Fecal Microbiota Transplantation Improves Clinical Symptoms of Fibromyalgia: An open-label, Randomized, Nonplacebo-Controlled Study
This study was aimed to investigate the potential benefits of fecal microbiota transplantation (FMT) in patients with FM. A total of 45 patients completed this open-label randomized, nonplacebo-controlled clinical study. The Numerical Rating Scale (NRS) scores in the FMT group were slightly lower than the control group at 1 month (P> 0.05), and they decreased significantly at 2, 3, 6, and 12 months after treatment (P (Source: The Journal of Pain)
Source: The Journal of Pain - April 23, 2024 Category: Materials Science Authors: Hongwei Fang, Qianhao Hou, Wei Zhang, Zehua Su, Jinyuan Zhang, Jingze Li, Jiaqi Lin, Zetian Wang, Xiuqin Yu, Yu Yang, Qing Wang, Xin Li, Yuling Li, Lungui Hu, Shun Li, Xiangrui Wang, Lijun Liao Source Type: research
Interactions Between Endocannabinoid and Endogenous Opioid Systems Prospectively Influence Postoperative Opioid Use in Pregnant Patients Undergoing Cesarean Delivery
This study evaluated the interactive effects of preoperative beta-endorphin concentrations (a key analgesic endogenous opioid) in cerebrospinal fluid (CSF) and ECs (CSF and plasma 2-arachidonoylglycerol [2-AG] and plasma anandamide [AEA]) on postoperative opioid use and pain intensity in a prospective cohort of n = 112 pregnant patients undergoing scheduled cesarean delivery. (Source: The Journal of Pain)
Source: The Journal of Pain - April 23, 2024 Category: Materials Science Authors: Amanda L. Stone, Amelie Pham, Sarah S. Osmundson, Alex Pedowitz, Philip J. Kingsley, Larry J. Marnett, Sachin Patel, Nancy Wickersham, Laura L. Sorabella, Stephen Bruehl Source Type: research
Pain catastrophizing moderates the relationship between pain sensitivity and clinical pain in adolescents with functional abdominal pain
Pain catastrophizing has been linked to amplified pain sensitivity assessed using quantitative sensory testing (QST) in adults; pediatric data is limited, particularly in youth with functional abdominal pain (FAP). With increasing use of QST to evaluate somatosensory function and predict pain outcomes, we examined the associations between QST and clinical pain in adolescents with FAP and tested the moderating effects of pain catastrophizing. Seventy-seven adolescents (mean age 16.6 years, 85.7% female, 72.7% White, 90.8% non-Hispanic) who fulfilled diagnostic criteria for FAP completed QST assessment (pressure pain thresho...
Source: The Journal of Pain - April 22, 2024 Category: Materials Science Authors: See Wan Tham, Rui Li, Robert R. Edwards, Tonya M. Palermo Source Type: research
Subcutaneous Oxytocin Injection Reduces Heat Pain: A randomized-controlled trial
Oxytocin 1 is a neuropeptide broadly implicated in social relationships and behavior. OT also exerts antinociceptive and pain-reducing effects in both humans and rodents. Recent research in rodents demonstrates that these effects can be peripheral and local. In human studies, intravenous OT has reduced visceral pain and subcutaneous injection of OT has reduced postsurgical pain. However, the local effects of subcutaneous OT on experimental pain have not been studied. We conducted a two-session crossover study during which healthy adults received a subcutaneous injection of synthetic OT (4mcg/2ml) or saline placebo (isotoni...
Source: The Journal of Pain - April 18, 2024 Category: Materials Science Authors: Benedetta Albinni, Marisa Zimmerman, Jacob Ross, Leyla Ozdoyuran, Vincent Alasha, Nathaniel M. Schuster, Engy Said, Laura Case Source Type: research
Pre-treatment brain white matter integrity associated with neuropathic pain relief and changes in temporal summation of pain following ketamine
Neuropathic pain (NP) is a prevalent condition often associated with heightened pain responsiveness suggestive of central sensitization. Neuroimaging biomarkers of treatment outcomes may help develop personalised treatment strategies, but white matter (WM) properties have been under-explored for this purpose. Here we assessed whether WM pathways of the default mode network (DMN: medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), precuneus (PCu)) and descending pain modulation system (periaqueductal gray (PAG)) are associated with ketamine analgesia and attenuated temporal summation of pain (TSP, reflecting ...
Source: The Journal of Pain - April 12, 2024 Category: Materials Science Authors: Emily P. Mills, Rachael L. Bosma, Anton Rogachov, Joshua C. Cheng, Natalie R. Osborne, Junseok A. Kim, Ariana Besik, Anuj Bhatia, Karen D. Davis Tags: Original Reports Source Type: research
Impact of Shared Decision-Making on Opioid Prescribing Among Patients with Chronic Pain: A Retrospective Cohort Study
This study measured whether SDM affects opioid prescribing frequency for chronic low back pain. A retrospective cohort study involving 1478 participants was conducted within a national pain research registry. The patient participation and patient orientation (PPPO) scale of the Communication Behavior Questionnaire was used to measure SDM, including classification of greater SDM (PPPO scale score ≥80) or lesser SDM (PPPO scale score (Source: The Journal of Pain)
Source: The Journal of Pain - April 11, 2024 Category: Materials Science Authors: John C. Licciardone, Braden Van Alfen, Michaela N. Digilio, Rylan Fowers, Bassam Ballout, Yasser Bibi, Subhash Aryal Source Type: research
Peer victimization, posttraumatic stress symptoms, and chronic pain: A longitudinal examination
Chronic pain and posttraumatic stress disorder symptoms (PTSS) co-occur at high rates in youth and are linked to worse pain outcomes and quality of life. While peer victimization has been posited as a mechanism underlying the PTSS-pain relationship in youth, empirical evidence suggests that it may exacerbate both PTSS and pain. The present study aimed to longitudinally examine PTSS as a mediator in the relationship between peer victimization at baseline and pain-related outcomes at 3 months in youth with chronic pain. (Source: The Journal of Pain)
Source: The Journal of Pain - April 11, 2024 Category: Materials Science Authors: C. Nania, S.E. Noyek, S. Soltani, J. Katz, J. Fales, K.A. Birnie, S.L. Orr, C.A. McMorris, M. Noel Tags: Original Reports Source Type: research
Examining the role of structural and functional social network characteristics in the context of chronic pain: An ego-centered network design
The well-being and functioning of individuals with chronic pain (CP) varies significantly. Social factors, such as social integration, may help explain this differential impact. Specifically, structural (network size, density) as well as functional (perceived social support, conflict) social network characteristics may play a role. However, it is not yet clear whether and how these variables are associated with each other. Objectives were to examine: (1) both social network characteristics in individuals with primary and secondary CP, (2) the association between structural network characteristics and mental distress, and f...
Source: The Journal of Pain - April 10, 2024 Category: Materials Science Authors: Mait é Van Alboom, Fleur Baert, Sónia F. Bernardes, Lesley Verhofstadt, Piet Bracke, Mingshan Jia, Katarzyna Musial, Bogdan Gabrys, Liesbet Goubert Source Type: research
Latent Profile Analysis of Canadian Military Veterans with Chronic Pain Identifies 5 Meaningful Classes through Self-Report Measures
The purpose of this study was to identify meaningful response patterns in self-report survey data collected from Canadian military veterans with chronic pain and to create an algorithm intended to facilitate triage and prioritization of veterans to the most appropriate interventions. An online survey was presented to former members of the Canadian military who self-identified as having chronic pain. Variables collected were related to pain, physical and mental interference, prior traumatic experiences, and indicators from each of seven potential drivers of the pain experience. (Source: The Journal of Pain)
Source: The Journal of Pain - April 9, 2024 Category: Materials Science Authors: David M. Walton, Pavlos Bobos, Joy C. MacDermid Source Type: research
Prevalence and biopsychosocial factors associated with a current episode of low back pain amongst adults with previous history of low back pain: a cross-sectional study of market traders in an African population
Low back pain (LBP) is the leading cause of years lived with disability globally, with Nigeria having one of the greatest burdens. A current episode of LBP is important in Nigeria, but the associated factors are unknown. This cross-sectional study investigated the prevalence, biomechanical and psychosocial factors associated with a current episode of LBP amongst 700 adult market traders with previous LBP in an urban Nigerian population. Descriptive, bivariate, and multivariate analyses were conducted. (Source: The Journal of Pain)
Source: The Journal of Pain - April 8, 2024 Category: Materials Science Authors: Chinonso Nwamaka Igwesi-Chidobe, Confidence N Ifeanyichukwu, Joshua P Okorie, Muhammad Faisal, Benjamin C Ozumba Source Type: research
Body image measured via the Fremantle Awareness Questionnaire in individuals with and without pain: a systematic review and meta-analysis
Research suggests that pain negatively affects body image, and body image may also influence reported pain levels. This review aims to summarize the literature on differences in body image distortion between individuals with pain compared to pain-free individuals. The review was conducted according to the PRISMA 2020 statement and an a priori pre-registered protocol. The literature was searched using five electronic databases. Studies assessing body image with the Fremantle Awareness Questionnaire (FAQ) in individuals with and without pain were eligible for inclusion. (Source: The Journal of Pain)
Source: The Journal of Pain - April 8, 2024 Category: Materials Science Authors: Aleksandra Budzisz, Andres Jung, Waclaw M. Adamczyk, Tibor M. Szikszay, Gabriela F. Carvalho, Przemys ław Bąbel, Kerstin Luedtke Tags: Review Article Source Type: research
Perioperative Risk Factors for Persistent Postsurgical Pain after Inguinal Hernia Repair: Systematic Review and Meta-analysis
The objective of this study was to systematically review and meta-analyze risk factors that contribute to PPSP after IHR. The literature search resulted in 303 papers included in this review, 140 of which were used for meta-analyses. (Source: The Journal of Pain)
Source: The Journal of Pain - April 8, 2024 Category: Materials Science Authors: Harutyun Alaverdyan, Jooyoung Maeng, Peter K Park, Kavya Narayana Reddy, Michael P Gaume, Lauren Yaeger, Michael M. Awad, Simon Haroutounian Tags: Review Article Source Type: research
Assessment of human fetuses undergoing acute pain: validation of the fetal-7 scale
Improvements in fetal ultrasound have allowed for the diagnosis and treatment of fetal diseases in the uterus, often though surgery. However, little attention has been drawn to the assessment of fetal pain. To address this gap, a fetal pain scoring system, known as the Fetal-7 scale, was developed. The present study is a full validation of the Fetal-7 scale. The validation involved two steps: i. four fetuses with indication of surgery were evaluated in three conditions perioperatively: acute pain, rest, and under loud sound stimulation. (Source: The Journal of Pain)
Source: The Journal of Pain - April 7, 2024 Category: Materials Science Authors: Lisandra Stein Bernardes, Ana M ércia Fernandes, Mariana Azevedo de Carvalho, Juliana Ottolia, Michele Hamani, Inaeh Oliveira, Gabriel Taricani Kubota, Valquíria Aparecida da Silva, Adriano Veloso, Mario Henrique Burlachini de Cavalho, Antônio Gomes de Source Type: research
Evaluating Sensitization-Associated, Neuropathic-Like Symptoms and Psychological Factors in Patients with Interstitial Lung Disease
The aims of this study were to phenotype pain in patients with interstitial lung disease (ILD) by investigating the association between sensitization-associated symptoms with quality of life, anxiety/depression, pain catastrophizing and kinesiophobia levels, and, identifying those risk factors explaining the variance of quality of life in individuals with ILD and pain. One hundred and thirty-two (38.6% women, mean age: 70, SD: 10.5 years) patients with ILD completed clinical (age, sex, height, weight), psychological (Hospital Anxiety and Depression Scale, HADS and the Pittsburgh Sleep Quality Index, PSQI), and health-relat...
Source: The Journal of Pain - April 7, 2024 Category: Materials Science Authors: Paula Par ás-Bravo, César Fernández-de-las-Peñas, Diego Ferrer-Pargada, Patricia Druet-Toquero, Luis M. Fernández-Cacho, José M. Cifrián-Martínez, Lars Arendt-Nielsen, Manuel Herrero-Montes Source Type: research
Risk of Unfavorable Trajectories of Chronic Pain Severity – Results of a Longitudinal Study in School Children
Chronic pain is a common burden among children and adolescents associated with impairments in many aspects of life. Higher pain severity increases this burden. Subsequently, it is important to identify factors predicting the course of pain severity, classified by the Chronic Pain Grading. In a 1-year longitudinal assessment of a general school-age population (N=2280), we aimed to identify biopsychosocial factors associated with Chronic Pain Grading trajectories. We focused on children and adolescents who reported chronic pain at the start of the year (N=689). (Source: The Journal of Pain)
Source: The Journal of Pain - April 6, 2024 Category: Materials Science Authors: Clarissa Humberg, Lisa-Marie Rau, Benedikt B. Claus, Anna K önning, Lorin Stahlschmidt, Julia Wager Source Type: research
