Hepatic Fat Changes with Antisense Oligonucleotide Therapy Targeting ANGPTL3

Angiopoietin-like protein 3 (ANGPTL3) is a key regulator of the metabolism of triglyceride-rich lipoproteins.1 Secreted by the liver, ANGPTL3 inhibits lipoprotein lipase and endothelial lipase, resulting in increased plasma triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C).1 Loss-of-function variants in the ANGPTL3 gene are associated with decreased triglycerides, LDL-C, and HDL-C, and have been linked to lower risk of coronary artery disease.

Source: Journal of Clinical Lipidology - December 9, 2023 Category: Lipidology Authors: Andre Zimerman, Stephen D. Wiviott, Jeong-Gun Park, Sabina A. Murphy, Xinhui Ran, Candace R. Bramson, Madelyn Curto, Vesper Ramos, Alexandra Jevne, Julia F. Kuder, Subodh Verma, Wojtek Wojakowski, Steven G. Terra, Marc S. Sabatine, Brian A. Bergmark, Nich Tags: Original Research Source Type: research