Heterogeneity of treatment effects in a randomized trial of literacy-adapted group cognitive-behavioral therapy, pain psychoeducation, and usual medical care for multiply disadvantaged patients with chronic pain
Chronic pain affects over 100 million American adults, costing up to $635 billion annually.27,28 Although recent advances have increased our understanding of treatment efficacy for chronic pain, about 40% of individuals report inadequate pain relief.7 Many individuals suffer from the negative effects of chronic pain, such as frequent absence from work and unemployment,6,19 limitations in physical activities,54 disability,47 decreased social interactions and/or perceived support,9,12 depression35 and anxiety. (Source: The Journal of Pain)
Source: The Journal of Pain - April 22, 2019 Category: Materials Science Authors: Benjamin P. Van Dyke, Andrea K. Newman, Calia A. Mora ís, John W. Burns, Joshua C. Eyer, Beverly E. Thorn Source Type: research

Oxytocin Effects on Pain Perception and Pain Anticipation
Searching for new analgesics there is an ongoing debate whether the hypothalamic neuropeptide oxytocin (OT) has a modulatory effect on pain processing. Strong evidence for an analgesic property of OT comes from rodents, where OT was shown to act in several regions of the pain matrix with the ventral striatum (VS) being identified as a main target region of antinoiceptive OT effects 14, 44. OT may also exert effects on pain anticipation since a specific subpopulation of OT neurons was found to be activated during pain anticipation in rodents (V. (Source: The Journal of Pain)
Source: The Journal of Pain - April 19, 2019 Category: Materials Science Authors: Sabine C. Herpertz, Mike M. Schmitgen, Christine Fuchs, Corinna Roth, Robert Christian Wolf, Katja Bertsch, Herta Flor, Valery Grinevich, Sabrina Boll Source Type: research

Adverse Childhood Experiences in Mothers with Chronic Pain and Intergenerational Impact on Children
Exposure to adverse childhood experiences (ACEs) (e.g. abuse, neglect, parental divorce, etc.) has been linked to a number of poor physical and mental health outcomes in adulthood.12 These poor health outcomes often include multiple somatic symptoms, chronic pain, depression and anxiety.9, 28, 42 In a study examining ACE prevalence in childhood, and risk of frequent headaches in adulthood, researchers found that as ACE scores increased, the prevalence and risk of headaches increased significantly. (Source: The Journal of Pain)
Source: The Journal of Pain - April 18, 2019 Category: Materials Science Authors: Catlin H. Dennis, Denae S. Clohessy, Amanda L. Stone, Beth D. Darnall, Anna C. Wilson Source Type: research

Desmetramadol has the Safety and Analgesic Profile of Tramadol Without Its Metabolic Liabilities: Consecutive Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Trials
It has been recommended that the morphine milligram equivalent dose in patients receiving opioid therapy be reduced in order to reduce opioid-related overdose and death.15, 20, 30 There are unfortunately limited pharmacologic options for patients seeking an alternative to schedule II opioids who still require effective analgesia. A critical challenge therefore exists to identify analgesic options for those suffering from pain that are safer and reduce the risk of treatment-related death. (Source: The Journal of Pain)
Source: The Journal of Pain - April 18, 2019 Category: Materials Science Authors: John A. Zebala, Shawn L. Searle, Lynn R. Webster, Matt S. Johnson, Aaron D. Schuler, Dean Y. Maeda, Stuart J. Kahn Source Type: research

Evaluation of post-surgical hyperalgesia and sensitization after open inguinal hernia repair: a useful model for neuropathic pain?
Pre-clinical research has identified numerous mechanisms for neuropathic pain that can be targeted by drugs for pain relief in patients,11 but most novel compounds have failed as clinically useful analgesics.33 These failures emphasize the extent of the difficulties translating drug efficacy from animal models to patients.38 To aid clinical translation, early phase studies may involve testing of potentially analgesic compounds in healthy human volunteers. Such studies involve the induction of symptoms that are relevant to peripheral or central sensitization, against which the potential of an analgesic can be assessed. (Sou...
Source: The Journal of Pain - April 18, 2019 Category: Materials Science Authors: DW Wheeler, A Bhatia, V Mani, S Kinna, A Bell, Y Boyle, BA Chizh, DK Menon, MC Lee Tags: Original Reports Source Type: research

AAPT Diagnostic Criteria for Chronic Painful Temporomandibular Disorders
In order to resolve well-known problems arising from the lack of a comprehensive, reliable, valid and utilitarian taxonomy of common chronic pain conditions, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION) public-private partnership has joined together with the U.S. Food and Drug Administration (FDA) and with the American Pain Society (APS) in order to develop an evidence-based taxonomy applicable to research and clinical management for diagnosing and classifying the most common chronic pain conditions. (Source: The Journal of Pain)
Source: The Journal of Pain - April 18, 2019 Category: Materials Science Authors: Richard Ohrbach, Samuel F Dworkin Tags: Review Article Source Type: research

Regular swimming exercise attenuated neuroma pain in rats: involvement of leptin and adiponectin
Amputation is adopted to save life at the sacrifice of a part of the body in the clinical cases where no existing alternatives could be taken. However, amputation may lead to postamputation pain (PAP) and the pain management is challenging in clinical practice16. Similar to other neuropathic pain conditions, the pathophysiological mechanisms of PAP are complicated and remain to be elucidated, given that multiple levels of nervous system might be involved, ascending from injured peripheral nerve, dorsal root ganglion, to spinal cord dorsal horn and supraspinal regions7,17,31. (Source: The Journal of Pain)
Source: The Journal of Pain - April 12, 2019 Category: Materials Science Authors: Lingling Sun, Yingying Lv, Jinge Tian, Tingting Yu, Fangfang Niu, Xin Zhang, Dongping Du Source Type: research

Remission From Suicidal Ideation Among Those in Chronic Pain: What Factors Are Associated With Resilience?
In North America, suicide is one of the top 10 leading causes of death.10,31 Individuals in chronic pain have a 40% higher risk of lifetime suicidal ideation and attempts than those who do not experience chronic pain.5 Individuals with chronic pain are more likely to develop depression13 and take 8 months longer to remit from depression than those without chronic pain.22 Mental illness is a major risk factor for suicide; an estimated 3 in every 5 of those who die by suicide have an affective disorder, and 91% have some form of mental disorder. (Source: The Journal of Pain)
Source: The Journal of Pain - April 9, 2019 Category: Materials Science Authors: Esme Fuller-Thomson, Lyndsey D. Kotchapaw Tags: Original Reports Source Type: research

Spouse and Patient Beliefs and Perceptions about Chronic Pain: Effects on Couple Interactions and Patient Pain Behavior
Patients ’ beliefs and perceptions about the causes and meaning of their chronic pain have been shown to correlate with pain levels, mood, and various domains of psychosocial functioning.18,20,21,33,35,45 Although the vast majority of this research has focused on the impact of patient beliefs and perceptio ns about chronic pain, the beliefs and perceptions about chronic pain held by family and friends, particularly spouses, may also be related to patient well-being. Couples research by Cano and colleagues11 support this claim. (Source: The Journal of Pain)
Source: The Journal of Pain - April 5, 2019 Category: Materials Science Authors: John W. Burns, Kristina M. Post, David A. Smith, Laura S. Porter, Asokumar Buvanendran, Anne Marie Fras, Francis J. Keefe Tags: Original Reports Source Type: research

Measuring stigma in chronic pain: Preliminary investigation of instrument psychometrics, correlates, and magnitude of change in a prospective cohort attending interdisciplinary treatment
A recent proposal to update the definition of pain states that “[pain] is a distressing experience associated with actual or potential tissue damage with sensory, emotional, cognitive, and social components.”64 This definition highlights the central role of social processes in the pain experience. Consideration of the social context is crucial to understand patients’ adaptation to chronic pain. Supportive social environments, such as those characterized by empathy and validation, may foster well-being among people with chronic pain. (Source: The Journal of Pain)
Source: The Journal of Pain - March 30, 2019 Category: Materials Science Authors: Whitney Scott, Lin Yu, Shrina Patel, Lance M. McCracken Tags: Original Reports Source Type: research

Painful Temporomandibular Disorder is Associated with Migraine in Adolescents: a case-control study
Temporomandibular disorders (TMD) refer to alterations or dysfunctions in the masticatory muscles, the temporomandibular joint (TMJ), and associated structures.49 It has been demonstrated that migraine and painful TMD are comorbid in adults, while tension-type headache (TTH), the most common headache subtype, is not.8,19,21 –23 Migraine, TTH, and TMD are also highly prevalent in adolescents.1,40 (Source: The Journal of Pain)
Source: The Journal of Pain - March 29, 2019 Category: Materials Science Authors: Giovana Fernandes, Marco Ant ônio Arruda, Marcelo Eduardo Bigal, Cinara Maria Camparis, Daniela A.G. Gonçalves Tags: Original Reports Source Type: research

Author Index 2019
Acosta, Frank (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Source Type: research

Neuroimmune Mechanisms of Latent Pain Sensitization after Chemotherapy
The episodic nature of chronic pain has been described in animal models as latent pain sensitization. For example, after remission from inflammatory or postsurgical pain, assessed by normalization of mechanical pain threshold, injection of opioid receptor inverse agonists reinstates allodynia (1,2,3). To investigate whether latent sensitization is also occurring in neuropathic pain and neuroimmune mechanisms are involved, male and female mice were treated with 3 daily injections of cisplatin (2 mg/kg) to induce a transient neuropathic pain. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: G. Laumet, K. Clark, B. Peng, J. Edralin, R. Dantzer, C. Heijnen, A. Kavelaars Source Type: research

Uncovering Cell-Specific Mechanisms in Sex Differences in TLR4-Dependent Pain
Uncovering how different cell types recognize and respond to danger-associated molecular patterns (DAMPs) could lead to new therapeutic insights and a better understanding of basic mechanisms of pain plasticity. Recent studies have bought  to light the necessity to discern sex-specific differences in various pain modalities and different cell-types that mediate these differences. These studies begin to uncover the role of neuroimmune interactions to mediate pain states in a sex-specific fashion. However, direct nociceptor activity a nd intrinsic properties in the context of immune action have not been at the forefront...
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: M. Burton, T. Szabo-Pardi, K. Garner, J. Tierney, T. Price Source Type: research

Social Mechanisms of Psychophysical Pain Disparities
Racial disparities in pain significantly contribute to the public health burden of pain in America and are observable at every level of the pain experience. Racial disparities are even observable in physiological pain response to controlled laboratory stimuli among young healthy populations. However, the mechanisms that underlie this disparity are unknown. Our overarching hypothesis is that disparities in pain sensitivity are due to disparities in social determinants of health that are known to alter central nervous system function. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: V. Mathur Source Type: research

(100) Long-Term Outcomes of Adolescents with Juvenile-Onset Fibromyalgia into Adulthood, and Impact of Depressive Symptoms on Functioning Over Time
The objectives of this study were to describe physical and psychosocial outcomes of youth diagnosed with JFM in early adulthood ( ∼ 8-years after initial assessment), examine longitudinal trajectories of pain and depressive symptoms from adolescence to young adulthood, and examine the impact of pain and depressive symptoms on physical functioning over time. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: W. Black, N. Cunningham, J. Peugh, A. Lynch-Jordan, M. Pfeiffer, T. Ting, S. Kashikar-Zuck Tags: Diagnosis, Assessment, & Reviews (with CE) Source Type: research

(101) Using Quantitative Sensory Testing to Assess the Pain System in Sexual Assault Survivors
Trauma exposure, especially sexual assault (SA), is highly correlated with pain conditions, in that many chronic pain samples report trauma histories. However, our understanding of the mechanisms behind this relationship is limited. Previous findings from our lab suggest that SA disrupts descending pain modulation. However, to date, no study has used quantitative sensory testing (QST) to comprehensively assess the pain system in SA survivors. 41 healthy, pain-free SA survivors were matched to a group of 41 healthy, pain-free trauma exposed persons without SA (TE). (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: N. Hellman, C. Sturycz, E. Lannon, T. Toledo, B. Kuhn, Y. G üereca, B. Hahn, M. Payne, F. Huber, M. Demuth, S. Palit, J. Shadlow, J. Rhudy Source Type: research

(102) Child Anxiety Mediates the Relationship between Parent Anxiety and Child Somatization in Youth with Functional Abdominal Pain
Functional abdominal pain disorders (FAPD) are common pediatric pain conditions that often present with co-occurring anxiety, which is associated with adverse outcomes including increased pain, disability, and somatization. Parents of children with abdominal pain report higher levels of anxiety than parents of children without abdominal pain disorders. In addition, measures of child anxiety (e.g., anxiety sensitivity) in youth with pain conditions are related to somatization and other adverse outcome. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: S. Love, A. Kalomiris, C. Le, N. Cunningham Source Type: research

(103) The Impact of Self-Reported Sleep Disturbances on Preoperative Experimental Pain Sensitivity and Knee Arthroplasty Outcomes
Approximately 18% of patients undergoing lower extremity joint arthroplasty fail to significantly improve following arthroplasty. We previously demonstrated that higher levels of fibromyalgia (FM) symptoms ( “FMness”) prior to surgery are associated with less postoperative improvement. Sleep disturbances, which are a core symptom domain in FM, are present in greater than 90% of chronic pain patients. Here, we consider the impact of self-reported sleep disturbances on knee arthroplasty outcomes six m onths after surgery (n=74, 54% female), and on psychophysical pain sensitivity in a subset of these patients preo...
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: T. Bellomo, S. Harte, A. Schrepf, C. Brummett, D. Clauw Source Type: research

(104) The Aging Lumbosacral Spine and Development of Chronic Lower Back Pain
Chronic lower back pain continues to be a leading cause of disability, loss of work, and medical expenditures in the United States. As our baby-boom generation continues to age, medical healthcare will become increasingly tailored to providing care for the elderly. The World Health Organization speculates the geriatric population will reach two billion by 2050.1 This is a literature review describing the anatomic changes in the lumbosacral spine angle that occur with aging possibly contributing to chronic lower back pain. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: M. Patel Source Type: research

(105) The Effect of Acute and Chronic Pain on the Accuracy of Temporal Perception
Pain has been shown to interfere with executive functions that require a high cognitive load, including attentional processes. According to Scalar Expectancy Theory, perception of time can be influenced by the same attentional processes that are impacted by pain. The present, ongoing study aims to extend previous work by examining the effects of both acute experimental and chronic pain on temporal perception. We hypothesized that (1) both acute and chronic pain would result in less accurate and more variable temporal perception, (2) both acute and chronic pain would increase the perceived duration of timed event, and that ...
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: S. Meints, A. Warren, R. Edwards, D. Moore Source Type: research

(106) Pain Intensity as a Lagging Indicator of Patient Improvement: Longitudinal Relationships with Sleep, Mood, and Function in Multidisciplinary Care
Patients and many providers assume that chronic pain intensity must be reduced before improvements in other patient reported outcomes such as mood and function are possible. However, there has been relatively little empirical inquiry into the temporal ordering of improvements in chronic pain treatment. It is unclear whether improvements in other domains are likely to emerge earlier in multidisciplinary care or their consequent implications for pain relief. The current study sought to examine these questions in patients presenting for chronic pain specialty care using data from PainTracker, a patient-reported outcome-tracki...
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: J. Sturgeon, D. Langford, D. Tauben, M. Sullivan Source Type: research

(107) Comparing Apples to an Orange: Legacy Measures versus PROMIS for Assessing Anxiety in Youth with Chronic Pain
Patient-Reported Outcomes Measurement Information System (PROMIS) measures are reliable, brief instruments to measure patient health. The PROMIS pediatric anxiety short form assesses anxiety symptoms; however, its ability to capture a clinically meaningful understanding of anxiety is unknown. Within pediatric chronic pain, anxiety is generally assessed by legacy measures examining anxiety symptoms specific to pain [e.g., Pain Catastrophizing Scale for Children, (PCS-C)] or broadly [The Screen for Child Related Anxiety Disorders, (SCARED)], which have been shown to predict pain-related outcomes. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: A. Lynch-Jordan, N. Cunningham, A. Szabova, K. Goldschneider Source Type: research

(108) Bilateral Sensory Deficits and Widespread Hyperalgesia following Delayed Onset Muscle Soreness of the Quadriceps
Unaccustomed eccentric exercise leads to delayed onset muscle soreness (DOMS). While DOMS has been demonstrated to result in altered postural control which may result in further injury, very little is known about the somatosensory changes at the knee in presence of DOMS of the quadriceps. DOMS elicited in this muscle was hypothesized to result in bilateral induced mechanical hyperalgesia, measured via pressure pain threshold (PPT) and hypoesthesia, evidenced by deficits in both vibration perception threshold (VPT) and proprioception which was measured via threshold to detection of passive motion (TDPM). (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: C. Courtney Source Type: research

(109) Aging Back Clinics – A Geriatric Syndrome Approach to Treating Low Back Pain in Older Adults: Results of a Preliminary Randomized Controlled Trial
Treating chronic low back pain (CLBP) with spine-focused interventions is common, potentially dangerous, and often ineffective. We posit that CLBP in older adults is a geriatric syndrome – a final common pathway for the expression of multiple contributors. We have published evidence and expert consensus-based algorithms to guide evaluation and treatment of key biopsychosocial CLBP contributors in older adults – hip osteoarthritis, myofascial pain, fibromyalgia, sacroiliac joint syndrome, lumbar spinal stenosis, leg length inequality, lateral hip/thigh pain, anxiety, depression, insomnia, and maladaptive coping....
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: D. Weiner, A. Gentili, M. Rossi, K. Coffey-Vega, K. Rodriguez, K. Hruska, L. Hausmann, S. Perera Source Type: research

(110) Impact of Pain Severity among Patients with Osteoarthritis on Healthcare Use in the United States
Osteoarthritis (OA) is the leading cause of disability in older adults. Total healthcare costs tend to rise as pain severity associated with OA increases. To understand treatment and healthcare resource utilization (HCRU) by OA pain severity, data were collected from Feb-May 2017 using US Adelphi Disease Specific Programme, a cross-sectional survey of primary care physicians, rheumatologists, orthopedists and their patients. Descriptive statistics were used and all data were analysed using SPSS v6 and Stata v14.1. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: R. Robinson, J. Bobula, J. Cappelleri, A. Bushmakin, L. Tive, L. Viktrup, J. Mellor, N. Williams, P. Hubanova, J. Jackson Source Type: research

(111) Trends in Diagnostic Coding for Musculoskeletal Conditions: An Evaluation of ICD-10 Use in the Veterans Health Administration
In this study, we examined the most frequently utilized MSD-related ICD-10 diagnostic codes and describe their association with Veteran characteristics. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: B. Coleman, J. Goulet, D. Higgins, T. Kawecki, H. Bathulapalli, A. Heapy Source Type: research

(112) Childhood Adversity Linked to Heightened Pain Sensitivity in Adults
Childhood experiences of adverse social conditions have demonstrated lifelong downstream health-related consequences. Since more exposure to adverse childhood events (ACEs) are associated with poorer outcomes, their exposure can be considered a social determinant of health and wellness. The mechanism of ACEs contributing to adverse health consequences may lie in chronic activation of the stress pathway, leading to dysregulation of the neuroendocrine, immune, and autonomic systems. Chronic stress, experienced in childhood, appears to change the physiologic response to subsequent stress, perhaps though HPA and immune axes. (...
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: R. Sheinberg, C. Campbell, A. Kearson, E. Burton, J. Letzen Source Type: research

(113) Sleep Deficiency and Disability in Adolescents with Chronic Abdominal Pain
This study sought to characterize the etiology of sleep deficiency in adolescents with CAP and examine the associations between sleep and functioning. The sample included 21 adolescents 14 to 18 years old with CAP (female=85.7%, mean age=16.5 years). CAP is defined by abdominal pain present for two or more months, experienced at least four times per month, and not explained by another condition. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: S. Tham, L. Daley, T. Palermo Source Type: research

(114) The Electronic Patient Visit Assessment (ePVA): Using Interactive Technology to Detect Pain and Functional Limitations in Head and Neck Cancer
Patients with head and neck cancer can experience pain that impacts quality of life. Therefore, we developed a patient-reported Electronic Patient Visit Assessment (ePVA) for early detection and intervention for pain. Patients use interactive touch screen technology to indicate presence and location of pain and functional limitations (eg. limited mobility of mouth, neck, shoulders). To test clinical usefulness of the ePVA, after informed consent, 72 participants with head and neck cancer completed the ePVA one time before, during, or after treatment at an academic cancer center in northeastern United States between August ...
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: J. Van Cleave, M. Fu, B. Egleston, M. Persky Source Type: research

(115) Interleukin-6 is Associated with Abdominal Muscle Growth in Knee Osteoarthritis Patients
Interleukin-6 (IL-6) is a cytokine with various functions ranging from regulating inflammatory pathways to immune system responses. Pro-inflammatory cytokines are associated with excess inflammation which has been implicated as a mechanism in the transition from acute to chronic pain. However, through the classic signaling pathway, IL-6 can also act as an anti-inflammatory myokine, an indication of muscle growth and myogenesis. However, its association with body composition and how they are associated with pain following surgery are not well defined. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: H. Nguyen, V. Prasath, C. Campbell Source Type: research

(116) Pain Assessment in the Pediatric Intensive Care Unit: FLACC in Action
Pain assessment in the pediatric intensive care unit (PICU) is complex, as the patient population is diverse in age, cognitive development, and acuity. Appropriate use of pain assessment instruments is vital for clinicians to identify patients experiencing pain and to evaluate the effectiveness of interventions provided. The Face, Legs, Activity, Cry, and Consolability (FLACC) pain scale is commonly used in North American PICUs to assess pain in patients who are unable to provide self-report.  However, clinical application of the FLACC has not been studied in this setting. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: N. Pierce, C. LaFond Source Type: research

(117) Characterizing Fibrofog in Daily Life: Ambulatory Cognitive Functioning in Adults with Fibromyalgia and Matched Controls
Most people with fibromyalgia (FM) report “fibrofog”, or cognitive dysfunction. To better characterize fibrofog in daily life, we conducted an ambulatory study of subjective and objective cognitive function in real-world settings in persons with FM and sex-, age-, and education-matched healthy controls (HC) to test whether: 1) people wi th FM demonstrate poorer cognitive function on ambulatory measures; 2) people with FM demonstrate a different diurnal pattern of cognitive function; and 3) subjective cognitive function corresponds more highly with objective cognitive measures in HC compared to FM. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: A. Kratz, D. Williams, D. Clauw, D. Whibley, M. Sliwinski Tags: Disease Entities (Human) (with CE) Source Type: research

(118) Cancer and Opioids: Patient Experiences with Stigma (COPES) – A Pilot Study
Unrelieved cancer pain is common, with up to 57% of patients receiving curative-intent treatment reporting moderate-to-severe pain. Opioids are a cornerstone in cancer pain management, but the “opioid crisis” has sparked public fears about risks associated with these medications. Though cancer patients are excluded from most laws restricting prescription opioids, patients may still internalize stigma associated with opioid use. Thus, the aim of this pilot study was to 1) describe opio id use and 2) characterize opioid-related stigma and associated behaviors in cancer patients. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: H. Bulls, A. Hoogland, D. Craig, B. Gonzalez, D. Portman, H. Jim Source Type: research

(119) The Role of Environmental Distractions in the Experience of Fibrofog in Real-World Settings
Cognitive problems in fibromyalgia (FM), or “fibrofog,” are highly prevalent but not well-characterized. Research shows that deficits in cognitive performance in FM only emerge in the context of a stimulating testing environment, suggesting a potentially important role for distraction in the experience of both subjective (perceived) and o bjective (performed) fibrofog. Unexplored to date is the role of real-world distractions in fibrofog in everyday life. To address limitations in our understanding of fibrofog in daily life, we conducted a study of ambulatory subjective and objective cognitive function in a sam...
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: A. Kratz, D. Williams, D. Clauw, D. Whibley, M. Sliwinski Source Type: research

(120) Opioid Prescription Claims among Medicaid Enrolled Children and Young Adults with Sickle Cell Disease in North Carolina
We examined Medicaid claims for 2,850 enrollees (March 2016 – February 2017) with SCD in NC. The sample included 0 to 22 year olds (n= 1,560), Pre-School [0-5 years], n=428; School Age [6-10 years], n=366; Middle School [11-14 years], n=261; Adolescent [15-18 years], n=284; and Young Adult [19-22 years], n=221). (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: N. Crego, C. Douglas, N. Shah, M. Knisely, E. Bonnabeua, M. Earls, K. Eason, E. Merwin, P. Tanabe Source Type: research

(121) Pain, Sleep Disturbances, Fatigue, Mood Changes, and Underlying Inflammation: A Study of Patients with Chronic Low Back Pain (CLBP)
CLBP is a highly prevalent (55% adults) and expensive (costs range $84-$624.8 billion) condition in the United States. CLBP is accompanied by distressing behavioral symptoms, such as depressed mood, fatigue, and sleep disturbance, which negatively impact quality of life (QOL). The purpose of the study was to determine the extent to which behavioral symptoms (depressive mood, fatigue, poor sleep), independently or as a cluster, predict pain severity and QOL. Proinflammatory cytokine (IL-6) was evaluated to determine the extent to which inflammation may serve as a common underlying mechanism. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: A. Saravanan, D. Tell, H. Mathews, P. Bajaj, L. Witek Janusek Source Type: research

(122) S100B Single Nucleotide Polymorphisms and Haplotypes Associate with Both  Acute Crisis Pain and Chronic Pain in Sickle Cell Disease
In this study, we examine the influence of single nucleotide polymorphisms (SNP) in the S100B gene on acute and chronic pain variation in SCD. 136 subjects with SCD recorded their baseline, non-crisis pain experience on a digital version of the McGill Pain Questionnaire, from which we obtained composite pain index (CPI) scores as a measurement for chronic pain. Utilization of emergency or urgent care owing to painful crisis was recorded as a marker for acute pain. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: N. Sadhu, E. Jhun, Y. Yao, Y. He, D. Wilkie, R. Molokie, Z. Wang Source Type: research

(123) Visceral Pain Mechanisms: Features of Constant Pain and Genetic Linkage in Chronic Pancreatitis Patients
Abdominal pain is the most distressing feature of chronic pancreatitis (CP) and drives health care utilization. Compared to intermittent pain, constant CP pain is associated with significantly lower physical and mental quality of life scores. However, the characteristics of constant pancreatic pain appears to be different from constant somatic pain, and pain classification correlates poorly with environmental and metabolic factors. Our Aim was to determine whether genetic factors contribute to severe and/or constant pain in patients with CP. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: D. Whitcomb, J. Saloman, A. Phillips, P. Greer, C. Shelton, G. Papachristou, D. Yadav, K. Albers, B. Davis Source Type: research

(124) Perceived Injustice Mediates the Relationship between Chronic Pain Stigma and Chronic Low Back Pain (CLBP) Severity
Chronic low back pain (CLBP) is among the most pervasive, painful conditions in the United States. For most patients with CLBP, the cause is “non-specific” – meaning, there is no clear association between pain and identifiable pathology of the spine or associated tissues. Research has shown that laypersons and providers alike are less inclined to help, feel less sympathy, dislike patients more, suspect deception, and attribute lowe r pain severity to patients whose pain does not have an objective basis in tissue pathology. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: T. Penn, D. Overstreet, Z. Trost, B. Goodin Source Type: research

(125) When Patients Take Charge of Opioids: Self-Management and Safety of Prescribed Opioids for Cancer Pain in the Context of Opioid Crisis
Among insured adults, patients with cancer have more pharmacy claims and claims for higher doses of opioids. Patients with cancer also remain exempt from most state legislation and policy initiatives on prescribing opioids, necessitating a critical understanding of opioid management and risks among this group. This multi-method study investigated pain and opioid self-management practices reported by adult cancer patients recruited from an outpatient oncology clinic of an NCI-designated cancer center (n=65; mean age 56.3, SD=12.3; pain 6.0, SD=2.8;>50% with metastatic disease; IRB approval, University of Pennsylvania). (...
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: S. Meghani, J. Davis, N. Vapiwala, F. Barg Source Type: research

(126) Development of a Longitudinal Pain and Opioid Curriculum
The Mayo Clinic School of Medicine has identified pain management and opioid/substance abuse as a top five common societal problem that needs to be taught and addressed within the undergraduate medical curriculum. A Pain Curriculum Sub-committee was formed to 1) gather content experts together to collaborate and provide expertise, 2) examine the current state of pain management curriculum, and 3) create a plan for enhancing pain curriculum throughout the four years of medical school. The sub-committee created a curriculum map to identify the current pain curriculum (e.g., course objectives, sessions, session level objectiv...
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: J. Sperry, A. Seegmiller Renner Source Type: research

(127) ACGME Required 40 Peripheral Nerve Blocks in Anesthesia Education: Is it Enough?
Residents with at least 40 completed peripheral nerve blocks were given an ongoing set of blocks to perform and were evaluated by their supervising attending using an objective scale. Each resident was tasked an ultrasound guided block they have familiar experience with. A scoring scale of 1-10 was used with certain important tasks having point values attributed. A resident was given 1 point for proper completion of pre-block protocol. This includes performing a patient verification time-out indicating the correct patient, site, surgery and block to be performed. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: D. King Source Type: research

(128) Haplotype Analysis of COMT SNPs Associated with Pain Intensity and Acute Care Utilization in Adults with Sickle Cell Disease
Several COMT gene single nucleotide polymorphisms (SNPs) have been associated with pain and disability indicators in pain populations. Only one COMT SNP (rs4680) has been studied in patients with sickle cell disease (SCD) and found to be associated with pain-related acute care utilization but not with self-reported pain. Our aim was to examine the association among haplotypes of 14 other COMT SNPs with pain intensity and pain-related acute care utilization in SCD. Genetic and clinical data were collected on 130 (66% female, mean age 35.0+11.4 years, 76.2% Hemoglobin SS disease) individuals with SCD. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: K. Roach, Y. Yao, S. Chamala, V. Black, H. Ahn, R. Fillingim, M. Ezenwa, J. Schlaeger, M. Suarez, R. Molokie, Z. Wang, D. Wilkie Tags: Molecular and Cellular Biology (with CE) Source Type: research

(129) Sleep Changes in Adolescents with Chronic Pain Enrolled in Intensive Interdisciplinary Pain Treatment
Research demonstrates bi-directional associations between sleep difficulty and chronic pain, as well as relationships between sleep, daily function, and mental health. Adolescents with chronic pain frequently report difficulty falling and staying asleep, associated daytime fatigue, and decreased energy levels. However, few studies track both objective and subjective sleep changes in adolescents with chronic pain, and how these changes impact measures of daily functioning and mental health. This prospective longitudinal study followed 62 adolescents (53 female, age 13-17) through an intensive interdisciplinary pain treatmen...
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: J. Perera, D. Wallace, T. Maag, C. Hoffart Tags: Systems (Physiology, Anatomy, Animal Models) (with CE) Source Type: research

(130) Does Sedentary Time Impact Pain and Flexibility in College Students?
This study aims to quantify the effects of sedentary activity on pain and lumbar and hip flexibility of college students. Healthy students (18-26 years) were recruited for 1 research session. Pre-Sedentary measurements including self-reported pain (Visual Analog Scale [VAS], flexion (F)& extension (E) LROM [Modified-Modified Schober Test, MMST] and hip ROM for extension [EXT], internal rotation [IR], and external rotation [ER]) were measured. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: S. Stolzman, C. Henry, S. Imrie, L. Sulikowski, K. Thoren Source Type: research

(131) Impact of an Interactive Music App on Pain Threshold, Temporal Summation, and Conditioned Pain Modulation in Healthy Volunteers
Music has been shown to decrease pain and modulate affect, but the mechanism by which music conveys analgesia in relatively unexplored . Using quantitative sensory testing (QST), we assessed the impact of a novel app-based music intervention on the nociceptive processing of pain. Healthy volunteers (n=60) were assessed for psychosocial traits including anxiety, depression, and catastrophizing using validated questionnaires. QST included investigation of: 1) pain sensitivity as measured by pressure pain threshold and tolerance using a handheld algometer, as well as reported pain to weighted pinprick stimuli, 2) temporal sum...
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: J. Gale, P. Chai, G. Jambaulikar, M. Patton, E. Schwartz, E. Boyer, R. Edwards, K. Schreiber Tags: Treatment Approaches (Complementary & Alternative) (with CE) Source Type: research

(132) Predictors of Opioid Analgesic Prescription in Adult Outpatients with Sickle Cell Disease
Opioid analgesics are the mainstay therapy for managing severe pain of sickle cell disease (SCD) for the 100,000 Americans afflicted with it. However, there is limited evidence on the contribution of sociodemographic and clinical factors as predictors of opioid prescription in adult outpatients with SCD. Using baseline data from an ongoing longitudinal clinical trial, the purpose of this descriptive, cross-sectional study was to determine sociodemographic and clinical factors that predict opioid prescription calculated as Morphine Sulfate Equivalent (MSEQ) in adult outpatients with SCD. (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: M. Ezenwa, J. Schlaeger, Y. Yao, R. Molokie, Z. Wang, M. Suarez, V. Angulo, D. Shuey, K. Roach, D. Wilkie Tags: Treatment Approaches (Medical/Interventional) (with CE) Source Type: research

(133) Preliminary Analysis of the Relationship between Refractory Menstrual Pain and Naproxen Metabolism
Non-steroidal anti-inflammatory drugs are commonly used to treat painful periods, also known as dysmenorrhea. A subset of women, however, do not benefit from this treatment. Since the pharmacological basis of treatment resistance in dysmenorrhea has not been characterized, we assessed the relationship between measures of naproxen metabolism and self-reported menstrual pain relief. While on their menses, dysmenorrheic participants (n=24) and healthy controls (n=11) answered questionnaires assessing their menstrual pain, including a 0-100 visual analog scale (VAS). (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: K. Hellman, F. Oladosu, F. Tu Source Type: research

(134) Spinal Cord Stimulator (SCS) Therapy among Active Duty Military Members Decreased Opioid Therapy and Improves Overall Pain
The objective of this quality improvement project was to determine if SCS implantation improves outcomes for ADMM. This project compared a sub-sample of the Walter Reed National Military Medical Center (WRNMMC) SCS Cohort: patients who were ADMM at the time of implantation and for those whom we had data at 3-months and 6-months following implantation (N=89). (Source: The Journal of Pain)
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: E. Park, L. Wandner, C. Kurihara, S. Lindeire, R. Liu, M. Jacobs, S. Griffith Source Type: research