Ginseng polysaccharide components attenuate obesity and liver lipid accumulation by regulating fecal microbiota and hepatic lysine degradation
In this study, we found that PGP inhibited the high-fat diet (HFD)-induced weight gain, fat ratio and fat tissue weight after 8-week administration. Serum and liver lipid analysis showed that PGP decreased the levels of triglyceride and total cholesterol, which was mediated by the inhibition of key genes for fatty acid and cholesterol metabolisms. Metabolomics studies showed that the inhibitory effect of PGP on liver lipid accumulation was significantly correlated with its regulation of citric acid cycle and lysine degradation. PGP regulated the expression of genes related to lysine degradation in both liver tissue and hep...
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Qing Liu Zepeng Zhang Peng Ji Jiaqi Liu Boxue Chen E Mingyao Hongyu Qi Tong Hou Qingxia Huang Lu Ding Chen Guo Daqing Zhao Wenzhi Yang Zeyu Wang Xiangyan Li Source Type: research
Uncovering the Role of Anmeidan against Atherosclerosis from Integrated Network Pharmacology and Pharmacological Experiments
CONCLUSIONS: This study confirmed that AMD could treat AS by regulating lipid metabolism and preliminarily explored the related mechanism. These findings provide new ideas for the treatment of AS with TCM.PMID:38676497 | DOI:10.2174/0113862073281925240417062009 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Yuting Zheng Jianxiang Wang Chengcheng Pan Jihong Song Xingyue Li Wenjing Ta Wen Lu Source Type: research
Ultrasonic-assisted extraction of polysaccharide from Paeoniae Radix alba: Extraction optimization, structural characterization and antioxidant mechanism in vitro
Int J Biol Macromol. 2024 Apr 25:131816. doi: 10.1016/j.ijbiomac.2024.131816. Online ahead of print.ABSTRACTPaeoniae Radix alba is used in Traditional Chinese Medicine for the treatment of gastrointestinal disorders, immunomodulatory, cancer, and other diseases. In the current study, the yield of Paeoniae Radix alba polysaccharide (PRP) was significantly increased with optimal ultrasound-assisted extraction compared to hot water extraction. Further, an acidic polysaccharide (PRP-AP) was isolated from PRP after chromatographic separation and was characterized as a typical pectic polysaccharide with side chains of arabinogal...
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Chao-Wen Zhang Yuan-Feng Zou Yun Zou Xiao-Ping JiZe Cen-Yu Li Yu-Ping Fu Chao Huang Li-Xia Li Zhong-Qiong Yin Fa-Ming Wu Frode Rise Kari Tvete Inngjerdingen Sha-Qiu Zhang Xing-Hong Zhao Xu Song Xun Zhou Gang Ye Meng-Liang Tian Source Type: research
Per- and polyfluoroalkyl substances induce lipid metabolic impairment in fish: Integration on field investigation and laboratory study
This study innovatively explored the adverse effects of PFOS and F-53B on lipid metabolism and their mechanisms at field and laboratory levels, highlighting concerns regarding PFASs health risks.PMID:38677088 | DOI:10.1016/j.envint.2024.108687 (Source: Environment International)
Source: Environment International - April 27, 2024 Category: Environmental Health Authors: Qiyu Wang Xueyan Gu Limin Mo Nannan Wan Liu Wu Shuai Liu Miao Zhang Mingqi Li Xi Liu Yu Liu Source Type: research
Examination of eating competence in a geo-diverse sample with metabolic syndrome
Appetite. 2024 Apr 25:107373. doi: 10.1016/j.appet.2024.107373. Online ahead of print.ABSTRACTEating competence (EatC) is an intra-individual approach to eating attitudes and behaviors associated with greater well-being. EatC research has not included persons with confirmed metabolic syndrome (MetS). Therefore, EatC of persons with MetS was explored to identify unique associations and inform implementation of MetS lifestyle interventions using baseline data from a multisite, randomized trial of a 2-year lifestyle intervention with MetS. EatC, measured with the Satter Eating Competence Inventory 2.0 (ecSI 2.0™), was exami...
Source: Appetite - April 27, 2024 Category: Nutrition Authors: Barbara Lohse Bong Nguyen Betty M Drees Lisa Bailey-Davis Kevin S Masters Jacinda Nicklas Bryce Daniels Elizabeth H Ruder Nicole Trabold Source Type: research
LXR Agonist T0901317's Hepatic Impact Overrules Its Atheroprotective Action in Macrophages, Driving Early Atherogenesis in Chow-Diet-Fed Male Apolipoprotein E Knockout Mice
In conclusion, these findings highlight that the pro-atherogenic hepatic effects of LXR agonism are dominant over the anti-atherogenic effects in macrophages in determining the overall atherosclerosis outcome under low-fat diet feeding conditions. A low-fat diet experimental setting, as compared to the commonly used high-fat-diet-based preclinical setup, thus appears more sensitive in uncovering the potential relevance of the off-target liver effects of novel anti-atherogenic therapeutic approaches that target macrophage LXR.PMID:38672446 | DOI:10.3390/biom14040429 (Source: Atherosclerosis)
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Menno Hoekstra Laura M de Jong Rick van der Geest Lidewij R de Leeuw Rani Krisnamurthi Janine J Geerling Miranda Van Eck Source Type: research
Association between Statin Use and Chemotherapy-Induced Cardiotoxicity: A Meta-Analysis
Conclusion: Among patients of CIC, statin use has shown cardioprotective benefits by improving left ventricular function and reducing the risk of heart failure.PMID:38674227 | DOI:10.3390/medicina60040580 (Source: Cancer Control)
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Vikash Jaiswal Song Peng Ang Novonil Deb Muhammad Hanif Nitya Batra Sai Gautham Kanagala Nikhil Vojjala Kripa Rajak Poulami Roy Medha Sharath Madeeha Subhan Waleed Zarghoona Wajid Jishanth Mattumpuram Source Type: research
Correlations between preoperative statin treatment with short- and long-term survival following colorectal cancer surgery: a propensity score-matched national cohort study
ConclusionAlthough a subgroup of patients with a preoperative exposure time of 90 days showed statistically significant better overall survival, we found no statistically significant association between statin exposure 1 year before colorectal cancer surgery and overall survival. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 27, 2024 Category: Gastroenterology Source Type: research
A nonlinear relationship between the triglycerides to high-density lipoprotein cholesterol ratio and stroke risk: an analysis based on data from the China Health and Retirement Longitudinal Study
The connection between triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio and stroke risk is controversial. Our goal was to explore this relationship in individuals aged 45 and older enroll... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - April 27, 2024 Category: Endocrinology Authors: Shike Zhang, Changchun Cao, Yong Han, Haofei Hu and Xiaodan Zheng Tags: Research Source Type: research
Associations between non-insulin-based insulin resistance indices and heart failure prevalence in overweight/obesity adults without diabetes mellitus: evidence from the NHANES 2001 –2018
The triglyceride glucose (TyG) index and triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio are recognized as simple non-insulin-based insulin resistance indices. Our study aimed to explore ... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 27, 2024 Category: Lipidology Authors: Di-yu Cui, Chao Zhang, Yi Chen, Gang-zhen Qian, Wan-xiang Zheng, Zhi-hui Zhang, Yu Zhang and Ping Zhu Tags: Research Source Type: research
Statin Therapy and Cardiovascular Protection in Type 2 Diabetes: The Role of Baseline LDL-Cholesterol Levels: A Systematic Review and Meta-analysis of Observational Studies
This study aimed to determine the association of statin use in T2D patients with major adverse cardiovascular events (MACE) and all-cause mortality and whether this association differs by baseline LDL-C levels. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 27, 2024 Category: Nutrition Authors: Negin Soroush, Mitra Nekouei Shahraki, Soroush Mohammadi Jouabadi, Masoud Amiri, Elif Aribas, Bruno H. Stricker, Fariba Ahmadizar Source Type: research
Association of cardiac biomarkers with long-term cardiovascular events in a community cohort
DISCUSSION: Ceramide score and NT proBNP improve the prediction of MACE and stroke/MI in a community primary prevention cohort.PMID:38666319 | DOI:10.1080/1354750X.2024.2335245 (Source: Biomarkers)
Source: Biomarkers - April 26, 2024 Category: Research Authors: Robert A Churchill Benjamin R Gochanour Christopher G Scott Vlad C Vasile Richard J Rodeheffer Jeffrey W Meeusen Allan S Jaffe Source Type: research
Prevalence of risk factors for development of cardiovascular diseases in urban and rural areas of Eastern Croatia: a cross-sectional study
CONCLUSIONS: In the examined sample, the prevalence of cardiovascular risk factors is generally high. Participants from rural areas are significantly more susceptible to cardiovascular risk factors than participants from urban areas.PMID:38669153 | DOI:10.21101/cejph.a7709 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Mirta Klapec-Basar Tanja Kova č Renata Apati ć Željko Mudri Tin Basar Stjepan Juri ć Rudika Gmajni ć Robert Lovri ć Source Type: research
Association of cardiac biomarkers with long-term cardiovascular events in a community cohort
DISCUSSION: Ceramide score and NT proBNP improve the prediction of MACE and stroke/MI in a community primary prevention cohort.PMID:38666319 | DOI:10.1080/1354750X.2024.2335245 (Source: Biomarkers)
Source: Biomarkers - April 26, 2024 Category: Research Authors: Robert A Churchill Benjamin R Gochanour Christopher G Scott Vlad C Vasile Richard J Rodeheffer Jeffrey W Meeusen Allan S Jaffe Source Type: research
Prevalence of risk factors for development of cardiovascular diseases in urban and rural areas of Eastern Croatia: a cross-sectional study
CONCLUSIONS: In the examined sample, the prevalence of cardiovascular risk factors is generally high. Participants from rural areas are significantly more susceptible to cardiovascular risk factors than participants from urban areas.PMID:38669153 | DOI:10.21101/cejph.a7709 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Mirta Klapec-Basar Tanja Kova č Renata Apati ć Željko Mudri Tin Basar Stjepan Juri ć Rudika Gmajni ć Robert Lovri ć Source Type: research
