Association of Cumulative Low-density Lipoprotein Cholesterol Exposure with Vascular Function

Atherosclerosis begins with endothelial dysfunction as the initial step, followed by vascular smooth muscle dysfunction in the advanced stage. Plaque progression occurs asymptomatically, finally leading to cardiovascular events.1, 2 Measurements of vascular function including measurements of flow-mediated vasodilation (FMD) in the brachial artery, nitroglycerine-induced vasodilation (NID) in the brachial artery and intima-media thickness (IMT) in the common carotid artery (CCA) are the most popular tools for the assessment of atherosclerosis progression.

Source: Journal of Clinical Lipidology - December 25, 2023 Category: Lipidology Authors: Takayuki Yamaji, Farina Mohamad Yusoff, Shinji Kishimoto, Masato Kajikawa, Kenichi Yoshimura, Yukiko Nakano, Chikara Goto, Takahiro Harada, Aya Mizobuchi, Shunsuke Tanigawa, Tatsuya Maruhashi, Yukihito Higashi Tags: Original Research Source Type: research