[Problems in treating patients with chronic HCV infection due to the COVID-19 pandemic and during the lockdown phase in Germany].
s DHC-R Abstract BACKGROUND:  Healthcare services were faced with unprecedented challenges due to the COVID-19 pandemic and its associated lockdown regulations. In order to analyse the influence of the pandemic on the healthcare of patients with chronic hepatitis C in Germany, we carried out a structured questionnaire among all centres participating in the German Hepatitis C-Registry (DHC-R). METHODS:  320 centres of the DHC-R were invited to participate in an online survey. Of these, 74 centres had included ≥ 5 patients in the last 12 months. FINDINGS:  A fully answered questionnaire...
Source: Zeitschrift fur Gastroenterologie - November 9, 2020 Category: Gastroenterology Authors: Hüppe D, Niederau C, Serfert Y, Hartmann H, Wedemeyer H, für das DHC-R Tags: Z Gastroenterol Source Type: research

Not always eosinophilic esophagitis - intramural pseudodiverticulosis of the esophagus - a case report and literature review.
CONCLUSION:  The case report and the literature overview suggest that EIPD can be confounded with EoE. PMID: 33152792 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - November 5, 2020 Category: Gastroenterology Authors: Frieling T, Kreysel C, Blank M, Mülle D, Euler P, Melchior I Tags: Z Gastroenterol Source Type: research

Hepatocellular carcinoma with right atrial tumor thrombus.
CONCLUSIONS:  Advanced hepatocellular carcinoma with right atrial thrombus is an aggressive malignancy. Based on the results of median survival time, radiotherapy and TACE seemed to be associated with an improved prognosis and possible better survival. PMID: 33152793 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - November 5, 2020 Category: Gastroenterology Authors: Guo YX Tags: Z Gastroenterol Source Type: research

[Abraham Vater and the Papilla of Vater - From publication to medical term].
Abstract The name Abraham Vater is internationally associated with the confluence of the common bile duct and the pancreatic duct. Vater's writings were published 300 years ago along with the most important anatomical publications of that time. In his experiments, he examined in particular the merging of both ducts and their physiological significance. The major duodenal papilla is neither part of the experiments in this publication, nor does Vater describe it in detail. Rather, Abraham Vater collects and discusses the knowledge of this anatomical region in his writing. PMID: 33147636 [PubMed - as supplied by...
Source: Zeitschrift fur Gastroenterologie - November 4, 2020 Category: Gastroenterology Authors: Benter T, Meckelnborg C, Saklak M Tags: Z Gastroenterol Source Type: research

Colon diverticulosis is not a risk factor for the detection of  adenomatous polyps - results of a prospective study.
Colon diverticulosis is not a risk factor for the detection of adenomatous polyps - results of a prospective study. Z Gastroenterol. 2020 Nov 04;: Authors: Poszler A, Walter B, Aulehner-Forlenza C, Haller B, Abdelhafez M, Brown H, von Delius S, Born P, Schmid RM, Bajbouj M, Klare P Abstract BACKGROUND AND AIMS:  Colon diverticula (CD) and adenomatous polyps are frequently found during colonoscopy. Data from the literature contains inconsistent information about whether patients with CD have a higher risk for colon adenomas. A positive correlation might influence the current guidelines for sc...
Source: Zeitschrift fur Gastroenterologie - November 4, 2020 Category: Gastroenterology Authors: Poszler A, Walter B, Aulehner-Forlenza C, Haller B, Abdelhafez M, Brown H, von Delius S, Born P, Schmid RM, Bajbouj M, Klare P Tags: Z Gastroenterol Source Type: research

[Current state of under- and postgraduate education in abdominal  ultrasonography at German university hospitals. A panel study over 20 years].
CONCLUSIONS:  Training conditions have improved for medical staff as well as students despite the fact that there are still considerable differences in quality among the hospitals. The number of ultrasound scans is steadily increasing in all departments. The study did not show any adequate improvement in the availability of technical equipment. The German Society of Ultrasound in Medicine (DEGUM) has further strengthened its leading position in the field of sonography. PMID: 33045754 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - October 12, 2020 Category: Gastroenterology Authors: Welle R, Seufferlein T, Kratzer W Tags: Z Gastroenterol Source Type: research

Routine ileal intubation in colonoscopy does not increase the polyp detection rate: a retrospective study.
Abstract Colonoscopy is effective in the prevention and screening of colorectal cancer. Whether terminal ileal (TI) intubation is required during conventional colonoscopy and whether it offers clinical benefits with respect to polyp detection rate (PDR) remain unclear. This retrospective study included patients who underwent colonoscopy at our hospital between July 1, 2018 and April 20, 2019. The positive findings and time for TI intubation were recorded. Univariate and multivariate analyses were performed to identify factors associated with PDR. There were 1675 patients with cecal intubation colonoscopy, includin...
Source: Zeitschrift fur Gastroenterologie - October 1, 2020 Category: Gastroenterology Authors: Wang W, Chen K, Xu Y, Zhou Y, Chen P Tags: Z Gastroenterol Source Type: research

Verrucous carcinoma of the esophagus - a case report and literature review.
CONCLUSION:  The results suggest that macroscopic suspicion of verrucous esophageal carcinoma should lead to resections of larger tissue specimens by EMR to confirm the diagnosis. PMID: 33036050 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - October 1, 2020 Category: Gastroenterology Authors: Frieling T, Kreysel C, Blank M, Müller D, Euler P, Melchior I, Wullstein C, Hemmerlein B Tags: Z Gastroenterol Source Type: research

Autoimmune encephalitis and gastrointestinal dysmotility: achalasia, gastroparesis, and slow transit constipation.
CONCLUSION:  NAD may disturb gastrointestinal motility by altering various levels of the gut-brain axis. PMID: 33036051 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - October 1, 2020 Category: Gastroenterology Authors: Frieling T, Kreysel C, Blank M, Müller D, Melchior I, Euler P, Kuhlbusch-Zicklam R, Haarmeier T, Schemann M Tags: Z Gastroenterol Source Type: research

Addendum to S3-Guidelines Crohn's disease and ulcerative colitis: Management of Patients with Inflammatory Bowel Disease in the  COVID-19 Pandemic - open questions and answers.
Addendum to S3-Guidelines Crohn's disease and ulcerative colitis: Management of Patients with Inflammatory Bowel Disease in the COVID-19 Pandemic - open questions and answers. Z Gastroenterol. 2020 Oct;58(10):982-1002 Authors: Stallmach A, Sturm A, Blumenstein I, Helwig U, Koletzko S, Lynen P, Schmidt C, Dignass A, Kucharzik T, Collaborators: Abstract The COVID-19 pandemic is a global outbreak of new onset infections with the SARS-CoV-2 virus. To date, more than 3.4 million people have been infected throughout the world. In Germany, approximately 450,000 patients suffer from inflammatory bow...
Source: Zeitschrift fur Gastroenterologie - October 1, 2020 Category: Gastroenterology Authors: Stallmach A, Sturm A, Blumenstein I, Helwig U, Koletzko S, Lynen P, Schmidt C, Dignass A, Kucharzik T, Collaborators: Tags: Z Gastroenterol Source Type: research

[Association of Aspirin with Hepatocellular Carcinoma and Liver-Related Mortality].
PMID: 33036053 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - October 1, 2020 Category: Gastroenterology Authors: Kusnik A, Teufel A Tags: Z Gastroenterol Source Type: research

Das Europ äische Referenznetzwerk für seltene Lebererkrankungen (ERN RARE-LIVER): Betroffene Patienten besser versorgen, Konsilangebot für ärztliche Kollegen.
Das Europäische Referenznetzwerk für seltene Lebererkrankungen (ERN RARE-LIVER): Betroffene Patienten besser versorgen, Konsilangebot für ärztliche Kollegen. Z Gastroenterol. 2020 Oct;58(10):1006 Authors: Zecher B, Sebode M, Lohse AW PMID: 33036054 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - October 1, 2020 Category: Gastroenterology Authors: Zecher B, Sebode M, Lohse AW Tags: Z Gastroenterol Source Type: research

[Therapy of radiation-induced esophagits by oro-dispersible budesonide].
Abstract Radiation esophagitis is a common side effect of therapeutic radiotherapy. In this case report, we describe a patient with a complete remission of the esophagitis after therapy with an oro-dispersible budesonide formulation. PMID: 32937674 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - September 15, 2020 Category: Gastroenterology Authors: Reinshagen M, Hoffmann W Tags: Z Gastroenterol Source Type: research

[Challenges of the COVID-19 pandemic in gastrointestinal endoscopy: expectations and implementation of recommendations].
CONCLUSIONS:  Recommendations on structural measures were only partially fulfilled and cancellations of procedures were heterogeneous. Clear definitions of indications to perform endoscopies during such a pandemic are needed. Further, structural recommendations should be adapted and strategies to compensate financial losses need to be developed. PMID: 32937675 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - September 15, 2020 Category: Gastroenterology Authors: Damm M, Garbe J, Eisenmann S, Heidemann C, Krug S, Walter S, Lammert F, Michl P, Rosendahl J Tags: Z Gastroenterol Source Type: research

[Cost of illness of inflammatory bowel disease in Germany].
CONCLUSION:  For the first time, it is possible to compare existing medical costs for IBD in Germany. Current studies feature very heterogeneous methods and study populations of IBD. Depending on the collective, the total costs are up to 6485 Euro/patient/year. PMID: 32869213 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - August 30, 2020 Category: Gastroenterology Authors: Schnorbach MT, Kruis W Tags: Z Gastroenterol Source Type: research

[Declined Liver Grafts - Analysis of the German Donor Population from 2010 to 2018].
tschke J Abstract BACKGROUND:  The lack of suitable allografts limits the availability of liver transplantation in Germany. The quality of potentially available German donor livers has to date not been analyzed. METHODS:  Analysis of all donors for potential liver transplantations reported to the Eurotransplant by the German Organ Transplantation Foundation from 2010 to 2018. Categorization of transplanted and discarded organs utilizing available histopathological reports and predefined extended criteria for organ donation. RESULTS:  A total of 8594 livers were offered for transplantation,...
Source: Zeitschrift fur Gastroenterologie - August 23, 2020 Category: Gastroenterology Authors: Moosburner S, Raschzok N, Schleicher C, Bösebeck D, Gaßner JMGV, Ritschl PV, Rahmel A, Sauer IM, Pratschke J Tags: Z Gastroenterol Source Type: research

[Evaluation of abnormal liver chemistries in primary care - A survey on the prerequisites, procedure and challenges faced by general practitioners].
DISCUSSION:  It seems sensible to take measures that contribute to greater professionalization and standardization of primary care diagnostics and to a more structured cooperation with gastroenterological specialists. These include, for example, a broader range of training and further education formats, the development of a validated diagnostic pathway for classifying and evaluating elevated liver enzymes (especially early detection of patients at increased risk for liver fibrosis or liver cirrhosis) or the establishment of a liver function screening as part of the general medical check-up. The development of a GP-b...
Source: Zeitschrift fur Gastroenterologie - August 23, 2020 Category: Gastroenterology Authors: Wangler J, Jansky M Tags: Z Gastroenterol Source Type: research

A new exploration of white globe appearance (WGA) in ulcerative lesions.
This study aimed to further investigate the diagnostic value of WGA in differentiating non-cancerous lesions from EGC in ulcer-type cases. MATERIALS AND METHODS:  We retrospectively reviewed 54 cases of EGC and 155 cases of non-cancerous lesions in this study, all of which had endoscopic imaging data of ME-NBI scanning and pathological data of biopsy or resected specimens. The correlation of the prevalence of WGA and ulcerative lesions, as well as the characteristics of WGA between the 2 groups were analyzed in this study. RESULTS:  WGA was more common in ulcerative lesions (27.6 %, 21/76) than i...
Source: Zeitschrift fur Gastroenterologie - July 31, 2020 Category: Gastroenterology Authors: Cheng J, Xia J, Zhuang Q, Xu X, Wu X, Wan X, Wang J, Zhou H Tags: Z Gastroenterol Source Type: research

Response of advanced HCC to pembrolizumab and lenvatinib combination therapy despite monotherapy failure.
Abstract In recent years, immune checkpoint inhibitors (ICIs) were successfully introduced to cancer therapy, and these drugs have already become essential for the treatment of various noncurable tumors. However, monotherapy in advanced hepatocellular carcinoma (aHCC) failed to show statistically significant improvement.Recently, the combination of atezolizumab and bevacizumab demonstrated efficacy of combining ICI and VEGF inhibition, further substantiating previous data on synergistic mechanisms among respective substance classes.As TKI treatment is currently standard of care for aHCC, and ICIs are approved by t...
Source: Zeitschrift fur Gastroenterologie - July 31, 2020 Category: Gastroenterology Authors: Schulte N, Li M, Zhan T, Dreikhausen L, Sollors J, Antoni C, Diehl S, Schoenberg SO, Rahbari N, Reissfelder C, Giordano FA, Ebert MP, Teufel A Tags: Z Gastroenterol Source Type: research

[Non-severe Clostridioides difficile Infection: Are the data adequate to  give up metronidazole?]
[Non-severe Clostridioides difficile Infection: Are the data adequate to give up metronidazole?] Z Gastroenterol. 2020 Aug;58(8):778-784 Authors: Stallmach A, Katzer K, Reuken P Abstract Clostridioides difficile infections (CDI) are typical antibiotic therapy associated complications. Notwithstanding the fact that the clinical picture of CDI may extend to the development of a toxic megacolon with potentially life-threatening sequelae, mild infectious forms associated with uncomplicated diarrhoea are by far the most prevalent and should also be treated according to clear clinical practice guidelin...
Source: Zeitschrift fur Gastroenterologie - July 31, 2020 Category: Gastroenterology Authors: Stallmach A, Katzer K, Reuken P Tags: Z Gastroenterol Source Type: research

[Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria].
l U PMID: 32785915 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - July 31, 2020 Category: Gastroenterology Authors: Stölzel U Tags: Z Gastroenterol Source Type: research

[IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease].
PMID: 32785916 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - July 31, 2020 Category: Gastroenterology Authors: Reinshagen M Tags: Z Gastroenterol Source Type: research

[Limits of the G-DRG system to reflect Complexity in German University Hospitals].
Abstract Since the introduction of the G-DRG-system in Germany for the reimbursement of in-hospital patients in 2003 the Institute for the Hospital Remuneration System (InEK) annually determines case reimbursements for currently 1300 individual diagnosis-related groups (DRGs). These are based on the cost documentation of 200 representative hospitals, coopted by InEK (§ 21-KHEntG-dataset). Since DRGs represent cost averages, one half of German hospitals would be expected to report an annual income surplus, the other half a deficit. In spite of sustained cost reductions two thirds of public University Hospita...
Source: Zeitschrift fur Gastroenterologie - July 21, 2020 Category: Gastroenterology Authors: Lerch MM, Rathmayer M, Siegmund B, Wilke M, Wedemeyer H, Stallmach A, Mayerle J, Lammert F Tags: Z Gastroenterol Source Type: research

Klug entscheiden – Editorial.
Klug entscheiden – Editorial. Z Gastroenterol. 2020 Jul;58(7):638 Authors: Jansen PL, Lammert F PMID: 32659824 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - June 30, 2020 Category: Gastroenterology Authors: Jansen PL, Lammert F Tags: Z Gastroenterol Source Type: research

[Choose wisely - a critical assessment].
PMID: 32659825 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - June 30, 2020 Category: Gastroenterology Authors: Zeuzem S Tags: Z Gastroenterol Source Type: research

["Choosing wisely" - mission and aims].
["Choosing wisely" - mission and aims]. Z Gastroenterol. 2020 Jul;58(7):642-644 Authors: Lynen Jansen P, Siegmund B Abstract "Klug entscheiden" addresses the problem of over- and undersupply in medicine. Following the American model "Choosing wisely" an interdisciplinary team of all internal medicine societies develops evidence-based recommendations to improve the quality of indications. In contrast to guidelines, the initiative does not provide comprehensive medical recommendations, but focuses on problems that are particularly relevant to health care. In addition, it is...
Source: Zeitschrift fur Gastroenterologie - June 30, 2020 Category: Gastroenterology Authors: Lynen Jansen P, Siegmund B Tags: Z Gastroenterol Source Type: research

[Choosing wisely - perspectives: what are the key questions?]
Abstract Gastroenterology offers a wide field for future "choosing wisely" recommendations (CWR). They should refer not only to an under- or overuse of diagnostic tools like laboratory or imaging tests but also to an evidence-based application of drug therapies und endoscopic interventions. Drugs like antibiotics or proton pump inhibitors are both often prescribed in the absence of clearly defined underlying diseases and not given when an indication is clear. Similar is true for the ordering of abdominal imaging methods. Computerized tomography of the abdomen too often is preferred over a qualified ultra...
Source: Zeitschrift fur Gastroenterologie - June 30, 2020 Category: Gastroenterology Authors: Holstege A Tags: Z Gastroenterol Source Type: research

[Implementing choosing wisley in undergraduate medical education].
r J Abstract The principles of evidence-based medicine and the "choosing wisley" initiatives create a foundation for patient-centred medicine, which can prevent an overuse or undertreatment for patients. In order to achieve nationwide implementation in Germany, it makes sense to anchor the necessary skills, in particular scientific skills, more firmly in medical studies and to test them in the state exams. With the "Masterplan Medizinstudium 2020", undergraduate medical education should focus more on the teaching and learning of skills and abilities, instead of on the strong tradition of impart...
Source: Zeitschrift fur Gastroenterologie - June 30, 2020 Category: Gastroenterology Authors: Stallmach A, Jünger J Tags: Z Gastroenterol Source Type: research

[Choosing wisely: Previously published gastroenterological recommendations of the "Klug entscheiden"-initiative].
[Choosing wisely: Previously published gastroenterological recommendations of the "Klug entscheiden"-initiative]. Z Gastroenterol. 2020 Jul;58(7):645-651 Authors: van Leeuwen P Abstract This chapter is a summary of gastroenterological recommendations published as part of the "Klug entscheiden"-initiative. PMID: 32659829 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - June 30, 2020 Category: Gastroenterology Authors: van Leeuwen P Tags: Z Gastroenterol Source Type: research

[Addendum to S3-Guidelines Crohn's disease and ulcerative colitis: Management of Patients with Inflammatory Bowel Disease in the  COVID-19 Pandemic - open questions and answers].
[Addendum to S3-Guidelines Crohn's disease and ulcerative colitis: Management of Patients with Inflammatory Bowel Disease in the COVID-19 Pandemic - open questions and answers]. Z Gastroenterol. 2020 Jul;58(7):672-692 Authors: Autoren, Collaborators: PMID: 32659830 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - June 30, 2020 Category: Gastroenterology Authors: Autoren, Collaborators: Tags: Z Gastroenterol Source Type: research

[A new horizon in the primary diagnosis of pancreatic cancer].
PMID: 32659831 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - June 30, 2020 Category: Gastroenterology Authors: Bornschein J Tags: Z Gastroenterol Source Type: research

[Screening gastroscopy in Germany - first results of the pilot phase of the Pr ä-GIT study].
CONCLUSION:  The Prä-GIT study was designed to generate a database for premalignant and early cancerous lesions of the uGIT in Germany in asymptomatic individuals presenting for a regular screening colonoscopy. The current pilot study has delivered important insights into the feasibility of the main study protocol. Additionally, the pilot study has shown a high rate of acceptance of an additional uGIT examination in this study population. PMID: 32572870 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - June 21, 2020 Category: Gastroenterology Authors: Ebigbo A, Römmele C, Meisinger C, Probst A, Beyer A, Arnold J, Beer F, Endlicher E, Schiffelholz W, Linseisen J, Messmann H Tags: Z Gastroenterol Source Type: research

[Yoghurt-induced Lactobacillus bacteremia in a patient with Crohn's disease on therapy with ustekinumab and concomitant HIV-Infection].
We report about a patient with Crohn's disease and HIV-infection, who developed a septicemia. A Lactobacillus-bacteremia was diagnosed, the causative agents could be traced back to the consumption of self-made yoghurt. The utility of probiotics in IBD patients with underlying immune-compromising diseases is a risk which is difficult to predict, therefore their use in these patients should be discouraged. PMID: 32572871 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - June 21, 2020 Category: Gastroenterology Authors: Haziri D, Prechter F, Stallmach A Tags: Z Gastroenterol Source Type: research

[Diagnostic quality of transluminal biopsy in undetermined biliary duct stenosis by primary PTCD with "cross and push" technique - a  prospective monocentric pilot study].
CONCLUSION:  This prospective cohort-study shows a high diagnostic precision for the percutaneous transductal biopsy-set to evaluate an undetermined biliary duct stenosis-particularly in biliary processes. Because it can be difficult to gain histology in malignant biliary duct processes using different methods, the "cross and push" biopsy completes the spectrum of diagnostic procedures. PMID: 32572872 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - June 21, 2020 Category: Gastroenterology Authors: Lutz HH, Trautwein C, Tischendorf JJW Tags: Z Gastroenterol Source Type: research

Work satisfaction and burnout risk of gastroenterologists in Germany: results of a nationwide survey.
This study examines the risk of burnout and job satisfaction among gastroenterologists in Germany. METHODS:  An electronic survey was distributed to gastroenterologists organized mainly in the Federal Organization of Gastroenterology in Germany (BVGD, Berufsverband Gastroenterologie Deutschland e. V.). In addition to general demographic variables, job satisfaction was determined using the Work Satisfaction Questionnaires (WSQ), and burnout risk was determined using the Maslach Burnout Inventory (MBI). RESULTS:  A representative sample of gastroenterologists organized in the BVGD (Berufsverband Gastroe...
Source: Zeitschrift fur Gastroenterologie - June 7, 2020 Category: Gastroenterology Authors: Adarkwah CC, Labenz J, Birkner B, Beilenhoff U, Hirsch O Tags: Z Gastroenterol Source Type: research

Small intestinal dysmotility in cirrhotic patients: correlation with severity of liver disease and cirrhosis-associated complications.
In this study, both fasting and postprandial manometric tracings of 24-hour antroduodenojejunal manometries were analyzed using both visual analysis and computer-aided analysis. RESULTS:  In 34 patients (83 %), the mean migrating motor complex (MMC) cycle length was different compared with healthy controls. Phase II was prolonged in 27 patients (66 %), while phase I showed a reduced duration in 23 (56 %) and in phase III in 13 individuals (32 %). We also observed special motor patterns, e. g., migrating clustered contractions (MCCs) or retrograde clustered contractions (RCCs), which were present during ...
Source: Zeitschrift fur Gastroenterologie - June 7, 2020 Category: Gastroenterology Authors: Gundling F, Luxi M, Seidel H, Schepp W, Schmidt T Tags: Z Gastroenterol Source Type: research

[Best supportive care in a young patient with locally advanced MSI-high colon cancer?]
Abstract Molecular diagnostics are increasingly important to guide treatment decisions in oncologic patients. For instance, the presence of high-grade microsatellite-instability (MSI-high) is considered to be one of the major positive predictors of therapy response to immune-checkpoint inhibitors in patients with solid tumors. Based on impressive results from several immune-oncology trials, the American Food and Drug Administration (FDA) granted approval to immunotherapy in any previously treated, MSI-high solid cancer in 2017. Here, we report the clinical case of a young patient with MSI-high colorectal cancer. T...
Source: Zeitschrift fur Gastroenterologie - June 4, 2020 Category: Gastroenterology Authors: Welland S, De Castro T, Wirth T, Kleine M, Ringe KI, Saborowski A, Vogel A Tags: Z Gastroenterol Source Type: research

[Online-based, qualified second opinion for patients with colorectal cancer - A pilot study of the Felix Burda Foundation in co-operation with the Network against Colorectal Cancer].
CONCLUSION:  Generating an online-based, qualified second opinion by an interdisciplinary tumour board is technically and logistically well feasible. The online-based second opinion could significantly improve the quality of treatment for patients with colorectal cancer in the future and thus improve their quality of life. PMID: 32450585 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - May 24, 2020 Category: Gastroenterology Authors: Berger U, Beckenbauer UE, Rimkus C, Bader FG, Seufferlein TTW, Maar C Tags: Z Gastroenterol Source Type: research

[Full thickness resection of a pyloric adenoma in the proximal duodenum in a 67-year-old patient with attenuated polyposis coli].
CONCLUSION:  Herein we present the first case of duodenal EFTR in a patient with attenuated FAP and a PGA. There are currently no specific guidelines for the removal and surveillance. ASGE recommends resection and surveillance endoscopy at 3-5 years interval. PMID: 32380553 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - May 6, 2020 Category: Gastroenterology Authors: Anliker O, Sieweke W, Töpfer A, Wülker I, Breidert M Tags: Z Gastroenterol Source Type: research

[Removal of an Uncovered Metal Stent from the Common Bile Duct Six  Years after Implantation in Chronic Calcifying Pancreatitis].
We report a patient with chronic calcifying pancreatitis and cholestasis who, after unsuccessful multistenting with a total of 15 stent changes, was implanted with an uncoated metal stent in the common bile duct as second-line therapy. After this stent had been in place for six years and had to be balloon-cleaned 19 times during this time, the indication for removal came up. A fully coated metal stent of the same diameter but 2 cm longer was inserted into the lumen of the uncoated stent. It was left in place for 9 months and cleaned once during this time. Then, via ERCP, both stents were extended in a telescope-like ma...
Source: Zeitschrift fur Gastroenterologie - May 6, 2020 Category: Gastroenterology Authors: Hentschel F, Lüth S Tags: Z Gastroenterol Source Type: research

Rare heterochronous liver and pancreatic multiple primary cancers: a case report and literature review.
We report this case to raise the clinician's attention to the disease because the long-term survival rate can be effectively improved by timely diagnosis and appropriate treatment. For patients with HCV-positive primary cancers, active antiviral therapy should be simultaneously provided with antitumor therapy, thereby effectively reducing the incidence of MPC. PMID: 32380555 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - May 6, 2020 Category: Gastroenterology Authors: Zhang W, Xiao F, Li J, Guo X, Lin Z, Huang Z, Mao N, Sun B, Wang G Tags: Z Gastroenterol Source Type: research

Bouveret's Syndrome - Case Series with Therapeutic Implications.
Abstract Bouveret's syndrome is a rare complication resulting from gallstone disease. Both surgical and endoscopical procedures are performed, with the disease to be seen as strictly interdisciplinary. There are no well-established recommendations for this condition. In this paper, we want to describe our experience from 6 cases in 3 Swiss hospitals from 2015 to 2017 with emphasis on the endoscopic technique of electrohydraulic lithotripsy followed by balloon dilatation and propose a treatment algorithm. PMID: 32353887 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - March 31, 2020 Category: Gastroenterology Authors: Kukiolka T, Borovicka J, Baumeler S, Schiesser M, Gubler C Tags: Z Gastroenterol Source Type: research

[3 unusual courses of gastrointestinal MALT lymphoma].
We report on the unusual course of disease in three patients with gastrointestinal MALT lymphoma. Special features are the primary lymphoma manifestation, the high-grade transformation during the follow up, the long-time interval between initially curative intended therapy and relapse and the occurrence of another neoplasia in one case. This demonstrates that despite their good prognosis in general, follow-up investigations of gastrointestinal MALT lymphoma are reasonable. PMID: 32353888 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - March 31, 2020 Category: Gastroenterology Authors: Fischbach W, Eck M, Dorlöchter C Tags: Z Gastroenterol Source Type: research

[Inderdisciplinary care of patients with short-bowel-syndrome in  Germany: A comparative Cost-of-Illness analysis of in- and outpatient care].
CONCLUSIONS:  The interdisciplinary medical care of SBS-patients is resource-intensive and expensive. The required treatment shifts from the in- to the outpatient sector. Both settings are at present not adequately reimbursed. Hence, this imbalance may endanger adequate care for SBS-patients in the future in times of economic rationale. In concordance with other rare disease management programs, additional measures are needed to provide and improve interdisciplinary treatment of SBS. PMID: 32353889 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - March 31, 2020 Category: Gastroenterology Authors: Muazzam MN, Hauk C, Arensmeyer J, Hausen A, Koeppen P, Kalff JC, von Websky MW Tags: Z Gastroenterol Source Type: research

[Successful intraductal radiofrequency ablation of residual adenoma tissue following endoscopic papillectomy].
We report about two patients with papillary adenoma who had residual adenoma in the center of the ductus hepatocholedochus papillary region after endoscopic papillectomy. Due to missing possibility of further endoscopic resection we carried out endobiliary radiofrequency ablation instead of surgical treatment. In follow-up examination, there where no macroscopic or histological relapse, therefore endobiliary radiofrequency ablation needs to be discussed as an alternative to surgical therapy option. PMID: 32198738 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - February 29, 2020 Category: Gastroenterology Authors: Gereitzig N, Ziegan RA, Tischendorf JJW Tags: Z Gastroenterol Source Type: research

[Paradigm shift in understanding Acute kidney injury in patients with  chronic liver disease: From pathophysiology to defining disease entities].
[Paradigm shift in understanding Acute kidney injury in patients with chronic liver disease: From pathophysiology to defining disease entities]. Z Gastroenterol. 2020 Mar;58(3):254-266 Authors: Scurt FG, Bose K, Canbay A, Mertens PR, Chatzikyrkou C Abstract The hepatorenal syndrome (HRS) is only a part of the wide spectrum of renal injury in patients with end-stage liver cirrhosis. Besides that, the advanced liver disease itself, or its underlying causes, as well as comorbidities, like diabetes mellitus, adiposity and arterial hypertension, can directly cause parenchymal renal insults (bile ...
Source: Zeitschrift fur Gastroenterologie - February 29, 2020 Category: Gastroenterology Authors: Scurt FG, Bose K, Canbay A, Mertens PR, Chatzikyrkou C Tags: Z Gastroenterol Source Type: research

An den Editor – 16.01.2020.
An den Editor – 16.01.2020. Z Gastroenterol. 2020 Mar;58(3):267 Authors: PMID: 32198740 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - February 29, 2020 Category: Gastroenterology Tags: Z Gastroenterol Source Type: research

[Erlotinib plus Gemcitabine in metastatic pancreatic cancer: Results  from a non-interventional trial].
In conclusion, these results from the daily treatment routine of metastatic pancreatic cancer underline the importance of combined gemcitabine/erlotinib therapy for a subgroup of patients who develop a rash in the course of erlotinib treatment. PMID: 32052394 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - February 11, 2020 Category: Gastroenterology Authors: Westphalen CB, Heinemann V, Tessen HW, Groschek M, Hoeffkes HG, Marschner N, Schulze M, Beringer A, Waldschmidt D Tags: Z Gastroenterol Source Type: research

Ustekinumab serum concentrations are associated with clinical outcomes in Crohn's disease - a regional multi-center pilot study.
CONCLUSION:  Trough concentrations of UST 8 weeks after induction predict clinical response to therapy in week 16 with moderate sensitivity and specificity. TDM using LC-MSMS could prove beneficial in personalized UST therapy of patients with CD by identifying individuals with subtherapeutic concentrations who might benefit from dose escalation. PMID: 32045954 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - February 10, 2020 Category: Gastroenterology Authors: Thomann AK, Schulte LA, Globig AM, Hoffmann P, Klag T, Itzel T, Teufel A, Schreiner R, Scheffe N, Ebert MP, Wehkamp J, Gauss A, Hasselblatt P, Klaus J, Reindl W Tags: Z Gastroenterol Source Type: research

[Current standard of antibiotic prophylaxis in esophageal varices bleeding in Germany].
CONCLUSION:  Our study shows that the applied standards for antibiotic prophylaxis in esophageal varices bleeding varies greatly in Germany. Future studies about the necessary duration of prophylaxis and its dependency from the Child-Pugh-Score are needed so that unnecessary antibiotic prescriptions can be avoided. The avoidance of antibiotic prophylaxis in elective banding of non-bleeding esophageal varices, which is not recommended by guidelines and was used by about 20 % of participants in our study, can already reduce antibiotic use. PMID: 32045955 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - February 10, 2020 Category: Gastroenterology Authors: Zhelegu I, Ebert MP, Vogelmann R Tags: Z Gastroenterol Source Type: research