Late onset hypogonadism (LOH): Prostate safety
ConclusionTRT could be considered for most men with LOH regardless of their history of prostate disease. However, a discussion about the risks and benefits of TRT is always advised, especially in men with PCa. Appropriate monitoring is mandatory. (Source: Andrology)
Source: Andrology - February 14, 2020 Category: Urology & Nephrology Authors: Eduardo P. Miranda, Luiz Ot ávio Torres Tags: REVIEW ARTICLE Source Type: research

Validation of Ultrasound Biomicroscopy for the Assessment of Xenogeneic Testis Tissue Grafts and Cell Implants in Recipient Mice
AbstractBackgroundSubcutaneous grafting/implantation of neonatal testis tissue/cells from diverse donor species into recipient mice can be used as anin vivo model to study testis development, spermatogenesis, and steroidogenesis. Ultrasound biomicroscopy (UBM) allows obtaining high definition cross ‐sectional images of tissues at microscopic resolutions.ObjectivesThe present study was designed to 1) validate the use of UBM for non ‐invasive monitoring of grafts/implants over‐time, and to 2) correlate UBM findings with the morphological attributes of recovered grafts/implants.Materials and methodsTestis tissue fragmen...
Source: Andrology - February 7, 2020 Category: Urology & Nephrology Authors: Mohammad Amin Fayaz, Awang Hazmi Awang ‐Junaidi, Jaswant Singh, Ali Honaramooz Tags: ORIGINAL ARTICLE Source Type: research

European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males
ConclusionTRT can reliably improve global sexual function in men with hypogonadism in the short term. Long ‐term clinical benefits, and safety of TRT in functional hypogonadism, remain to be fully documented. Clinicians should therefore explicitly discuss the uncertainties and benefits of TRT and engage them in shared management decision‐making. (Source: Andrology)
Source: Andrology - February 6, 2020 Category: Urology & Nephrology Authors: Giovanni Corona, Dimitrios G. Goulis, Ilpo Huhtaniemi, Michael Zitzmann, Jorma Toppari, Gianni Forti, Dirk Vanderschueren, Frederick C. Wu Tags: REVIEW ARTICLE Source Type: research

Genetic Diagnosis and Sperm Retrieval Outcomes for Chinese Patients with Congenital Bilateral Absence of Vas Deferens
In this study, we aimed to study the mutation spectrum ofCFTR andADGRG2 in a group of CBAVD patients and to evaluate sperm retrieval outcomes in a subset of CBAVD patients.Materials and methodsNext ‐generation targeted sequencing was used to identify mutations in theCFTR andADGRG2 genes in 38 CBAVD patients. In addition, we followed and analyzed nine of the 38 patients who were undergoing sperm retrieval surgery.ResultsIn total, 27 of 38 (71.05%) patients carried at least one likely pathogenic or pathogenic mutation inCFTR orADGRG2. In addition to the IVS9 ‐5T allele, 15CFTR and 1ADGRG2 mutations were identified, inclu...
Source: Andrology - February 5, 2020 Category: Urology & Nephrology Authors: Hongxiang Wang, Miao An, Yidong Liu, Kai Hu, Yan Jin, Shiran Xu, Bin Chen, Mujun Lu Tags: ORIGINAL ARTICLE Source Type: research

Protective effect of Berberine on reproductive function and spermatogenesis in diabetic rats via inhibition of ROS/JAK2/NF κB pathway
ConclusionROS/JAK2/NF κB pathway is involved in the DM‐induced low reproductive function and impaired spermatogenesis. BB can play a protective role in preserving the reproductive function and spermatogenesis in DM by inhibiting ROS/JAK2/NFκB pathway. (Source: Andrology)
Source: Andrology - February 3, 2020 Category: Urology & Nephrology Authors: Jingyu Song, Xintao Gao, Zhe Tang, Hao Li, Yajun Ruan, Zhuo Liu, Tao Wang, Shaogang Wang, Jihong Liu, Hongyang Jiang Tags: ORIGINAL ARTICLE Source Type: research

Sperm retrieval rates in non ‐mosaic Klinefelter patients undergoing testicular sperm extraction: what expectations do we have in the real‐life setting?
ConclusionsIn the real ‐life setting we observed a lower SRR (21.4%) than that reported in meta‐analyses in our cohort of KS patients. No associations between clinical, hormonal and procedural variables with TESE success were found. (Source: Andrology)
Source: Andrology - January 30, 2020 Category: Urology & Nephrology Authors: Luca Boeri, Franco Palmisano, Mirko Preto, Mattia Sibona, Paolo Capogrosso, Alessandro Franceschelli, Eduard Ruiz ‐Castañé, Joaquim Sarquella‐Geli, Lluís Bassas‐Arnau, Fabrizio Ildefonso Scroppo, Antonino Saccà, Giorgio Gentile, Marc Tags: ORIGINAL ARTICLE Source Type: research

The physician's gender influences the results of the diagnostic workup for erectile dysfunction
ConclusionsPhysician's gender affects the results obtained during the erectile dysfunction diagnostic workup. Men interviewed by a female physician describe a less severe erectile dysfunction probably as attempt to defend their own virility. On the other hand, the presence of a male physician during intracavernousal injection test is associated to a worse response suggesting a possible unconscious competition. (Source: Andrology)
Source: Andrology - January 29, 2020 Category: Urology & Nephrology Authors: Giulia Rastrelli, Sarah Cipriani, Andrea Craparo, Sara De Vincentis, Antonio R. M. Granata, Giorgia Spaggiari, Manuela Simoni, Mario Maggi, Daniele Santi Tags: ORIGINAL ARTICLE Source Type: research

Late ‐Onset Hypogonadism and Lifestyle‐Related Metabolic Disorders
ConclusionsEmerging new evidence suggests that metabolic disorders may aggravate LOH effects on the fertility potential of males in reproductive age, by enhancing T deficiency. These results clearly show that metabolic disorders, such as obesity and diabetes, have a greater impact on causing hypogonadotropic hypogonadism than tissue senescence. Further, TRT and off ‐label alternatives capable of restoring T levels appear as suitable to improve LOH, while also counteracting comorbidities related with metabolic diseases. (Source: Andrology)
Source: Andrology - January 28, 2020 Category: Urology & Nephrology Authors: Patr ícia C. Braga, Sara C. Pereira, João P. Ribeiro, Mário Sousa, Mariana P. Monteiro, Pedro F. Oliveira, Marco G. Alves Tags: REVIEW ARTICLE Source Type: research

Celebrating the Silver Anniversary of the North American Testis Workshop
ConclusionDuring the first twenty ‐five meetings of the NATW, a remarkable number of breakthroughs regarding every aspect of the testis were presented. We anticipate that with the acceleration of new genetic, epigenetic, and molecular knowledge of the functions of testicular cells, we will continue to learn about the discovery of new and clinically important aspects of testicular function during the next twenty‐five NATWs. (Source: Andrology)
Source: Andrology - January 22, 2020 Category: Urology & Nephrology Authors: Bernard Robaire, Mitch Eddy, Erwin Goldberg, Michael Griswold, Leslie Heckert, John McCarrey, Marie ‐Claire Orgebin‐Crist, Vassilios Papadopoulos, Jacquetta Trasler, William Wright, Wei Yan, Barry Zirkin Tags: REVIEW ARTICLE Source Type: research

Restoration of Erectile Function by Suppression of Corporal Apoptosis and Oxidative Stress with Losartan in Aged Rats with Erectile Dysfunction
ConclusionsOur results indicated that administration of losartan not merely restored erectile function, but also significantly prevented corporal apoptosis and oxidative stress in AED by suppressing the Akt/Bad/Bax/Caspase ‐3 and Nrf2/Keap‐1 pathways. (Source: Andrology)
Source: Andrology - January 22, 2020 Category: Urology & Nephrology Authors: Yi Wang, Yamin Wang, Rong Cong, Ye Tian, Chen Chen, Yichun Wang, Qijie Zhang, Xiang Zhou, Chengjian Ji, Xianghu Meng, Ninghong Song Tags: ORIGINAL ARTICLE Source Type: research

Simvastatin alleviated diabetes mellitus ‐induced erectile dysfunction in rats by enhancing AMPK pathway‐induced autophagy
AbstractBackgroundDiabetes mellitus ‐induced erectile dysfunction (DMED) is a common diabetic complication, and new therapeutics and the pathogenesis of DMED need to be investigated.ObjectivesThe aim was to investigate the pathogenesis of DMED and the pharmacological mechanism of simvastatin treatment in DMED model rats.Materials and methodsA total of 86 male Sprague ‐Dawley (SD) rats aged 8 weeks old were used in this study. The rats were divided into 3 groups: control (normal), DMED (streptozotocin (STZ) ‐injected), and DMED+simvastatin (sim). Each group was subdivided into 2 subgroups forin vitro andin vivo analys...
Source: Andrology - January 18, 2020 Category: Urology & Nephrology Authors: Fan Ding, Changyu Shan, Hongwei Li, Yuping Zhang, Chunling Guo, Zhansong Zhou, Ji Zheng, Wenhao Shen, Qiang Dai, Qin Ouyang, Xiaojun Wu Tags: ORIGINAL ARTICLE Source Type: research

The physician ’s gender influences the results of the diagnostic workup for erectile dysfunction
ConclusionsPhysician ’s gender affects the results obtained during the ED diagnostic workup. Men interviewed by a female physician describe a less severe ED probably as attempt to defend their own virility. On the other hand, the presence of a male physician during ICI test is associated to a worse response suggesting a possible unconscious competition. (Source: Andrology)
Source: Andrology - January 18, 2020 Category: Urology & Nephrology Authors: Giulia Rastrelli, Sarah Cipriani, Andrea Craparo, Sara De Vincentis, Antonio RM Granata, Giorgia Spaggiari, Manuela Simoni, Mario Maggi, Daniele Santi Tags: ORIGINAL ARTICLE Source Type: research

In vitro exposure to metformin activates human spermatozoa at therapeutically relevant concentrations
AbstractBackgroundMetformin, a drug used to treat type 2 diabetes, has gained attention for its multiple therapeutic applications. However, little is known about its effects on human sperm function at therapeutically relevant concentration.ObjectivesThe aim of this study was to elucidate the in vitro actions of metformin on human sperm function and explore the underlying mechanism of any effects.Materials and methodsHuman ejaculated spermatozoa were treated with therapeutically relevant concentrations (0.25, 5, 10, 20, 40 and 80  µM) of metformin in vitro. Fertilization‐essential functions of spermatozoa were ...
Source: Andrology - January 15, 2020 Category: Urology & Nephrology Authors: Yuan Yang, Houyang Chen, Shiqi Weng, Tingting Pan, Wenqiong Chen, Fang Wang, Tao Luo, Yuxin Tang Tags: ORIGINAL ARTICLE Source Type: research

In ‐vitro spermatogenesis through testis modelling: Toward the generation of testicular organoids
ConclusionFurther improvements in culture methodology and medium composition have to be made before being able to provide both testicular tubulogenesis and spermatogenesis in ‐vitro. (Source: Andrology)
Source: Andrology - January 9, 2020 Category: Urology & Nephrology Authors: Guillaume Richer, Yoni Baert, Ellen Goossens Tags: REVIEW ARTICLE Source Type: research

Weight loss more than glycemic control may improve testosterone in obese type 2 diabetes mellitus men with hypogonadism
AbstractBackgroundFunctional hypogonadism is a common disorder among patients with obesity and type 2 diabetes mellitus (T2DM) and could be managed by first treating the underlying causes.ObjectiveThe present study was undertaken to investigate the contribution of body weight and glycemic control to the reversibility of hypogonadism to eugonadism in a real ‐life setting.Materials and methodsAdult obese male patients with uncontrolled T2DM, complaining of mild to moderate erectile dysfunction (ED) and suspected of functional hypogonadism evaluated at our institution from 2015 to 2017 were retrospectively included. The gon...
Source: Andrology - January 9, 2020 Category: Urology & Nephrology Authors: Vito Angelo Giagulli, Marco Castellana, Matteo Domenico Carbone, Carla Pelusi, Maria Isabella Ramunni, Giovanni De Pergola, Edoardo Guastamacchia, Vincenzo Triggiani Tags: ORIGINAL ARTICLE Source Type: research

Lycopene attenuates chronic prostatitis/chronic pelvic pain syndrome by inhibiting oxidative stress and inflammation via the interaction of NF ‐κB, MAPKs, and Nrf2 signaling pathways in rats
ConclusionsThe findings in this study suggest that lycopene exerts potent anti ‐ CP/CPPS effects through alleviating inflammatory response and oxidative stress, which is probably attributed to the interaction of NF‐κB, MAPKs, and Nrf2 signaling pathways in rats. As a natural antioxidant, lycopene may serve as a promising pharmaceutical preparation for treating CP/CPPS. (Source: Andrology)
Source: Andrology - January 7, 2020 Category: Urology & Nephrology Authors: Qinxin Zhao, Feiya Yang, Lingquan Meng, Dong Chen, Mingshuai Wang, Xinxing Lu, Dexi Chen, Yongguang Jiang, Nianzeng Xing Tags: ORIGINAL ARTICLE Source Type: research

Periovulatory oviductal fluid decreases sperm protein kinase A activity, tyrosine phosphorylation, and in vitro fertilization in pig
ConclusionOF from follicular, early luteal, and periovulatory phases of the estrous cycle modulates the sperm protein phosphorylation as well as the acrosome reaction involved in capacitation and increases monospermic fertilization in in vitro fertilization. Our findings suggest that fluids from the female reproductive tract could be used as additives in porcine IVF systems to modulate sperm ‐oocyte interaction. (Source: Andrology)
Source: Andrology - January 7, 2020 Category: Urology & Nephrology Authors: H éctor Zapata‐Carmona, Cristina Soriano‐Úbeda, Evelyne París‐Oller, Carmen Matás Tags: ORIGINAL ARTICLE Source Type: research

Use of follicle ‐stimulating hormone for the male partner of idiopathic infertile couples in Italy: Results from a multicentre, observational, clinical practice survey
AbstractBackgroundThe management of male idiopathic infertility is heterogeneous. Although meta ‐analyses reported the effectiveness on pregnancy rate, the real clinical impact of follicle‐stimulating hormone (FSH) was not evaluated so far. In Italy, FSH is approved by the National Medicines Agency (AIFA) for idiopathic infertile patients with FSH 18  years and FSH serum levels
Source: Andrology - January 7, 2020 Category: Urology & Nephrology Authors: Daniele Santi, Sara De Vincentis, Patrizia Alfano, Giancarlo Balercia, Aldo E. Calogero, Francesco Cargnelutti, Maria Elisabetta Coccia, Rosita A. Condorelli, Alessandro Dal Lago, Cristina De Angelis, Mariagrazia Gallo, Nicola Iannantuoni, Fra Tags: ORIGINAL ARTICLE Source Type: research

The preconception environment and sperm epigenetics
AbstractBackgroundInfertility is a common reproductive disorder, with male factor infertility accounting for approximately half of all cases. Taking a paternal perceptive, recent research has shown that sperm epigenetics, such as changes in DNA methylation, histone modification, chromatin structure, and non ‐coding RNA expression, can affect reproductive and offspring health. Importantly, environmental conditions during the preconception period has been demonstrated to shape sperm epigenetics.AimTo provide an overview on epigenetic modifications that regulate normal gene expression and epigenetic remodeling that occurs d...
Source: Andrology - January 4, 2020 Category: Urology & Nephrology Authors: Chelsea Marcho, Oladele A. Oluwayiose, J. Richard Pilsner Tags: REVIEW ARTICLE Source Type: research

Increased DNA methylation in the spermatogenesis ‐associated (SPATA) genes correlates with infertility
AbstractBackgroundSpermatogenesis ‐associated (SPATA) family of genes plays important roles in spermatogenesis, sperm maturation or fertilization. The knockout studies in mice have demonstrated that SPATA genes are crucial for fertility. Gene expression and genetic polymorphism studies have further suggested their correlation with infertility; however, methylation analysis of SPATA genes in human male infertility has not yet been undertaken.ObjectivesTo analyze the methylation status of SPATA4, SPATA5 and SPATA6 genes in oligozoospermic male infertility.Materials and methodsIn the present study, we have analyzed DNA meth...
Source: Andrology - January 2, 2020 Category: Urology & Nephrology Authors: Kumar Mohanty Sujit, Vertika Singh, Sameer Trivedi, Kiran Singh, Gopal Gupta, Singh Rajender Tags: ORIGINAL ARTICLE Source Type: research

Re: Reece JC, Dangerfield DC, and Coombs CJ. End ‐to‐side Somatic‐to‐autonomic Nerve Grafting to Restore Erectile Function and Improve Quality of Life After Radical Prostatectomy. Eur Urol 2019; 76(2):189‐196
AbstractA fascinating research on management of erectile dysfunction (ED) after radical prostatectomy (RP) was reported. They described the efficacy of end ‐to‐side somatic‐to‐autonomic nerve grafting on restoring erectile function (EF). Finally, this technique improved EF for 71% (12/17) ED patients after RP, while 29% were failed. Actually, Souza Trindade et al. has previous investigated this technique to improve EF after RP, however, 40% was failed [1]. Meanwhile, compared with the control rats, end‐to‐side neurorrhaphy also presented significantly lower EF after donor somatic nerve impairment [2]. (Source: Andrology)
Source: Andrology - December 30, 2019 Category: Urology & Nephrology Authors: Songlei Yan, Tao Li, Hua Shi Tags: LETTER TO THE EDITOR Source Type: research

Differential gene expression profiles of human efferent ducts and proximal epididymis
AbstractBackgroundGene expression patterns along the epididymis are established by specific transcription factor networks that coordinate region ‐specific functions. In rodents, the epididymis can be divided in up to 19 segments. Based on gross anatomy, the human epididymis is divided in caput, corpus and cauda segments together with efferent ducts that occupy the proximal part of this organ.ObjectivesTo determine to which extent gene expression pattern is segmented along the efferent ducts and the proximal region of the epididymis in men of reproductive age.Materials and methodsEpididymal transcriptome profiling was per...
Source: Andrology - December 27, 2019 Category: Urology & Nephrology Authors: Christine L égaré, Robert Sullivan Tags: ORIGINAL ARTICLE Source Type: research

Lycopene attenuates CP/CPPS by inhibiting oxidative stress and inflammation via the interaction of NF ‐κB, MAPKs and Nrf2 signaling pathways in rats
ConclusionsFindings in this study suggest that lycopene exerts potent anti ‐CP effects through alleviating inflammatory response and oxidative stress (OS), which is probably attributed to the interaction of NF‐κB, MAPKs and Nrf2 signaling pathways in rats. As a natural antioxidant, lycopene may serve as a promising pharmaceutical preparation for treating chronic prost atitis. (Source: Andrology)
Source: Andrology - December 26, 2019 Category: Urology & Nephrology Authors: Qinxin Zhao, Feiya Yang, Lingquan Meng, Dong Chen, Mingshuai Wang, Xinxing Lu, Dexi Chen, Yongguang Jiang, Nianzeng Xing Tags: ORIGINAL ARTICLE Source Type: research

Use of follicle ‐stimulating hormone (FSH) for the male partner of idiopathic infertile couples in Italy: Results from a multicentre, observational, clinical practice survey
AbstractBackgroundThe management of male idiopathic infertility is heterogeneous. Although meta ‐analyses reported the effectiveness on pregnancy rate, the real clinical impact of follicle‐stimulating hormone (FSH) was not evaluated so far. In Italy, FSH is approved by the national Medicines Agency (AIFA) for idiopathic infertile patients with FSH   18 years, FSH serum levels 
Source: Andrology - December 24, 2019 Category: Urology & Nephrology Authors: Daniele Santi, Sara De Vincentis, Patrizia Alfano, Giancarlo Balercia, Aldo E. Calogero, Francesco Cargnelutti, Maria Elisabetta Coccia, Rosita A. Condorelli, Alessandro Dal Lago, Cristina De Angelis, Mariagrazia Gallo, Nicola Iannantuoni, Fra Tags: ORIGINAL ARTICLE Source Type: research

Male Partners of Infertile Couples with Congenital Unilateral Absence of the Vas Deferens are mainly Non ‐Azoospermic
ConclusionsOur results indicate that men with CUAVD mainly display oligozoospermia or normozoospermia and that they were previously fertile. They clearly confirm, first, thatCFTR testing is recommended in CUAVD men and it should be mandatory for those with normal kidneys; and, second, that TRUS is needed for the diagnosis of CUAVD. As CUAVD may be present whatever the sperm count, biological warnings are represented by semen volume and seminal epididymal markers, and clinical warnings by surgical histories of undescended testes or inguinal hernia. (Source: Andrology)
Source: Andrology - December 24, 2019 Category: Urology & Nephrology Authors: R. Mieusset, E. Bieth, M. Daudin, F. Isus, B. Delaunay, L. Bujan, L. Monteil, I. Fauquet, E. Huyghe, S.M. Hamdi Tags: ORIGINAL ARTICLE Source Type: research

FSH Treatment of male idiopathic infertility: Time for a paradigm change
AbstractFollicle ‐stimulating hormone (FSH) has been used in inconclusive clinical trials for male idiopathic infertility in the past. FSH is sometimes prescribed empirically for male idiopathic infertility, showing some improvement in sperm parameters in about half of the patients. In this opinion article we brie fly analyze the pathophysiological evidences in favor of a more aggressive approach in planning future studies on pharmacological FSH use in male infertility, in analogy with the FSH use for multiple follicular growth in women undergoing ovarian stimulation for assisted reproduction. There is suffic ient eviden...
Source: Andrology - December 24, 2019 Category: Urology & Nephrology Authors: Manuela Simoni, Daniele Santi Tags: OPINION ARTICLE Source Type: research

Periovulatory oviductal fluid decreases sperm PKA activity, tyrosine phosphorylation and in vitro fertilization in pig
ConclusionOF from follicular, early luteal and periovulatory phases of the estrous cycle modulate the sperm protein phosphorylation as well as the AR involved in capacitation and increase monospermic fertilization in IVF. Our findings suggest that fluids from the female reproductive tract could be used as additives in porcine IVF systems to modulate sperm ‐oocyte interaction. (Source: Andrology)
Source: Andrology - December 23, 2019 Category: Urology & Nephrology Authors: H éctor Zapata‐Carmona, Cristina Soriano‐Úbeda, Evelyne París‐Oller, Carmen Matás Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
Andrology, Volume 8, Issue 1, Page 1-3, January 2020. (Source: Andrology)
Source: Andrology - December 22, 2019 Category: Urology & Nephrology Tags: Issue Information Source Type: research

Announcing the Sixth Andrology Award
Andrology, Volume 8, Issue 1, Page 5-6, January 2020. (Source: Andrology)
Source: Andrology - December 22, 2019 Category: Urology & Nephrology Authors: D. T. Carrell, M. Simoni Tags: EDITORIAL Source Type: research

Thanks Doug! Welcome Marie ‐Claude!
Andrology, Volume 8, Issue 1, Page 4-4, January 2020. (Source: Andrology)
Source: Andrology - December 22, 2019 Category: Urology & Nephrology Authors: Manuela Simoni Tags: EDITORIAL Source Type: research

European Academy of Andrology Budapest School
Andrology, Volume 8, Issue 1, Page 259-259, January 2020. (Source: Andrology)
Source: Andrology - December 22, 2019 Category: Urology & Nephrology Tags: Newsletter Source Type: research

Novel ADGRG2 truncating variants in patients with X ‐linked Congenital Absence of Vas Deferens
ConclusionOur results confirm the interest ofADGRG2 sequencing in patients with CAVD not formerly related to CFTR dysfunction, especially in absence of associated unilateral renal agenesis. (Source: Andrology)
Source: Andrology - December 17, 2019 Category: Urology & Nephrology Authors: Adrien Pagin, Anne Bergougnoux, Emmanuelle Girodon, Marie ‐Pierre Reboul, Christelle Willoquaux, Maryse Kesteloot, Caroline Raynal, Thierry Bienvenu, Mathilde Humbert, Guy Lalau, Eric Bieth Tags: ORIGINAL ARTICLE Source Type: research

Is androgen deprivation therapy for prostate cancer associated with cardiovascular disease? A meta ‐analysis and systematic review
AbstractBackgroundAndrogen deprivation therapy (ADT) is widely being applied in men who suffered from prostate cancer. Whether androgen deprivation therapy (ADT) is associated with an increased risk of developing cardiovascular ‐related disease is poorly defined.ObjectivesThe aim of the present meta ‐analysis is to explore the relationship between ADT and the risk of cardiac events.Materials and  methodsFor this systematic review and  meta‐analysis, we searched databases from inception to April 2019 for randomized controlled trials (RCT) or observational studies that reported data on ADT administration and ...
Source: Andrology - December 17, 2019 Category: Urology & Nephrology Authors: Zhen Liang, Jun Zhu, Longlong Chen, Yawei Xu, Yongjiao Yang, Rui Hu, Wei Zhang, Yuxuan Song, Yi Lu, Ningjing Ou, Xiaoqiang Liu Tags: REVIEW ARTICLE Source Type: research

Increased DNA methylation in the spermatogenesis associated (SPATA) genes correlates with infertility
AbstractIntroductionSpermatogenesis ‐associated (SPATA) family of genes plays important roles in spermatogenesis, sperm maturation or fertilization. The knockout studies in mice have demonstrated that SPATA genes are crucial for fertility. Gene expression and genetic polymorphism studies have further suggested their correlation with infertility; however, methylation analysis of SPATA genes in human male infertility has not yet been undertaken.MethodsIn the present study, we have analyzed DNA methylation pattern in the promoter regions ofSPATA4,SPATA5 andSPATA6 genes in oligozoospermic patients and compared it with normoz...
Source: Andrology - December 15, 2019 Category: Urology & Nephrology Authors: Sujit Kumar Mohanty, Vertika Singh, Sameer Trivedi, Kiran Singh, Gopal Gupta, Singh Rajender Tags: ORIGINAL ARTICLE Source Type: research

In ‐vitro spermatogenesis through testis modelling: towards the generation of testicular organoids
ConclusionFurther improvements in culture methodology and medium composition have to be made before being able to provide both testicular tubulogenesis and spermatogenesis in ‐vitro. (Source: Andrology)
Source: Andrology - December 11, 2019 Category: Urology & Nephrology Authors: Guillaume Richer, Yoni Baert, Ellen Goossens Tags: REVIEW ARTICLE Source Type: research

Predictive value of oxidative stress testing in semen for sperm DNA fragmentation assessed by sperm chromatin dispersion test
AbstractBackgroundAlthough a cornerstone of male infertility investigation, standard semen analysis has significant limitations. Seminal oxidative stress and DNA damage have shown potential to better predict male fertility potential and provide improved diagnostic and management strategies.ObjectiveThe aim of this study was to investigate if seminal oxidation ‐reduction potential (ORP), a new parameter to measure oxidative stress directly, can accurately predict the percentage of sperm DNA fragmentation (SDF) and thereby serve as a surrogate marker in the evaluation of male infertility.Materials and MethodsORP was evalua...
Source: Andrology - December 11, 2019 Category: Urology & Nephrology Authors: Haitham Elbardisi, Renata Finelli, Ashok Agarwal, Ahmad Majzoub, Ralf Henkel, Mohamed Arafa Tags: ORIGINAL ARTICLE Source Type: research

Risks of Genetic Damage in Offspring Conceived Using Sperm Produced during Chemotherapy or Radiotherapy
ConclusionsA schema showing the time from initiation of therapy at which specific antineoplastic agents can cause significant levels of genetic damage in conceptuses and live offspring was developed. The estimates and methods for computing the level of such risk from an individual patient's treatment regimen will enable patients and counselors to make informed decisions on the use of sperm or continuation of a pregnancy. (Source: Andrology)
Source: Andrology - December 10, 2019 Category: Urology & Nephrology Authors: Marvin L. Meistrich Tags: REVIEW ARTICLE Source Type: research

Cholesterol accumulation, lipid droplet formation, and steroid production in Leydig cells: Role of translocator protein (18 ‐kDa)
ConclusionThese results support the conclusion that FGIN ‐1‐27 stimulates steroid formation by increasing TSPO‐mediated cholesterol translocation into the inner mitochondria for steroidogenesis, as well as into the cytosol for lipid droplet formation. FGIN‐1‐27 also increased steroid formation at least in part by inducing the conversion of chole steryl ester located in lipid droplets to cholesterol, thus making available more substrate for steroid formation. (Source: Andrology)
Source: Andrology - December 9, 2019 Category: Urology & Nephrology Authors: Jin ‐Yong Chung, Haolin Chen, Vassilios Papadopoulos, Barry Zirkin Tags: ORIGINAL ARTICLE Source Type: research

Malaysian propolis and metformin mitigate subfertility in streptozotocin ‐induced diabetic male rats by targeting steroidogenesis, testicular lactate transport, spermatogenesis and mating behaviour
ConclusionMP improves fertility potential in diabetic state by targeting steroidogenesis, testicular lactate metabolism, spermatogenesis and mating behaviour, with better effects when co ‐administered with Met. Therefore, MP shows a promising complementary effect with Met in mitigating DM‐induced subfertility/infertility. (Source: Andrology)
Source: Andrology - December 9, 2019 Category: Urology & Nephrology Authors: Victor Udo Nna, Ainul Bahiyah Abu Bakar, Azlina Ahmad, Usman Zayyanu Umar, Joseph Bagi Suleiman, Zaida Zakaria, Zaidatul Akmal Othman, Mahaneem Mohamed Tags: ORIGINAL ARTICLE Source Type: research

Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples
ConclusionThe results of this study demonstrate that STL is associated with in vitro fertilization rates, but not with semen parameters nor lifestyle factors. Further investigations are warranted to identify the potential variation of STL overtime to clarify its significance as a potential biomarker in ART. (Source: Andrology)
Source: Andrology - November 26, 2019 Category: Urology & Nephrology Authors: S.C. Berneau, J. Shackleton, C. Nevin, B. Altakroni, G. Papadopoulos, G. Horne, D.R. Brison, C. Murgatroyd, A.C. Povey, M. Carroll Tags: ORIGINAL ARTICLE Source Type: research

Increasing paternal age and ejaculatory abstinence length negatively influence the intracytoplasmic sperm injection outcomes from egg ‐sharing donation cycles
ConclusionAdditional tracking of the influence of male characteristics on ICSI outcomes should be stimulated. Paternal age is not manageable, but reducing EA could be an alternative approach to improve the outcomes of ICSI. (Source: Andrology)
Source: Andrology - November 22, 2019 Category: Urology & Nephrology Authors: Amanda S. Setti, Daniela Paes Almeida Ferreira Braga, Assumpto Iaconelli, Edson Borges Tags: ORIGINAL ARTICLE Source Type: research

Ferulago angulata Extract Ameliorates Epididymal Sperm Toxicity in Mice Induced by Lead and Diazinon
ConclusionTheFerulago angulata extract should be considered as a useful natural extract for the treatment of male infertility, especially in males exposed to conditions which induce reproductive toxicity. (Source: Andrology)
Source: Andrology - November 20, 2019 Category: Urology & Nephrology Authors: Nushin Naderi, Manochehr Souri, Mohammad Hossein Nasr Esfahani, Mehdi Hajian, Nima Tanhaei Vash Tags: ORIGINAL ARTICLE Source Type: research

Is Androgen Deprivation Therapy for Prostate Cancer Associated with Cardiovascular disease ? A Meta ‐Analysis and systematic review
AbstractBackgroundWhether androgen deprivation therapy (ADT) is associated with an increased risk of developing cardiovascular related disease is poorly defined. The aim of the present meta ‐analysis is to explore the relationship between ADT and the risk of cardiac events.MethodFor this systematic review and  meta‐analysis, we searched databases from inception to April 2019 for randomized controlled trials (RCT) or observational studies that reported data on ADT administration and cardiac events incidence. The connection was evaluated through estimating relative risk ratio (RR) and 95% confidence int ervals (CIs)...
Source: Andrology - November 19, 2019 Category: Urology & Nephrology Authors: Zhen Liang, Jun Zhu, Longlong Chen, Yawei Xu, Yongjiao Yang, Rui Hu, Wei Zhang, Yuxuan Song, Yi Lu, Ningjing Ou, Xiaoqiang Liu Tags: REVIEW ARTICLE Source Type: research

Cholesterol Accumulation, Lipid Droplet Formation and Steroid Production in Leydig Cells: Role of Translocator Protein (18 ‐kDa)
ConclusionThese results support the conclusion that FGIN ‐1‐27 stimulates steroid formation by increasing TSPO‐mediated cholesterol translocation into the inner mitochondria for steroidogenesis, as well as into the cytosol for lipid droplet formation. FGIN‐1‐27 also increased steroid formation at least in part by inducing the conversion of chole steryl ester located in lipid droplets to cholesterol, thus making available more substrate for steroid formation. (Source: Andrology)
Source: Andrology - November 18, 2019 Category: Urology & Nephrology Authors: Jin ‐Yong Chung, Haolin Chen, Vassilios Papadopoulos, Barry Zirkin Tags: ORIGINAL ARTICLE Source Type: research

Myo ‐inositol in health and disease: its impact on semen parameters and male fertility
ConclusionMI was reported as an effective supplement for sperm quality. In any case, several study designs lack appropriate controls or data analysis to confirm the relevance of the findings. While promising, larger prospective randomized controlled studies will be required to confirm the positive effect of MI supplementation in male infertility management. Moreover, further investigations are encouraged to unravel MI roles in sperm physiology and the underlying molecular mechanisms. (Source: Andrology)
Source: Andrology - November 17, 2019 Category: Urology & Nephrology Authors: M.H. Vazquez-Levin, G.L. Ver ón Tags: Review Article Source Type: research

Late ‐onset hypogonadism: a concept comes of age
AbstractThe termLate ‐onset hypogonadism (LOH) was coined in 2002 and defined as a disease entity in the ISA, ISSAM, EAU, EAA and ASA endorsed Recommendations for Investigation, Treatment and Monitoring of LOH (2005 and 2008) as ‘a clinicaland biochemical syndrome associated with advancing age, characterized by symptomsand a deficiency in serum testosterone (T) ’. LOH was classified as a combined primary and secondary hypogonadism since the endocrine capacity of the testes and the pituitary are impaired. Symptoms of LOH include loss of libido, erectile dysfunction, loss of muscle mass, increased body fat, ane...
Source: Andrology - November 15, 2019 Category: Urology & Nephrology Authors: E. Nieschlag Tags: Review Article Source Type: research

Cyclooxygenase 2 (COX2) Expression and prostaglandin synthesis in Neonatal Rat Testicular Germ Cells: Effects of Acetaminophen and Ibuprofen
ConclusionUnderstanding COX2 role in neonatal gonocytes and the potential risk of acetaminophen and ibuprofen treatment of infants may help prevent male reproductive pathologies. (Source: Andrology)
Source: Andrology - November 9, 2019 Category: Urology & Nephrology Authors: Gurpreet Manku, Philippos Papadopoulos, Annie Boisvert, Martine Culty Tags: ORIGINAL ARTICLE Source Type: research

Roadmap of Germline Development and In Vitro Gametogenesis from Pluripotent Stem Cells
ConclusionIn vitro gametogenesis will constitute an emergent new field in human reproductive medicine in the near future, although legal and ethical considerations must be taken into account. (Source: Andrology)
Source: Andrology - November 9, 2019 Category: Urology & Nephrology Authors: Karen Makar, Kotaro Sasaki Tags: REVIEW ARTICLE Source Type: research

Historical Vignette: Attempted treatment of Sigmund Freud's oral squamous cell carcinoma by vasectomy (Steinach Operation) in 1923
AbstractAt the beginning of the 20th century, the Viennese physiologist Eugen Steinach proposed to treat the effects of physiological ageing by vasectomy. He had deduced that the ligation of thevas deferens allowed to increase the level of hormones secreted by the gonads: indeed, thevas deferens being the channel through which the spermatozoa are evacuated, if it is ligated, the spermatozoa can not go out and therefore their accumulation induces a hyper ‐pressure inside the gland which induces a proliferation and a modification of the epithelium, and thus a greater secretion of hormones (1). (Source: Andrology)
Source: Andrology - November 8, 2019 Category: Urology & Nephrology Authors: Nadia Benmoussa, Philippe Charlier, John ‐David Rebibo Tags: SHORT COMMUNICATION Source Type: research

Low serum testosterone levels and the incidence of chronic kidney disease among male adults: A prospective population based study
This study aimed to investigate the incidence and hazard ratio of CKD among male adults with low testosterone levels compared to controls with normal testosterone levels.Materials and MethodsDuring a 15 ‐year follow‐up study, a total of 1277 eligible male adults aged 20‐80 years consisting of 605 males with low testosterone levels (
Source: Andrology - November 7, 2019 Category: Urology & Nephrology Authors: Mina Amiri, Fahimeh Ramezani Tehrani, Maryam Rahmati, Saber Amanollahi Soudmand, Samira Behboudi ‐Gandevani, Zari Sabet, Fereidoun Azizi Tags: ORIGINAL ARTICLE Source Type: research