Relationship between changes in blood glucose, glycosylated hemoglobin [HbA1c], cholesterol, and triglyceride and changes in hepatic enzymes
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):23-28. doi: 10.14715/cmb/2024.70.4.4.ABSTRACTThe main risk factors for non-alcoholic fatty liver disease (NAFLD) are strongly associated with obesity, diabetes, hyperlipidemia, and metabolic syndrome. The best clinical evaluation of the liver is done through studying changes in liver enzymes' activity, especially alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase. Therefore, this study aimed to investigate the relationship between changes in factors such as blood glucose, cholesterol, glycosylated hemoglobin, and triglyceride and changes in hepat...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Mahboobeh Talebi Mehrdar Wei Lu Adel Rahanjam Source Type: research
Awareness of having hypertension, diabetes and dyslipidaemia among US adults: The 2011-2018 NHANES data
CONCLUSIONS: Large proportions of US adults with hypertension, dyslipidaemia and diabetes are not aware of having the conditions. Interventions targeting groups at higher risk of being unaware of these conditions are needed.PMID:38679806 | DOI:10.1177/14034948241247612 (Source: Scandinavian Journal of Public Health)
Source: Scandinavian Journal of Public Health - April 28, 2024 Category: International Medicine & Public Health Authors: Kien G To Corneel Vandelanotte Anh N V Huynh Stephanie Schoeppe Stephanie Alley Aamir Raoof Memon Nhung T Q Nguyen Quyen G To Source Type: research
Sesamin ameliorates nonalcoholic hepatic steatosis by inhibiting CD36-mediated hepatocyte lipid accumulation in vitro and in vivo
In this study, we observed the anti-hepatic steatosis effects of Ses in palmitate/oleate (PA/OA)-incubated primary mouse hepatocytes, AML12 hepatocytes, and HepG2 cells, as well as in high-fat, high-cholesterol diet-induced NASH mice. RNA sequencing analysis revealed that cluster of differentiation 36 (CD36), a free fatty acid (FA) transport protein, was involved in the Ses-mediated inhibition of hepatic fat accumulation. Moreover, the overexpression of CD36 significantly increased hepatic steatosis in both Ses-treated PA/OA-incubated HepG2 cells and NASH mice. Furthermore, Ses treatment suppressed insulin-induced de novo ...
Source: Biochemical Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Ya-Ping Bai Teng Zhang Zheng-Yan Hu Yan Zhang De-Guo Wang Meng-Yun Zhou Ying Zhang Fang Zhang Xiang Kong Source Type: research
Remnant cholesterol, LDL cholesterol, and apoB absolute mass changes explain results of the PROMINENT trial
CONCLUSIONS: Absolute mass changes in remnant cholesterol, LDL cholesterol, and apolipoprotein B can explain results of the PROMINENT trial. The 3 mg/dL (0.08 mmol/L) higher total atherogenic cholesterol together with 5 mg/dL (0.05 g/L) higher apolipoprotein B seem to explain the trend toward more ASCVD in the pemafibrate arm.PMID:38678642 | DOI:10.1016/j.atherosclerosis.2024.117556 (Source: Atherosclerosis)
Source: Atherosclerosis - April 28, 2024 Category: Cardiology Authors: Takahito Doi Anne Langsted B ørge G Nordestgaard Source Type: research
Transcriptomic analysis reveals the critical role of Chemokine signaling in the anti-atherosclerosis effect of Xuefu Zhuyu Decoction
CONCLUSION: Xuefu Zhuyu decoction demonstrates effective regulation of plaque components, retarding plaque progression and preserving plaque stability by modulating lipid metabolism and inflammatory responses. Subsequent transcriptome analysis identified the cytokine-cytokine receptor interaction and chemokine signaling pathway as potential key pathways for the therapeutic effects of Xuefu Zhuyu decoction. This insight not only provides crucial avenues for further exploration into the mechanisms underlying Xuefu Zhuyu decoction but also offers valuable perspectives and hypotheses for enhancing disease prevention and treatm...
Source: Atherosclerosis - April 28, 2024 Category: Cardiology Authors: Dongdong Jia Mengzhu Zhao Xinyue Zhang Xu Cheng Qiong Wei Lixia Lou Yizhou Zhao Qiushuo Jin Meng Chen Dongmei Zhang Source Type: research
A comparative study of multiple biomarkers levels in complicated versus noncomplicated type 2 diabetic patients
In conclusion, there were significant differences in biomarker concentrations between all three groups. This indicates that the monitoring of multiple biomarkers may be of value in the controlling of T2DM in the future.PMID:38678628 | DOI:10.14715/cmb/2024.70.4.8 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Hemin Mohamad Hussein Ahmed Alkhuzai Christer Janson Kawa Amin Source Type: research
Relationship between changes in blood glucose, glycosylated hemoglobin [HbA1c], cholesterol, and triglyceride and changes in hepatic enzymes
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):23-28. doi: 10.14715/cmb/2024.70.4.4.ABSTRACTThe main risk factors for non-alcoholic fatty liver disease (NAFLD) are strongly associated with obesity, diabetes, hyperlipidemia, and metabolic syndrome. The best clinical evaluation of the liver is done through studying changes in liver enzymes' activity, especially alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase. Therefore, this study aimed to investigate the relationship between changes in factors such as blood glucose, cholesterol, glycosylated hemoglobin, and triglyceride and changes in hepat...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Mahboobeh Talebi Mehrdar Wei Lu Adel Rahanjam Source Type: research
Optimizing lipid control in Taiwanese diabetic patients: A collaborative consensus by the Diabetes Association of the Republic of China (Taiwan) and the Taiwanese Association of Diabetes Educators
We present an in-depth analysis of dyslipidemia management strategies for patients with diabetes mellitus in Taiwan. It critically examines the disparity between established guideline recommendations and actual clinical practices, particularly in the context of evolving policies affecting statin prescriptions. The focus is on synthesizing the most recent findings concerning lipid management in patients with diabetes mellitus, with a special emphasis on establishing consensus regarding low-density lipoprotein cholesterol treatment targets. The article culminates in providing comprehensive, evidence-based recommendations tai...
Source: Journal of Diabetes Investigation - April 28, 2024 Category: Endocrinology Authors: Feng ‐Chih Shen,
Chih‐Hsun Chu,
Jung‐Fu Chen,
Chin‐Sung Kuo,
Chih‐Yao Hsu,
Ching‐Han Lin,
Yi‐Jing Sheen,
Sheng‐Chiang Su,
Kai‐Jen Tien,
Chieh‐Hua Lu,
Chun‐Chuan Lee,
Yi‐Sun Yang,
Shih‐Te Tu,
Po‐Tsang Chen,
Ching Tags: Special Research Report Source Type: research
Uncovering the Role of Anmeidan against Atherosclerosis from Integrated Network Pharmacology and Pharmacological Experiments
CONCLUSIONS: This study confirmed that AMD could treat AS by regulating lipid metabolism and preliminarily explored the related mechanism. These findings provide new ideas for the treatment of AS with TCM.PMID:38676497 | DOI:10.2174/0113862073281925240417062009 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Yuting Zheng Jianxiang Wang Chengcheng Pan Jihong Song Xingyue Li Wenjing Ta Wen Lu Source Type: research
High throughput microfluidics-based synthesis of PEGylated liposomes for precise size control and efficient drug encapsulation
Colloids Surf B Biointerfaces. 2024 Apr 22;238:113926. doi: 10.1016/j.colsurfb.2024.113926. Online ahead of print.ABSTRACTThe low scalability and reproducibility of existing synthesis methods have hindered the translation of liposome nanoparticles as carriers for targeted drug delivery from conventional laboratory techniques to mass production. To this end, in this study, we present a high-throughput microfluidics-based approach for the synthesis of PEGylated liposomes with a primary focus on achieving precise size control and efficient encapsulation of hydrophobic drug molecules. In this platform, liposomes were self-asse...
Source: Colloids and Surfaces - April 27, 2024 Category: Biotechnology Authors: Shima Akar Somayeh Fardindoost Mina Hoorfar Source Type: research
Per- and polyfluoroalkyl substances induce lipid metabolic impairment in fish: Integration on field investigation and laboratory study
This study innovatively explored the adverse effects of PFOS and F-53B on lipid metabolism and their mechanisms at field and laboratory levels, highlighting concerns regarding PFASs health risks.PMID:38677088 | DOI:10.1016/j.envint.2024.108687 (Source: Environment International)
Source: Environment International - April 27, 2024 Category: Environmental Health Authors: Qiyu Wang Xueyan Gu Limin Mo Nannan Wan Liu Wu Shuai Liu Miao Zhang Mingqi Li Xi Liu Yu Liu Source Type: research
Uncovering the Role of Anmeidan against Atherosclerosis from Integrated Network Pharmacology and Pharmacological Experiments
CONCLUSIONS: This study confirmed that AMD could treat AS by regulating lipid metabolism and preliminarily explored the related mechanism. These findings provide new ideas for the treatment of AS with TCM.PMID:38676497 | DOI:10.2174/0113862073281925240417062009 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Yuting Zheng Jianxiang Wang Chengcheng Pan Jihong Song Xingyue Li Wenjing Ta Wen Lu Source Type: research
Ginseng polysaccharide components attenuate obesity and liver lipid accumulation by regulating fecal microbiota and hepatic lysine degradation
In this study, we found that PGP inhibited the high-fat diet (HFD)-induced weight gain, fat ratio and fat tissue weight after 8-week administration. Serum and liver lipid analysis showed that PGP decreased the levels of triglyceride and total cholesterol, which was mediated by the inhibition of key genes for fatty acid and cholesterol metabolisms. Metabolomics studies showed that the inhibitory effect of PGP on liver lipid accumulation was significantly correlated with its regulation of citric acid cycle and lysine degradation. PGP regulated the expression of genes related to lysine degradation in both liver tissue and hep...
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Qing Liu Zepeng Zhang Peng Ji Jiaqi Liu Boxue Chen E Mingyao Hongyu Qi Tong Hou Qingxia Huang Lu Ding Chen Guo Daqing Zhao Wenzhi Yang Zeyu Wang Xiangyan Li Source Type: research
Examination of eating competence in a geo-diverse sample with metabolic syndrome
Appetite. 2024 Apr 25:107373. doi: 10.1016/j.appet.2024.107373. Online ahead of print.ABSTRACTEating competence (EatC) is an intra-individual approach to eating attitudes and behaviors associated with greater well-being. EatC research has not included persons with confirmed metabolic syndrome (MetS). Therefore, EatC of persons with MetS was explored to identify unique associations and inform implementation of MetS lifestyle interventions using baseline data from a multisite, randomized trial of a 2-year lifestyle intervention with MetS. EatC, measured with the Satter Eating Competence Inventory 2.0 (ecSI 2.0™), was exami...
Source: Appetite - April 27, 2024 Category: Nutrition Authors: Barbara Lohse Bong Nguyen Betty M Drees Lisa Bailey-Davis Kevin S Masters Jacinda Nicklas Bryce Daniels Elizabeth H Ruder Nicole Trabold Source Type: research
Therapeutic potentials of Hibiscus trionum: Antioxidant, anti-lipid peroxidative, hypoglycemic, and hepatoprotective effects in type 1 diabetic rats
This study investigated the impact of Hibiscus trionum on glycemic control and assessed its influence on glucose and insulin levels in diabetes-induced rats. The concentrations of antioxidant enzymes, particularly superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), were scrutinized across multiple body tissues (plasma, heart, muscle, liver, and kidney). The malondialdehyde (MDA) concentration, an indicator of lipid peroxidation, was examined in both plasma and tissue samples. Serum total cholesterol (TC), triglyceride (TG), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels were evaluat...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 27, 2024 Category: Drugs & Pharmacology Authors: Sedef Ziyanok-Demirtas Source Type: research
