Experimental Pain Decreases Corticomuscular Coherence in a Force- But Not a Position-Control Task
Neural drive to muscles is altered in pain, but this depends on task type. Acute experimental pain reduces the discharge rate of many active motor units during gentle isometric contractions,12,51,54 but this is less pronounced in position- than force-control tasks.44 Even when tasks are identical in mechanical requirements and muscle torques, neuromotor control during position- and force-control tasks differs. Task-specific differences at the spinal cord and descending inputs are thought to explain this difference. (Source: The Journal of Pain)
Source: The Journal of Pain - November 15, 2018 Category: Materials Science Authors: Peter C. Poortvliet, Kylie J. Tucker, Simon Finnigan, Dion Scott, Paul W. Hodges Tags: Original Reports Source Type: research

Cannabinoid type 2 (CB2) receptor system modulates paclitaxel-induced microglial dysregulation and central sensitization in rats
Chemotherapy-induced peripheral neuropathy (CIPN) occurs in 40 to 60% of patients who receive paclitaxel, which is used clinically to treat breast, lung, and ovarian cancer.12,44 CIPN appears to be a dose-limiting toxicity, especially after multiple treatment courses.49 CIPN may also persist for years after the therapy is stopped; a small percentage of patients experience life-long CIPN.15 (Source: The Journal of Pain)
Source: The Journal of Pain - November 8, 2018 Category: Materials Science Authors: Jiang Wu, Mark Hocevar, Bihua Bie, Joseph F Foss, Mohamed Naguib Source Type: research

SIGMA-1 Receptor Gene Variants Affect the Somatosensory Phenotype in Neuropathic Pain Patients
Neuropathic pain arises as a direct consequence after lesion or disease affecting the somatosensory system.35 Typically it is characterized by positive symptoms such as ongoing or evoked pain as well as negative symptoms like reduced sensitivity in the affected skin area and adjacent areas.2,26 Globally, 0.9% to 17.9% of adults are suffering from chronic pain with neuropathic features.8,16,36 However, there is only a limited number of drugs with proven efficacy in treatment of neuropathic pain often also causing considerable adverse side effects. (Source: The Journal of Pain)
Source: The Journal of Pain - November 1, 2018 Category: Materials Science Authors: Juliane Sachau, Henrike Bruckmueller, Janne Gierthm ühlen, Walter Magerl, Meike Kaehler, Sierk Haenisch, Andreas Binder, Amke Caliebe, Christoph Maier, Rolf-Detlef Treede, Thomas Tölle, Ingolf Cascorbi, Ralf Baron Tags: Original Reports Source Type: research

Was that painful or non-painful? The Sensation and Pain Rating Scale (SPARS) performs well in the experimental context
Pain intensity is best assessed by self-report. Clinicians and researchers attempt to capture another's pain using cross-modality matching tasks in which pain is matched to a rating scale.31 Numerical rating scales (NRS) and visual analogue scales (VAS) anchored at opposite extremes with ‘no pain’ and something akin to ‘most intense pain you can imagine’ are widely used, and have evidence for being robust assessments of pain in clinical and experimental contexts.8 Indeed, for both of these scale types, the stimulus-response relationship has been described by a classical psyc hophysical power relatio...
Source: The Journal of Pain - November 1, 2018 Category: Materials Science Authors: Victoria J Madden, Peter Kamerman, Valeria Bellan, Mark J Catley, Leslie N Russek, Danny Camfferman, G Lorimer Moseley Tags: Original Reports Source Type: research

Masthead
(Source: The Journal of Pain)
Source: The Journal of Pain - October 31, 2018 Category: Materials Science Source Type: research

Editorial Board
(Source: The Journal of Pain)
Source: The Journal of Pain - October 31, 2018 Category: Materials Science Source Type: research

Table of Contents
(Source: The Journal of Pain)
Source: The Journal of Pain - October 31, 2018 Category: Materials Science Source Type: research

Endogenous pain modulation profiles among individuals with chronic pain: Relation to opioid use
It is well known that nociceptive signals can be modulated by central pain inhibitory and facilitatory processes 1,8,82. These pain-modulatory processes operate at various levels of the central nervous system and are assumed to play a determining role in the manifestations of chronic pain and in shaping inter-individual variability in the trajectory of many persistent pain conditions 6,25,51,83. Considerable studies have been conducted using quantitative sensory testing (QST) to assess pain inhibition and pain facilitation 9,19,71. (Source: The Journal of Pain)
Source: The Journal of Pain - October 29, 2018 Category: Materials Science Authors: Marc O. Martel, Kristian Petersen, Marise Cornelius, Lars Arendt-Nielsen, Robert Edwards Tags: Original Reports Source Type: research

Greater response interference to pain faces under low perceptual load conditions in adolescents with impairing pain: A role for poor attention control mechanisms in pain disability?
Chronic pain is common in young people.16 Some adolescents with pain experience significant interruptions to functioning.9,19,28 Yet, there are few interventions that effectively reduce pain-linked disability.8 Better understanding of factors influencing disability within adolescent chronic pain could inform treatment innovation.7 Information-processing accounts of chronic pain, which attribute fear and avoidance and disability to biases in early threat classification could provide this understanding. (Source: The Journal of Pain)
Source: The Journal of Pain - October 29, 2018 Category: Materials Science Authors: Jennifer Y.F. Lau, Eva Sprecher, Sara Haas, Stephen Lisk, David Pagliaccio, Louise Sharpe, Yair Bar-Haim, Daniel S. Pine Tags: Original Reports Source Type: research

Fulranumab as Adjunctive Therapy for Cancer-Related Pain: A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study
Pain resulting directly or indirectly from the growth of malignant cells is one of the most common and distressing symptoms associated with cancer.62 Cancer-related pain occurs in approximately one-quarter of the patients at the time of diagnosis and early in the course of disease, in three-quarters of the patients with advanced disease, and in almost one-third of the patients on active therapy.10,15,62 It is estimated that almost one in two patients with cancer pain are sub-optimally treated.10 (Source: The Journal of Pain)
Source: The Journal of Pain - October 24, 2018 Category: Materials Science Authors: Neal Slatkin, Naim Zaki, Steven Wang, John Louie, Panna Sanga, Kathleen M. Kelly, John Thipphawong Source Type: research

Pharmacological modulation of endogenous opioid activity to attenuate neuropathic pain in rats
Endomorphins (EMs) are widely considered to be the endogenous ligands for the mu-opioid receptor (MOR), the predominant opioid receptor mediating antinociception. Central administration of EM1 (Tyr-Pro-Trp-Phe-NH2) and EM2 (Tyr-Pro-Phe-Phe-NH2) produce potent MOR-mediated antinociception.57,60,70 We previously reported that the magnitude of antinociception elicited by the spinal application of EM2, varies across the rat estrous cycle, minimal during diestrus but robust, comparable to that of male rats, during proestrus. (Source: The Journal of Pain)
Source: The Journal of Pain - October 23, 2018 Category: Materials Science Authors: Nai-Jiang Liu, Emiliya M. Storman, Alan R. Gintzler Source Type: research

Imagining My Painful Hand Is Not Mine: Self-distancing Relieves Experimental Acute Pain Induced by a Cold Pressor Task
Pain, whether emotional or physical, has broad adverse effects on well-being. Over the past decades, various psychological interventions, such as cognitive-behavioral therapy (CBT) and acceptance and commitment therapy (ACT), that focus on changing either cognitive content or cognitive processes have been developed to cope with pain. ACT is regarded as a ‘‘third-wave’’ cognitive-behavioral therapy to cope with pain and is distinguished by its primary focus on psychological flexibility (PF). PF is defined as the capacity to be directly, consciously, and fully in contact with the present moment withou...
Source: The Journal of Pain - October 16, 2018 Category: Materials Science Authors: Tong Wang, Lian Lian Yang, Zhou Yang, Xi Ting Huang Tags: Original Reports Source Type: research

Operant learning versus energy conservation activity pacing treatments in a sample of patients with fibromyalgia syndrome: A pilot randomized controlled trial
Fibromyalgia syndrome (FMS) is a clinical condition characterized by chronic widespread pain, fatigue, and non-refreshing sleep, and is frequently associated with cognitive impairment 13. FMS prevalence in the general adult population ranges between 2% and 6% 13. Exercise and cognitive behavioral therapy (CBT) are strongly recommended, in addition to pharmacologic therapy, as essential parts of its treatment 3,13. However, one of the challenges in assessing the effectiveness of CBT is that it involves various interventions 53. (Source: The Journal of Pain)
Source: The Journal of Pain - October 13, 2018 Category: Materials Science Authors: M élanie Racine, Mark P. Jensen, Manfred Harth, Patricia Morley-Forster, Warren R. Nielson Source Type: research

Generalization and Extinction of Concept-BasedPain-Related Fear
In chronic pain, pain-related fear seems to overgeneralize to safe stimuli, thus contributing to excessive fear and avoidance behavior. Evidence shows that pain-related fear can be acquired and generalized based on conceptual knowledge. Using a fear conditioning paradigm, we investigated whether this concept-based pain-related fear could also be extinguished. During acquisition, exemplars of 1 action category (conditioned stimuli [CSs]; eg, opening boxes) were followed by pain (CS+), whereas exemplars of another action category were not (CS –; eg, closing boxes). (Source: The Journal of Pain)
Source: The Journal of Pain - October 5, 2018 Category: Materials Science Authors: Eveliina Glogan, Christine van Vliet, Rani Roelandt, Ann Meulders Tags: Original Reports Source Type: research

Generalization and extinction of concept-based pain-related fear
Fear can be acquired through associative learning. The ability to learn that certain stimuli predict aversive outcomes facilitates the employment of appropriate defensive responses. Since threat can present itself in many forms, generalizing a once-learned stimulus-outcome association beyond a specific instance benefits survival. Fear generalization is the adaptive ability to extrapolate information from an aversive learning experience and apply it to novel, similar threatening encounters.18,21,25,26 However, when these defensive responses spread to safe stimuli, fear and avoidance may become maladaptive. (Source: The Journal of Pain)
Source: The Journal of Pain - October 5, 2018 Category: Materials Science Authors: Eveliina Glogan, Christine van Vliet, Rani Roelandt, Ann Meulders Tags: Original Reports Source Type: research

Does sensorimotor incongruence trigger pain and sensory disturbances in people with chronic low back pain? A randomised cross-over experiment
Chronic low back pain (CLBP) is a common, complex and hard to treat disorder [20; 21; 40; 42]. The global point prevalence of low back pain (LBP) was estimated at 9.4% in 2010, with the highest prevalence of 15% in Western Europe [21]. When pain persists and becomes chronic, it has a vast socioeconomic impact [42]. Overall, unravelling the underlying mechanisms of CLBP is important to improve the effectiveness of care. (Source: The Journal of Pain)
Source: The Journal of Pain - October 5, 2018 Category: Materials Science Authors: Sanneke Don, Maarten Venema, Margot De Kooning, Bart van Buchem, Jo Nijs, Lennard Voogt Source Type: research

Deep tissue incision enhances spinal dorsal horn neuron activity during static isometric muscle contraction in rats
Severe acute postoperative pain often complicates the recovery process after surgery,15,27 resulting in prolonged hospitalization associated with respiratory and cardiovascular complications.5,8,15,33 (Source: The Journal of Pain)
Source: The Journal of Pain - October 5, 2018 Category: Materials Science Authors: He Gu, Daisuke Sugiyama, Sinyoung Kang, Timothy J. Brennan Tags: Original Reports Source Type: research

Characteristics Associated With High-Impact Pain in People With Temporomandibular Disorder: A Cross-Sectional Study
Temporomandibular disorder (TMD) is a public health problem. It is characterized by pain in the jaw joint, face, and masticatory muscles and can become chronic. Although the hallmarks of TMD, as a regional pain disorder, are pain in the temporomandibular joints and masticatory muscles, people with TMD often experience pain in many other areas of the body.44 (Source: The Journal of Pain)
Source: The Journal of Pain - October 4, 2018 Category: Materials Science Authors: Vanessa E. Miller, Charles Poole, Yvonne Golightly, Deborah Barrett, Ding-Geng Chen, Richard Ohrbach, Joel D. Greenspan, Roger B. Fillingim, Gary D. Slade Tags: Original Reports Source Type: research

Characteristics associated with high-impact pain in people with TMD: a cross-sectional study
Temporomandibular disorder (TMD) is characterized by pain in the jaw joint, face, and masticatory muscles that can become chronic. Although the hallmarks of TMD, as a regional pain disorder, are pain in the temporomandibular joints and masticatory muscles, people with TMD often experience pain in many other areas of the body.44 (Source: The Journal of Pain)
Source: The Journal of Pain - October 4, 2018 Category: Materials Science Authors: Vanessa E. Miller, Charles Poole, Yvonne Golightly, Deborah Barrett, Ding-Geng Chen, Richard Ohrbach, Joel D. Greenspan, Roger B. Fillingim, Gary D. Slade Tags: Original Reports Source Type: research

The Effects of Partners ’ Helping Motivation on Chronic Pain Patients’ Functioning over Time
Because partners of individuals with chronic pain (ICP) may differ considerably in their helping responses (e.g., providing emotional, instrumental and informational support4), various attempts have been undertaken to categorize helping responses of close others in terms of its expected implications for ICP's functioning (e.g.,9). To fully understand whether partners ’ helping response is truly helpful and promotes ICP's adjustment, the present research draws on Self-Determination Theory (SDT,7,34), a broad theory on human motivation. (Source: The Journal of Pain)
Source: The Journal of Pain - October 4, 2018 Category: Materials Science Authors: Sara Kindt, Maarten Vansteenkiste, Katrijn Brenning, Liesbet Goubert Source Type: research

Waiting for a pediatric chronic pain clinic evaluation: A prospective study characterizing waiting times and symptom trajectories
Epidemiological studies indicate that chronic pain is common in children and adolescents with median prevalence rates of 11% to 38% depending upon the condition.14 Chronic pain negatively affects multiple domains of functioning for children and adolescents including school attendance, social, physical, and athletic activities, and emotional functioning.16 Because longitudinal data demonstrates that childhood chronic pain places individuals at significant risk for developing or continuing with chronic pain, physical symptoms, and psychiatric complaints into adulthood,22 effective treatment of pain in childhood is critical f...
Source: The Journal of Pain - October 4, 2018 Category: Materials Science Authors: Tonya M. Palermo, Margaret Slack, Chuan Zhou, Rachel Aaron, Emma Fisher, Sade Rodriguez Tags: Original Reports Source Type: research

Masthead
(Source: The Journal of Pain)
Source: The Journal of Pain - October 1, 2018 Category: Materials Science Source Type: research

Editorial Board
(Source: The Journal of Pain)
Source: The Journal of Pain - October 1, 2018 Category: Materials Science Source Type: research

Table of Contents
(Source: The Journal of Pain)
Source: The Journal of Pain - October 1, 2018 Category: Materials Science Source Type: research

The Non-Avoidant Pacing Scale: Development and preliminary validation
Activity pacing has emerged as a common treatment component aimed at improving functioning in patients with chronic pain5,7,35,38,47,48, however, few studies have examined the relationship between pacing and key outcomes. A meta-analysis revealed a correlation between more pacing and reduced depression, but also higher levels of pain and disability1. It appears counterintuitive that pacing, a strategy taught to patients with chronic pain, would be associated with poorer outcomes. However, there is a lack of clarity surrounding the concept itself. (Source: The Journal of Pain)
Source: The Journal of Pain - September 29, 2018 Category: Materials Science Authors: Renata Hadzic, Louise Sharpe, Bradley Wood, Carolyn MacCann Tags: Original Reports Source Type: research

Self-medication with over-the-counter analgesics: a survey of patient characteristics and concerns about pain medication
Pain is a major healthcare problem. According to the most recent Global Burden of Disease Study, several of the most common conditions are pain problems (such as tension-type headache, migraine and low back pain). Also, pain is the leading cause of disability, with low back pain (first), migraine (second), neck pain (sixth), and other musculoskeletal disorders (seventh) dominating the top ten of most important causes of Years Lived with Disability (YLD).4 (Source: The Journal of Pain)
Source: The Journal of Pain - September 28, 2018 Category: Materials Science Authors: Els Mehuys, Geert Crombez, Koen Paemeleire, Els Adriaens, Thierry Van Hees, Sophie Demarche, Thierry Christiaens, Luc Van Bortel, Inge Van Tongelen, Jean-Paul Remon, Koen Boussery Tags: nOriginal Reports Source Type: research

Determining Pain Catastrophizing from Daily Pain App Assessment Data: Role of Computer-Based Classification
Persons with chronic pain typically report having ‘good and bad’ days with their pain, yet their condition can persist for years.10 Psychological models of chronic pain, such as the fear-avoidance model, demonstrate that the way people cognitively process their pain sensations is a strong determinant of their future pain-related behavior.34 Cat astrophizing is a central variable in the fear-avoidance model that accounts for 7–31% of the variance in pain severity.54 In addition, pain catastrophizing creates maladaptive pain cognitions that can be a risk factor for developing depression, disability, and hig...
Source: The Journal of Pain - September 28, 2018 Category: Materials Science Authors: Robert N. Jamison, Xinling Xu, Limeng Wan, Robert R Edwards, Edgar L. Ross Tags: Original Reports Source Type: research

Identifying and Engaging Neuronal Oscillations by Transcranial Alternating Current Stimulation in Patients with Chronic Low Back Pain: A Randomized, Crossover, Double-Blind, Sham-Controlled Pilot Study
Chronic pain is associated with pathological changes in neuronal activity over somatosensory, insular, cingulate, and prefrontal cortices.46 These brain regions play a fundamental role in the processing of pain.32,51,57 Several electroencephalography (EEG) and magnetoencephalography (MEG) studies have shown that patients with chronic pain exhibit abnormal neuronal oscillations.43,55 In particular, pathologically increased theta oscillations (4-8Hz) 34,48,49,53,58 have motivated a conceptual framework of thalamo-cortical dysrhythmia (TCD) in chronic pain. (Source: The Journal of Pain)
Source: The Journal of Pain - September 27, 2018 Category: Materials Science Authors: Sangtae Ahn, Julianna H. Prim, Morgan L. Alexander, Karen L. McCulloch, Flavio Fr öhlich Tags: Original Reports Source Type: research

The Blind Leading the Not-So-Blind: A Meta-Analysis of Blinding in Pharmacological Trials for Chronic Pain
We examined the rates and predictors of assessing blinding and its success in pharmacological RCTs for chronic pain. Four-hundred eight trials (n  = 103,983 participant) were identified via a systematic search between 2006 and 2016. Only 23 RCTs (5.6%) reported assessing patient blinding. (Source: The Journal of Pain)
Source: The Journal of Pain - September 21, 2018 Category: Materials Science Authors: Ben Colagiuri, Louise Sharpe, Amelia Scott Tags: Review Article Source Type: research

The blind leading the not so blind: a meta-analysis of blinding in pharmacological trials for chronic pain
Randomised controlled trials (RCTs) are the cornerstone of evidence-based interventions both for chronic pain and medicine more generally. In particular, double-blind placebo-controlled RCTs have been heavily relied upon to determine treatment efficacy and safety of chronic pain interventions. Hundreds of double-blind placebo-controlled RCTs are run each year worldwide to test various interventions for chronic pain, with hundreds of thousands of people with chronic pain participating in these trials. (Source: The Journal of Pain)
Source: The Journal of Pain - September 21, 2018 Category: Materials Science Authors: Ben Colagiuri, Louise Sharpe, Amelia Scott Source Type: research

Patients ’ experience with opioid tapering: A conceptual model with recommendations for clinicians
Chronic pain is among the most common complaints in primary care,15 yet patients and clinicians consistently report that negotiating treatment plans for chronic pain is often mutually frustrating and unproductive, especially when treatment involves opioid analgesics.11, 24, 30 Substantial increases in the use of opioids to treat chronic pain during the late 1990s and early 2000s16 and the subsequent rise in rates of opioid-related overdose27, 28 have prompted dramatic shifts in clinical practice away from opioid use. (Source: The Journal of Pain)
Source: The Journal of Pain - September 20, 2018 Category: Materials Science Authors: Stephen G Henry, Debora A Paterniti, Bo Feng, Ana-Maria Iosif, Richard L Kravitz, Gary Weinberg, Penney Cowan, Susan Verba Source Type: research

Alterations in temporal summation of pain and conditioned pain modulation across an episode of experimental exercise-induced low back pain
Low back pain (LBP) is the leading cause of disability worldwide26, yet up to 90% of patients are diagnosed with non-specific LBP, meaning the pathoanatomical source is unclear10. Further, recurrence following an acute episode may be up to 80%25, with little understanding as to why some patients develop ongoing symptoms9. There has recently been increasing focus on alterations in pro-nociceptive and anti-nociceptive mechanisms, purported to explain or contribute to pain exacerbation and persistence across a range of acute to chronic pain conditions34,45,72. (Source: The Journal of Pain)
Source: The Journal of Pain - September 17, 2018 Category: Materials Science Authors: Megan McPhee, Thomas Graven-Nielsen Source Type: research

Contributions of nociresponsive area 3a to normal and abnormal somatosensory perception
Somatosensory cortex in the postcentral gyrus of humans and other primates comprises four cytoarchitectonically, connectionally, and physiologically distinct cortical areas – Brodmann areas 3a, 3b, 1, and 2 (Figure 1AB). Each of these areas forms a long strip running along the central sulcus from the midline to the lateral fissure. The most anterior of these areas, area 3a, lies in the fundus of the central sulcus, flanked anteriorly by motor cortical area 4 and pos teriorly by somatosensory area 3b. (Source: The Journal of Pain)
Source: The Journal of Pain - September 15, 2018 Category: Materials Science Authors: Barry L. Whitsel, Charles J. Vierck, Robert S. Waters, Mark Tommerdahl, Oleg V. Favorov Tags: Review Article Source Type: research

A novel finger illusion reveals reduced weighting of bimanual hand cortical representations in people with complex regional pain syndrome
Complex regional pain syndrome (CRPS) is characterised by excessive pain, usually in a peripheral limb such as the hand, and affects sensation, movement and function.32 Quantified deficits include higher thresholds for two-point discrimination in the index finger,45 impaired hand size estimation,35,44 finger misidentification,14,33 tactile processing disturbances;28 errors in bilateral limb positioning,30 fine motor26 and motor imagery performance.34,49,50 These deficits implicate distortions in body representation53 and are corroborated by evidence of cortical re-organisation in CRPS,9,10 although much remains unclear. (S...
Source: The Journal of Pain - September 14, 2018 Category: Materials Science Authors: Audrey P Wang, Annie A Butler, John D Valentine, Caroline D Rae, James McAuley, Simon C Gandevia, G Lorimer Moseley Tags: Original Reports Source Type: research

Higher Dispositional Optimism Predicts Lower Pain Reduction During Conditioned Pain Modulation
Optimism, or a generalized expectancy for positive outcomes, is associated with lower pain sensitivity, higher placebo analgesia, and better adjustment to chronic pain [8,9,26]. The initial conceptualization of optimism was developed from a broader model of behavioral self- regulation [10,32,33]. Based on this model, optimists are people who expect positive outcomes, making them more likely to engage in health promoting behaviors [33]. While optimism is viewed as a stable individual personality difference, it is also associated with coping strategies and positive affect, which lead to better health outcomes [10,26,31]. (So...
Source: The Journal of Pain - September 13, 2018 Category: Materials Science Authors: Caroline E. Hinkle, Raimi L. Quiton Source Type: research

Design and reporting characteristics of clinical trials of select chronic and recurrent pediatric pain conditions: An ACTTION systematic review
Chronic and recurrent pain are common in the pediatric population, with median prevalences ranging from 11-38% reported in the literature depending on the type of pain and criteria used to define chronic and recurrent pain.25 However, a paucity of clinical trials is available that provide adequate evidence to inform pediatric pain management and evidence-based treatment guidelines.13 Many of the current pediatric pain treatment recommendations, therefore, rely on efficacy data extrapolated from studies that included only adults. (Source: The Journal of Pain)
Source: The Journal of Pain - September 13, 2018 Category: Materials Science Authors: Marina R. Connolly, Jenna Y. Chaudari, Ximeng Yang, Nam Ward, Rachel A. Kitt, Rachel S. Herrmann, Elliot J. Krane, Alyssa A. LeBel, Shannon M. Smith, Gary A. Walco, Steven J. Weisman, Dennis C. Turk, Robert H. Dworkin, Jennifer S. Gewandter Tags: Review Article Source Type: research

Impact of Chronic Opioid Therapy Risk Reduction Initiatives on Opioid Overdose
From 1999 to 2015, almost 200,000 Americans died of drug overdoses involving prescription opioids19,24 contributing to an unprecedented drop in life expectancy among working age Americans.3 Increased opioid prescribing for chronic pain contributed to a national epidemic of prescription drug overdose and addiction.16 (Source: The Journal of Pain)
Source: The Journal of Pain - September 3, 2018 Category: Materials Science Authors: Michael Von Korff, Kathleen Saunders, Sascha Dublin, Rod L. Walker, Manu Thakral, Karen J Sherman, Evette J. Ludman, Ryan N. Hansen, Michael Parchman, Susan M. Shortreed Source Type: research

Examining injustice appraisals in a racially diverse sample of individuals with chronic low back pain
Within the United States, low back pain (LBP) is a leading cause of pain24,93 and disability,20,33,74 accounting for 52 million of all healthcare visits.20,93 Although most LBP resolves quickly, up to 10% develop a chronic and disabling pain condition.41 In turn, chronic LBP (CLBP) contributes to annual costs of nearly $300 billion, due substantially to lost wages and productivity.25,47,93 Despite medical advances,30,50 the cost and incidence of CLBP are steadily on the rise.20,36,50 (Source: The Journal of Pain)
Source: The Journal of Pain - September 1, 2018 Category: Materials Science Authors: Zina Trost, John Sturgeon, Adam Guck, Maisa Ziadni, Liza Nowlin, Burel Goodin, Whitney Scott Tags: Original Reports Source Type: research

Masthead
(Source: The Journal of Pain)
Source: The Journal of Pain - August 30, 2018 Category: Materials Science Source Type: research

Editorial Board
(Source: The Journal of Pain)
Source: The Journal of Pain - August 30, 2018 Category: Materials Science Source Type: research

Table of Contents
(Source: The Journal of Pain)
Source: The Journal of Pain - August 30, 2018 Category: Materials Science Source Type: research

Validation of a Limitations in Daily Activities Scale for Chronic Pain
International estimates place the prevalence of chronic pain at about 18 to 30% of adults in the community, most of whom report at least some pain-related interference with activities.7,23,48 Further, recent U.S. data indicate that, of the 5 most common disorders contributing to years lived with disability, positions 1, 3, and 4 are occupied by back pain, other musculoskeletal disorders, and neck pain, respectively.60 With such a high burden of functional disability, it is important for both clinical and research purposes that there be reliable and valid measures for the assessment of activity limitations caused by chronic...
Source: The Journal of Pain - August 30, 2018 Category: Materials Science Authors: Keith G. Wilson, Dyana Castillo, John Kowal, An Gie Yong, Lachlan A. McWilliams Tags: Original Report Source Type: research

Deployment-related Traumatic Brain Injury and Risk of New Episodes of Care for Back Pain in Veterans
The United States (US) Department of Veterans Affairs (VA) and the Department of Defense (DOD) define traumatic brain injury (TBI) as a structural injury and/or physiological disruption in brain function as the result of an external force, indicated by the onset or worsening of clinical signs immediately following the event.9 The diagnosis of TBI was made in more than 375,000 US military service members between 2000 and 2017.8 A systematic review found that chronic pain is common following TBI, and that prevalence of chronic pain differed by TBI severity (mild vs. (Source: The Journal of Pain)
Source: The Journal of Pain - August 30, 2018 Category: Materials Science Authors: Pradeep Suri, Kelly Stolzmann, Rhonda Williams, Terri K. Pogoda Tags: Original Reports Source Type: research

Validation of a Limitations in Daily Activities Scale (LIDAS) for Chronic Pain
International estimates place the prevalence of chronic pain at about 18% to 30% of adults in the community, most of whom report at least some pain-related interference with activities.7,23,48 Further, recent U.S data indicate that of the five most common disorders contributing to years lived with disability, positions 1, 3 and 4 are occupied by back pain, other musculoskeletal disorders, and neck pain, respectively.60 With such a high burden of functional disability, it is important for both clinical and research purposes that there be reliable and valid measures for the assessment of activity limitations caused by chroni...
Source: The Journal of Pain - August 30, 2018 Category: Materials Science Authors: Keith G. Wilson, Dyana Castillo, John Kowal, An Gie Yong, Lachlan A. McWilliams Source Type: research

Widespread Pressure Pain Hypersensitivity in Musculoskeletal and Nerve Trunk Areas as a Sign of Altered Nociceptive Processing in Unilateral Plantar Heel Pain
Plantar heel pain is a foot condition commonly treated by health care providers.16 Subjectswith this condition report insidious sharp pain under the plantar surface of the heel, usually spreading from the medial border of the plantar fascia to its insertion at the medial tuberosity of the calcaneus.1 The pain increases in the morning with the first step after getting out of bed, after prolonged periods of inactivity, and/or at the beginning of a workout.3 Owing to the presence of degenerative changes and the absence of inflammation in the plantar fascia,14 it has been proposed that the proper term for this pain condition i...
Source: The Journal of Pain - August 16, 2018 Category: Materials Science Authors: Gustavo Plaza-Manzano, Marta R íos-León, Patricia Martín-Casas, Lars Arendt-Nielsen, César Fernández-de-las-Peñas, Ricardo Ortega-Santiago Tags: Original Reports Source Type: research

Widespread Pressure Pain Hypersensitivity in Musculoskeletal and Nerve Trunk Areas as Sign of Altered Nociceptive Processing in Unilateral Plantar Heel Pain
Plantar heel pain is a foot condition commonly treated by healthcare providers16. Subjects with this condition report insidious sharp pain under the plantar surface of the heel, usually spreading from the medial border of the plantar fascia to its insertion at the medial tuberosity of the calcaneus1. The pain increases in the morning with the first step after getting out of bed, after prolonged periods of inactivity and/or at the beginning of a workout3. Due to the presence of degenerative changes and the absence of inflammation in the plantar fascia14, it has been proposed that the proper term for this pain condition is p...
Source: The Journal of Pain - August 16, 2018 Category: Materials Science Authors: Gustavo Plaza-Manzano, Marta R íos-León, Patricia Martín-Casas, Lars Arendt-Nielsen, César Fernández-de-las-Peñas, Ricardo Ortega-Santiago Source Type: research

Risk of Pain and Gastrointestinal Complaints at 6Months After Elective Abdominal Surgery
The incidence of chronic postoperative abdominal pain (CPAP) after abdominal surgery is estimated at 11%. CPAP is associated with an increase of gastrointestinal symptoms and decreases overall quality of life.5,10 Around 30% of patients after gastrointestinal surgery report having pain-related interference with mood, sleep, and enjoyment of life and 12% visit the emergency department for pain-related symptoms.36 Intra-abdominal adhesions are deemed as the cause of CPAP in 60% of patients. In these patients, no anatomic or functional abnormalities are found apart from adhesions. (Source: The Journal of Pain)
Source: The Journal of Pain - August 11, 2018 Category: Materials Science Authors: Chema Strik, Barend van den Beukel, Dagmar van Rijckevorsel, Martijn W.J. Stommel, Richard P.G. ten Broek, Harry van Goor Tags: Original Reports Source Type: research

Risk of pain and gastrointestinal complaints at six months after elective abdominal surgery
The incidence of chronic postoperative abdominal pain (CPAP) after abdominal surgery is estimated at 11%. CPAP is associated with an increase of gastrointestinal symptoms and decreases overall quality of life 5, 10. Around 30% of patients after gastrointestinal surgery report having pain-related interference with mood, sleep and enjoyment of life and 12% visit the emergency department for pain related symptoms 36. Intra-abdominal adhesions are deemed as the cause of CPAP in 60% of patients. In these patients no anatomic or functional abnormalities are found apart from adhesions 32. (Source: The Journal of Pain)
Source: The Journal of Pain - August 11, 2018 Category: Materials Science Authors: Chema Strik, Barend van den Beukel, Dagmar van Rijckevorsel, Martijn W.J. Stommel, Richard P.G. ten Broek, Harry van Goor Source Type: research

Cost-effectiveness and cost-utility of internet-delivered exposure therapy for fibromyalgia: results from a randomized controlled trial
Fibromyalgia (FM) is a disabling chronic pain disorder, with a prevalence ranging between 2 and 4% 25,53,57, often presenting with a range of other somatic and psychiatric symptoms such as fatigue, sleep disturbances, anxiety and depression. Furthermore, FM is a costly disorder for both healthcare providers and society. One study 7 showed that FM patients on average utilize four times as many physician visits, twice as many other outpatient visits, and four times more emergency room visits compared with other primary care patients. (Source: The Journal of Pain)
Source: The Journal of Pain - August 11, 2018 Category: Materials Science Authors: Maria Hedman-Lagerl öf, Erik Hedman-Lagerlöf, Brjánn Ljótsson, Rikard K Wicksell, Ida Flink, Erik Andersson Tags: Original Reports Source Type: research

Spinal Serotonin 1A Receptor Contributes to the Analgesia of Acupoint Catgut Embedding by Inhibiting Phosphorylation of the N-Methyl-d-Aspartate Receptor GluN1 Subunit in Complete Freund's Adjuvant-Induced Inflammatory Pain in Rats
Acupoint catgut embedding (ACE) is a widely used traditional Chinese medicine method to manage various diseases, including chronic inflammatory pain. We sought to assess the possible analgesic effects of ACE in comparison with electroacupuncture (EA) and to study the analgesic mechanisms of ACE in a rat model of inflammatory pain induced by injection of complete Freund's adjuvant (CFA) into the hind paw of rats. The von Frey, radiant heat, and gait analysis tests were performed to evaluate the analgesic effects of ACE and EA, and Western blot and immunohistochemistry assays were carried out to determine the molecular mecha...
Source: The Journal of Pain - August 10, 2018 Category: Materials Science Authors: Wen-Qiang Cui, Wen-Shan Sun, Fei Xu, Xue-Ming Hu, Wei Yang, Yang Zhou, Li-Xia Du, Wen-Wen Zhang, Qi-Liang Mao-Ying, Wen-Li Mi, Yu-Xia Chu, Yan-Qing Wang Source Type: research