Pre β1-HDL metabolism is delayed in patients with chronic kidney disease not on hemodialysis
Pre β1-high-density lipoprotein (HDL) is a lipid-poor cholesterol acceptor that is converted to lipid-rich HDL by lecithin-cholesterol acyltransferase (LCAT). In hemodialysis patients, preβ1-HDL metabolism is hampered even if HDL-cholesterol is normal. Hemodialysis may affect preβ1-HDL metabolism by releasing lipases from the vascular wall due to heparin. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - August 5, 2020 Category: Lipidology Authors: Kotoko Yamatani, Satoshi Hirayama, Utako Seino, Akiko Hirayama, Atsushi Hori, Koya Suzuki, Mayumi Idei, Masaki Kitahara, Takashi Miida Tags: Original Research Source Type: research

Associations of GlycA and High-Sensitivity C-Reactive Protein with Measures of Lipolysis in Adults with Obesity
Obesity-associated inflammation promotes metabolic dysfunction. However, it is unclear how different inflammatory biomarkers predict dysregulation in specific tissues/organs, particularly adipose tissue. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - August 4, 2020 Category: Lipidology Authors: Jordan A. Levine, Jung Min Han, Anna Wolska, Sierra R. Wilson, Tushar P. Patel, Alan T. Remaley, Vipul Periwal, Jack A. Yanovski, Andrew P. Demidowich Tags: Original Research Source Type: research

Pharmacodynamic relationship between PCSK9, alirocumab, and LDL-C lowering in the ODYSSEY CHOICE I trial
The ODYSSEY CHOICE I study (NCT01926782) evaluated alirocumab 300 mg every 4 weeks (Q4W) in patients with hypercholesterolemia receiving maximally tolerated statin or no statin. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - July 25, 2020 Category: Lipidology Authors: Eli M. Roth, John J.P. Kastelein, Christopher P. Cannon, Michel Farnier, James M. McKenney, A. Thomas DiCioccio, Aur élie Brunet, Garen Manvelian, William J. Sasiela, Marie T. Baccara-Dinet, Jian Zhao, Jennifer G. Robinson Tags: Original Research Source Type: research

Successful treatment of a patient with mitochondrial myopathy with alirocumab
A 48-year-old man presented to out lipid clinic with statin intolerance and elevated serum creatine kinase levels, being affected by mitochondrial myopathy due to heteroplasmic mtDNA missense mutation in MTCO1 gene (m.7671T>A). He had just been treated with a coronary artery bypass 4 years before because of acute coronary syndrome, and he had consistently high levels of both low-density lipoprotein cholesterol and triglycerides.Dyslipidemia was successfully treated with alirocumab 75 mg subcutaneously every 2 weeks, ezetimibe 10 mg daily, 2 g daily of marine omega-3 fatty acids and 145 mg micronized fenofibrate every 2 ...
Source: Journal of Clinical Lipidology - July 23, 2020 Category: Lipidology Authors: Arrigo F.G. Cicero, Federica Fogacci, Marilisa Bove, Claudio Borghi Tags: Case Report Source Type: research

ZPR1 genotype predicts myocardial infarction in patients with familial hypercholesterolemia
The rs964184 variant in the ZPR1 gene has been associated with blood lipids and cardiovascular disease risk in the general population through genome-wide association study (GWAS), but its effect in patients with familial hypercholesterolemia (FH) has never been studied. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - July 23, 2020 Category: Lipidology Authors: Martine Paquette, Manon Fantino, Sophie Bernard, Alexis Baass Tags: Original Research Source Type: research

Failure of cosegregation between a rare STAP1 missense variant and hypercholesterolemia
Autosomal dominant familial hypercholesterolemia (FH) is characterized by elevated low-density lipoprotein cholesterol (LDL-C) levels and increased risk for atherosclerotic cardiovascular disease. While rare pathogenic variants in genes encoding the low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB), proprotein convertase subtilisin/kexin 9 (PCSK9) are found in more than 80% of molecularly defined FH patients, a few rare minor causative genes have been proposed, including the gene encoding signal transducing adaptor family member 1 (STAP1). (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - July 23, 2020 Category: Lipidology Authors: Reza Mohebi, Qinzhong Chen, Robert A. Hegele, Robert S. Rosenson Tags: Case Report Source Type: research

Successful pharmacological management of a child with compound heterozygous familial hypercholesterolemia and review of recent literature
We report on the decade long therapeutic journey of a 15-year old boy with SFH due to a severe compound heterozygous genotype. He presented at age 5 years with widespread xanthomas and LDL-C of 17.4 mmol/L. He was diagnosed with SFH, initially treated with colestyramine that was subsequently combined with simvastatin. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - July 14, 2020 Category: Lipidology Authors: Aravind Venkatesh Sreedharan, Pek Li Ting Sharon, Teng Hong Tan, Subramaniam Tavintharan, Fabian Yap Tags: Case Report Source Type: research

Viewing Atherosclerosis through a Crystal Lens: How the Evolving Structure of Cholesterol Crystals in Atherosclerotic Plaque Alters its Stability
Reducing the residual risk of cardiovascular events (CV) in patients with atherosclerosis continues to be a challenge. Thus, understanding how cholesterol spontaneously self assembles into metastable structures that evolve into flat plate cholesterol crystals (CCs) in atherosclerotic plaque, and why they fundamentally change the nature of the disease provides a paradigm for the development of additional therapies. Specifically, flat plate CCs that form within lysosomes of macrophages may become large enough to disrupt lysosomal membranes leading to the release of cathepsin B and CCs fragments directly into the cytosol. (So...
Source: Journal of Clinical Lipidology - July 10, 2020 Category: Lipidology Authors: Mark Nidorf, Aernoud Fiolet, George S. Abela Tags: Review Article Source Type: research

Authors ’ response to letter by Fogacci, Borghi, and Cicero, “Misinterpreting data in lipidology in the era of COVID-19”
Although we appreciate the comments from Drs Fogacci, Borghi, and Cicero on our publication “Hypolipidemia is associated with the severity of COVID-19”,1 we disagree on their opinions. Our data have been properly interpreted and our conclusions are supported by much emerging evidence from other studies.2–5 (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - July 8, 2020 Category: Lipidology Authors: Xiaoling Cao, Hui Wang, Wenbin Tan Tags: Letter to the Editor Source Type: research

Neuroprotective Associations of Apolipoproteins A-I and A-II with Neurofilament Levels in Early Multiple Sclerosis
The role of cholesterol homeostasis in neuroaxonal injury in multiple sclerosis (MS) is not known. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - July 8, 2020 Category: Lipidology Authors: Mason McComb, Maggie Krikheli, Tomas Uher, Richard W. Browne, Barbora Srpova, Johanna Oechtering, Aleksandra Maleska Maceski, Michaela Tyblova, Dejan Jakimovski, Deepa P. Ramasamy, Niels Bergsland, Jan Krasensky, Libuse Noskova, Lenka Fialova, Bianca Wein Tags: Original Research Source Type: research

Vasomotor Symptoms and Lipids/Lipoprotein Subclass Metrics in Midlife Women: Does Level of Endogenous Estradiol Matter?The SWAN HDL Ancillary Study
A greater frequency of vasomotor symptoms (VMS) has been associated with higher low-density lipoprotein cholesterol (LDL-C), but the association with high-density lipoprotein cholesterol (HDL-C) remains unclear. Endogenous estradiol (E2) levels are associated with both VMS and lipid levels, and thus, may confound such associations. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - July 8, 2020 Category: Lipidology Authors: Alexis Nasr, Karen A. Matthews, Maria M. Brooks, Daniel S. McConnell, Trevor J. Orchard, Jeffrey Billheimer, Daniel J. Rader, Samar R. El Khoudary Tags: Original Research Source Type: research

Misinterpreting data in lipidology in the era of COVID-19
(Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - July 8, 2020 Category: Lipidology Authors: Federica Fogacci, Claudio Borghi, Arrigo F.G. Cicero Tags: Letter to the Editor Source Type: research

Authors ’ response to letter by Fogacci, Borghi and Cicero, “Misinterpreting data in lipidology in the era of COVID-19”
(Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - July 8, 2020 Category: Lipidology Authors: Xiaoling Cao, Hui Wang, Wenbin Tan Tags: Letter to the Editor Source Type: research

Lipoprotein(a) Levels and Association with Myocardial Infarction and Stroke in a Nationally Representative Cross-Sectional US Cohort
Lipoprotein(a) (Lp(a)) has not been well-studied in a nationally representative US cohort. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - July 3, 2020 Category: Lipidology Authors: Eric J. Brandt, Arya Mani, Erica S. Spatz, Nihar Desai, Khurram Nasir Tags: Original Research Source Type: research

Are Statins Safe in Patients With COVID-19?
(Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - June 22, 2020 Category: Lipidology Authors: Dean G. Karalis Tags: Editorial Source Type: research

Low-density Lipoprotein Cholesterol Levels Among Individuals Experiencing Statin-Associated Symptoms: Data from the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
Guidelines recommend adults who discontinue statin therapy due to statin-associated symptoms be re-initiated. Low-density lipoprotein cholesterol (LDL-C) levels achieved after statin re-initiation are unknown. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - June 17, 2020 Category: Lipidology Authors: Rikki M. Tanner, Lisandro D. Colantonio, Meredith L. Kilgore, Matthew T. Mefford, Dayl T. Chachappan, Katherine E. Mues, Monika M. Safford, Robert S. Rosenson, Paul Muntner Tags: Original Research Source Type: research

Prevention of endothelial dysfunction and thrombotic events in COVID-19 patients with familial hypercholesterolemia
(Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - June 15, 2020 Category: Lipidology Authors: Alpo Vuorio, Petri T. Kovanen Tags: Letter to the Editor Source Type: research

A cautionary tale: Is this APOB whole-gene duplication actually pathogenic?
A 22 year-old woman presented with elevated LDL cholesterol and clinically suspected familial hypercholesterolemia (FH). Initial genetic analysis by Sanger sequencing found no causal variants in LDLR or other FH genes. More than a decade later, her 9 year-old daughter was also found to have elevated LDL cholesterol. Re-analysis using current genetic methodology detected a novel whole-gene duplication of APOB in both individuals, which was tentatively assumed to explain their elevated LDL cholesterol based mainly on biological plausibility. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - June 15, 2020 Category: Lipidology Authors: Julieta Lazarte, Amanda J. Berberich, Jian Wang, Robert A. Hegele Tags: Case Report Source Type: research

A Simplified Diagnosis Algorithm for Dysbetalipoproteinemia
Dysbetalipoproteinemia (DBL) is a disease of remnant lipoprotein accumulation caused by a defective apolipoprotein (apo) E and is associated with a considerable atherogenic burden. However, there exists confusion concerning the diagnosis of this disorder, and as a consequence, misdiagnosis is frequent. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - June 10, 2020 Category: Lipidology Authors: Martine Paquette, Sophie Bernard, David Blank, Guillaume Par é, Alexis Baass Tags: Original Research Source Type: research

Free fatty acids, cardiovascular disease, and mortality in the Multi-Ethnic Study of Atherosclerosis
Fasting free fatty acid (FFA) levels may be associated with cardiovascular disease (CVD) and mortality, but research among generally healthy adults, females, and racially/ethnically diverse populations is lacking. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - June 9, 2020 Category: Lipidology Authors: Sarah O. Nomura, Amy B. Karger, Natalie L. Weir, Daniel A. Duprez, Michael Y. Tsai Tags: Original Article Source Type: research

Free fatty acids, cardiovascular disease and mortality in the Multi-Ethnic Study of Atherosclerosis (MESA)
Fasting free fatty acid (FFA) levels may be associated with cardiovascular disease (CVD) and mortality, but research among generally healthy adults, females and racially/ethnically diverse populations is lacking. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - June 9, 2020 Category: Lipidology Authors: Sarah O. Nomura, Amy B. Karger, Natalie L. Weir, Daniel A. Duprez, Michael Y. Tsai Tags: Original Research Source Type: research

Fasting serum free glycerol concentration is a potential surrogate marker of visceral obesity and insulin sensitivity in middle-aged Japanese men
Triglyceride (TG) is a tri-ester composed of a glycerol and three fatty acids. Degradation of TG in adipose tissue is increased in the fasting state, but inhibited in the postprandial state. Although insulin suppresses adipose TG degradation, patients with insulin resistance have high concentrations of insulin and free glycerol (FG) in the fasting state. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - June 9, 2020 Category: Lipidology Authors: Satoshi Hirayama, Atsushi Hori, Miwa Isshiki, Akiko Hirayama, Tsuyoshi Ueno, Yoshifumi Tamura, Hideyoshi Kaga, Hirotaka Watada, Ryuzo Kawamori, Takashi Miida Tags: Original Research Source Type: research

Autosomal recessive hypercholesterolemia in a kindred of Syrian ancestry
Autosomal recessive hypercholesterolemia is a rare genetic disorder due to homozygosity or compound heterozygosity for mutations in the low-density lipoprotein receptor adapter protein 1 gene (LDLRAP1), resulting in elevated low-density lipoprotein cholesterol (LDL-C) levels, large xanthomas, and increased cardiovascular risk. Here, we describe a Danish family of Syrian ancestry carrying a frameshift mutation in LDLRAP1, previously only described in Sardinia and Sicily in Italy and in Spain. In 2 children homozygous for this mutation, we evaluate the effect of long-term lipid-lowering treatment with atorvastatin as monothe...
Source: Journal of Clinical Lipidology - June 8, 2020 Category: Lipidology Authors: Morten Hostrup Martinsen, Ib Christian Klausen, Anne Tybjaerg-Hansen, Berit Storgaard Hedegaard Source Type: research

Autosomal recessive hypercholesterolemia in a kindred of Syrian ancestry.
Autosomal recessive hypercholesterolemia (ARH) is a rare genetic disorder due to homozygosity or compound heterozygosity for mutations in the Low-Density Lipoprotein Receptor Adapter Protein 1 gene (LDLRAP1), resulting in elevated low-density lipoprotein cholesterol (LDL-C) levels, large xanthomas, and increased cardiovascular risk. Here we describe a Danish family of Syrian ancestry carrying a frameshift mutation in LDLRAP1, previously only described in Sardinia and Sicily in Italy, and in Spain. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - June 8, 2020 Category: Lipidology Authors: Morten Hostrup Martinsen, Ib Christian Klausen, Anne Tybjaerg-Hansen, Berit Storgaard Hedegaard Source Type: research

Low levels of cholesterol and the cholesterol type are not associated with depression: Results of a cross-sectional NHANES study
Reports suggest low levels of cholesterol are associated with depression. However, results have not been replicated, the direction of the associations among types of cholesterol levels is not consistent, there is large study heterogeneity, and many studies have small samples. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - June 6, 2020 Category: Lipidology Authors: M. Soledad Cepeda, David M. Kern, Clair Blacketer, Wayne C. Drevets Tags: Original Article Source Type: research

Low levels of cholesterol and cholesterol type are not associated with depression: Results of a cross-sectional NHANES study
Reports suggest low levels of cholesterol are associated with depression. However, results have not been replicated, the direction of the associations among types of cholesterol levels are not consistent, there is large study heterogeneity and many studies have small samples. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - June 6, 2020 Category: Lipidology Authors: M. Soledad Cepeda, David M. Kern, Clair Blacketer, Wayne C. Drevets Tags: Original Research Source Type: research

Genetic variants in SUSD2 are associated with the risk of ischemic heart disease
Genetic factors partly determine the risk for premature myocardial infarction (MI). (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - June 3, 2020 Category: Lipidology Authors: Caroline S. Bruikman, Nawar Dalila, Julian C. van Capelleveen, Jeffrey Kroon, Jorge Peter, Stefan R. Havik, Martine Willems, Laurens C. Huisman, Onno J. de Boer, G. Kees Hovingh, Anne Tybjaerg-Hansen, Geesje M. Dallinga-Thie Tags: Original Article Source Type: research

Genetic Variants in SUSD2 are Associated with Risk of Ischemic Heart Disease
Genetic factors partly determine the risk for premature myocardial infarction (MI). (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - June 3, 2020 Category: Lipidology Authors: Caroline S. Bruikman, Nawar Dalila, Julian C. van Capelleveen, Jeffrey Kroon, Jorge Peter, Stefan R. Havik, Martine Willems, Laurens C. Huisman, Onno J. de Boer, G. Kees Hovingh, Anne Tybjaerg-Hansen, Geesje M. Dallinga-Thie Tags: Original Research Source Type: research

High prevalence of plasma lipid abnormalities in human and canine Duchenne and Becker muscular dystrophies depict a new type of primary genetic dyslipidemia.
Duchenne and Becker muscular dystrophies (DMD/BMD) are allelic X-linked recessive muscle diseases caused by mutations in the DMD gene, with DMD being the more severe form. We have recently shown that increased plasma low-density lipoprotein-associated cholesterol (LDL-C) causes severe muscle wasting in the mdx mouse, a mild DMD model, which suggested that plasma lipids may play a critical role in DMD. We have also observed that loss of dystrophin in mice causes unexpected elevations in plasma lipoprotein levels. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 28, 2020 Category: Lipidology Authors: Zoe White, Chady H. Hakim, Marine Theret, N. Nora Yang, Fabio Rossi, Dan Cox, Gordon A. Francis, Volker Straub, Kathryn Selby, Constadina Panagiotopoulos, Dongsheng Duan, Pascal Bernatchez Tags: Original Research Source Type: research

Quantile-specific heritability of high-density lipoproteins with implications for precision medicine
We have previously shown that the effect of an HDL genetic risk score depends upon whether the phenotype (HDL-cholesterol) is high or low relative to its distribution (quantile-dependent expressivity). (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 28, 2020 Category: Lipidology Authors: Paul T. Williams Tags: Original Research Source Type: research

Statin use and fall-related hospitalizations among residents of long-term care facilities: A case-control study
Statins are associated with muscle-related adverse events, but few studies have investigated the association with fall-related hospitalizations among residents of long-term care facilities (LTCFs). (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 21, 2020 Category: Lipidology Authors: Kate N. Wang, J Simon Bell, Edwin CK. Tan, Julia FM. Gilmartin-Thomas, Michael J. Dooley, Jenni Ilom äki Tags: Original Research Source Type: research

The first Japanese cases of familial hypercholesterolemia due to a known pathogenic APOB gene variant, c.10580G > A: p.(Arg3527Gln)
We previously showed that patients without pathogenic variants in the LDLR and PCSK9 genes comprised approximately 40% of familial hypercholesterolemia (FH) cases. Objective: Our aim was to identify novel causative variants in Japanese FH patients. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 21, 2020 Category: Lipidology Authors: Mika Hori, Atsushi Takahashi, Cheol Son, Masatsune Ogura, Mariko Harada-Shiba Tags: Original Research Source Type: research

Statin use and fall-related hospitalizations among residents of long term care facilities: a case-control study
Statins are associated with muscle-related adverse events, but few studies have investigated the association with fall-related hospitalizations among residents of long-term care facilities (LTCFs). (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 21, 2020 Category: Lipidology Authors: Kate N. Wang, J Simon Bell, Edwin CK. Tan, Julia FM. Gilmartin-Thomas, Michael J. Dooley, Jenni Ilom äki Tags: Original Research Source Type: research

Gene –environment interaction between APOA5 c.553G > T and pregnancy in hypertriglyceridemia-induced acute pancreatitis
The etiology of hypertriglyceridemia (HTG) and, consequently, HTG-induced acute pancreatitis (HTG-AP), is complex. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 20, 2020 Category: Lipidology Authors: Na Pu, Qi Yang, Xiao-Lei Shi, Wei-Wei Chen, Xiao-Yao Li, Guo-Fu Zhang, Gang Li, Bai-Qiang Li, Lu Ke, Zhi-Hui Tong, David N. Cooper, Jian-Min Chen, Wei-Qin Li, Jie-Shou Li Tags: Original Article Source Type: research

Gene-environment interaction between APOA5 c.553G > T and pregnancy in hypertriglyceridemia-induced acute pancreatitis
The etiology of hypertriglyceridemia (HTG) and, consequently HTG-induced acute pancreatitis (HTG-AP), is complex. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 20, 2020 Category: Lipidology Authors: Na Pu, Qi Yang, Xiao-Lei Shi, Wei-Wei Chen, Xiao-Yao Li, Guo-Fu Zhang, Gang Li, Bai-Qiang Li, Lu Ke, Zhi-Hui Tong, David N. Cooper, Jian-Min Chen, Wei-Qin Li, Jie-Shou Li Tags: Original Research Source Type: research

Lipoprotein(a) concentration, genetic variants, apo(a) isoform size, and cellular cholesterol efflux in patients with elevated Lp(a) and coronary heart disease submitted or not to lipoprotein apheresis: An Italian case-control multicenter study on Lp(a)
Coronary artery disease (CAD) risk is greater with higher plasma lipoprotein(a)[Lp(a)] concentrations or smaller apoisoform size and putatively with increased cellular cholesterol loading capacity (CLC). The relationship between Lp(a) and CLC is not known. Information on Lp(a) polymorphisms in Italian patients is lacking. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 18, 2020 Category: Lipidology Authors: Claudia Stefanutti, Livia Pisciotta, Elda Favari, Serafina Di Giacomo, Federica Vacondio, Maria Grazia Zenti, Claudia Morozzi, Daniele Berretti, Dario Mesce, Marco Vitale, Andrea Pasta, Annalisa Ronca, Anna Garuti, Matteo Manfredini, Eduardo Angl és-Cano Tags: Original Article Source Type: research

Lipoprotien(a) concentration, genetic variants, apo(a) isoform size, and cellular cholesterol efflux in patients with elevated Lp(a) and coronary heart disease submitted or not to lipoprotein apheresis: An Italian case-control multicenter study on Lp(a)
Coronary artery disease (CAD) risk is greater with higher plasma lipoprotein(a)[Lp(a)] concentrations or smaller apoisoform size and putatively with increased cellular cholesterol loading capacity (CLC). The relationship between Lp(a) and CLC is not known. Information on Lp(a) polymorphisms in Italian patients is lacking. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 18, 2020 Category: Lipidology Authors: C. Stefanutti, L. Pisciotta, E. Favari, S. Di Giacomo, F. Vacondio, M.G. Zenti, C. Morozzi, D. Berretti, D. Mesce, M. Vitale, A. Pasta, A. Ronca, A. Garuti, M. Manfredini, E. Angl és-Cano, S.M. Marcovina, G.F. Watts, the Multidisciplinary International G Tags: Original Article Source Type: research

Lp(a) concentration, genetic variants, apo(a) isoform size and cellular cholesterol efflux in subjects with elevated Lp(a) and coronary heart disease submitted or not to lipoprotein apheresis. The Italian case-control multicentre study on Lp(a)
Coronary artery disease(CAD) risk is greater with higher plasma lipoprotein(a)[Lp(a)] concentrations or smaller apoisoform size and putatively with increased cellular cholesterol loading capacity (CLC). The relationship between Lp(a) and CLC is not known. Information on Lp(a) polymorphisms in Italian patients is lacking. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 18, 2020 Category: Lipidology Authors: C. Stefanutti, L. Pisciotta, E. Favari, S. Di Giacomo, F. Vacondio, M.G. Zenti, C. Morozzi, D. Berretti, D. Mesce, M. Vitale, A. Pasta, A. Ronca, A. Garuti, M. Manfredini, E. Angl és-Cano, S.M. Marcovina, G.F. Watts, the Multidisciplinary International G Tags: Original Research Source Type: research

When a “normal” cholesterol level is not normal: Exposing an unusual presentation of familial hypercholesterolemia
▪▪▪. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 12, 2020 Category: Lipidology Authors: Carl E. Orringer, Jelani K. Grant Tags: Case Study Source Type: research

When A ‘Normal’ Cholesterol Level Is Not Normal: Exposing an Unusual Presentation of Familial Hypercholesterolemia
(Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 12, 2020 Category: Lipidology Authors: Carl E. Orringer, Jelani K. Grant Source Type: research

Genetic Testing in Dyslipidemia: A Scientific Statement from the National Lipid Association
The genetic basis for more than two dozen monogenic dyslipidemias has largely been defined. Genetic technologies, such as DNA sequencing, can detect both rare and common DNA variants underlying dyslipidemias and these methods are increasingly available. Although patients with extreme abnormalities in low-density lipoprotein cholesterol (LDL-C), triglycerides or high-density lipoprotein cholesterol (HDL-C) may be considered for genetic testing, it is only in a minority of patients that the results will alter treatment or outcomes. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 6, 2020 Category: Lipidology Authors: Emily E. Brown, Amy C. Sturm, Marina Cuchel, Lynne T. Braun, P. Barton Duell, James A. Underberg, Terry A. Jacobson, Robert A. Hegele Tags: Original Research Source Type: research

Author's reply to: Arterial stiffness improvement after adding on PCSK9 inhibitors in patients with familial hypercholesterolemia, a letter from Papaioannou and colleagues
We are very grateful to Papaioannou and his team for opening the interesting question about the potential link between lipid factors control, vascular and endothelial damage, pulse wave velocity (PWV), and cardiovascular (CV) risk.1 Low-density lipoprotein cholesterol (LDL-C) and blood pressure are indeed two of the most important CV risk factors, and low variability of LDL-C and systolic blood pressure are associated with a significant reduction of CV events.2 As they already underlined, we found that by reducing LDL-C with optimal lipid-lowering therapy, adding on ezetimibe and eventually PCSK9 inhibitor to highly effect...
Source: Journal of Clinical Lipidology - May 5, 2020 Category: Lipidology Authors: Giuseppe Mandraffino, Roberto Scicali, Giovanni Squadrito Tags: Letter to the Editor Source Type: research

The Association between Triglycerides and Incident Cardiovascular Disease: What Is “Optimal”?
Elevated triglycerides (TG) are associated with increased risk of cardiovascular disease (CVD), but the best way to both measure TG and assess TG-related risk remains unknown. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 5, 2020 Category: Lipidology Authors: Tsion Aberra, Eric D. Peterson, Neha J. Pagidipati, Hillary Mulder, Daniel M. Wojdyla, Sephy Philip, Craig Granowitz, Ann Marie Navar Tags: Original Research Source Type: research

[Author ’s Reply to: Arterial stiffness improvement after adding on PCSK9 inhibitors in patients with familial hypercholesterolemia, a letter from Papaioannou and coll.]
(Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 5, 2020 Category: Lipidology Authors: Giuseppe Mandraffino, Roberto Scicali, Giovanni Squadrito Tags: Letter to the Editor Source Type: research

From the editor: Plagues and the ancient legacy of Epimenides
Infectious disease epidemics used to happen frequently, a woeful recurrent theme of life on this planet. Now they are uncommon at least in the developed world. My grandparents experienced the influenza pandemic of 1918, but my parents, born shortly thereafter and now departed, never experienced what we are going through today. The lipidology community is adapting, mostly learning to do telemedicine from home. Some are providing front-line service in emergency departments, hospital wards, intensive care units, testing stations, and research studies. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 1, 2020 Category: Lipidology Authors: John R. Guyton Tags: Foreword Source Type: research

News from the NLA
The National Lipid Association has released the much-anticipated Edition V of the Self-Assessment Program (NLA-SAP). The NLA-SAP has been updated to provide a critical assessment of your knowledge and to guide you in the selection of additional training courses as well as prepare you for certification in clinical lipidology. This program works to objectively validate and enhance your clinical knowledge of the core curriculum in clinical lipidology as well as challenge your problem-solving skills in the diagnosis and management of patients with dyslipidemia. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 1, 2020 Category: Lipidology Source Type: research

JCL roundtable: Healthy ethnic diets
Epidemiology has long suggested that diet plays a major role in determining risk for atherosclerotic cardiovascular disease. A small number of important randomized controlled trials support this contention. We have to recognize that dietary patterns also constitute a large part of ethnic identity. In our increasingly connected world of international mobility and influence, lipidologists face new challenges in counseling patients with diverse nutritional preferences. In this JCL roundtable, we discuss Hispanic, South Asian, and Mediterranean dietary patterns and their association with atherosclerotic risk. (Source: Journal ...
Source: Journal of Clinical Lipidology - May 1, 2020 Category: Lipidology Authors: Mary Felando, Heather Rasmussen, Wahida Karmally, John R. Guyton Tags: Clinical Lipidology Roundtable Discussion Source Type: research

Editorial Board
(Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 1, 2020 Category: Lipidology Source Type: research

Table of Contents
(Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 1, 2020 Category: Lipidology Source Type: research

Hypolipidemia is associated with the severity of COVID-19
Many patients with coronavirus disease 2019 (COVID-19) suffer multiple organ dysfunctions. However, whether patients develop dyslipidemia is unknown. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - April 30, 2020 Category: Lipidology Authors: Xiuqi Wei, Wenjuan Zeng, Jingyu Su, Huimin Wan, Xinqin Yu, Xiaoling Cao, Wenbin Tan, Hui Wang Tags: Original Research Source Type: research