Prognostic value of DCTA scoring system in heart failure.
CONCLUSION: D‑dimer, total cholesterol, hs-cTnT, and serum albumin levels were independent prognostic factors in the setting of heart failure. A novel and comprehensive scoring system based on these biomarkers is an easily available and effective tool for predicting the adverse outcomes of patients with heart failure. PMID: 33084909 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - October 22, 2020 Category: Cardiology Tags: Herz Source Type: research

[Echocardiographic examinations in times of the COVID-19 pandemic : International recommendations and implementation].
This article summarizes the current recommendations of international societies and describes the local implementation in Austria. PMID: 33064159 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - October 20, 2020 Category: Cardiology Tags: Herz Source Type: research

[Heart failure protection by SGLT2 inhibitors in patients with type  2 diabetes mellitus: evidence and possible mechanisms : A systematic review].
CONCLUSION: The SGLT2 inhibitors show a moderate heart failure protective effect in diabetic patients. It is likely that a nephroprotective effect with modulation of the cardiorenal interaction is an important part of the mechanism of action but this must be substantiated in further investigations. PMID: 33044563 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - October 14, 2020 Category: Cardiology Tags: Herz Source Type: research

[Aortic stenosis-which diagnostic algorithms and which treatment?]
Authors: Erbel R Abstract The progress in cardiology during the last 50 years can best be studied by looking at the diagnostics and treatment of patients with aortic valve stenosis. Previously, the clinical examination, electrocardiography (ECG) and chest X‑ray were used before heart catheterization, which included a transseptal puncture to complete the indications for surgery in young patients. Nowadays, echocardiography, often combined with a dobutamine stress test, is the primary diagnostic tool to which computed tomography for quantification of valve calcification and cardiac magnetic resonance...
Source: Herz - October 10, 2020 Category: Cardiology Tags: Herz Source Type: research

Effects of SARS-CoV-2 and its functional receptor ACE2 on the cardiovascular system.
Authors: Li M, Chen S, Xiang X, Wang Q, Liu X Abstract The clinical manifestations of COVID-19 are mainly respiratory symptoms, but some patients present with cardiovascular system disease such as palpitations and shortness of breath as the first or secondary symptoms. In this paper, we describe the characteristics of SARS-CoV‑2 and its functional receptor angiotensin-converting enzyme 2 (ACE2). Furthermore, we explore the impact of virus-induced myocardial damage, decreased ACE2 activity, immune imbalance, hypoxemia, and heart damage caused by antiviral drugs. PMID: 33025029 [PubMed - as supplied by pub...
Source: Herz - October 8, 2020 Category: Cardiology Tags: Herz Source Type: research

Outcomes after transcatheter aortic valve replacement in older patients.
Authors: Kara K, Kloppe A, Ewers A, Bösche L, Aweimer A, Erdogan H, Schöne D, Schiedat F, Patsalis N, Haldenwang PL, Strauch JT, Mügge A, Patsalis PC Abstract BACKGROUND: The prevalence of aortic valve stenosis is increasing due to the continuously growing geriatric population. Data on procedural success and mortality of very old patients are sparse, raising the question of when this population may be deemed as "too old even for transcatheter aortic valve replacement (TAVR)." We, therefore, sought to evaluate the influence of age on outcome after TAVR and the impact of direct implantation. ...
Source: Herz - October 8, 2020 Category: Cardiology Tags: Herz Source Type: research

Reduced rate of admissions for acute coronary syndromes during the COVID-19 pandemic: an observational analysis from a  tertiary hospital in Germany.
Reduced rate of admissions for acute coronary syndromes during the COVID-19 pandemic: an observational analysis from a tertiary hospital in Germany. Herz. 2020 Oct 07;: Authors: Vacanti G, Bramlage P, Schymik G, Schmitt C, Luik A, Swojanowsky P, Tzamalis P Abstract BACKGROUND: Several observational studies have suggested a worrying reduction in hospitalisations for acute coronary syndromes in the emergency cardiology department in the last few months all over the world. The aim of the present study is to assess the impact of the current COVID-19 health crisis on admission for acute coronary s...
Source: Herz - October 8, 2020 Category: Cardiology Tags: Herz Source Type: research

Influence of ablation index on the incidence of cardiac tamponade complicating pulmonary vein isolation.
Authors: Reinsch N, Füting A, Buchholz J, Ruprecht U, Neven K Abstract BACKGROUND: Cardiac tamponade (CT) complicating pulmonary vein isolation (PVI) for atrial fibrillation (AF) is a complication that can increase morbidity and mortality. Radiofrequency energy is a known cause of CT. Ablation Index (AI) is a novel ablation quality marker. We hypothesized that use of AI reduces the incidence of CT. METHODS: All AF procedures between 10/2014 and 06/2019 were included. Three ablation groups were defined: group A, RF ablation with non-contact force (CF) catheter; group B, RF ablation ...
Source: Herz - October 8, 2020 Category: Cardiology Tags: Herz Source Type: research

[Hair cortisol as chronic stress parameter in patients with acute ST-segment elevation myocardial infarction].
CONCLUSION: The results of this study showed that patients with acute ST-segment elevation myocardial infarction did not have significantly higher levels of hair cortisol compared to the reference group; however, long-term metabolic changes as well as advanced chronic heart failure appear to be long-acting stress factors for the organism and increase cortisol levels in hair. PMID: 33026485 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - October 8, 2020 Category: Cardiology Tags: Herz Source Type: research

Transvenous extraction of pacemaker leads via femoral approach using a  gooseneck snare.
Transvenous extraction of pacemaker leads via femoral approach using a gooseneck snare. Herz. 2020 Oct 02;: Authors: Uslu A, Küp A, Kanar BG, Balaban I, Demir S, Gülşen K, Kepez A, Doğan C, Candan Ö, Akgün T, Altıntas B, Sadıc BO Abstract BACKGROUND: The growing problem of endocardial lead infections and lead malfunctions has increased interest in percutaneous lead-removal technology. Transvenous lead extraction (TLE) via simple manual traction (SMT) is the first-line therapy. When SMT is not successful, TLE from the femoral vein using a gooseneck snare (GS) with a&nbs...
Source: Herz - October 5, 2020 Category: Cardiology Tags: Herz Source Type: research

Heart failure with preserved ejection fraction, atrial fibrillation, and increased NT ‑proBNP levels : An emergent clinical dilemma.
CONCLUSION: Patients with HFpEF and AF have higher levels of NT-proBNP, which may exceed the upper limits defined in guidelines. This study underlines the importance of measuring NT-proBNP levels in the stable phase and proposes a rule-in level for the decompensated phase. PMID: 32997152 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - October 2, 2020 Category: Cardiology Tags: Herz Source Type: research

Pulmonary hypertension due to left heart disease with pulmonary arterial wedge pressure ≤15 mm Hg.
CONCLUSION: We found that 15.6% of the patients with PH-LHD under pharmacological or nonpharmacological treatment had PAWP ≤15 mm Hg. These results suggest that the diagnostic criterion of PAWP and the characteristics for this group of patients should be further investigated. PMID: 32990814 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - October 1, 2020 Category: Cardiology Tags: Herz Source Type: research

[Comparison between chest pain units and stroke units : Essential components of the vascular emergency care system: comparison of structure, certification process, quality benchmarking and reimbursement].
CONCLUSION: The well-established CPU concept could additionally benefit from a superordinate quality control. Adequate quality benchmarking appears to be fundamental for gap analyses and for the establishment of a separate remuneration structure. In this respect the German Society for Cardiology as the certifying institution is required to establish an appropriate mechanism within the framework of regular updates of criteria. PMID: 32990815 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - October 1, 2020 Category: Cardiology Tags: Herz Source Type: research

Current evidence of survival benefit between chest-compression only versus standard cardiopulmonary resuscitation in out-of-hospital cardiac arrest : Updated systematic review and meta-analysis of randomized controlled trials with trial sequential analysis.
CONCLUSION: Based on these analyses, evidence is inadequate to conclude the superiority of one CPR method over the other. Further trials with larger numbers of patients are needed to deem a conclusive and stable meta-analysis. PMID: 32975628 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - September 26, 2020 Category: Cardiology Tags: Herz Source Type: research

Evaluation of thrombolytic treatment effect on frontal plane QRS-T angle in patients with acute pulmonary embolism : A  novel marker of successful thrombolysis.
CONCLUSION: Right ventricular pressure overload in APE has an effect on f(QRS-T). In thrombolytic treatment, the change of f(QRS-T) angle may be a marker of successful thrombolysis. PMID: 32975629 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - September 26, 2020 Category: Cardiology Tags: Herz Source Type: research

Impact of postdischarge care fragmentation on clinical outcomes and survival following transcatheter aortic valve replacement.
Authors: Karacop E, Enhos A, Bakhshaliyev N Abstract BACKGROUND: The study aimed to evaluate the prognostic impact of postdischarge care fragmentation in patients undergoing transcatheter aortic valve replacement (TAVR). METHODS: A total of 266 patients undergoing TAVR due to severe aortic stenosis were included in this retrospective cohort study. Patients were assigned to one of two groups based on presence (n = 104) and absence (n = 162) of postdischarge care fragmentation. Fragmented care was defined as at least one readmission to a site other than the implanting TAVR center withi...
Source: Herz - September 11, 2020 Category: Cardiology Tags: Herz Source Type: research

Amelioration of ischemic cardiomyopathy in patients using physiological ischemic training.
This study aimed to observe the effect and potential mechanism of physiological ischemic training (PIT) in patients with ischemic cardiomyopathy. METHODS: A total of 165 patients with ischemic cardiomyopathy were randomly selected by the convenience sampling method and were divided into the control and experimental groups. The control group received conventional drug treatment, while the experimental group received additional PIT. All patients were followed up for 6 months and renin-angiotensin-aldosterone system (RAS) activity parameters and myocardial remodeling indicators were recorded. RESULTS: After ...
Source: Herz - September 5, 2020 Category: Cardiology Tags: Herz Source Type: research

[Acute myocardial infarction-actual issues].
Authors: Thiele H, Zahn R PMID: 32876779 [PubMed - in process] (Source: Herz)
Source: Herz - September 4, 2020 Category: Cardiology Tags: Herz Source Type: research

Mirror-image dextrocardia: why is the apex impulse not on the right?
This article presents the case of an 11-year-old girl with a history of Fortan surgery who presented to the authors' department with shortness of breath, orthopnea, and cyanosis. Electrocardiography (ECG) was indicative of mirror-image dextrocardia despite location of the apex impulse on the left. Echocardiography suggested mirror-image dextrocardia accompanied by levoversion, a large atrial septal defect and left ventricular atresia (functional single atrium and single ventricle), and right ventricular hypertrophy. ECG with corrected leads placement showed a sinus rhythm, biatrail enlargement, and right ventricular hypert...
Source: Herz - August 13, 2020 Category: Cardiology Tags: Herz Source Type: research

A simple formula to predict echocardiographic diastolic dysfunction-electrocardiographic diastolic index.
Authors: Hayıroğlu Mİ, Çınar T, Çiçek V, Asal S, Kılıç Ş, Keser N, Uzun M, Orhan AL Abstract BACKGROUND: Diastolic dysfunction (DD) in transthoracic echocardiography (TTE), which is a poorly understood entity due to its limited treatment, is frequently encountered in daily clinical practice of cardiology. An electrocardiographic (ECG) index to predict echocardiographic DD has not been elucidated yet. We aim to exhibit an electrocardiographic diastolic index (EDI) to predict TTE DD with high sensitivity and specificity. MATERIALS AND METHODS: In this retrospective investig...
Source: Herz - August 13, 2020 Category: Cardiology Tags: Herz Source Type: research

Noninvasive functional testing after ISCHEMIA: gatekeeper or phased-out model?
Authors: Dörr R, Thiele H PMID: 32728761 [PubMed - in process] (Source: Herz)
Source: Herz - August 1, 2020 Category: Cardiology Tags: Herz Source Type: research

New oral anticoagulants for nonvalvular atrial fibrillation with peripheral artery disease: a  meta-analysis.
CONCLUSION: The findings show that NOACs are effective and safe for preventing stroke/SE in patients with both NVAF and PAD. PMID: 32728781 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - August 1, 2020 Category: Cardiology Tags: Herz Source Type: research

Erratum to: Outcomes of anatomical vs. functional testing for coronary artery disease : Lessons from the major trials.
Authors: Karády J, Taron J, Kammerlander AA, Hoffmann U Abstract In the above-mentioned article, in the section "Other randomized controlled studies, meta-analyses, and registry data" two subheadings were swapped by mistake. The sections concerned must instead be headed as …. PMID: 32632546 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - July 9, 2020 Category: Cardiology Tags: Herz Source Type: research

[Therapeutic management of nonvalvular atrial fibrillation].
Authors: Gunawardene MA, Hartmann J, Jularic M, Eickholt C, Gessler N, Willems S Abstract Atrial fibrillation (AF) is the most frequent persistent cardiac arrhythmia and is associated with an increased mortality. Therefore, an effective differential treatment of patients is mandatory. After a risk stratification oral anticoagulation (OAC) should be initiated depending on the individual stroke risk of each patient. Alternatively, in the presence of contraindications for OAC and an increased risk for bleeding and/or stroke, the implantation of a left atrial appendage closure device can be considered. Symptomatic pati...
Source: Herz - July 9, 2020 Category: Cardiology Tags: Herz Source Type: research

Left atrial volume index and pulmonary arterial pressure predicted MACE among patients with STEMI during 8-year follow-up: experience from a  tertiary center.
CONCLUSION: In patients that underwent P‑PCI for the treatment for STEMI, LVEF, LAVI, PAP and creatinine level independently predicted all-cause mortality and new onset HF during long-term follow-up. PMID: 32632548 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - July 9, 2020 Category: Cardiology Tags: Herz Source Type: research

Modified SAMe-TT2R2 score for predicting the therapeutic range of digoxin.
Authors: Karataş MB, Çanga Y, Yelgeç NS, Zengin A, Güzelburç Ö, Eren S, Emre A Abstract BACKGROUND: Digoxin treatment has come under scrutiny in recent years after reports from several studies that it is associated with increased mortality in patients with atrial fibrillation (AF). The clinical effects of digoxin on mortality were closely related to serum digoxin concentrations (SDC) in these studies. In the present work, we evaluated the role of the SAMe-TT2R2 and modified SAMe-TT2R2 scores in predicting the therapeutic range of digoxin therapy. METHODS: Medical records from our...
Source: Herz - July 9, 2020 Category: Cardiology Tags: Herz Source Type: research

[Troponin elevation in acute ischemic stroke-unspecific or acute myocardial infarction? : Diagnostics and clinical implications].
Authors: Kruska M, Fastner C, Scheitz JF, Kolb A, Rutsch M, Papavassiliu T, Borggrefe M, Alonso A, Akin I, Szabo K, Baumann S Abstract Routine determination of troponin levels is recommended for all patients with acute ischemic stroke. In 20-55% of these patients the troponin levels are elevated, which may be caused by ischemic as well as non-ischemic myocardial damage and particularly neurocardiogenic myocardial damage. In patients with acute ischemic stroke, the prevalence of previously unknown coronary heart disease is reported to be up to 27% and is prognostically relevant for these patients; however, relevant ...
Source: Herz - July 9, 2020 Category: Cardiology Tags: Herz Source Type: research

After ISCHEMIA: Is coronary CTA the new gatekeeper?
Authors: Smolka S, Desai MY, Achenbach S Abstract The ISCHEMIA trial investigated two major principles in the therapy of coronary artery disease (CAD), i.e., symptom relief and improvement of prognosis. Specifically, it was designed to answer the question of whether, after ruling out left main stenosis, a routine interventional strategy in addition to optimal medical therapy can improve clinical outcome. Overall, this hypothesis could not be confirmed. Nevertheless, the trial yields interesting new aspects in the field of cardiac imaging. As a noninvasive diagnostic approach for individuals with suspected...
Source: Herz - July 7, 2020 Category: Cardiology Tags: Herz Source Type: research

Erratum to: After ISCHEMIA: Is cardiac MRI a  reliable gatekeeper for invasive angiography and myocardial revascularization?
Erratum to: After ISCHEMIA: Is cardiac MRI a reliable gatekeeper for invasive angiography and myocardial revascularization? Herz. 2020 Jul 01;: Authors: Nagel E, Carerj ML, Arendt CT, Puntmann VO Abstract In the above mentioned article, the family name of the second author was not given correctly: it is Carerj instead of Careri.The authors apologize for this mistake.The original article has been …. PMID: 32613316 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - July 3, 2020 Category: Cardiology Tags: Herz Source Type: research

[New oral antidiabetic drugs].
Authors: Müller-Wieland D, Schütt K, Brandts J, Marx N Abstract A paradigm change in the treatment of type 2 diabetes has recently emerged due to the introduction of new oral antidiabetic agents. Cardiovascular endpoint studies confirmed the safety of dipeptidyl peptidase 4 (DPP-4) inhibitors and a cardiovascular protective effect for glucagon-like peptide 1 (GLP-1) receptor agonists and sodium-glucose linked transporter 2 (SGLT-2) inhibitors. Furthermore, SGLT‑2 inhibitors reduce the risk for heart failure and have a renoprotective effect. These studies led to changes in clinical recommendations a...
Source: Herz - July 2, 2020 Category: Cardiology Tags: Herz Source Type: research

Establishing an oncocardiology service.
Authors: Lehmann LH, Totzeck M Abstract Oncocardiology is an emerging field in cardiovascular healthcare. Besides establishing surveillance and follow-up strategies for cancer patients, it will be essential to set up specialized oncocardiology services. However, there is a lack of clinical studies to give evidence-based recommendations regarding cardiological diagnostic and therapeutic approaches for cancer patients. An oncocardiology service is a patient-centered structure that aims to integrate research and interdisciplinary patient care to bridge this gap. We discuss the current challenges in developin...
Source: Herz - June 24, 2020 Category: Cardiology Tags: Herz Source Type: research

Echocardiography and biomarkers for the diagnosis of  cardiotoxicity.
Echocardiography and biomarkers for the diagnosis of cardiotoxicity. Herz. 2020 Jun 20;: Authors: Berliner D, Beutel G, Bauersachs J Abstract As a result of better treatment options for malignant cancer, the cardiovascular side effects of such therapies have increasingly come into focus in recent years. The new cardiological subspecialty of oncocardiology is developing strategies to prevent and/or detect those effects early in order to treat them in a timely and adequate manner. The diagnosis of cardiotoxic effects is based mainly on imaging and specific biomarkers. Echocardiography has ...
Source: Herz - June 23, 2020 Category: Cardiology Tags: Herz Source Type: research

Prevention and treatment of venous thromboembolism in cancer patients.
Authors: Spehlmann ME, Frey N, Müller OJ Abstract Deep vein thrombosis and pulmonary artery embolism are common and serious concomitant diseases in patients with cancer. The prophylaxis and therapy of such venous thromboembolic events (VTE) in oncology have so far been achieved with low-molecular-weight heparins. An increasing number of studies show evidence of the use of direct oral anticoagulants. However, since none of the possible options were shown to have a clear advantage in all patients, the individual decision to use a drug should be made depending on its effectiveness in preventing VTE, the...
Source: Herz - June 23, 2020 Category: Cardiology Tags: Herz Source Type: research

Erratum to: Left ventricular systolic dysfunction in patients with unprotected left main coronary artery disease.
Authors: Pan Y, Qiu Q, Ren WH, Yu XP, Liu ZS, Dong JZ Abstract In the above mentioned article, the first and last names of the fifth author were interchanged: Ze-sen Liu is the correct name, "Liu" being the family name and "Ze-sen" the first name.The publisher apologizes for this …. PMID: 32556381 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - June 20, 2020 Category: Cardiology Tags: Herz Source Type: research

Revascularization in cardiogenic shock.
Authors: Freund A, Desch S, Thiele H Abstract Approximately 10% of patients with acute myocardial infarction develop cardiogenic shock. Randomized studies have shown a significant improvement in survival with early revascularization, which now represents the most important cornerstone in the treatment of infarct-related cardiogenic shock. In the vast majority of cases, this is achieved by percutaneous coronary intervention (PCI). In cases of complex coronary anatomy or mechanical complications, the Heart Team should be consulted promptly. The randomized CULPRIT-SHOCK study showed a survival advantage for ...
Source: Herz - June 19, 2020 Category: Cardiology Tags: Herz Source Type: research

Radial access first for PCI in acute coronary syndrome : Are we propping up a  straw man?
Radial access first for PCI in acute coronary syndrome : Are we propping up a straw man? Herz. 2020 Jun 16;: Authors: Marbach JA, Alhassani S, Wells G, Le May M Abstract Coronary angiography and percutaneous coronary intervention (PCI) represent the recommended revascularization strategy for patients presenting with acute coronary syndrome (ACS). However, periprocedural bleeding events, of which up to 50% are related to the access site, remain an important complication of PCI and are associated with higher costs, prolonged hospital stays, and increased mortality. Several randomized trials have dem...
Source: Herz - June 19, 2020 Category: Cardiology Tags: Herz Source Type: research

Common genetic predisposition for heart failure and cancer.
Authors: Pfeffer TJ, Pietzsch S, Hilfiker-Kleiner D Abstract Cardiovascular diseases and cancer are major causes of mortality in industrialized societies. They share common risk factors (e.g., genetics, lifestyle, age, infection, toxins, and pollution) and might also mutually promote the onset of the respective other disease. Cancer can affect cardiac function directly while antitumor therapies may have acute- and/or late-onset cardiotoxic effects. Recent studies suggest that heart failure might promote tumorigenesis and tumor progression. In both cancer and cardiovascular diseases, genetic predisposition is implic...
Source: Herz - June 17, 2020 Category: Cardiology Tags: Herz Source Type: research

Emerging role of immune checkpoint inhibitors and their relevance for the cardiovascular system.
Authors: Michel L, Totzeck M, Lehmann L, Finke D Abstract Immune checkpoint inhibitor (ICI) therapy induces an immune response against cancer cells. Immune checkpoint inhibitor therapy has tremendously improved the prognosis for a large number of cancers, but is associated with considerable immune-related adverse events (irAEs). Cardiovascular complications from ICI therapy occur in a modest proportion of patients, but show the highest lethality rates of all ICI-related complications. While ICI-related myocarditis is the most dangerous complication, its clinical manifestation varies, e.g., asymptomatic re...
Source: Herz - June 15, 2020 Category: Cardiology Tags: Herz Source Type: research

Optimal antiplatelet and anticoagulation strategies in acute coronary syndromes.
Authors: Rath D, Geisler T Abstract Antithrombotic therapy has become increasingly challenging due to the thrombotic and bleeding risk of patients presenting with acute coronary syndrome (ACS) today. Contributing factors include increasing age, underlying comorbidities (e.g., renal failure, atrial fibrillation [AF]), or concomitant interventions including transcatheter valve procedures requiring individualized antithrombotic strategies. Thanks to the development of novel stent platforms with biocompatible polymers and thin strut design allowing for a more rapid endothelialization, shortening or de-escalation o...
Source: Herz - June 10, 2020 Category: Cardiology Tags: Herz Source Type: research

[Clinical implications of the fourth universal definition of myocardial infarction].
Authors: Eckner D, Pauschinger M, Ademaj F, Martinovic K Abstract This disease with its multiple ischemic and non-ischemic manifestations is classified based on the fourth universal definition of myocardial infarction (MI). An acute myocardial injury is defined as a significant increase of cardiac troponins (cTn). In patients with an additional myocardial ischemia, which is defined by certain clinical, electrocardiographic, imaging and angiographic criteria, the diagnosis of acute MI can be made. Etiologically, MI can be divided into 5 types: type 1 ischemic by plaque rupture or plaque erosion with t...
Source: Herz - June 10, 2020 Category: Cardiology Tags: Herz Source Type: research

Myocarditis in the era of SARS-CoV-2: one  piece of a complex puzzle?
Myocarditis in the era of SARS-CoV-2: one piece of a complex puzzle? Herz. 2020 Jun 08;: Authors: Polito MV, Ravera A PMID: 32514586 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - June 10, 2020 Category: Cardiology Tags: Herz Source Type: research

Oncocardiology: new challenges, new opportunities.
Authors: Michel L, Schadendorf D, Rassaf T Abstract Patients with cancer are at a higher risk of cardiovascular disease, which contributes to significant morbidity and mortality. The rapid progress in the field of oncological treatments has led to a steady increase in long-term cancer survivors. Care for cardiovascular complications is therefore becoming increasingly important. In addition, the establishment of new oncological therapies has resulted in the identification of previously unknown cardiovascular side effects. Oncocardiology aims to detect and treat cardiovascular diseases associated with cance...
Source: Herz - June 10, 2020 Category: Cardiology Tags: Herz Source Type: research

Outcomes of anatomical vs. functional testing for coronary artery disease : Lessons from the major trials.
Authors: Karády J, Taron J, Kammerlander AA, Hoffmann U Abstract Management of patients presenting with suspected stable coronary artery disease (CAD) are challenging because estimation of pretest probability for obstructive CAD remains difficult. In addition, identification of those who benefit from coronary revascularization remains ineffective regardless of the wide array of noninvasive testing alternatives available. Functional testing, which has long been considered to be the test of choice to risk stratify these patients, shows modest agreement with CAD severity detected by invasive coronary angiograph...
Source: Herz - June 7, 2020 Category: Cardiology Tags: Herz Source Type: research

[Is FFRCT a  game changer in coronary CT angiography?]
[Is FFRCT a game changer in coronary CT angiography?] Herz. 2020 Jun 03;: Authors: Gutberlet M, Krieghoff C, Gohmann R Abstract Coronary computed tomography angiography (CCTA) is already of great importance for the primary diagnostic testing for coronary artery disease (CAD) due to its high negative predictive value (NPV) and high sensitivity but, however, limited specificity. The specificity of invasive coronary angiography (ICA) could be increased by integrating the fractional flow reserve (FFR) into the invasive workflow with proof of the hemodynamic relevance of a morphologically detected...
Source: Herz - June 6, 2020 Category: Cardiology Tags: Herz Source Type: research

After ISCHEMIA: is invasive physiology the only remaining gatekeeper for myocardial revascularization in chronic coronary syndromes?
Authors: Kanoun S, Toth GG Abstract The International Study of Comparative Health Effectiveness With Medical And Invasive Approaches (ISCHEMIA) has the potential to be a game changer in terms of the diagnostic and management approach to patients presenting with chronic coronary syndrome, suggesting that coronary revascularization may become almost like a "bail-out" strategy in the treatment of these patients. However, invasive perfusion assessment as a means of detecting the source of myocardial ischaemia at a lesion level, such as fractional flow reserve (FFR), has been validated in t...
Source: Herz - June 6, 2020 Category: Cardiology Tags: Herz Source Type: research

Transcatheter therapies for severe tricuspid regurgitation. Quo  vadis?
Transcatheter therapies for severe tricuspid regurgitation. Quo vadis? Herz. 2020 May 28;: Authors: Alushi B, Vathie K, Thiele H, Lauten A Abstract Moderate-to-severe tricuspid regurgitation (TR) is common and is associated with a poor prognosis. To date, most patients are undertreated; therefore, transcatheter options could be clinically impactful in those who are denied surgery. Several transcatheter solutions have been developed that address the problem via leaflet enhancement, annuloplasty, or heterotopic implantation of self-expandable or balloon-expandable valves in the caval veins. A&n...
Source: Herz - May 31, 2020 Category: Cardiology Tags: Herz Source Type: research

Biomarkers for infarct diagnosis and rapid rule-out/rule-in of acute myocardial infarction.
Authors: Giannitsis E, Gopi V Abstract The 4th edition of the Universal Definition of Myocardial Infarction (MI) recommends measurement of cardiac troponin (cTn) T or I for the diagnosis of MI due to their absolute cardiac tissue specificity. In this MI definition, values exceeding the 99th percentile of a healthy reference population distinguish between detectable troponin due to physiological cell turnover as opposed to pathological myocardial injury. In clinical routine, high-sensitivity (hs) troponin assays that allow earlier diagnosis of MI and detection of myocardial injury that would have esca...
Source: Herz - May 31, 2020 Category: Cardiology Tags: Herz Source Type: research

Drug-coated balloon versus drug-eluting stent for treating de novo coronary lesions in large vessels: a  meta-analysis of clinical trials.
CONCLUSION: This meta-analysis indicated that DCB might be non-inferior to DES as evidenced by quantitative coronary angiography (QCA) assessed at 6-9 months after percutaneous coronary intervention in patients presenting with coronary artery disease. PMID: 32468141 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - May 31, 2020 Category: Cardiology Tags: Herz Source Type: research

Serum osteoprotegerin level is independently related to subclinical left atrial mechanical function in patients with hypertension and diabetes.
CONCLUSION: In hypertensive and diabetic patients, higher OPG values were associated with impaired LA function assessed by 2D-STE. In this high-risk patient group, serum OPG can be used as a risk predictor for LA mechanical dysfunction. PMID: 32462219 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - May 30, 2020 Category: Cardiology Tags: Herz Source Type: research

After ISCHEMIA: Is cardiac MRI a  reliable gatekeeper for invasive angiography and myocardial revascularization?
In conclusion, the results of the ISCHEMIA trial are in good accordance with those of the MR-INFORM trial recently published in the New England Journal of Medicine, as the noninvasive management of a large proportion of patients with CAD was shown to be noninferior to current invasive strategies. Recent outcome data from trials may therefore have an impact on future guidelines to further reduce the execution of unnecessary left heart catheterizations. PMID: 32458013 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - May 28, 2020 Category: Cardiology Tags: Herz Source Type: research