Profiling of epididymal small non ‐protein‐coding RNAs
ConclusionCompelling literature has identified sRNAs as a crucial regulatory tier that allows the epididymis to fulfill its combined roles of sperm transport, maturation, and storage. Continued research in this emerging field will contribute to our growing understanding of the etiology of male factor infertility and potentially allow for the future design of rational therapeutic options for these individuals. (Source: Andrology)
Source: Andrology - April 25, 2019 Category: Urology & Nephrology Authors: B. Nixon, G. N. De Iuliis, M. D. Dun, W. Zhou, N. A. Trigg, A. L. Eamens Tags: Review Article Source Type: research

Nandrolone decanoate and resistance exercise affect prostate morphology and hormone receptor interface in adult rats with implications for the aging process
ConclusionND, either with or without RE, during post ‐puberty stage is able to interfere with the morphophysiology of the prostate. (Source: Andrology)
Source: Andrology - April 22, 2019 Category: Urology & Nephrology Authors: F. de C. Gomes, L. G. de A. Chuffa, W. J. F ávaro, W. R. Scarano, J. S. Melo‐Neto, P. F. F. Pinheiro, R. F. Domeniconi Tags: Original Article Source Type: research

Proteomic characterization of human sperm plasma membrane ‐associated proteins and their role in capacitation
ConclusionsOur results indicate that SMAP inhibit the progress of human sperm capacitation, but only motility changes related to capacitation may be reversed by these proteins. The study of the identified proteins on sperm function and their mechanisms of action on this cell may contribute to the understanding of their role during capacitation. (Source: Andrology)
Source: Andrology - April 19, 2019 Category: Urology & Nephrology Authors: Gabriela Hern ández‐Silva, Jorge Elías Fabián López‐Araiza, Aideé Saray López‐Torres, Fernando Larrea, Víctor Torres‐Flores, Mayel Chirinos Tags: Original Article Source Type: research

Semen quality is affected by HLA class I alleles together with sexually transmitted diseases
ConclusionsThe application of HLA*PRG:LA tool to the study of male infertility provided novel insights for anHLA correlation with semen quality, namely among SHV and OLI phenotypes. The discovery of anHLA ‐A*29:02/HPV crosstalk, together with former reports ofHLA alleles conferring resistance –susceptibility to diverse human pathogens, raises the hypothesis of a mechanistic link between male infertility,HLA polymorphism, and host response to STD. (Source: Andrology)
Source: Andrology - April 19, 2019 Category: Urology & Nephrology Authors: P. I. Marques, J. C. Gon çalves, C. Monteiro, B. Cavadas, L. Nagirnaja, N. Barros, A. Barros, F. Carvalho, A. M. Lopes, S. Seixas Tags: Original Article Source Type: research

Hepcidin is not essential for mediating testosterone's effects on erythropoiesis
ConclusionAlthough hepcidin suppression by testosterone increases iron availability and erythropoiesis, hepcidin suppression is not essential for mediating testosterone's effects on erythropoiesis in healthy mice. (Source: Andrology)
Source: Andrology - April 19, 2019 Category: Urology & Nephrology Authors: W. Guo, P. J. Schmidt, M. D. Fleming, S. Bhasin Tags: Original Article Source Type: research

Influence of male human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection on the reproductive outcomes in serodiscordant couples: a case –control study
AbstractBackgroundNowadays, serodiscordant couples (SDCs) with human immunodeficiency virus (HIV) or hepatitis C virus (HCV) ‐infected men have the chance to conceive safely, giving birth with a minimum risk of cross‐infection.ObjectiveTo assess the impact of male HIV and HCV infection on the assisted reproductive technologies (ART) outcomes in SDCs, with HIV or HCV seropositive men and negative partners.Materials and methodsOf 153 couples: 24 in Group 1 (HIV ‐seropositive men), 60 in Group 2 (HCV‐seropositive men) and 69 in Group 3 (controls). Sperm‐washing procedure was performed using a three‐step system. Fr...
Source: Andrology - April 16, 2019 Category: Urology & Nephrology Authors: G. Cito, M. E. Coccia, R. Fucci, R. Picone, A. Cocci, G. I. Russo, F. Rizzello, M. Trotta, L. Badolato, V. Basile, L. Criscuoli, S. Serni, M. Carini, A. Natali Tags: Original Article Source Type: research

Issue Information
Andrology, Volume 7, Issue 3, Page i-iii, May 2019. (Source: Andrology)
Source: Andrology - April 13, 2019 Category: Urology & Nephrology Tags: Issue Information Source Type: research

Relationship between varicocele and platelet indices: changes of mean platelet volume before and after operation
AbstractBackgroundThe correlation between the increased mean platelet volume and varicocele is controversial.ObjectivesWe designed this research to demonstrate the correlation relationship between varicocele and mean platelet volume by studying the changes of mean platelet volume in patients with varicocele before and after operation.Materials and methodsA total of 317 patients with left unilateral varicocele underwent operation, and 293 healthy adult males were enrolled in the study. We collected diagnostic data for preoperative patients through physical examination, color Doppler ultrasonography, and blood routine, and r...
Source: Andrology - April 10, 2019 Category: Urology & Nephrology Authors: Q. ‐F. Zhang, J.‐H. Liang, T.‐H. He, Z.‐X. Huang, Q.‐L. Liu, X. Zhang, S.‐L. Shen, G.‐Y. Li, W.‐R. Song Tags: Original Article Source Type: research

Combined nestorone –testosterone gel suppresses serum gonadotropins to concentrations associated with effective hormonal contraception in men
AbstractBackgroundNovel male ‐based contraceptives are needed to broaden family planning choices. A progestin, Nestorone® (Nes) gel, plus a testosterone (T) gel suppresses sperm concentrations to levels associated with effective contraception in normal men. However, administration of two gels on different parts of the body daily is impractical.ObjectiveCompare the effectiveness of daily application of a single, combined 8.3  mg Nes‐62.5 mg T gel (Nes‐T) vs. 62.7 mg T gel to suppress serum FSH and LH concentrations to ≤1.0 IU/L (a threshold associated with suppression of sperm concentrations...
Source: Andrology - April 10, 2019 Category: Urology & Nephrology Authors: B. D. Anawalt, M. Y. Roth, J. Ceponis, V. Surampudi, J. K. Amory, R. S. Swerdloff, P. Y. Liu, C. Dart, W. J. Bremner, R. Sitruk ‐Ware, N. Kumar, D. L. Blithe, S. T. Page, C. Wang Tags: Original Article Source Type: research

Prognostic factors in metastatic germ ‐cell cancer
AbstractDetermining stage and anticipating prognosis are the two crucial steps after the diagnosis of a germ ‐cell cancer that both guide subsequent treatment decisions. This review focuses on metastatic disease, which means germ‐cell cancers beyond stage I limited to the testis. In the past, major centers developed separate staging and prognostic classifications for metastatic germ‐cell cancer, whic h heavily impaired communication and comparisons across clinical trials. More recently, the classification system of the International Germ‐Cell Cancer Collaborative Group (IGCCCG) has found acceptance worldwide and is...
Source: Andrology - April 10, 2019 Category: Urology & Nephrology Authors: J örg Beyer Tags: Review Article Source Type: research

Family history of prostate cancer and age ‐related trend of testosterone levels among US males: NHANES 2003–2004
ConclusionThis preliminary analysis suggested that men with a family history of PCa may experience a sharper decline in T level over the life course as compared to males without a family history. However, no conclusions can be made due to small sample sizes. Further longitudinal studies with large sample sizes are needed. (Source: Andrology)
Source: Andrology - April 5, 2019 Category: Urology & Nephrology Authors: X. Zhang, Y. Zhong, N. Taylor, X. Xu Tags: Original Article Source Type: research

The association between sperm head elongation and semen quality
The objective of this retrospective study was to explore the association between sperm head elongation (Width/Length ratio) and routine semen parameters.Materials and methodsFrom January 2012 to December 2017, 63  866 semen samples were collected from male subjects at 18–60 years of age. Sperm head elongation and routine semen parameters (semen volume, sperm concentration, motility, etc.) were examined with computer‐assisted semen analysis (CASA) systems in order to evaluate the association between elo ngation and semen quality.ResultsLogistic and linear regression models showed that the value of elongati...
Source: Andrology - April 1, 2019 Category: Urology & Nephrology Authors: F. Chen, L. Gao, H. Zhou, L. Guo, Q. Chen, Y. Gan, X. Sun, Q. Li, K. Wang Tags: Original Article Source Type: research

Nine genes abundantly expressed in the epididymis are not essential for male fecundity in mice
Discussion and conclusionWe revealed that nine genes abundantly expressed in the caput and corpus epididymis are dispensable for sperm function and male fecundity. CRISPR/Cas9 ‐mediated KO mice generation accelerates the screening of epididymis‐enriched genes for potential functions in reproduction. (Source: Andrology)
Source: Andrology - March 29, 2019 Category: Urology & Nephrology Authors: T. Noda, N. Sakurai, K. Nozawa, S. Kobayashi, D. J. Devlin, M. M. Matzuk, M. Ikawa Tags: Original Article Source Type: research

Epigenetic treatment combinations to effectively target cisplatin ‐resistant germ cell tumors‐past, present, and future considerations
ConclusionEpigenetic (combination) treatment for germ cell tumors should be further explored in pre ‐clinical and clinical research for its potential to further improve germ cell tumor treatment. (Source: Andrology)
Source: Andrology - March 29, 2019 Category: Urology & Nephrology Authors: C. Oing, M. A. Skowron, C. Bokemeyer, D. Nettersheim Tags: Review Article Source Type: research

A quantitative global proteomics approach to understanding the functional pathways dysregulated in the spermatozoa of asthenozoospermic testicular cancer patients
AbstractBackgroundTesticular cancer (TC) is the most common cancer diagnosed in men of reproductive age group. Sperm banking is recommended in these patients prior to cancer treatment. There is no literature describing the proteins dysregulated in the spermatozoa of TC patients with poor motility.ObjectiveThe primary objective of this study was to compare the differences in the sperm proteome of normozoospermic (motility  >  40%) and asthenozoospermic (motility 
Source: Andrology - March 29, 2019 Category: Urology & Nephrology Authors: M. K. Panner Selvam, A. Agarwal, P. N. Pushparaj Tags: Original Article Source Type: research

Humanin levels in human seminal plasma and spermatozoa are related to sperm quality
AbstractBackgroundHumanin has reportedly been expressed in testis and spermatozoa, but no study has yet reported its presence in human seminal plasma (SP).ObjectiveThe aim of this study was to investigate the presence of humanin in human SP and to determine the correlation between humanin levels in SP/spermatozoa and sperm quality.Materials and methodsSemen samples for SP/sperm humanin level measurement were collected from 164 patients who attended our andrology clinic for fertility evaluation. The localization of humanin in spermatozoa was evaluated using an immunofluorescence method, and SP/sperm humanin levels were meas...
Source: Andrology - March 28, 2019 Category: Urology & Nephrology Authors: M. Rao, Z. Wu, Y. Wen, R. Wang, S. Zhao, L. Tang Tags: Original Article Source Type: research

Immunolocalization of DMRTB1 in human testis with normal and impaired spermatogenesis
ConclusionOur data indicate a relevant role for DMRTB1 regarding the entry of spermatogonia into meiosis in men. (Source: Andrology)
Source: Andrology - March 28, 2019 Category: Urology & Nephrology Authors: E. Hilbold, M. Bergmann, D. Fietz, S. Kliesch, W. Weidner, M. Langeheine, K. Rode, R. Brehm Tags: Original Article Source Type: research

Detection of protamine 2 in bovine spermatozoa and testicles
AbstractBackgroundSperm DNA integrity is crucial for transmission of genetic information to future generations and DNA damage can occur during chromatin packaging. Chromatin packaging involves the replacement of somatic nucleosomal histones by nuclear proteins called protamines. Protamine 1 (PRM1) is transcribed and translated in spermatids of all mammals; however, protamine 2 (PRM2) is transcribed in low levels in spermatids and it is not yet described in bull mature spermatozoa.ObjectivesThe aim of this study was to assess gene and protein expression of PRM2 and corroborate gene and protein expression of PRM1 in bull spe...
Source: Andrology - March 28, 2019 Category: Urology & Nephrology Authors: T. R. S. Hamilton, R. Sim ões, C. M. Mendes, M. D. Goissis, E. Nakajima, E. A. L. Martins, J. A. Visintin, M. E. O. A. Assumpção Tags: Original Article Source Type: research

A new system of sperm cryopreservation: evaluation of survival, motility, DNA oxidation, and mitochondrial activity
This study aimed to compare the new system of V with conventional freezing (CF) protocol using fresh spermatozoa as reference (C).Material and methodsProspective cohort study. A total of 47 sperm samples from men attending the infertility clinic at Instituto Valenciano de Infertilidad Valencia. The sperm V solution was 0.3 M trehalose –sucrose and plunged directly in liquid nitrogen in microdroplets of 5–10 lL, using a new system collector of V. Sperm viability indicators such as sperm motility, vitality rates, mitochondrial function, and sperm DNA oxidation were assessed before and after cryopreservation. Sper...
Source: Andrology - March 27, 2019 Category: Urology & Nephrology Authors: D. Pab ón, M. Meseguer, G. Sevillano, A. Cobo, J. L. Romero, J. Remohí, M. J. de los Santos Tags: Original Article Source Type: research

Disruption of bovine sperm functions in the presence of aplastic midpiece defect
AbstractBackgroundBulls are of great importance in the productive chain and for this reason they should have a good semen quality. There is no doubt that sperm morphology is very important to bull fertility, although little is known about how exactly the abnormal morphologies may affect sperm functions.ObjectivesTo detail the morphological description of the aplastic midpiece defect (AMD), as well as to understand its consequences for male fertility based on membrane and acrosome status, mitochondrial membrane potential and DNA integrity parameters.Materials and methodsThe bulls were divided into two groups: control, consi...
Source: Andrology - March 25, 2019 Category: Urology & Nephrology Authors: E. A. D íaz‐Miranda, P. P. Maitan, T. P. Machado, B. S. Camilo, D. A. Lima, D. S. Okano, J. M. Penitente‐Filho, M. Machado‐Neves, L. L. Oliveira, S. E. F. Guimarães, E. P. Costa, J. D. Guimarães Tags: Original Article Source Type: research

N6 ‐Methyladenosine detected in RNA of testicular germ cell tumors is controlled by METTL3, ALKBH5, YTHDC1/F1/F2, and HNRNPC as writers, erasers, and readers
ConclusionIn summary, our data provide the starting point for further experiments deciphering the role of 6mA in the RNA of GCTs. (Source: Andrology)
Source: Andrology - March 23, 2019 Category: Urology & Nephrology Authors: D. Nettersheim, D. Berger, S. Jostes, G. Kristiansen, G. Lochnit, H. Schorle Tags: Original Article Source Type: research

New insights into germ cell tumor genomics
ConclusionMolecular characterization of GCT patients may provide biologic rationale for novel treatment options in patients with platinum ‐resistant disease. (Source: Andrology)
Source: Andrology - March 21, 2019 Category: Urology & Nephrology Authors: J.T. Lafin, A. Bagrodia, S. Woldu, J. F. Amatruda Tags: Review Article Source Type: research

Abstracts from the American Society of Andrology 44th Annual Conference
Andrology, Volume 7, Issue S1, Page 1-110, March 2019. (Source: Andrology)
Source: Andrology - March 20, 2019 Category: Urology & Nephrology Tags: Abstracts from the American Society of Andrology 44th Annual Conference Source Type: research

Sperm functional aspects and enriched proteomic pathways of seminal plasma of adult men with obesity
Conclusionmolecular pathways suggest there is a causative link, and that the effector mechanisms alter sperm metabolic status and defective testicular selection 5 mechanisms. (Source: Andrology)
Source: Andrology - March 19, 2019 Category: Urology & Nephrology Authors: P. C. Ferigolo, M. B. Ribeiro de Andrade, M. Camargo, V. M. Carvalho, K. H. M. Cardozo, R. P. Bertolla, R. Fraietta Tags: Original Article Source Type: research

Issue Information
Andrology, Volume 7, Issue 2, Page i-iii, March 2019. (Source: Andrology)
Source: Andrology - March 18, 2019 Category: Urology & Nephrology Tags: Issue Information Source Type: research

Associations between major dietary patterns and testicular function in a population ‐based cohort of young men: results from the Western Australian Pregnancy Cohort (Raine) Study
ConclusionsA potential negative association of a “Western” dietary pattern with male reproductive health was detected and should be studied further in population‐based studies. (Source: Andrology)
Source: Andrology - March 10, 2019 Category: Urology & Nephrology Authors: M. Ognjenovic, G. L. Ambrosini, E. Malacova, D. A. Doherty, W.  H. Oddy, D. J. Handelsman, R. McLachlan, J. Dickinson, R. J.  Hart Tags: Review Article Source Type: research

Testosterone replacement in congenital hypogonadotropic hypogonadism maintains bone density but has only limited osteoanabolic effects
AbstractBackgroundCongenital hypogonadotropic hypogonadism (CHH) is a rare condition characterized by complete sex steroid deficiency. Therefore, CHH is a unique human model to study the impact of long ‐term testosterone replacement therapy (TRT) on bone.ObjectiveIn this single ‐center retrospective observational study, we assessed the long‐term impact of TRT on femoral and lumbar bone mineral density (BMD) in adult CHH men.MethodsA total of 25 patients with CHH were included. Femoral and lumbar BMD was assessed by dual ‐energy X‐ray absorptiometry (DEXA) and reported as T‐scores. In six patients (treatment‐n...
Source: Andrology - March 8, 2019 Category: Urology & Nephrology Authors: L. Antonio, S. Caerels, F. Jardi, E. Delaunay, D. Vanderschueren Tags: Original Article Source Type: research

Expanding the phenotypic and genetic spectrum of Chinese patients with congenital absence of vas deferens bearing CFTR and ADGRG2 alleles
ConclusionThis study illustrates the significance of all exon sequencing inCFTR andADGRG2. A picture of the genetic spectrum of Chinese CAVD patients and the most common mutations can be described, which are different from Caucasian cohorts and Chinese CF patients. (Source: Andrology)
Source: Andrology - February 27, 2019 Category: Urology & Nephrology Authors: P. Yuan, Z. K. Liang, H. Liang, L. Y. Zheng, D. Li, J. Li, J. Zhang, J. Tian, L. H. Lai, K. Zhang, Z. Y. He, Q. X. Zhang, W. J. Wang Tags: Original Article Source Type: research

AMH and INSL3 in testicular and extragonadal pathophysiology: what do we know?
ConclusionAnti ‐Müllerian hormone and INSL3 are markers of Sertoli and Leydig cells maturation, respectively, usually involved in the pathogenesis of disorders of sexual differentiation. However, their role in testicular pathology has only been hinted at in the last decades. Recent evidence supports an involvem ent of both anti‐Müllerian hormone and INSL3 in extragonadal pathophysiology as well. (Source: Andrology)
Source: Andrology - February 22, 2019 Category: Urology & Nephrology Authors: A. Sansone, S. Kliesch, A. M. Isidori, S. Schlatt Tags: Review Article Source Type: research

Phosphorylation of GATA4 serine 105 but not serine 261 is required for testosterone production in the male mouse
The objective of the present study is to characterize the endogenous role of GATA4 S105 and S261 phosphorylation in the mouse testis.Materials and methodsWe examined both previously described GATA4 S105A mice and a novel GATA4 S261A knock ‐in mouse that we generated by CRISPR/Cas9 gene editing. The male phenotype of the mutants was characterized by assessing androgen‐dependent organ weights, hormonal profiles, and expression of multiple testicular target genes using standard biochemical and molecular biology techniques.ResultsThe fecundity of crosses between GATA4 S105A mice was reduced but without a change in sex rati...
Source: Andrology - February 22, 2019 Category: Urology & Nephrology Authors: Francis Bergeron, Alain Boulende Sab, Marie France Bouchard, Hiroaki Taniguchi, Ouliana Souchkova, Catherine Brousseau, Jacques J. Tremblay, Nicolas Pilon, Robert S. Viger Tags: Original Article Source Type: research

In vitro aging of boar spermatozoa: role of sperm proximity and seminal plasma
AbstractBackgroundKnowledge on the effect of seminal plasma on sperm function in extended semen during in  vitro storage is lacking.ObjectivesThe aim was to examine the interactive role of sperm concentration and seminal plasma concentration on boar sperm function during in  vitro aging.Material and methodsExperiment 1: Twenty ‐one boar ejaculates were aliquoted with Beltsville Thawing Solution into five semen doses containing between 32.5 and 8.5 × 106 sperm/mL. Experiment 2: Semen samples (n = 8) containing 18 × 106 or 10  × 106 sperm/mL with...
Source: Andrology - February 21, 2019 Category: Urology & Nephrology Authors: A. ‐M. Luther, D. Waberski Tags: Original Article Source Type: research

Genitourinary cancer patients have worse baseline semen parameters than healthy sperm bankers
AbstractBackgroundWhile the spermatotoxic properties of cancer treatments such as chemotherapy and radiation therapy are widely recognized, the effect of malignancy itself on male fertility is not clearly understood.ObjectivesTo determine whether malignancy is associated with diminished semen quality prior to spermatotoxic treatment among sperm bankers.Materials and MethodsRetrospective database review of de ‐identified records was obtained for all episodes of sperm banking performed at a cryobank from January 2004 to May 2017 for one of the following reasons: ‘future use’ (e.g., military deployment and gende...
Source: Andrology - February 20, 2019 Category: Urology & Nephrology Authors: R. Xu, G. M. Centola, C. Tanrikut Tags: Original Article Source Type: research

Alpha lipoic acid reverses the negative effect of LPS on mouse spermatozoa and developmental competence of resultant embryos in  vitro
ConclusionThese in  vitro findings suggested a therapeutic role for ALA in reducing the negative effects of LPS on spermatozoa and early embryonic development. (Source: Andrology)
Source: Andrology - February 20, 2019 Category: Urology & Nephrology Authors: A. Makvandi, R. Kowsar, M. Hajian, A. H. Mahdavi, N. Tanhaei Vash, M. H. Nasr ‐Esfahani Tags: Original Article Source Type: research

Gods associated with male fertility and virility
ConclusionGods of male fertility and virility played important roles in many ancient cultures. Offerings and rituals to these gods were the only available options to deal with problems of reproduction and demonstrate the lengths to which ancient people would go seeking cures for infertility. (Source: Andrology)
Source: Andrology - February 20, 2019 Category: Urology & Nephrology Authors: F. T. L. Neto, P. V. Bach, R. J. L. Lyra, J. C. Borges Junior, G. T. d. S. Maia, L. C. N. Araujo, S. V. C. Lima Tags: Review Article Source Type: research

Increase of germ cell nuclear factor expression in globozoospermic Gopc −/− knockout mice
ConclusionGopc−/− mice have defective acrosome and manchette. The manchette is involved in the transport of proteins through the cytoplasm and the nucleus. Considering that the GCNF protein is normally transported to the acrosome and the nucleus, it can be thought that transport deficiencies inGopc−/− mice are responsible for the increased expression of this protein. (Source: Andrology)
Source: Andrology - February 20, 2019 Category: Urology & Nephrology Authors: M. Bizkarguenaga, L. Gomez ‐Santos, J. F. Madrid, F. J. Sáez, E. Alonso Tags: Original Article Source Type: research

Cellular origin of microRNA ‐371a‐3p in healthy males based on systematic urogenital tract tissue evaluation
ConclusionsThe observation is important in the context of applying miR ‐371a‐3p as molecular liquid biopsy biomarker for diagnosis and follow‐up of patients with malignant (T)GCT. Moreover, miR‐371a‐3p might be an informative seminal biomarker for testicular germ cell composition. (Source: Andrology)
Source: Andrology - February 20, 2019 Category: Urology & Nephrology Authors: W. P. A. Boellaard, A. J. M. Gillis, G. J. L. H. Leenders, H. Stoop, T. Agthoven, L. C. J. Dorssers, M. Dinkelman ‐Smit, J. L. Boormans, L. H. J. Looijenga Tags: Original Article Source Type: research

Expression of phospholipase PLC Zeta in human spermatozoa: impact of cryopreservation
AbstractBackgroundCryopreservation is used for infertility treatment and for fertility preservation. The results of the use of frozen spermatozoa for ART (Assisted Reproductive Technology) are lower than those of fresh spermatozoa. The phospholipase C Zeta (PLC ζ) protein is involved in oocyte activation.ObjectivesThe aim of this study was to compare the percentage of spermatozoa expressing phospholipase C Zeta protein before and after a frozen ‐thawing cycle.Materials and methodsSamples were provided after at least 2  days of sexual abstinence. A part of the fresh ejaculate (200 μL) was recovered for t...
Source: Andrology - February 19, 2019 Category: Urology & Nephrology Authors: J. Moreau, S. Fargeon, N. Gatimel, J. Parinaud, R. D. L éandri Tags: Short Communication Source Type: research

The relationship between cannabis and male infertility, sexual health, and neoplasm: a systematic review
ConclusionStudies of the effects of cannabis suggest impact on urologic health and disease. Prospective, long ‐term studies are necessary for further elucidation of these effects. (Source: Andrology)
Source: Andrology - February 15, 2019 Category: Urology & Nephrology Authors: S. Rajanahally, O. Raheem, M. Rogers, W. Brisbane, K. Ostrowski, T. Lendvay, T. Walsh Tags: Review Article Source Type: research

Endogenous circulating testosterone and sex hormone ‐binding globulin levels and measures of myocardial structure and function: the Framingham Heart Study
ConclusionsNeither testosterone nor sex hormone ‐binding globulin levels in men are associated significantly with myocardial mass and function independent of established cardiovascular risk factors. (Source: Andrology)
Source: Andrology - February 13, 2019 Category: Urology & Nephrology Authors: K. M. Pencina, T. G. Travison, S. Bhasin, Z. Li, N. Nigam, W. J. Manning, R. S. Vasan, U. Hoffmann, C. J. O'Donnell, S. Basaria Tags: Original Article Source Type: research

Issue Information
Andrology, Volume 7, Issue 1, Page i-iii, January 2019. (Source: Andrology)
Source: Andrology - February 7, 2019 Category: Urology & Nephrology Tags: Issue Information Source Type: research

Welcome to the Chinese version of Andrology!
Andrology, Volume 7, Issue 1, Page 1-1, January 2019. (Source: Andrology)
Source: Andrology - February 7, 2019 Category: Urology & Nephrology Authors: M. Simoni, D. T. Carrell Tags: Editorial Source Type: research

European Academy of Andrology Newsletter (Edition December 2018)
Andrology, Volume 7, Issue 1, Page 124-130, January 2019. (Source: Andrology)
Source: Andrology - February 7, 2019 Category: Urology & Nephrology Authors: Ewa Rajpert ‐De Meyts, Csilla Krausz Tags: Newsletter Source Type: research

ICSI outcomes using testicular spermatozoa in non ‐azoospermic couples with recurrent ICSI failure and no previous live births
AbstractBackgroundThe use of testicular over ejaculated spermatozoa for ICSI has been presented as an alternative to overcome infertility in men with poor semen parameters or high levels of sperm DNA fragmentation.ObjectiveTo evaluate the efficacy of testicular ICSI outcomes in couples with no previous live birth and recurrent ICSI failure using ejaculated spermatozoa by comparison to the outcomes of couples with similar history of recurrent ICSI using ejaculated spermatozoa only.Materials and MethodsA total of 145 couples undergoing ejaculated or testicular ICSI cycles with no previous live births and with at least two pr...
Source: Andrology - February 7, 2019 Category: Urology & Nephrology Authors: M. B. Herrero, M. F. Lusignan, W. ‐Y. Son, M. Sabbah, W.  Buckett, P. Chan Tags: Original Article Source Type: research

Vasectomy and the risk of prostate cancer in a prospective US Cohort: Data from the NIH ‐AARP Diet and Health Study
Conclusions were similar when using pro pensity adjustment and matching. Importantly, a significant interaction between vasectomy and PSA screening was identified.DiscussionEstimates of the association between vasectomy and prostate cancer are sensitive to analytic method underscoring the tenuous nature of the connection. Given the differences between men who do and do not utilize vasectomy, selection bias appears likely to explain any identified association between vasectomy and prostate cancer.ConclusionsWith over 20  years of follow‐up, no convincing relationship between vasectomy and prostate cancer of any grade...
Source: Andrology - February 3, 2019 Category: Urology & Nephrology Authors: M. T. Davenport, C. A. Zhang, J. T. Leppert, J. D. Brooks, M. L. Eisenberg Tags: Original Article Source Type: research

The association between serum total testosterone and progression of hyperglycemia: a 15 ‐year prospective cohort study
ConclusionLow testosterone concentrations in men are associated with progression from normoglycemia to pre ‐diabetes, but not from pre‐diabetes to diabetes. (Source: Andrology)
Source: Andrology - January 21, 2019 Category: Urology & Nephrology Authors: S. Minooee, F. Ramezani Tehrani, M. Rahmati, S. Amanollahi Soudmand, M. Tohidi, Z. Sabet, F. Azizi Tags: Original Article Source Type: research

The epididymal amyloid matrix: structure and putative functions
ConclusionTogether, these results suggest the amyloid matrix serves important roles in epididymal function including sperm maturation and protection. (Source: Andrology)
Source: Andrology - January 20, 2019 Category: Urology & Nephrology Authors: G. A. Cornwall, H. Q. Do, A. Hewetson, A. Muthusubramanian, C. Myers Tags: Review Article Source Type: research

The puzzling incidence of testicular cancer in New Zealand: what can we learn?
ConclusionThis review examines the possible drivers of our observed disparity, discusses their feasibility, and highlights new work that is underway to further understand these drivers. (Source: Andrology)
Source: Andrology - January 20, 2019 Category: Urology & Nephrology Authors: J. K. Gurney Tags: Review Article Source Type: research

Mediterranean diet and the risk of poor semen quality: cross ‐sectional analysis of men referring to an Italian Fertility Clinic
AbstractBackgroundSeveral diet patterns have been suggested as involved in processes of spermatogenesis and thus in male subfertility. To study the relation between Mediterranean diet and abnormal sperm parameters in men of subfertile couples, we performed a cross ‐sectional analysis of baseline data from a prospective cohort study.MethodsPatients were enrolled in an Italian Fertility Clinic. Couples undergoing assisted reproduction techniques (ART) were interviewed to obtain information on personal and health history, lifestyle habits, and diet, on the day of oocyte retrieval. On the same day, a semen sample was also co...
Source: Andrology - January 20, 2019 Category: Urology & Nephrology Authors: E. Ricci, F. Bravi, S. Noli, S. Ferrari, V. De Cosmi, I. La Vecchia, M. Cavadini, C. La  Vecchia, F. Parazzini Tags: Original Article Source Type: research

Human sperm DNA damage has an effect on immunological interaction between spermatozoa and fallopian tube
Discussion and conclusionDamage ‐associated molecular patterns from DNA damage activate TLR signaling pathway in human fallopian tubes and result in the upregulation of inflammatory cytokines and chemokines. This situation may provide pathologic environment for capacitation, fertilization, embryo development, and implantation in female reproductive tract and can be one of the mechanisms of infertility in men with high DF. (Source: Andrology)
Source: Andrology - January 20, 2019 Category: Urology & Nephrology Authors: Z. Zandieh, M. Ashrafi, K. Aflatoonian, R. Aflatoonian Tags: Original Article Source Type: research

E2F1 copy number variations contribute to spermatogenic impairment and cryptorchidism by increasing susceptibility to heat stress
ConclusionThis study shows a link betweenE2F1CNV and male infertility, suggesting that the increased risk of spermatogenic impairment associated with higherE2F1 copies might be due to higher susceptibility to stressful conditions. (Source: Andrology)
Source: Andrology - January 18, 2019 Category: Urology & Nephrology Authors: M. S. Rocca, A. Di Nisio, I. Sabovic, M. Ghezzi, C. Foresta, A. Ferlin Tags: Original Article Source Type: research