Sperm DNA methylation changes after short ‐term nut supplementation in healthy males consuming a Western‐style diet
ConclusionAdding nuts to a regular Western ‐style diet subtly impacts sperm DNA methylation in specific regions, demonstrating that there are some sperm epigenome regions that could respond to diet. (Source: Andrology)
Source: Andrology - September 23, 2020 Category: Urology & Nephrology Authors: Albert Salas ‐Huetos, Emma R. James, Jordi Salas‐Salvadó, Mònica Bulló, Kenneth I. Aston, Douglas T. Carrell, Timothy G. Jenkins Tags: ORIGINAL ARTICLE Source Type: research

European Acedemy of Andrology (EAA) GUIDELINES ON KLINEFELTER SYNDROME ‐ Endorsing Organisation: European Society of Endocrinology
ConclusionThese guidelines provide recommendations and suggestions to care for patients with KS in various developmental stages ranging from childhood and adolescence to adulthood. This advice is based on recent research data and respective evaluations as well as validations performed by a group of experts. (Source: Andrology)
Source: Andrology - September 22, 2020 Category: Urology & Nephrology Authors: Michael Zitzmann, Lise Aksglaede, Giovanni Corona, Andrea M. Isidori, Anders Juul, Guy T'Sjoen, Sabine Kliesch, Kathleen D'Hauwers, Jorma Toppari, Jolanta S łowikowska‐Hilczer, Frank Tüttelmann, Alberto Ferlin Tags: REVIEW ARTICLE Source Type: research

Fertility outcomes and predictors for successful sperm retrieval and pregnancy in 327 azoospermic men with a history of cryptorchidism who underwent microdissection testicular sperm extraction
AbstractBackgroundAlthough few studies have reported fertility outcomes, no study has reported risk factors that might predict sperm retrieval and pregnancy in azoospermic men with a history of cryptorchidism in a large series.ObjectivesTo investigate fertility outcomes and predictors for successful sperm retrieval and pregnancy in azoospermic men with a history of cryptorchidism who underwent microdissection testicular sperm extraction (mTESE).Materials and MethodsThis retrospective observational study included 327 azoospermic men with a history of cryptorchidism who underwent mTESE. Fertility outcomes including sperm ret...
Source: Andrology - September 22, 2020 Category: Urology & Nephrology Authors: Selahittin Çayan, İrfan Orhan, Barış Altay, Ramazan Aşcı, Erdem Akbay, Bülent Ayas, Önder Yaman Tags: ORIGINAL ARTICLE Source Type: research

Coronavirus: A Possible Cause of Reduced Male Fertility
AbstractIn lately December 2019, a novel coronavirus (SARS ‐CoV‐2) outbreak occurred in Wuhan, PR China. It is a high contagious virus that has threatened human health worldwide. SARS‐CoV‐2 infection, termed COVID‐19, causes rapidly developing lung lesions that can lead to multiple organ failure in a short period. Whenever a novel virus emerges , reproductive risk assessments should be performed after infection. In this review, we show that male fertility might be damaged by coronavirus associated with (i) direct cytopathic effects derived from viral replication and viral dissemination in the testi...
Source: Andrology - September 22, 2020 Category: Urology & Nephrology Authors: Chuan Huang, Xiren Ji, Wenjun Zhou, Zhenghui Huang, Xiangjie Peng, Liqing Fan, Ge Lin, Wenbing Zhu Tags: REVIEW ARTICLE Source Type: research

Relationship Between Male Age, Semen Parameters and Assisted Reproductive Technology Outcomes
AbstractBackgroundLow semen quality often obligates the use of assisted reproductive technology (ART); however, the association between semen quality and ART outcomes is uncertain.ObjectivesTo further assess the impact of semen quality on ART outcomes.Materials and MethodsA retrospective cohort study was carried out at a single academic reproductive medicine center (January 2012 ‐December 2018). Patients undergoing at least one ART cycle utilizing freshly ejaculated sperm from the male partner were included. We assessed the association between semen quality (as stratified based on WHO 5th edition criteria), paternal age (
Source: Andrology - September 22, 2020 Category: Urology & Nephrology Authors: Alex M. Kasman, Shufeng Li, Qianying Zhao, Barry Behr, Michael L. Eisenberg Tags: ORIGINAL ARTICLE Source Type: research

Morphologic alterations of the genital mesentery implicated in testis nondescent in rats prenatally exposed to flutamide
ConclusionOur findings showed a combined contribution of both cranial and caudal folds of the genital mesentery to testis nondescent, through an abnormally long mesentery root and an abnormally short gubernacular ligament, respectively. Inhibition of male ‐specific development of the genital mesentery with flutamide did not result in a feminized architecture. (Source: Andrology)
Source: Andrology - September 18, 2020 Category: Urology & Nephrology Authors: Anastasia Mentessidou, Christos Salakos, George Chrousos, Christina Kanaka ‐Gantenbein, Alkiviadis Kostakis, Petros Mirilas Tags: ORIGINAL ARTICLE Source Type: research

De novo mutations in idiopathic male infertility —A pilot study
AbstractStudy questionAre de novo mutations in the human genome associated with male infertility?Summary answerWe identified de novo mutations in five candidate genes:SEMA5A,NEURL4,BRD2, CD1D, andCD63.What is known alreadyEpidemiological and genetic studies have consistently indicated contribution of genetic factors to the etiology of male infertility, suggesting that more than 1500 genes are involved in spermatogenesis.Study design, size, durationFirst, we searched for de novo mutations in patients with idiopathic azoospermia with whole ‐exome sequencing (WES). To evaluate the potential functional impact of de novo iden...
Source: Andrology - September 17, 2020 Category: Urology & Nephrology Authors: Alenka Hod žić, Aleš Maver, Dijana Plaseska‐Karanfilska, Momčilo Ristanović, Predrag Noveski, Branko Zorn, Marija Terzic, Tanja Kunej, Borut Peterlin Tags: ORIGINAL ARTICLE Source Type: research

Triglyceride ‐Glucose Index (TyG) is associated with erectile dysfunction : A cross sectional study
AbstractBackgroundErectile dysfunction (ED) is  often associated with endocrine metabolic diseases such as metabolic syndrome (MetS) and diabetes mellitus (DM), in which insulin resistance (IR) plays a decisive role in pathology. Triglyceride‐glucose index (TyG), a simple, inexpensive and easily accessible IR marker, is calculated by fasti ng serum glucose and triglyceride values.ObjectivesWe aimed  to reveal the relationship between TyG index and ED.Materials And Methods152  male patients, aged between 24‐80 years, admitted to the urology outpatient clinic&nb...
Source: Andrology - September 16, 2020 Category: Urology & Nephrology Authors: Mehmet Yilmaz, Mustafa Karaaslan, Senol Tonyali, Mecit Celik, Tuncay Toprak, Oner Odabas Tags: ORIGINAL ARTICLE Source Type: research

Epididymal and ejaculated sperm functionality is regulated differently by periovulatory oviductal fluid (pOF) in pigs
ConclusionThe modulation of sperm functionality by pOF is conditioned by the origin of the spermatozoa. (Source: Andrology)
Source: Andrology - September 13, 2020 Category: Urology & Nephrology Authors: Cristina Soriano ‐Úbeda, Karen Avilés‐López, Francisco A. García‐Vázquez, Jon Romero‐Aguirregomezcorta, Carmen Matás Tags: ORIGINAL ARTICLE Source Type: research

Defining the impact of peyronie ’s disease on the psychosocial status of gay men
We described demographics and sexual variables by sexual orientation. We then compared PDQ items and summary scores by sexual orientation, using a series of independent samples t‐tests.Results34 consecutive gay and 464 straight men were included. Age and baseline characteristics were similar between the two cohorts, with the exception that fewer gay men were partnered (56% vs 87%, p
Source: Andrology - September 10, 2020 Category: Urology & Nephrology Authors: Carolyn A. Salter, Bruno Nascimento, Jean ‐Etienne Terrier, Hisanori Taniguchi, Helen Bernie, Eduardo Miranda, Lawrence Jenkins, Elizabeth Schofield, John P. Mulhall Tags: ORIGINAL ARTICLE Source Type: research

Reflections on The T Trials
ConclusionsThe T Trials studied the efficacy of testosterone replacement therapy on 788 men with low testosterone and symptoms of hypogonadism. The studies demonstrated benefits in four trials (sexual function, vitality, bone and anemia); partial benefit in the physical function trial; no effect in the cognition trial; and a negative effect in the exploratory cardiovascular trial. The T Trials were not designed to assess long ‐term risks of testosterone in men (Source: Andrology)
Source: Andrology - September 9, 2020 Category: Urology & Nephrology Authors: Ronald Swerdloff, Christina Wang Tags: REVIEW ARTICLE Source Type: research

Novel hydrogen ‐producing Si‐based agent reduces oxidative stress, and improves sperm motility and in vitro fertilization rate in varicocoele
This study aimed to investigate the therapeutic effects of oral administration of a Si ‐based agent on varicocoele rat.Materials and methodsTwenty ‐one rats were divided into four groups: varicocoele + normal diet (n = 5), varicocoele + Si‐based agent‐supplemented diet (n = 6), sham + normal diet (n = 5), and sham + Si‐based agent‐supplemented diet (n = 5). All rats were euthanized four weeks after surgery.ResultsThe mean left epididymal sperm motility was 74.4% in the sham group, 72.3% in the sham + Si group, 57.6% in the varicocoe...
Source: Andrology - September 9, 2020 Category: Urology & Nephrology Authors: Yusuke Inagaki, Shinichiro Fukuhara, Ryoichi Imamura, Yuki Kobayashi, Sohei Kuribayashi, Koichi Okada, Yosuke Sekii, Kentaro Takezawa, Hiroshi Kiuchi, Motohide Uemura, Hikaru Kobayashi, Norio Nonomura Tags: ORIGINAL ARTICLE Source Type: research

GC ‐MS‐based metabolic signatures reveal comparative steroidogenic pathways between fetal and adult mouse testes
AbstractBackgroundPrevious studies on gonadal steroidogenesis have not compared metabolic pathways between fetal and adult mouse testes to date.ObjectivesTo evaluate comparative metabolic signatures of testicular steroids between fetus and adult mice using gas chromatography ‐mass spectrometry (GC‐MS)‐based steroid profiling.Materials and methodsGC ‐MS with molecular‐specific scan modes was optimized for selective and sensitive detection of 23 androgens, 7 estrogens, 14 progestogens, and 13 corticoids from mouse testes with a quantification limit of 0.1‐5.0 ng/mL and reproducibility (coefficient of variati...
Source: Andrology - September 9, 2020 Category: Urology & Nephrology Authors: Soyun Han, Takashi Baba, Shogo Yanai, Dong Jun Byun, Ken ‐ichirou Morohashi, Jae‐Hong Kim, Man Ho Choi Tags: ORIGINAL ARTICLE Source Type: research

Variables affecting long ‐term usage rate of sperm samples cryopreserved for fertility preservation in cancer patients
ConclusionThe usage rate of frozen sperm in cancer patient is low, even extending the duration of follow ‐up. (Source: Andrology)
Source: Andrology - September 9, 2020 Category: Urology & Nephrology Authors: Stefania Ferrari, Alessio Paffoni, Marco Reschini, Stefania Noli, Chiara Dallagiovanna, Cristina Guarneri, Francesca Filippi, Edgardo Somigliana Tags: ORIGINAL ARTICLE Source Type: research

Venlafaxine ‐induced damage to seminiferous epithelium, spermiation, and sperm parameters in rats: A correlation with high estrogen levels
ConclusionVenlafaxine increases testosterone aromatization and Cx43. This drug, via high estrogen levels, disturbs Sertoli cells, induces germ cell death, and impairs spermiation and sperm parameters. The restoration of spermiation associated with the decreased Cx43 and hormonal levels in venlafaxine ‐65 days reinforces that high estrogen levels are related to venlafaxine‐induced changes. The presence of damaged Sertoli cells, germ cell death, and low sperm motility in venlafaxine‐65 days indicates that interruption of treatment for 30 days was insufficient for testicular recovery and p oints to a long...
Source: Andrology - September 9, 2020 Category: Urology & Nephrology Authors: Fabiane Santi, Fl ávia L. Beltrame, Beatriz M. Rogridues, Marcio J. V. P. Junior, Natália F. Scaramele, Flávia L. Lopes, Paulo S. Cerri, Estela Sasso‐Cerri Tags: ORIGINAL ARTICLE Source Type: research

Unraveling how in vitro capacitation alters ram sperm chromatin before and after cryopreservation
This study aimed to investigate dynamic modifications produced in the chromatin structure of ram spermatozoa duringin vitro capacitation before and after cryopreservation.Materials and methodsChromatin decondensation (AB+), DNA methylation, DNA fragmentation index (%DFI) and high DNA stainability (HDS) were evaluated in fresh and frozen ‐thawed ram spermatozoa incubated under capacitating (CAP) conditions at 1, 5, 15, 30, 60, 120, 180 and 240 min and under non‐capacitating (NC) conditions at 0, 15 and 240 min.ResultsIncubation in NC conditions did not induce significant changes in chromatin condensation (P> 0.05; AB...
Source: Andrology - September 4, 2020 Category: Urology & Nephrology Authors: Patricia Peris ‐Frau, Manuel Álvarez‐Rodríguez, Alicia Martín‐Maestro, María Iniesta‐Cuerda, Irene Sánchez‐Ajofrín, Daniela Alejandra Medina‐Chávez, José Julián Garde, Margarita Villar, Heriberto Rodriguez‐Martinez, Ana Jos Tags: ORIGINAL ARTICLE Source Type: research

Long ‐term effect of gender‐affirming hormone treatment on depression and anxiety symptoms in transgender people: A prospective cohort study
AbstractBackgroundCross ‐sectional studies show that transgender people are more likely than cisgender people to experience depression and anxiety before gender‐affirming hormone treatment (GAHT). However, the effect of GAHT on mental health in transgender people, and the role of other factors that may have a predictiv e effect, is poorly explored.ObjectivesUsing a longitudinal methodology, this study investigated the effect of 18 ‐month GAHT on depression and anxiety symptomatology and the predictors on mental health outcomes in a large population of transgender people.Materials and methodsParticipants (n  =&nb...
Source: Andrology - September 3, 2020 Category: Urology & Nephrology Authors: Zo ë Aldridge, Shireen Patel, Boliang Guo, Elena Nixon, Walter Pierre Bouman, Gemma L. Witcomb, Jon Arcelus Tags: ORIGINAL ARTICLE Source Type: research

Effect of Neurovascular Bundle Sparing Radical Cystectomy on Postoperative Continence and Sexual Function: A Systematic Review and Meta ‐Analysis
AbstractBackgroundIt is unclear whether the neurovascular bundle (NVB) sparing could improve postoperative urinary continence and potency. Furthermore, concern remains regarding the impact of nerve sparing (NS) radical cystectomy (RC) on oncological outcomes.ObjectivesThe primary objective of this meta ‐analysis is to evaluate if in men undergoing NS RC could improve postoperative urinary continence and potency. The secondary objective is to assess if NS RC could compromise the oncological control.Materials and methodsA systematic search of the Pubmed and Web of Science was performed in February 2020, yielding 1446 uniqu...
Source: Andrology - September 2, 2020 Category: Urology & Nephrology Authors: Xingyu Xiong, Shi Qiu, Xianyanling Yi, Kun Jin, Hang Xu, Hanran Lei, Shengjiang Bai, Ge Peng, Lu Yang, Qiang Wei Tags: ORIGINAL ARTICLE Source Type: research

SARS ‐CoV‐2 and its relationship with the genitourinary tract: implications for male reproductive health in the context of COVID‐19 pandemic
ABSTRACTThe current outbreak of coronavirus ‐associated (CoVs) acute respiratory disease, named coronavirus disease 19 (COVID‐19), is not the first well‐known spillover of an animal originated virus to infect humans. However, it is one of the few to make such a fast jump in a powerful and efficient evolutionary shortcut. The incredible pattern of aggressiveness and the nude reality all over the world since the beginning of the outbreak is that 15 to 20% of those infected need hospitalization because of adverse clinical scenarios, and 5% evolve to critical conditions, not limited to respiratory‐related issues, but r...
Source: Andrology - September 1, 2020 Category: Urology & Nephrology Authors: Jorge Hallak, Thiago A. Teixeira, Felipe S. Bernardes, Felipe Carneiro, Sergio A.C. Duarte, Juliana Risso Pariz, Sandro C Esteves Tags: REVIEW ARTICLE Source Type: research

Effects of platelet ‐rich plasma on spermatogenesis and hormone production in an experimental testicular torsion model
Discussion and conclusionThe PRP has beneficial effects on spermatogenesis and reproductive hormone production in testicular torsion. It is easily accessible and applicable. In the future intratesticular PRP injection may be used in testicular torsion after detorsion However, further experimental and large ‐scale, prospective clinical studies are needed to establish a definitive conclusion on this topic. (Source: Andrology)
Source: Andrology - August 31, 2020 Category: Urology & Nephrology Authors: Musab Ali Kutluhan, Emrah Özsoy, Aytaç Şahin, Ahmet Ürkmez, Ramazan Topaktaş, Tuncay Toprak, Gülistan Gümrükçü, Ayhan Verit Tags: ORIGINAL ARTICLE Source Type: research

Metabolomic signature of the seminal plasma in men with severe oligoasthenospermia
AbstractBackgroundMale factor is incriminated in approximately 50% of cases of infertility. The metabolomic approach has recently been used in the assessment of sperm quality and male fertility.Materials and methodsWe analyzed the metabolomic signatures of the seminal plasma in 20 men with severe oligoasthenospermia (prewash total motile sperm count  
Source: Andrology - August 31, 2020 Category: Urology & Nephrology Authors: Magalie Boguenet, Cinzia Bocca, Pierre ‐Emmanuel Bouet, Orianne Serri, Stéphanie Chupin, Lydie Tessier, Odile Blanchet, Hady El Hachem, Juan Manuel Chao de la Barca, Pascal Reynier, Pascale May‐Panloup Tags: ORIGINAL ARTICLE Source Type: research

Retrograde ejaculation after holmium laser enucleation of the prostate (HoLEP) —Impact on sexual function and evaluation of patient bother using validated questionnaires
AbstractBackgroundA vast body of literature has focused on erectile function after Holmium Laser Enucleation of the Prostate (HoLEP). Interestingly, retrograde ejaculation (RE), despite its frequency has sparsely been investigated.ObjectivesTo study patient perception and impact of RE on sexuality following HoLEP.Materials and methodsWe retrospectively analyzed 2,131 patients undergoing HoLEP 2006 ‐2015 at our institution. Patients were followed via standardized questionnaires namely International Index of Erectile Function (IIEF) as well as Male Sexual Health Questionnaire Ejaculatory Short Form (MSHQ‐EjD‐SF). Exclu...
Source: Andrology - August 31, 2020 Category: Urology & Nephrology Authors: Philipp Gild, Roland Dahlem, Raisa S. Pompe, Armin Soave, Malte W. Vetterlein, Tim A. Ludwig, Valentin Maurer, Phillip Marks, Sascha A. Ahyai, Felix K. ‐H. Chun, Lukas Lenke, Tabea Ernst, Margit Fisch, Michael Rink, Christian P. Meyer, An Tags: ORIGINAL ARTICLE Source Type: research

De novo mutations in idiopathic male infertility ‐ a pilot study
AbstractStudy questionAre de novo mutations in the human genome associated with male infertility?Summary answerWe identified de novo mutations in five candidate genes: SEMA5A, NEURL4, BRD2, CD1D, and CD63.What is known alreadyEpidemiological and genetic studies have consistently indicated contribution of genetic factors to the etiology of male infertility, suggesting that more than 1500 genes are involved in spermatogenesis.Study design, size, durationFirst we searched for de novo mutations in patients with idiopathic azoospermia with whole exome sequencing (WES). To evaluate the potential functional impact of de novo iden...
Source: Andrology - August 29, 2020 Category: Urology & Nephrology Authors: A. Hod žić, A. Maver, D. Plaseska‐Karanfilska, M. Ristanović, P. Noveski, B. Zorn, M. Terzic, T. Kunej, B. Peterlin Tags: ORIGINAL ARTICLE Source Type: research

Andrology 2020
Andrology, Volume 8, Issue 5, Page 1496-1498, September 2020. (Source: Andrology)
Source: Andrology - August 28, 2020 Category: Urology & Nephrology Tags: NEWSLETTER Source Type: research

Issue Information
Andrology, Volume 8, Issue 5, Page 965-967, September 2020. (Source: Andrology)
Source: Andrology - August 28, 2020 Category: Urology & Nephrology Tags: ISSUE INFORMATION Source Type: research

ICA advertisement
Andrology, Volume 8, Issue 5, Page 1496-1498, September 2020. (Source: Andrology)
Source: Andrology - August 28, 2020 Category: Urology & Nephrology Tags: NEWSLETTER Source Type: research

In Memoriam: Duane L. Garner, PhD
Andrology, Volume 8, Issue 5, Page 968-969, September 2020. (Source: Andrology)
Source: Andrology - August 28, 2020 Category: Urology & Nephrology Authors: Steven P. Lorton, Rupert Amann, Mel DeJarnette, Larry Johnson, Rex A. Hess Tags: IN MEMORIAM Source Type: research

Upregulated expression of NMDA receptor in the paraventricular nucleus shortens ejaculation latency in rats with experimental autoimmune prostatitis
AbstractBackgroundEstimated 30% ‐40% of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) suffer from premature ejaculation (PE), which is difficult to cure, but the mechanism is still unknown. Based on the results of our previous clinical studies and animal experiments, we propose that the glutamatergic s ystem dysfunction in the paraventricular nucleus (PVN) may be involved.MethodsTo test this hypothesis, we used experimental autoimmune prostatitis (EAP) rats to investigate the effects of CP/CPPS on ejaculation behavior through integrating copulatory behavior testing, neuroelectrophysiologic expe...
Source: Andrology - August 25, 2020 Category: Urology & Nephrology Authors: Jie Yang, Qi ‐jie Zhang, Jia‐yi Zhang, Ya‐min Wang, Guo‐qing Zhu, Ning‐hong Song, Zeng‐jun Wang, Jian‐huai Chen, Jia‐dong Xia Tags: Original Article Source Type: research

Variables affecting long term usage rate of sperm samples cryopreserved for fertility preservation in cancer patients
ConclusionThe usage rate of frozen sperm in cancer patient is low, even extending the duration of follow ‐up. (Source: Andrology)
Source: Andrology - August 19, 2020 Category: Urology & Nephrology Authors: Stefania Ferrari, Alessio Paffoni, Marco Reschini, Stefania Noli, Chiara Dallagiovanna, Cristina Guarneri, Francesca Filippi, Edgardo Somigliana Tags: ORIGINAL ARTICLE Source Type: research

GC ‐MS–based metabolic signatures reveal comparative steroidogenic pathways between fetal and adult mouse testes
ABSTRACTBackgroundPrevious studies on gonadal steroidogenesis have not compared metabolic pathways between fetal and adult mouse testes to date.ObjectivesTo evaluate comparative metabolic signatures of testicular steroids between fetus and adult mice using gas chromatography ‐mass spectrometry (GC‐MS)‐based steroid profiling.Materials and methodsGC ‐MS with molecular‐specific scan modes was optimized for selective and sensitive detection of 23 androgens, 7 estrogens, 14 progestagens, and 13 corticoids from mouse testes with a quantification limit of 0.1~5.0 ng/mL and reproducibility (coefficient of variation: 0.3...
Source: Andrology - August 18, 2020 Category: Urology & Nephrology Authors: Soyun Han, Takashi Baba, Shogo Yanai, Dong Jun Byun, Ken ‐ichirou Morohashi, Jae‐Hong Kim, Man Ho Choi Tags: ORIGINAL ARTICLE Source Type: research

Diagnostic performance of discontinuous density gradient centrifugation for estimating human semen quality
AbstractBackgroundSemen analysis plays an important role in the diagnosis of male infertility. However, many studies have demonstrated that the current methods of semen analysis are inefficient for assessing male fertility.ObjectiveTo test whether prior discontinuous density gradient centrifugation (DDCG) improves the performance of semen analysis in diagnosing male infertility.Materials and MethodsInfertile men and fertile men were recruited from the clinic. Pre ‐ and post‐DDGC values for the semen parameters of sperm concentration, total sperm number, percent total motility, percent progressive motility, percent norm...
Source: Andrology - August 17, 2020 Category: Urology & Nephrology Authors: Yanan Zhang, Juan Cheng, Jianping Ou, Zhuojie Liu, Yonghui Liu, Zhi ‐Jun Zang Tags: ORIGINAL ARTICLE Source Type: research

Resveratrol improves sperm DNA quality and reproductive capacity in type 1 diabetes
ConclusionRES attenuates lipid peroxidation and sperm DNA damage in DM1 ‐induced animals, which positively reflects on male fertility. Our results show RES potential against DM1 complications in male reproduction. (Source: Andrology)
Source: Andrology - August 17, 2020 Category: Urology & Nephrology Authors: Joana Nogu ères Simas, Talita Biude Mendes, Leonardo Wensing Fisher, Vanessa Vendramini, Sandra Maria Miraglia Tags: ORIGINAL ARTICLE Source Type: research

Novel hydrogen ‐producing Si‐based agent reduces oxidative stress, improves sperm motility and in vitro fertilization rate in varicocele
This study aimed to investigate the therapeutic effects of oral administration of a Si ‐based agent on varicocele rat.Materials and methodsTwenty ‐one rats were divided into four groups: varicocele+normal diet (n = 5), varicocele+Si‐based agent‐supplemented diet (n = 6), sham + normal diet (n = 5), and sham+Si‐based agent‐supplemented diet (n = 5). All rats were euthanized four weeks after surgery.ResultsThe mean left epididymal sperm motility was 74.4% in the sham group, 72.3% in the sham+Si group, 57.6% in the varicocele group, and 66.9% in the varicocele+Si group. Epididymal sperm motility was significantly ...
Source: Andrology - August 16, 2020 Category: Urology & Nephrology Authors: Yusuke Inagaki, Shinichiro Fukuhara, Ryoichi Imamura, Yuki Kobayashi, Sohei Kuribayashi, Koichi Okada, Yosuke Sekii, Kentaro Takezawa, Hiroshi Kiuchi, Motohide Uemura, Hikaru Kobayashi, Norio Nonomura Tags: ORIGINAL ARTICLE Source Type: research

The semen microbiome and its impact on sperm function and male fertility: A systematic review and meta ‐analysis
AbstractBackgroundMale factor is attributable in up to 50% of cases of infertility. In ‐vitro studies demonstrate that bacteria can negatively impact sperm function. The use of next‐generation sequencing (NGS) techniques have provided a better understanding of the human microbiome, and dysbiosis has been reported to impact health. Evidence regarding the impact of the semen microbi ome on sperm function and fertility remains conflicting.Materials and methodsA systematic search was conducted in accordance with the Preferred Reporting Items for Reviews and Meta ‐analysis (PRISMA) statement. The databases MEDLINE, OVID a...
Source: Andrology - August 13, 2020 Category: Urology & Nephrology Authors: L Farahani, T Tharakan, T Yap, JW Ramsay, CN Jayasena, S Minhas Tags: REVIEW ARTICLE Source Type: research

Tsga10 is essential for arrangement of mitochondrial sheath and male fertility in mice
Discussion and conclusionWe demonstrate that deficiency ofTsga10 gene can lead to male infertility in mice. TSGA10 is involved in the correct arrangement of mitochondrial sheath in sperm. Future studies on TSGA10 include an in ‐depth exploration of the underlying mechanisms of TSGA10 in spermatogenesis, early embryonic development and GnRH network. (Source: Andrology)
Source: Andrology - August 13, 2020 Category: Urology & Nephrology Authors: Geng Luo, Meiqi Hou, Bo Wang, Zhenxing Liu, Wenqiang Liu, Tiantian Han, Dazhi Zhang, Xiaopei Zhou, Weimin Jia, Yang Tan, Yanling Wu, Jiarui Wang, Xianqin Zhang Tags: ORIGINAL ARTICLE Source Type: research

Rat model and validation of a modified single ‐armed suture technique for microsurgical vasoepididymostomy: Guo’s SA‐LIVE
ConclusionsGuo ’s single‐armed suture technique is a potentially effective alternative to perform vasoepididymostomy when specialized double‐armed micro sutures are not available based on the current animal experiment. (Source: Andrology)
Source: Andrology - August 11, 2020 Category: Urology & Nephrology Authors: Yiming Yuan, Dong Fang, Hongen Lei, Meng Li, Wanjun Cheng, Bing Gao, Jing Peng, Zhichao Zhang, Zhongcheng Xin, Yinglu Guo Tags: ORIGINAL ARTICLE Source Type: research

Retrograde Ejaculation After Holmium Laser Enucleation Of The Prostate (HoLEP) – Impact On Sexual Function and Evaluation Of Patient Bother Using Validated Questionnaires
AbstractBackgroundA vast body of literature has focused on erectile function after Holmium Laser Enucleation of the Prostate (HoLEP). Interestingly, retrograde ejaculation (RE), despite its frequency has sparsely been investigated.ObjectivesTo study patient perception and impact of RE on sexuality following HoLEP.Materials and methodsWe retrospectively analyzed 2,131 patients undergoing HoLEP 2006 ‐2015 at our institution. Patients were followed via standardized questionnaires namely International Index of Erectile Function (IIEF) as well as Male Sexual Health Questionnaire Ejaculatory Short Form (MSHQ‐EjD‐SF). Exclu...
Source: Andrology - August 11, 2020 Category: Urology & Nephrology Authors: Philipp Gild, Roland Dahlem, Raisa S. Pompe, Armin Soave, Malte W. Vetterlein, Tim A. Ludwig, Valentin Maurer, Philip Marks, Sascha Ahyai, Felix K. ‐H. Chun, L Lenke, T Ernst, Margit Fisch, Michael Rink, Christian Meyer, Andreas Becker Tags: ORIGINAL ARTICLE Source Type: research

Late ‐onset hypogonadism: Reductio ad absurdum of the cardiovascular risk‐benefit of testosterone replacement therapy
ConclusionsAttempts to demonstrate that TRT damages the cardiovascular system via systematic analysis of the putative mechanisms led to the contradiction of the initial hypothesis. Current evidence indicates that TRT is safe once other comorbidities are addressed. (Source: Andrology)
Source: Andrology - August 11, 2020 Category: Urology & Nephrology Authors: Franz Sesti, Riccardo Pofi, Marianna Minnetti, Marta Tenuta, Daniele Gianfrilli, Andrea M. Isidori Tags: REVIEW ARTICLE Source Type: research

Long term effect of gender affirming hormone treatment on depression and anxiety symptoms in transgender people: A prospective cohort study
AbstractBackgroundCross ‐sectional studies show that transgender people are more likely than cisgender people to experience depression and anxiety before Gender Affirming Hormone Treatment (GAHT). However, the effect of GAHT on mental health in transgender people, and the role of other factors that may have a predictive effect, is poorly explored.ObjectivesUsing a longitudinal methodology, this study investigated the effect of 18 months GAHT on depression and anxiety symptomatology and the predictors on mental health outcomes in a large population of transgender people.Materials and MethodsParticipants (n=178) completed ...
Source: Andrology - August 10, 2020 Category: Urology & Nephrology Authors: Zo ë Aldridge, Shireen Patel, Boliang Guo, Elena Nixon, Walter Pierre Bouman, Gemma L. Witcomb, Jon Arcelus Tags: ORIGINAL ARTICLE Source Type: research

Metabolomics signature of the seminal plasma in men with severe oligoasthenospermia
AbstractBackgroundMale factor is incriminated in approximately 50% of cases of infertility. The metabolomics approach has recently been used in the assessment of sperm quality and male fertility.Materials and methodsWe analyzed the metabolomics signatures of the seminal plasma in 20 men with severe oligoasthenospermia (prewash total motile sperm count
Source: Andrology - August 8, 2020 Category: Urology & Nephrology Authors: Magalie Boguenet, Cinzia Bocca, Pierre ‐Emmanuel Bouet, Orianne Serri, Stéphanie Chupin, Lydie Tessier, Odile Blanchet, Hady El Hachem, Juan Manuel Chao de la Barca, Pascal Reynier, Pascale MayPanloup Tags: ORIGINAL ARTICLE Source Type: research

Short anogenital distance is associated with testicular germ cell tumour development
AbstractBackgroundTesticular germ cell tumour is a multifactorial disease in which various genetic and environmental factors play a role. Testicular germ cell tumour is part of the testicular dysgenesis syndrome which includes also cryptorchidism, hypospadias, oligo/azoospermia and short anogenital distance.ObjectivesThe primary objective was to examine anogenital distance in testicular germ cell tumour cases and healthy fertile controls. The secondary objective was to assess the (CAG)n polymorphism of the Androgen Receptor gene in relationship with anogenital distances and testicular germ cell tumour development.Material ...
Source: Andrology - August 5, 2020 Category: Urology & Nephrology Authors: Daniel Moreno ‐Mendoza, Elena Casamonti, Antoni Riera‐Escamilla, Sara Pietroforte, Giovanni Corona, Eduardo Ruiz‐Castañe, Csilla Krausz Tags: ORIGINAL ARTICLE Source Type: research

COVID ‐19 and human spermatozoa—Potential risks for infertility and sexual transmission?
This article reviews the roles played by these various cellular constituents in maintaining the vitali ty of human spermatozoa and their competence for fertilization. The reproductive consequences of a viral attack on these systems, in terms of fertility and the risk of sexual transmission, are currently unknown. However, we should be alive to the possibility that there may be reproductive consequenc es of COVID‐19 infection in young males that go beyond their capacity to survive a viral attack. (Source: Andrology)
Source: Andrology - August 5, 2020 Category: Urology & Nephrology Authors: Robert John Aitken Tags: Opinion Article Source Type: research

The role of resistin on metabolic syndrome ‐induced erectile dysfunction and the possible therapeutic effect of Boldine
ConclusionMetS caused a deterioration in erectile function accompanied by an increase in resistin expression and a reduction in eNOS enzyme activation in the rat penile tissues. Boldine treatment resulted in an improvement in erectile function, independent of resistin expression. (Source: Andrology)
Source: Andrology - August 5, 2020 Category: Urology & Nephrology Authors: Erkan Kara, Erkan Kahraman, Ezgi Dayar, Gunay Yetik Anacak, Omer Demir, Sedef Gidener, Nese Atabey, Nergiz Durmus Tags: ORIGINAL ARTICLE Source Type: research

The protein YWHAE (14 ‐3‐3 epsilon) in spermatozoa is essential for male fertility
In this study, we investigated the roles of 14‐3‐3η and 14‐3‐3ε isoforms in spermatogenesis.Materials and methodsTo study the in vivo function of 14 ‐3‐3η and 14‐3‐3ε in spermatogenesis, we generated testis‐specific and global knockout mice for each of 14‐3‐3η and 14‐3‐3ε isoforms (CKO and GKO, respectively). Computer‐assisted semen analysis was used to assess sperm motility, while immunohistochemical studies were conduct ed to check spermatogenesis.ResultsAlthough both 14 ‐3‐3η and 14‐3‐3ε isoforms were present in mouse testis, only the ex...
Source: Andrology - August 5, 2020 Category: Urology & Nephrology Authors: Alaa Eisa, Souvik Dey, Alex Ignatious, Wesam Nofal, Rex A. Hess, Manabu Kurokawa, Douglas Kline, Srinivasan Vijayaraghavan Tags: ORIGINAL ARTICLE Source Type: research

Sperm morphology: what implications on the assisted reproductive outcomes?
AbstractObjectiveTo evaluate the impact of sperm morphology (SM) on laboratory and pregnancy outcomes in conventional intracytoplasmic sperm injection (c ‐ICSI) cycles, using the egg donation model to minimize female confounding variables.Materials and methodsWe retrospectively collected data of oocyte donation cycles from October 2016 to February 2020. Median seminal parameters, total (1 ‐2‐3PN) fertilization rate (FR), 2PN FR, cleavage rate (CR), implantation rate (IR), pregnancy rate (PR), miscarriage rate (MR) and live birth rate (LBR) were collected. The study population was divided into three groups: Group 1 wi...
Source: Andrology - August 5, 2020 Category: Urology & Nephrology Authors: Gianmartin Cito, Rita Picone, Rossella Fucci, Claudia Giachini, Elisabetta Micelli, Andrea Cocci, Patrizia Falcone, Andrea Minervini, Marco Carini, Alessandro Natali, Maria Elisabetta Coccia Tags: ORIGINAL ARTICLE Source Type: research

Up ‐regulated Expression of NMDA Receptor in the Paraventricular Nucleus Shortens Ejaculation Latency in Rats with Experimental Autoimmune Prostatitis
AbstractBackgroundEstimated 30 ‐40% of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) suffer from premature ejaculation (PE), which is difficult to cure, but the mechanism is still unknown. Based on the results of our previous clinical studies and animal experiments, we propose that the glutamatergic s ystem dysfunction in the paraventricular nucleus (PVN) may be involved.MethodsTo test this hypothesis, we used experimental autoimmune prostatitis (EAP) rats to investigate the effects of CP/CPPS on ejaculation behavior through integrating copulatory behavior testing, neuroelectrophysiologic exper...
Source: Andrology - August 4, 2020 Category: Urology & Nephrology Authors: Jie Yang, Qi ‐jie Zhang, Jia‐yi Zhang, Ya‐min Wang, Guo‐qing Zhu, Ning‐hong Song, Zeng‐jun Wang, Jian‐huai Chen, Jia‐dong Xia Tags: ORIGINAL ARTICLE Source Type: research

Is there a role for 5 α‐reductase inhibitors in transgender individuals?
AbstractAltering sex steroid levels is the mainstay in the medical treatment of transgender and gender ‐diverse individuals who pursue it. By increasing or decreasing the serum concentrations of androgens and estrogens, an individual’s body can either masculinize or feminize. This commentary will explore the important clinical question regarding whether the antiandrogen class of 5α‐reductase i nhibitors should be considered as an effective and safe treatment option for transfeminine and/or transmasculine individuals. (Source: Andrology)
Source: Andrology - August 4, 2020 Category: Urology & Nephrology Authors: Michael S. Irwig Tags: OPINION ARTICLE Source Type: research

Expression and roles of system L amino acid transporters in human embryonal carcinoma cells
ConclusionTaken together, these results shed light on the roles of system L amino acid transporters in TGCTs. Therefore, system L amino acid transporters could provide novel therapeutic targets for treatment against TGCTs. (Source: Andrology)
Source: Andrology - August 2, 2020 Category: Urology & Nephrology Authors: Kasit Chatsirisupachai, Sarunya Kitdumrongthum, Wittaya Panvongsa, Keatdamrong Janpipatkul, Wittawinittawin Worakitchanon, Sarat Lertjintanakit, Patompon Wongtrakoongate, Arthit Chairoungdua Tags: ORIGINAL ARTICLE Source Type: research

Performance and safety of treatment options for erectile dysfunction in patients with spinal cord injury: a review of the literature
ConclusionsThe best treatment options for ED in SCI patients emerged to be PDE5 ‐Is and ICI. The choice of ED treatment should be based on several aspects, including residual erectile function, SCI location and patients’ comorbidities. Future studies assessing the applicability of less well studied treatments, as well as evaluating innovative options, are needed in this spe cific population. (Source: Andrology)
Source: Andrology - August 2, 2020 Category: Urology & Nephrology Authors: Luca Afferi, J ürgen Pannek, Arthur Louis Burnett, Cedric Razaname, Stamatina Tzanoulinou, Wojciech Bobela, Rodrigo Araujo Fraga da Silva, Mikael Sturny, Nikos Stergiopulos, Julian Cornelius, Marco Moschini, Christophe Iselin, Andrea Salonia, Tags: REVIEW ARTICLE Source Type: research

Over ‐expression of hsa_circ_0000116 in patients with non‐obstructive azoospermia and its predictive value in testicular sperm retrieval
ConclusionWe report for the first time that hsa_circ_0000116 may play pivotal roles in regulating spermatogenesis and may also be a potential biomarker for the diagnosis and treatment of NOA, while acting as a predictive tool for the rate of successful testicular sperm retrieval in NOA patients. (Source: Andrology)
Source: Andrology - July 31, 2020 Category: Urology & Nephrology Authors: Mo ‐qi Lv, Liang Zhou, Pan Ge, Yi‐xin Li, Jian Zhang, Dang‐xia Zhou Tags: ORIGINAL ARTICLE Source Type: research