Association of Cumulative Low-density Lipoprotein Cholesterol Exposure with Vascular Function
Atherosclerosis begins with endothelial dysfunction as the initial step, followed by vascular smooth muscle dysfunction in the advanced stage. Plaque progression occurs asymptomatically, finally leading to cardiovascular events.1, 2 Measurements of vascular function including measurements of flow-mediated vasodilation (FMD) in the brachial artery, nitroglycerine-induced vasodilation (NID) in the brachial artery and intima-media thickness (IMT) in the common carotid artery (CCA) are the most popular tools for the assessment of atherosclerosis progression. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - December 25, 2023 Category: Lipidology Authors: Takayuki Yamaji, Farina Mohamad Yusoff, Shinji Kishimoto, Masato Kajikawa, Kenichi Yoshimura, Yukiko Nakano, Chikara Goto, Takahiro Harada, Aya Mizobuchi, Shunsuke Tanigawa, Tatsuya Maruhashi, Yukihito Higashi Tags: Original Research Source Type: research
Modern approaches to the management of homozygous familial hypercholesterolemia in the Middle East and North Africa
Homozygous familial hypercholesterolemia (HoFH) is a rare, inherited disorder of lipid metabolism in which mutations in two genes or alleles in the low-density lipoprotein receptor (LDL-R) pathway result in extremely high levels of circulating LDL cholesterol (LDL-C).1 Untreated LDL-C levels>10mmol/L are often indicative of HoFH and warrant evaluation.1 HoFH is the rare, homozygous form of FH. FH is the most common monogenic disorder in man.2 HoFH occurs when both parents carry FH mutations that combine in the child either as a two homozygous alleles (termed monogenic, biallelic semi-dominant hypercholesterolemia) or as a ...
Source: Journal of Clinical Lipidology - December 14, 2023 Category: Lipidology Authors: Dr Abdullah Al-Ashwal, Dr Mohammed Al Dubayee, Dr Afaf Alsagheir, Dr Mutaz Al-Sabah, Dr Ahmed Al-Sarraf, Dr Zuhier Awan, Dr Tawfeg Ben-Omran, Dr Saif Al-Yaarubi, Dr Angham Almutair, Dr Abdelhadi Habeb, Dr Faouzi Maatouk, Manal Alshareef, Dr Naji Kholaif, Tags: Review Article Source Type: research
No benefit of vitamin D supplementation on muscle function and Health-Related Quality of Life in primary cardiovascular prevention patients with statin-associated muscle symptoms: a randomized controlled trial
Generally well tolerated, statin use is nevertheless associated with various side effects, notably statin associated muscular symptoms (SAMS). The vast majority of SAMS are mild muscle symptoms. They present typically as increased sensitivity to palpation, weakness, fatigue, aches, and/or cramps, and are almost always reported in large muscle groups (especially pectorals, quadriceps, biceps, and deltoids)1,2. These symptoms usually appear without elevated levels of circulating markers of muscle damage, such as creatine kinase (CK) or myoglobin (Mb), although in rare cases myopathy and rhabdomyolysis are observed3. (Source:...
Source: Journal of Clinical Lipidology - December 14, 2023 Category: Lipidology Authors: Paul Peyrel, Pascale Mauri ège, Jérôme Frenette, Nathalie Laflamme, Karine Greffard, Sébastien S. Dufresne, Claire Huth, Jean Bergeron, Denis R. Joanisse Tags: Original Research Source Type: research
JCL Roundtable: Evolution of Preventive Cardiology and Clinical Lipidology
It's a privilege to discuss preventive cardiology with 3 of the foremost U.S. leaders in this growing subspecialty. Preventive cardiology is the practice of primordial, primary, and secondary prevention of cardiovascular disease. It employs an integrated team of clinicians committed to preventing all forms of cardiovascular disease, including ischemic heart disease, heart failure, atrial fibrillation, and other conditions. Thus, contemporary preventive cardiology extends management beyond dyslipidemic risk reduction and now commonly includes treatment of hypertension, diabetes and other related cardiometabolic disorders, n...
Source: Journal of Clinical Lipidology - December 14, 2023 Category: Lipidology Authors: Martha Gulati, Erin D. Michos, William E. Boden, John R. Guyton Source Type: research
Hepatic Fat Changes with Antisense Oligonucleotide Therapy Targeting ANGPTL3
Angiopoietin-like protein 3 (ANGPTL3) is a key regulator of the metabolism of triglyceride-rich lipoproteins.1 Secreted by the liver, ANGPTL3 inhibits lipoprotein lipase and endothelial lipase, resulting in increased plasma triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C).1 Loss-of-function variants in the ANGPTL3 gene are associated with decreased triglycerides, LDL-C, and HDL-C, and have been linked to lower risk of coronary artery disease. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - December 9, 2023 Category: Lipidology Authors: Andre Zimerman, Stephen D. Wiviott, Jeong-Gun Park, Sabina A. Murphy, Xinhui Ran, Candace R. Bramson, Madelyn Curto, Vesper Ramos, Alexandra Jevne, Julia F. Kuder, Subodh Verma, Wojtek Wojakowski, Steven G. Terra, Marc S. Sabatine, Brian A. Bergmark, Nich Tags: Original Research Source Type: research
Universal Lipid Screening in Adolescents to Identify Familial Hypercholesterolemia in a Large Healthcare System
Familial Hypercholesterolemia (FH) is a common treatable monogenic disorder found throughout the world with an estimated prevalence of 1 in 300 people in the largest analysis to date, though various regional population estimates range from approximately 1 in 100 to 1 in 500. 1 Untreated FH increases mortality 25-fold by age 60-years 2 by causing nearly 20% of myocardial infarctions prior to the age of 45 3 and conveying a 50% risk for males (historically higher than females) for a myocardial infarction before age 50-years. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - December 7, 2023 Category: Lipidology Authors: Alan B Cortez, Miriam Salvador, Qiaowu Li, Audrey Briscoe Tags: Original Research Source Type: research
A Case Report Of Tangier Disease Presents With Acute Sensorimotor Polyneuropathy And Its Treatment Approach
Tangier disease (TD) is a very rare disorder, inherited autosomal recessively due to mutations in encoding ATP-binding cassette transporter 1 (ABCA1) gene on chromosome 9q311,2,3. In lipid metabolism, apolipoprotein (Apo) A-1 takes cholesterol esters from peripheral tissues via ABCA1 receptors and then transfers them to HDL-3 with the help of lecithin-cholesterol acyltransferase1,2,3. HDL-3 density range is predominantly comprised of particles containing apoA-1 and apoA-2 (small HDL, very small HDL). (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - December 1, 2023 Category: Lipidology Authors: Saniye Karabudak, Vildan G üzel, Beril Güler, Bülent Uyanık, Azize Esra Gürsoy Tags: Case Study Source Type: research
Fatty acid analysis in serum of patients with elevated lipoprotein(a) and cardiovascular disease undergoing lipoprotein apheresis
Lipoprotein(a) (Lp(a)) consists of LDL-like particle covalently banded with apolipoprotein (a) [apo(a)]. Apo(a) is encoded by LPA gene localized on chromosome 6q27 and consists of loop-like structures called cringles. KIV-2 copy number variation (from 1 to 40 repeat sequences) polymorphism is the most important predictor of variations in Lp(a) concentration. Small isoforms (≤22 KIV repeats) are related to 4 to 5-fold higher Lp(a) concentrations than large isoforms (>22 KIV). Roeseler at al. reported that 95% patients with CVD undergoing lipoprotein apheresis (LA) therapy expressed at least one small apo(a) isoform. (So...
Source: Journal of Clinical Lipidology - November 27, 2023 Category: Lipidology Authors: Agnieszka Mickiewicz, Joanna Marl ęga-Linert, Monika Czapiewska, Marta Marcinkowska, Aleksandra Krzesińska, Agnieszka Kuchta, Marcin Fijałkowski, Marcin Gruchała, Adriana Mika Tags: Original Research Source Type: research
Habitual fish oil supplementation, genetic susceptibility of kidney stones and the risk of new-onset kidney stones
Kidney stones are a common, costly, and painful disease, affecting about 10% of adults worldwide, with the prevalence and incidence still increasing globally1, 2. Kidney stones significantly increase the risk of metabolic syndrome, cardiovascular disease and kidney failure, resulting in a huge disease burden3-5. Recent evidence showed that inflammation6 and hyperlipidemia7,8 play an important role in the pathogenesis of kidney stones. Therefore, anti-inflammatory and lipid-lowering treatments or supplements may have potential benefits for primary prevention of kidney stones. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - November 26, 2023 Category: Lipidology Authors: Xiaoqin Gan, Mengyi Liu, Panpan He, Ziliang Ye, Hao Xiang, Chun Zhou, Sisi Yang, Yanjun Zhang, Yuanyuan Zhang, Yu Huang, Xianhui Qin Tags: Original Research Source Type: research
Lipoprotein(a) levels and carotid intima-media thickness in children: A 20-year follow-up study
Elevated lipoprotein(a) [Lp(a)] levels are associated with an increased risk of cardiovascular disease (CVD)1, 2. With a reported population prevalence of approximately 20%, elevated Lp(a) (>50 mg/dL, corresponding to ≈120 nmol/L) is a prevalent risk factor3. Lp(a) levels are mainly genetically determined and if elevated, individuals are exposed to a high Lp(a)-burden from early in childhood onwards4. Results of a recent follow-up study in children with familial hypercholesterolemia (FH) showed that Lp(a) level s contributed significantly to arterial wall thickening, as measured by carotid intima-media thickness (cIMT), ...
Source: Journal of Clinical Lipidology - November 26, 2023 Category: Lipidology Authors: L.M. de Boer, B.A. Hutten, S. Tsimikas, C. Yeang, A.H. Zwinderman, J. Kroon, A. Revers, J.J.P. Kastelein, A. Wiegman Tags: Brief Communication Source Type: research
Differential Impacts of Admission LDL-Cholesterol on Early Vascular Outcomes by Ischemic Stroke Subtypes
The etiology of ischemic stroke is heterogeneous and can be categorized into five subtypes based on potential mechanisms: large artery atherosclerosis (LAA), cardioembolism (CE), small vessel occlusion (SVO), other determined etiology, and undetermined etiology.1 Understanding these subtypes is essential for tailoring stroke treatment and prevention strategies to address the specific underlying causes. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - November 26, 2023 Category: Lipidology Authors: Joon-Tae Kim, Ji Sung Lee, Hyunsoo Kim, Beom Joon Kim, Jihoon Kang, Keon-Joo Lee, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Tai Hwan Park, Kyung Bok Lee, Jun Lee, Keun-Sik Hong, Yong-Jin Cho, Hong-Kyun Park, Byung-C Tags: Original Research Source Type: research
Genetic risk score in patients with the APOE2/E2 genotype as a predictor of familial dysbetalipoproteinemia
Cardiovascular diseases (CVDs), mainly atherosclerotic diseases (ASCVDs), remain the leading cause of premature morbidity and mortality worldwide. In the Czech Republic, they account for 45% of total standardized mortality.1 Among other factors, such as smoking or obesity, different types of dyslipidemias (DLPs) play a pivotal role in ASCVD manifestation. The vast majority of DLPs have a significant genetic background, with many polymorphisms individually playing a relatively small but highly important role in concert. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - November 23, 2023 Category: Lipidology Authors: Martin Satny, Veronika Todorovova, Tereza Altschmiedova, Jaroslav A. Hubacek, Lucie Dlouha, Vera Lanska, Vladimir Soska, Ondrej Kyselak, Tomas Freiberger, Martin bobak, Michal Vrablik Tags: Original Research Source Type: research
Effectiveness of the triglyceride-glucose index and triglyceride-glucose-related indices in predicting cardiovascular disease in middle-aged and older adults: A prospective cohort study
Globally, there has been an increase in cardiovascular disease (CVD) owing to a shift in social structures and an increase in the aging population.1 In the United States of America, coronary artery disease (CAD) caused the death of 382,820 individuals in 2020, making it one of the primary causes of CVD-related deaths.2 In addition, 7.2% of adults aged 20 years (approximately 20.1 million individuals) had CAD. In the same year, nearly two out of 10 deaths from CAD occurred in individuals under 65 years of age. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - November 18, 2023 Category: Lipidology Authors: Hye-Min Park, Taehwa Han, Seok-Jae Heo, Yu-Jin Kwon Tags: Original Research Source Type: research
Advancements in Non-Invasive Imaging of Atherosclerosis: Future Perspectives
Atherosclerosis is a chronic inflammatory disease, characterized by the buildup of plaques within the arterial walls, causing cardiovascular diseases (ischemic heart disease, cerebrovascular disease and peripheral arterial disease) that remain the leading cause of morbidity and mortality worldwide. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - November 18, 2023 Category: Lipidology Authors: Joana Guimar ães, José de Almeida, Paulo Lázaro Mendes, Maria João Ferreira, Lino Gonçalves Tags: Review Article Source Type: research
Comparison of Virtual vs Face-to-face Medical Nutrition Therapy in Patients with Hyperlipidemia
Cardiovascular disease (CVD) is the leading cause of death in the United States,1 and the greatest contributor is poor nutrition.2 There is a well-established association between hyperlipidemia (HLD) and the development of CVD. Numerous societies including the American College of Cardiology, American Heart Association, and National Lipid Association recommend lifestyle intervention as an effective first step in the treatment of lipid disorders.3,4 Registered dietitian nutritionists (RDNs) have a critical role in helping patients implement lifestyle changes through medical nutrition therapy (MNT). (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - November 16, 2023 Category: Lipidology Authors: Shannon Zoulek, Jackson Shriver, Navkiranjot Kaur, Beverly Kuznicki, Eric J. Brandt Tags: Brief Communication Source Type: research
