermore, a large diversity in the outcome domains and instruments was found. PMID: 32115634 [PubMed - as supplied by publisher] (Source: Physical Therapy)
Source: Physical Therapy - March 2, 2020 Category: Physiotherapy Authors: Pires D, Cruz EB, Gomes LA, Nunes C Tags: Phys Ther Source Type: research

Arthroscopic Anatomical Repair of Anterior Talofibular Ligament for Chronic Lateral Instability of the Ankle: Medium- and Long-Term Functional Follow-Up.
CONCLUSION: Arthroscopic anatomical repair of ATFL for CLAI is precise, with less surgical trauma and reliable medium- and long-term effect. PMID: 32124530 [PubMed - as supplied by publisher] (Source: Hand Surgery)
Source: Hand Surgery - March 2, 2020 Category: Surgery Authors: Feng SM, Sun QQ, Wang AG, Chang BQ, Cheng J Tags: Orthop Surg Source Type: research

Corrigendum re “Extracorporeal Shock Wave Therapy for the Treatment of Chronic Pelvic Pain Syndrome in Males: A Randomised, Double-Blind, Placebo-Controlled Study” [Eur Urol 2009;56:418–24]
Publication date: Available online 29 February 2020Source: European UrologyAuthor(s): Reinhold Zimmermann, Alin Cumpanas, Florin Miclea, Günter Janetschek (Source: European Urology)
Source: European Urology - March 1, 2020 Category: Urology & Nephrology Source Type: research

A Rare Case of Cecal Bascule in a Child With Normal Neurodevelopment
We present the case of a 10-year-old boy who presented with an acute history of left lower quadrant abdominal pain, who upon investigation was found to have a cecal bascule. (Source: Pediatric Emergency Care)
Source: Pediatric Emergency Care - March 1, 2020 Category: Emergency Medicine Tags: Illustrative Cases Source Type: research

Transition From Acute to Chronic Pain in Lower Extremity Fracture Patients: A Pain Phenotyping Protocol
Conclusion This study is one of the first to longitudinally characterize the biopsychosocial variables associated with a clinically relevant problem of the transition from acute to chronic posttraumatic fracture pain in individuals with LEFx. Results from this study will be used to construct predictive risk models of physiological, psychological, and genetic/genomic variables associated with increased risk for transitioning from acute to chronic pain status after LEFx. This work will lead to a better understanding of the trajectory of pain and relevant variables over time; initiate a better understanding of variables ass...
Source: Nursing Research - March 1, 2020 Category: Nursing Tags: BRIEF REPORTS Source Type: research

Surgical Management of Primary Chronic Osteomyelitis of the Jaws: The Use of Computer-Aided-Design/Computer-Aided Manufacturing Technology for Segmental Mandibular Resection
The term osteomyelitis of the jaws identifies different pathological patterns characterized by the involvement of the cortical bone and bone marrow in osteoarticular infections. At the head and neck level, the segment most affected by osteomyelitis is the mandible and in most of the cases the cause of the infection is bacterial, as a result of pulp or periodontal infections, post-extraction alveolitis, foreign bodies and fractures. The mandibular PCO often presents with an insidious onset, without a striking acute phase, and it is characterized by recurrent episodes of pain, swelling, lockjaw, latero-cervical lymphadenopa...
Source: Journal of Craniofacial Surgery - March 1, 2020 Category: Surgery Tags: Brief Clinical Studies Source Type: research

Clinical outcomes and cost-effectiveness of massage chair therapy versus basic physiotherapy in lower back pain patients: A randomized controlled trial
Introduction: Low back pain is a chronic recurrent symptom, which can lower the patient's quality of life. With technological development of automated home massage systems, now offers a promising alternative to physiotherapy. However, thus far, the effectiveness of such methods has not been evaluated. We aimed to compare the efficacy and cost-effectiveness of a massage chair with those of conventional physiotherapy for the treatment. Methods: This was a randomized controlled trial with a two-group parallel design. Following randomization and allocation, 56 participants were enrolled to receive either physiotherapy (n...
Source: Medicine - March 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Acupuncture combined with tamsulosin hydrochloride sustained-release capsule in the treatment of chronic prostatitis/chronic pelvic pain syndrome: A study protocol for a randomized controlled trial
Discussion: This trial may provide evidence regarding the clinical effectiveness, safety, and cost-effectiveness of acupuncture for patients with CP/CPPS. Trial registration: ClinicalTrials.gov, ChiCTR1900021132, Registered on 29 January 2019 (Source: Medicine)
Source: Medicine - March 1, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Opioid Toxidrome Following Grapefruit Juice Consumption in the Setting of Methadone Maintenance
Conclusions: Grapefruit juice inhibits the metabolism of methadone, raising its serum levels. To our knowledge, this is the first reported case in which the interaction between grapefruit juice and methadone was significant enough to cause an opioid toxidrome. It is, therefore, recommended that opioid treatment programs (OTPs) advise patients about this interaction before administering methadone. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - March 1, 2020 Category: Addiction Tags: Case Reports Source Type: research

Acute and chronic neuropathic pain profiles after video-assisted thoracic surgery: A prospective study
Acute postsurgical pain, probably including acute neuropathic pain (ANeP), starts at the early postoperative period, and chronic postsurgical pain including chronic neuropathic pain (CNeP) persists at least 3 months after surgery. Although it must be important for prevention and treatment of acute and chronic postoperative pain to reveal the time course of postoperative neuropathic characteristics, a neuropathic pain profile after surgery has not been evaluated. Pain status at the surgical site in adult patients who underwent video-assisted thoracic surgery (VATS) for lung cancer was prospectively assessed until 12 months...
Source: Medicine - March 1, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Musculoskeletal Injuries and United States Army Readiness. Part II: Management Challenges and Risk Mitigation Initiatives.
CONCLUSIONS: Standardized exercise programming has reduced trainee MSKI rates. Secondary risk reduction initiatives show promise for reducing MSKI-related duty limitations and nondeployability among AC soldiers; timely identification/evaluation and appropriate, early management of MSKIs are essential. Tertiary risk reduction initiatives show promise for identifying soldiers whose chronic musculoskeletal conditions may render them unfit for continued military service.Clinicians must document MSKI care with sufficient specificity (including diagnosis and external cause coding) to enable large-scale systematic MSKI surveillan...
Source: Military Medicine - March 1, 2020 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Can Pain Management be Safely Optimized in Older Adults?
Managing chronic pain is a challenging task. Older adults (OAs) (>65 years) are the fastest growing segment of our population, and are substantially affected by chronic pain of various etiologies. Chronic pain, which affects a significant proportion of community-dwelling OAs and may be nearly universal in long-term care residents, is associated with numerous other conditions, including frailty, debility, and depression.1 Optimizing its management is critical for achieving optimal health outcomes in OAs. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 1, 2020 Category: Internal Medicine Authors: Christina Y. Chen, Brandon Verdoorn Tags: Perspective and controversy Source Type: research

Scapular Osteochondroma in a Skeletally Mature Man.
Abstract A 27-year-old man was referred to physical therapy by his primary care physician for chronic, intermittent right shoulder girdle pain. Radiographs of the shoulder were noncontributory. Examination revealed a nontender, firm mass, due to which the patient was referred back to his physician for further diagnostic testing, including scapular radiographs. Radiographs of the scapula demonstrated an osseous lesion projecting from the ventral inferior scapula. J Orthop Sports Phys Ther 2020;50(3):168. doi:10.2519/jospt.2020.9325. PMID: 32116103 [PubMed - in process] (Source: Physical Therapy)
Source: Physical Therapy - March 1, 2020 Category: Physiotherapy Authors: McClain MG, Rainey CE Tags: J Orthop Sports Phys Ther Source Type: research

Protective effects of losartan on some type 2 diabetes mellitus-induced complications in Wistar and spontaneously hypertensive rats
AbstractDiabetes mellitus type 2 (T2DM) is characterized by resistance of insulin receptors and/or inadequate insulin secretion resulting in metabolic and structural complications including vascular diseases, arterial hypertension and different behavioral alterations. We aimed to study the effects of the antihypertensive angiotensin AT1 receptor antagonist losartan on the T2DM-induced changes of exploratory behavior, anxiety, nociception and short term memory in normotensive Wistar and spontaneously hypertensive rats (SHRs). The experimental model of T2DM induced by a combination of high fat diet and streptozotocin, decrea...
Source: Metabolic Brain Disease - March 1, 2020 Category: Neurology Source Type: research

Syncope and hypermobile joints: Not rare, but rarely diagnosed.
Abstract Postural orthostatic tachycardia syndrome (POTS) is a chronic, debilitating condition characterized by heterogeneous symptoms, such as lightheadedness, palpitations, pre-syncope, syncope, and weakness or heaviness, especially of the legs. It is frequently associated with hypermobile joints or conditions such as chronic fatigue syndrome, chronic abdominal pain, migraine headache, and diabetes mellitus. Described is a case of POTS, which though it is not rare, is rarely diagnosed. It can be diagnosed quickly with simple methods. PMID: 32147649 [PubMed - in process] (Source: Turk Kardiyoloji Dernegi arsivi)
Source: Turk Kardiyoloji Dernegi arsivi - March 1, 2020 Category: Cardiology Authors: Tahirovic E Tags: Turk Kardiyol Dern Ars Source Type: research

Review/overview of pain in sickle cell disease.
Abstract Sickle cell disease (SCD) is a highly complex inherited disorder of hemoglobin structure. Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in nature causing multiple phenotypic expressions that constitute the various complications of the disease. Its manifestations could be acute, chronic, nociceptive, neuropathic that could occur singly or in various combinations. Pain continues to be the major factor of SCD phenotypic complications and the most common cause of admissions to the Emergency Department and/or the hospital. Although progress has been made in understand...
Source: Complementary Therapies in Medicine - March 1, 2020 Category: Complementary Medicine Authors: Ballas SK, Darbari DS Tags: Complement Ther Med Source Type: research

Incorporating integrative medicine and patient preferences into a pilot interdisciplinary sickle cell wellness clinic.
CONCLUSIONS: It is feasible to run a multidisciplinary clinic focused on pain management, coping skills, and healthy living with SCD. Providers benefited from the opportunity to collaborate with other disciplines. Patient and family feedback was positive, highlighted benefits of being introduced to new modalities, and reported advantages of meeting other patients/families in a new setting. PMID: 32147065 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - March 1, 2020 Category: Complementary Medicine Authors: Junghans-Rutelonis AN, Moquist KL, Blaylark RM, Anderson N, Brown ML Tags: Complement Ther Med Source Type: research

Preliminary evaluation of the clinical implementation of cognitive-behavioral therapy for chronic pain management in pediatric sickle cell disease.
CONCLUSIONS: Establishing CBT care may support reductions in admissions for pain, length of stay, and EDR for youth with chronic SCD pain, which may be partially supported by patient-reported improvements in functioning, coping, and lower pain intensity following CBT. Enhancing clinical implementation of multidisciplinary treatments may optimize the health of these youth. PMID: 32147059 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - March 1, 2020 Category: Complementary Medicine Authors: Sil S, Lai K, Lee JL, Gilleland Marchak J, Thompson B, Cohen L, Lane P, Dampier C Tags: Complement Ther Med Source Type: research

Integrating Interprofessional Case Scenarios, Allied Embedded Actors, and Teaching Into Formative Observed Structured Clinical Exams.
CONCLUSIONS: Placing interprofessional cases involving AEAs into OSCE events is easily replicated, and positively impacts students' attitudes and values in interprofessional knowledge. PMID: 32159833 [PubMed - in process] (Source: Famly Medicine)
Source: Famly Medicine - March 1, 2020 Category: Primary Care Authors: Cyr PR, Schirmer JM, Hayes V, Martineau C, Keane M Tags: Fam Med Source Type: research

PEER umbrella systematic review of systematic reviews: Management of osteoarthritis in primary care.
CONCLUSION: Interventions that provide meaningful relief for chronic osteoarthritis pain might include exercise, intra-articular corticosteroids, SNRIs, oral and topical NSAIDs, glucosamine, chondroitin, viscosupplementation, and opioids. However, funding of studies and length of treatment are important considerations in interpreting these data. PMID: 32165479 [PubMed - in process] (Source: Canadian Family Physician Medecin de Famille Canadien)
Source: Canadian Family Physician Medecin de Famille Canadien - March 1, 2020 Category: Primary Care Authors: Ton J, Perry D, Thomas B, Allan GM, Lindblad AJ, McCormack J, Kolber MR, Garrison S, Moe S, Craig R, Dugré N, Chan K, Finley CR, Ting R, Korownyk CS Tags: Can Fam Physician Source Type: research

Chronic anterior knee pain.
Abstract Palpation of the knee yielded a key diagnostic sign. PMID: 32182297 [PubMed - in process] (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - March 1, 2020 Category: Practice Management Authors: Roger C, Gouron R, Klein C Tags: J Fam Pract Source Type: research

Endovascular embolisation treatment in a rare acute abdomen spontaneous rectus sheath haematoma.
CONCLUSION: RSH is a life-threatening condition that may cause acute abdominal pain, and endovascular embolization is a safe and effective treatment option that can be applied quickly in this patient group. PMID: 32185764 [PubMed - in process] (Source: Turkish Journal of Trauma and Emergency Surgery : TJTES)
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - March 1, 2020 Category: Emergency Medicine Authors: Çakır Ç Tags: Ulus Travma Acil Cerrahi Derg Source Type: research

[Serum biomarkers in acute low back pain and sciatica].
gze N, Bereczki D Abstract Inflammation contributes to the pathogenesis of low back pain and sciatica. Growing evidence suggests that elevated levels of some inflammatory biomarkers are associated with these conditions. Much of the research evaluating the association between pro- and anti-inflammatory cytokines, chemokines, other regulatory molecules, and low back pain and sciatica, focused on patients with chronic low back pain, while fewer studies addressed the issue of detectable biomarkers in the acute phase. Previous studies suggest that pro-inflammatory cytokines such as TNF-α, IL-6, and IL-8 and anti-...
Source: Orvosi Hetilap - March 1, 2020 Category: General Medicine Authors: Dénes K, Arányi Z, Csillik A, Simó M, Debreczeni R, Tegze N, Bereczki D Tags: Orv Hetil Source Type: research

[Potential risk factors and consequences of chronic pain among Hungarian adolescents].
Conclusion: The prevalence of chronic pain, medication use and visits to physicians is considerable among Hungarian adolescents. It is an important healthcare challenge with long-term consequences until adulthood. Orv Hetil. 2020; 161(13): 502-509. PMID: 32202148 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - March 1, 2020 Category: General Medicine Authors: Godó K, Major J, Gyimesi-Szikszai A, Ádám S Tags: Orv Hetil Source Type: research

Testosterone replacement therapy of opioid induced male hypogonadism improved body composition but not pain perception. A double-blinded, randomized and placebo-controlled trial.
en M Abstract BACKGROUND: Hypogonadism is prevalent during opioid treatment, but the effect of testosterone replacement treatment (TRT) on body composition, pain perception, and adrenal function is unclear. PURPOSE: To measure changes in body composition, pain perception, quality of life and adrenal function after TRT or placebo in opioid treated men with chronic non-malignant pain. METHODS: Double-blind, placebo-controlled study in 41 men (>18 years) with total testosterone
Source: European Journal of Endocrinology - March 1, 2020 Category: Endocrinology Authors: Glintborg D, Vægter HB, Christensen LL, Bendix E, Graven-Nielsen T, Andersen PG, Andersen M Tags: Eur J Endocrinol Source Type: research

Reliability and validation of the Turkish version of the Low Back Outcome Score.
CONCLUSION: The Turkish version of the LBOS questionnaire appeared to be a valid and reliable outcome measure. LEVEL OF EVIDENCE: Level III, Diagnostic study. PMID: 32254032 [PubMed - in process] (Source: Acta Orthopaedica et Traumatologica Turcica)
Source: Acta Orthopaedica et Traumatologica Turcica - March 1, 2020 Category: Orthopaedics Authors: Alhomedah G, Çıtaker S, Günaydın G, Sezer R, Khan F Tags: Acta Orthop Traumatol Turc Source Type: research

Pain Education With Therapeutic Exercise in Chronic Nonspecific Low Back Pain Rehabilitation: A Critically Appraised Topic.
Authors: Jones KC, Tocco EC, Marshall AN, Valovich McLeod TC, Welch Bacon CE Abstract Clinical Scenario: Low back pain is widely prevalent in the general population as well as in athletes. Therapeutic exercise is a low-risk and effective treatment option for chronic pain that can be utilized by all rehabilitation clinicians. However, therapeutic exercise alone does not address the psychosocial aspects that are associated with chronic low back pain. Pain education is the umbrella term utilized to encompass any type of education to the patient about their chronic pain. Therapeutic exercise in combination with pain ed...
Source: Journal of Sport Rehabilitation - February 29, 2020 Category: Sports Medicine Tags: J Sport Rehabil Source Type: research

Issue Cover (March 2020)
Front cover:N ‐methyl‐d‐aspartate receptors (NMDARs) mediate a number of physiological and pathophysiological processes. We sought to determine if the novel NMDAR modulator NYX‐2925, discovered by Aptinyx Inc. and currently in Phase 2 clinical development for chronic pain conditions, increases glutamaterg ic neurotransmission.Image content: The rat primary hippocampal neuron depicted on the cover was treated with NYX ‐2925 at concentrations that increase synaptic levels of GluN2B‐containing NMDARs via a novel ion‐flux independent mechanism, which in turn, increases the ability of chemical long‐term potentia...
Source: Journal of Neurochemistry - February 29, 2020 Category: Neuroscience Tags: Issue Cover Source Type: research

Electroacupuncture Alleviates Experimental Chronic Inflammatory Pain by Inhibiting Calcium Voltage-Gated Channel-Mediated Inflammation.
Conclusion: We identified a few GOs, pathways, and genes that could play key roles in the amelioration of CIP by EA. Hence, this study may provide a theoretical basis for CIP amelioration by EA. PMID: 32104194 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - February 29, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The spinal microglial IL-10/ β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors
Cinobufagin is the major bufadienolide of Bufonis venenum (Chansu), which has been traditionally used for the treatment of chronic pain especially cancer pain. The current study aimed to evaluate its antinocicept... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 29, 2020 Category: Neurology Authors: Evhy Apryani, Usman Ali, Zi-Ying Wang, Hai-Yun Wu, Xiao-Fang Mao, Khalil Ali Ahmad, Xin-Yan Li and Yong-Xiang Wang Tags: Research Source Type: research

Chronic pain is common in mitochondrial disease
Mitochondrial diseases are genetic disorders caused by mutations in the mitochondrial and nuclear genomes that cause dysfunction of oxidative phosphorylation and affect approximately 1 in 5,000 people in the UK [1]. Curative treatments are currently lacking and management is largely based on symptomatic therapies and maximizing quality of life [2,3]. Pain has been reported in series of patients with mitochondrial disease, related to myopathy [4], neuropathy [5] and headache [6]. However, the prevalence, severity, impact on the quality of life and the genetic predisposition of chronic pain in this population is not fully kn...
Source: Neuromuscular Disorders - February 29, 2020 Category: Neurology Authors: Jelle van den Ameele, Joshua Fuge, Robert D.S. Pitceathly, Sarah Berry, Zoe McIntyre, Michael G. Hanna, Michael Lee, Patrick F. Chinnery Source Type: research

The Effect of Using PARO for People Living With Dementia and Chronic Pain: A Pilot Randomized Controlled Trial
To evaluate the effect of interaction with a robotic seal (PARO) on pain and behavioral and psychological symptoms of people with dementia and chronic pain. (Source: Journal of the American Medical Directors Association)
Source: Journal of the American Medical Directors Association - February 29, 2020 Category: Health Management Authors: Lihui Pu, Wendy Moyle, Cindy Jones, Michael Todorovic Tags: Original Study Source Type: research

Implementation of an Opioid Reduction Protocol for Simple Outpatient Neurosurgical Procedures: A Single-Center Experience
Study Design. Quality improvement with before and after evaluation of the intervention. Objective. To evaluate postoperative opioid utilization at a high-volume tertiary referral center following implementation of an opioid reduction protocol for simple outpatient neurosurgical procedures. Summary of Background Data. The opioid epidemic has been well-publicized both in the scientific and lay press over the last few years. As a response to this crisis many state-wide and national medical groups have sought to develop opioid prescribing guidelines for both acute and chronic pain states. Some guidelines have studied o...
Source: Spine - February 28, 2020 Category: Orthopaedics Tags: EPIDEMIOLOGY Source Type: research

Is There Equivalence Between the Electronic and Paper Version of the Questionnaires for Assessment of Patients With Chronic Low Back Pain?
Conclusion. Our findings support that the electronic version of the RMDQ, TSK, CES-D, and BPAQ can be administered in clinical and research settings for assessment of patients with chronic LBP. Nevertheless, electronic version of the NRS for assessment of pain intensity should not be used interchangeably in clinical practice in patients with chronic LBP. Level of Evidence: 3 (Source: Spine)
Source: Spine - February 28, 2020 Category: Orthopaedics Tags: HEALTH SERVICES RESEARCH Source Type: research

Systematic Administration of B Vitamins Alleviates Diabetic Pain and Inhibits Associated Expression of P2X3 and TRPV1 in Dorsal Root Ganglion Neurons and Proinflammatory Cytokines in Spinal Cord in Rats.
Conclusions: B-vitamin treatment can greatly suppress chronic DNP and DNP-associated increased activities of P2X3 and TRPV1 in DRG and the spinal proinflammatory cytokines, which may contribute to the pathogenesis of DNP. Systematic administration of B vitamins can be a strategy for DNP management in clinic. PMID: 32104520 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - February 28, 2020 Category: Anesthesiology Authors: He DD, Gao Y, Wang S, Xie Z, Song XJ Tags: Pain Res Manag Source Type: research

Improvement of bone-erosive temporomandibular joint (TMJ) abnormalities in adolescents undergoing non-surgical treatment: a longitudinal study.
Authors: Abrahamsson AK, Arvidsson LZ, Småstuen MC, Larheim TA Abstract OBJECTIVES: To investigate the longitudinal changes of the imaging TMJ characteristics in young patients with TMJ-related symptoms and treated with non-surgical methods. The severity of self-reported symptoms at follow-up was also investigated. METHODS: A cone beam computed tomography (CBCT)/CT follow-up examination (median follow-up 4.1 (1.3-6.4) years) was performed in 22 patients with erosive TMJ abnormalities (baseline median age 16 (12-18) years). Imaging characteristics were analyzed and the changes between the examinations were...
Source: Dentomaxillofacial Radiology - February 28, 2020 Category: Radiology Tags: Dentomaxillofac Radiol Source Type: research

Impact of spasticity on functioning in spinal cord injury: an application of graphical modelling.
CONCLUSION: This is the first application of graphical modelling in studying spasticity in people living with spinal cord injury. The results can be used as a basis for studies aiming to optimize rehabilitation interventions in people with moderate-to-severe spasticity. PMID: 32103278 [PubMed - as supplied by publisher] (Source: Journal of Rehabilitation Medicine)
Source: Journal of Rehabilitation Medicine - February 28, 2020 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

36: Correlation of endometriosis on preoperative MRI and surgical pathology
The aim of this study is to assess whether the use of MRI as part of preoperative workup in the setting of patients with chronic pelvic pain and presumed diagnosis of endometriosis is predictive of pathology-proven endometriosis. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 28, 2020 Category: OBGYN Authors: D. Shustarovich, M. McNeely, C. Andrew, S.A. Scheib Tags: Non-Oral Poster Source Type: research