Claustrum projections to the anterior cingulate modulate nociceptive and pain-associated behavior

In this study, we sought to define claustrum function in acute and chronic pain. We found enhanced claustrum activity after a painful stimulus that was attenuated in chronic inflammatory pain. Selective inhibition of claustrocingulate projection neurons enhanced acute nociception but blocked pain learning. Inversely, chemogenetic activation of claustrocingulate neurons had no effect on basal nociception but rescued inflammation-induced mechanical allodynia. Together, these results suggest that claustrocingulate neurons are a critical component of the pain neuromatrix, and dysregulation of this connection may contribute to chronic pain.PMID:38614081 | DOI:10.1016/j.cub.2024.03.044
Source: Current Biology - Category: Biology Authors: Source Type: research