The molecular arrangement of ceramides in the unit cell of the long periodicity phase of stratum corneum models shows a high adaptability to different ceramide head group structures
In this study, the impact of the CER head group structure on the lipid arrangement and barrier functionality was investigated using lipid models forming the LPP. The results demonstrate that the positions of CER N-(tetracosanoyl)-sphingosine (CER NS) and CER N-(tetracosanoyl)-phytosphingosine (CER NP), two essentials CER subclasses, are not influenced by the addition of another CER subclass (N-(tetracosanoyl)-dihydrosphingosine (CER NdS), N-(2R-hydroxy-tetracosanoyl)-sphingosine (CER AS) or D-(2R-hydroxy-tetracosanoyl)-phytosphingosine (CER AP)). However, differences are observed in the lipid organization and the hydrogen ...
Source: Biochimica et Biophysica Acta - April 30, 2024 Category: Biochemistry Authors: Andreea N ădăban Gerrit S Gooris Charlotte M Beddoes Robert M Dalgliesh Marc Malfois Bruno Dem é Joke A Bouwstra Source Type: research
Glycemic and lipid control in patients with diabetes at time of myocardial infarction
CONCLUSION: We highlighted the poor glycemic and lipid control in high-risk CV patients. There is an urgent need to develop multidisciplinary approaches to optimize CV risk factors control to reduce myocardial infarction and strokes.PMID:38685473 | DOI:10.1016/j.pharma.2024.04.010 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - April 30, 2024 Category: Drugs & Pharmacology Authors: Christelle Lacqua H éloïse Adam Marianne Zeller Lucie Vadot Florence Bichat Maud Maza Yves Cottin Mathieu Boulin Source Type: research
Endogenous Protein-Protein Interaction Network of the NPC Cholesterol Transporter 1 in the Cerebral Cortex
J Proteome Res. 2024 Apr 30. doi: 10.1021/acs.jproteome.3c00788. Online ahead of print.ABSTRACTNPC intracellular cholesterol transporter 1 (NPC1) is a multipass, transmembrane glycoprotein mostly recognized for its key role in facilitating cholesterol efflux. Mutations in the NPC1 gene result in Niemann-Pick disease, type C (NPC), a fatal, lysosomal storage disease. Due to the progressively expanding implications of NPC1-related disorders, we investigated endogenous NPC1 protein-protein interactions in the mouse cortex and human-derived iPSCs neuronal models of the disease through coimmunoprecipitation-coupled with LC-MS b...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Roshan Javanshad Thu T A Nguyen Ruth D Azaria Wenping Li Daisy Edmison Liang-Wei Gong Swetha Gowrishankar Andrew P Lieberman Mark L Schultz Stephanie M Cologna Source Type: research
Effects of priming glycosyltransferase genes cps 2E and cps 4E on the exopolysaccharide biosynthesis by Lactiplantibacillus plantarum YM-4-3 strain
In conclusion, this study contributes to the efficient production and application of L. plantarum EPS and helps to understand the mechanism of EPS regulation in L. plantarum.PMID:38685537 | DOI:10.1016/j.ijbiomac.2024.131813 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Tian Wang Yong-Gang Xiong Tian-Zhao Si Jin-Ping Yan Xiao-Ran Li Chen-Jian Liu En Yang Source Type: research
Assessing the influence of micelle silymarin on laying hens' performance, egg quality, water loss and blood profile
AbstractMicelle silymarin (MS) is known for its various beneficial properties, including antiswelling, antioxidant, hepatoprotective and antidiabetic effects. The primary goal of this research was to investigate how MS impacts the performance, egg quality, water loss and blood profile of laying hens. 288 Hy-Line brown laying hens, 28 weeks in age, were utilized for this experiment. The hens were randomly allocated into three dietary treatment groups, with each group comprising eight replicates of 12 hens, each housed in individual pens with access to feed and water. Over a 12-week feeding trial, the hens were provided with...
Source: Journal of Animal Physiology and Animal Nutrition - April 30, 2024 Category: Zoology Authors: Golam S. Ahammad,
Yong H. Jeon,
In H. Kim Tags: ORIGINAL ARTICLE Source Type: research
GSE260557 Cytotoxic Sigma-2 Ligands Trigger Cancer Cell Death via Cholesterol-Induced-ER-Stress
Contributors : Rony Takchi ; Bethany C Prudner ; Qingqing Gong ; Takaomi Hagi ; Kenneth F Newcomer ; Linda X Jin ; Suwanna Vangveravong ; Brian A Van Tine ; William G Hawkins ; Dirk SpitzerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSigma-2-ligands (S2L) are characterized by high-affinity interaction with their cognate sigma-2 receptor, overexpressed in rapidly proliferating tumor cells. As such, S2L were developed as imaging probes (ISO1) or as cancer therapeutics, alone (SV119 [C6], SW43 [C10]) and as delivery vehicles for cytotoxic drug cargoes following chemical conjugati...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Unsupervised Machine Learning Revealed that Repeat Transcranial Magnetic Stimulation is More Suitable for Stroke Patients with Statin
ConclusionStroke patients undergoing rTMS treatment taking statins exhibited greater MEP, FFO, and changes in FMA. Statin intake was associated with a better prognosis in these patients. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 30, 2024 Category: Neurology Source Type: research
Association between pre-treatment with statin and its inhibitory effect on the onset of coronary artery disease at the time of coronary computed tomography angiography: a new look at an old medication
In this study, we investigated whether pre-treatment with statin could significantly inhibit the onset of CAD when patients received CCTA for screening of CAD. The subjects were 1164 patients who underwent CCTA as screening for CAD. CAD was diagnosed when 50% or more coronary stenosis was present in the coronary arteries. Patient backgrounds were investigated by age, gender, body mass index, coronary risk factors [family history of cardiovascular diseases, smoking history, hypertension (HTN), diabetes mellitus (DM), dyslipidemia, chronic kidney disease (CKD) or metabolic sydrome] and medications. Patients were classified i...
Source: Heart and Vessels - April 30, 2024 Category: Cardiology Source Type: research
Letter to editor: Prophylactic use of statins in HIV patients: Better be safe than sorry
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 30, 2024 Category: General Medicine Source Type: research
Social inequality in prevalence of NCD risk factors: a cross-sectional analysis from the population-based Tromso Study 2015-2016
Conclusion
We found statistically significant educational gradients in women and men for all WHO-established leading NCD risk factors within a Nordic middle-aged to older general population. The prevalence of all risk factors increased at lower educational levels, except for harmful alcohol use, which increased at higher educational levels. (Source: BMJ Open)
Source: BMJ Open - April 30, 2024 Category: General Medicine Authors: Hetland, R. A., Wilsgaard, T., Hopstock, L. A., Ariansen, I., Johansson, J., Jacobsen, B. K., Grimsgaard, S. Tags: Open access, Epidemiology Source Type: research
The Effects of Alpha Linolenic Acid (Omega-3 Fatty Acid) on Tobacco Craving Intensity, Withdrawal Symptoms and Biochemical Markers in Tobacco Users
This study was registered at Clinical Trial Registry-India (http://www.ctri.nic.in) with reference no. CTRI202202040681 and was performed in accordance with the Declaration of Helsinki principles. (Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - April 30, 2024 Category: Biochemistry Source Type: research
Effect of Perilla seeds inclusion on the performance, egg quality characteristics, biochemical parameters and egg yolk fatty acid composition of laying hens
This study investigates the effect of supplementation of Perilla seeds (PS) on the performance, egg quality, blood biochemical parameters, and egg yolk fatty acids composition in the diet of egg-laying chicken. A total of 1600 Lohmann laying hens were randomly assigned to four different groups with 4 replicates each (100 chickens/replicate) and were subjected to varying PS concentrations (PS0, PS6, PS12, and PS18; 0%, 6%, 12%, and 18%, respectively) for four weeks, including an acclimation period of one week. The results showed no significant differences among the groups for average egg weight(P > 0.005). The layin...
Source: Tropical Animal Health and Production - April 30, 2024 Category: Veterinary Research Source Type: research
Relationship of device measured physical activity type and posture with cardiometabolic health markers: pooled dose –response associations from the Prospective Physical Activity, Sitting and Sleep Consortium
Conclusions/interpretationIn this first activity type-specific analysis of device-based physical activity, ~64 min/day of walking and ~5.0 min/day of stair climbing were associated with a favourable cardiometabolic risk profile. The deleterious associations of sitting time were fully attenuated after exclusion of participants with prevalent CVD and medication use. Our findings on cardiometabolic health and durations of different activities of daily living and posture may guide future interventions involving lifestyle modification.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - April 29, 2024 Category: Endocrinology Source Type: research
Pharmacotherapeutic Potential of Bitter Gourd ( < em > Momordica charantia < /em > ) in Age-related Neurological Diseases
J Integr Neurosci. 2024 Apr 23;23(4):86. doi: 10.31083/j.jin2304086.ABSTRACTDue to the growth of the elderly population, age-related neurological disorders are an increasing problem. Aging begins very gradually and later leads to several neurological issues such as lower neurotransmitter levels, oxidative stress, neuronal inflammation, and continual neuronal loss. These changes might contribute to brain disorders such as Alzheimer's disease (AD), dementia or mild cognitive impairment, and epilepsy and glioma, and can also aggravate these disorders if they were previously present. Momordica charantia (bitter gourd), a membe...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Seyed Mohammad Hosein Hosseini Adarmanabadi Orod Jalali Khalil Abadi Amirhossein Amiri Rozhina Tamannaeifar Sahar Balanian Mehdi Rasekhjam Mohammad Sadra Samiazar Sara Hasanpour Samira Peiravi Dorsa Alijanzadeh Mohadeseh Poudineh Hamidreza Amiri Seyed Ami Source Type: research
Association between Lipid-Lowering Drugs and Traumatic Subdural Hemorrhage: A Mendelian Randomization Study
CONCLUSIONS: This two-sample MR study suggests a potential causal relationship between HMGCR inhibition (atorvastatin) and traumatic subdural hemorrhage.PMID:38682216 | DOI:10.31083/j.jin2304076 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Kaiqin Chen He Li Yongtai Chen Hesen Huang Liangfeng Wei Source Type: research
