Quality of life in chronic musculoskeletal symptomatic Chilean population: secondary analysis of National Health Survey 2009 –2010
Health-related quality of life (HRQoL) is defined as the patient ’s perception of their health status. HRQoL can be modified by illnesses, treatments or social and health policies. Chronic musculoskeletal pain ... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - April 21, 2020 Category: Orthopaedics Authors: Maria Jesus Mena-Iturriaga, Manuel Vicente Mauri-Stecca, Phillip S. Sizer and Jaime Leppe Tags: Research article Source Type: research

Successful chemotherapy management of disseminated intravascular coagulation presenting with metastatic clear cell renal carcinoma: a case report and review of the literature
ConclusionsFirst, an early detection of overt disseminated intravascular coagulation is essential, although disseminated intravascular coagulation in cancer presents as a chronic or even subclinical process with unique thrombocytopenia. Second, making a decision of systemic chemotherapy without delay at the time of disseminated intravascular coagulation diagnosis is the key to successful cancer-related disseminated intravascular coagulation treatment. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 21, 2020 Category: General Medicine Source Type: research

Efficacy and safety of probiotics in irritable bowel syndrome: A systematic review and meta-analysis
Conclusion: Current evidence shows particular combinations, species or strains of probiotics are effective for overall IBS symptoms. However, it is hard to derive a definite conclusion due to high heterogeneity and unclear risk of bias of some trials. Large well-designed and rigorous trials are warranted. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - April 21, 2020 Category: Gastroenterology Authors: Jian-Rong Sun Chen-Fan Kong Xiang-Ke Qu Chao Deng Yan-Ni Lou Li-Qun Jia Source Type: research

IJERPH, Vol. 17, Pages 2842: Patient Assessment and Chronic Pain Self-Management in Ethnomedicine: Seasonal and Ecosystemic Embodiment in Ayurvedic Patient-Centered Care
Conclusions: The study highlights how circadian and seasonal cycles and evolutionary spatial-temporal factors of biogeographical and ecological regions are employed in patient assessment and self-management to support patient involvement. Recommendations for PCC in integrative chronic pain management include supporting patient ownership of their care through the dosha framework that relates the individual and the ecological in the patient’s own life-context and supports co-creation of a collaborative plan of care using an ethnomedical framework. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - April 21, 2020 Category: Environmental Health Authors: Vinita Agarwal Tags: Article Source Type: research

A physician-pharmacist collaborative care model to prevent opioid misuse.
CONCLUSION: The study demonstrated that comanagement of patients with chronic pain is feasible and acceptable. Policy changes to increase pharmacists' authority to prescribe may increase physician willingness and confidence to carry out opioid tapers and prescribe buprenorphine for pain. PMID: 32315401 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - April 21, 2020 Category: Drugs & Pharmacology Authors: Lagisetty P, Smith A, Antoku D, Winter S, Smith M, Jannausch M, Mi Choe H, Bohnert ASB, Heisler M Tags: Am J Health Syst Pharm Source Type: research

Referral patterns for temporomandibular joint disorders (TMD) in Greater Manchester.
CONCLUSION: Based on existing evidence, timely and conservative management of TMD should be encouraged in primary care, enabling better outcomes to be achieved for patients and the maintenance of the experience and skill level of specialist services in secondary care. PMID: 32306563 [PubMed - as supplied by publisher] (Source: Community Dental Health)
Source: Community Dental Health - April 20, 2020 Category: Dentistry Tags: Community Dent Health Source Type: research

FDA Considers Tanezumab Application for Chronic OA Pain
The FDA is considering an application for subcutaneous tanezumab, a monoclonal antibody, as a treatment for moderate to severe osteoarthritis... (Source: The Rheumatologist)
Source: The Rheumatologist - April 20, 2020 Category: Rheumatology Authors: Michele B. Kaufman, PharmD, BCGP Tags: Analgesics Drug Updates Chronic pain FDA osteoarthritis (OA) Pain Management tanezumab U.S. Food and Drug Administration (FDA) Source Type: research

Topical Analgesic and Local Anesthetic Agents for Pain Associated with Chronic Leg Ulcers: A Systematic Review.
Abstract GENERAL PURPOSE: To provide information about the effectiveness of topical analgesic and local anesthetic agents for reducing pain associated with chronic leg ulcers. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After participating in this educational activity, the participant will:1. Distinguish adverse reactions to topical analgesics and local anesthetic agents.2. Evaluate the effectiveness of topical analgesics and local anesthetic age...
Source: Pain Physician - April 20, 2020 Category: Anesthesiology Authors: Purcell A, Buckley T, King J, Moyle W, Marshall AP Tags: Adv Skin Wound Care Source Type: research

Suppression of peripheral NGF attenuates neuropathic pain induced by chronic constriction injury through the TAK1-MAPK/NF- κB signaling pathways
Anti-nerve growth factor (NGF) monoclonal antibodies (anti-NGF mAbs) have been reported to significantly attenuate pain, but the mechanism involved has not been fully elucidated, and the serious adverse events... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 20, 2020 Category: Molecular Biology Authors: Wen-Ling Dai, Bing Yan, Yi-Ni Bao, Ji-Fa Fan and Ji-Hua Liu Tags: Research Source Type: research

Women, addiction, and grief: A quality improvement initiative
Considerable research has been conducted identifying risk factors associated with substance abuse disorders (SUD) in women. These factors include psychological and emotional distress, domestic violence, sexual abuse, weight control, fighting exhaustion, and chronic pain (NIDA: https://www.drugabuse.gov/publications/drugfacts/substance-use-in-women). Another risk factor, and common experience among substance abusing women, is the death of a family member and unresolved grief (Furr, Johnson,& Goodall, 2015; Horton, Luna,& Malloy, 2018; McComish et al., 1999; Raskin, 1992). (Source: Archives of Psychiatric Nursing)
Source: Archives of Psychiatric Nursing - April 20, 2020 Category: Nursing Authors: Carla J. Groh, Jasmina Cunmulaj Source Type: research

Effects of an Individualized Comprehensive Rehabilitation Program on impaired postural control in women with chronic pelvic pain: a randomized controlled trial
To assess the effectiveness of an Individualized Comprehensive Rehabilitation Program (ICPR) on impaired postural control, pain, self-perceived health status and functionality in women with CPP. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - April 20, 2020 Category: Rehabilitation Authors: Janet Rodr íguez-Torres, Laura López-López, Irene Cabrera-Martos, Esther Prados-Román, María Granados Santiago, Marie C. Valenza Source Type: research

A Systematic Review of Economic Evaluations Reporting the Cost-Effectiveness of Spinal Cord Stimulation
Spinal cord stimulation (SCS) is a recognized treatment for chronic pain. This systematic review aims to assess economic evaluations of SCS for the management of all chronic pain conditions, summarize key findings, and assess the quality of studies to inform healthcare resource allocation decisions and future research. (Source: Value in Health)
Source: Value in Health - April 20, 2020 Category: International Medicine & Public Health Authors: Siwaporn Niyomsri, Rui V. Duarte, Sam Eldabe, Gregory Fiore, Brian H. Kopell, Ewan McNicol, Rod S. Taylor Tags: Systematic Literature Review Source Type: research

Lifting capacity is associated with central sensitization and non-organic signs in patients with chronic back pain.
Abstract Purpose: To analyze the associations between lifting capacity, and central sensitization (CS) and non-organic signs (NOS) in patients with chronic back pain (CBP) attending vocational rehabilitation.Materials and methods: Cross-sectional observational multicenter study among patients with CBP undergoing a return to work assessment within care as usual. Main analyses: step 1: partial correlation between lifting capacity, and CS, NOS, and additional variables; step 2: multiple regression in stepwise forward method for dependent variable lifting capacity, and for independent variables CS and NOS, and additio...
Source: Disability and Rehabilitation - April 20, 2020 Category: Rehabilitation Authors: Ansuategui Echeita J, van der Wurff P, Killen V, Dijkhof MF, Grootenboer FM, Reneman MF Tags: Disabil Rehabil Source Type: research

Mindfulness meditation is related to sensory ‐affective uncoupling of pain in trained novice and expert practitioners
ConclusionThese findings suggest that mindfulness meditation specifically down ‐regulates pain affect as opposed to pain intensity, and that pain catastrophizing undermines sensory‐affective uncoupling of pain.SignificanceIn this study, we found that a style of mindfulness meditation referred to as Open Monitoring reduced unpleasantness but not intensity ratings compared to attentional distraction in trained novice (state effect) and expert meditators (state and trait effects). We also observed that trait pain catastrophizing scores predicted this sensory ‐affective uncoupling. These findings advance our understandin...
Source: European Journal of Pain - April 20, 2020 Category: Anesthesiology Authors: Jelle Zorn, Oussama Abdoun, Romain Bouet, Antoine Lutz Tags: ORIGINAL ARTICLE Source Type: research

Evaluation of botulinum toxin A injections for the treatment of refractory chronic digital ulcers in patients with systemic sclerosis.
CONCLUSIONS: BTX-A injections might be of benefit for the treatment of chronic, refractory DU in selected SSc patients, yet a sufficiently powered prospective study will be needed as ultimate proof. PMID: 32301424 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Pharmacotherapeutic Options for Chronic Refractory Cough.
Authors: Song WJ, Chung KF Abstract Introduction: Chronic refractory cough (CRC) is more than a persistent cough, but can cause serious impairment to quality of life. Through remarkable advances in our understanding of the neurobiology of cough, there is realization that CRC can be controlled by novel drugs that target cough reflex pathways.Areas covered: The authors present an overview of the clinical trials of antitussives for CRC, and ongoing clinical trials of novel drugs. They discuss the potential strengths and limitations of each medication, as well as knowledge gaps and uncertainties that should be addresse...
Source: Expert Opinion on Pharmacotherapy - April 19, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

"We have two different agendas": the views of general practitioners, social workers and hospital staff on interprofessional coordination for patients with chronic widespread pain.
"We have two different agendas": the views of general practitioners, social workers and hospital staff on interprofessional coordination for patients with chronic widespread pain. J Interprof Care. 2020 Apr 16;:1-9 Authors: Schultz R, Brostrøm Kousgaard M, Davidsen AS Abstract Patients with chronic widespread pain (CWP) are often unfit for work and go through lengthy treatment. In Denmark, this includes contacts with the job center in their municipality, their general practitioner (GP) and one or more hospital units. Little is known about how coordination around patients with CWP funct...
Source: Journal of Interprofessional Care - April 18, 2020 Category: Health Management Tags: J Interprof Care Source Type: research

Macrophages and Schwann cell TRPA1 mediate chronic allodynia in a mouse model of complex regional pain syndrome type I
Publication date: Available online 18 April 2020Source: Brain, Behavior, and ImmunityAuthor(s): Francesco de Logu, Samira Dal-Toé De Prá, Caren Tatiane de David Antoniazzi, Sabrina Qader Kudsi, Paula Ronsani Ferro, Lorenzo Landini, Flávia Karine Rigo, Gustavo de Bem Silveira, Paulo Cesar Lock Silveira, Sara Marchesan Oliveira, Matilde Marini, Gianluca Mattei, Juliano Ferreira, Pierangelo Geppetti, Romina Nassini, Gabriela Trevisan (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 18, 2020 Category: Neurology Source Type: research

Platelet-rich plasma injection in a patient with adhesive capsulitis due to chronic kidney disease.
Authors: Bölük Şenlikci H, İkbali Afşar S, Özen S Abstract Adhesive capsulitis is a common problem in patients with chronic kidney disease. Patients suffer from joint stiffness and painful joint movement.Conservative treatments consist non-steroid antiinflamatory drugs, intraarticular injections and physical therapy. Newer approches such as platelet-rich plasma injections (PRP) also can be applied but there is little evidence for the effectiveness of PRP in patients with adhesive capsulitis. A 70 year-old woman, receives dialysis treatment admitted to our out-patient clinic with stiffness and pain...
Source: Agri Dergisi - April 18, 2020 Category: Anesthesiology Tags: Agri Source Type: research

Comparison of epidural and intravenous route for acute and chronic postoperative pain control in patients with gynecological malignancy.
CONCLUSION: The results showed that epidural and intravenous analgesia had a similar effect regarding the chronicity of pain but better outcomes were achieved with epidural analgesia in the acute stage. PMID: 32297961 [PubMed - in process] (Source: Agri Dergisi)
Source: Agri Dergisi - April 18, 2020 Category: Anesthesiology Tags: Agri Source Type: research

Are non-invasive brain stimulation techniques effective in the treatment of chronic pain? - A Cochrane Review Summary with commentary.
Authors: Cecchi F Abstract Missing (Cochrane Corner). PMID: 32300814 [PubMed - in process] (Source: Journal of Rehabilitation Medicine)
Source: Journal of Rehabilitation Medicine - April 18, 2020 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Interdisciplinary approach to chronic pain management.
Authors: Alexey D, Andrey D, Aleksander B, Olga K, Nina L Abstract Chronic pain is a significant and costly problem all over the world. Despite significant progress in identifying the best treatment approaches, there are still significant obstacles that must be overcome in order for the treatment to be truly beneficial. There is evidence to support the cost-effectiveness of interdisciplinary treatment programs for patients with chronic pain. Creating an interdisciplinary service is not easy and certainly is much more complicated than simply placing different services in one clinic. However, when such interdisciplin...
Source: Postgraduate Medicine - April 18, 2020 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Cannabis for Symptom Management in Older Adults
This article provides an overview of the evidence on the risks and benefits of using medical cannabis for the indications of chronic pain, cancer-related pain, cancer cachexia, dementia, and Alzheimer ’s disease. Currently, there is insufficient evidence to determine the effectiveness and safety of cannabinoids for most reviewed indications, with the exception of chronic pain. Future research is required before palliative care clinicians can make evidence-based decisions on the integration of m edical cannabis as adjunct therapies. (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - April 18, 2020 Category: Primary Care Authors: Cari Levy, Emily Galenbeck, Kate Magid Source Type: research

GSE148835 Identification of genetic biomarker signatures associated with cannabis pharmacokinetics and tolerability
This study is aimed at identifying a genetic signature that is predictive of the pharmacokinetics of tetrahydrocannabinol (THC), the principal intoxicating chemical compound derived from cannabis. We have identified 55 variants among 38 genes that were overrepresented in either the Low-THC or High-THC groups. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 18, 2020 Category: Genetics & Stem Cells Tags: SNP genotyping by SNP array Homo sapiens Source Type: research

Macrophages and Schwann cell TRPA1 mediate chronic allodynia in a mouse model of complex regional pain syndrome type I.
Trevisan G Abstract Complex regional pain syndrome type I (CRPS-I) is characterized by intractable chronic pain. Poor understanding of the underlying mechanisms of CRPS-I accounts for the current unsatisfactory treatment. Antioxidants and antagonists of the oxidative stress-sensitive channel, the transient receptor potential ankyrin 1 (TRPA1), have been found to attenuate acute nociception and delayed allodynia in models of CRPS-I, evoked by ischemia and reperfusion (I/R) of rodent hind limb (chronic post ischemia pain, CPIP). However, it is unknown how I/R may lead to chronic pain mediated by TRPA1. Here, we rep...
Source: Brain, Behavior, and Immunity - April 18, 2020 Category: Neurology Authors: de Logu F, Dal-Toé De Prá S, Tatiane de David Antoniazzi C, Qader Kudsi S, Ronsani Ferro P, Landini L, Karine Rigo F, de Bem Silveira G, Cesar Lock Silveira P, Marchesan Oliveira S, Marini M, Mattei G, Ferreira J, Geppetti P, Nassini R, Trevisan G Tags: Brain Behav Immun Source Type: research

Analgesic and side effects of intravenous recombinant Phα1β
Conclusion: Our data suggest that intravenous administration of recombinant Ph α 1 β may be feasible for drug-induced analgesia, without causing any severe side effects. (Source: Journal of Venomous Animals and Toxins including Tropical Diseases)
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - April 17, 2020 Category: Tropical Medicine Source Type: research

Consequences of Chronic Non-Cancer Pain in adulthood. Scoping Review.
CONCLUSIONS This review shows that limitations in the ability to perform activities of daily living, sleep, psychological health, social and work resources and family functioning are lines of interest in published articles. However, knowledge gaps are detected in areas such as the influence of having suffered pain in childhood or adolescence, the consequences of non-fulfillment of working hours and gender inequalities.RESUMEN OBJETIVO Examinar y mapear las consecuencias del dolor cr ónico en la edad adulta. MÉTODO Se incluyeron documentos que abordaban las repercusiones del dolor crónico en las esferas...
Source: Revista de Saude Publica - April 17, 2020 Category: International Medicine & Public Health Source Type: research

Quality of Life in Women with Deep Endometriosis: A Cross-Sectional Study
Conclusion Although clinically treated, women with deep endometriosis present impairment in different domains of quality of life regardless of the questionnaire used for evaluation.Resumo Objetivo Descrever caracter ísticas clínicas e sociodemográficas de mulheres com endometriose profunda infiltrativa e avaliar sua qualidade de vida dentro de 6 meses de tratamento clínico. Métodos Estudo de corte transversal descritivo com 60 mulheres em seguimento ambulatorial na Universidade de Campinas, Campinas, SP, Brasil, com endometriose profunda infiltrativa diagnosticada por cirurgia ou mé...
Source: Revista Brasileira de Ginecologia e Obstetricia - April 17, 2020 Category: OBGYN Source Type: research

A multi ‐center international study of Acupuncture for lateral elbow pain ‐ Results of a randomized controlled trial
ConclusionsAcupuncture was shown to be efficacious in improving the function of the arm associated with lateral elbow tendinosis. Both the DASH score and the VAS pain on two occasions (at rest and during motion) showed a significant change over time indicating acupuncture as a potential treatment for LEP due to tendinosis. (Source: European Journal of Pain)
Source: European Journal of Pain - April 17, 2020 Category: Anesthesiology Authors: Marcus Gadau, Shi Ping Zhang, Fu Chun Wang, Stefano Liguori, Christopher Zaslawski, Wei Hong Liu, Sergio Bangrazi, Christine Berle, Shohreh Razavy, Zhao Xiang Bian, Petti Filomena, Yang Hao, Hai Lin Jiang, Li Lei, Tie Li, Wei Hong Li, Aldo Tags: ORIGINAL ARTICLE Source Type: research

MR-Guided Focused Ultrasound Central Lateral Thalamotomy for Trigeminal Neuralgia. Single Center Experience
Conclusion: Our study provides preliminary support for the safety and efficacy of MRgFUS CLT, a histologically and pathophysiologically based medial thalamotomy against chronic therapy-resistant trigeminal neuralgia. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - April 17, 2020 Category: Neurology Source Type: research

Spinal cord injury is not a feature of chronic whiplash-associated disorder: a magnetic resonance spectroscopy study
This study aimed to assess metabolite concentrations indicative of neuronal injury or pathology in the cervical cord in people with chronic WAD.MethodsForty-one people with chronic WAD (mean [SD] age 39.6 [11.0] years, 25 females) and 14 healthy controls (39.2 [12.6] years, 9 females) underwent cervical spinal cord magnetic resonance spectroscopy to measure the metabolitesN-acetylaspartate (NAA), creatine (Cr) and choline (Cho). Participants with WAD completed clinical questionnaires on pain intensity (Visual Analogue Scale), disability (Neck Disability Index) and psychological factors (Pain Catastrophising Scale, Post-tra...
Source: European Spine Journal - April 17, 2020 Category: Orthopaedics Source Type: research

Stem Cell Therapies for the Treatment of Diabetic Neuropathies: Future Perspectives.
CONCLUSION: In the present review, we attempt to discuss the potential of most studied types of stem cells, their application for the treatment of experimental diabetic neuropathies and associated clinical manifestations including future perspectives around these themes. PMID: 32303173 [PubMed - as supplied by publisher] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - April 17, 2020 Category: Endocrinology Authors: de Figueiredo CS, Dos Reis LC Tags: Curr Diabetes Rev Source Type: research

Inhibition of P2X7R in the amygdala ameliorates symptoms of neuropathic pain after spared nerve injury in rats.
This study aims to evaluate the alleviative effect of intra-amygdala microinfusion of a pharmacological antagonist of P2X7R (A-438079) on NP and explore its possible mechanism of action. Male Sprague-Dawley rats were used to construct the animal model of NP through spared nerve injury (SNI). The SNI rats randomly received chronic bilateral microinjection of A-438079 (100 pmol/side) or saline into the amygdalae via cannulas. Mechanical paw withdrawal threshold (MWT) and thermal withdrawal duration (TWD) were measured by von Frey monofilaments. Besides, tail suspension test (TST), forced swimming test (FST), open field test ...
Source: Brain, Behavior, and Immunity - April 17, 2020 Category: Neurology Authors: Hu X, Liu Y, Wu J, Liu Y, Liu W, Chen J, Yang F Tags: Brain Behav Immun Source Type: research

Direct Impact of Motor Cortical Stimulation on the Blood Oxygen-level Dependent Response in Rats.
CONCLUSION: By conducting direct cortical stimulation of the rodent brain to investigate its instant effect using fMRI, we identified encephalic regions directly involved in the instant motor cortical stimulation effects in healthy rat models. This result may be essential in establishing a foundation for further research on the underlying neuropathways associated with the MCS effects. PMID: 32307360 [PubMed - as supplied by publisher] (Source: Magnetic Resonance in Medical Sciences : MRMS)
Source: Magnetic Resonance in Medical Sciences : MRMS - April 17, 2020 Category: Radiology Authors: Xin Z, Abe Y, Liu S, Tanaka KF, Hosomi K, Saitoh Y, Sekino M Tags: Magn Reson Med Sci Source Type: research

The perceptions, barriers, and enablers to physical activity and minimising sedentary behaviour among Arab-Australian adults aged 35 to 64 years.
CONCLUSIONS: This study highlighted the factors that influence the PA levels and sedentary behaviour of Arab-Australian adults aged 35-64 years. SO WHAT?: The findings of this study could help inform the design and development of culturally-tailored PA interventions for Arab-Australian adults. PMID: 32291855 [PubMed - as supplied by publisher] (Source: Health Promotion Journal of Australia)
Source: Health Promotion Journal of Australia - April 16, 2020 Category: International Medicine & Public Health Tags: Health Promot J Austr Source Type: research

Minimally Invasive Decompression with Posterior Elements Preservation Versus Laminectomy and Fusion For Lumbar Degenerative Spondylolisthesis: A Systematic Review and Meta-Analysis of Surgical, Clinical and Radiological Outcomes.
CONCLUSIONS: This meta-analysis suggests that MID might be considered as an effective alternative to LF for DS. Further clinical trials will be needed to confirm our results, better investigate radiological outcomes, and identify patient subgroups that may benefit the most from specific techniques. PMID: 32294225 [PubMed - as supplied by publisher] (Source: Surgical Technology International)
Source: Surgical Technology International - April 16, 2020 Category: Surgery Tags: Surg Technol Int Source Type: research

Occurrence and Risk Factors of Chronic Pain After Critical Illness
Conclusions: Newly-acquired chronic pain is a frequent consequence of critical illness, and its impact on daily life of affected patients is substantial. (Source: Critical Care Medicine)
Source: Critical Care Medicine - April 16, 2020 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Microbiota composition and distribution along the female reproductive tract of women with endometriosis
Endometriosis (EMS) is a multifactorial disease that affects 10% –15% women of reproductive age and is associated with chronic pelvic pain and infertility. The pathogenesis of EMS has not been consistently expl... (Source: Annals of Clinical Microbiology and Antimicrobials)
Source: Annals of Clinical Microbiology and Antimicrobials - April 16, 2020 Category: Microbiology Authors: Weixia Wei, Xiaowei Zhang, Huiru Tang, Liping Zeng and Ruifang Wu Tags: Research Source Type: research

Combined extracorporeal shock wave lithotripsy and endoscopic treatment for pain in chronic pancreatitis (SCHOKE trial): study protocol for a randomized, sham-controlled trial
Pain is the primary symptom of chronic pancreatitis (CP) and remains a considerable therapeutic challenge. In patients with obstruction of the pancreatic duct, including stones and strictures, endoscopic treat... (Source: Trials)
Source: Trials - April 16, 2020 Category: General Medicine Authors: S øren S. Olesen, Asbjørn M. Drewes, Rajesh Gaud, Manu Tandan, Sundeep Lakhtakia, Mohan Ramchandani, G. V. Rao, D. Nageshwar Reddy and Rupjyoti Talukdar Tags: Study protocol Source Type: research

The ProFitMap-Neck - A Questionnaire for Measuring Symptoms and Functional Limitations in Neck Pain: Reliability, Validity and Cross-Cultural Adaptation of the Turkish version.
CONCLUSION: The ProFitMap-neck is an evaluation instrument with sufficient validity and reliability to be used for evaluating Turkish patients with neck pain. Use of this scale can reveal how, how often, and how much these patients? pain affects their symptoms and functional activities. PMID: 32283891 [PubMed - as supplied by publisher] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - April 16, 2020 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Body awareness and chronic low back pain: validity and reliability study of Turkish version of Body Awareness Rating Scale.
Authors: Demirel A, Onan D, Özel Asliyüce Y, Öz M, Berberoğlu U, Ülger Ö Abstract Body awareness and chronic low back pain: validity and reliability study of Turkish version of Body Awareness Rating Scale Background/aim: Previous studies reported that patients with chronic low back pain (CLBP) had trouble describing senses or body functions. A questionnaire, the Body Awareness Rating Questionnaire (BARQ), was recently developed for assessing body awareness. The aim of the study was to develop a Turkish version of the BARQ and investigate the validity and reliability in patients with CLBP. ...
Source: Turkish Journal of Medical Sciences - April 16, 2020 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Chronic Post-Surgical Pain in the Frail Older Adult
AbstractOlder adults are the fastest growing segment of the population and surgical procedures in this group increase each year. Chronic post-surgical pain is an important consideration in the older adult as it affects recovery, physical functioning, and overall quality of life. It is increasingly recognized as a public health issue but there is a need to improve our understanding of the disease process as well as the appropriate treatment and prevention. Frailty, delirium, and cognition influence post-operative outcomes in older adults and have been implicated in the development of chronic post-surgical pain. Further rese...
Source: Drugs and Aging - April 16, 2020 Category: Geriatrics Source Type: research

Pelvic Floor Dysfunction in Women
AbstractPurpose of ReviewThe purpose of this review is to give an overview of pelvic floor muscle (PFM) dysfunction in women including evaluation, diagnosis, and treatment.Recent FindingsThe prevalence of PFM dysfunction is thought to be higher in women and may contribute to urinary, defecatory, and sexual dysfunction, as well as chronic pelvic pain.SummaryPFM dysfunction is more prevalent amongst athletes, women who have given birth, and postmenopausal women than the general population. Stress and urge incontinence, urinary frequency and urgency, functional constipation, and fecal incontinence are all symptoms that may re...
Source: Current Physical Medicine and Rehabilitation Reports - April 16, 2020 Category: Rehabilitation Source Type: research

Abdominal erythema ab igne —An "old" finding revisited
Abdominal erythema ab igne may be the result of insufficient pain medication in chronic pancreatitis. Stenting therapy is to be considered, and the patient should be informed about the risk of developing cutaneous squamous or Merkel cell carcinoma. AbstractAbdominal erythema ab igne may be the result of insufficient pain medication in chronic pancreatitis. Stenting therapy is to be considered, and the patient should be informed about the risk of developing cutaneous squamous or Merkel cell carcinoma. (Source: Clinical Case Reports)
Source: Clinical Case Reports - April 16, 2020 Category: General Medicine Authors: Igor Alexander Harsch Tags: CLINICAL IMAGE Source Type: research

Colocolic intussusception secondary to submucosal lipoma
We report a case of chronic colocolic intussusception secondary to a lead point submucosal lipoma. Dedifferentiating intussusception with or without a lead point is important in determining appropriate management. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - April 16, 2020 Category: Emergency Medicine Authors: Isaac Boyack, David Vu, Pratik Patel, Oleg Opsha Source Type: research

Non-steroidal anti-inflammatory drugs for acute low back pain.
CONCLUSIONS: This updated Cochrane Review included 32 trials to evaluate the efficacy of NSAIDs in people with acute LBP. The quality of the evidence ranged from high to very low, thus further research is (very) likely to have an important impact on our confidence in the estimates of effect, and may change the estimates. NSAIDs seemed slightly more effective than placebo for short-term pain reduction (moderate certainty), disability (high certainty), and global improvement (low certainty), but the magnitude of the effects is small and probably not clinically relevant. There was no clear difference in short-term pain reduct...
Source: Cochrane Database of Systematic Reviews - April 16, 2020 Category: General Medicine Authors: van der Gaag WH, Roelofs PD, Enthoven WT, van Tulder MW, Koes BW Tags: Cochrane Database Syst Rev Source Type: research

The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis.
Abstract Corticosteroid associated osteonecrosis is bone death resulting from the use of chronic glucocorticoids and most commonly affects the femoral head, although the bones such as around knee joint, wrist joint and ankle joint can be affected. The pathogenesis is likely multifactorial, with genetic and environmental factors playing a role. Epigenetics may be the mechanism by which environment exerts it effects. In spite of recent discoveries, the exact pathogenesis of corticosteroid associated osteonecrosis is unknown. Over the past few years, more miRNA's have been found to be associated with osteonecrosis. T...
Source: Journal of Autoimmunity - April 16, 2020 Category: Allergy & Immunology Authors: Chang C, Greenspan A, Gershwin ME Tags: J Autoimmun Source Type: research

Ustekinumab in the treatment of patients with hidradenitis suppurativa: multicenter case series and systematic review.
Conclusion: These findings suggest that ustekinumab may be an effective and safe option for patients with HS who fail to respond to first-line therapies. PMID: 32279593 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 15, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A Central Amygdala –Ventrolateral Periaqueductal Gray Matter Pathway for Pain in a Mouse Model of Depression-like Behavior
Background The mechanisms underlying depression-associated pain remain poorly understood. Using a mouse model of depression, the authors hypothesized that the central amygdala –periaqueductal gray circuitry is involved in pathologic nociception associated with depressive states.Methods The authors used chronic restraint stress to create a mouse model of nociception with depressive-like behaviors. They then used retrograde tracing strategies to dissect the pathway from the central nucleus of the amygdala to the ventrolateral periaqueductal gray. The authors performed optogenetic and chemogenetic experiments to manipul...
Source: Anesthesiology - April 15, 2020 Category: Anesthesiology Source Type: research

Synaptic Dynamics of the Feed-forward Inhibitory Circuitry Gating Mechanical Allodynia in Mice
Background The authors ’ previous studies have found that spinal protein kinase C γ expressing neurons are involved in the feed-forward inhibitory circuit gating mechanical allodynia in the superficial dorsal horn. The authors hypothesize that nerve injury enhances the excitability of spinal protein kinase C γ express ing interneurons due to disinhibition of the feed-forward inhibitory circuit, and enables Aβ primary inputs to activate spinal protein kinase C γ expressing interneurons.MethodsPrkcg-P2A-tdTomato mice were constructed using the clustered regularly interspaced short palindromic rep...
Source: Anesthesiology - April 15, 2020 Category: Anesthesiology Source Type: research