The association of polymorphisms in TNF and ankylosing spondylitis in common population: a meta-analysis
ConclusionsOur meta-analysis suggests that TNF- α polymorphisms at positions − 238, − 308, − 850, − 1031 and rs769178 could have an influence on ankylosing spondylitis susceptibility in the total population. But there is no association of the TNF-376, TNF-857, TNF-863 polymorphisms with ankylosing spondylitis. Some results in the subgroups are not consistent with those in the total population. (Source: European Spine Journal)
Source: European Spine Journal - April 20, 2021 Category: Orthopaedics Source Type: research

Assessing the cone of economy in patients with spinal disease using only a force plate: an observational retrospective cohort study
AbstractStudy designThis is a retrospective cohort with multiple regression modeling.ObjectiveThe aim is to develop a new method for estimating cone of economy (CoE) using a force plate rather than traditional motion capture.BackgroundCurrently, most spinal deformity surgeons rely on static radiographic parameters for alignment, balance, and outcomes data alongside patient-reported outcome measures. The CoE, the stable region of upright posture, can be objectively measured to determine the efficiency and balance of the spine. Motion capture technology is currently used to collect data to calculate CoE, but this requires ex...
Source: European Spine Journal - April 20, 2021 Category: Orthopaedics Source Type: research

Perioperative Complications in 255 Patients Who Underwent Lateral Anterior Lumbar Interbody Fusion (LaLIF) Surgery
ConclusionThe complication rates for LaLIF are generally low and comparable to those for conventional OLIF and XLIF that have been reported in other studies. Almost all complications were transient after LaLIF. Severe complications can be avoided by using sufficient muscle relaxant, instruments with the required characteristics and vertical trajectories in multiple steps. (Source: European Spine Journal)
Source: European Spine Journal - April 19, 2021 Category: Orthopaedics Source Type: research

Surgeons preference for lumbar disk surgery: a discrete choice experiment
ConclusionIn the context of this discrete choice experiment, it is shown that neurosurgeons consider the risk of complications as most important when a surgical technique is offered to treat sciatica, while the risk of recurrent disk herniation and effectiveness are also important factors. Neurosurgeons were prepared to trade off substantial amounts of effectiveness to achieve lower complication rates. (Source: European Spine Journal)
Source: European Spine Journal - April 19, 2021 Category: Orthopaedics Source Type: research

Answer to the Letter to Editor of S. Kumar et al. concerning “Safety and effectiveness of minimally invasive scoliosis surgery for adolescent idiopathic scoliosis: a retrospective case series of 84 patients” by Yang JH, et al. (Eur Spine J [2020]; 29: 761–769)
(Source: European Spine Journal)
Source: European Spine Journal - April 19, 2021 Category: Orthopaedics Source Type: research

Adolescent idiopathic scoliosis 3D vertebral morphology, progression and nomenclature: a current concepts review
ConclusionFinally, we emphasised how a marked degree of heterogeneity exists between the included investigations, namely in scoliotic curve-type inclusion, imaging modality and timepoint of analysis within scoliosis ’ longitudinal development, and how improvement in these study design characteristics will enhance ongoing research. (Source: European Spine Journal)
Source: European Spine Journal - April 18, 2021 Category: Orthopaedics Source Type: research

Artificial intelligence clustering of adult spinal deformity sagittal plane morphology predicts surgical characteristics, alignment, and outcomes
ConclusionsThis study clustered preoperative lateral radiographs of ASD patients into groups with highly distinct overall spinal morphology and association with sagittal alignment parameters, baseline HRQOL, and surgical characteristics. The relationship between SVA and PJK differed by cluster. This study represents significant progress toward incorporation of computer vision into clinically relevant classification systems in adult spinal deformity.Level of Evidence IVDiagnostic: individual cross-sectional studies with the consistently applied reference standard and blinding. (Source: European Spine Journal)
Source: European Spine Journal - April 15, 2021 Category: Orthopaedics Source Type: research

Answer to the Letter to the Editor of K. Huang concerning “The importance of timely treatment for quality of life and survival in patients with symptomatic spinal metastases” by van Tol FR, et al. [Eur Spine J (2020): DOI 10.1007/s00586-020-06599-x]
(Source: European Spine Journal)
Source: European Spine Journal - April 13, 2021 Category: Orthopaedics Source Type: research

Letter to the editor concerning & quot;primary cervical decompression surgery may improve lumbar symptoms in patients with tandem spinal stenosis & quot; by Inoue T, et al. (Eur Spine J; 2021 jan 6. doi: 10.1007/s00586-020-06,693-0)
(Source: European Spine Journal)
Source: European Spine Journal - April 13, 2021 Category: Orthopaedics Source Type: research

Effect of lumbar laminectomy on spinal sagittal alignment: a systematic review
ConclusionsIt appears that decompression may have a small, statistically significant but probably clinically insignificant effect on lumbar lordosis, sagittal vertical axis and pelvic tilt. (Source: European Spine Journal)
Source: European Spine Journal - April 12, 2021 Category: Orthopaedics Source Type: research

Accuracy and reliability of the AO Spine subaxial cervical spine classification system grading subaxial cervical facet injury morphology
ConclusionThis study evaluates the AO Spine Classification System specifically for facet injuries involving the subaxial cervical spine in a large sample of spine surgeons. There was significant variability in diagnostic accuracy for F1 through F3-type fractures, whereas almost universal agreement was achieved for F4-type injuries. (Source: European Spine Journal)
Source: European Spine Journal - April 11, 2021 Category: Orthopaedics Source Type: research

Letter to the Editor concerning “The importance of timely treatment for quality of life and survival in patients with symptomatic spinal metastases” by van Tol FR, et al. [Eur Spine J (2020): DOI 10.1007/s00586-020–06,599-x]
(Source: European Spine Journal)
Source: European Spine Journal - April 11, 2021 Category: Orthopaedics Source Type: research

Advanced meta-analyses comparing the three surgical techniques total disc replacement, anterior stand-alone fusion and circumferential fusion regarding pain, function and complications up to 3  years to treat lumbar degenerative disc disease
AbstractPurposeThe purpose of our meta-analyses is to find the most appropriate surgical technique treating lumbar degenerative disc disease (DDD). Spinal fusion is the conventional treatment for lumbar DDD. Total disc replacement (TDR) has been developed to avoid negative effects of fusions by preserving functionality. To our knowledge, there is no evaluation comparing meta-analytically the clinical results of three different surgical techniques with same inclusion and exclusion criteria for treating DDD.MethodsThe surgical techniques TDR, anterior lumbar interbody fusion (ALIF) and circumferential fusion (CFF) are pairwi...
Source: European Spine Journal - April 10, 2021 Category: Orthopaedics Source Type: research

Correction to: A novel classification and its clinical significance in Chiari I malformation with syringomyelia based on high ‑resolution MRI
A correction to this paper has been published:https://doi.org/10.1007/s00586-021-06787-3. (Source: European Spine Journal)
Source: European Spine Journal - April 10, 2021 Category: Orthopaedics Source Type: research

Subclinical infection can be an initiator of inflammaging leading to degenerative disk disease: evidence from host-defense response mechanisms
ConclusionsThe predominance of HDRPs involved in complement cascades, neutrophil degranulation, and oxidative-stress regulation indicated an ongoing infection mediated inflammatory process in DD. Our study has documented increasing evidence for bacteria ’s role in triggering the innate immune system leading to chronic inflammation and degenerative disk disease. (Source: European Spine Journal)
Source: European Spine Journal - April 9, 2021 Category: Orthopaedics Source Type: research

Reply to the Letter to the Editor of V. Kumar et al. concerning “Primary cervical decompression surgery may improve lumbar symptoms in patients with tandem spinal stenosis” by Inoue T, et al. (Eur Spine J; 2021 Jan 6. doi: 10.1007/s00586-020–06693-0)
(Source: European Spine Journal)
Source: European Spine Journal - April 8, 2021 Category: Orthopaedics Source Type: research

Answer to the Letter to the Editor of Shen YW, et al. concerning “Complications of cervical total disc replacement and their associations with heterotopic ossification: a systematic review and meta-analysis” by N. Hui, et al. [Eur Spine J; 2020; 29(11):2688–2700]
(Source: European Spine Journal)
Source: European Spine Journal - April 7, 2021 Category: Orthopaedics Source Type: research

No evidence for an effect of working from home on neck pain and neck disability among Swiss office workers: Short-term impact of COVID-19
ConclusionThe number of work breaks and hours spent at the computer seem to have a greater effect on NP than the place of work (office, at home), measurement time point (before COVID-19, during lockdown) or the workstation ergonomics. Further research should investigate the effect of social and psychological factors.Trial registrationClinicalTrials.gov, NCT04169646. Registered 15 November 2019 —Retrospectively registered,https://clinicaltrials.gov/ct2/show/NCT04169646. (Source: European Spine Journal)
Source: European Spine Journal - April 4, 2021 Category: Orthopaedics Source Type: research

Variation in global treatment for subaxial cervical spine isolated unilateral facet fractures
ConclusionConsiderable agreement exists between surgeon preferences with regard to unilateral facet fracture management with few exceptions. F2N2 fracture subtypes and subtypes with radiculopathy (N2) appear to be the threshold for operative treatment. (Source: European Spine Journal)
Source: European Spine Journal - April 2, 2021 Category: Orthopaedics Source Type: research

Risk factors for acute proximal junctional kyphosis after adult spinal deformity surgery in preoperative motion analysis
ConclusionPreoperative Ant-PT angle during walking was associated with a higher OR in acute PJK after surgery. (Source: European Spine Journal)
Source: European Spine Journal - April 2, 2021 Category: Orthopaedics Source Type: research

Which thoracic curves are at the greater risk for distal adding-on: comparison between typical and atypical Lenke 1A curves
ConclusionAtypical Lenke 1A curve had its own radiographic characteristics. It was more likely to develop AO when LIV was proximal to LSTV, which indicated different fusion levels should be considered in these two subtypes of Lenke 1A. We recommended LSTV as LIV in atypical Lenke 1A cases, while one level proximal to LSTV might be available in typical Lenke 1A curve.Level of evidence3 (Source: European Spine Journal)
Source: European Spine Journal - March 29, 2021 Category: Orthopaedics Source Type: research

Sagittal balance of the cervical spine: a systematic review and meta-analysis
AbstractPurposeThe purpose of this systematic review and meta-analysis was to compare the cervical sagittal parameters between patients with cervical spine disorder and asymptomatic controls.MethodsTwo independent authors systematically searched online databases including Pubmed, Scopus, Cochrane library, and Web of Science up to June 2020. Cervical sagittal balance parameters, such as T1 slope, cervical SVA (cSVA), and spine cranial angle (SCA), were compared between the cervical spine in healthy, symptomatic, and pre-operative participants. Where possible, we pooled data using random-effects meta-analysis, by CMA softwar...
Source: European Spine Journal - March 27, 2021 Category: Orthopaedics Source Type: research

Scoliosis and Prognosis —a systematic review regarding patient-specific and radiological predictive factors for curve progression
AbstractIntroductionIdiopathic scoliosis, defined as a  >  10° curvature of the spine in the frontal plane, is one of the most common spinal deformities. Age, initial curve magnitude and other parameters define whether a scoliotic deformity will progress or not. Still, their interactions and amounts of individual contribution are not fully elaborated a nd were the aim of this systematic review.MethodsA systematic literature search was conducted in the common databases using MESH terms, searching for predictive factors of curve progression in adolescent idiopathic scoliosis  (“adolescent...
Source: European Spine Journal - March 26, 2021 Category: Orthopaedics Source Type: research

Percutaneous wide bore needle biopsy for spinal lesions using the kyphoplasty cannula —a technical note
ConclusionsPercutaneous transpedicular biopsy has evolved as the intervention of choice in diagnosing radiologically proven vertebral body lesions. Our technique of using a pituitary forceps through a cannula is highly effective in getting an adequate representative sample with excellent accuracy in diagnosis. This procedure is beneficial for soft tissue lesions and for infective pathology especially discitis. (Source: European Spine Journal)
Source: European Spine Journal - March 26, 2021 Category: Orthopaedics Source Type: research

The dynamics of satisfaction in surgical and non-surgical adult spinal deformity patients
ConclusionsSatisfaction does not correlate well with other PROMs, and it might be subject to other external factors not directly related to treatment. Even if patient satisfaction is important in evaluating well-being and patient ’s experience with medical care, it should not be considered as an isolated proxy to measure quality of treatment. (Source: European Spine Journal)
Source: European Spine Journal - March 22, 2021 Category: Orthopaedics Source Type: research

Variations in the position of the aorta and vertebral safe zones in supine, prone, and lateral decubitus for adolescent idiopathic scoliosis
ConclusionsPatient positioning during spinal surgery significantly modifies T4 –L4 vertebral safe zones relative to aorta. These variations should be taken into account when analyzing an MRI performed in supine if the patient is undergoing surgery in a different position, to avoid vascular-related injuries. (Source: European Spine Journal)
Source: European Spine Journal - March 22, 2021 Category: Orthopaedics Source Type: research

Better late than never: Clinical outcomes of delayed fixation in thoracolumbar spinal trauma
AbstractPurposeTo analyse factors influencing functional outcome and neurological recovery in patients undergoing delayed surgery for traumatic spinal cord injury (SCI) involving thoracolumbar spine.MethodsRetrospective analysis of 33 patients with thoracolumbar SCI who underwent delayed surgery ( ≥ 72hrs post-trauma) with a minimum follow-up of 1 year (average:32.55 months) was done. The parameters studied included age, sex, co-morbidities, mode of trauma, associated trauma, level and number of vertebrae involved, fracture morphology, thoracolumbar injury classification and severity sco re (TLICS), maximal ...
Source: European Spine Journal - March 22, 2021 Category: Orthopaedics Source Type: research

Letter to the Editor concerning “Complications of cervical total disc replacement and their associations with heterotopic ossification: a systematic review and meta-analysis” by N. Hui, et al. [Eur Spine J; 2020; 29(11):2688–2700]
(Source: European Spine Journal)
Source: European Spine Journal - March 22, 2021 Category: Orthopaedics Source Type: research

Letter to the editor concerning & quot;Handgrip strength correlates with walking in lumbar spinal stenosis & quot; by Inoue H, et al. (Eur Spine J 2020; 29: 2198 –204)
(Source: European Spine Journal)
Source: European Spine Journal - March 22, 2021 Category: Orthopaedics Source Type: research

The catastrophization effects of an MRI report on the patient and surgeon and the benefits of ‘clinical reporting’: results from an RCT and blinded trials
ConclusionRoutine MRI reports produce a negative perception and poor functional outcomes in LBP. Focussed clinical reporting had significant benefits, which calls for the need for ‘clinical reporting’ rather than ‘Image reporting’. (Source: European Spine Journal)
Source: European Spine Journal - March 21, 2021 Category: Orthopaedics Source Type: research

Minimum clinically important change for outcome scores among patients aged 75 or over undergoing lumbar spine surgery
AbstractPurposeTo elucidate the minimum clinically important change (MCIC) of the physical component summary (PCS) of the Short Form-12, Oswestry Disability Index (ODI), EuroQOL-5 dimensions (EQ-5D), and the Core Outcome Measures Index (COMI) in patients aged  ≥ 75 years undergoing lumbar spine surgery.MethodsWe retrospectively reviewed patients aged  ≥ 75 years with degenerative lumbar spine disease who underwent lumbar spine decompression or fusion surgery within three levels between April 2017 and June 2018. We also evaluated patients aged 
Source: European Spine Journal - March 20, 2021 Category: Orthopaedics Source Type: research

Vertebral bone marrow edema in magnetic resonance imaging correlates with bone healing histomorphometry in (sub)acute osteoporotic vertebral compression fracture
ConclusionsBone marrow edema significantly correlates with bone morphology parameters after vertebral fracture. The characteristics of histomorphological changes during fracture healing process can be preliminarily determined by observing the edema signal. (Source: European Spine Journal)
Source: European Spine Journal - March 20, 2021 Category: Orthopaedics Source Type: research

3D analysis of fatty infiltration of the paravertebral lumbar muscles using T2 images —a new approach
AbstractPurposeFactors influencing paraspinal muscle degeneration are still not well understood. Fatty infiltration is known to be one main feature of the degeneration cascade. The aim of this cross-sectional study was to illustrate the 3D cluster of paraspinal lumbar muscle degeneration on T2-weighted MRI images using our newly developed software application ‘iSix’.MethodsMono- (Mm. rotatores), multi- (Mm. multifidus) and pluri-segmental (M. erector spinae) lumbar muscles groups were segmented on T2-weighted MR sequences using a novel computer-assisted technique for quantitative muscle/fat discrimination. The ...
Source: European Spine Journal - March 19, 2021 Category: Orthopaedics Source Type: research

Surgical outcomes following hemivertebrectomy in congenital scoliosis: a systematic review and observational meta-analysis
AbstractBackgroundHemivertebrectomy is widely used definitive correction surgery in congenital scoliosis due to hemivertebrae. It may be done either as combined anterior and posterior approach or a single-stage posterior approach only. The purpose of this meta-analysis was to compare two techniques with regards to blood loss, operative time, deformity correction and complications.MethodsThe systematic review and  meta-analysis were conducted according to PRISMA guidelines among peer-reviewed journals published in English between June 2000 and June 2020. Quality appraisal of all selected articles was done and data extr...
Source: European Spine Journal - March 19, 2021 Category: Orthopaedics Source Type: research

New MR-based measures for the evaluation of age-related lumbar paraspinal muscle degeneration
AbstractPurposeAlthough signal intensity on T2W axial images is sensitive in detection of fatty infiltration to assess paraspinal muscle degeneration, it is affected by inhomogeneities of magnetic fields and individual variabilities. The purpose of this study was to propose reference adjusted signal measures on T2W axial images and determine their capacities in reflecting age-related lumbar paraspinal muscle degeneration.MethodsLumbar MR images of 421 population-based subjects (177 men and 244 women, mean age 53.1  years, range 19.8–87.9 years) were studied. A custom softwareSpine Explore (Tulong 2.0) was u...
Source: European Spine Journal - March 19, 2021 Category: Orthopaedics Source Type: research

Does fracture-extension into the pars interarticularis alter outcomes in odontoid failure? a technical note on pars interarticularis osteotomy and atlantoaxial distraction arthrodesis
ConclusionsOdontoid fracture with extension into the pars interarticularis often present with atlantoaxial instability and may result in stable fibrous non-union if treated non-operatively. The C1 –C2 segment can be stabilised with atlantoaxial distraction arthrodesis achieved through an osteotomy of the pars interarticularis. (Source: European Spine Journal)
Source: European Spine Journal - March 18, 2021 Category: Orthopaedics Source Type: research

Bracing adults with chronic low back pain secondary to severe scoliosis: six months results of a prospective pilot study
AbstractPurposeAdult scoliosis is sometimes associated with back pain and severe curves can progress over time. Despite scoliosis has been estimated to affect up to 68% of the population over 60, there is scant literature about conservative treatment for adult scoliosis. Recently, we tested a new brace designed to alleviate pain for adult patients with chronic pain secondary to scoliosis. The study aims to test the efficacy of a prefabricated brace in reducing pain in adult scoliosis patients.MethodsTwenty adults (age 67.8  ± 10.5, curve 61.9 ± 12.6° Cobb) with chronic low back...
Source: European Spine Journal - March 17, 2021 Category: Orthopaedics Source Type: research

Long-term outcome of targeted therapy for low back pain in elderly degenerative lumbar scoliosis
ConclusionBone marrow lesions of the endplate are strongly associated with the presence of LBP. PIPI can be considered as an effective, safe and repeatable treatment for LBP in elderly DLS patients. (Source: European Spine Journal)
Source: European Spine Journal - March 17, 2021 Category: Orthopaedics Source Type: research

Announcement
(Source: European Spine Journal)
Source: European Spine Journal - March 17, 2021 Category: Orthopaedics Source Type: research

Georg Schmorl Prize of the German Spine Society (DWG) 2020: new biomechanical in vitro test method to determine subsidence risk of vertebral body replacements
ConclusionIn this study, a new biomechanical test method was developed that simulates physiologic activities to examine implant subsidence. It appears that the highest risk of subsidence occurs most when lifting heavy weights, and into the ventral part of the caudal vertebra. The results indicate that lateral end pieces may better prevent from implant subsidence because of the additional cortical support. Generally, patients that are treated with a VBR should avoid activities that create high loading on the spine. (Source: European Spine Journal)
Source: European Spine Journal - March 17, 2021 Category: Orthopaedics Source Type: research

Is fresh, leucodepleted, whole blood transfusion superior to blood component transfusion in pediatric patients undergoing spinal deformity surgeries? A prospective, randomized study analyzing postoperative serological parameters and clinical recovery
AbstractPurposeTo compare the effectiveness of fresh whole blood (FWB) and blood component transfusion in improving clinical outcome and serological parameters in the early postoperative period following spinal deformity surgery.MethodsPatients undergoing major spinal deformity surgeries involving  ≥ 6 levels of fusion and expected blood loss ≥ 750 ml between September 2017 and August 2018 were included in the study. The patients were randomized into two groups: FWBG and CG, receiving fresh whole blood and component transfusions, respectively.ResultsA total of 65 patients with spinal ...
Source: European Spine Journal - March 16, 2021 Category: Orthopaedics Source Type: research

What determines immediate postoperative coronal balance and delayed global coronal balance after anterior spinal fusion for Lenke 5C curves?
AbstractPurposeTo determine the factors associated with 6-week postoperative global coronal balance and delayed global coronal balance at 2-year follow-up after anterior spinal fusion for Lenke 5C curves.MethodsA total of 124 consecutive Lenke 5C curves with minimum 2-year follow-up was studied. Radiographic parameters were studied preoperatively, 6 weeks postoperatively, and 2  years postoperatively. Coronal balance was measured by C7-CSVL and trunk shift 
Source: European Spine Journal - March 15, 2021 Category: Orthopaedics Source Type: research

Answer to the Letter to the Editor of Xu C, et al. concerning “Implementation of enhanced recovery after surgery (ERAS) protocol for anterior cervical discectomy and fusion: a propensity score-matched analysis” by Debono B et al. [Eur Spine J (2020): DOI 10.1007/s00586-020-06445-0]
(Source: European Spine Journal)
Source: European Spine Journal - March 15, 2021 Category: Orthopaedics Source Type: research

Prospective investigation of Oswestry Disability Index and short form 36 subscale scores related to sagittal and coronal parameters in patients with degenerative lumbar scoliosis
ConclusionsODI total score and most of the subscale scores were significantly, but weakly correlated with coronal parameters. Sagittal parameters were only correlated with some of the ODI and SF-36 subscale scores. Analysis using ODI and SF-36 subscale scores may aid in understanding and treatment of disability in patients with DLS. (Source: European Spine Journal)
Source: European Spine Journal - March 14, 2021 Category: Orthopaedics Source Type: research

The reaction times and symmetry indices in the bilateral trunk and limb muscles in control subjects and subjects with low back pain that persisted two months or longer
ConclusionThe delayed non-dominant ES reaction time might indicate a freedom of pain recurrence in the control group. Although the asymmetry increased on the RA and BB muscles in the LBP group, it decreased on the ES muscle. The asymmetries on the trunk and BB muscles were evident in the LBP group.  The asymmetrical reactions in the arm-trunk muscles need to be considered for rehabilitation strategies. (Source: European Spine Journal)
Source: European Spine Journal - March 13, 2021 Category: Orthopaedics Source Type: research

Real-time ultrasound-computed tomography image fusion for transforaminal lumbar approach: a lumbosacral spine phantoms study
AbstractPurposeUltrasound (US) is increasingly used for transforaminal approaches. We evaluated whether fusing computed tomography (CT) images with dynamic US could be based on bony and surface landmarks in two phantom models.MethodsRecordings were performed in a gelatin-based sonographic phantom and in a computerized imaging reference system training phantom. Three anesthesiologists performed 10 US and CT image fusions via three different techniques: (1) using locations of the fifth lumbar vertebra (L5) spinous process and the two posterior superior iliac spines in both images, (2) using the two lateral edges of the lamin...
Source: European Spine Journal - March 13, 2021 Category: Orthopaedics Source Type: research

Answer to the Letter to the Editor of P. Missori et al. concerning “Rotational vertebral artery occlusion ('bow hunter syndrome')” by Schulz R, Donoso R, Weissman K (Eur Spine J; 2021 Jan 2. https://doi.org/10.1007/s00586-020-06680-5)
(Source: European Spine Journal)
Source: European Spine Journal - March 12, 2021 Category: Orthopaedics Source Type: research

A novel surgical protocol for safe and accurate placement of C1 lateral mass screws in patients with atlas assimilation, basilar invagination and atlantoaxial instability: technical details, accuracy assessment and perioperative complications
ConclusionPlacement of C1 lateral mass screws in patients with atlas assimilation, basilar invagination and atlantoaxial instability following this surgical protocol is safe and accurate. Thorough para-odontoid ligamental release, wide exposure of the invaginated lateral mass, and diligent protection of the vertebral artery are critical to maximize the chances of successful screw placement. (Source: European Spine Journal)
Source: European Spine Journal - March 11, 2021 Category: Orthopaedics Source Type: research

Sonic Hedgehog modulates the inflammatory response and improves functional recovery after spinal cord injury in a thoracic contusion –compression model
AbstractPurposeThe Sonic Hedgehog (Shh) pathway has been associated with a protective role after injury to the central nervous system (CNS). We, therefore, investigated the effects of intrathecal Shh-administration in the subacute phase after thoracic spinal cord injury (SCI) on secondary injury processes in rats.MethodsTwenty-one Wistar rats were subjected to thoracic clip-contusion/compression SCI at T9. Animals were randomized into three treatment groups (Shh, Vehicle, Sham). Seven days after SCI, osmotic pumps were implanted for seven-day continuous intrathecal administration of Shh. Basso, Beattie and Bresnahan (BBB) ...
Source: European Spine Journal - March 11, 2021 Category: Orthopaedics Source Type: research

Correlation between different instrumentation variants and the degree of destabilization in treating cervical spondylotic spinal canal stenosis by unilateral hemilaminectomy with bilateral decompression: a biomechanical investigation
ConclusionBilateral decompression via a hemilaminectomy, even if combined with foraminotomy, could be a less invasive treatment option for multilevel CSM in patients with lordotic cervical alignment and absence of segmental instability. (Source: European Spine Journal)
Source: European Spine Journal - March 10, 2021 Category: Orthopaedics Source Type: research