[Proton pump inhibitors in patients with liver cirrhosis - a survey among hepatologists in Germany].
CONCLUSION:  PPI are frequently prescribed among patients with liver cirrhosis in Germany. Prescribers are aware of an unclear risk-benefit ratio. Further prospective data are urgently needed to increase evidence regarding indication and duration of PPI therapy in patients with cirrhosis. PMID: 31170742 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - June 1, 2019 Category: Gastroenterology Authors: Horvatits T, Drolz A, Wehmeyer M, Steib C, Trebicka J, Lohse AW, Kluwe J Tags: Z Gastroenterol Source Type: research

Clinical management of eosinophilic esophagitis - a nationwide survey among gastroenterologists in Germany.
CONCLUSIONS:  Among gastroenterologists in Germany, substantial variation in the adherence to published EoE guidelines appears to exist. This indicates the need for intensified education and national guidelines in order to optimize and harmonize the clinical management of EoE patients. PMID: 31170743 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - June 1, 2019 Category: Gastroenterology Authors: Miehlke S, von Arnim U, Schlag C, Frieling T, Madisch A, Loibl R, Mainz D, Labenz J Tags: Z Gastroenterol Source Type: research

[Artificial Intelligence in Endoscopy: Deep Neural Nets for  Endoscopic Computer Vision - Methods & Perspectives].
[Artificial Intelligence in Endoscopy: Deep Neural Nets for Endoscopic Computer Vision - Methods & Perspectives]. Z Gastroenterol. 2019 Jun;57(6):767-780 Authors: Schmitz R, Werner R, Rösch T Abstract Artificial neural networks, as a specific approach towards artificial intelligence (AI), can open up a variety of new perspectives for endoscopy, such as automated lesion detection and the precise prediction of a lesion's histology by its endoscopic appearance. Whilst early experiments do suggest an enormous potential for these methods, public expectations on their application in vario...
Source: Zeitschrift fur Gastroenterologie - June 1, 2019 Category: Gastroenterology Authors: Schmitz R, Werner R, Rösch T Tags: Z Gastroenterol Source Type: research

[OLGA-gastritis - predictor for gastric cancer?]
PMID: 31170745 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - June 1, 2019 Category: Gastroenterology Authors: Martin K, Bajbouj M Tags: Z Gastroenterol Source Type: research

Leserbrief zum Beitrag: „Gesunde Lebensführung reduziert KRK-Risiko“.
Leserbrief zum Beitrag: „Gesunde Lebensführung reduziert KRK-Risiko“. Z Gastroenterol. 2019 Jun;57(6):784 Authors: Carr PR, Hoffmeister M PMID: 31170746 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - June 1, 2019 Category: Gastroenterology Authors: Carr PR, Hoffmeister M Tags: Z Gastroenterol Source Type: research

[Updated S2k-Guideline "Complications of liver cirrhosis". German Society of Gastroenterology (DGVS)].
[Updated S2k-Guideline "Complications of liver cirrhosis". German Society of Gastroenterology (DGVS)]. Z Gastroenterol. 2019 May 06;: Authors: Gerbes AL, Labenz J, Appenrodt B, Dollinger M, Gundling F, Gülberg V, Holstege A, Lynen-Jansen P, Steib CJ, Trebicka J, Wiest R, Zipprich A, Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV), Deutsche Gesellschaft für Innere Medizin e. V. (DGIM), Deutsche Gesellschaft für Infektiologie e. V. (DGI), Deutsche Gesellschaft für Pathologie e. V./Bundesverband deutscher Pathologen e. V. (DGP/BDP), Deutsche Röntge...
Source: Zeitschrift fur Gastroenterologie - May 6, 2019 Category: Gastroenterology Authors: Gerbes AL, Labenz J, Appenrodt B, Dollinger M, Gundling F, Gülberg V, Holstege A, Lynen-Jansen P, Steib CJ, Trebicka J, Wiest R, Zipprich A, Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV), Deutsche Gesellschaft für Innere Medizin e. Tags: Z Gastroenterol Source Type: research

Contrast-enhanced imaging in hepatic epithelioid hemangioendothelioma: retrospective study of 10 patients.
CONCLUSIONS:  Knowledge of the different characteristic CEUS patterns is of importance to avoid misdiagnosis due to resemblance of patterns A and B to the much more common focal liver lesions hemangioma and intrahepatic cholangiocarcinoma. Of importance, sonographers should be aware that wash-out in the PVLP might be absent in some patients. PMID: 30986884 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - April 15, 2019 Category: Gastroenterology Authors: Klinger C, Stuckmann G, Dietrich CF, Berzigotti A, Horger MS, Debove I, Gilot BJ, Pauluschke-Fröhlich J, Hoffmann T, Sipos B, Fröhlich E Tags: Z Gastroenterol Source Type: research

[Ulcerative colitis: Does the modulation of gut microbiota induce long-lasting remission?]
Abstract Although the pathogenesis of ulcerative colitis (UC) remains elusive, substantial progress in understanding its development and progression has been achieved in the past decades, and novel effective treatment strategies have been developed. Changes in gut microbiota, environmental triggers, deregulation of immunological responses, and genetic predisposition have been identified as pathogenic key factors. There are several lines of clinical observations, which support a close connection of altered gut microbiota with the development and course of UC. Despite a plethora of microbiota alterations in UC, it i...
Source: Zeitschrift fur Gastroenterologie - April 15, 2019 Category: Gastroenterology Authors: Stallmach A, Grunert P, Pieper D, Steube A Tags: Z Gastroenterol Source Type: research

[Primary bile acid diarrhea in a community gastroenterology practice].
Abstract When first described in 1976, primary bile acid diarrhea (BAD Type 1) was regarded as a very rare cause of chronic diarrhea. Today, the incidence is estimated as> 1 %. Availability of diagnostic tools varies widely and, in Germany, there is no generally consented recommendation for their use. BAD is still widely underdiagnosed.Since the beginning of the '90 s, we have added a therapeutic trial with cholestyramine to our diagnostic approach of chronic diarrhea. Patients with a positive test were offered a Selenium-homocholic acid taurine (SeHCAT) test for confirmation of bile-acid-diarrhea (BA...
Source: Zeitschrift fur Gastroenterologie - April 15, 2019 Category: Gastroenterology Authors: Wenzel H Tags: Z Gastroenterol Source Type: research

Perceived distress, personality characteristics, coping strategies and psychosocial impairments in a national German multicenter cohort of patients with Crohn's disease and ulcerative colitis.
This study examined differences in personality, psychological distress, and stress coping in inflammatory bowel disease (IBD) depending on type of disease and disease activity. We compared patients suffering from Crohn's disease (CD) and ulcerative colitis (UC) with controls. While the literature is replete with distinctive features of the pathogenesis of IBD, the specific differences in psychological impairments are not well studied. METHODS:  In this German national multicenter study, participants were recruited from 32 centers. Two hundred ninety-seven questionnaires were included, delivering vast information ...
Source: Zeitschrift fur Gastroenterologie - April 1, 2019 Category: Gastroenterology Authors: Petruo VA, Krauss E, Kleist A, Hardt J, Hake K, Peirano J, Krause T, Ehehalt R, von Arnauld de la Perriére P, Büning J, Treml O, Krauss N, Albrecht H, Felten G, Hermannspahn U, Burkhardt U, Eisold M, Teich N, Siegmund B, Maaser C, Bokemeyer B, Baumgart Tags: Z Gastroenterol Source Type: research

Efficacy of palliative chemotherapy in elderly patients with colorectal cancer.
CONCLUSION:  Old patients can profit from palliative chemotherapy to the same extent as younger ones. PMID: 30965378 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - April 1, 2019 Category: Gastroenterology Authors: Bohle W, Pachlhofer A, Zoller WG Tags: Z Gastroenterol Source Type: research

The "Aachen sings" study ("Aachen choir engagement study into GERD symptoms"): moderate singing and breathing exercises in a choir reduce reflux symptoms - a cohort study in non-specialist choristers.
The "Aachen sings" study ("Aachen choir engagement study into GERD symptoms"): moderate singing and breathing exercises in a choir reduce reflux symptoms - a cohort study in non-specialist choristers. Z Gastroenterol. 2019 Apr;57(4):491-496 Authors: Dietrich CG, Kottmann T, Labenz J, Streetz K, Hellebrandt P Abstract BACKGROUND:  The influence of singing activities and breathing exercises on the presence of gastroesophageal reflux disease (GERD) symptoms is not clear. While an Austrian study found symptom reduction, an Italian study showed more symptoms in professional opera c...
Source: Zeitschrift fur Gastroenterologie - April 1, 2019 Category: Gastroenterology Authors: Dietrich CG, Kottmann T, Labenz J, Streetz K, Hellebrandt P Tags: Z Gastroenterol Source Type: research

Pharmacological treatment of hepatocellular carcinoma with cavoatrial tumor thrombus - case series and literature review.
Abstract Hepatocellular carcinomas (HCC) that extend into the vena cava and the right atrium have a poor prognosis. Surgical approaches including partial hepatectomy and thrombectomy are the most frequently reported treatment options. However, most patients with advanced HCC are not eligible for complex surgical interventions due to reduced liver function, comorbidities, and metastases. At the same time, systemic treatment options of HCC have expanded in recent years. Here, we report 3 cases of patients with advanced HCC who developed a cavoatrial tumor thrombus (CATT) after initial surgical or interventional ther...
Source: Zeitschrift fur Gastroenterologie - April 1, 2019 Category: Gastroenterology Authors: Zhan T, Sollors J, Steinebrunner N, Schlitt HJ, Stroszczynski C, Weiss KH, Ebert MP, Teufel A Tags: Z Gastroenterol Source Type: research

Nonalcoholic steatohepatitis (NASH) - current treatment recommendations and future developments.
This article reviews the scientific findings of epidemiology, diagnostic, and therapeutic management of NAFLD. Lifestyle modifications (low-caloric Mediterranean diet and exercise training) to reduce weight are a major factor in the treatment of NAFLD.Pharmacological therapies may be useful in patients with NASH and fibrosis as well as nonresponders to lifestyle modifications. Currently, however, no pharmacological substances are approved for the indication NASH. PMID: 30965381 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - April 1, 2019 Category: Gastroenterology Authors: Roeb E, Geier A Tags: Z Gastroenterol Source Type: research

[Gluten-free diet and low FODMAP diet: no or minor evidence for treating irritable bowel syndrome].
PMID: 30965382 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - April 1, 2019 Category: Gastroenterology Authors: Madisch A Tags: Z Gastroenterol Source Type: research

Gastric cancer and paraneoplastic dermatomyositis as complications of an unrecognized juvenile polyposis syndrome.
We report the case of a 49-year-old woman presenting with proximal muscle weakness, weight loss, severe anemia, and melena. One year before, the diagnosis of a "fundic gland polyposis" was presumed after endoscopic evaluation for iron deficiency anemia had shown numerous polyps limited to the gastric mucosa. On admission, the diagnosis of dermatomyositis was made based on laboratory results with a marked elevated creatine kinase as well as the presence of characteristic clinical findings and muscle histology. Upper endoscopy revealed multiple pedunculated, edematous polyps in the stomach without apparent cancerou...
Source: Zeitschrift fur Gastroenterologie - March 14, 2019 Category: Gastroenterology Authors: Schiemer M, Schmitt-Graeff A, Brass V, Hasselblatt P Tags: Z Gastroenterol Source Type: research

Tolerability of FODMAP - reduced diet in irritable bowel syndrome - efficacy, adherence, and body weight course.
CONCLUSION:  FODMAP reduced diet is an efficient therapy in IBS. However, adherence of the patients is poor and the therapy bears the risk of significant weight loss. PMID: 30873577 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - March 14, 2019 Category: Gastroenterology Authors: Frieling T, Heise J, Krummen B, Hundorf C, Kalde S Tags: Z Gastroenterol Source Type: research

Perianal fistulas in adult patients with Crohn's disease in Germany - a  retrospective cross-sectional analysis of claims data from German sickness funds.
This study aims to gain representative data on the prevalence, characteristics, and treatment of CD patients suffering from PF in Germany. MATERIALS AND METHODS:  A retrospective cross-sectional analysis of claims data from several German company health insurance funds included adult patients with CD and PF in 2015. The dataset comprised in- and outpatient services with diagnoses, drug prescriptions, and other patient data. It is representative for age, gender, and region and allows extrapolation to the total German statutory health insurance (SHI) population. A systematic literature review was conducted to discu...
Source: Zeitschrift fur Gastroenterologie - March 14, 2019 Category: Gastroenterology Authors: Georgiadou E, Fanter L, Brandes A, Ratsch BA, Friedel H, Dignass A Tags: Z Gastroenterol Source Type: research

Leitlinienreport der S3-Leitlinie Diagnostik und Therapie der Plattenepithelkarzinome und Adenokarzinome des Ösophagus.
Leitlinienreport der S3-Leitlinie Diagnostik und Therapie der Plattenepithelkarzinome und Adenokarzinome des Ösophagus. Z Gastroenterol. 2019 Mar;57(3):e103-e119 Authors: Porschen R, Langer T, van Leeuwen P PMID: 30861551 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - March 1, 2019 Category: Gastroenterology Authors: Porschen R, Langer T, van Leeuwen P Tags: Z Gastroenterol Source Type: research

Die aktualisierte Ösophaguskarzinom-Leitlinie: Konzept der „living guideline“.
Die aktualisierte Ösophaguskarzinom-Leitlinie: Konzept der „living guideline“. Z Gastroenterol. 2019 Mar;57(3):295 Authors: PMID: 30861552 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - March 1, 2019 Category: Gastroenterology Tags: Z Gastroenterol Source Type: research

[Patient perception and approval of fecal microbiota transplantation (FMT) as an alternative treatment option for ulcerative colitis].
CONCLUSION:  For the majority of the UC patients surveyed, FMT represents a feasible treatment option. Approximately half of the respondents would consider FMT as an alternative treatment option, even inspite of a satisfactory disease response to current standard therapies. Unsurprisingly, there are concerns regarding the transmission of possible infectious agents and the hygienic implementation of FMT itself. PMID: 30861553 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - March 1, 2019 Category: Gastroenterology Authors: Roggenbrod S, Schuler C, Haller B, Sohn M, Storr M, Schepp W, Gundling F Tags: Z Gastroenterol Source Type: research

Peroral endoscopic myotomy versus pneumatic dilation - result from a retrospective study with 1-year follow-up.
Abstract BACKGROUND AND AIMS:  On the basis of lesser rates of major adverse events and a short-term efficacy as Heller's myotomy, there is a growing enthusiasm in favor of peroral endoscopic myotomy (POEM), whereas study comparing POEM and pneumatic dilatation (PD) is quite rare. The aim of this study was to evaluate the efficacy of POEM and PD in Chinese achalasia patients in a retrospectively designed study. METHODS:  Patients with achalasia, who underwent either PD (n = 26) or POEM (n = 40) were retrospectively recruited from September 2010 through March 2016 at a single tertiary cente...
Source: Zeitschrift fur Gastroenterologie - March 1, 2019 Category: Gastroenterology Authors: Zheng Z, Zhao C, Su S, Fan X, Zhao W, Wang B, Jin H, Zhang L, Wang T, Wang B Tags: Z Gastroenterol Source Type: research

Severe ileocecal inflammatory syndrome in adult patients with cystic fibrosis.
We report on 2 adult patients with prior lung transplantation who presented with a severe inflammatory disorder of the ileocecal region. One patient underwent ileocecal resection; the second patient died after emergency surgery for intestinal perforation. Both cases did not show typical signs of CF-related distal intestinal obstruction syndrome or extensive fibrosing colonopathy. However, the clinical and histopathological findings revealed CF-induced inflammatory alterations of the intestinal mucosa. Thus, these cases illustrate a further CF-related bowel disorder, which can be especially relevant in long-term CF sur...
Source: Zeitschrift fur Gastroenterologie - March 1, 2019 Category: Gastroenterology Authors: Henker R, Oltmanns A, Wald A, Tuennemann J, Opitz S, Hoffmeister A, Wirtz H, Mössner J, Jansen-Winkeln B, Karlas T Tags: Z Gastroenterol Source Type: research

[Barrett-Screening: Rational, current concepts and perspectives].
ockel I Abstract Though showing an increasing incidence over the past 20 years, esophageal adenocarcinoma (EAC) remains a rather uncommon cancer (i. e., compared to colorectal and gastric cancer). Once detected, the prognosis of this cancer entity is still very poor. Hence, in spite of some unfavorable prerequisites to systematic screening, the development of a screening concept for Barrett's esophagus (BE) and EAC seems worthwhile. Nowadays, screening for BE and EAC is based on conventional endoscopy, mostly conducted individually in patients with reflux complaints (gastroesophageal reflux disease-GERD). B...
Source: Zeitschrift fur Gastroenterologie - March 1, 2019 Category: Gastroenterology Authors: Weismüller J, Thieme R, Hoffmeister A, Weismüller T, Gockel I Tags: Z Gastroenterol Source Type: research

Imaging of toxocariasis.
Abstract Parasitäre Erkrankungen werden in Europa relativ selten diagnostiziert und behandelt. Somit sind auch klinische Besonderheiten und bildgebende Merkmale weniger bekannt. In den heutigen Zeiten von Migration und weltweiter Flüchtlingsströme ist die Kenntnis parasitärer Infektionen zunehmend von Bedeutung. Anhand von klinischen Beschreibungen der Echinokokkose, Schistosomiasis, Fasciolosis und Ascariasis wurden entsprechende Berichte in der Zeitschrift für Gastroenterologie publiziert. In der hier präsentierten Veröffentlichung werden klinische Besonderheiten und Bildgebung...
Source: Zeitschrift fur Gastroenterologie - March 1, 2019 Category: Gastroenterology Authors: Dietrich CF, Cretu CM, Atkinson NSS, Lee WJ, Richter J, Cui XW, Sparchez Z, Dong Y Tags: Z Gastroenterol Source Type: research

[A gut-brain neural circuit for nutrient sensory transduction].
PMID: 30861558 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - March 1, 2019 Category: Gastroenterology Authors: Reinshagen M Tags: Z Gastroenterol Source Type: research

S3-Leitlinie – Diagnostik und Therapie der Plattenepithelkarzinome und Adenokarzinome des Ösophagus.
S3-Leitlinie – Diagnostik und Therapie der Plattenepithelkarzinome und Adenokarzinome des Ösophagus. Z Gastroenterol. 2019 Mar;57(3):336-418 Authors: Porschen R, Fischbach W, Gockel I, Hollerbach S, Hölscher A, Jansen PL, Miehlke S, Pech O, Stahl M, Thuss-Patience P, Vanhoefer U, und die Mitarbeiter der Leitlinienkommission PMID: 30861559 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - March 1, 2019 Category: Gastroenterology Authors: Porschen R, Fischbach W, Gockel I, Hollerbach S, Hölscher A, Jansen PL, Miehlke S, Pech O, Stahl M, Thuss-Patience P, Vanhoefer U, und die Mitarbeiter der Leitlinienkommission Tags: Z Gastroenterol Source Type: research

Transhepatic forceps biopsy after PTCD for histological assessment of bile duct stenoses or occlusions.
CONCLUSION:  Despite good feasibility, low peri- and post-interv. risk and high validity the forceps biopsy via PTCD is not widely used. For experienced interventionalists, it is an effective method for obtaining histology. PMID: 30754057 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - February 1, 2019 Category: Gastroenterology Authors: Warnken EM, Uder M, Stein H, Wucherer M, Lell M, Muschweck H, Adamus R Tags: Z Gastroenterol Source Type: research

Risk factors for remaining liver injury in patients with virological elimination of chronic hepatitis C.
CONCLUSIONS:  Male sex, advanced liver fibrosis, and obesity are main risk factors for the lack of ALT normalization and/or ALT decline after SVR, indicative of fatty liver disease as a relevant comorbidity in hepatitis C. PMID: 30754058 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - February 1, 2019 Category: Gastroenterology Authors: Mauss S, Buendgens L, Christensen S, Ingiliz P, Berger F, Hüppe D, Simon KG, Lutz T, Schewe K, Boesecke C, Tacke F Tags: Z Gastroenterol Source Type: research

[Implementation of ultrasound education in the medical degree curriculum - the Ulm model].
fie Abstract Ultrasound is the most commonly used diagnostic method in everyday clinical practice aside from conventional radiography. For prospective physicians, there is a gap between the increased requirements in everyday clinical practice and the skills acquired thus far, especially when dealing with sonography. In this work, we would like to present the structure of our sonography course and its implementation in the Ulm core curriculum of medical studies. The sonography course is based on two pillars. The Sonography Seminar (Pillar 1) has a lecturer who regularly conveys interdisciplinary theoretical content...
Source: Zeitschrift fur Gastroenterologie - February 1, 2019 Category: Gastroenterology Authors: Pfahler M, Baumann S, Schuhbaur J, Kratzer W, für die Dozenten im Kerncurriculum Sonografie Tags: Z Gastroenterol Source Type: research

Eosinophilic esophagitis and achalasia - just a coincidence?
CONCLUSION:  The results suggest that the patient had primary EA associated with eosinophilic infiltration and that the combined occurrence of these rare diseases is not just a coincidence. PMID: 30754060 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - February 1, 2019 Category: Gastroenterology Authors: Frieling T, Heise J, Kreysel C, Blank M, Hemmerlein B, Beccu L, Kuhlbusch-Zicklam R Tags: Z Gastroenterol Source Type: research

[Perforation as a delayed complication after endoscopic full-thickness resection in a recurrent adenoma of the sigmoid].
We report the case of a 55-year old woman who underwent an endoscopic full-thickness resection with the FTRD® due to a recurrent adenoma with high-grade intraepithelial neoplasm in the sigmoid. After primary uncomplicated development, she presented with a secondary perforation with purulent peritonitis seven days after intervention, so a sigmoid-resection was necessary. There were no signs of defects with the FTRD® system or patient-related predisposed parameters, which prefer a perforation.Our case-report demonstrates the necessity for clinical follow up, after primary uncomplicated endoscopic full-thickness resec...
Source: Zeitschrift fur Gastroenterologie - February 1, 2019 Category: Gastroenterology Authors: Hürtgen SM, Schmitz G, Junge K, Breuer E, Tischendorf JJW Tags: Z Gastroenterol Source Type: research

[Do NAFLD-patients require HCC screening?]
PMID: 30754062 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - February 1, 2019 Category: Gastroenterology Authors: Karlas T, Wiegand J, Petroff D Tags: Z Gastroenterol Source Type: research

Updated S3-Guideline Ulcerative Colitis. German Society for Digestive and Metabolic Diseases (DGVS).
Abstract This guideline provides evidence-based key recommendations for diagnosis and treatment of ulcerative colitis and upgrades the 2011 version. The guideline was developed by an interdisciplinary team of gastroenterologists, surgeons, pathologists, nutrition experts, and patient support groups under the auspice of the German Society for Gastroenterology and Metabolic Diseases. The guideline used structural S3 consensus-based methodology and includes statements on clinical practice, prevention, infectiological problems, surgery and nutrition. PMID: 30654406 [PubMed - as supplied by publisher] (Source: Zei...
Source: Zeitschrift fur Gastroenterologie - January 17, 2019 Category: Gastroenterology Authors: Authors, Collaborators: Tags: Z Gastroenterol Source Type: research

Gasl 2019.
GASL 2019. Z Gastroenterol. 2019 Jan;57(1):25-26 Authors: Bartenschlager R PMID: 30641599 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - January 1, 2019 Category: Gastroenterology Authors: Bartenschlager R Tags: Z Gastroenterol Source Type: research

[4 years of direct-acting antivirals (DAAs) in the German Hepatitis C-Registry (DHC-R)].
MP, Wedemeyer H Abstract BACKGROUND:  More than 250 000 patients suffer from chronic hepatitis C in Germany. Several potent, direct-acting antiviral drugs have been approved since 2014. The aim of the German Hepatitis C-Registry (DHC-R) is to describe the epidemiology and patient care of hepatitis C and to investigate the efficacy and safety of new treatment options in real-world settings. METHODS:  The DHC-R is a prospective multicenter non-interventional registry study that includes 327 centers throughout Germany. All approved treatment options have been documented. The current analysis differen...
Source: Zeitschrift fur Gastroenterologie - January 1, 2019 Category: Gastroenterology Authors: Hüppe D, Serfert Y, Buggisch P, Mauss S, Böker KHW, Müller T, Klinker H, Günther R, Berg T, Cornberg M, Niederau C, Sarrazin C, Simon KG, Zeuzem S, Manns MP, Wedemeyer H Tags: Z Gastroenterol Source Type: research

[The role of Cytochrom P4502E1 in Alcoholic Liver Disease and alcohol mediated carcinogenesis].
Abstract Various factors are involved in the pathogenesis of alcoholic liver disease (ALD) and ethanol-mediated carcinogenesis. In addition to genetic, epigenetic and immunologic mechanisms, acetaldehyde-associated toxicity, oxidative stress as well as cytokine-mediated inflammation are of major importance. Oxidative stress, with the generation of reactive oxygen species (ROS), develops either in inflammation (alcoholic hepatitis) or during oxidation of ethanol via cytochrome P4502E1 (CYP2E1). CYP2E1 is induced by ethanol, oxidizes ethanol to acetaldehyde, and generates ROS during this process. ROS results in prot...
Source: Zeitschrift fur Gastroenterologie - January 1, 2019 Category: Gastroenterology Authors: Seitz HK, Mueller S Tags: Z Gastroenterol Source Type: research

[Hepatocellular carcinoma in an inflammatory adenoma with β-catenin mutation in a patient with hepatocellular adenomatosis due to germline mutation in HNF1α].
We report a case of a 28-year-old man with HNF1α-inactivated adenomatosis who developed an inflammatory adenoma with β catenin mutation with malignant transformation into a well-differentiated hepatocellular carcinoma (HCC). PMID: 30641602 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - January 1, 2019 Category: Gastroenterology Authors: Ridder DA, Duret D, Wörns MA, Schotten S, Heinrich S, Kloth M, Springer E, Roth W, Straub BK Tags: Z Gastroenterol Source Type: research

[Spindle and giant cell type undifferentiated carcinoma of the distal bile duct: a case report].
We report on an extremely rare case of a spindle and giant cell type undifferentiated carcinoma of the distal bile duct. In the presented tumor, atypical glands and single-cell clusters arising from the bile duct epithelium gradually transitioned into a predominantly sarcomatoid architecture, which constituted more than 98 % of the whole tumor volume. Focally, osteoclast-like giant cells were intermixed with the spindle cells. The tumor showed a high proliferation activity (Ki-67) and was demonstrated to harbor mutations in the genes for cyclin D3 (CCND3), fibroblast growth factor receptor 4 (FGFR4), neurofibromin 1 (NF1...
Source: Zeitschrift fur Gastroenterologie - January 1, 2019 Category: Gastroenterology Authors: Albrecht T, Mehrabi A, Strobel O, Vogel MN, Stenzinger A, Bergmann F, Schirmacher P, Goeppert B Tags: Z Gastroenterol Source Type: research

Case report: a rare cause of a hypervascular nodule in a noncirrhotic liver.
fmann K Abstract A 37-year-old male patient with Crohn's disease and multiple liver hemangiomas was referred to our hospital for an atypical hypervascular hepatic lesion detected on an external magnetic resonance imaging (MRI) scan. The patient was otherwise well and had no history of any liver disease. Liver values and tumor markers were normal. Contrast-enhanced ultrasound confirmed multiple hemangiomas in different liver segments and a hypervascular tumor with a hypovascular rim in segment II/IV. Repeat MRI showed a strongly enhancing neoplasm of 2.6 cm with a texture distinctly different from the otherwise r...
Source: Zeitschrift fur Gastroenterologie - January 1, 2019 Category: Gastroenterology Authors: Koschny R, Allgäuer M, Pfeiffenberger J, Seessle J, Fuchs J, Longerich T, Wielpütz MO, Hoffmann K Tags: Z Gastroenterol Source Type: research

Towards curative therapy of chronic viral hepatitis.
Abstract Persistent infection with hepatitis viruses is a major medical burden that unfortunately is often ignored in the general public. This results in a massive under-diagnosis of these infections. According to the world health organization, the number of people dying every year from the consequence of hepatitis virus infection has surpassed the death rate caused by malaria and HIV and is equivalent to the one of tuberculosis. These numbers call for more intense efforts to devise more effective, ideally curative therapies that must become as widely accessible as they are e. g. for HIV infected individuals. A ...
Source: Zeitschrift fur Gastroenterologie - January 1, 2019 Category: Gastroenterology Authors: Bartenschlager R, Urban S, Protzer U Tags: Z Gastroenterol Source Type: research

Success of immune checkpoint blockade therapies - mechanisms and implications for hepatology.
Abstract The success of immune modulation by checkpoint blockade approaches is currently transforming oncology, with high and long-lasting tumor responses in patients with advanced disease across many cancer entities. Rooted in the reinvigoration of adaptive antitumor immune responses through disinhibition of negative feedback pathways, these approaches are particularly effective in patients with significant preexisting T cell responses in tumors with high neoantigen load. While promising data is starting to emerge from clinical trials in liver cancer patients, the underlying immunobiology remains poorly understoo...
Source: Zeitschrift fur Gastroenterologie - January 1, 2019 Category: Gastroenterology Authors: Bengsch B, Thimme R Tags: Z Gastroenterol Source Type: research

Vielen Dank!
Authors: PMID: 30536251 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - December 1, 2018 Category: Gastroenterology Tags: Z Gastroenterol Source Type: research

Hyperplastic polyps and nonadvanced adenomas, but not advanced polypoid lesions, are detected more frequently in the presence of colonic diverticula during screening colonoscopies.
HM Abstract HINTERGRUND:  Die bisher veröffentlichte Studienlage zur Assoziation von Kolondivertikeln und kolorektalen Polypen einschließlich des kolorektalen Karzinoms (KRK) ist konträr. Ziel der Studie war es, die Assoziation für sämtliche relevanten histologischen Polypensubtypen, d. h. hyperplastische Polypen (HP), sessil und traditionell serratierte Adenome (SSA und TSA), klinisch relevante serratierte Polypen (krSP), tubuläre Adenome und fortgeschrittene Adenome in einer ausschließlichen Vorsorgekoloskopie-Kohorte zu untersuchen. MATERIAL UND METHODEN:  ...
Source: Zeitschrift fur Gastroenterologie - December 1, 2018 Category: Gastroenterology Authors: Schramm C, Kütting F, Lang S, Kasper P, Chon SH, Steffen HM Tags: Z Gastroenterol Source Type: research

Clinical evaluation of the M-ANNHEIM classification: Development of  the M-ANNHEIM-Surgery-Score as a new tool to monitor patients with chronic pancreatitis.
Clinical evaluation of the M-ANNHEIM classification: Development of the M-ANNHEIM-Surgery-Score as a new tool to monitor patients with chronic pancreatitis. Z Gastroenterol. 2018 Dec;56(12):1481-1490 Authors: Hirth M, Weiss C, Rückert F, Pfützer RH, Wilhelm TJ, Hetjens S, Hardt PD, Gubergrits N, Ebert MP, Schneider A Abstract OBJECTIVES:  The M-ANNHEIM classification of chronic pancreatitis (CP) stratifies degrees of disease severity according to the M-ANNHEIM-Severity-Score. We aimed to demonstrate the clinical usefulness of the M-ANNHEIM-Severity-Score in quantifying and predicti...
Source: Zeitschrift fur Gastroenterologie - December 1, 2018 Category: Gastroenterology Authors: Hirth M, Weiss C, Rückert F, Pfützer RH, Wilhelm TJ, Hetjens S, Hardt PD, Gubergrits N, Ebert MP, Schneider A Tags: Z Gastroenterol Source Type: research

Comparison of the quality of B-scan ultrasound in modern high-end devices.
CONCLUSION:  There are relevant differences in the quality of the B-scan mode of modern high-end devices. The suggested retail prices do not correlate with the B-scan quality of the ultrasound devices. PMID: 30536254 [PubMed - in process] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - December 1, 2018 Category: Gastroenterology Authors: Merkel D, Stahlheber H, Chupina V, Schneider C Tags: Z Gastroenterol Source Type: research

[Chronic granulomatous disease as a rare differential diagnosis of inflammatory bowel disease].
We present the case of a 28-year old patient who has been diagnosed with IBD at the age of 2 years. He showed recurrent liver abscesses and the picture of a chronic IBD. METHODS:  Clinical and laboratory data was obtained and endoscopic, radiologic and histologic examinations, tests for granulocytic functions as well as a genetic analysis were performed. Literature of the PubMed database and recent literature were analyzed. CASE:  Under immunosuppressive therapy, with TNF -blocker Adalimumab followed by therapy with integrin-receptor antagonist Vedolizumab, the patient developed recurrent abscesses of t...
Source: Zeitschrift fur Gastroenterologie - November 22, 2018 Category: Gastroenterology Authors: Metzger JC, Kurz E, von Spee-Mayer C, Kolck G, Bogumil A, Galle PR, Zimmermann T Tags: Z Gastroenterol Source Type: research

Colorectal cancer stage at diagnosis in migrants and non-migrants: a  cross-sectional analysis of the KoMigra Study in Germany.
CONCLUSIONS:  Migration background was not significantly associated with advanced tumour stage at diagnosis. However, the effect of poor language proficiency should be explored further. PMID: 30466134 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - November 22, 2018 Category: Gastroenterology Authors: Dahlhaus A, Siebenhofer A, Guethlin C, Taubenroth M, Albay Z, Schulz-Rothe S, Singer S, Plath J Tags: Z Gastroenterol Source Type: research

Never seen before? Opisthorchiasis and Clonorchiasis.
Abstract Parasitic diseases are relatively rarely diagnosed and treated in Europe. Therefore, European clinicians are not familiar with their clinical and imaging features. In an era of increased human migration, it is fundamental for clinicians to be able to identify such diseases. We have recently described the features of cystic echinococcosis, schistosomiasis, fascioliasis and ascariasis. Here, we report on the clinical and imaging features as well as on the current therapy options of infections by the small liver flukes: Clonorchis sinensis, Opisthorchis viverrini (Southeast Asian liver fluke) and Opisthorchi...
Source: Zeitschrift fur Gastroenterologie - November 22, 2018 Category: Gastroenterology Authors: Dietrich CF, Atkinson NSS, Lee WJ, Kling K, Neumayr A, Braden B, Richter J, Akpata R, Southisavath P, Schreiber-Dietrich D, Dong Y Tags: Z Gastroenterol Source Type: research

[Endoscopic submucosal dissection for mucosal low-risk early gastric cancer - a retrospective, unicentric study].
CONCLUSION:  In the low-risk group that we defined, a high rate of en bloc and R0 resections were achieved with ESD; the detected local recurrences could be treated endoscopically. Metastases were not detected, no tumor-associated patient deaths occured. ESD is, therefore, recommended for this group as a standard therapy. The study provides no data on the endoscopic and clinical follow up in the presence of risk factors of both mucosal and other EGCs from the so-called Expanded Group (including lymphangio-invasion, submucosal invasive EGC, poorly differentiated G3 carcinomas). PMID: 30419578 [PubMed - in process]...
Source: Zeitschrift fur Gastroenterologie - November 1, 2018 Category: Gastroenterology Authors: Scheerer F, Schmitt W, Dollhopf M, Kremer M Tags: Z Gastroenterol Source Type: research