German chest pain unit registry: data review after the first decade of certification.
Authors: Breuckmann F, Rassaf T, Hochadel M, Giannitsis E, Münzel T, Senges J Abstract In 2008, the German Cardiac Society (GCS) introduced a certification program for specialized chest pain units (CPUs). In order to benchmark the performance of the certified CPUs, a nationwide German CPU registry was established. Since then, data for more than 34,000 patients have been included. The concept of certified CPUs in Germany has been widely accepted and its success is underlined by its recent inclusion in national and international guidelines. As of December 2019, 286 CPUs have been successfully certified...
Source: Herz - April 3, 2020 Category: Cardiology Tags: Herz Source Type: research

Takotsubo syndrome: between evidence, myths, and misunderstandings.
Authors: Napp LC, Bauersachs J Abstract Takotsubo syndrome (TS) is an acute cardiac condition characterized by transient wall motion abnormalities mostly of the left ventricle. First described in 1990, TS has gained substantial attention during the past 15 years. However, the disease is still underdiagnosed. Prospective studies on TS are largely lacking, and the condition remains incompletely understood. In addition, significant misconceptions and misunderstandings are evident, contributing to potentially severe underestimation. Here, we review important aspects of TS with a focus on pitfalls, misinterpre...
Source: Herz - March 25, 2020 Category: Cardiology Tags: Herz Source Type: research

[The multimorbid heart patient-an interdisciplinary challenge].
Authors: Marx N PMID: 32198541 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - March 22, 2020 Category: Cardiology Tags: Herz Source Type: research

[Hypertrophic cardiomyopathy].
Authors: Batzner A, Seggewiß H Abstract Hypertrophic cardiomyopathy is the most common genetically determined cardiac disease with a prevalence of 0.2-0.6%. The most important pathophysiological phenomenon is dynamic obstruction predominantly of the left ventricular outflow tract in 70% of the patients. Clinical symptoms (e.g. dyspnea, angina pectoris and syncope) are extremely variable depending on changes in preload and afterload and an increased risk of sudden cardiac death particularly in younger patients. The diagnostic measures should be carried out with respect to a prognostic and symptomatic trea...
Source: Herz - March 19, 2020 Category: Cardiology Tags: Herz Source Type: research

Postcardiac injury syndrome after cardiac implantable electronic device implantation.
In this study we assessed the incidence of PCIS after CIED implantation and its possible risk factors. MATERIAL AND METHODS: All patients who received CIED implantation at Heidelberg University Hospital between 2000 and 2014 were evaluated (n = 4989 patients). Clinical data including age, sex, underlying cardiac disease, type of implanted CIED, location of electrode implantation, clinical symptoms, time of symptom onset of PCIS, therapy, and outcome were extracted and analyzed. RESULTS: We identified 19 cases of PCIS in 4989 patients, yielding an incidence of 0.38%. The age of patients with PCIS range...
Source: Herz - March 15, 2020 Category: Cardiology Tags: Herz Source Type: research

Arrhythmogenic right ventricular cardiomyopathy : Evolving from unique clinical features to a  complex pathophysiological concept.
Arrhythmogenic right ventricular cardiomyopathy : Evolving from unique clinical features to a complex pathophysiological concept. Herz. 2020 Mar 13;: Authors: Paul M, Schulze-Bahr E Abstract Arrhythmogenic right ventricular cardiomyopathy (ARVC), an inherited heart muscle disease, is characterized by a progressive replacement of viable, in its classic form predominantly right ventricular myocardium by fibro-fatty tissue. These pathological alterations may provide the substrate for the occurrence of life-threatening ventricular tachyarrhythmias, heart failure, and sudden cardiac death. The cli...
Source: Herz - March 15, 2020 Category: Cardiology Tags: Herz Source Type: research

[Principles of angiology in lower extremity arterial disease (LEAD)].
Authors: Espinola-Klein C Abstract Lower extremity arterial disease (LEAD) is a frequent manifestation of atherosclerosis with a high risk for cardiovascular events. The measurement of the ankle-brachial index (ABI) should be used as a screening method for LEAD. A differentiation is made between a stable stage of intermittent claudication and the stage of critical limb ischemia. The control of cardiovascular risk factors is crucial. Particular emphasis should be placed on smoking cessation and lipid-lowering treatment with statins and a target low-density lipoprotein (LDL)-cholesterol level of
Source: Herz - March 8, 2020 Category: Cardiology Tags: Herz Source Type: research

SARS-CoV-2: a  potential novel etiology of fulminant myocarditis.
SARS-CoV-2: a potential novel etiology of fulminant myocarditis. Herz. 2020 Mar 05;: Authors: Chen C, Zhou Y, Wang DW PMID: 32140732 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - March 8, 2020 Category: Cardiology Tags: Herz Source Type: research

Incidence of permanent pacemaker implantation after valve replacement surgery : Cardiac structure and function at 1-year follow-up.
Authors: Song J, Liang Z, Wang Y, Han Z, Ren X Abstract BACKGROUND: Our study aimed to explore the incidence and risk factors of permanent pacemaker implantation (PPI) after valve replacement surgery (VR). The influence of long-term pacemaker dependency on cardiac structure and function at the 1‑year follow-up was also assessed. METHODS: The demographic and surgical data of all consecutive patients who underwent VR between 2013 and 2016 were collected. Univariate and multivariate analyses were performed to identify variables independently associated with PPI after VR. A 1‑year follow-up was undertaken of pa...
Source: Herz - March 5, 2020 Category: Cardiology Tags: Herz Source Type: research

Inflammatory dilated cardiomyopathy : Etiology and clinical management.
Authors: Maisch B, Pankuweit S Abstract Inflammatory dilated cardiomyopathy (DCMi) is a syndrome, not an etiological disease entity. The infective etiology and the immunopathology can be best determined through endomyocardial biopsy with a complete work-up by light microscopy, immunohistology, and polymerase chain reaction for microbial agents. This review focuses on the methodological advances in diagnosis in the past few years and exemplifies the importance of an etiology-orientated treatment in different case scenarios. In fulminant nonviral myocarditis, immunosuppressive treatment together with hemody...
Source: Herz - March 5, 2020 Category: Cardiology Tags: Herz Source Type: research

The risk factors of new-onset atrial fibrillation after pacemaker implantation.
Authors: Wu Z, Chen X, Ge J, Su Y Abstract OBJECTIVE: The aim of this study was to determine the incidence of newly detected atrial fibrillation (AF) in patients following dual-chamber pacemaker (PPM) implantation and to define the clinical predictors of new-onset AF in a Chinese cohort. METHODS: A total of 219 patients without documented AF that underwent dual-chamber PPM implantation for sick sinus syndrome (SSS) (n = 88) or atrioventricular block (AVB) (n = 131) were prospectively studied. All patients were invited to follow-up at 1 month, 3 months and 6 months after the...
Source: Herz - March 1, 2020 Category: Cardiology Tags: Herz Source Type: research

Amyloid cardiomyopathy.
Authors: Kristen AV Abstract Cardiac amyloidosis is a heterogeneous group of diseases characterized by extracellular deposition of amyloid fibrils in many different organs finally resulting in organ failure. Cardiac involvement is common for immunoglobulin light chain amyloidosis (AL) or transthyretin amyloidosis (ATTR); the latter is caused by a transthyretin gene variant or wild-type protein. Precise diagnostic assessment including laboratory tests, electrocardiography, echocardiography, cardiac magnetic resonance imaging, biopsy, and/or bone scintigraphy is mandatory for definition of the amyloid type ...
Source: Herz - March 1, 2020 Category: Cardiology Tags: Herz Source Type: research

Dilated cardiomyopathies and non-compaction cardiomyopathy.
Authors: Hänselmann A, Veltmann C, Bauersachs J, Berliner D Abstract Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy and one of the most common causes of heart failure. It is characterized by left or biventricular dilation and a reduced systolic function. The causes are manifold and range from myocarditis to alcohol and other toxins, to rheumatological, endocrinological, and metabolic diseases. Peripartum cardiomyopathy is a special form that occurs at the end of or shortly after pregnancy. Genetic mutations can be detected in approximately 30-50% of DCM patients. Owing to the ...
Source: Herz - March 1, 2020 Category: Cardiology Tags: Herz Source Type: research

[Gut-heart axis : How gut bacteria influence cardiovascular diseases].
Authors: Bartolomaeus H, McParland V, Wilck N Abstract The view of humans as holobionts consisting of eukaryotic host cells and associated prokaryotic organisms, has opened up a new perspective on cardiovascular pathophysiology. In particular, intestinal bacteria influence the cell and organ functions of the host. Intestinal bacteria represent a metabolically active community whose composition and function can influence cardiovascular health and disease. The interaction between the intestinal microbiota and the heart occurs via metabolites of bacterial origin, which are resorbed in the intestine and distr...
Source: Herz - February 21, 2020 Category: Cardiology Tags: Herz Source Type: research

[Novel cancer treatment and the cardiovascular risk : What should cardiologists know?]
Authors: Totzeck M, Rassaf T Abstract Cardiotoxic side effects can significantly limit the quality of life and survival of tumor patients under treatment. Acute and chronic effects include hypertension, venous and arterial thromboembolic events, acute and chronic coronary syndromes, heart failure and arrhythmias. Patients with previous cardiovascular diseases are often more frequently affected by side effects. The triggers are not only irradiation and conventional chemotherapy but increasingly also newer forms of cancer treatment. These include targeted therapy and immune checkpoint inhibitors (ICI). The goals of o...
Source: Herz - February 21, 2020 Category: Cardiology Tags: Herz Source Type: research

The bidirectional relationship between chronic obstructive pulmonary disease and coronary artery disease.
Authors: Daher A, Dreher M Abstract Chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) not only have smoking as a common risk factor, they also share epidemiological relationships and important mutual effects. There is good evidence to suggest that COPD is highly prevalent but underdiagnosed among CAD patients and vice versa. The symptoms of the two diseases can overlap, making differential diagnosis challenging. This highlights the importance of pulmonary function tests (PFTs) in patients with CAD but also a cardiological assessment in patients with COPD. Chronic obstructive p...
Source: Herz - February 14, 2020 Category: Cardiology Tags: Herz Source Type: research

Erratum zu: Prim ärprävention der koronaren Herzkrankheit : Evidenzbasierte medikamentöse Therapie.
Erratum zu: Primärprävention der koronaren Herzkrankheit : Evidenzbasierte medikamentöse Therapie. Herz. 2020 Feb 07;: Authors: Mühleck F, Laufs U PMID: 32034436 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - February 10, 2020 Category: Cardiology Tags: Herz Source Type: research

[Evidence-based primary prevention : Where do we stand in 2020?]
Authors: Schunkert H, Erbel R PMID: 32034445 [PubMed - in process] (Source: Herz)
Source: Herz - February 10, 2020 Category: Cardiology Tags: Herz Source Type: research

[Diagnostics and treatment of chronic heart failure : Update  2020].
[Diagnostics and treatment of chronic heart failure : Update 2020]. Herz. 2020 Feb 03;: Authors: Güder G, Ertl G, Angermann CE Abstract Heart failure is a systemic disease. As populations are aging worldwide, the prevalence and importance of comorbidities as major determinants of heart failure symptoms, disease progression and prognosis are increasing. Since the last version of the European Society of Cardiology guidelines for the diagnosis and treatment of heart failure was published in 2016, promising novel pharmacotherapies for chronic heart failure and its comorbidities and new devic...
Source: Herz - February 6, 2020 Category: Cardiology Tags: Herz Source Type: research

Novel approaches for the management of coronary artery disease.
Authors: Angelidis G, Valotassiou V, Kollia P, Skoularigis J, Tsougos I, Georgoulias P PMID: 32006079 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - February 3, 2020 Category: Cardiology Tags: Herz Source Type: research

[Meaningful diagnostics: imaging].
Authors: Nixdorff U Abstract Imaging of subclinical atherosclerosis is an integrated component of a preventive medicine algorithm; i.e. on the basis of a cardiovascular risk stratification patients with a low and intermediate risk qualify for further imaging (cave: Bayes' theorem). Imaging procedures for subclinical atherosclerosis have one thing in common: atherosclerosis is detected and localized directly, for which cardiac multidetector computed tomography (MDCT; coronary calcium scoring, CACS) and vascular ultrasound (carotid and/or femoral arteries) are used to measure the plaque burden. The result i...
Source: Herz - February 1, 2020 Category: Cardiology Tags: Herz Source Type: research

Left atrial appendage closure after cryoballoon ablation in patients with atrial fibrillation.
CONCLUSION: The intraprocedural combination of CBA and LAAC is feasible in patients with non-valvular AF with a high risk of stroke, TIA, and/or bleeding. Larger long-term randomized studies are needed to judge the overall safety and efficacy of the combined procedure. PMID: 32002565 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - February 1, 2020 Category: Cardiology Tags: Herz Source Type: research

[Lifestyle intervention in the primary prevention of cardiovascular diseases].
Authors: Heinicke V, Halle M Abstract Cardiovascular diseases are the leading cause of death worldwide. Adherence to a healthy lifestyle lifelong is capable of significantly reducing the cardiovascular risk by up to 70% and is therefore a key component in primary prevention of cardiovascular disease. According to the European and American guidelines lifestyle interventions include not smoking, daily physical activity of ≥150 min/week at moderate intensity or 75 min/week for higher intensity physical activity, a cardioprotective nutrition (high proportion of unsaturated fatty acids, low amounts...
Source: Herz - January 31, 2020 Category: Cardiology Tags: Herz Source Type: research

Multiallelic rare variants support an oligogenic origin of sudden cardiac death in the young.
Authors: Jaouadi H, Bouyacoub Y, Chabrak S, Kraoua L, Zaroui A, Elouej S, Nagara M, Dallali H, Delague V, Levy N, Benkhalifa R, Mechmeche R, Zaffran S, Abdelhak S Abstract Unexplained sudden death in the young is cardiovascular in most cases. Structural and conduction defects in cardiac-related genes can conspire to underlie sudden cardiac death. Here we report a clinical investigation and an extensive genetic assessment of a Tunisian family with sudden cardiac death in young members. In order to identify the family-genetic basis of sudden cardiac death, we performed Whole Exome Sequencing (WES), read dep...
Source: Herz - January 25, 2020 Category: Cardiology Tags: Herz Source Type: research

[Prevention of cardiovascular diseases in childhood and adolescence].
Authors: Goeder D, Oberhoffer R Abstract Cardiovascular diseases are among the leading causes of death worldwide. Apart from a few exceptions heart attack, stroke and peripheral arterial occlusive disease first occur in later adulthood. The cornerstone for these diseases, however, is already laid by accelerated vascular aging in childhood. Apart from pediatric medical preventive check-ups, the medical care of the parents should also be a reason for taking action. A detailed family history enables many conclusions to be drawn about the cardiovascular risk of the next generation This requires targeted diagn...
Source: Herz - January 25, 2020 Category: Cardiology Tags: Herz Source Type: research

Effects of grapeseed extract on doxorubicin-induced cardiotoxicity in rats.
CONCLUSION: Our findings suggest that GS may reduce the severity of DX-induced cardiotoxicity and thus has the potential to prevent cardiac injury in this setting. PMID: 31970462 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - January 25, 2020 Category: Cardiology Tags: Herz Source Type: research

Quality benchmarks for chest pain units and stroke units in Germany.
CONCLUSION: As reimbursement for emergency medicine in Germany was recently rearranged, quality benchmarking has gained incremental importance. Mandatory joint quality measurement in both concepts ensuring gap analysis and process improvement is encouraged. PMID: 31970463 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - January 25, 2020 Category: Cardiology Tags: Herz Source Type: research

Real-world analysis of a Biolimus A9 polymer-free drug-coated stent with very short dual antiplatelet therapy in patients at high bleeding risk.
CONCLUSION: In real-world patients at high risk of bleeding, implantation of the polymer-free metallic stent coated with Biolimus-A9 (Biofreedom®; Biosensors Europe, Morges, Switzerland) followed by 1 -month DAPT showed encouraging results without any stent thrombosis. PMID: 31965195 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - January 24, 2020 Category: Cardiology Tags: Herz Source Type: research

The TAPSE/PASP ratio and MELD score in patients with advanced heart failure.
Authors: Acar RD, Acar Ş, Doğan C, Bayram Z, Karaduman A, Uysal S, Akbal ÖY, Hakgör A, Kaymaz C, Özdemir N Abstract INTRODUCTION: The aim of this study was to explore the relationship between the tricuspid annular plane systolic excursion/pulmonary arterial systolic pressure (TAPSE/PASP) ratio and model for end-stage liver disease (MELD) score in patients with advanced heart failure. METHODS: A total of 103 patients with advanced heart failure evaluated for candidacy for heart transplantation were included in this study. TAPSE was measured by M‑mode echocardiography and cardiac catheteri...
Source: Herz - January 24, 2020 Category: Cardiology Tags: Herz Source Type: research

Cardiovascular disease in patients with chronic kidney disease.
Authors: Saritas T, Floege J Abstract Patients with chronic kidney disease (CKD) are at increased risk for kidney failure, cardiovascular disease (CVD), and death. In fact, the likelihood of dying from CVD is markedly higher than that for reaching end-stage renal disease. Evidence-based management of comorbidities such as CVD remains challenging in patients with advanced CKD, as they were usually excluded from randomized controlled trials. This review focuses on the epidemiology, risk factors, and clinical manifestations of CVD in patients with advanced CKD. Specific topics of interest include diagnostic and therap...
Source: Herz - January 17, 2020 Category: Cardiology Tags: Herz Source Type: research

[Coronary physiology in the catheter laboratory].
Authors: Baumann S, Bojara W, Post H, Rudolph T, Schäufele T, Ong P, Lehmann R, von Zur Mühlen C Abstract The regulation of coronary flow is mainly located in the resistance vessels of the microcirculation, so that the functional relevance of a coronary stenosis arises from the interaction between the epicardial stenosis and the downstream microcirculation. These complex interactions are precisely detectable by physiological measurements, such as the instantaneous wave-free ratio (iwFR) or the fractional flow reserve (FFR). In contrast, the purely visual assessment of the coronary anatomy could lead ...
Source: Herz - January 17, 2020 Category: Cardiology Tags: Herz Source Type: research

[Meaningful diagnostics: genetics].
Authors: Trenkwalder T, Schunkert H, Reinhard W Abstract Molecular genetic analysis is an important component in the diagnostics of some cardiovascular diseases; however, genetic testing should not be used as a screening technique as the diagnostic value strongly depends on anamnestic and clinical factors, such as a positive family history and the disease phenotype. In cardiovascular diseases with high mutation detection rates, e.g. hypertrophic cardiomyopathy and primary arrhythmia syndromes (long QT syndrome, catecholaminergic polymorphic ventricular tachycardia) genetic testing should be included in th...
Source: Herz - December 12, 2019 Category: Cardiology Tags: Herz Source Type: research

[Evidence-based reduction of cardiovascular risk in patients with diabetes].
Authors: Schütt KA Abstract Patients with type 2 diabetes mellitus exhibit a markedly increased propensity to develop cardiovascular diseases, such as myocardial infarction, stroke and heart failure. The results from large cardiovascular outcome trials conducted in recent years with novel hypoglycemic agents, such as dipeptidyl peptidase 4 (DPP-4) inhibitors, sodium-glucose transporter 2 (SGLT2) inhibitors and glucagon-like peptide 1 (GLP-1) receptor agonists have led to novel therapeutic strategies to reduce the cardiovascular risk in patients with diabetes. This overview article summarizes the evidence ...
Source: Herz - December 12, 2019 Category: Cardiology Tags: Herz Source Type: research

Dynamic thiol/disulphide homeostasis in patients with hypertrophic cardiomyopathy.
Authors: Sari M, Erkorkmaz U, Yazar H, Kocayigit I, Omar B, Alizade E, Aksoy MNM, Uslu A, Cakar GC, Pala S Abstract BACKGROUND: In addition to the genetic complexity of hypertrophic cardiomyopathy (HCM), there must be other disease-modifying factors that contribute to its highly variable clinical and phenotypic expression. The authors aimed to investigate serum thiol/disulphide homeostasis as a proxy for oxidative stress using a novel automated assay in patients with HCM. METHODS: This cross-sectional study was conducted on 119 patients with HCM and 52 without HCM. The methods used to measure dynamic ...
Source: Herz - December 12, 2019 Category: Cardiology Tags: Herz Source Type: research

[Primary prevention of coronary heart disease : Evidence-based drug treatment].
Authors: Mühleck F, Laufs U Abstract Coronary artery disease (CAD) is the most frequent cause of morbidity and mortality worldwide. Lifestyle modifications and drug treatment of cardiovascular risk factors are able to effectively prevent CAD. The basis of prevention is the assessment of the individual cardiovascular risk, e.g. by using a validated risk score. Documented evidence for prevention of CAD is available for the control of hypertension using angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARB) and calcium antagonists, for the treatment of hypercholesterolemia using ...
Source: Herz - December 12, 2019 Category: Cardiology Tags: Herz Source Type: research

Causes and predictors of readmission after transcatheter aortic valve implantation : A  meta-analysis and systematic review.
CONCLUSIONS: This meta-analysis found cardiovascular factors to be the main causes for both 30-day and 1‑year rehospitalization. Heart failure represented the most common cardiovascular event at both short-term and mid-term follow-up. Several baseline characteristics and procedure-related factors were deemed unfavorable predictors of readmission. Importantly, transfemoral access and female gender were associated with a lower risk of readmission. PMID: 31807789 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - December 8, 2019 Category: Cardiology Tags: Herz Source Type: research

Biomarkers in primary prevention : Meaningful diagnosis based on biomarker scores?
Authors: Schulte C, Zeller T Abstract Cardiovascular (CV) risk assessment is based on the utilization of risk scores, enabling clinicians to estimate an individual's risk to develop CV pathologies and events. Such risk scores comprise classic CV risk factors such as smoking, diabetes, hypertension, and blood cholesterol levels. Recently, other CV biomarkers such as cardiac troponins have been suggested and evaluated as alternative biomarkers not only in the acute diagnostic setting of myocardial infarction, but also as markers for risk stratification in the general population. In this review, we summarize the curre...
Source: Herz - December 8, 2019 Category: Cardiology Tags: Herz Source Type: research

Cardiac amyloidosis: in search of the ideal diagnostic tool.
CONCLUSION: NT-proBNP may be a sensitive but nonspecific biomarker for assessing CA. However, CMR is the only imaging modality that can assess the pathophysiologic background of cardiac hypertrophy and the severity of CA, irrespective of NT-proBNP level. PMID: 31796976 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - December 6, 2019 Category: Cardiology Tags: Herz Source Type: research

Effects of angiotensin receptor neprilysin inhibition on P-wave dispersion in heart failure with reduced ejection fraction.
Authors: Okutucu S, Fatihoglu SG, Sabanoglu C, Bursa N, Sayin BY, Aksoy H, Oto A Abstract BACKGROUND: Angiotensin receptor neprilysin inhibitors (ARNI; sacubitril/valsartan combination) decrease morbidity and mortality in heart failure with reduced ejection fraction (HFrEF). Increased P‑wave duration and P‑wave dispersion (Pd) reflect prolongation of atrial conduction and correlate with atrial fibrillation. Here, we aimed to assess the effects of switching from valsartan to ARNI treatment on the basis of P‑wave indices. METHODS: A total of 28 patients with HFrEF (mean age, 64.8 ±&thinsp...
Source: Herz - December 6, 2019 Category: Cardiology Tags: Herz Source Type: research

[2019 ESC guidelines: consensus in Europe for 25  years].
[2019 ESC guidelines: consensus in Europe for 25 years]. Herz. 2019 Dec;44(8):674-675 Authors: Dörr R, Maisch B PMID: 31797012 [PubMed - in process] (Source: Herz)
Source: Herz - December 6, 2019 Category: Cardiology Tags: Herz Source Type: research

Percutaneous mitral valve repair in recurrent severe mitral valve regurgitation after mitral annuloplasty : MitraClip-in-the-ring as a  complementary strategy.
CONCLUSION: MitraClip-in-the-ring is feasible and in principle safe for treating Carpentier type IIIb severe MV regurgitation after surgical MV repair using mitral annuloplasty. MitraClip-in-the-ring resulted in immediate amelioration of clinical symptoms and increased physical exercise capacity. PMID: 31773184 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - November 29, 2019 Category: Cardiology Tags: Herz Source Type: research

[New ESC guidelines 2019 for the treatment of supraventricular tachycardia].
Authors: Kuck KH, Phan HL, Tilz RR Abstract The new guidelines for the management of supraventricular tachycardia (SVT) were published by the European Society of Cardiology (ESC) in September 2019. The key message of the guidelines is that catheter ablation should be offered as a first line treatment to most patients during a comprehensive discussion of the risks and advantages. This recommendation recognizes that catheter ablation has nowadays become a widely established, effective and safe treatment method with a very low complication rate, which has revolutionized the treatment of SVT due to the substa...
Source: Herz - November 16, 2019 Category: Cardiology Tags: Herz Source Type: research

The predictive value of the epicardial adipose thickness in the rate of expansion of the aortic root.
Authors: Pourafkari L, Hassani-Afshar AO, Umholtz M, Sadeghpour A, Tajlil A, Li CM, Nader ND Abstract BACKGROUND: Epicardial adipose tissue (ECAT) is metabolically active and is involved in the development of atherosclerosis. The thickness of ECAT has been positively correlated with the dimensions of the ascending aorta. We aimed to examine whether ECAT thickness predicted the expansion of the aortic dimensions. METHODS: The imaging results of patients who had undergone transthoracic echocardiographic (TTE) examinations more than twice during the period 2005-2015 were surveyed. We included adult patients who ha...
Source: Herz - November 16, 2019 Category: Cardiology Tags: Herz Source Type: research

[ESC guidelines 2019 on chronic coronary syndrome (CCS, previously "stable coronary artery disease") : What is new? What is particularly important?]
[ESC guidelines 2019 on chronic coronary syndrome (CCS, previously "stable coronary artery disease") : What is new? What is particularly important?] Herz. 2019 Nov 11;: Authors: Silber S Abstract After an unusually long period of time of 6 years, in August 2019 the updated version of the European Society of Cardiology (ESC) guidelines from 2013 on the management of stable coronary artery disease was published. The course of "stable" coronary artery disease is only assumed to be stable and pathologically is often progressive but initially goes unnoticed. In order to raise awareness f...
Source: Herz - November 14, 2019 Category: Cardiology Tags: Herz Source Type: research

[New ESC guidelines 2019 "Diabetes, prediabetes and cardiovascular diseases" : Paradigm shift in reduction of cardiovascular risk in patients with diabetes mellitus].
[New ESC guidelines 2019 "Diabetes, prediabetes and cardiovascular diseases" : Paradigm shift in reduction of cardiovascular risk in patients with diabetes mellitus]. Herz. 2019 Nov 04;: Authors: Marx N Abstract At the last meeting of the European Society of Cardiology (ESC) in 2019 the new version of the ESC guidelines on "Diabetes, prediabetes and cardiovascular diseases", which were written in collaboration with the European Association for the Study of Diabetes (EASD), were presented. The recommendations of these guidelines included the novel evidence generated over the last 6&n...
Source: Herz - November 8, 2019 Category: Cardiology Tags: Herz Source Type: research

[ESC guidelines 2019 on diagnostics and management of acute pulmonary embolism].
This article on the new European Society of Cardiology (ESC) guidelines for diagnostics and management of acute pulmonary embolism (PE) focusses on new or changed recommendations compared to the previous version of the guidelines from 2014. The current risk-adjusted management algorithm for acute PE includes the clinical severity, aggravating comorbid conditions and right ventricular dysfunction. For low-risk patients early discharge and outpatient treatment are possible, whereas for high-risk patients reperfusion treatment and hemodynamic support have to be considered, depending on the hemodynamic situation and contraindi...
Source: Herz - November 8, 2019 Category: Cardiology Tags: Herz Source Type: research

[Obituary for Prof. Dr. med. Werner Rudolph].
Authors: Klein U PMID: 31659367 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - October 30, 2019 Category: Cardiology Tags: Herz Source Type: research

[European dyslipidemia guidelines 2019 : What is new?]
Authors: Katzmann JL, Tünnemann-Tarr A, Laufs U Abstract In August 2019 the updated dyslipidemia guidelines of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) were published. Since the last version from 2016, important large randomized trials especially with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and new genetic analyses have become available that show additional reduction of atherosclerotic cardiovascular disease (ASCVD) risk on top of the previously recommended treatments. Based on these data the main concept of the recommendations is achievin...
Source: Herz - October 29, 2019 Category: Cardiology Tags: Herz Source Type: research

[Interventional therapy of the mitral valve-an update].
Authors: Zahn R PMID: 31654183 [PubMed - in process] (Source: Herz)
Source: Herz - October 29, 2019 Category: Cardiology Tags: Herz Source Type: research

[Edge-to-edge repair : What has changed compared to the position paper in 2013?]
Authors: Boekstegers P Abstract This short review article aims to explain the changes in the treatment strategies of interventional care designed to treat secondary mitral valve regurgitation with edge-to-edge repair in comparison to the position paper published in 2013 by the German Society of Cardiology and the German Society of Thoracic and Cardiovascular Surgery. To this end the current data situation with respect to the European Society of Cardiology (ESC) guidelines from 2017, the intraprocedural assessment of mitral valve regurgitation and new technical developments are discussed. PMID: 31628494 [PubMed ...
Source: Herz - October 20, 2019 Category: Cardiology Tags: Herz Source Type: research