The long-acting C5 inhibitor, ravulizumab, is efficacious and safe in pediatric patients with atypical hemolytic uremic syndrome previously treated with eculizumab
ConclusionsOverall, treatment with ravulizumab in pediatric patients with aHUS who were previously treated with eculizumab resulted in stable kidney and hematologic parameters, with no unexpected safety concerns when administered every 4 –8 weeks.Trial registrationTrial identifiers:Trial ID: ALXN1210-aHUS-312Clinicaltrials.gov: NCT03131219EudraCT number: 2016-002499-29Graphical abstract (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - February 26, 2021 Category: Urology & Nephrology Source Type: research

Support for osteopathic manipulative treatment inclusion in chronic pain management guidelines: a narrative review
CONCLUSIONS: OMT provides an evidence-based management option to reduce pain levels, improve functional status, and decrease medication usage in chronic pain conditions, especially low back pain (LBP). Pain management guidelines should include OMT as a resource to alleviate chronic pain.PMID:33635954 | DOI:10.1515/jom-2019-0284 (Source: Journal of the American Osteopathic Association)
Source: Journal of the American Osteopathic Association - February 26, 2021 Category: Complementary Medicine Authors: Megan Franzetti Emily Dries Brady Stevens Lisa Berkowitz Sheldon C Yao Source Type: research

Chronic pain syndromes: on the way to a suitable terminology and classification
Nervenarzt. 2021 Feb 26. doi: 10.1007/s00115-021-01082-4. Online ahead of print.NO ABSTRACTPMID:33635344 | DOI:10.1007/s00115-021-01082-4 (Source: Der Nervenarzt)
Source: Der Nervenarzt - February 26, 2021 Category: Neurology Authors: Constanze Hausteiner-Wiehle Casper Roenneberg Peter Henningsen Source Type: research

Effects of chronic pain on sleep quality and depression: A cross-sectional study
CONCLUSIONS: Among chronic pain patients, the high rates of poor sleep quality and depression requires a special attention. Chronic pain intensity and disability predict depression and sleep quality dimensions differently. The result underlines the need of managing poor sleep quality to address depression in the context of chronic pain.PMID:33632911 | DOI:10.15537/smj.42.3.20200768 (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - February 26, 2021 Category: Middle East Health Authors: Eman A Alhalal Ibrahim A Alhalal Amani M Alaida Sabreen M Alhweity Asma Y Alshojaa Amani T Alfaori Source Type: research

Aberrant plasticity in musculoskeletal pain: a failure of homeostatic control?
Exp Brain Res. 2021 Feb 26. doi: 10.1007/s00221-021-06062-3. Online ahead of print.ABSTRACTAberrant synaptic plasticity is hypothesised to underpin chronic pain. Yet, synaptic plasticity regulated by homeostatic mechanisms have received limited attention in pain. We investigated homeostatic plasticity in the human primary motor cortex (M1) of 21 healthy individuals in response to experimentally induced muscle pain for several days. Experimental pain was induced by injecting nerve growth factor into the muscle belly of the right extensor carpi radialis brevis muscle. Pain and disability were monitored until day 21. Homeosta...
Source: Brain Research - February 26, 2021 Category: Neurology Authors: Tribikram Thapa Thomas Graven-Nielsen Siobhan M Schabrun Source Type: research

Multicomponent synthesis and preliminary anti-inflammatory activity of lipophilic diphenylamines
In this study, we showed an efficient two-steps synthesis of diphenylamine-containing dipeptides consisting of a multicomponent process followed by a Buchwald-Hartwig cross-coupling reaction. We prepared 16 diphenylamine derivatives and evaluated their in vivo anti-inflammatory activity through an ear edema model using 12-O-tetradecanoylpholbol-13-acetate. Furthermore, the toxicity of the more potent compounds in the Artemia salina model and their cell viability using murine RAW 264.7 cells is reported. The fluorinated compound 10k becomes a reliable candidate since it reduced the TPA-induced edema to 92%, lacked cytotoxic...
Source: Bioorganic and Medicinal Chemistry Letters - February 26, 2021 Category: Chemistry Authors: Alejandra Ch ávez-Riveros Eduardo Hern ández-Vázquez Ángel Ramírez-Trinidad Antonio Nieto-Camacho Luis D Miranda Source Type: research

Bulleyaconitine A Inhibits Morphine-Induced Withdrawal Symptoms, Conditioned Place Preference, and Locomotor Sensitization Via Microglial Dynorphin A Expression
Bulleyaconitine A (BAA), a C19-diterpenoid alkaloid, has been prescribed as a nonnarcotic analgesic to treat chronic pain over four decades in China. The present study investigated its inhibition in morphine-induced withdrawal symptoms, conditioned place preference (CPP) and locomotor sensitization, and then explored the underlying mechanisms of actions. Multiple daily injections of morphine but not BAA up to 300 μg/kg/day into mice evoked naloxone-induced withdrawal symptoms (i.e., shakes, jumps, genital licks, fecal excretion and body weight loss), CPP expression, and locomotor sensitization. Single subcutaneous ...
Source: Frontiers in Pharmacology - February 26, 2021 Category: Drugs & Pharmacology Source Type: research

Clinical determinants of severe COVID-19 disease & #8211; A systematic review and meta-analysis
Conclusion: Our analysis describes the association of specific symptoms and comorbidities with severe COVID-19 disease. Knowledge of these clinical determinants will assist the clinicians in the risk-stratification of these patients for better triage and clinical management. (Source: Journal of Global Infectious Diseases)
Source: Journal of Global Infectious Diseases - February 26, 2021 Category: Infectious Diseases Authors: Ankit Kumar Sahu Roshan Mathew Praveen Aggarwal Jamshed Nayer Sanjeev Bhoi Swayamjeet Satapathy Meera Ekka Source Type: research

How to sustain and improve client centred (matched) care in chronic musculoskeletal pain? Start by changing the way policy makers select and judge the large amount of available data, and get rid of the dogma of stepped care
. (Source: European Journal of Physiotherapy)
Source: European Journal of Physiotherapy - February 26, 2021 Category: Rehabilitation Authors: Rob J. E. M. Smeets Source Type: research

Response to: ‘Efficacy and safety of duloxetine in osteoarthritis or chronic low back pain? The tip of an iceberg!’
We thank Professor Braillon for his comments1 on our article2. Although our meta-analysis was strictly consistent with the PRISMA statement3, Professor Braillon raised a number of concerns about our work. Here, we will answer each of Professor Braillon ’s questions. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - February 26, 2021 Category: Rheumatology Authors: Chenghua Weng, Zhichun Liu Tags: Letter to the Editor Source Type: research

Insights into the Use of Peripherally Acting μ-Opioid Receptor Antagonists (PAMORAs) in Oncologic Patients: from Scientific Evidence to Real Clinical Practice
Opinion statementManagement of chronic pain is crucial to improve the quality of life of cancer and palliative care patients. Opioid-based treatments used to control pain can be prolonged over time. Unfortunately, constipation is one of the most disturbing adverse effects of long-term use of opioids. Opioid-induced constipation (OIC) occurs when opioids bind to the specific receptors present in the gastrointestinal (GI) tract, and can affect any patients receiving chronic opioid therapy, including cancer patients. The limited efficacy of laxatives to treat OIC symptoms prompted the search for new therapeutic strategies. Pe...
Source: Current Treatment Options in Oncology - February 26, 2021 Category: Cancer & Oncology Source Type: research

Head and neck cancer survivors ’ pain in France: the VICAN study
ConclusionsFive years after diagnosis, pain is a very frequent sequelae that has a significant impact on quality of life in head and neck cancer survivors. Reduced physical activity, a low level of education, and tumor localization in the oropharynx are factors associated with pain.Implications for Cancer SurvivorsPain frequency and its impact on patients ’ lives imply that an adaptation must be made in terms of both pain diagnosis and management and the training of healthcare professionals.Clinical trial registration:This is not a clinical trial.ISP number: INSERM C11-63. (Source: Journal of Cancer Survivorship)
Source: Journal of Cancer Survivorship - February 26, 2021 Category: Cancer & Oncology Source Type: research

Pain Mechanisms in Patients with Rheumatic Diseases
Patients with rheumatic diseases often have mixed pain states, with varying degrees of nociceptive, neuropathic, and nociplastic mechanisms, which exist on a continuum. When individuals with any chronic pain have a nociplastic component to their symptoms, they are less likely to respond to treatments (eg, injections, surgery, biologics, and opioids) that work better for acute or purely nociceptive pain. (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - February 26, 2021 Category: Rheumatology Authors: Deeba Minhas, Daniel Joseph Clauw Source Type: research

Nonpharmacologic Pain Management in Inflammatory Arthritis
This article provides an overview of nonpharmacologic options for the treatment of pain in patients with inflammatory arthritis, such as peripheral spondyloarthritis, psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis. The experience of pain in chronic disease is a complex process influenced by multiple domains of health. The discussion focuses on the establishment of a framework for pain control that engages with factors that influence the experience of pain and explores the evidence base that supports specific modalities of nonpharmacologic pain control, such as mindfulness, cognitive behavioral therap...
Source: Rheumatic Disease Clinics of North America - February 26, 2021 Category: Rheumatology Authors: Alexander Martin, Ratnesh Chopra, Perry M. Nicassio Source Type: research

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery
CONCLUSIONS: Moderate-certainty evidence shows that paravertebral anaesthesia probably reduces PONV, hospital stay, postoperative pain (at 2 hours), and time to ambulation and results in greater patient satisfaction on the first postoperative day compared to general anaesthesia. Paravertebral anaesthesia may also reduce postoperative analgesic use and postoperative pain at 6 and 24 hours at rest and on movement based on low-certainty evidence. However, RCTs using validated questionnaires are needed to confirm these results. Adverse events observed with paravertebral anaesthesia are rare.PMID:33629404 | DOI:10.1002/14651858...
Source: Cochrane Database of Systematic Reviews - February 25, 2021 Category: General Medicine Authors: Anjolie Chhabra Apala Roy Chowdhury Hemanshu Prabhakar Rajeshwari Subramaniam Mahesh Kumar Arora Anurag Srivastava Mani Kalaivani Source Type: research

Splenoportal-mesenteric axis thrombosis and splenic artery occlusion as initial presentations of COVID-19 disease
CONCLUSIONS: A case of acute venous thrombosis and arterial occlusion as primary manifestations of COVID-19.PMID:33629338 | DOI:10.26355/eurrev_202102_24879 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 25, 2021 Category: Drugs & Pharmacology Authors: S Vidali D Morosetti A V Granai J M Legramante O C Buonomo R Argir ò Source Type: research

Therapeutic effect of Low intensity Extracorporeal Shock Wave Therapy (Li-ESWT) on diabetic bladder dysfunction in a rat model
Conclusions: Li-ESWT ameliorates the bladder dysfunction and urinary continence in the DBD rat model, reflected in restoration of the nerve expression of the urethra and the vascularization of the bladder. Non-invasive Li-ESWT could be an alternative therapeutic option for DBD.PMID:33628099 | PMC:PMC7893573 | DOI:10.7150/ijms.55274 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - February 25, 2021 Category: Biomedical Science Authors: Yung-Chin Lee Tusty-Jiuan Hsieh Fang-Hsiang Tang Jhen-Hao Jhan Kun-Ling Lin Yung-Shun Juan Hsun-Shuan Wang Cheng-Yu Long Source Type: research

An Objective Pain Score for Chronic Pain Clinic Patients
This study aims to examine the reliability and validity of an objective Chronic Pain Behavioral Pain Scale for Adults (CBPS) as compared to the traditional NRS.METHODS: In this cross-sectional study, patients were assessed before and after an interventional pain procedure by a researcher and a nurse using the CBPS and the NRS. Interrater reliability, concurrent validity, and construct validity were analyzed.RESULTS: Interrater reliability revealed a fair-good agreement between the nurse's and researcher's CBPS scores, weighted kappa values of 0.59 and 0.65, preprocedure and postprocedure, respectively. Concurrent validity ...
Source: Pain Research and Management - February 25, 2021 Category: Anesthesiology Authors: Agnes K Pace Melanio Bruceta John Donovan Sonia J Vaida Jill M Eckert Source Type: research

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery
CONCLUSIONS: Moderate-certainty evidence shows that paravertebral anaesthesia probably reduces PONV, hospital stay, postoperative pain (at 2 hours), and time to ambulation and results in greater patient satisfaction on the first postoperative day compared to general anaesthesia. Paravertebral anaesthesia may also reduce postoperative analgesic use and postoperative pain at 6 and 24 hours at rest and on movement based on low-certainty evidence. However, RCTs using validated questionnaires are needed to confirm these results. Adverse events observed with paravertebral anaesthesia are rare.PMID:33629404 | DOI:10.1002/14651858...
Source: Cochrane Database of Systematic Reviews - February 25, 2021 Category: General Medicine Authors: Anjolie Chhabra Apala Roy Chowdhury Hemanshu Prabhakar Rajeshwari Subramaniam Mahesh Kumar Arora Anurag Srivastava Mani Kalaivani Source Type: research

Splenoportal-mesenteric axis thrombosis and splenic artery occlusion as initial presentations of COVID-19 disease
CONCLUSIONS: A case of acute venous thrombosis and arterial occlusion as primary manifestations of COVID-19.PMID:33629338 | DOI:10.26355/eurrev_202102_24879 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 25, 2021 Category: Drugs & Pharmacology Authors: S Vidali D Morosetti A V Granai J M Legramante O C Buonomo R Argir ò Source Type: research

To Give or Not to Give: RhD Immunoglobulin for an < b > < i > RHD < /i > < /b > * < b > < i > 39 < /i > < /b > Pregnant Woman with Sickle Cell Disease
Conclusion: Ms. S represents a rareRHD*39 and partialRHCE*ceVS.02 genotype which did not further alloimmunize in the absence of RhIG administration. Her case also highlights the importance of routine anti-G alloantibody testing in women of childbearing age with apparent anti-D and anti-C alloantibodies.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - February 25, 2021 Category: Hematology Source Type: research

Altered interoception and its role for the co-occurrence of chronic primary pain and mental health problems in children
No abstract available (Source: Pain)
Source: Pain - February 25, 2021 Category: Anesthesiology Tags: Topical Review Source Type: research

The time course of attentional biases in pain: a meta-analysis of eye-tracking studies
Previous meta-analyses investigating attentional biases towards pain have used reaction time measures. Eye-tracking methods have been adopted to more directly and reliably assess biases, but this literature has not been synthesized in relation to pain. This meta-analysis aimed to investigate the nature and time course of attentional biases to pain-related stimuli in participants of all ages with and without chronic pain using eye-tracking studies and determine the role of task parameters and theoretically relevant moderators. After screening, 24 studies were included with a total sample of 1425 participants. Between-group ...
Source: Pain - February 25, 2021 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

The STarT Back stratified care model for nonspecific low back pain: a model-based evaluation of long-term cost-effectiveness
This study therefore produces a de novo decision model of this stratified care approach for LBP management to estimate the long-term cost-effectiveness and address methodological concerns in LBP modelling. A cost-utility analysis from the National Health Service perspective compared stratified care with usual care in patients consulting in primary care with nonspecific LBP. A Markov state-transition model was constructed where patient prognosis over 10 years was dependent on physical function achieved at 12 months. Data from the clinical trial and implementation study provided short-term model parameters, with extrapolatio...
Source: Pain - February 25, 2021 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

Patients' perceptions of the pathways linking chronic pain with problematic substance use
Approximately one-half of patients with substance use disorders (SUDs) experience chronic pain. Yet, how patients perceive the relationship between their substance use and chronic pain remains poorly understood. We sought to identify how patients with comorbid SUD and chronic pain describe the relationship between, and mechanisms linking, these conditions. We conducted qualitative interviews with 34 patients engaged in SUD treatment who were also diagnosed with chronic pain. Interviews were transcribed verbatim and coded by both primary and secondary coders. Qualitative content analysis guided coding and analysis. Patient ...
Source: Pain - February 25, 2021 Category: Anesthesiology Tags: Research Paper Source Type: research

Avoidance behaviour performed in the context of a novel, ambiguous movement increases threat and pain-related fear
The fear-avoidance model of chronic pain predicts that catastrophic (mis)interpretation of pain elicits pain-related fear that in turn may spur avoidance behaviour leading to chronic pain disability. Here, we investigated whether performing a movement to avoid a painful stimulus in the context of a novel movement increases threat and pain-related fear towards this novel movement and whether avoidance behaviour persisted when given the choice between performing the acquired movement to avoid a painful stimulus or an alternative, novel movement. Applying a robotic arm-reaching task, participants could choose between 2 moveme...
Source: Pain - February 25, 2021 Category: Anesthesiology Tags: Research Paper Source Type: research

Examination of the clinical factors associated with attendance at emergency departments for chronic pain management and the cost of treatment relative to that of other significant medical conditions
We examined ED utilisation in patients with CP, identified risk factors associated with attendance for chronic musculoskeletal pain (CMP), and estimated the comparative cost of treatment. The study cohort comprised a random sample of 3700 adults from the general population in Tayside, Scotland. Linked regional extracts, spanning a 12-month period, were obtained from national registers, providing information on ED attendances, community-dispensed prescribing, and outpatient clinic attendances. The National Health Service Scotland Cost Book was used to ascertain the current average cost of an ED attendance (£130; ∼...
Source: Pain - February 25, 2021 Category: Anesthesiology Tags: Research Paper Source Type: research

Adaptive alterations in the mesoaccumbal network after peripheral nerve injury
The nucleus accumbens (NAc) and the ventral tegmental area (VTA) are critical hubs in the brain circuitry controlling chronic pain. Yet, how these 2 regions interact to shape the chronic pain state is poorly understood. Our studies show that in mice, spared nerve injury (SNI) induced alterations in the functional connectome of D2-receptor expressing spiny projection neurons in the core region of the NAc—enhancing connections with prelimbic cortex and weakening them with basolateral amygdala. These changes, which were attributable in part to SNI-induced suppression of VTA dopaminergic signaling, were adaptive because ...
Source: Pain - February 25, 2021 Category: Anesthesiology Tags: Research Paper Source Type: research

The partial saphenous nerve injury model of pain impairs reward-related learning but not reward sensitivity or motivation
This study investigated different aspects of reward-related behaviour in a rodent model of chronic pain, the partial saphenous nerve injury (PSNI). Using our reward-learning assay, an impairment in reward learning was observed with no difference in sucrose preference, consistent with a lack of effect on reward sensitivity and similar to the effects seen in depression models. In a successive negative contrast task, chronic pain was not associated with changes in motivation for reward either under normal conditions or when reward was devalued although both sham and PSNI groups exhibited the expected negative contrast effect....
Source: Pain - February 25, 2021 Category: Anesthesiology Tags: Research Paper Source Type: research

The sociocultural context of pediatric pain: an examination of the portrayal of pain in children's popular media
This study examined how pain is portrayed and gendered in children's popular media. A cross-section of children's media targeted towards 4- to 6-year-old children was selected based on popularity, including 10 movies and the first season of 6 television shows. Pain instances were extracted and coded using 2 established observational coding systems assessing sufferer pain characteristics and observer responses (eg, empathic responses). Findings identified 454 instances of pain across the selected media. Violent pain (ie, intentionally inflicted) and injuries were most commonly represented, whereas everyday, chronic-type, an...
Source: Pain - February 25, 2021 Category: Anesthesiology Tags: Research Paper Source Type: research

What Explains Poor Health-related Quality of Life Associated With Opioid Use Among Adults With Chronic Noncancer Pain Conditions? A Blinder-Oaxaca Decomposition
The objective of this study was to estimate the extent to which differences in person-level characteristics between opioid users and nonusers contribute to poor health-related quality of life (HRQoL) of long-term opioid users with chronic noncancer pain condition (CNCP). Materials and Methods: We conducted a retrospective cohort study of adults (n=5917) using longitudinal data from multiple years of Medical Expenditure Panel Survey. Adults with CNCP were classified into short-term, long-term, and opioid nonusers. We measured HRQoL with physical component summary (PCS) and mental component summary (MCS) scores from t...
Source: Addictive Disorders and Their Treatment - February 25, 2021 Category: Addiction Tags: Original Articles Source Type: research

Personal Correlates of Support for Medical and Recreational Cannabis Legalization in Australia
Conclusions: The majority of Australians approve the legalization of cannabis for medicinal purposes but most remain cautious about legalizing recreational cannabis use. The sociodemographic and clinical profile of supporters of medical and recreational legalization suggests a potential interaction of self-interests and beliefs about the harms of cannabis use. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - February 25, 2021 Category: Psychiatry Source Type: research

Does cognitive functioning predict chronic pain in older adult? Results from the CoLaus|PsyCoLaus longitudinal study
Chronic pain (CP) affects more than 30% of people aged 65 and older, and its prevalence increases with increasing age 10. Pain in older adults is often more persistent than in younger ones 18. Regarding the cognitive domains associated with aging, the most important changes are the decrease in processing speed, working memory and executive functions 36,29. In addition, pain-related impairments in several cognitive domains including learning and memory, attention and executive function, processing speed, and psychomotor ability have been reported in various cross-sectional observational studies 2,28,7,24. (Source: The Journal of Pain)
Source: The Journal of Pain - February 25, 2021 Category: Materials Science Authors: Isabelle Rouch, Jean-Michel Dorey, Marie-Pierre F. Strippoli, Mehdi Gholam, Pedro Marques-Vidal, Bernard Laurent, Armin von Gunten, Martin Preisig Tags: Original Reports Source Type: research

Are sensory neurons exquisitely sensitive to interleukin 1 β?
AbstractPeripheral nerve injury frequently evokes chronic neuropathic pain. This is initiated by a transient inflammatory response that leads to persistent excitation of dorsal root ganglion (DRG) neurons by inflammatory cytokines such as interleukin 1 β (IL-1β). In non-neuronal cells such as lymphocytes, interleukin 1 exerts actions at attomolar (aM; 10−18 M) concentrations. We now report that DRG neurons in defined-medium, neuron-enriched culture display increased excitability following 5–6 d exposure of 1aM IL-1β. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - February 25, 2021 Category: Allergy & Immunology Authors: Patrick L. Stemkowski, Nataliya Bukhanova-Schulz, Troy Baldwin, Elena Posse de Chaves, Peter A. Smith Source Type: research

Effect of Occipital Nerve Stimulation (ONS) on the Orbicularis Oculi Reflex Triggered by a Standardized Air Flow in Patients with Chronic Migraine —A Prospective, Randomized, Interventional Study
ConclusionsThe results show that under active ONS compared to inactive ONS in patients with chronic migraine, the orbicularis oculi reflex, dynamically triggered by a standardized air flow, is significantly reduced. This suggests that ONS is able to directly counteract the trigeminally mediated central sensitization in chronic migraine and protectively reduce the effects of aversive peripheral stimulation. (Source: Pain and Therapy)
Source: Pain and Therapy - February 25, 2021 Category: Anesthesiology Source Type: research

Saliva flow rates and clinical characteristics of patients with burning mouth syndrome: A case –control study
This study examined saliva flow rates, degree of mucosal hydration, xerostomia, and clinical characteristics in BMS patients compared with healthy controls. Unstimulated whole saliva (USWS) was collected through passive drooling; residual mucosal saliva (RMS) was collected using filter paper strips. (Source: International Journal of Oral and Maxillofacial Surgery)
Source: International Journal of Oral and Maxillofacial Surgery - February 25, 2021 Category: ENT & OMF Authors: S. Werfalli, M. Drangsholt, J.M. Johnsen, S.K. Jeffrey, S. Dakhil, R.B. Presland, L. LeResche Tags: Case Control Study Source Type: research

Tapentadol, Buprenorphine, and Levorphanol for the Treatment of Neuropathic Pain: a Systematic Review
The objective of this systematic review is to present the available evidence for the utilization of the atypical opioids tapentadol, buprenorphine, and levorphanol for the treatment of neuropathic pain.Recent FindingsIn total, 1619 articles were retrieved of which 10 studies were included. Of 5 included studies pertaining to tapentadol, 4 studies show tapentadol monotherapy to be effective for the treatment of diabetic peripheral neuropathy or chronic, radiating low back pain. Of the 3 studies included for buprenorphine, only one was a randomized controlled trial found not to have a statistically significant reduction in p...
Source: Current Pain and Headache Reports - February 25, 2021 Category: Neurology Source Type: research

A Comprehensive Update of the Superior Hypogastric Block for the Management of Chronic Pelvic Pain
AbstractPurpose of ReviewThis is a comprehensive review of the superior hypogastric block for the management of chronic pelvic pain. It reviews the background, including etiology, epidemiology, and current treatment available for chronic pelvic pain. It then presents the superior hypogastric block and reviews the seminal and most recent evidence about its use in chronic pelvic pain.Recent FindingsSeveral definitions exist for chronic pelvic pain (CPP), making the diagnosis more challenging for the clinician; however, they commonly describe continuous pain lasting 6  months in the pelvis, with an overwhelming majority ...
Source: Current Pain and Headache Reports - February 25, 2021 Category: Neurology Source Type: research

Exercise in Treatment of Migraine Including Chronic Migraine
AbstractPurpose of ReviewWith this review, we aimed to investigate the effect of exercise on migraine and explored the possibility of exercise as a treatment option for migraine.Recent FindingsA close association of physical activity and exercise with migraine has been reported in clinical and population-based studies. Recent randomized controlled trials investigating the effect of aerobic exercise as a migraine-preventive treatment have revealed a notable improvement in migraine symptoms. Data on the effect of anaerobic exercise and exercise for flexibility, coordination, and relaxation on migraine are currently insuffici...
Source: Current Pain and Headache Reports - February 25, 2021 Category: Neurology Source Type: research

IJERPH, Vol. 18, Pages 2276: Cardiovascular Autonomic Control, Sleep and Health Related Quality of Life in Systemic Sclerosis
In conclusion dysautonomia and chronic pain showed a severe impact on sleep quality and disability with a consequent worsening of depressive symptom in our cohort of SSc patients. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - February 25, 2021 Category: Environmental Health Authors: Angelica Carandina Chiara Bellocchi Gabriel Dias Rodrigues Lorenzo Beretta Nicola Montano Eleonora Tobaldini Tags: Article Source Type: research

Physical Fitness and Health-related Quality of Life in Patients with Colorectal Cancer
Int J Sports Med DOI: 10.1055/a-1342-7347Colorectal cancer is now a frequently treatable illness for most and a chronic disease for many. The number of people living with a diagnosis of colorectal cancer is thus expected to rise. Yet even after successful treatment, colorectal cancer survivors, mostly the elderly, frequently experience health problems and impaired health-related quality of life. We investigated the cross-sectional association between physical fitness, measured with the 6-min walk test, 30-second chair-stand test, and isometric handgrip strength, as well as health-related quality of life, in a cohort of col...
Source: International Journal of Sports Medicine - February 25, 2021 Category: Sports Medicine Authors: Soares-Miranda, Luisa Lucia, Alejandro Silva, Marco Peixoto, Armando Ramalho, Rosa da Silva, Pedro Correia Mota, Jorge Macedo, Guilherme Abreu, Sandra Tags: Clinical Sciences Source Type: research

Chronic abdominal pain in general practice
Abstract Background and Summary. Chronic abdominal pain is a challenging complaint for both primary care providers and gastroenterologists alike, due to a broad differential diagnosis and sometimes extensive and negative workup. In the absence of red flag features that herald more acute conditions, the majority of patients with chronic abdominal pain have a benign cause or a functional disorder (e.g. Irritable bowel syndrome). The costs associated with a diagnostic workup are an expensive burden to healthcare. A systematic approach for evaluating patients and initiating a management plan are recommended in the primary car...
Source: Digestive Diseases - February 24, 2021 Category: Gastroenterology Source Type: research

Effect of Pain Education, Cryotherapy, and Transcutaneous Electrical Nerve Stimulation on the Pain, Functional Capacity, and Quality of Life in Patients With Nonspecific Chronic Low Back Pain: A Single-Blind Randomized Controlled Trial
Conclusions This study showed that with pain education, there was no difference between cryotherapy and transcutaneous electrical nerve stimulation alone, combined, or placebo mode in improving pain, functional capacity, and quality of life in patients with nonspecific chronic low back pain. (Source: American Journal of Physical Medicine and Rehabilitation)
Source: American Journal of Physical Medicine and Rehabilitation - February 24, 2021 Category: Rehabilitation Tags: Original Research Articles Source Type: research

Persistent Nerve Injury and CRPS After Ankle Sprains
A number of patients continue to experience prolonged pain, swelling, instability, and disability after a lateral ankle sprain, which is sufficient to limit their activity. There are several conditions that are misdiagnosed as chronic lateral ligament injury. In this review, we highlight common nerve conditions, with specific attention to the peroneal nerve, and chronic regional pain syndrome that can mimic chronic lateral ligament injury and can cause persistent ankle pain after lateral ankle sprain. We also offer advice for effective diagnosis and treatment of these associated pathologies. Sprained ankle syndrome, as it ...
Source: Techniques in Foot and Ankle Surgery - February 24, 2021 Category: Orthopaedics Tags: Special Focus Source Type: research

Challenges and opportunities in translational pain research – An opinion paper of the working group on translational pain research of the European pain federation (EFIC)
AbstractFor decades, basic research on the underlying mechanisms of nociception has held promise to translate into efficacious treatments for patients with pain. Despite great improvement in the understanding of pain physiology and pathophysiology, translation to novel, effective treatments for acute and chronic pain has however been limited, and they remain an unmet medical need. In this opinion paper bringing together pain researchers from very different disciplines, the opportunities and challenges of translational pain research are discussed. The many factors that may prevent the successful translation of bench observa...
Source: European Journal of Pain - February 24, 2021 Category: Anesthesiology Authors: Andr é Mouraux, Kirsty Bannister, Susanne Becker, David P. Finn, Gisèle Pickering, Esther Pogatzki‐Zahn, Thomas Graven‐Nielsen Tags: Position Paper Source Type: research

Gene expression profiling of the spinal cord at the chronic pain phase identified CDKL5 as a candidate gene for neural remodeling
Publication date: Available online 23 February 2021Source: Neuroscience LettersAuthor(s): Takashi Hozumi, Setsu Sawai, Tatsuya Jitsuishi, Keiko Kitajo, Kazuhide Inage, Yawara Eguchi, Yasuhiro Shiga, Miyako Narita, Sumihisa Orita, Seiji Ohtori, Atsushi Yamaguchi (Source: Neuroscience Letters)
Source: Neuroscience Letters - February 24, 2021 Category: Neuroscience Source Type: research

Novel approaches to develop biomarkers predicting treatment responses to TNF-blockers
Conclusions will be drawn about the possible development of predictive biomarkers for response to treatment.Expert opinion: No validated biomarker is currently available to predict treatment response in CID. New insight could be generated through the development of new bioinformatic modelling approaches to combine multidimensional biomarkers that explain the different genetic, immunological and environmental determinants of therapeutic responses.PMID:33622154 | DOI:10.1080/1744666X.2021.1894926 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - February 24, 2021 Category: Allergy & Immunology Authors: Ikram Mezghiche Hanane Yahia-Cherbal Lars Rogge Elisabetta Bianchi Source Type: research

Celiac plexus block for chronic flank pain: a case series
Can J Urol. 2021 Feb;28(1):10556-10559.ABSTRACTNon-obstructive, chronic flank pain in urologic patients can be a challenging problem to manage. In this series, we examined the efficacy of celiac plexus blockade in providing pain relief and reducing opiate use in 14 adult urology patients with non-obstructive flank pain for> 1 year. Demographic, clinical, and procedural variables were collected from the medical record for retrospective analysis. Subjective improvement in pain occurred in 11 individuals (79%), and 5 (50%) were able to reduce their daily morphine equivalent dose (MED). Celiac plexus blockade is a viable op...
Source: Canadian Journal of Urology - February 24, 2021 Category: Urology & Nephrology Authors: William W French Joseph M Kuebker Xiang Shu Christopher M Sobey Ryan S Hsi Source Type: research

Diagnosis and conservative management of great toe pathologies: a review
Postgrad Med. 2021 Feb 23. doi: 10.1080/00325481.2021.1895587. Online ahead of print.ABSTRACTAcute great toe (Hallux) pain is a common complaint encountered by the primary care physician. Pathological conditions can vary from acute trauma to acute exacerbation of underlying chronic conditions. Delay in treatment or misdiagnosis can lead to debilitating loss of function and long-lasting pain. This review endeavors to discuss the pertinent history, physical exam findings, radiographical evidence, conservative treatment options, and surgical management for the musculoskeletal causes of acute and acute on chronic great toe pai...
Source: Postgraduate Medicine - February 24, 2021 Category: Internal Medicine Authors: Nicholas A Andrews Jessyca Ray Aseel Dib Whitt M Harrelson Ankit Khurana Maninder Shah Singh Ashish Shah Source Type: research

The Role of Acupuncture on the Gut-Brain-Microbiota Axis in Irritable Bowel Syndrome
Am J Chin Med. 2021 Feb 20:1-30. doi: 10.1142/S0192415X21500154. Online ahead of print.ABSTRACTIrritable bowel syndrome (IBS) is a chronic dysfunction of the gastrointestinal tract, commonly characterized by abdominal pain or abdominal discomfort. These symptoms can substantially reduce the quality of life and work productivity of the patients. The exact pathogenesis of IBS remains unclear, as it has become apparent that multiple pathways are activated in the condition, including inflammation, immunology, neurology and psychology. Recent evidence has shown that symptoms in IBS are related to the dysfunction of the nervous ...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Kiangyada Yaklai Sintip Pattanakuhar Nipon Chattipakorn Siriporn C Chattipakorn Source Type: research