Evaluation of anti-seizure medications and their serum concentration with regard to cardiovascular risk parameters: A cross-sectional study
CONCLUSION: In our study, the majority of patients were children and adolescents. Regular monitoring of drug serum concentrations and metabolic parameters may be useful to select the safest drug in terms of cardiovascular disease risk. Randomized controlled trials on the long-term effects of anti-seizure treatment are needed.PMID:38657483 | DOI:10.1016/j.yebeh.2024.109802 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 24, 2024 Category: Neurology Authors: Merve Becit-Kizilkaya Seyma Oncu Halit Bugra Koca Dilek Cavusoglu Source Type: research
Inappropriate laboratory test utilization in outpatient tertiary care: Implications for value-based healthcare
CONCLUSION: The study identified significantly high rates of inadequate repetitions of frequently requested laboratory tests. Urgent action is therefore crucial to overcoming such an issue.PMID:38657991 | DOI:10.15537/smj.2024.45.4.20230512 (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - April 24, 2024 Category: Middle East Health Authors: Nouf F Almasoud Mohammed A Aldosari Ahmed S Mahmoud Yaser A Alendijani Abdullah H Alkhenizan Source Type: research
PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury
This study aimed to assess the effects of alirocumab, a monoclonal antibody targeting PCSK9 to lower systemic low-density lipoprotein cholesterol (LDL-C), on central nervous system (CNS) pathology in a rat model of chronic alcohol exposure. Alirocumab (50 mg/kg) or vehicle was administered weekly for six weeks in 32 male rats subjected to a 35 % ethanol liquid diet or a control liquid diet (n = 8 per group). The study evaluated PCSK9 expression, LDL receptor (LDLR) expression, oxidative stress, and neuroinflammatory markers in brain tissues. Chronic ethanol exposure increased PCSK9 expression in the brain, while alirocumab...
Source: Brain, Behavior, and Immunity - April 24, 2024 Category: Neurology Authors: Josephin Wagner Lauren M Park Partha Mukhopadhyay Csaba Matyas Eszter Trojnar Ruslan Damadzic Jeesun Jung Andrew S Bell Lucas A Mavromatis Ali M Hamandi Daniel B Rosoff Leandro F Vendruscolo George F Koob Pal Pacher Falk W Lohoff Source Type: research
Association between lipoprotein(a) and cardiovascular disease in patients undergoing coronary angiography
CONCLUSION: The findings indicated that elevated lipoprotein(a) had no obvious relationship with hypertension and obesity. Elevated lipoprotein(a) increases the risk of high total cholesterol, high LDL‑c, and premature CAD, and increases the occurrence and severity of coronary heart disease.PMID:38658408 | DOI:10.1007/s00059-024-05247-0 (Source: Herz)
Source: Herz - April 24, 2024 Category: Cardiology Authors: Azhi ShaMa Chunmei Xu Yingying Huang Chunlan Ma Jingyue Hu Zhuxin Li Chunyu Zeng Source Type: research
Treatment patterns and adherence to lipid-lowering drugs during eight-year follow-up after a coronary heart disease event
CONCLUSIONS: In this long-term follow-up of patients with CHD, less than 70 % used high-intensity statin therapy with only small changes over time, and only 25 % used additional treatment with ezetimibe. We identified factors associated with reduced statin adherence that may be target for interventions.PMID:38657552 | DOI:10.1016/j.atherosclerosis.2024.117550 (Source: Atherosclerosis)
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Ingrid Engebretsen Christoffer Bugge Henrik St øvring Einar Husebye Elise Sverre Toril Dammen Sigrun Halvorsen John Munkhaugen Source Type: research
UHRF1 inhibition mitigates vascular endothelial cell injury and ameliorates atherosclerosis in mice via regulating the SMAD7/YAP1 axis
CONCLUSION: UHRF1 inhibition mitigates vascular endothelial cell injury and ameliorates AS progression in mice by regulating the SMAD7/YAP1 axis.PMID:38657333 | DOI:10.1016/j.molimm.2024.04.001 (Source: Atherosclerosis)
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Wenbo Li Pengxing Bai Wei Li Source Type: research
Comparison of the blood biochemical values of foraging and nesting Olive Ridley turtles (Lepidochelys olivacea) from Sinaloa, Mexico
Mar Environ Res. 2024 Apr 10;198:106491. doi: 10.1016/j.marenvres.2024.106491. Online ahead of print.ABSTRACTOur study aimed to establish reference values for nesting females and compare them with those previously reported to understand olive ridley turtles' health status and contribute to long-term health assessment and monitoring in foraging and nesting areas from the state of Sinaloa, Mexico. In August and September 2018, morphometric data and biochemical profiles were collected from 33 nesting olive ridley turtles from Ceuta Beach Sanctuary (CBS) and 14 foraging female turtles captured at the foraging site, Navachiste ...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Jorge Vald és-Flores C ésar P Ley-Quiñonez Nidia Le ón-Sicairos Hector Flores-Villase ñor Jorge Vel ázquez-Román Uriel Angulo-Zamudio Alan Zavala-Norzagaray Catherine E Hart Vicente Olim ón-Andalón Renato Leal-Moreno Ingmar Sosa-Cornejo A Alonso Source Type: research
Effects of a dietary intervention on cardiometabolic risk and food consumption in a workplace
by Archana Shrestha, Dipesh Tamrakar, Bhawana Ghinanju, Deepa Shrestha, Parashar Khadka, Bikram Adhikari, Jayana Shrestha, Suruchi Waiwa, Prajjwal Pyakurel, Niroj Bhandari, Biraj Man Karmacharya, Akina Shrestha, Rajeev Shrestha, Rajendra Dev Bhatta, Vasanti Malik, Josiemer Mattei, Donna Spiegelman
BackgroundWorksite-based health programs have shown positive impacts on employee health and have led to significant improvements in cardiovascular risk factor profiles. We aimed to determine the effect of cafeteria intervention on cardio-metabolic risk factors diet in a worksite setting (Dhulikhel Hospital) in Nepal. MethodsIn th...
Source: PLoS One - April 24, 2024 Category: Biomedical Science Authors: Archana Shrestha Source Type: research
The association of the platelet/high-density lipoprotein cholesterol ratio with self-reported stroke and cardiovascular mortality: a population-based observational study
Previous studies have shown that the relationship between high-density lipoprotein cholesterol (HDL-C) and stroke is controversial, and the association between the platelet/high-density lipoprotein cholesterol... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 24, 2024 Category: Lipidology Authors: Huifeng Zhang, Ying Xu and Yaying Xu Tags: Research Source Type: research
Association between serum 25 ‐hydroxyvitamin D level and inflammatory markers in hemodialysis‐treated patients
ConclusionCollectively, serum 25(OH)D level has a negative correlation with inflammatory markers. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 23, 2024 Category: Allergy & Immunology Authors: Chunlei Luo,
Xueyan Bian,
Lingling Bao,
Qingqing Xu,
Chunyang Ji Tags: ORIGINAL ARTICLE Source Type: research
No effect of liraglutide on high density lipoprotein apolipoprotein AI kinetics in patients with type 2 diabetes
CONCLUSION: Six months of treatment with 1.2 mg/day of liraglutide had no effect on the kinetics of HDL apoAI in patients with T2D. The lack of decrease in triglyceride content in HDL related to an only moderate decrease in triglyceridemia, probably greatly explains these results. Insufficient improvement of insulin sensitivity and adiponectinemia may also be implied.PMID:38653365 | DOI:10.1016/j.diabet.2024.101535 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - April 23, 2024 Category: Endocrinology Authors: Laurence Duvillard Jean-Paul Pais de Barros Alexia Rouland Isabelle Simoneau Damien Denimal Benjamin Bouillet Jean-Michel Petit Bruno Verg ès Source Type: research
Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
This article reviews the recent research progress of GLP-1 in lipid metabolism.PMID:38650100 | DOI:10.4093/dmj.2023.0277 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 23, 2024 Category: Endocrinology Authors: Tong Bu Ziyan Sun Yi Pan Xia Deng Guoyue Yuan Source Type: research
No effect of liraglutide on high density lipoprotein apolipoprotein AI kinetics in patients with type 2 diabetes
CONCLUSION: Six months of treatment with 1.2 mg/day of liraglutide had no effect on the kinetics of HDL apoAI in patients with T2D. The lack of decrease in triglyceride content in HDL related to an only moderate decrease in triglyceridemia, probably greatly explains these results. Insufficient improvement of insulin sensitivity and adiponectinemia may also be implied.PMID:38653365 | DOI:10.1016/j.diabet.2024.101535 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - April 23, 2024 Category: Endocrinology Authors: Laurence Duvillard Jean-Paul Pais de Barros Alexia Rouland Isabelle Simoneau Damien Denimal Benjamin Bouillet Jean-Michel Petit Bruno Verg ès Source Type: research
No effect of liraglutide on high density lipoprotein apolipoprotein AI kinetics in patients with type 2 diabetes
CONCLUSION: Six months of treatment with 1.2 mg/day of liraglutide had no effect on the kinetics of HDL apoAI in patients with T2D. The lack of decrease in triglyceride content in HDL related to an only moderate decrease in triglyceridemia, probably greatly explains these results. Insufficient improvement of insulin sensitivity and adiponectinemia may also be implied.PMID:38653365 | DOI:10.1016/j.diabet.2024.101535 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - April 23, 2024 Category: Endocrinology Authors: Laurence Duvillard Jean-Paul Pais de Barros Alexia Rouland Isabelle Simoneau Damien Denimal Benjamin Bouillet Jean-Michel Petit Bruno Verg ès Source Type: research
Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
This article reviews the recent research progress of GLP-1 in lipid metabolism.PMID:38650100 | DOI:10.4093/dmj.2023.0277 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 23, 2024 Category: Endocrinology Authors: Tong Bu Ziyan Sun Yi Pan Xia Deng Guoyue Yuan Source Type: research
