Exploring of gut microbiota features in dyslipidemia and chronic coronary syndrome patients undergoing coronary angiography
The objective of this study was to study the diversity and composition of gut microbiota and related clinical parameters among CCS patients undergoing coronary angiography and dyslipidemia patients in comparison to healthy volunteers in Thailand. CCS patients had more risk factors and higher inflammatory markers, high-sensitivity C-reactive protein (hs-CRP) than others. The alpha diversity was lower in dyslipidemia and CCS patients than in the healthy group. A significant difference in the composition of gut microbiota was observed among the three groups. The relative abundance of Proteobacteria, Fusobacteria, Enterobacter...
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Wongsakorn Luangphiphat Pinidphon Prombutara Viroj Muangsillapasart Damrong Sukitpunyaroj Eric Eeckhout Malai Taweechotipatr Source Type: research
Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis
Nat Cardiovasc Res. 2023 Nov;2(11):1015-1031. doi: 10.1038/s44161-023-00354-3. Epub 2023 Oct 30.ABSTRACTAtherosclerosis is driven by the expansion of cholesterol-loaded 'foamy' macrophages in the arterial intima. Factors regulating foamy macrophage differentiation and survival in plaque remain poorly understood. Here we show, using trajectory analysis of integrated single-cell RNA sequencing data and a genome-wide CRISPR screen, that triggering receptor expressed on myeloid cells 2 (Trem2) is associated with foamy macrophage specification. Loss of Trem2 led to a reduced ability of foamy macrophages to take up oxidized low-...
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Michael T Patterson Maria M Firulyova Yingzheng Xu Hannah Hillman Courtney Bishop Alisha Zhu Grant H Hickok Patricia R Schrank Christine E Ronayne Zakariya Caillot Gavin Fredrickson Ainsley E Kennedy Nisha Acharya Jaap G Neels Giulia Chinetti Xavier Revel Source Type: research
Endothelial dysfunction in vascular complications of diabetes: a comprehensive review of mechanisms and implications
Front Endocrinol (Lausanne). 2024 Apr 5;15:1359255. doi: 10.3389/fendo.2024.1359255. eCollection 2024.ABSTRACTDiabetic vascular complications are prevalent and severe among diabetic patients, profoundly affecting both their quality of life and long-term prospects. These complications can be classified into macrovascular and microvascular complications. Under the impact of risk factors such as elevated blood glucose, blood pressure, and cholesterol lipids, the vascular endothelium undergoes endothelial dysfunction, characterized by increased inflammation and oxidative stress, decreased NO biosynthesis, endothelial-mesenchym...
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Dong-Rong Yang Meng-Yan Wang Cheng-Lin Zhang Yu Wang Source Type: research
Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis
Nat Cardiovasc Res. 2023 Nov;2(11):1015-1031. doi: 10.1038/s44161-023-00354-3. Epub 2023 Oct 30.ABSTRACTAtherosclerosis is driven by the expansion of cholesterol-loaded 'foamy' macrophages in the arterial intima. Factors regulating foamy macrophage differentiation and survival in plaque remain poorly understood. Here we show, using trajectory analysis of integrated single-cell RNA sequencing data and a genome-wide CRISPR screen, that triggering receptor expressed on myeloid cells 2 (Trem2) is associated with foamy macrophage specification. Loss of Trem2 led to a reduced ability of foamy macrophages to take up oxidized low-...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Michael T Patterson Maria M Firulyova Yingzheng Xu Hannah Hillman Courtney Bishop Alisha Zhu Grant H Hickok Patricia R Schrank Christine E Ronayne Zakariya Caillot Gavin Fredrickson Ainsley E Kennedy Nisha Acharya Jaap G Neels Giulia Chinetti Xavier Revel Source Type: research
The effects of jujube (Ziziphus jujube) on metabolic and mental health outcomes in patients with metabolic syndrome: A randomized controlled trial
CONCLUSION: Jujube consumption only had beneficial effects on WC, TG, and HDL-C in subjects with MetS. However, the current study has methodological weaknesses in blinding and herb purity/potency testing, which should be addressed in future studies.TRIAL REGISTRATION: Iranian Registry of Clinical Trials (registration number: IRCT20180201038585N10; registration date: 11 April 2021), https://www.irct.ir/trial/55287.PMID:38648942 | DOI:10.1016/j.ctim.2024.103041 (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - April 22, 2024 Category: Complementary Medicine Authors: Karim Parastouei Saad Badai Nashtar Zaid Al-Attar Parivash Shekarchizadeh-Esfahani Gholamreza Askari Source Type: research
Induction of hepatic CYP3A4 expression by cholesterol and cholic acid: Alterations of gene expression, microsomal activity, and pharmacokinetics
In conclusion, our study suggested that hepatic CYP3A4 expression and activity are influenced by the combination of cholesterol and cholic acid in vivo. (Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - April 22, 2024 Category: Drugs & Pharmacology Authors: Genki Minegishi,
Yuka Kobayashi,
Mayu Fujikura,
Ayane Sano,
Yasuhiro Kazuki,
Kaoru Kobayashi Tags: ORIGINAL ARTICLE Source Type: research
Influence of Low-Density Lipoprotein Cholesterol Levels on NSAID-Associated Cardiovascular Risks After Myocardial Infarction: A Population-Based Cohort Study
(Source: Clinical Epidemiology)
Source: Clinical Epidemiology - April 22, 2024 Category: Epidemiology Tags: Clinical Epidemiology Source Type: research
Layered plaque is associated with high levels of vascular inflammation and vulnerability in patients with stable angina pectoris
AbstractLayered plaque, a signature of previous plaque destabilization and healing, is a known predictor for rapid plaque progression; however, the mechanism of which is unknown. The aim of the current study was to compare the level of vascular inflammation and plaque vulnerability in layered plaques to investigate possible mechanisms of rapid plaque progression. This is a retrospective, observational, single-center cohort study. Patients who underwent both coronary computed tomography angiography (CTA) and optical coherence tomography (OCT) for stable angina pectoris (SAP) were selected. Plaques were defined as any tissue...
Source: Journal of Thrombosis and Thrombolysis - April 22, 2024 Category: Hematology Source Type: research
Remnant cholesterol is an effective biomarker for predicting survival in patients with breast cancer
This study inve... (Source: Nutrition Journal)
Source: Nutrition Journal - April 22, 2024 Category: Nutrition Authors: Jinyu Shi, Tong Liu, Chenan Liu, Heyang Zhang, Guotian Ruan, Hailun Xie, Shiqi Lin, Xin Zheng, Yue Chen, Qi Zhang, Xiaowei Zhang, Xiangrui Li, Xiaoyue Liu, Li Deng and Han-Ping Shi Tags: Research Source Type: research
The increasing importance of lipid lowering therapies as a part of the ‘first medical contact’ in patients with acute coronary syndrome
Considering advances in the treatment of patients with acute coronary syndrome (ACS), ischemic relapses still occur within two years in up to 20% of these patients, and need to develop alternative strategies to reduce the long-term risks of ACS patients is highlighted in this recently published article [1]. Nelles et al. stated that cholesterol crystals (CCs) represent a high-risk structure that frequently occurs in culprit lesions in ACS. The results of this study demonstrated that CCs are associated with increased inflammation as well as the classic fragility features of atherosclerotic plaque. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 22, 2024 Category: Cardiology Authors: Ercan Ak şit, Uğur Küçük, Bahadır Kırılmaz Source Type: research
Rare genetic cerebrotendinous xanthomatosis cases (CTX) without cholestanol elevation but with prominent cholesterol-rich tendon xanthomas.
Cerebrotendinous xanthomatosis (CTX) is a rare disease attributed to partial or complete loss of the enzyme sterol-27-hydroxylase leading to chenodeoxycholic acid and cholic acid production deficiency, and accumulation of sterol intermediates, mainly cholestanol, in plasma and in several other tissues. The clinical phenotype of CTX greatly varies among patients and includes tendon xanthomas, gallbladder stones, diarrhea, cataracts, and neurological abnormalities 1. The diagnostic identification typically is characterized by an elevated level of plasma cholestanol and identification of CYP27A1 gene variants. (Source: Journa...
Source: Journal of Clinical Lipidology - April 22, 2024 Category: Lipidology Authors: Renato Jorge Alves, Val éria Sutti Nunes, Ney Carter do Carmo Borges Junior, Edna Regina Nakandakare, Eder Carlos Rocha Quintão Tags: Case Study Source Type: research
Assessing the causal associations of different types of statins use and knee/hip osteoarthritis: A Mendelian randomization study
This study comprehensively evaluated the causal relationship between different types of statins use and knee/hip osteoarthritis (OA) using a two-sample and multivariate Mendelian randomization (MR) method. MethodsMR analysis was conducted using publicly available summary statistics data from genome-wide association studies (GWAS) to assess the causal associations between total statins use (including specific types) and knee/hip OA. The primary analysis utilized the inverse variance-weighted (IVW) method, with sensitivity analysis conducted to assess robustness. Multivariable MR (MVMR) analysis adjusted for low-density lipo...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Xin Chen Source Type: research
A high-dose of ursodeoxycholic acid treatment alleviates liver inflammation by remodeling gut microbiota and bile acid profile in a mouse model of non-alcoholic steatohepatitis
In conclusion, a high dosage of UDCA can alleviate liver inflammation, probably by modifying the composition of gut microbiota and serum bile acid profiles in NASH mice.PMID:38643542 | DOI:10.1016/j.biopha.2024.116617 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Hu Li Mingjie Wang Peizhan Chen Mingyu Zhu Li Chen Source Type: research
Rice proteins: A review of their extraction, modification techniques and applications
Int J Biol Macromol. 2024 Apr 21;268(Pt 1):131705. doi: 10.1016/j.ijbiomac.2024.131705. Online ahead of print.ABSTRACTRice protein is highly nutritious and easy to digest and absorb. Its hydrolyzed peptides have significant effects on lowering blood pressure and cholesterol. First, a detailed and comprehensive explanation of rice protein extraction methods was given, and it was found that the combination of enzymatic and physical methods could improve the extraction rate of rice protein, but it was only suitable for laboratory studies. Second, the methods for improving the functional properties of rice protein were introdu...
Source: International Journal of Biological Macromolecules - April 21, 2024 Category: Biochemistry Authors: Li Zheng Yue San Yuejiao Xing Joe M Regenstein Source Type: research
A high-dose of ursodeoxycholic acid treatment alleviates liver inflammation by remodeling gut microbiota and bile acid profile in a mouse model of non-alcoholic steatohepatitis
In conclusion, a high dosage of UDCA can alleviate liver inflammation, probably by modifying the composition of gut microbiota and serum bile acid profiles in NASH mice.PMID:38643542 | DOI:10.1016/j.biopha.2024.116617 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Hu Li Mingjie Wang Peizhan Chen Mingyu Zhu Li Chen Source Type: research
