AAPT Diagnostic Criteria for Chronic Low Back Pain
Chronic low back pain conditions are highly prevalent and constitute the leading cause of disability worldwide. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION) public-private partnership with the US Food and Drug Administration and the American Pain Society (APS), have combined to create the ACTTION-APS Pain Taxonomy (AAPT). The AAPT initiative convened a working group to develop diagnostic criteria for chronic low back pain. The working group identified three distinct low back pain conditions which result in a vast public health burden across the lifesp...
Source: The Journal of Pain - February 6, 2020 Category: Materials Science Authors: John D. Markman, Katarzyna Czerniecka-Foxx, Partap S. Khalsa, Salim Michel Hayek, Anthony L. Asher, John D. Loeser, Roger Chou Source Type: research

AAAPT Diagnostic Criteria for ACUTE ABDOMINAL AND PERITONEAL PAIN AFTER SURGERY
Abdominal and peritoneal pain after surgery is common and burdensome, yet the lack of standardized diagnostic criteria for this type of acute pain impedes basic, translational, and clinical investigations. The collaborative effort among the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION), American Pain Society (APS), and American Academy of Pain Medicine (AAPM) Pain Taxonomy (AAAPT) provides a systematic framework to classify acute painful conditions. (Source: The Journal of Pain)
Source: The Journal of Pain - January 29, 2020 Category: Materials Science Authors: Mark C. Bicket, Michael C. Grant, Michael J. Scott, Gregory W. Terman, Elizabeth C. Wick, Christopher L. Wu Tags: Focus Article Source Type: research

Evolution of Analgesic Tolerance and Opioid-Induced Hyperalgesia over 6 months: Double-blind randomized trial incorporating experimental pain models
Contributors to the ongoing epidemic of prescription opioid abuse, addiction, and death include opioid tolerance, withdrawal symptoms, and possibly opioid-induced hyperalgesia (OIH). Thirty stable chronic non-malignant pain patients entered a six-month long, randomized, double-blind, dose-response, two-center trial of the potent opioid levorphanol, conducted over a decade ago during an era of permissive opioid prescribing. Eleven were taking no opioids at study entry and eleven were taking between 35-122 morphine equivalents (MEQ). (Source: The Journal of Pain)
Source: The Journal of Pain - January 29, 2020 Category: Materials Science Authors: Michael C. Rowbotham, Mark Wallace Tags: Original Reports Source Type: research

Biased partner perceptions of women's pain self-efficacy in postpartum pain during intercourse: A dyadic longitudinal examination
Childbirth is a significant risk factor for the development of persistent pain problems (e.g., 9, 28, 85), including pain during intercourse 14, 17, 34, 53, 62. Approximately 37% of women report pain during intercourse at three months postpartum, which persists for 31% at six months postpartum 73. Pain during intercourse substantially interferes with couples ’ sexual functioning, and in turn, their quality of life (e.g., 63, 73, 81). Biomedical factors such as mode of delivery and severity of delivery pain have been implicated in the persistence of this pain in the first six months postpartum73. (Source: The Journal of Pain)
Source: The Journal of Pain - January 29, 2020 Category: Materials Science Authors: Meghan A. Rossi, Jessica A. Maxwell, Natalie O. Rosen Tags: Original Reports Source Type: research

Electroacupuncture Alleviates Mechanical Allodynia in a Rat Model of Complex Regional Pain Syndrome Type-I via Suppressing Spinal CXCL12/CXCR4 Signaling
Complex regional pain syndrome (CRPS) is a chronic neurological dysfunction that usually affects the extremities of the patients 30. Trauma, bone fractures, nerve lesions and ischemia are usually among the major reasons that lead to CRPS 2,7,32. CRPS can be subdivided into two categories: type-I CRPS (CRPS-I), without overt nerve damage and type-II CRPS (CRPS-II), with identifiable nerve damage 32. CRPS patients usually suffer from excruciating and chronic pain in affected areas, leading even to disabilities 31. (Source: The Journal of Pain)
Source: The Journal of Pain - January 29, 2020 Category: Materials Science Authors: Qimiao Hu, Xiaoli Zheng, Xiaojie Li, Boyu Liu, Chengyu Yin, Yuanyuan Li, Ruixiang Chen, Jie Wang, Yi Liang, Xiaomei Shao, Jianqiao Fang, Boyi Liu Tags: Original Reports Source Type: research

Cupping for patients with chronic pain: a systematic review and meta-analysis
Low back pain, neck pain and other musculoskeletal disorders are among the ten leading causes of years lived with disability worldwide in 2016.12 Despite the wide range of treatments and health care resources devoted to low back pain, back-related disability and population burden have increased 10,11,14 and this development has recently called for international action.2 Since the US opioid crisis, the value of analgesics in general and of opioids in particular in the treatment of chronic pain is under discussion. (Source: The Journal of Pain)
Source: The Journal of Pain - January 23, 2020 Category: Materials Science Authors: H. Cramer, P. Klose, M. Teut, G. Rotter, M. Ortiz, D. Anheyer, K. Linde, B. Brinkhaus Tags: Review Article Source Type: research

Is transcranial direct current stimulation (tDCS) effective for the treatment of pain in fibromyalgia? A systematic review and meta-analysis
Fibromyalgia is a debilitating chronic pain condition affecting approximately 5.4% of the UK population.19 Its primary symptoms include: chronic widespread muscle pain, fatigue, sleep disturbances, tenderness (allodynia) and hyperalgesia to pressure over tender points.53,54 Its pathogenesis is uncertain but may be due to dysfunction of the central nervous system (CNS)31, possibly related to abnormal processing of pain expectation amongst other CNS abnormalities.8 Current treatments include: antidepressant and antiepileptic medication, exercise, cognitive behavioral therapy (CBT) and patient education. (Source: The Journal of Pain)
Source: The Journal of Pain - January 23, 2020 Category: Materials Science Authors: Donna M. Lloyd, Priscilla G. Wittkopf, Laura J. Arendsen, Anthony K.P. Jones Tags: Review Article Source Type: research

Five-year Pain Intensity and Treatment Trajectories of Post-9/11 Veterans with Mild Traumatic Brain Injury
Patterns of multimorbidity exist in Post-9/11 Veterans deployed in support of the Global War on Terror.30 In 2009, approximately 40% of Post-9/11 Veterans were diagnosed with some type of pain, but only half of those individuals had pain without traumatic brain injury (TBI) or posttraumatic stress disorder (PTSD).7 Among those with diagnosed TBI, over 60% had one or more comorbid pain diagnoses demonstrating the co-occurrence of pain and TBI.7 Pain in the context of TBI can be due to physical trauma or overuse injuries and may be driven by musculoskeletal, neuropathic, and central mechanisms. (Source: The Journal of Pain)
Source: The Journal of Pain - January 22, 2020 Category: Materials Science Authors: Kangwon Song, Chen-Pin Wang, Donald D. McGeary, Carlos A. Jaramillo, Blessen C. Eapen, Megan Amuan, Cindy A. McGeary, Jennifer S. Potter, Mary Jo V. Pugh Tags: Original Reports Source Type: research

Can slow deep breathing reduce pain? An experimental study exploring mechanisms
Slow deep breathing (SDB) is a common complementary treatment strategy to manage pain.2 Despite its wide use and some promising findings, evidence for its efficacy remains equivocal. Also the exact working mechanisms remain unestablished.28 Distraction, emotion modulation, and expectations induced by voluntary SDB have been proposed among the most viable potential top-down mechanisms.28 Another class of potential mechanisms relate to the profound impact of SDB on the cardiovascular system, including an augmentation of cardiac vagal activity and the baroreflex. (Source: The Journal of Pain)
Source: The Journal of Pain - January 21, 2020 Category: Materials Science Authors: Hassan Jafari, Ali Gholamrezaei, Mathijs Franssen, Lukas Van Oudenhove, Qasim Aziz, Omer Van den Bergh, Johan W.S. Vlaeyen, Ilse Van Diest Tags: Original Reports Source Type: research

Dynorphin and Enkephalin Opioid Peptides and Transcripts in Spinal Cord and Dorsal Root Ganglion During Peripheral Inflammatory Hyperalgesia and Allodynia
Opioids are among the most effective analgesics in use, acting at receptors for endogenous opioid neuropeptides in spinal cord and in higher brain regions. These opioid peptides are also regulated in response to persistent pain states, participating in the complex plasticities that induce hyperalgesia, guarding, and other alterations associated with sustained nociceptive input. Enhancement of the opioid peptide precursor prodynorphin (Pdyn) mRNA levels31,38,62 in the dorsal spinal cord has been extensively described in response to persistent painful conditions,47,67 and is preceded by activation of transcriptional mechanis...
Source: The Journal of Pain - January 10, 2020 Category: Materials Science Authors: Matthew R. Sapio, Michael J. Iadarola, Amelia J. Loydpierson, Jenny J. Kim, Danielle Thierry-Mieg, Jean Thierry-Mieg, Dragan Maric, Andrew J. Mannes Tags: Original Reports Source Type: research

Alternative splicing of Nrcam gene in dorsal root ganglion contributes to neuropathic pain
Neuropathic pain is a very common clinical disorder, usually caused by nerve injury or accompanying some diseases (such as diabetes). It reduces the quality of life in patients due to a lack of effective analgesic strategies. The altered gene/protein expression in primary sensory neurons following injury has been demonstrated as the key component of the pathophysiology of neuropathic pain 16,17,29,40,41. A next generation RNA sequencing analysis revealed the differential expression of thousands of genes in the injured DRG caused by spinal nerve ligation (SNL) 35. (Source: The Journal of Pain)
Source: The Journal of Pain - January 6, 2020 Category: Materials Science Authors: Lingli Liang, Shaogen Wu, Corinna Lin, Yun-Juan Chang, Yuan-Xiang Tao Tags: Original Reports Source Type: research

Multisensorial perception in chronic migraine and the role of medication overuse
Coherent, unambiguous and stable perceptual experiences result from the ability to merge concurrent information provided by different senses26,43,50,72. Multisensory integration occurs when stimuli from different sensory systems are combined in close temporal or spatial proximity, improving their detection2,12,25,50,76. However, we experience illusory percepts whenever sensory inputs from different modalities are incoherent45,53,76,80,90. Crossmodal illusions represent useful paradigms to assess how multisensory integration affects sensory perception in healthy and pathological conditions17,77,78, as shown by the Sound-Ind...
Source: The Journal of Pain - January 5, 2020 Category: Materials Science Authors: Simona Maccora, Nadia Bolognini, Giuseppe Cosentino, Roberta Baschi, Giuseppe Vallar, Brigida Fierro, Filippo Brighina Tags: Original Reports Source Type: research

The Endogenous Analgesia Signature in The Resting Brain of Healthy Adults and Migraineurs
Imaging studies link migraine pathophysiology to functional abnormalities in pain modulatory brain areas.57,75 When interictal migraineurs are exposed to evoked pain, the pain-modulatory areas become hyperactive, and the level of hyperactivity is associated with attack frequency and pain intensity.56,63,81,96 Migraineurs also exhibit an association between migraine clinical characteristics, and altered resting-state functional connectivity (rsFC) of mesencephalic, cingulate, insular and prefrontal brain areas involved in affective processing and descending inhibition of pain. (Source: The Journal of Pain)
Source: The Journal of Pain - January 2, 2020 Category: Materials Science Authors: Yuval Argaman, Lee B. Kisler, Yelena Granovsky, Robert C. Coghill, Elliot Sprecher, David Manor, Irit Weissman-Fogel Tags: Original Reports Source Type: research

Parental multi-site chronic pain and the risk of adult offspring developing additional chronic pain sites: family-linkage data from the Norwegian HUNT Study
Musculoskeletal pain is associated with substantial disability and a large financial burden worldwide49,71,5,70. For example, the total yearly costs of musculoskeletal pain in Australia is estimated at $55 billion4, while in Europe, the yearly costs of back pain are estimated as high as €300 billion 71. Low back and neck pain are among the most prevalent and disabling musculoskeletal conditions70 (global point-prevalence of 9.4%27 and 4.9%28, respectively), however, approximately one in ten individuals (during their life) will experience chronic musculoskeletal pain in multiple b ody areas73,50,3 and report even great...
Source: The Journal of Pain - January 2, 2020 Category: Materials Science Authors: Joshua R. Zadro, Tom Ivar Lund Nilsen, Debra Shirley, Anita B. Amorim, Paulo H. Ferreira, Ragnhild Lier, Paul Jarle Mork Tags: Original Reports Source Type: research

Doctor recommendations are related to patient interest and use of behavioral treatment for chronic pain and addiction
Chronic pain is one of the most debilitating, difficult to treat, chronic health conditions and affects at least 20% of the American adult population.7 In addition to the direct impact on quality of life via health consequences, chronic pain is widely believed to be causally related to the current opioid epidemic.24 (Source: The Journal of Pain)
Source: The Journal of Pain - January 2, 2020 Category: Materials Science Authors: Alexandria Brunkow, Margeaux Cannon, Fiona S. Graff, Jessica L. Martin, Leslie R.M. Hausmann, Lisa M McAndrew Tags: Original Reports Source Type: research

Biopsychosocial Influences on Shoulder Pain: Analyzing the Temporal Ordering of Post-Operative Recovery
Shoulder surgery has become a primary intervention for treating persistent shoulder pain, with the number of procedures now exceeding 500,000 annually.26 However, many patients who undergo shoulder surgery experience persistent post-operative pain.3,35 For musculoskeletal pain conditions, current research initiatives aim to identify phenotypical characteristics that predict variability in treatment outcomes.4,12 Our team used exercised-induced shoulder pain to identify an interaction between psychological distress (pain catastrophizing) and genetics (catechol-O-methyltransferase (COMT) enzyme activity) that predicted eleva...
Source: The Journal of Pain - December 28, 2019 Category: Materials Science Authors: Corey B. Simon, Carolina Valencia, Rogelio A. Coronado, Samuel S. Wu, Zhigang Li, Yunfeng Dai, Kevin W. Farmer, Michael M. Moser, Thomas W. Wright, Roger B. Fillingim, Steven Z. George Tags: Original Reports Source Type: research

The promotion of policy changes restricting access to codeine medicines on Twitter: what do national pain organizations say?
Widespread use of opioids has contributed to what has been called an “opioid epidemic”.26,41,49,64,66 Codeine is one of the most commonly used opioid analgesics globally for treating mild to moderate pain.65 In Australia, codeine has remained the dominant opioid medicine that has been dispensed over the past 25 years.24,38,39 It is one of the most widely availabl e opioids, accessible without prescription (over-the-counter; OTC) in a number of countries (e.g., United Kingdom, New Zealand).30,67 (Source: The Journal of Pain)
Source: The Journal of Pain - December 17, 2019 Category: Materials Science Authors: Rachel A. Elphinston, Simone Scotti Requena, Daniel Angus, Dominique de Andrade, Christopher R. Freeman, Melissa A. Day Tags: Original Reports Source Type: research

Improving study conduct and data quality in clinical trials of chronic pain treatments: IMMPACT recommendations
The late stage failure of drug development programs is a significant problem.  Successful phase 2 trial results do not guarantee a successful phase 3 program. The estimated probability of progressing from phase 3 analgesic clinical trials to regulatory approval is approximately 57%, suggesting that a considerable number of treatments with phase 2 trial results deemed suffici ently successful to progress to phase 3 do not yield positive phase 3 results.33 Potential explanations for this high rate of failure in late stage development include (1) false positive phase 2 trial results, (2) incorrect dosage selection based ...
Source: The Journal of Pain - December 13, 2019 Category: Materials Science Authors: Jennifer S. Gewandter, Robert H. Dworkin, Dennis C. Turk, Eric G. Devine, David Hewitt, Mark P. Jensen, Nathaniel P. Katz, Amy A. Kirkwood, Richard Malamut, John D. Markman, Bernard Vrijens, Laurie Burke, James N. Campbell, Daniel B. Carr, Philip G. Conag Source Type: research

Test-retest and inter-examiner reliability of a novel bedside quantitative sensory testing battery in postherpetic neuralgia patients
Quantitative sensory testing (QST) is a well-established method of psychophysical evaluation of the somatosensory system, based on measurements of responses to calibrated, graded innocuous or noxious stimuli2,31,39.It has been used traditionally in the research setting to phenotype patients with a variety of pain disorders39. QST yields valuable information about the functional status of the somatosensory system from peripheral receptor to the cortex, and it may be used to quantify and monitor the presence and severity of either positive sensory phenomena (such as amplified pain perception reported in allodynia or hyperalg...
Source: The Journal of Pain - December 11, 2019 Category: Materials Science Authors: Ajay D. Wasan, Benedict J. Alter, Robert R. Edwards, Charles E. Argoff, Nalini Sehgal, David Walk, Toby Moeller-Bertram, Mark S Wallace, Misha Backonja Tags: Original Reports Source Type: research

Management of patients with a musculoskeletal pain condition that is likely chronic: Results from a national cross sectional survey
Chronic musculoskeletal pain (e.g. back and neck pain, pain due to arthritis, leg pain, arm pain of>3 months duration) affects between 11 and 24% of the general population,5, 10 with some estimates as high as 48% for chronic musculoskeletal complaints.19 Costs attributable to musculoskeletal pain have risen in the United States between 1996 and 2014 from $400 billion to nearly a trillion dollars (i.e. 3.4% of GDP to 5.8% of GDP) and these will no doubt rise even further as the prevalence of musculoskeletal disorders are expected to increase as the population ages. (Source: The Journal of Pain)
Source: The Journal of Pain - December 11, 2019 Category: Materials Science Authors: Debbie Ehrmann Feldman, Lisa C. Carlesso, Richard L. Nahin Tags: Original Reports Source Type: research

Epigenetic and miRNA expression changes in people with pain: a systematic review
Recent scientific evidence demonstrates how most chronic and degenerative disorders are not determined by genetic mutations or polymorphisms, but are rather consequence of complex gene-environment interactions.22,27 Such evidence has been changing our understanding of both common and complex diseases, and an increasing amount of basic science and clinical research has been trying to determine which mechanisms are responsible for linking environmental and lifestyle factors to changes in gene expression. (Source: The Journal of Pain)
Source: The Journal of Pain - December 11, 2019 Category: Materials Science Authors: Andrea Polli, Lode Godderis, Manosij Ghosh, Kelly Ickmans, Jo Nijs Tags: Review Article Source Type: research

The “culture” of pain control: A review of opioid-induced dysbiosis (OID) in antinociceptive tolerance
In October 2017, the United States government declared a state of public health emergency in response to the growing prescription opioid epidemic. Social, political, and medical rhetoric has recently demanded improvements in clinical pain control, prompting the publication of the “Guideline for Prescribing Opioids for Chronic Pain” by the Centers for Disease Control and Prevention (CDC) in March, 2016.31 Over the last decade, opioid use in the US has risen dramatically, with the number of prescriptions written by health care providers in 2012 (∼259 million) exceeding t he total adult population (∼240 mi...
Source: The Journal of Pain - December 10, 2019 Category: Materials Science Authors: Ryan A. Mischel, Karan H. Muchhala, William L. Dewey, Hamid I. Akbarali Tags: Review Article Source Type: research

Masthead
(Source: The Journal of Pain)
Source: The Journal of Pain - December 1, 2019 Category: Materials Science Source Type: research

Editorial Board
(Source: The Journal of Pain)
Source: The Journal of Pain - December 1, 2019 Category: Materials Science Source Type: research

Table of Contents
(Source: The Journal of Pain)
Source: The Journal of Pain - December 1, 2019 Category: Materials Science Source Type: research

Erratum to ‛Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light’
The publisher regrets that the printed version of the above article contained a number of errors. The correct and final version is available at https://doi.org/10.1016/j.jpain.2019.04.008. The publisher would like to apologise for any inconvenience caused. (Source: The Journal of Pain)
Source: The Journal of Pain - December 1, 2019 Category: Materials Science Authors: Rajesh Khanna, Amol Patwardhan, Xiaofang Yang, Wennan Li, Song Cai, Yingshi Ji, Lindsey A. Chew, Angie Dorame, Shreya S. Bellampalli, Ryan W. Schmoll, Janalee Gordon, Aubin Moutal, Todd W. Vanderah, Frank Porreca, Mohab M. Ibrahim Tags: Erratum Source Type: research

Investigation of the Involvement of the Endocannabinoid System in TENS-induced Antinociception
Pain is a complex and subjective symptom that involves quantitative and qualitative factors that directly interfere with public health and incurs an economic cost for its control.39 Pharmacological treatment is currently the most used method for controlling pain; however, it produces many side effects and is highly expensive.43 In this context, nonpharmacological treatments, such as transcutaneous electrical nerve stimulation (TENS), have been increasingly used for the treatment of various types of pain, including cancer pain. (Source: The Journal of Pain)
Source: The Journal of Pain - November 27, 2019 Category: Materials Science Authors: Herick Ulisses de Oliveira, Rafaela Silva dos Santos, Iago Henrique Silva Malta, Jos é Phellipe Pinho, Ana Flávia Santos Almeida, Carlos Arterio Sorgi, Ana Paula Ferranti Peti, Gabriela Santos Xavier, Luciana Maria dos Reis, Lúcia Helena Faccioli, Jade Tags: Original Reports Source Type: research

IFN β treatment inhibits nerve injury-induced mechanical allodynia and MAPK signaling by activating ISG15 in mouse spinal cord
Interferons (IFNs) are a class of cytokines originally detected in immunological cells, but have since been shown to be produced during non-immunological responses of both central and peripheral origins. IFNs regulate antiviral and immunomodulatory responses as well as cell growth in immune cells (lymphocytes and macrophages) and non-immune target cells from epithelial and nervous tissues.10,12,34,61,62 There are two major types of IFNs: type I consists chiefly of IFN α and IFNβ, and also IFNω, IFNδ, and IFNτ, whereas type II consists of a single type, IFNγ. (Source: The Journal of Pain)
Source: The Journal of Pain - November 27, 2019 Category: Materials Science Authors: Su Liu, Stephen Karaganis, Ru-Fan Mo, Xiao-Xiao Li, Ruo-Xin Wen, Xue-Jun Song Tags: Original Reports Source Type: research

Effects of spicy stimulation and spicy-food consumption on human pain sensitivity: A healthy volunteer study
Spice, one of the most popular food additives, has long been used for flavoring, and coloring of food in countries around the world. In China, spicy foods are the most popular nationwide.41 Spicy foods such as chili peppers have antibacterial properties5,26 and can reduce the risk of obesity43,44 and cancer.1,29 Two recent large population-based prospective studies found an inverse relationship between spicy-food consumption and mortality from all causes, cancer, and respiratory and cardiovascular diseases. (Source: The Journal of Pain)
Source: The Journal of Pain - November 26, 2019 Category: Materials Science Authors: Guangyou Duan, Zhuoxi Wu, Zhenxin Duan, Guiying Yang, Liang Fang, Fang Chen, Xiaohang Bao, Hong Li Tags: Original Reports Source Type: research

Investigating the Influence and a Potential Mechanism of Self-compassion on Experimental Pain: Evidence from a Compassionate Self-talk Protocol and Heart Rate Variability
Self-compassion is conceptualized as the ability to be kind and caring toward oneself in times of suffering, failure, or perceived inadequacy.35,36 A number of studies have demonstrated the role of self-compassion in protecting emotional well-being against negative life events.3,4,30-32,52,57 In the field of pain research, increasing evidence has identified a positive association between self-compassion and emotional well-being in people with chronic pain,5,15,20,46,56 while the effects of self-compassion on pain perception are mixed. (Source: The Journal of Pain)
Source: The Journal of Pain - November 21, 2019 Category: Materials Science Authors: Xi Luo, Jianzhao Liu, Xianwei Che Tags: Original Reports Source Type: research

Integrated behavioral treatment for Veterans with co-morbid chronic pain and hazardous opioid use: A randomized controlled pilot trial
Chronic pain, defined as pain that persists longer than three months, is common, costly, and debilitating.10,26,35,50 The preponderance of the available evidence suggests that problems associated with chronic pain have been exacerbated by exponential increases in prescribed opioids over the past few decades.3,4 Overall opioid prescription rates have doubled in this century, from 11% to 20% of all pain-related ambulatory and office-based medical visits, while overall rates of pain as a primary symptom and prescription rates of non-opioid analgesics remained unchanged. (Source: The Journal of Pain)
Source: The Journal of Pain - November 21, 2019 Category: Materials Science Authors: Kevin E. Vowles, Katie Witkiewitz, Karen J. Cusack, Wesley P. Gilliam, Karen E. Cardon, Sarah Bowen, Karlyn A. Edwards, Mindy L. McEntee, Robert W. Bailey Tags: Original Reports Source Type: research

Nociception Coma Scale Revised allows to identify patients with preserved neural basis for pain experience.
The Nociception Coma Scale-Revised (NCS-R) was developed to help assess pain in patients with disorders of consciousness (DOC). Several studies have shown its sensitivity in assessing response to acute noxious stimuli. However, they failed to determine a reliable cut-off score that could be used to infer pain processing in these patients.This retrospective cross-sectional study aimed to determine a NCS-R cut-off score supporting preserved neural basis for pain experience, based on brain metabolism preservation as measured by fluorodeoxyglucose positron emission tomography (FDG-PET). (Source: The Journal of Pain)
Source: The Journal of Pain - November 13, 2019 Category: Materials Science Authors: Estelle A.C. Bonin, Nicolas Lejeune, Aurore Thibaut, Helena Cassol, Georgios Antonopoulos, Sarah Wannez, Charlotte Martial, Caroline Schnakers, Steven Laureys, Camille Chatelle Source Type: research

Sensitivities to Thermal and Mechanical Stimuli:  Adults with Sickle Cell Disease Compared to Healthy, Pain-free African American Controls
Until recent findings that sickle cell disease (SCD) pain has characteristics consistent with central or peripheral sensitization,12,27,28,43 it was typically viewed as acute or persistent pain and treated mostly with opioids. Often the etiology of SCD pain is thought to be only episodic, driven by vaso-occlusion and somatic or visceral tissue damage,1,2,4 however, it has become increasingly clear that adults with SCD also experience chronic pain. A growing body of evidence now supports,12,27,28,40,43, but is not conclusive, that sensitization contributes to chronic pain in some adults with SCD. (Source: The Journal of Pain)
Source: The Journal of Pain - November 13, 2019 Category: Materials Science Authors: Robert E. Molokie, Zaijie J. Wang, Yingwei Yao, Keesha L. Powell-Roach, Judith M. Schlaeger, Marie L. Suarez, David A. Shuey, Veronica Angulo, Jesus Carrasco, Miriam O. Ezenwa, Roger B. Fillingim, Diana J. Wilkie Source Type: research

Sex differences in interleukin-6 responses over time following laboratory pain testing among patients with knee osteoarthritis
Knee osteoarthritis (KOA) is a chronic pain condition that is one of the leading causes of physical impairment and disability across the world.40 The prevalence of KOA is expected to continuously escalate due to population aging and increases in obesity rates.63 Women are particularly at-risk for developing chronic pain and KOA.20,43 Further, women generally report higher pain-related symptoms (including KOA symptoms57), evoked-pain sensitivity, and lower pain tolerance compared to men.20,43 (Source: The Journal of Pain)
Source: The Journal of Pain - November 13, 2019 Category: Materials Science Authors: Chung Jung Mun, Janelle Letzen, Sabrina Nance, Michael T. Smith, Harpal S. Khanuja, Robert S. Sterling, Mark C. Bicket, Jennifer A. Haythornthwaite, Robert N. Jamison, Robert R. Edwards, Claudia M. Campbell Tags: Original Reports Source Type: research

The context of values in pain control: understanding the price effect in placebo analgesia
Placebo effects, a sum of different factors including non-specific effects, regression to the mean, natural history, and placebo responses, substantially contribute to clinical outcomes in diseases such as Parkinson's disease, depression, and immune function, as well as in acute and chronic pain conditions.10,33 Recent studies on placebo effects implicate the importance of informational context relative to medical treatments, most of which have no direct therapeutic effects on the body.42 One distinct feature of every therapeutic intervention is price, or treatment cost. (Source: The Journal of Pain)
Source: The Journal of Pain - November 13, 2019 Category: Materials Science Authors: Ye-Seul Lee, Won-Mo Jung, Ulrike Bingel, Younbyoung Chae Tags: Original Reports Source Type: research

Determining real change in conditioned pain modulation: a repeated measures study in healthy volunteers
Conditioned pain modulation (CPM) is a psychophysical measure thought to be the human correlate of diffuse noxious inhibitory control (DNIC)49, initially identified electrophysiologically in rats22 and suggested as early as 1937 in humans as a phenomenon where ‘pain inhibits pain’.9 It is proposed that pain at one site, the ‘conditioning stimulus’, can modulate (facilitate or inhibit) the experience of pain at a second distant site, the ‘test stimulus’34 via a spino-bulbar-spinal loop.30 (Source: The Journal of Pain)
Source: The Journal of Pain - November 9, 2019 Category: Materials Science Authors: Harriet I. Kemp, Donna L. Kennedy, Chenxian Wu, Deborah A. Ridout, Andrew S.C. Rice Tags: Original Reports Source Type: research

Short- and Long-Term Effects of Cannabis on Headache and Migraine
Use of cannabis to treat headache dates back hundreds to thousands of years,15,23 and is currently widespread among medical cannabis users.2,26 Nearly 36% of medical cannabis users reported using cannabis to treat headache/migraine; moreover, they retrospectively reported an average 3.6-point decrease (on a 10-point scale) in headache severity after cannabis use.26 Similarly, 40% of patients for whom medical cannabis was recommended for migraine reported a positive effect, with a decrease in migraine frequency from 10.4 to 4.6 migraines/month. (Source: The Journal of Pain)
Source: The Journal of Pain - November 9, 2019 Category: Materials Science Authors: Carrie Cuttler, Alexander Spradlin, Michael J. Cleveland, Rebecca M. Craft Source Type: research

Respiratory hypoalgesia? the effect of slow deep breathing on electrocutaneous, thermal, and mechanical pain
Slow deep breathing (SDB) is commonly used as a self-management technique, and a therapeutic tool that often is implemented in relaxation and meditation. In addition, the majority of the existing published clinical and experimental studies on the association of breathing and pain reported promising results (experimental studies: 4/6 or 67%, clinical studies: 6/8 or 75%).27 However, some studies with similar methodologies of those that found a pain dampening effect, did not observe a clear association between breathing and pain. (Source: The Journal of Pain)
Source: The Journal of Pain - November 5, 2019 Category: Materials Science Authors: Imke Courtois, Ali Gholamrezaei, Hassan Jafari, Stefan Lautenbacher, Ilse Van Diest, Lukas Van Oudenhove, Johan W.S. Vlaeyen Tags: Original Reports Source Type: research

The natural course of chronic pain in a general population: Stability and change in an eight-wave longitudinal study over four years (the HUNT pain study)
Estimates of prevalence of chronic pain vary from 9% to 64% in the general population.24,42 One of the most important factors accounting for this substantial variance is inconsistency in the operational definitions used in various studies.42 This problem stems mainly from lack of a clear and standardized definition of chronic pain. The International Association for the Study of Pain (IASP) proposed that pain lasting for longer than three months32,46 and for research purposes, six months, should be the working definition of chronic pain. (Source: The Journal of Pain)
Source: The Journal of Pain - November 5, 2019 Category: Materials Science Authors: Mari Glette, Tore C. Stiles, Petter C. Borchgrevink, Tormod Landmark Tags: Original Reports Source Type: research

Synchronous stimulation with light and heat induces body ownership and reduces pain perception
The rubber hand illusion (RHI), first reported by Botvinick& Cohen,4 is a common method to induce transient changes in body representations: Watching a rubber hand being stroked with a brush while the own unseen hand is stroked in synchrony with the rubber hand induces the feeling that the rubber hand belongs to one's own body. Recently it has been demonstrated that the RHI works best with body parts, but that in principle it is also possible to induce ownership of other types of objects. For example, Ma and Hommel22 showed that a virtual balloon changing in size, and a virtual square changing in size and color, in syn...
Source: The Journal of Pain - November 5, 2019 Category: Materials Science Authors: Larissa Cordier, Xaver Fuchs, Stephan Herpertz, J örg Trojan, Martin Diers Tags: Original Reports Source Type: research

Modified Biofeedback (Conditioned Biofeedback) Promotes Antinociception by Increasing the Nociceptive Flexion Reflex Threshold and Reducing Temporal Summation of Pain: A Controlled Trial
Chronic pain affects 116 million US adults and costs $560 to 635 billion annually in health care utilization and loss of productivity.19,24 Related is the growing problem of prescription painkiller abuse.36 For these reasons, it is important to find safe interventions to prevent and treat pain. Although several effective nonpharmacological pain treatments are available (eg, cognitive and behavioral therapies),10,20,27,45 their effect on pain tends to be small and short-lived.45 Thus, new (or augmented) approaches are needed. (Source: The Journal of Pain)
Source: The Journal of Pain - November 1, 2019 Category: Materials Science Authors: Jamie L. Rhudy, Natalie Hellman, Cassandra A. Sturycz, Tyler A. Toledo, Shreela Palit Tags: Original Reports Source Type: research

Masthead
(Source: The Journal of Pain)
Source: The Journal of Pain - November 1, 2019 Category: Materials Science Source Type: research

Editorial Board
(Source: The Journal of Pain)
Source: The Journal of Pain - November 1, 2019 Category: Materials Science Source Type: research

Table of Contents
(Source: The Journal of Pain)
Source: The Journal of Pain - November 1, 2019 Category: Materials Science Source Type: research

The Pediatric American Pain Society Patient Outcomes Questionnaire (Pediatric APS-POQ): Development and Initial Psychometric Evaluation of a Brief and Comprehensive Measure of Pain and Pain Outcomes in Hospitalized Youth
(Source: The Journal of Pain)
Source: The Journal of Pain - November 1, 2019 Category: Materials Science Authors: Karen Kaczynski, Elizabeth Ely, Debra Gordon, Catherine Vincent, Kristi Waddell, Kimberly Wittmayer, Esther Bernhofer Tags: Original Reports Source Type: research

A Comparative Meta-Analysis of Unidisciplinary Psychology and Interdisciplinary Treatment Outcomes Following Acceptance and Commitment Therapy for Adults with Chronic Pain
Psychological interventions for chronic pain have a longstanding history of empirical support.26 Support for psychological approaches can be found in both systematic reviews18,29,33 and meta-analyses.22,45 Two successive meta-analyses sponsored by the Cochrane Collaboration have, however, indicated that randomized controlled trials (RCTs) of psychological approaches for chronic pain have only small to moderate benefits, especially at follow-up.13,57 Thus, there is an inconsistency in the literature, where one conclusion from the extant research is that psychological approaches for chronic pain work reasonably well while so...
Source: The Journal of Pain - November 1, 2019 Category: Materials Science Authors: Kevin E. Vowles, Melissa Pielech, Karlyn A. Edwards, Mindy L. McEntee, Robert W. Bailey Source Type: research

Efficacy of Interpretation Bias Modification in Patients with Chronic Pain
Attentional bias is one of the most studied information-processing biases in chronic pain research.14,22,42,52,55,57 However, recent meta-studies of attentional bias showed that the effect size of attentional bias to pain words was small for patients with chronic pain (Cohen's d  = .14) and provided no support for an association between attentional bias and theoretically important constructs, such as pain intensity and anxiety.11,66 These results may explain the inconsistent result of attention bias modification (ABM) which trains participants to focus their attention a way from pain words. (Source: The Journal of Pain)
Source: The Journal of Pain - November 1, 2019 Category: Materials Science Authors: Jeongwi An, Kyeong-seok Wang, Youn-hee Jung, Sungkun Cho Source Type: research

Modified biofeedback (Conditioned Biofeedback) promotes anti-nociception by increasing the nociceptive flexion reflex threshold and reducing temporal summation of pain: A controlled trial
Chronic pain affects 116 million U.S. adults and costs $560-635 billion annually in health care utilization and loss of productivity.20,25 Related is the growing problem of prescription painkiller abuse.37 For these reasons, it is important to find safe interventions to prevent and treat pain. Although several effective non-pharmacological pain treatments are available (e.g., cognitive and behavioral therapies),9,11,21,28 their effect on pain tends to be small and short-lived.9 Thus, new (or augmented) approaches are needed. (Source: The Journal of Pain)
Source: The Journal of Pain - November 1, 2019 Category: Materials Science Authors: Jamie L. Rhudy, Natalie Hellman, Cassandra A. Sturycz, Tyler A. Toledo, Shreela Palit Tags: Original Reports Source Type: research

Shared sensitivity to physical pain and social evaluation
While physical pain is perceptually distinct from emotional experiences that accompany social distress (e.g., rejection or exclusion), both states involve suffering and activate overlapping neuronal circuitry.12,13 For example, in one study, volunteers who recently experienced an unwanted breakup in a romantic relationship were recruited, and their brain activity to viewing photographs of their ex-partners as they thought about being rejected (social rejection) and to nociceptive somatosensory stimulation (physical pain) was recorded. (Source: The Journal of Pain)
Source: The Journal of Pain - November 1, 2019 Category: Materials Science Authors: Manlin Yao, Yi Lei, Peng Li, Qian Ye, Yang Liu, Xiaoyun Li, Weiwei Peng Source Type: research

Erratum
In the article “Cost-Effectiveness and Cost-Utility of Internet-Delivered Exposure Therapy for Fibromyalgia: Results From A Randomized, Controlled Trial,” published in the January 2019 issue of The Journal of Pain (2019; 20:47-59), the median value for direct medical costs for iExp at post-treatment was incorr ectly displayed in Table 2. The correct table appears below. (Source: The Journal of Pain)
Source: The Journal of Pain - October 29, 2019 Category: Materials Science Tags: Erratum Source Type: research