Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease
Conclusions/interpretationLow body size in childhood exacerbates the risk of type 2 diabetes associated with adult obesity but not the risk of cardiovascular disease. Thus, promoting healthy weight management from childhood to adulthood, among lean children, is crucial.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - March 20, 2024 Category: Endocrinology Source Type: research
Glucose tolerance and insulin resistance/sensitivity associate with retinal layer characteristics: the LIFE-Adult-Study
Conclusions/interpretationAn impaired glucose homeostasis associates with a thinning of the optical bands of retinal ONL and photoreceptor MZ. Changes in ONL and MZ thicknesses might predict early metabolic retinal alterations in diabetes.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - March 20, 2024 Category: Endocrinology Source Type: research
Harnessing the power of proteomics in precision diabetes medicine
AbstractPrecision diabetes medicine (PDM) aims to reduce errors in prevention programmes, diagnosis thresholds, prognosis prediction and treatment strategies. However, its advancement and implementation are difficult due to the heterogeneity of complex molecular processes and environmental exposures that influence an individual ’s disease trajectory. To address this challenge, it is imperative to develop robust screening methods for all areas of PDM. Innovative proteomic technologies, alongside genomics, have proven effective in precision cancer medicine and are showing promise in diabetes research for potential translat...
Source: Diabetologia - March 20, 2024 Category: Endocrinology Source Type: research
Critical comments regarding the assessment of quality of life and the clinical impact of the POWER2DM intervention
(Source: Diabetologia)
Source: Diabetologia - March 20, 2024 Category: Endocrinology Source Type: research
Up Front
(Source: Diabetologia)
Source: Diabetologia - March 20, 2024 Category: Endocrinology Source Type: research
Critical comments regarding the assessment of quality of life and the clinical impact of the POWER2DM intervention. Reply to Pouwer F, Desch ênes SS [letter]
(Source: Diabetologia)
Source: Diabetologia - March 20, 2024 Category: Endocrinology Source Type: research
Genome-wide association and Mendelian randomisation analysis among 30,699 Chinese pregnant women identifies novel genetic and molecular risk factors for gestational diabetes and glycaemic traits
Conclusions/interpretationOur findings provide new insights into the genetic basis of GDM and glycaemic traits during pregnancy in an East Asian population and highlight the potential role of inflammatory pathways in the aetiology of GDM and variations in glycaemic levels.Data availabilitySummary statistics for GDM; fasting plasma glucose; 0 h, 1 h and 2h OGTT; and the 55 biomarkers are available in the GWAS Atlas (study accession no.: GVP000001,https://ngdc.cncb.ac.cn/gwas/browse/GVP000001).Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - March 4, 2024 Category: Endocrinology Source Type: research
Acculturation and glycaemic control in Arab immigrants with type 2 diabetes in Australia
Conclusions/interpretationAmong Arab immigrants in Australia with type 2 diabetes, the degree of acculturation is related to glycaemic control, suggesting possible avenues for new interventions.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - March 4, 2024 Category: Endocrinology Source Type: research
Early-childhood body mass index and its association with the COVID-19 pandemic, containment measures and islet autoimmunity in children with increased risk for type 1 diabetes
Conclusions/interpretationEarly-childhood BMI increased during the COVID-19 pandemic, and was influenced by the level of restrictions during the pandemic. Controlling for the COVID-19 pandemic, elevated BMI during early childhood was associated with increased risk for childhood islet autoimmunity in children with genetic susceptibility to type 1 diabetes.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - March 4, 2024 Category: Endocrinology Source Type: research
Autoimmune comorbidity in type 1 diabetes and its association with metabolic control and mortality risk in young people: a population-based study
Conclusions/interpretationTo our knowledge, this is the first comprehensive study where young individuals with type 1 diabetes were followed regarding development of a wide spectrum of autoimmune diseases, from onset of type 1 diabetes. In this nationwide and population-based study, there was already a high prevalence of autoimmune diseases in childhood, especially coeliac and thyroid disease. The presence of autoimmune comorbidity did not have a statistically significant effect on metabolic control or mortality risk.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - March 4, 2024 Category: Endocrinology Source Type: research
Remission of type 2 diabetes: always more questions, but enough answers for action
AbstractThe concept of type 2 diabetes remission is evolving rapidly, and gaining wide public and professional interest, following demonstration that with substantial intentional weight loss almost nine in ten people with type 2 diabetes can reduce their HbA1c level below the diagnostic criterion (48 mmol/mol [6.5%]) without glucose-lowering medications, and improve all features of the metabolic syndrome. Pursuing nomoglycaemia with older drugs was dangerous because of the risk of side effects and hypoglycaemia, so the conventional treatment target was an HbA1c concentration of 53 mmol/mol (7%), meaning that diabetes was s...
Source: Diabetologia - March 4, 2024 Category: Endocrinology Source Type: research
Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1 α
Conclusions/interpretationOur results demonstrate an essential role for TET3 in the regulation of skeletal muscle insulin sensitivity and suggest that TET3 may be used as a potential therapeutic target for the metabolic syndrome.Data availabilitySequences are available from the Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo/) with accession number of GSE224042.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - March 4, 2024 Category: Endocrinology Source Type: research
Disease severity-based subgrouping of type 2 diabetes does not parallel differences in quality of life: the Maastricht Study
Conclusions/interpretationDisease severity suggested by the clusters of type 2 diabetes is not entirely reflected in quality of life. In particular, the MOD cluster does not appear to be moderate in terms of quality of life. Use of the suggested cluster names in practice should be carefully considered, as the non-neutral nomenclature may affect disease perception in individuals with type 2 diabetes and their healthcare providers.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - March 4, 2024 Category: Endocrinology Source Type: research
Progression of type 1 diabetes is associated with high levels of soluble PD-1 in islet autoantibody-positive children
Conclusions/interpretationThis study reveals an sICM profile that is dysregulated during the preclinical stage of type 1 diabetes, and identifies sPD-1 as a pathophysiologically-relevant molecule that is associated with disease progression, offering a potential target for early interventions in autoimmune diabetes.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - March 4, 2024 Category: Endocrinology Source Type: research
Up Front
(Source: Diabetologia)
Source: Diabetologia - March 4, 2024 Category: Endocrinology Source Type: research
