Issue Information
(Source: Andrology)
Source: Andrology - January 14, 2022 Category: Urology & Nephrology Tags: ISSUE INFORMATION Source Type: research

The association of free testosterone levels with coronavirus disease 2019
ConclusionA high rate of hypogonadism (71.6%) was found, especially secondary hypogonadism, and about half of the patients had hypogonadism in the sixth months' follow-up. Low free testosterone levels were correlated with inflammatory parameters, and it is related to the intensive care unit admission. Studies with long-term follow-up data in larger groups are needed to determine persistent hypogonadism and impaired spermatogenesis. (Source: Andrology)
Source: Andrology - January 14, 2022 Category: Urology & Nephrology Authors: Tugce Apaydin, Bahad ır Sahin, Saida Dashdamirova, Ceyda Dincer Yazan, Onur Elbasan, Can Ilgin, Hüseyin Bilgin, Haydar Kamil Cam, Gunel Bahramzada, Aleyna Kucuk, Goncagul Haklar, Hulya Iliksu Gozu Tags: ORIGINAL ARTICLE Source Type: research

Restoring erectile function by combined treatment with JNK inhibitor and HDAC inhibitor in a rat model of cavernous nerve injury
ConclusionsThe combined administration of JNKi and HDACi during the acute phase after CNCI in rats can preserve erectile dysfunction by suppressing cavernosal fibrosis and apoptosis by normalizing the HDAC/TGF- β and JNK pathways.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - January 13, 2022 Category: Urology & Nephrology Authors: Junghoon Lee, Min Chul Cho, Hwancheol Son, Soo Woong Kim Tags: ORIGINAL ARTICLE Source Type: research

Clomiphene citrate for men with hypogonadism: a systematic review and meta ‐analysis
ConclusionClomiphene citrate is an effective therapy for improving both biochemical as well as clinical symptoms of males suffering from hypogonadism. Clomiphene citrate has few reported side effects and good safety aspects. (Source: Andrology)
Source: Andrology - January 10, 2022 Category: Urology & Nephrology Authors: Manou Huijben, M. Tycho W.T. Lock, Vincent F. Kemp, Laetitia M.O. Kort, H.M.K Breda Tags: REVIEW ARTICLE Source Type: research

A new oral testosterone (TLANDO ®) treatment regimen without dose titration requirement for male hypogonadism
AbstractBackgroundMale hypogonadism (Testosterone level
Source: Andrology - January 8, 2022 Category: Urology & Nephrology Authors: Anthony DelConte, Kongnara Papangkorn, Kilyoung Kim, Benjamin J. Bruno, Nachiappan Chidambaram, Mohit Khera, Irwin Goldstein, Tobias S. Kohler, Martin Miner, Adrian S. Dobs, Mahesh V. Patel Tags: ORIGINAL ARTICLE Source Type: research

The association of free testosterone levels with COVID ‐19
ConclusionA high rate of hypogonadism (71.6%) was found, especially secondary hypogonadism, and about half of the patients had hypogonadism in the 6th-months follow-up. Low free testosterone levels were correlated with inflammatory parameters, and it is related to ICU admission. Studies with long-term follow-up data in larger groups are needed to determine persistent hypogonadism and impaired spermatogenesis.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - January 7, 2022 Category: Urology & Nephrology Authors: Tugce Apaydin, Bahad ır Sahin, Saida Dashdamirova, Ceyda Dincer Yazan, Onur Elbasan, Can Ilgin, Hüseyin Bilgin, Haydar Kamil Cam, Gunel Bahramzada, Aleyna Kucuk, Goncagul Haklar, Hulya Iliksu Gozu Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: Andrology)
Source: Andrology - December 30, 2021 Category: Urology & Nephrology Tags: ISSUE INFORMATION Source Type: research

With our sincere thanks: Farewell to Manuela Simoni and welcome to Aleksander Giwercman
(Source: Andrology)
Source: Andrology - December 30, 2021 Category: Urology & Nephrology Authors: Marie ‐Claude Hofmann, Aleksander Giwercman Tags: EDITORIAL Source Type: research

Association of urinary organophosphate esters level with sex steroid hormones levels in adult males: A nationwide study, NHANES 2013 –2014
ConclusionAccording to our study, which is based on a representative population of US adults, exposure to OPEs was significantly associated with altered sex hormone levels (total testosterone and estradiol). Further studies focused on the underlying mechanisms regarding the association between each metabolite and sex steroid hormones are required.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - December 29, 2021 Category: Urology & Nephrology Authors: Zeyu Chen, Shi Qiu, Chichen Zhang, Yu Zhan, Liangren Liu, Yige Bao, Bo Chen, Yunjin Bai, Xiaonan Zheng, Yin Huang, Kun Jin, Ping Han, Qiang Wei Tags: ORIGINAL ARTICLE Source Type: research

An evaluation of changes over time in the semen parameters data used for the World Health Organization semen analysis reference ranges
AbstractBackgroundPrevious meta-analyses concluded that there is a decline in sperm parameters over time. This conclusion might be incorrect due to inherent biases or focusing only on a single parameter – sperm concentration.ObjectiveTo study trends in sperm parameters over the past twenty years using data from the trials that defined the reference ranges of the World Health Organization manual.Materials and methodsRetrospective evaluation of the data used to define the World Health Organization reference ranges. The data from 11 studies, including 3589 participants between 1996 –2016, were divided into three p...
Source: Andrology - December 29, 2021 Category: Urology & Nephrology Authors: Ido Feferkorn, Liat Azani, Einav Kadour ‐Peero, Ranit Hizkiyahu, Guy Shrem, Mali Salmon‐Divon, Michael H. Dahan Tags: ORIGINAL ARTICLE Source Type: research

Penile fracture: Tertiary care center experience and long ‐term complications after immediate repair
ConclusionWe found that the longer time interval between penile fracture and surgery worsened the patient outcomes. In addition, tear size was determined to be a predictor for long-term complications. In our opinion, early treatment of penile fracture can prevent severe complications in these cases.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - December 23, 2021 Category: Urology & Nephrology Authors: Emre Bulbul, Mehmet Hamza Gultekin, Sinharib Citgez, Engin Derekoylu, Muhammet Demirbilek, Emre Akkus, Hamdi Ozkara Tags: ORIGINAL ARTICLE Source Type: research

Muscle function following testosterone replacement in men on opioid therapy for chronic non ‐cancer pain ‐ a randomized controlled trial
AbstractBackground: Chronic pain and opioid treatment are associated with increased risk of male hypogonadism and subsequently decreased muscle function. A diagnosis of hypogonadism is based on the presence of low total testosterone (TT) and associated symptoms. The effect of testosterone replacement therapy (TRT) on muscle function in men with chronic pain and low TT remains to be investigated.Objectives: To investigate effects of TRT on muscle function and gait performance in men treated with opioids for chronic non-cancer pain.Materials and methods: Double-blind, placebo-controlled study. 41 men (>18 years) with opio...
Source: Andrology - December 22, 2021 Category: Urology & Nephrology Authors: Mikkel Iwanoff Kolind, Louise Lehmann Christensen, Paolo Caserotti, Marianne Skovsager Andersen, Dorte Glintborg Tags: ORIGINAL ARTICLE Source Type: research

5 ‐Alpha reductase inhibitor related litigation: A legal database review
Conclusion: 5ARi were alleged to have sexual, mental, and physical side effects, resulting in legal litigation. Despite this, no judgement against a physician nor pharmaceutical company was identified. We do note and discuss a large number of lawsuits settled out of court. Given the increase in the number of lawsuits resulting in verdicts over the last 3 years we suspect that the frequency of litigation around 5ARi will continue for the foreseeable future.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - December 21, 2021 Category: Urology & Nephrology Authors: Patrick Low, Kevin D. Li, Nizar Hakam, Alexander Bell, Behzad Abbasi, Jason Lui, Nathan M. Shaw, Benjamin N. Breyer Tags: ORIGINAL ARTICLE Source Type: research

Clomiphene Citrate for Men with Hypogonadism ‐ A Systematic Review & Meta ‐analysis
Conclusion: CC is an effective therapy for improving both biochemical as well as clinical symptoms of males suffering from hypogonadism. CC has few reported side-effects and good safety aspects.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - December 21, 2021 Category: Urology & Nephrology Authors: M. Huijben, M.T.W.T Lock, V.F. Kemp, L.M.O. Kort, H.M.K Breda Tags: REVIEW ARTICLE Source Type: research

Exploring the role of gut microbiome in male reproduction
This study discusses therapeutic options such as probiotics, prebiotics, and fecal microbiota transplantation, as well as the challenges and opportunities behind ongoing research, and emphasizes the need for additional research in the future to demonstrate the links and underlying mechanisms between gut microbiome and male reproduction. Therapeutic options such as probiotic, prebiotics and fecal microbiota transplantation are potential treatments for male infertility.Discussion and conclusionGut microbiota may have a causal role in male reproduction health, therapeutic strategies such as supplementation with appropriate pr...
Source: Andrology - December 17, 2021 Category: Urology & Nephrology Authors: Yan Wang, Zuogang Xie Tags: REVIEW ARTICLE Source Type: research

The impact of androgen deprivation therapy on bone mineral density in men treated for paraphilic disorder: A retrospective cohort study
AbstractBackgroundGuidelines suggest treating men with paraphilic disorder with androgen-deprivation therapy (ADT). However little evidence is available about the long-term impact on bone loss and how to manage this adverse event.ObjectivesThe aim of this study is to assess the impact of ADT on bone mineral density (BMD) in men treated for paraphilic disorder with the androgen receptor blocker cyproterone acetate (CPA) and/or GnRH agonist triptoreline (GnRHa), and to evaluate the effect of treatment with bisphosphonates.MethodsBaseline and follow-up dual-energy X-ray absorptiometry scan (DXA-scan) data (lumbar and femoral ...
Source: Andrology - December 16, 2021 Category: Urology & Nephrology Authors: Ana ïs De Landtsheer, Lieslinde Bekaert, Karel David, Philippe Marcq, Inge Jeandarme, Brigitte Decallonne, Leen Antonio, Dirk Vanderschueren Tags: ORIGINAL ARTICLE Source Type: research

Machine learning based prediction models in male reproductive health: development of a proof ‐of‐concept model for Klinefelter Syndrome in azoospermic patients
ConclusionsMachine learning could improve the diagnostic rate of KS among azoospermic patients, even more for less experienced physicians.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - December 16, 2021 Category: Urology & Nephrology Authors: H. Krenz, A. Sansone, M. Fujarski, C. Krallmann, M. Zitzmann, M. Dugas, S. Kliesch, J. Varghese, F. T üttelmann, J. Gromoll Tags: ORIGINAL ARTICLE Source Type: research

In Memoriam: Stuart B. Moss, PhD, April 1, 1950 –November 13, 2021
(Source: Andrology)
Source: Andrology - December 15, 2021 Category: Urology & Nephrology Authors: George L. Gerton, Pablo E. Visconti Tags: SHORT COMMUNICATION Source Type: research

Ram epididymal sperm frozen in an extender containing ethylene glycol have higher post ‐thaw longevity and in vitro fertility
AbstractBackground: Establishing an efficient, simple and inexpensive method for freezing ram epididymal sperm so that the quality and fertility of sperm could be maintained for a longer period after thawing is of great practical value.Objectives: To optimize freezing and thawing protocol for ram epididymal sperm using either ethylene glycol (EG) or glycerol (GLY) as cryoprotectants (CPAs). Then, to evaluate the post-thaw longevity and in vitro fertility of sperm that were frozen and thawed according to the optimized protocol.Materials and methods: At first, an optimum protocol for freezing and thawing sperm using EG or GL...
Source: Andrology - December 14, 2021 Category: Urology & Nephrology Authors: Ebrahim Ahmadi, Naser shams ‐Esfandabadi, Hassan Nazari, Najmeh Davoodian, Ali Kadivar Tags: ORIGINAL ARTICLE Source Type: research

The impact of Diabetes Mellitus type 1 on male fertility: Systematic review and meta ‐analysis
AbstractBackgroundSome evidence suggests that Diabetes Mellitus type 1 (DM1) could affect male fertility, gonadal axis, semen parameters, and spermatogenesis due to effects of hyperglycemia and insulin deficiency. Anyhow, the exact impact of DM1 on male fertility is unclear.ObjectivesTo review the studies evaluating paternity rate, male gonadal axis, and semen parameters in men with DM1.Materials and MethodsA review of relevant literature from January 1980 to December 2020 was performed. Only studies published in English reporting data on fatherhood (rate of children by natural fertility), hormonal and seminal parameters w...
Source: Andrology - December 14, 2021 Category: Urology & Nephrology Authors: Paolo Facondo, Elena Di Lodovico, Andrea Delbarba, Valentina Anelli, Letizia Chiara Pezzaioli, Erica Filippini, Carlo Cappelli, Giovanni Corona, Alberto Ferlin Tags: REVIEW ARTICLE Source Type: research

Male reproductive system inflammation after healing from coronavirus disease 2019
Discussion and conclusionNegative correlations between interleukin-1 β and tumor necrosis factor-α and sperm number and the overall high levels of semen cytokines indicate a potential detrimental role of severe acute respiratory syndrome coronavirus 2 driven inflammation on spermatogenesis. Overall, our results indicate that male patients recovering from coronaviru s disease 2019 deserve accurate follow-up for their fertility status. (Source: Andrology)
Source: Andrology - December 14, 2021 Category: Urology & Nephrology Authors: Simone Morselli, Arcangelo Sebastianelli, Andrea Liaci, Claudia Zaccaro, Alessio Pecoraro, Rossella Nicoletti, Alekseja Manera, Claudio Bisegna, Riccardo Campi, Simona Pollini, Alberto Antonelli, Filippo Lagi, Marco Coppi, Elisabetta Baldi, Tags: ORIGINAL ARTICLE Source Type: research

Male Reproductive System Inflammation After Healing From COVID ‐19
This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - December 9, 2021 Category: Urology & Nephrology Authors: Simone Morselli, Arcangelo Sebastianelli, Andrea Liaci, Claudia Zaccaro, Alessio Pecoraro, Rossella Nicoletti, Alekseja Manera, Claudio Bisegna, Riccardo Campi, Simona Pollini, Alberto Antonelli, Filippo Lagi, Marco Coppi, Elisabetta Baldi, Tags: ORIGINAL ARTICLE Source Type: research

The upregulation of tryptophan hydroxylase ‐2 expression is important for premature ejaculation treatment with the selective serotonin reuptake inhibitor
This study aimed to investigate whether changes in brain TPH2 levels were associated with PE and to explore the effects of acute administration of dapoxetine on TPH2 expression in the brain of rats with rapid ejaculation.Materials and methodsBased on the ejaculation frequency, the male rats were split into three groups, “rapid”, “normal”, “sluggish” ejaculators. The level of 5-HT in the brain was determined by enzyme-linked immunosorbent assay. TPH2 expression was detected by Western Blot analysis and immunohistochemistry.ResultsThe results showed that the concentration of 5-HT and the e...
Source: Andrology - December 7, 2021 Category: Urology & Nephrology Authors: Tianle Zhu, Pan Gao, Jingjing Gao, Xi Liu, Hui Jiang, Xiansheng Zhang Tags: ORIGINAL ARTICLE Source Type: research

Male genome influences embryonic development as early as pronuclear stage
AbstractBackgroundImpaired paternal genome expression may cause poor embryonic development after in vitro fertilization (IVF).ObjectiveTo evaluate the expression of male infertility on embryo morphokinetics using a time-lapse incubator and its impact on IVF cycles.Materials and methodsThis retrospective cohort study followed patients from January 2017 to August 2019. Patients were divided according to the cause of infertility to male factor (study group) and unexplained infertility (control group) and further subdivided according to the severity of male infertility.ResultsA cohort of 462 patients who underwent IVF cycles, ...
Source: Andrology - November 29, 2021 Category: Urology & Nephrology Authors: Aviv Peer, Yuval Atzmon, Nardin Aslih, Asaf Bilgory, Daniela Estrada, Yasmin Shibli Abu Raya, Einat Shalom ‐Paz Tags: ORIGINAL ARTICLE Source Type: research

Type 2 diabetes mellitus increases risk of erectile dysfunction independent of obesity and dyslipidemia: A Mendelian randomization study
AbstractBackgroundThe causal effects of individual risk factors of metabolic syndrome on erectile dysfunction (ED) are still unclearObjectivesTo evaluate the causal effect of risk factors of metabolic syndrome on ED through Mendelian randomization (MR).Materials and methodsData for risk factors were obtained from multiple databases with 173,082 to 757,601 individuals, and that for ED were collected from a genome-wide association study including 223,805 Europeans. We performed univariate MR analysis using inverse-variance weighted, MR-Egger, weighted-median, weighted mode methods and multivariable MR analysis to evaluate th...
Source: Andrology - November 29, 2021 Category: Urology & Nephrology Authors: Chi Yuan, Zhongyu Jian, Xiaoshuai Gao, Xi Jin, Menghua Wang, Liyuan Xiang, Hong Li, Kunjie Wang Tags: ORIGINAL ARTICLE Source Type: research

Use of paracetamol (acetaminophen) as a nonprescription analgesic and semen quality in young men: A cross ‐sectional study
AbstractBackgroundParacetamol (acetaminophen) is a frequently used nonprescription analgesic with suggested endocrine-disrupting properties. Epidemiological evidence on the effect of paracetamol on male fecundity is sparse.ObjectivesTo investigate if the use of paracetamol as an oral nonprescription mild analgesic was associated with semen quality in young men.Materials and methodsThis cross-sectional study was based on data from the Fetal Programming of Semen Quality (FEPOS; 2017 –2019) cohort of 1058 young men (18–21 years) included in the Danish National Birth Cohort. Participants completed a comprehensive o...
Source: Andrology - November 26, 2021 Category: Urology & Nephrology Authors: Cecilie Schmidt Østergaard, Andreas Ernst, Anne Gaml‐Sørensen, Nis Brix, Gunnar Toft, Katia Keglberg Hærvig, Karin Sørig Hougaard, Jens Peter Bonde, Sandra Søgaard Tøttenborg, Cecilia Høst Ramlau‐Hansen Tags: ORIGINAL ARTICLE Source Type: research

The masturbatory premature ejaculation diagnostic tool (MPEDT): A novel psychometric tool to evaluate premature ejaculation during masturbation
ConclusionMPEDT could be considered a new, objective and reliable diagnostic tool for the evaluation of the existence of PE symptoms.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - November 26, 2021 Category: Urology & Nephrology Authors: Yu Xi, Hui Zhang, Elena Colonnello, Erika2 Limoncin, Emmanuele A. Jannini, Yan Zhang Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: Andrology)
Source: Andrology - November 24, 2021 Category: Urology & Nephrology Tags: ISSUE INFORMATION Source Type: research

The growing and interdisciplinary field of transgender health
(Source: Andrology)
Source: Andrology - November 24, 2021 Category: Urology & Nephrology Authors: Michael S. Irwig Tags: EDITORIAL Source Type: research

From subjective to objective: A pilot study on testicular radiomics analysis as a measure of gonadal function
ConclusionsRadiomics texture features qualitatively describe the testicular parenchyma with objective and reliable quantitative parameters, reflecting both the testicular spermatogenic capability and the action of pituitary gonadotropins. This is an innovative model in which US texture features represent a mirror of the pituitary-gonadal homeostasis in terms of reproductive function.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - November 24, 2021 Category: Urology & Nephrology Authors: Bruno De Santi, Giorgia Spaggiari, Antonio RM Granata, Marilina Romeo, Filippo Molinari, Manuela Simoni, Daniele Santi Tags: ORIGINAL ARTICLE Source Type: research

Long ‐term testosterone undecanoate treatment in the elderly testosterone deficient male: An observational cohort study
Discussion and conclusionAn increased number of adjustments of TU dose are necessary in elderly patients in order to reach treatment targets. TU treatment in elderly testosterone-deficient patients is not associated with an increased risk of polycythemia compared to younger patients if age-adjusted treatment targets are reached. (Source: Andrology)
Source: Andrology - November 24, 2021 Category: Urology & Nephrology Authors: Julie Abildgaard, J ørgen Holm Petersen, Anne Kirstine Bang, Lise Aksglaede, Peter Christiansen, Anders Juul, Niels Jørgensen Tags: ORIGINAL ARTICLE Source Type: research

Combination of trehalose and low boron in presence of decreased glycerol improves post ‐thawed ram sperm parameters: A model study in boron research
AbstractBackgroundSperm cryopreservation has been widely used in the field of reproductive biotechnology. It applies to certain males of economic and scientific values, including livestock breeds or endangered animal species. The development of a semen extender with a low cryoprotectant concentration and an appropriate amount of trehalose and boron can prevent the deterioration of sperm parameters.ObjectiveThe main goal of this study is to establish a suitable ram extender model, by examining different combinations of high (5%) and low (3%) glycerol concentrations (to reduce its toxic effects on sperm freezing), a fixed am...
Source: Andrology - November 16, 2021 Category: Urology & Nephrology Authors: Mustafa Numan Bucak, Nazan Keskin, Mustafa Bodu, B ülent Bülbül, Mesut Kırbaş, Ali Erdem Öztürk, Fatime Frotan, Pinar Ili, Hüseyin Özkan, Nuri Başpınar, Sükrü Dursun Tags: ORIGINAL ARTICLE Source Type: research

Use of paracetamol (acetaminophen) as a non ‐prescription analgesic and semen quality in young men ‐ a cross‐sectional study
AbstractBackgroundParacetamol (acetaminophen) is a frequently used non-prescription analgesic with suggested endocrine disrupting properties. Epidemiological evidence on the effect of paracetamol on male fecundity is sparse.ObjectivesTo investigate if use of paracetamol as an oral non-prescription mild analgesic was associated with semen quality in young men.Materials and methodsThis cross-sectional study was based on data from the Fetal Programming of Semen Quality (FEPOS; 2017 –2019) cohort of 1,058 young men (18-21 years) included in the Danish National Birth Cohort. Participants completed a comprehensive online q...
Source: Andrology - November 15, 2021 Category: Urology & Nephrology Authors: Cecilie Schmidt Østergaard, Andreas Ernst, Anne Gaml‐Sørensen, Nis Brix, Gunnar Toft, Katia Keglberg Hærvig, Karin Sørig Hougaard, Jens Peter Bonde, Sandra Søgaard Tøttenborg, Cecilia Høst Ramlau‐Hansen Tags: ORIGINAL ARTICLE Source Type: research

A higher preconceptional paternal body mass index influences fertilization rate and preimplantation embryo development
AbstractBackground: Obesity is a worldwide problem affecting the health of millions of people throughout the life course. Studies reveal that obesity impairs sperm parameters and epigenetics, potentially influencing embryonic development.Objective: To investigate the association between preconceptional paternal body mass index (BMI) and embryo morphokinetics using a time-lapse incubator and in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) outcomes.Materials and methods: Participants were recruited from a tertiary hospital in this prospective  periconceptional cohort study. A total of 211 m...
Source: Andrology - November 15, 2021 Category: Urology & Nephrology Authors: Jeffrey Hoek, Sam Schoenmakers, Linette Duijn, Sten. P. Willemsen, Eva S. Marion, Joop S.E. Laven, Esther B. Baart, R égine P.M. Steegers‐Theunissen Tags: ORIGINAL ARTICLE Source Type: research

Effect of the icariin on endothelial microparticles, endothelial progenitor cells, platelets, and erectile function in spontaneously hypertensive rats
AbstractObjectivesTo investigate the effect of icariin on endothelial microparticles (EMP), endothelial progenitor cells (EPC), platelets, and erectile function in spontaneously hypertensive rats (SHR).Materials and MethodsTwelve 8-week-old healthy male Wistar-Kyoto(WKY) rats and 12 SHR were randomly divided into four following groups: WKY control group (normal saline 1ml/d given by gavage), WKY+icariin group (icariin 10mg/kg •d dissolved in 1ml normal saline and given by gavage), SHR control group (normal saline 1ml/d given by gavage), and SHR+icariin group (icariin 10mg/kg•d dissolved in 1ml normal saline and g...
Source: Andrology - November 15, 2021 Category: Urology & Nephrology Authors: Xu Li, Hai ‐Fan Yang, Yong Chen, Li‐Jun Pei, Rui Jiang Tags: ORIGINAL ARTICLE Source Type: research

Are sperm parameters able to predict the success of assisted reproductive technology? A retrospective analysis of over 22,000 assisted reproductive technology cycles
AbstractBackgroundAn explosive increase in couples attending assisted reproductive technology has been recently observed, despite an overall success rate of about 20% –30%. Considering the assisted reproductive technology-related economic and psycho-social costs, the improvement of these percentages is extremely relevant. However, in the identification of predictive markers of assisted reproductive technology success, male parameters are largely underestimated so far.Study designRetrospective, observational study.ObjectivesTo evaluate whether conventional semen parameters could predict assisted reproductive technolog...
Source: Andrology - November 12, 2021 Category: Urology & Nephrology Authors: Maria Teresa Villani, Daria Morini, Giorgia Spaggiari, Angela Immacolata Falbo, Beatrice Melli, Giovanni Battista La Sala, Marilina Romeo, Manuela Simoni, Lorenzo Aguzzoli, Daniele Santi Tags: ORIGINAL ARTICLE Source Type: research

Surgical treatments for obstructive sleep apnea decrease the risk of erectile dysfunction: a nationwide cohort study
ConclusionsWe found that OSA patients who received surgical treatments were associated with lower risk for developing ED by 21%.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - November 8, 2021 Category: Urology & Nephrology Authors: Juen ‐Haur Hwang, Hueih‐Ling Ong, Yi‐Chun Chen Tags: ORIGINAL ARTICLE Source Type: research

Long ‐term testosterone undecanoate treatment in the elderly testosterone deficient male – an observational cohort study
ConclusionAn increased number of adjustments of TU dose are necessary in the elderly patients in order to reach treatment targets. TU treatment in elderly testosterone deficient patients is not associated with an increased risk of polycythemia compared to younger patients if age-adjusted treatment targets are reached.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - November 7, 2021 Category: Urology & Nephrology Authors: Julie Abildgaard, J ørgen Holm Petersen, Anne Kirstine Bang, Lise Aksglaede, Peter Christiansen, Anders Juul, Niels Jørgensen Tags: ORIGINAL ARTICLE Source Type: research

Are sperm parameters able to predict the success of assisted reproductive technologies? A retrospective analysis of over 22000 ART cycles
AbstractBackgroundAn explosive increase in couples attending assisted reproductive technologies (ART) has been recently observed, despite an overall success rate about 20 –30%. Considering the ART-related economic and psycho-social costs, the improvement of these percentages is extremely relevant. However, in the identification of predictive markers of ART success, male parameters are largely underestimated so far.Study designRetrospective, observational study.ObjectivesTo evaluate whether conventional semen parameters could predict the ART successMaterials and methodsAll couples attending a single third-level Fertil...
Source: Andrology - November 1, 2021 Category: Urology & Nephrology Authors: M. T. Villani, D. Morini, G. Spaggiari, A. I. Falbo, B. Melli, G. B. La Sala, M. Romeo, M. Simoni, L. Aguzzoli, D. Santi Tags: ORIGINAL ARTICLE Source Type: research

How routine pharmacovigilance failed to identify finasteride's persistent sexual side effects
(Source: Andrology)
Source: Andrology - October 29, 2021 Category: Urology & Nephrology Authors: Michael S Irwig Tags: OPINION ARTICLE Source Type: research

Issue Information
(Source: Andrology)
Source: Andrology - October 28, 2021 Category: Urology & Nephrology Tags: ISSUE INFORMATION Source Type: research

Imaging andrology of the future: Where functional imaging embraces the clinic
(Source: Andrology)
Source: Andrology - October 28, 2021 Category: Urology & Nephrology Authors: Andrea M. Isidori, Vikram S. Dogra, Paul S. Sidhu Tags: EDITORIAL Source Type: research

Prevalence of congenital cryptorchidism in Estonia
ConclusionOur data revealed that cryptorchidism prevalence, especially in full-term boys, is lower in Estonia than reported in the other Nordic-Baltic countries and worldwide.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - October 26, 2021 Category: Urology & Nephrology Authors: Viljo K übarsepp, Karin Varik, Heili Varendi, Anne Antson, Maie Veinla, Georgi Nellis, Mirjam Merila, Urve Salundi, Valve Astover, Margus Punab Tags: ORIGINAL ARTICLE Source Type: research

Berberine ameliorates erectile dysfunction in rats with streptozotocin ‐induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways
ConclusionsBBR ameliorated ED in rats with DM, possibly by improving endothelial function and inhibiting apoptosis and fibrosis by suppressing the SPHK1/S1P/S1PR2 and MAPK pathways.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - October 24, 2021 Category: Urology & Nephrology Authors: Kang Liu, Taotao Sun, Yang Luan, Yinwei Chen, Jingyu Song, Le Ling, Penghui Yuan, Rui Li, Kai Cui, Yajun Ruan, Ruzhu Lan, Tao Wang, Shaogang Wang, Jihong Liu, Ke Rao Tags: ORIGINAL ARTICLE Source Type: research

Optimum identification of round spermatid in men with non ‐obstructive azoospermia: A commentary
(Source: Andrology)
Source: Andrology - October 14, 2021 Category: Urology & Nephrology Authors: Aaron William Bradshaw, Banafsheh Nikmehr, Cihan Halicigil, Kimberly Stogner ‐Underwood, Hooman Sadri‐Ardekani Tags: LETTER TO THE EDITOR Source Type: research

Cold ‐inducible RNA‐binding protein regulates cyclin B1 against spermatogenesis arrest caused by heat stress
Conclusion: In conclusion, our results provide strong evidence that CIRBP may exert its key function in heat stress-induced testicular spermatogenic cell injury partly by regulating the expression ofCcnb1, the product of which inhibits spermatogenesis arrest.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - October 12, 2021 Category: Urology & Nephrology Authors: Heyu Liu, Chengcheng Xu, Meng Bao, Jin Huang, Liping Zou, Xiaorong Fan, Changhong Zhu, Wei Xia Tags: ORIGINAL ARTICLE Source Type: research

Assessment of the architecture and integrity of frozen ‐thawed testicular tissue from (pre)pubertal boys with cancer
AbstractBackground: Testicular tissue freezing (TTF) is proposed for fertility preservation to (pre)pubertal boys with cancer before highly gonadotoxic treatment. Studies accurately comparing human (pre)pubertal testicular tissue quality before freezing and after thawing are exceptional. No study has reported this approach in a systematic manner and routine care.Objectives: To assess the impact of a control slow freezing (CSF) protocol on testicular tissue architecture and integrity of (pre)pubertal boys after thawing.Materials and methods: (Pre)pubertal boys (n = 87) with cancer from 8 Reproductive Biology Laboratories of...
Source: Andrology - October 10, 2021 Category: Urology & Nephrology Authors: Aur élie Rives‐Feraille, Agnès Liard, Michael Bubenheim, Anne Laure Barbotin, Sandrine Giscard d'Estaing, Sophie Mirallié, Amélie Ancelle, Christophe Roux, Florence Brugnon, Cécile Grèze, Myriam Daudin, Geneviève Willson‐Plat, Rémi Tags: ORIGINAL ARTICLE Source Type: research

Androgens and estrogens predict sexual function after autologous hematopoietic stem cell transplant in men
ConclusionAndrogens and estrogens are both adversely affected by AHSCT but may predict sexual dysfunction in this population. This supports the premise that estrogen impacts sexual function independent from androgens and that steroid hormones are associated with acute changes in sexual function in this setting. Larger, controlled trials with long-term sex hormone assessment will need to confirm the association between early changes in estrogens and long-term sexual function recovery.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - October 8, 2021 Category: Urology & Nephrology Authors: Lindsey J. Anderson, Dorota Migula, Rebecca Abay, Stephanie Crabtree, Solomon A. Graf, Alvin M. Matsumoto, Thomas R. Chauncey, Jose M. Garcia Tags: ORIGINAL ARTICLE Source Type: research

Optimum identification of round spermatid in men with non ‐obstructive azoospermia, a Commentary
(Source: Andrology)
Source: Andrology - October 7, 2021 Category: Urology & Nephrology Authors: Aaron William Bradshaw, Banafsheh Nikmehr, Cihan Halicigil, Kimberly Stogner ‐Underwood, Hooman Sadri‐Ardekani Tags: LETTER TO THE EDITOR Source Type: research

Safety and efficacy of botulinum neurotoxin in the treatment of erectile dysfunction refractory to phosphodiesterase inhibitors: Results of a randomized controlled trial
AbstractBackgroundThere has been recent interest in the use of botulinum neurotoxin (BoNT) in the field of Andrology, whereby it has been investigated in the treatment of penile retraction and premature ejaculation.ObjectivesTo evaluate the safety and efficacy of intracavernosal BoNT-A injection in the treatment of patients with erectile dysfunction (ED) refractory to oral phosphodiesterase inhibitors (PDE5Is).Patients and methodsA double-blind randomized placebo-controlled prospective comparative study conducted at one center and involved 70 patients with ED refractory to PDE5Is. At baseline, the following data were colle...
Source: Andrology - October 7, 2021 Category: Urology & Nephrology Authors: Islam Fathy Soliman Abdelrahman, Amr Abdel Raheem, Yaser Elkhiat, Abdelrahman A. Aburahma, Tarek Abdel ‐Raheem, Hussein Ghanem Tags: ORIGINAL ARTICLE Source Type: research