Quercetin alleviates chronic unpredictable mild stress-induced depression-like behavior by inhibiting NMDAR1 with α2δ-1 in rats

CONCLUSIONS: Que has a good antidepressant effect and can significantly improve the depression-like behavior caused by CUMS. It exerts antidepressant effects by inhibiting the expression level of α2δ-1, interfering with the interaction between α2δ-1 and NMDAR, and then reducing the excitability of the HPA axis.PMID:38615365 | PMC:PMC11016343 | DOI:10.1111/cns.14724

Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Mingyan Wang Xin Wei Yugai Jia Chaonan Wang Xinliu Wang Xin Zhang Depei Li Yuanyuan Wang Yonggang Gao Source Type: research