Combination of fetuin and trehalose in presence of low glycerol has beneficial effects on freeze ‐thawed ram sperm
AbstractBackroundFreeze ‐thawing process negatively affects ram sperm in terms of sperm quality, DNA integrity and antioxidant defence system. Thus, antioxidant supplementation of sperm during freeze‐thawing is suggested to improve sperm parameters.ObjectivesThe aim of this study was to determine the effects of fetuin and trehalose added into ram semen extender on sperm parameters, antioxidant paremeters, antioxidant ‐related gene expressions and DNA integrity during the freeze‐thawing process, in low glycerol concentration.MethodsSemen samples collected from six mature rams were pooled and splitted into equal aliq...
Source: Andrology - January 12, 2021 Category: Urology & Nephrology Authors: Mustafa Numan Bucak, P ınar Peker Akalın, Nazan Keskin, Mustafa Bodu, Ali Erdem Öztürk, Pinar Ili, Hüseyin Özkan, Tohid Rezaei Topraggaleh, Halil Ozancan Arslan, Nuri Başpınar, Sükrü Dursun Tags: ORIGINAL ARTICLE Source Type: research

COVID ‐19 and male reproduction: current research and unknown factors
ConclusionCurrent studies suggest that semen is rarely considered a carrier of SARS ‐CoV‐2 genetic material during the infection period but not in the semen of recovered patients. Fatal COVID‐19 may cause testicular structure damage without the presence of virus. (Source: Andrology)
Source: Andrology - January 11, 2021 Category: Urology & Nephrology Authors: Yangcheng Yao, Xiaoqiong Yuan, Linjing Wu, Na Guo, Li Yin, Yufeng Li Tags: REVIEW ARTICLE Source Type: research

Spontaneous pregnancies among infertile couples during assisted reproduction lockdown for COVID ‐19 pandemic
AbstractBackgroundThe worldwide spread of the SARS ‐CoV‐2 infection has profoundly affected all aspects of human life, with tangible consequences in several contexts, including reproduction. However, evidences on the inter‐relation between psychological distress and reproductive medicine are still conflicting.MethodsThe national lockdown imposed in Italy in March ‐May 2020 and the consequent assisted reproductive techniques (ART) activity blockage allowed to evaluate the conception ability of couples who suffered the postponement of ART cycles. In particular, we collected anamnestic, anthropometrical and demographi...
Source: Andrology - January 11, 2021 Category: Urology & Nephrology Authors: Maria Teresa Villani, Daria Morini, Giorgia Spaggiari, Manuela Simoni, Lorenzo Aguzzoli, Daniele Santi Tags: SHORT COMMUNICATION Source Type: research

The impact of five years storage/biobanking at ‐80°C on mouse spermatozoa fertility, physiology and function
ConclusionIt is demonstrated here the possibility to store mouse spermatozoa for up to five years in a –80°C freezer with no significant differences compared to the storage in LN2 in terms of fertilizing ability, sperm viability, intracellular calcium concentration, membrane lipid disorder and mitochondrial activity. (Source: Andrology)
Source: Andrology - January 11, 2021 Category: Urology & Nephrology Authors: Marcello Raspa, Sabrina Putti, Renata Paoletti, Barbara Barboni, Marina Ramal ‐Sanchez, Paola Lanuti, Marco Marchisio, Mario D’Atri, Claudio Ortolani, Stefano Papa, Luca Valbonetti, Nicola Bernabo, Ferdinando Scavizzi Tags: ORIGINAL ARTICLE Source Type: research

The Quality of Systematic Reviews and Meta ‐Analyses Assessing the Treatment and Management of Male Infertility
ConclusionsThe methodological quality of SRs/MAs should be assessed to ensure high ‐quality evidence for clinical practice guidelines in MFI treatment and management. This review highlights a need for increased effort to publish high‐quality studies in MFI treatment and management. (Source: Andrology)
Source: Andrology - January 11, 2021 Category: Urology & Nephrology Authors: Hriday P. Bhambhvani, Daniel R. Greenberg, Michael L. Eisenberg Tags: ORIGINAL ARTICLE Source Type: research

Optimal vacuum erectile device therapy regimen for penile rehabilitation in a bilateral cavernous nerve crush rat model
AbstractBackgroundVacuum erectile device (VED) therapy has been widely used in penile rehabilitation after radical prostatectomy; however, there is no consensus on the best regimen.ObjectivesTo explore an optimal VED therapy regimen in bilateral cavernous nerve crush (BCNC) rat model.Materials/MethodsAdult male rats were used to measure the effects of different durations (1 ‐30 min) of VED treatment on penile length, penile blood gas analysis, and adverse effects. Forty‐eight adult male rats were randomly divided into Sham, BCNC and VED treatment groups (2‐3‐2‐3 min, 4‐3‐3 min, 5‐5 min, and 10 min). Penile ...
Source: Andrology - January 8, 2021 Category: Urology & Nephrology Authors: Ming Ma, Feng Qin, Changjing Wu, Wenfeng Xiong, Botao Yu, Shanzun Wei, Chunxu Huang, Jianrong Xu, Xinzong Yang, Jiuhong Yuan Tags: ORIGINAL ARTICLE Source Type: research

Molecular expression and functional features of Kv7 channels in human prostate smooth muscle
In this study, we examined the molecular characteristics and physiological roles of Kv7 channels in HPrSM.Materials and methodsThe expressions of KCNQ1 –5 (Kv7 channel pore‐forming α‐subunits) and KCNE1‐5 (β‐regulatory subunits) isoforms in HPrSM were examined using real‐time PCR. The relaxation effect of ML213 was investigated by cumulatively adding ML213 to the prostate strips. Kv7 currents were recorded using an amphotericin‐B pe rforated patch‐clamp technique.ResultsIn HPrSM cells, KCNQ4, KCNQ5, and KCNE4 isoforms were predominantly expressed, while KCNQ1, KCNQ5, and KCNE3 isoforms were t...
Source: Andrology - January 8, 2021 Category: Urology & Nephrology Authors: Joongwon Choi, Deok Hyun Han, Mee Ree Chae, Hyun Hwan Sung, Su Jeong Kang, Jimin Shin, Sung Won Lee Tags: ORIGINAL ARTICLE Source Type: research

Association between latent toxoplasmosis and fertility parameters of men
ConclusionOur results suggest that latent toxoplasmosis affects certain semen parameters (sperm count and motility), but does not seem to affect sperm morphology and semen volume. Impairment of semen parameters may be either a side effect of the presence ofToxoplasma gondii in male reproductive organs or a product of manipulation activity of the parasite aimed to increase the efficiency of the sexual route of its transmission. Tobacco smoking also appears to exacerbate the negative impact of toxoplasmosis on semen parameters. (Source: Andrology)
Source: Andrology - January 8, 2021 Category: Urology & Nephrology Authors: Jana Hlav áčová, Jaroslav Flegr, Karel Řežábek, Pavel Calda, Šárka Kaňková Tags: ORIGINAL ARTICLE Source Type: research

Neutral effect of Exenatide on Serum Testosterone in Men with Type 2 Diabetes Mellitus: a Prospective Cohort
AbstractBackgroundEndogenous testosterone increases with weight loss from diet, exercise, and bariatric surgery. However, little is known about testosterone levels after weight loss from medication.ObjectivesUncover the effects of Glucagon ‐Like Peptide‐1 receptor agonist (GLP‐1 RA) therapy on serum testosterone.Materials and MethodsProspective cohort study of men starting GLP ‐1 RA therapy for type 2 diabetes mellitus.Results51 men lost 2.27 kg (p = 0.00162) and their HbA1c values improved by 0.7% (p = 0.000503) after 6 months of GLP ‐1 RA therapy. There was no significant change in testosterone for the group as...
Source: Andrology - January 5, 2021 Category: Urology & Nephrology Authors: Sky Graybill, Jennifer Hatfield, Maria Kravchenko, Darrick Beckman, Joshua Tate, Alexis Beauvais, Philip Clerc, Desarae Davila, Whitney Forbes, Jana Wardian, Matthew Kemm, Abegail Hubberd, Mark True Tags: ORIGINAL ARTICLE Source Type: research

Periodontitis, erectile dysfunction, reproductive hormones, and semen quality: A systematic review
ConclusionThe results of this systematic review revealed a significant association between periodontitis and ED, although the responsible mechanisms remain unclear. The potential associations between sex hormone levels, semen quality, and periodontitis are yet to be demonstrated. In order to improve patient management, dentists and physicians need to be aware of the association between male sexual health problems and periodontitis. (Source: Andrology)
Source: Andrology - January 2, 2021 Category: Urology & Nephrology Authors: Bastien Lecaplain, Zahi Badran, Assem Soueidan, Tony Prud'homme, Alexis Gaudin Tags: REVIEW ARTICLE Source Type: research

Hepatitis B virus surface protein induces sperm dysfunction through the activation of a Bcl2/Bax signaling cascade triggering mediated apoptosis
ConclusionHBs exposure can activate the Bax/Bcl2 signaling cascade that triggers AIF/Endo G ‐mediated apoptosis, resulting in sperm DNA fragmentation, sperm injury and death, and a decrease in the sperm fertilizing capacity. This new knowledge will help to evaluate the negative impact of HBV on male fertility in HBV‐infected patients. (Source: Andrology)
Source: Andrology - December 31, 2020 Category: Urology & Nephrology Authors: Ting ‐Ting Han, Ji‐Hua Huang, Jiang Gu, Qing‐Dong Xie, Ying Zhong, Tian‐Hua Huang Tags: ORIGINAL ARTICLE Source Type: research

Sex steroid hormones, leptin, and high ‐sensitivity C‐reactive protein levels in adolescents
AbstractBackgroundThe association of sex hormones with C ‐reactive protein (CRP) levels has been reported. However, this association remains unexplored in children in whom important anthropometric and hormonal changes are taking place.ObjectivesTo analyze the association between high ‐sensitivity CRP (hs‐CRP) and testosterone, estradiol and sex hormone‐binding globulin (SHBG) levels in a population‐based sample of adolescents, and to evaluate the influence of leptin levels on this association.Materials and MethodsThe sample population of this cross ‐sectional study was comprised of 338 male and 385 female adole...
Source: Andrology - December 30, 2020 Category: Urology & Nephrology Authors: Olaya Dios, Leticia Herrero, Claudia Vales ‐Villamarín, Ignacio Mahíllo‐Fernández, Leandro Soriano‐Guillén, Carmen Garcés Tags: ORIGINAL ARTICLE Source Type: research

Fertility Potential in Adult Men Treated for Uncorrected Bilateral Cryptorchidism: A Systematic Literature Review and Analysis of Case Reports
ConclusionFertility is possible in adult men with inguinal bUDT following orchidopexy. Subsequent sperm retrieval may involve ejaculated specimens or delayed TESE. TESE performed prior to or at time of orchidopexy is unlikely to be of benefit. (Source: Andrology)
Source: Andrology - December 22, 2020 Category: Urology & Nephrology Authors: Wade Muncey, Rahul Dutta, Ryan P. Terlecki, Lynn L. Woo, Kyle Scarberry Tags: ORIGINAL ARTICLE Source Type: research

Is there a temporal trend in semen quality in Belgian candidate sperm donors and in sperm donors ’ fertility potential from 1995 onwards?
AbstractBackgroundA recent meta ‐regression analysis reported a temporal trend in sperm count showing a significant decline in sperm count between 1973 and 2011. This decline is thought to affect fecundity. Moreover, semen quality is considered of key interest to public health given its association with all‐cause male morbidit y/mortality. The issue requires ongoing investigation due to geographical variation in semen quality and methodological errors in semen analysis.ObjectiveTo study whether there is a temporal trend in semen quality in Belgian candidate sperm donors and in sperm donors ’ fertility potential.M...
Source: Andrology - December 18, 2020 Category: Urology & Nephrology Authors: Alessa Sugihara, Diane De Neubourg, Usha Punjabi Tags: ORIGINAL ARTICLE Source Type: research

Sex steroid hormones, leptin and high sensitivity C ‐Reactive Protein levels in adolescents
AbstractBackgroundThe association of sex hormones with C ‐reactive protein (CRP) levels has been reported. However, this association remains unexplored in children in whom important anthropometric and hormonal changes are taking place.ObjectivesTo analyze the association between high sensitivity CRP (hs ‐CRP) and testosterone, estradiol and sex hormone binding globulin (SHBG) levels in a population‐based sample of adolescents, and to evaluate the influence of leptin levels on this association.Materials and MethodsThe sample population of this cross ‐sectional study was comprised of 338 male and 385 female adolescen...
Source: Andrology - December 16, 2020 Category: Urology & Nephrology Authors: Olaya Dios, Leticia Herrero, Claudia Vales ‐Villamarín, Ignacio Mahíllo‐Fernández, Leandro Soriano‐Guillén, Carmen Garcés Tags: ORIGINAL ARTICLE Source Type: research

Periodontitis, erectile dysfunction, reproductive hormones and semen quality: A systematic review
ConclusionThe results of this systematic review revealed a significant association between periodontitis and ED, although the responsible mechanisms remain unclear. The potential associations between sex hormone levels, semen quality and periodontitis are yet to be demonstrated. In order to improve patient management, dentists and physicians need to be aware of the association between male sexual health problems and periodontitis. (Source: Andrology)
Source: Andrology - December 15, 2020 Category: Urology & Nephrology Authors: Bastien Lecaplain, Zahi Badran, Assem Soueidan, Tony Prud ’homme, Alexis Gaudin Tags: REVIEW ARTICLE Source Type: research

TNF ‐α inhibits GDNF levels in Sertoli cells, through a NF‐κB‐dependent, HES1‐dependent mechanism.
ConclusionsBecause of the importance of GDNF for spermatogonial stem cell self ‐renewal and proliferation, this data may give important insights on how cytokine signals in the testis modulate the expression of niche‐derived factors. (Source: Andrology)
Source: Andrology - December 12, 2020 Category: Urology & Nephrology Authors: Sara Di Persio, Donatella Starace, Chiara Capponi, Rossana Saracino, Stefania Fera, Antonio Filippini, Elena Vicini Tags: ORIGINAL ARTICLE Source Type: research

Postnatal metformin treatment alters rat Sertoli cell proliferation and daily sperm production
Discussion and conclusionThese results suggest that metformin treatment may lead to a decrease in Sertoli cell proliferation, a concomitant altered expression of cell cycle regulators and ultimately, a reduction in daily sperm production in adult animals. (Source: Andrology)
Source: Andrology - December 11, 2020 Category: Urology & Nephrology Authors: Gustavo Marcelo Rindone, Agostina Gorga, Eliana Herminia Pellizzari, Mar ía del Carmen Camberos, María Noel Galardo, Vanina Gabriela Da Ros, Mariano Gabriel Buffone, Silvina Beatriz Meroni, María Fernanda Riera Tags: ORIGINAL ARTICLE Source Type: research

In vitro survival kinetics of microfluidic ‐sorted bovine spermatozoa
This study primarily aims to obtain baseline information on sorted spermatozoa according to its characteristics andin vitro life span.Materials and MethodsFrozen ‐thawed bull semen was subjected to microfluidic sperm sorting using diffuser‐type microfluidic sperm sorter (DMSS). After sorting, samples were collected as the sorted spermatozoa and unsorted residual spermatozoa and incubated at 37°C for subsequent evaluation. The samples were assessed at di fferent time points (0 or 1, 6, and 24 h) in terms of motility, which was measured by computer‐assisted sperm analysis (CASA), membrane integrity, mitochondrial f...
Source: Andrology - December 11, 2020 Category: Urology & Nephrology Authors: Kazuko Ogata, Maria Portia B. Nagata, Hirofumi Nishizono, Tadayuki Yamanouchi, Hideo Matsuda, Yuki Ogata, Kumiko Takeda, Yutaka Hashiyada, Kenichi Yamashita Tags: ORIGINAL ARTICLE Source Type: research

Construction and internal validation of a prediction nomogram for acquired premature ejaculation (APE) in PE patients
ConclusionWe identified 4 independent predictors for APE and demonstrated the potential significant differences in psychoticism between LPE and APE patients. This was the first internally validated predictive APE nomogram where good discrimination and calibration were applied, and it offers a promising role in clinical practice. More studies are necessary for verification of its universal applicability. (Source: Andrology)
Source: Andrology - December 8, 2020 Category: Urology & Nephrology Authors: Lei Zhang, Xinlong Dun, Guangdong Hou, Yu Zheng, Dongen Ju, Ping Meng, Fei Liu, Jiarui Yuan, Long Jin, Tao Jiang, Ming Gao, Jianlin Yuan Tags: ORIGINAL ARTICLE Source Type: research

Testicular Steroid Sulfatase overexpression is associated with Leydig cell dysfunction in primary spermatogenic failure
AbstractBackgroundDecreased testosterone (T) to LH ratio and increased 17 β‐estradiol (E2) serum concentrations represent a common finding among patients with severe spermatogenic failure, suggesting a concurrent Leydig cell steroidogenic dysfunction. Aromatase over‐expression has been associated with increased serum and intratesticular E2 in these patients. However, it is unknown whether the sulfatase pathway contributes to the increased availability of active estrogens in patients with primary spermatogenic failure.ObjectivesTo assess estrogen sulfotransferase (SULT1E1) and steroid sulfatase (STS) mRNA abundance...
Source: Andrology - December 8, 2020 Category: Urology & Nephrology Authors: Maria C. Lardone, Ian N. Reyes, Eliana Ortiz, Antonio Piottante, Cristi án Palma, Mauricio Ebensperger, Andrea Castro Tags: ORIGINAL ARTICLE Source Type: research

Male factor infertility trends throughout the last 10  years: Report from a tertiary‐referral academic andrology centre
AbstractBackgroundTrends of male factor causes of couples' infertility over time have been poorly investigated.ObjectiveWe investigated trends in the causes of pure male factor infertility (MFI) throughout the last 10  years in a tertiary‐referral academic andrology center.Material and MethodsBaseline characteristics at first presentation from a cohort of 1647 consecutive male factor infertility patients belonging to primary infertile couples between 2008 and 2018 have been comprehensively collected over time. Seven major causes of male factor infertility were identified: varicocoele; history of cryptorchidism; hypo...
Source: Andrology - December 6, 2020 Category: Urology & Nephrology Authors: Giuseppe Fallara, Walter Cazzaniga, Luca Boeri, Paolo Capogrosso, Luigi Candela, Edoardo Pozzi, Federico Belladelli, Nicol ò Schifano, Eugenio Ventimiglia, Costantino Abbate, Enrico Papaleo, Paola Viganò, Francesco Montorsi, Andrea Salonia Tags: ORIGINAL ARTICLE Source Type: research

Varicocoele and oxidative stress: New perspectives from animal and human studies
ConclusionSince oxidative stress is an important feature of the reproductive pathology of VCL, therapeutic strategies such as the administration of appropriate antioxidants could be undertaken as a complementary non ‐invasive treatment line. (Source: Andrology)
Source: Andrology - December 6, 2020 Category: Urology & Nephrology Authors: Mazdak Razi, Marziyeh Tavalaee, Farshid Sarrafzadeh ‐Rezaei, Aron Moazamian, Parviz Gharagozloo, Joël R. Drevet, Mohammad‐Hossein Nasr‐Eshafani Tags: REVIEW ARTICLE Source Type: research

Supplementation of cryoprotectant with Pinus massoniana bark extract improves human sperm vitality and fertility potential
ConclusionSupplementing cryoprotectant with PMBE improves human sperm quality after cryo ‐resuscitation by reducing oxidative stress and stabilizing the functional proteins ISYNA1 and AKT1. PMBE addition improves the fertilization outcome of oxidative stress‐damaged sperm. (Source: Andrology)
Source: Andrology - December 5, 2020 Category: Urology & Nephrology Authors: Yingya Li, Tingyu Zhang, Yanping Jia, Hao Yang, Wenqiang Liu, Jiaping Pan, Yu Wang, Shanshan Liang, Kunming Li Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
Andrology, Volume 8, Issue S2, Page 1-2, December 2020. (Source: Andrology)
Source: Andrology - December 4, 2020 Category: Urology & Nephrology Tags: Issue Information Source Type: research

Index of Abstract Authors
Andrology, Volume 8, Issue S2, Page 85-94, December 2020. (Source: Andrology)
Source: Andrology - December 4, 2020 Category: Urology & Nephrology Tags: Index of Abstract Authors Source Type: research

Oral Presentations Abstracts Full Text
Andrology, Volume 8, Issue S2, Page 68-84, December 2020. (Source: Andrology)
Source: Andrology - December 4, 2020 Category: Urology & Nephrology Tags: Abstracts Source Type: research

Speaker Abstracts
Andrology, Volume 8, Issue S2, Page 23-43, December 2020. (Source: Andrology)
Source: Andrology - December 4, 2020 Category: Urology & Nephrology Tags: Abstracts Source Type: research

User Guide
Andrology, Volume 8, Issue S2, Page 21-22, December 2020. (Source: Andrology)
Source: Andrology - December 4, 2020 Category: Urology & Nephrology Tags: Abstracts Source Type: research

Poster Session
Andrology, Volume 8, Issue S2, Page 44-67, December 2020. (Source: Andrology)
Source: Andrology - December 4, 2020 Category: Urology & Nephrology Tags: Abstracts Source Type: research

Schedule at a Glance
Andrology, Volume 8, Issue S2, Page 3-14, December 2020. (Source: Andrology)
Source: Andrology - December 4, 2020 Category: Urology & Nephrology Tags: Schedule at a Glance Source Type: research

Sponsors and Exhibitors
Andrology, Volume 8, Issue S2, Page 19-20, December 2020. (Source: Andrology)
Source: Andrology - December 4, 2020 Category: Urology & Nephrology Tags: Sponsors and Exhibitors Source Type: research

General Information
Andrology, Volume 8, Issue S2, Page 18-18, December 2020. (Source: Andrology)
Source: Andrology - December 4, 2020 Category: Urology & Nephrology Tags: General Information Source Type: research

Welcome Notes
Andrology, Volume 8, Issue S2, Page 15-17, December 2020. (Source: Andrology)
Source: Andrology - December 4, 2020 Category: Urology & Nephrology Tags: Welcome Notes Source Type: research

SECRET ® ‐ SExual Chronicle REcording Table: validation and reliability
ConclusionsSECRET® represents a novel, simple instrument to record a patient ’s sexual history in daily clinical practice and clinical research. (Source: Andrology)
Source: Andrology - December 4, 2020 Category: Urology & Nephrology Authors: Claudia Zaccaro, Francesco Lotti, Simone Morselli, Arcangelo Sebastianelli, Francesca Frizza, Barbara Bigazzi, Andrea Liaci, Tommaso Cai, Linda Vignozzi, Graziano Vignolini, Sergio Serni, Stavros Gravas, Ignacio Moncada, Andrea Salonia, Maur Tags: ORIGINAL ARTICLE Source Type: research

Sperm immunization and rat spermatogenesis: Dysfunctional blood ‐testis barrier and perturbed Sertoli cell cytoskeleton
ConclusionThe observed pathological characteristics demonstrate how inflammatory cells influence Sertoli cells, leading to impaired spermatogenesis, and suggest that this sperm immunization method provides a new rat model of autoimmune orchitis. (Source: Andrology)
Source: Andrology - December 4, 2020 Category: Urology & Nephrology Authors: Junko Noguchi, Hiroyuki Kaneko, Mitsumi Ikeda, Kazuhiro Kikuchi, Thahn Quang Dang ‐Nguyen, Tadashi Furusawa Tags: ORIGINAL ARTICLE Source Type: research

The association between cannabis use and testicular function in men: a systematic review and meta ‐analysis
ConclusionsThe current evidence does not suggest clinically significant associations between cannabis use and testicular function. However, we cannot exclude an effect of cannabis due to the limited and heterogeneous studies. Additional, well ‐designed studies will be needed to define the association between cannabis use and the male reproductive system. (Source: Andrology)
Source: Andrology - November 29, 2020 Category: Urology & Nephrology Authors: Federico Belladelli, Francesco Del Giudice, Alex Kasman, Tina Kold Jensen, Niels J ørgensen, Andrea Salonia, Michael L Eisenberg Tags: REVIEW ARTICLE Source Type: research

Does sperm origin —ejaculated or testicular—affect embryo morphokinetic parameters?
This study included a retrospective analysis of morphokinetic parameters performed by TLM between 2013 and2017. The developmental processes and morphokinetic parameters of 419 embryos obtained from couples with MFI attributed to oligoasthenoteratozoospermia (OAT),158 embryos derived from surgically extracted testicular sperm (TS) from couples diagnosed with non ‐obstructive azoospermia and 190 embryos from couples with normal ejaculated sperm (NES) and female mechanical factor related infertility, were evaluated. A comparison of morphokinetic parameters, implantation and clinical pregnancy rates was performed between the...
Source: Andrology - November 29, 2020 Category: Urology & Nephrology Authors: Gilad Karavani, Yoav Kan ‐Tor, Natali Schachter‐Safrai, Eliahu Levitas, Yuval Or, Assaf Ben‐Meir, Amnon Buxboim, Iris Har‐Vardi Tags: ORIGINAL ARTICLE Source Type: research

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: scrotal ultrasound reference ranges and associations with clinical, seminal and biochemical characteristics
ConclusionsThe present findings will help in better understanding male infertility pathophysiology, impoving its management. (Source: Andrology)
Source: Andrology - November 27, 2020 Category: Urology & Nephrology Authors: Francesco Lotti, Francesca Frizza, Giancarlo Balercia, Arcangelo Barbonetti, Hermann M. Behre, Aldo E. Calogero, Jann ‐Frederik Cremers, Felice Francavilla, Andrea M. Isidori, Sabine Kliesch, Sandro La Vignera, Andrea Lenzi, Marios Marcou, Tags: ORIGINAL ARTICLE Source Type: research

FSHB and FSHR gene variants exert mild modulatory effect on reproductive hormone levels and testis size but not on semen quality: A study of 2,020 men from the general Danish population
ConclusionThe studied polymorphisms have only minor modulating influence on testis size and function in healthy men. We detected subtle effects of the three SNPs on FSH levels, but also effects ofFSHB‐211G>T on calculated free ‐Testosterone/LH ratio, compatible with altered Leydig cell function. Thus, the role of these FSH‐related polymorphisms is complex and modest in men with normal testicular function, but the possible importance of FSH polymorphisms in men with impaired testicular function should be evaluated in f uture studies in more detail. (Source: Andrology)
Source: Andrology - November 25, 2020 Category: Urology & Nephrology Authors: Anne Kirstine Bang, Kristian Almstrup, Loa Nordkap, L ærke Priskorn, Jørgen Holm Petersen, Martin Blomberg Jensen, Marianna Krause, Stine Agergaard Holmboe, Dorte Louise Egeberg Palme, Sofia Boeg Winge, Ulla Nordström Joensen, Inge Ahlmann O Tags: ORIGINAL ARTICLE Source Type: research

Male ‐Factor infertility trends throughout the last 10 years: report from a tertiary‐referral academic andrology centre
AbstractBackgroundTrends of male factor causes of couples ’ infertility over time have been poorly investigated.ObjectiveWe investigated trends in the causes of pure male factor infertility (MFI) throughout the last ten years in a tertiary ‐referral academic andrology centre.Material And MethodsBaseline characteristics at first presentation from a cohort of 1647 consecutive MFI patients belonging to primary infertile couples between 2008 and 2018 have been comprehensively collected over time. Seven major causes of MFI were identified: varicocele; history of cryptorchidism; hypogonadism (primary and secondary); obst...
Source: Andrology - November 24, 2020 Category: Urology & Nephrology Authors: Giuseppe Fallara, Walter Cazzaniga, Luca Boeri, Paolo Capogrosso, Luigi Candela, Edoardo Pozzi, Federico Belladelli, Nicol ò Schifano, Eugenio Ventimiglia, Costantino Abbate, Enrico Papaleo, Paola Viganò, Francesco Montorsi, Andrea Salonia Tags: ORIGINAL ARTICLE Source Type: research

No detection of SARS ‐CoV‐2 from urine, expressed prostatic secretions, and semen in 74 recovered COVID‐19 male patients: A perspective and urogenital evaluation
Discussion and conclusionsTo the best of our knowledge, it is the largest cohort study with longest follow ‐up for urogenital evaluation comprehensively so far. Direct urogenital involvement was not found in the recovered COVID‐19 male patients. SARS‐CoV‐2 RNA was undetectable in the urogenital secretions, and semen quality declined slightly, while hormonal profiles remained normal. Moreover, pat ients with a long time (≥90 days) since recovery had lower total sperm count. Great attention and further study should be conducted and follow‐up on the reproductive function in the following months. (Source: Andrology)
Source: Andrology - November 23, 2020 Category: Urology & Nephrology Authors: Yajun Ruan, Bintao Hu, Zhuo Liu, Kang Liu, Hongyang Jiang, Hao Li, Rui Li, Yang Luan, Xiaming Liu, Gan Yu, Shengfei Xu, Xiaoyi Yuan, Shaogang Wang, Weimin Yang, Zhangqun Ye, Jihong Liu, Tao Wang Tags: ORIGINAL ARTICLE Source Type: research

Seminal human papillomavirus infection and reproduction: a systematic review and meta ‐analysis
ConclusionsHPV in semen may have an impact in sperm quality and reproductive outcomes. Additional well ‐designed studies are warranted to improve the quality of evidence. (Source: Andrology)
Source: Andrology - November 21, 2020 Category: Urology & Nephrology Authors: Jose Moreno ‐ Sepulveda, Osvaldo Rajmil Tags: REVIEW ARTICLE Source Type: research

The impact of the origin of surgical sperm retrieval on placental and embryonic development: The Rotterdam Periconception cohort
ConclusionHere we demonstrate that the first trimester growth trajectory of the placenta is increased in pregnancies conceived after TESE ‐ICSI compared to those conceived after ICSI with ejaculated sperm. Findings are discussed in the light of known differences in sperm DNA integrity, epigenetics, and placental gene expression. (Source: Andrology)
Source: Andrology - November 18, 2020 Category: Urology & Nephrology Authors: Jeffrey Hoek, Willem P.A. Boellaard, Eva S. van Marion, Sten P. Willemsen, Esther.B. Baart, R égine P.M. Steegers‐Theunissen, Sam Schoenmakers Tags: ORIGINAL ARTICLE Source Type: research

Activation of the cannabinoid receptor type 2 by the agonist JWH133 promotes the first wave of in vitro spermatogenesis
ConclusionAfter 30  days of culture, (i) an enrichment of haploid germ cells detected by flow cytometry, (ii) a reduced necrotic area, and (iii) an increase in the density of post‐meiotic germ cells were observed. We showed that the activation of CB2 improves in vitro entry into meiosis and differentiation of spermatogonia, mimicking physiological meiotic transition. (Source: Andrology)
Source: Andrology - November 16, 2020 Category: Urology & Nephrology Authors: Ludovic Dumont, Marion Delessard, Justine Saulnier, Aur élie Rives, Christine Rondanino, Nathalie Rives Tags: Original Article Source Type: research

Dynamics of epigenetic modifications in ICSI embryos from in vitro ‐produced spermatozoa
Discussion and conclusionOur study shows for the first time that the use of in vitro ‐produced spermatozoa alters DNA methylation/demethylation dynamics but has little impact on H3K4me3, H3K27me3 and H3K9ac levels in mouse early embryos. Further work will have to be performed to determine whether the use of these gametes is not deleterious for embryo development before considering a human application. (Source: Andrology)
Source: Andrology - November 14, 2020 Category: Urology & Nephrology Authors: Antoine Oblette, Aur élie Rives‐Feraille, Ludovic Dumont, Marion Delessard, Justine Saulnier, Nathalie Rives, Christine Rondanino Tags: ORIGINAL ARTICLE Source Type: research

Medical, non ‐invasive, and minimally invasive treatment for Peyronie’s disease: A systematic review
ConclusionOptimistically, in the near future, we may witness emergence of efficacious new agents and modalities to revolutionize medical, non ‐invasive, and minimally invasive treatment of this devastating condition. (Source: Andrology)
Source: Andrology - November 14, 2020 Category: Urology & Nephrology Authors: Ahmed I. El ‐Sakka Tags: REVIEW ARTICLE Source Type: research

Seminal plasma components from fertile stallions involved in the epididymal sperm freezability
ConclusionThe composition of the SP probably contributes to semen cryotolerance capacity. Total protein, TAC, PUFA, and some proteins such as Cysteine ‐rich secreted protein 3 could be used as biomarkers for the selection for sperm cryotolerance. (Source: Andrology)
Source: Andrology - November 13, 2020 Category: Urology & Nephrology Authors: Luis Alberto Vieira, Carmen Mat ás, Alejandro Torrecillas, Fara Saez, Joaquín Gadea Tags: ORIGINAL ARTICLE Source Type: research

Abstracts from the American Society of Andrology Spring Conference
Andrology, Volume 8, Issue S1, Page 1-53, November 2020. (Source: Andrology)
Source: Andrology - November 9, 2020 Category: Urology & Nephrology Tags: Abstracts from the American Society of Andrology Spring Conference Source Type: research

Prevalence of CBAVD in azoospermic men carrying pathogenic CFTR mutations ‐ Evaluated in a cohort of 639 non‐vasectomized azoospermic men
AbstractBackgroundMen with obstructive azoospermia (OA) due to impaired development of the genital tract often carry at least one Cystic Fibrosis Transmembrane Conductance RegulatorCFTR mutation.ObjectiveTo determine the frequency of Congenital Bilateral Absence ofVas deferens (CBAVD) in men with azoospermia carryingCFTR gene mutations.Materials and methodsNon ‐vasectomized men with azoospermia referred to our andrological center were consecutively included. All men underwent palpation of the scrotal parts of theVasa deferentia, ultrasonography of the testicles and hormone profile, and genetic analyses. Testicular biopsy...
Source: Andrology - November 7, 2020 Category: Urology & Nephrology Authors: Jens Fedder, Mette W. J ørgensen, Birte Engvad Tags: ORIGINAL ARTICLE Source Type: research