Desire to receive more pain treatment – a relevant patient-reported outcome measure to assess quality of post-operative pain management? Results from 79,996 patients enrolled in the pain registry QUIPS from 2016 to 2019.
Pain after surgery is still a major issue in healthcare.3, 16 Although there are efforts to objectify it.7 pain is still routinely assessed by asking patients to rate their subjective pain intensity on various scales, e.g., the numeric rating scale, the visual analog scale, different faces pain scales, and others.20 Often, pain treatment is then based on or at least influenced by these ratings. (Source: The Journal of Pain)
Source: The Journal of Pain - January 19, 2021 Category: Materials Science Authors: Marcus Komann, Philipp Baumbach, Ulrike M. Stamer, Claudia Weinmann, Christin Arnold, Esther Pogatzki-Zahn, Winfried Mei ßner Source Type: research

A better touch: C-tactile fibres related activity is associated to pain reduction during temporal summation of second pain
This study extends previous findings on the analgesic potential of affective touch, documenting a clear pain reduction during temporal summation of second pain (TSSP). Since TSSP is thought to reflect central sensitization, the psychophysiological mechanisms of affective touch could be exploited for new chronic pain treatments. (Source: The Journal of Pain)
Source: The Journal of Pain - January 16, 2021 Category: Materials Science Authors: Fabrizia Fidanza, Elisa Polimeni, Valentina Pierangeli, Matteo Martini Source Type: research

Exposure to an immersive virtual reality environment modulate perceptual correlates of endogenous analgesia and central sensitisation in healthy volunteers
Exposure to immersive 360 ° virtual reality (VR) environments has been shown to produce analgesic effects during acute medical procedures as well as in human surrogate pain models and chronic pain states 12, 21, 30, 31. Growing evidence suggests that cognitive and attentional factors are known to have an influence on spinal cord representations of central sensitisation as well as endogenous analgesic circuitry implicated in the descending control of pain 10, 45. However, there is a lack of research into whether the pain-relieving effects of an immersive VR experience are due to top-down influences on perceptual correl ...
Source: The Journal of Pain - January 16, 2021 Category: Materials Science Authors: Mehesz Erzsebet, Hajer Karoui, Paul H Strutton, Sam W Hughes Source Type: research

Serotonin plays a key role in the development of opioid-induced hyperalgesia in mice
Opioids are essential for the management of perioperative pain as well as palliative treatment of cancer pain. However, chronic administering of opioids may cause a reduction in the analgesic effect (tolerance), and lead to paradoxical hyperalgesia (opioid-induced hyperalgesia (OIH)) and subsequent physical dependency.2,24,47 More specifically, OIH is often associated with a requirement for increased, and often long-term, administering of opioids, which worsen tolerance, resulting in physical and mental dependence. (Source: The Journal of Pain)
Source: The Journal of Pain - January 16, 2021 Category: Materials Science Authors: Mika Sasaki, Yoshinori Kamiya, Keiko Bamba, Takeshi Onishi, Keiichiro Matsuda, Tatsuro Kohno, Miyuki Kurabe, Kenta Furutani, Harue Yanagimura Tags: Original Reports Source Type: research

A Systematic Review and Meta-Analysis of the Association between Perceived Injustice and Depression
The past decade has witnessed a dramatic increase in research concerning the identification, development and validation of a psychosocial construct referred to as perceived injustice. While contributions to injustice from an organisational and psychological perspective date back to the 1960 ’s with the development of Equity Theory1 and include various interpretations and definitions of procedural, distributive, informational and interpersonal injustice in workplace settings,14,22 efforts to consider injustice from a clinical health perspective have been comparatively recent. (Source: The Journal of Pain)
Source: The Journal of Pain - January 16, 2021 Category: Materials Science Authors: Julie Lynch, Susan Fox, Dr Paul D'Alton, Keith Gaynor Tags: Review Article Source Type: research

A role for protease activated receptor type 3 (PAR3) in nociception demonstrated through development of a novel peptide agonist
Protease activated receptor 3 (PAR3) belongs to the PAR family of G-protein coupled receptors (GPCRs), a group of receptors expressed in many cell types and implicated in a variety of inflammatory pathologies 11, 26, 28, 56. Like the other PARs, PAR3 does not have an endogenously present ligand but rather is activated through extracellular cleavage of the N-terminal end via proteases. After proteolytic cleavage, the newly available tethered ligand can bind to the receptor, initiating multiple downstream signaling cascades 51. (Source: The Journal of Pain)
Source: The Journal of Pain - January 8, 2021 Category: Materials Science Authors: Juliet Mwirigi, Moeno Kume, Shayne N Hassler, Ayesha Ahmad, Pradipta R Ray, Changyu Jiang, Alexander Chamessian, Nakleh Mseeh, Breya P Ludwig, Benjamin D. Rivera, Marvin T Nieman, Thomas Van de Ven, Ru-Rong Ji, Gregory Dussor, Scott Boitano, Josef Vagner, Source Type: research

Primary sensorimotor cortex is modified by a 6 week graded motor imagery training in chronic CRPS patients: a randomized trial
Complex regional pain syndrome (CRPS) shows severe painful symptoms of the affected body part (for a concise description of symptoms and pathophysiology see 6) and has an incidence rate of approximately 26 per 100,000 person years33. Because of its high rate of chronification, powerful treatment options are needed. Longitudinal intervention studies with neurophysiological and imaging control can help to understand treatment gain and underlying brain changes. (Source: The Journal of Pain)
Source: The Journal of Pain - January 6, 2021 Category: Materials Science Authors: S. Strauss, S. Barby, J. H ärtner, N. Neumann, G.L. Moseley, M. Lotze Tags: Original Reports Source Type: research

Central endothelin-1 confers analgesia by triggering spinal neuronal histone deacetylase 5 (HDAC5) nuclear exclusion in peripheral neuropathic pain in mice
In this study, we aimed to investigate whether central ET-1 plays an anti-nociceptive role by facilitating spinal HDAC5 nuclear shuttling under neuropathic pain. Here, we demonstrate that upregulating spinal ET-1 attenuated the nociception induced by partial sciatic nerve ligation (pSNL) surgery and this analgesic effect mediated by ET-1 was attenuated by intrathecal injection of endothelin A receptor (ETAR) selective inhibitor (BQ123) or by blocking the exportation of nuclear HDAC5 by adeno-associated viruses targeting neuronal HDAC5 (AVV-HDAC5 S259/498A Mutant). (Source: The Journal of Pain)
Source: The Journal of Pain - January 6, 2021 Category: Materials Science Authors: Pan Gu, Tingting Fan, Stanley Sau Ching Wong, Zhiqiang Pan, Wai Lydia Tai, Sookja Kim Chung, Chi Wai Cheung Tags: Original Reports Source Type: research

A Systematic Review into the Influence of Temperature on Fibromyalgia Pain: Meteorological Studies and Quantitative Sensory Testing
Fibromyalgia syndrome (FMS) is a chronic widespread pain condition of uncertain aetiology and may be viewed as pain state with central amplification13, 14, 74. However, there is also mounting evidence of peripheral abnormalities including small fibre polyneuropathy with abnormal nociceptor function25, 33, 51, 73, abnormal thermoregulatory peripheral innervations1, and even peripherally binding pain-sensitising IgG autoantibodies31. FMS is characterised by widespread pain and a constellation of other symptoms, most markedly fatigue, sleep disturbance and cognitive problems14, 90. (Source: The Journal of Pain)
Source: The Journal of Pain - January 6, 2021 Category: Materials Science Authors: Richard J. Berwick, Sara Siew, David A. Andersson, Andrew Marshall, Andreas Goebel Source Type: research

Cannabidiol Use for Fibromyalgia: Prevalence of Use and Perceptions of Effectiveness in a Large Online Survey
Fibromyalgia (FM) is a common chronic pain condition, affecting 2-4% of the population.2,16 FM is characterized by widespread pain and is often accompanied by a cluster of co-occurring symptoms, including sleep problems, depression, cognitive dysfunction (i.e., fibro-fog), and fatigue.16 While FM is best managed with a combination of pharmacological and non-pharmacological interventions (e.g., exercise, self-management skills, acupuncture),16 many non-pharmacological interventions remain poorly covered by insurance,5 leaving people with FM to rely mainly on insurance-covered medications. (Source: The Journal of Pain)
Source: The Journal of Pain - January 2, 2021 Category: Materials Science Authors: Kevin F. Boehnke, Joel J. Gagnier, Lynne Matallana, David A. Williams Tags: Original Reports Source Type: research

Sensory and psychological factors predict exercise-induced shoulder injury responses in a high-risk phenotype cohort
The pain experience is a highly individualized and variable experience.11,12,27 Precision medicine is a promising approach to addressing the individual variability inherent to the pain experience by offering effective tailored treatment options.11,12,42 Pain phenotyping is strongly recommended to advance pain-specific precision medicine approaches, as there are greater inter-individual differences across pain-related factors than mechanistic differences across pain conditions.11 For instance, assessments of pain-related factors (e.g. (Source: The Journal of Pain)
Source: The Journal of Pain - January 2, 2021 Category: Materials Science Authors: Katie A. Butera, Mark D. Bishop, Warren H. Greenfield, Roland Staud, Margaret R. Wallace, Paul A. Borsa, Roger B. Fillingim, Steven Z. George Tags: Original Reports Source Type: research

Masthead
(Source: The Journal of Pain)
Source: The Journal of Pain - December 24, 2020 Category: Materials Science Source Type: research

Editorial Board
(Source: The Journal of Pain)
Source: The Journal of Pain - December 24, 2020 Category: Materials Science Source Type: research

Table of Contents
(Source: The Journal of Pain)
Source: The Journal of Pain - December 24, 2020 Category: Materials Science Source Type: research

Increased salience network connectivity following manual therapy is associated with reduced pain in chronic low back pain patients
Chronic low back pain (cLBP) has been associated with changes in brain plasticity. Non-pharmacological therapies such as Manual Therapy (MT) have shown promise for relieving cLBP. However, translational neuroimaging research is needed to understand potential central mechanisms supporting MT. We investigated the effect of MT on resting-state salience network (SLN) connectivity, and whether this was associated with changes in clinical pain.Fifteen cLBP patients, and 16 matched healthy controls (HC) were scanned with resting functional Magnetic Resonance Imaging (fMRI), before and immediately after a MT intervention (cross-ov...
Source: The Journal of Pain - December 11, 2020 Category: Materials Science Authors: Kylie Isenburg, Ishtiaq Mawla, Marco L. Loggia, Dan-Mikael Ellingsen, Ekaterina Protsenko, Matthew H. Kowalski, David Swensen, Deanna O'Dwyer-Swensen, Robert R. Edwards, Vitaly Napadow, Norman Kettner Tags: Original Reports Source Type: research

Transcutaneous Electric Nerve Stimulation reduces acute postoperative pain and analgesic use after open inguinal hernia surgery: a randomized, double-blind, placebo-controlled trial
Worldwide, more than 20 million patients undergo inguinal hernia repair annually.25 Open tensionless repair techniques will be an important treatment for the foreseeable future.32 Lichtenstein repair is widely considered the “gold standard” in open tensionless inguinal hernia repair. Since the introduction of meshes, recurrence rates have decreased, with a current occurrence rate 1-2%, and great attention has been directed to postoperative acute and chronic pain treatment.22 Acute pain is the most common complaint r eported by patients following inguinal hernia repair. (Source: The Journal of Pain)
Source: The Journal of Pain - December 10, 2020 Category: Materials Science Authors: Audrius Parseliunas, Saulius Paskauskas, Egle Kubiliute, Jovydas Vaitekunas, Donatas Venskutonis Tags: Original Reports Source Type: research

Cross-sectional study of prevalence, characterization and impact of chronic pain disorders in workers
The risks of developing a chronic disease increase when the psychosocial environment is unfavorable and repetitive physical efforts are added, for example, through handling work and static postures14,33. An unfavorable psychosocial environment corresponds to working conditions that may lead to psychosocial risks, for example: overwork and stress; conflicting requirements and lack of clarity about the missions to be performed; insufficient involvement of workers in decisions affecting them and their careers; insufficient management of job changes and job insecurity; insufficient communication and support from management or ...
Source: The Journal of Pain - December 9, 2020 Category: Materials Science Authors: N. Kerckhove, C. Lambert, A. Corteval, B. Pereira, A. Eschalier, C. Dual é Tags: Original Reports Source Type: research

Optimization of spinal manipulative therapy protocols: a factorial randomized trial within a multiphase optimization framework
Low back pain (LBP) is among the most common health conditions and a leading cause of disability globally.1, 38 The adverse societal impacts of ineffective LBP management are increasingly recognized. Back pain is the most costly health condition in the United States and is the most common diagnosis for which opioids are prescribed.22, 70 Practice guidelines recommend nonpharmacological treatment (NPT) for pain conditions including LBP.18, 23, 58 While many NPTs are effective for LBP, the magnitude of effects are small and highly heterogeneous within groups of patients. (Source: The Journal of Pain)
Source: The Journal of Pain - December 9, 2020 Category: Materials Science Authors: Julie M. Fritz, Jason Sharpe, Tom Greene, Elizabeth Lane, Maliheh Hadizadeh, Molly McFadden, Douglas Santillo, Jedidiah Farley, Jake Magel, Anne Thackeray, Gregory Kawchuk Tags: Original Reports Source Type: research

Transcranial direct current stimulation of the dorsolateral prefrontal cortex alters emotional modulation of spinal nociception
Emotion has a strong modulatory effect on pain perception and the nociceptive system 8,42,43. In healthy individuals, experience of unpleasant emotions facilitates pain, whereas experience of pleasant emotions inhibits pain 43. Dysregulation of this system has been identified in clinical populations and has been theorized as a mechanism underlying development and maintenance of chronic pain 8,12,17,38,49. However, experimental evidence for the neural mechanisms involved in these processes is limited 46. (Source: The Journal of Pain)
Source: The Journal of Pain - November 27, 2020 Category: Materials Science Authors: P. Maxwell Slepian, Christopher R. France, Jamie L. Rhudy, Brian C. Clark Tags: Original Reports Source Type: research

Involvement of TACAN, a mechanotransducing ion channel, in inflammatory but not neuropathic hyperalgesia in the rat
Most clinical pain syndromes are associated with sensitization of nociceptors to mechanical stimuli, especially those pain syndromes associated with inflammation 33,42,44,46,54 and peripheral neuropathy 12,22,31,53. Mechanotransduction in sensory neurons is a vital process underlying several physiological functions, including hearing, touch, pain, and proprioception 14,18,41,61. The mechanisms underlying mechanotransduction in somatosensory neurons have only recently begun to be elucidated. Piezo2, a mechanotransducing ion channel is now well-established to contribute to the sensation of light touch 34,62, and may also con...
Source: The Journal of Pain - November 20, 2020 Category: Materials Science Authors: Ivan J.M. Bonet, Dion éia Araldi, Oliver Bogen, Jon D. Levine Tags: Original Reports Source Type: research

Longitudinal transcriptomic profiling in carrageenan-induced rat hind paw peripheral inflammation and hyperalgesia reveals progressive recruitment of innate immune system components.
Pain is a common yet complex and potentially debilitating symptom that can negatively influence the quality of life for patients with acute and chronic medical conditions.56 In the United States, approximately 100 million adults are affected by chronic pain at a total medical cost of approximately $600 billion in 2010.13 Providing appropriate pain management with accurate pain assessment in the early phases of tissue injury is essential. However, difficulties in accurately assessing pain can be encountered due to complexities associated with the etiology of the original insult and the neural mechanisms of nociception that ...
Source: The Journal of Pain - November 20, 2020 Category: Materials Science Authors: Taichi Goto, Matthew R. Sapio, Dragan Maric, Jeffrey M. Robinson, Leorey N. Saligan, Andrew J. Mannes, Michael J. Iadarola Source Type: research

A cost-effectiveness analysis of an internet-delivered pain management program delivered with different levels of clinician support: Results from a randomised controlled trial.
Chronic pain significantly affects the lives of approximately 1 in 20 adults37 and is associated with increased risk of mental health difficulties, such as anxiety and depression30,32. The economic costs of chronic pain are also significant in terms of both lost workforce participation and ongoing health care use2,39. Reflecting this, in 2012, chronic pain was estimated to cost up to $635 billion every year in the United States18. (Source: The Journal of Pain)
Source: The Journal of Pain - November 20, 2020 Category: Materials Science Authors: Blake F Dear, Eyal Karin, Rhiannon Fogliati, Joanne Dudeney, Olav Nielssen, Amelia J Scott, Milena Gandy, Madelyne A Bisby, Andreea I Heriseanu, Taylor Hathway, Lauren Staples, Nickolai Titov, Liz Schroeder Source Type: research

Analgesic Effects of Topical Amitriptyline in Patients with Chemotherapy-Induced Peripheral Neuropathy: Mechanistic Insights from Studies in Mice
Antidepressants are an essential component of the therapeutic strategy for treatment of many causes of persistent pain 15, 49. Tricyclic antidepressants (TCAs) are the recommended first-line treatment for many forms of persistent neuropathic pain 11, 15, 22. Amitriptyline hydrochloride (amitriptyline), a TCA approved for the treatment of major depression, has been shown to be effective for the treatment of pain associated with a range of neuropathic pain conditions, including diabetic neuropathy, fibromyalgia and postherpetic neuralgia 19, 25, 27. (Source: The Journal of Pain)
Source: The Journal of Pain - November 19, 2020 Category: Materials Science Authors: Anne-Laure Genevois, J érôme Ruel, Virginie Penalba, Séverine Hatton, Camille Petitfils, Myriam Ducrocq, Paola Principe, Gilles Dietrich, Céline Greco, Patrick Delmas Tags: Original Reports Source Type: research

Assessment of Chronic Pain Management in the Treatment of Opioid Use Disorder: Gaps in Care and Implications for Treatment Outcomes
Chronic pain (i.e., pain experienced for 3 months or longer) is a significant comorbid condition among individuals with opioid use disorder (OUD).3,17 Despite this well-documented complexity, there are conflicting perceptions of who is responsible for addressing chronic pain within OUD, with prior literature referencing the assessment and management of chronic pain within a general term of “physicians” or across multiple physician specialties such as addiction medicine, pain specialists, or primary care physicians. (Source: The Journal of Pain)
Source: The Journal of Pain - November 13, 2020 Category: Materials Science Authors: Mathew S. Ellis, Zachary Kasper, Theodore Cicero Tags: Original Reports Source Type: research

Does Threat Enlarge Nociceptive Reflex Receptive Fields?
Pain modulation can increase survival. For example, during situations of possible threat, increased pain perception allows for early detection, and stronger reaction to, somatic danger 45, 52. Consistent with this, several studies have noted an increase in pain perception when anticipating an unpredictable threat 30, 76, 79. (Source: The Journal of Pain)
Source: The Journal of Pain - November 6, 2020 Category: Materials Science Authors: Edward W. Lannon, Fabricio A. Jure, Ole K æseler Andersen, Jamie L. Rhudy Source Type: research

Erratum to ʻLate Breaking Abstractsʼ
[The Journal of Pain 4 (2019) S55 –S74/3714] (Source: The Journal of Pain)
Source: The Journal of Pain - November 1, 2020 Category: Materials Science Authors: L. Friedman, M. Martel Tags: Erratum Source Type: research

Masthead
(Source: The Journal of Pain)
Source: The Journal of Pain - November 1, 2020 Category: Materials Science Source Type: research

Editorial Board
(Source: The Journal of Pain)
Source: The Journal of Pain - November 1, 2020 Category: Materials Science Source Type: research

Table of Contents
(Source: The Journal of Pain)
Source: The Journal of Pain - November 1, 2020 Category: Materials Science Source Type: research

Prior pain exposure and mere possession of a placebo analgesic predict placebo analgesia: Findings from a randomised, double-blinded, controlled trial
Placebo effects occur when an inert substance/treatment procedure induces beneficial psychological/physical change60,90. A significant amount of research investigating the placebo effect is in the realm of pain and analgesia. These researches provided evidence of placebo analgesic response18,75,97, and the magnitude of placebo analgesia varied across studies19,94,96. Researchers had identified several key variables that modulate the placebo responses. For example, researchers have surmised that positive expectancies, introduced through various strategies such as verbal suggestion4,78,96, conditioning67,80 and social observ...
Source: The Journal of Pain - October 27, 2020 Category: Materials Science Authors: Victoria Wai-lan Yeung, Andrew L Geers Tags: Original Reports Source Type: research

II. Indices of pain intensity derived from ecological momentary assessments and their relationships with patient functioning: an individual patient data meta-analysis
Pain intensity is one of the core outcome measures in chronic pain research and practice. Even though the label “chronic pain” carries a notion of constancy, pain experiences in everyday life are not static, but rather dynamically changing within days and across days, even in patients with chronic pain9,31,52. Often the primary outcome variable in clinical settings has been the average of an individual's pain intensity over a specified period of time (e.g., the average pain over the course of one week). (Source: The Journal of Pain)
Source: The Journal of Pain - October 23, 2020 Category: Materials Science Authors: Stefan Schneider, Doerte U. Junghaenel, Joan E. Broderick, Masakatsu Ono, Marcella May, Arthur A. Stone Tags: Original Reports Source Type: research

III. Detecting treatment effects in clinical trials with different indices of pain intensity derived from ecological momentary assessment
Pain intensity is the primary outcome in most clinical trials of pain disorders.14 Although a substantial body of research has been devoted to determining reliable and valid methods of self-reported pain assessment,25 an important question is whether and how the information obtained from pain intensity measures could be improved to enhance detection of treatment effects.23,24,47,48,53 The overall amount of pain (typically conceptualized as the average pain level over a day or week) has served as the most common pain intensity outcome in many clinical trials. (Source: The Journal of Pain)
Source: The Journal of Pain - October 23, 2020 Category: Materials Science Authors: Stefan Schneider, Doerte U. Junghaenel, Masakatsu Ono, Joan E. Broderick, Arthur A. Stone Tags: Original Reports Source Type: research

Investigating the true effect of psychological variables measured prior to arthroplastic surgery on post-surgical outcomes: a p-curve analysis
Osteoarthritis (OA) is a chronic pain condition that affects roughly 8.75 million people in the UK, with the knee and hip being the most commonly affected sites 2. Although arthroplasty is considered an effective treatment and, in many cases, a cure for chronic OA-pain, almost 30% of patients undergoing knee or hip replacement surgery develop increased pain and disability, despite objective indicators of surgical success 7,17,51. Patients ’ pre-surgical psychological profiles may play a major role in determining the long-term efficacy of surgery by affecting the recovery process 13,32,40,45,59,60,68,78–80. (Sou...
Source: The Journal of Pain - October 20, 2020 Category: Materials Science Authors: Nils Georg Niederstrasser, Stephanie Cook Tags: Review Article Source Type: research

Median Nerve Stimulation as a Nonpharmacological Approach to Bypass Analgesic Tolerance to Morphine: A Proof-of-Concept Study in Mice
Opioids are commonly prescribed for postoperative pain77 or severe neuropathic pain.75 However, many patients continue to consume opioids well after surgery21 due to continued pain18 or postsurgical opioid over-prescription.5,40 Analgesic tolerance developing after repeated opioid consumption7 further increases the risk of developing opioid dependence, withdrawal and/or overdose.38,68 Therefore, unresolved severe chronic pain or opioid over-prescription may lead to opioid use disorder,22,23 contributing to the ongoing opioid crisis. (Source: The Journal of Pain)
Source: The Journal of Pain - October 15, 2020 Category: Materials Science Authors: Ming Tatt Lee, Yi-Hung Chen, Ken Mackie, Lih-Chu Chiou Tags: Original Reports Source Type: research

Pain Intensity as a Lagging Indicator of Patient Improvement: Longitudinal Relationships with Sleep, Psychiatric Distress, and Function in Multidisciplinary Care
Traditional biomedical treatment models for chronic pain have conceptualized pain intensity as the primary target for intervention based on the belief that pain arises primarily from a specific medical pathology that must be addressed as a first step before co-occurring problems such as insomnia, depression and functional impairment may improve. That reduction of pain intensity must precede improvement in these other problems is a common belief for both clinicians13 and patients.2, 6, 24, 27 However, there is robust evidence that pain reduction may be accompanied or even preceded by changes in sleep disturbance, function, ...
Source: The Journal of Pain - October 15, 2020 Category: Materials Science Authors: John A. Sturgeon, Dale Langford, David Tauben, Mark Sullivan Tags: Original Reports Source Type: research

Median nerve stimulation as a non-pharmacological approach to bypass analgesic tolerance to morphine: a proof-of-concept study in mice
Opioids are commonly prescribed for postoperative pain77 or severe neuropathic pain.75 However, many patients continue to consume opioids well after surgery21 due to continued pain18 or postsurgical opioid over-prescription.5, 40 Analgesic tolerance developing after repeated opioid consumption7 further increases the risk of developing opioid dependence, withdrawal and/or overdose.38, 68 Therefore, unresolved severe chronic pain or opioid over-prescription may lead to opioid use disorder,22, 23 contributing to the ongoing opioid crisis. (Source: The Journal of Pain)
Source: The Journal of Pain - October 15, 2020 Category: Materials Science Authors: Ming Tatt Lee, Yi-Hung Chen, Ken Mackie, Lih-Chu Chiou Source Type: research

Molecular pathways linking oxylipins to nociception in rats
The question of how pain begins must involve generation of biochemical mediators that interface with the nerve terminals of nociceptive sensory neurons. A corollary of this hypothesis is that the necessary molecular apparatus for generating such algogenic mediators is present or can be induced in tissue in response to damage or pathological conditions. Framed by the view that tissue damage involves membrane damage, the present investigation examines these questions from the perspective of bioactive lipids. (Source: The Journal of Pain)
Source: The Journal of Pain - October 4, 2020 Category: Materials Science Authors: Anthony F. Domenichiello, Matthew R. Sapio, Amelia J. Loydpierson, Dragan Maric, Taichi Goto, Mark S. Horowitz, Gregory S. Keyes, Zhi-Xin Yuan, Sharon. F. Majchrzak-Hong, Andrew J. Mannes, Michael J. Iadarola, Christopher E. Ramsden Tags: Original Reports Source Type: research

Chronic opioid therapy: a scoping literature review on evolving clinical and scientific definitions
Chronic opioid therapies (COT) are widely prescribed for the treatment of chronic pain related to palliative care, active cancer, and end-of-life care.43, 189 However, the use of COT to alleviate and manage chronic non-cancer pain (CNCP) remains controversial due to the risk for development of opioid use disorder, overdose, and opioid-related deaths.43 Despite the increased use of opioids to manage a wide range of chronic pain conditions, there is limited data regarding the effectiveness of long-term opioid treatment for CNCP particularly when considering COT as a primary treatment option. (Source: The Journal of Pain)
Source: The Journal of Pain - October 4, 2020 Category: Materials Science Authors: Yun Shen, Hemita Bhagwandass, Tychell Branchcomb, Sophia A. Galvez, Ivanna Grande, Julia Lessing, Mikela Mollanazar, Natalie Ourhaan, Razanne Oueini, Michael Sasser, Ivelisse L. Valdes, Ashmita Jadubans, Josef Hollmann, Michael Maguire, Silken Usmani, Sco Tags: Review Article Source Type: research

I. Indices of Pain Intensity derived from Ecological Momentary Assessments: Rationale and Stakeholder Preferences
Pain assessment that fully represents patients ’ experiences with pain is essential for chronic pain research and management. Self-reports of pain intensity represent the primary outcome in most pain clinical trials and are nearly universally assessed during patient encounters15,28,46. However, it is widely acknowledged that current pain measu rement can and should be improved22,46. There are various aspects of pain that can provide information of diagnostic importance and that can reflect change due to treatment. (Source: The Journal of Pain)
Source: The Journal of Pain - September 13, 2020 Category: Materials Science Authors: Arthur A. Stone, Joan E. Broderick, Roberta E. Goldman, Doerte U. Junghaenel, Alicia Bolton, Marcella May, Stefan Schneider Tags: Original Reports Source Type: research

Transcranial direct current stimulation accelerates the onset of exercise-induced hypoalgesia: a randomised controlled study
Exercise-induced hypoalgesia (EIH) describes a transient reduction in pain intensity and sensitivity that follows a single bout of exercise.40 This hypoalgesic response is one mechanism thought to underpin the success of exercise as a conservative treatment for musculoskeletal pain.71 Indeed, there is some evidence demonstrating that short-term pain relief following exercise increases confidence and adherence to regular activity.41,54,74 However, accumulating evidence suggests that a single bout of exercise produces weak or inconsistent effects on pain sensitivity in patients with persistent pain. (Source: The Journal of Pain)
Source: The Journal of Pain - September 10, 2020 Category: Materials Science Authors: Jana Borovskis, Rocco Cavaleri, Felicity Blackstock, Simon J Summers Tags: Original Reports Source Type: research

Altered brainstem pain modulating circuitry functional connectivity in chronic painful Temporomandibular Disorder
It is well established from preclinical studies that the brainstem contains multiple circuits that can modulate incoming nociceptive information. For example, regions such as the midbrain periaqueductal  gray (PAG), the rostral ventromedial medulla (RVM), the locus coeruleus (LC), and the subnucleus reticularis dorsalis (SRD) can directly and indirectly inhibit and facilitate activity at the primary nociceptive synapse and thus influence nociceptive transmission to higher brain areas.5,7,22,35, 47 Spontaneous activity within this network, particularly within the RVM, is dynamic and can fluctuate between...
Source: The Journal of Pain - September 2, 2020 Category: Materials Science Authors: Emily P. Mills, Rahena Akhter, Flavia Di Pietro, Greg M Murray, Chris C Peck, Paul M. Macey, Luke A. Henderson Tags: Original Reports Source Type: research

Masthead
(Source: The Journal of Pain)
Source: The Journal of Pain - September 1, 2020 Category: Materials Science Source Type: research

Editorial Board
(Source: The Journal of Pain)
Source: The Journal of Pain - September 1, 2020 Category: Materials Science Source Type: research

Table of Contents
(Source: The Journal of Pain)
Source: The Journal of Pain - September 1, 2020 Category: Materials Science Source Type: research

Chronic Pain and Premature Aging – The Moderating Role of Physical Exercise
Chronic pain induces a multitude of harmful effects; recently it has been suggested that chronic pain is also associated with premature aging, manifested in shortened telomere length (TL). However, evidence for this hypothesis is scarce and inconsistent. The aim was twofold: 1) Investigate whether chronic pain is associated with premature aging, and 2) Determine whether physical exercise (PE) moderates this association if it exists. Participants were 116 male subjects, with (n=67) and without chronic pain (n=49). (Source: The Journal of Pain)
Source: The Journal of Pain - August 12, 2020 Category: Materials Science Authors: Yael Lahav, David Levy, Avi Ohry, Gabi Zeilig, Meir Lahav, Hava Golander, Anat-Chacham Guber, Orit Uziel, Ruth Defrin Tags: Original Reports Source Type: research

The Time Course of Facial Expression Recognition Using Spatial Frequency Information: Comparing Pain and Core Emotions
Accurately detecting and interpreting nonverbal expressions of pain is important for caregiving. Although not conceptualised as an emotion, pain can also be communicated through facial expressions 19,32,38. The main method used to explore this takes a component approach, measuring movements of facial muscles during pain 12. However, this may be different to how we process facial expressions in naturalistic environments, where challenging visual conditions mean that specific details are difficult to see, e.g., brief exposure, limited visibility 10,34,43,44. (Source: The Journal of Pain)
Source: The Journal of Pain - August 5, 2020 Category: Materials Science Authors: Shan Wang, Christopher Eccleston, Edmund Keogh Tags: Original Reports Source Type: research

Injectable PLGA-coated ropivacaine produces a long-lasting analgesic effect on incisional pain and neuropathic pain
Despite great efforts in research on the control of persistent postsurgical pain during past decades, management of this disorder remains a challenge in a large number of patients59. Systemic administration of analgesic drugs (e.g., opioids) may cause severe side effects, especially when given repeatedly8. Local anesthetics (LA; e.g., ropivacaine (RVC)) have been used widely as simple and effective treatment for persistent pain with absent or reduced adverse effects 39. However, their analgesic effect lasts only several hours after single injection41. (Source: The Journal of Pain)
Source: The Journal of Pain - July 28, 2020 Category: Materials Science Authors: Xue Tian, He Zhu, Shibin Du, Xue-Qing Zhang, Fuqing Lin, Fengtao Ji, Yung-Hao Tsou, Zhongyu Li, Yi Feng, Kathryn Ticehurst, Stephen Hannaford, Xiaoyang Xu, Yuan-Xiang Tao Tags: Original Reports Source Type: research

DACC Resting State Functional Connectivity as a Predictor of Pain Symptoms Following Motor Vehicle Crash: A Preliminary Investigation
Motor vehicle crashes (MVCs) are a leading cause of traumatic injuries in the United States – second only to falls – and account for over 20% of all severe injuries that require hospital care.21 While a host of negative outcomes accompany MVCs, chief among these is the experience of severe pain symptoms, which affect up to 80% of MVC survivors immediately after injury.9 In terms of the long-term prognosis of pain outcomes, there is considerable variability. Large-scale and population-based studies demonstrate that anywhere from 12-40% of MVC survivors continue to suffer from pain months after injury. (Source: The Journal of Pain)
Source: The Journal of Pain - July 27, 2020 Category: Materials Science Authors: Jacklynn M. Fitzgerald, Emily L. Belleau, Lauren E. Ehret, Colleen Trevino, Karen J. Brasel, Christine Larson, Terri deRoon-Cassini Source Type: research

En pointe: dancers report their pain less variably than do controls
The perception of pain derives from complex processes modulated at both spinal and super-spinal levels of the central nervous system. Its subjective nature and lack of a gold standard for objective markers impede accurate assessment and diagnosis, communication between patients and healthcare providers, and clinical care. Identifying factors affecting the variability of pain, and how the latter could be modulated, is of importance. (Source: The Journal of Pain)
Source: The Journal of Pain - July 19, 2020 Category: Materials Science Authors: Rita Canaipa, Diogo Mendon ça, Mariana Agostinho, Vanda Nascimento, Liat Honigman, Roi Treister Tags: Original Reports Source Type: research

Acceptance and Commitment Therapy for Primary Headache Sufferers: A Randomized Controlled Trial of Efficacy
Despite the efficacy of behavioral therapies (e.g., relaxation, biofeedback, cognitive-behavioral stress-management) and pharmacotherapy for headache management, only about half of patients present benefits that decline within several weeks after treatment [25]. These treatments focus on teaching patients to prevent headache mostly via avoidance of external and internal triggers (things or situations associated with headache emergence: e.g., foods, noises, lights, stress). Though these lead to increased awareness of risk factors and triggers associated with headaches [44], they contribute to the propagation that triggers s...
Source: The Journal of Pain - July 15, 2020 Category: Materials Science Authors: Vasilis S. Vasiliou, Evangelos C. Karademas, Yiolanda Christou, Savvas Papacostas, Maria Karekla Tags: Original Reports Source Type: research