Risk factors associated with coronary heart disease in women: a systematic review.
Authors: Bai MF, Wang X Abstract In the context of global aging, cardiovascular disease has become the number one cause of death among Chinese women. Lifestyle factors play an important role in the development of coronary heart disease, and as awareness of the pathophysiology of coronary atherosclerosis has increased, lifestyle interventions play an important role in reducing the risk of coronary heart disease. However, there is a lack of research on the factors affecting coronary heart disease in female populations. Strengthening health education for women with coronary heart disease, reducing the burden of d...
Source: Herz - July 20, 2019 Category: Cardiology Tags: Herz Source Type: research

Pulmonary hypertension in HFpEF and HFrEF: Pathophysiology, diagnosis, treatment approaches.
Authors: Rosenkranz S, Kramer T, Gerhardt F, Opitz C, Olsson KM, Hoeper MM Abstract Pulmonary hypertension (PH) is a frequent hemodynamic condition that is highly prevalent in patients with heart failure and reduced (HFrEF) or preserved ejection fraction (HFpEF). Irrespective of left ventricular EF, the presence of PH and right ventricular (RV) dysfunction are highly relevant for morbidity and mortality in patients with heart failure. While elevated left-sided filling pressures and functional mitral regurgitation primarily lead to post-capillary PH, current guidelines and recommendations distinguish between is...
Source: Herz - July 20, 2019 Category: Cardiology Tags: Herz Source Type: research

Deactivation of cardiovascular implantable electronic devices in patients nearing end of life : Reality or only recommendation?
CONCLUSION: Many CIED patients died in hospital; nonetheless, in practice, CIED deactivation near death is rarely performed and might be less feasible in subjects with PMs. However, there is still a need to consider deactivation, especially in individuals with ICDs, as one fourth of them received at least one shock within 24 h prior to death. PMID: 31312871 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - July 18, 2019 Category: Cardiology Tags: Herz Source Type: research

Alprostadil attenuates LPS-induced cardiomyocyte injury by inhibiting the Wnt5a/JNK/NF- κB pathway.
CONCLUSION: Our results show that alprostadil has anti-inflammatory effects and could attenuate LPS-induced injury in H9c2 cardiomyocytes via the Wnt5a/JNK/NF-κB pathway. PMID: 31312872 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - July 18, 2019 Category: Cardiology Tags: Herz Source Type: research

Pulmonary hypertension and valvular heart disease.
Authors: Tichelbäcker T, Dumitrescu D, Gerhardt F, Stern D, Wissmüller M, Adam M, Schmidt T, Frerker C, Pfister R, Halbach M, Baldus S, Rosenkranz S Abstract Pulmonary hypertension (PH) is an important contributor to morbidity and mortality in patients with left-sided heart disease, including valvular heart disease. In this context, elevated left atrial pressure primarily leads to the development of post-capillary PH. Despite the fact that repair of left-sided valvular heart disease by surgical or interventional approaches will improve PH, recent studies have highlighted that PH (pre- or post-intervention...
Source: Herz - July 18, 2019 Category: Cardiology Tags: Herz Source Type: research

Management of neoplastic pericardial disease.
This study analyzed the current literature on the treatment of neoplastic pericardial effusion to provide advice and guidance for clinical treatment. Surgical treatments include pericardial puncture, extension of catheter drainage, pericardial window, and surgical pericardiotomy. Each surgical procedure has a corresponding indication, and the best treatment is selected according to the patient's specific conditions. Systemic chemotherapy is effective in lymphoma and small cell lung cancer that are sensitive to chemotherapeutic drugs. Although pericardial injection of drugs is effective for pericardial tamponade and re...
Source: Herz - July 14, 2019 Category: Cardiology Tags: Herz Source Type: research

Pulmonary and cardiac drugs: clinically relevant interactions.
Authors: Olschewski H, Canepa M, Kovacs G Abstract Chronic heart and lung diseases are very common in the elderly population. The combination of chronic heart failure and chronic obstructive pulmonary disease (COPD) is also common and, according to current guidelines, these patients should be treated for both diseases. In patients with heart failure, beta-blockers are very important drugs because their use is associated with significantly improved morbidity and mortality. These beneficial effects were documented in patients with and without COPD, although theoretically there is a risk for bronchoconstriction, parti...
Source: Herz - July 14, 2019 Category: Cardiology Tags: Herz Source Type: research

Plasma osteopontin levels, but not its myocardial expression, reflect heart failure severity in recently diagnosed dilated cardiomyopathy.
CONCLUSION: Plasma OPN levels reflect heart failure severity in patients with Ro-DCM. Myocardial OPN expression is not associated with either plasma OPN levels or markers of heart failure in these individuals. PMID: 31289910 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - July 13, 2019 Category: Cardiology Tags: Herz Source Type: research

[Medical care of adults with congenital heart diseases : Present and future].
Authors: Neidenbach R, Achenbach S, Andonian C, Beckmann J, Biber S, Dittrich S, Ewert P, Freilinger S, Huntgeburth M, Nagdyman N, Oberhoffer R, Pieper L, von Kodolitsch Y, Weyand M, Bauer UMM, Kaemmerer H Abstract Congenital heart diseases (CHD) are the most common types of congenital organ defects. Thanks to medical progress in congenital cardiology and heart surgery, most children with CHD reach adulthood. Despite primarily successful treatment residual and subsequent conditions as well as (non)cardiac comorbidities can influence the chronic course of the disease and lead to a higher morbidity and mortality. Adu...
Source: Herz - July 4, 2019 Category: Cardiology Tags: Herz Source Type: research

Ectopic origin and communicating branch of left anterior descending artery arising from the conus artery: a  rare coronary anomaly.
Ectopic origin and communicating branch of left anterior descending artery arising from the conus artery: a rare coronary anomaly. Herz. 2019 Jun 28;: Authors: Shan X, Yu M, Zhao X PMID: 31254012 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - July 1, 2019 Category: Cardiology Tags: Herz Source Type: research

[Cardiac involvement in storage diseases : Role of genetic diagnostics].
Authors: Trenkwalder T, Schunkert H, Reinhard W Abstract In clinical practice cardiac involvement in patients with storage disorders is often diagnosed at a late and advanced stage of the disease with pronounced organ damage. As the currently available targeted therapies can only stop the progress of the disease, a timely diagnosis is of particular relevance. Genetic testing has become increasingly more important in cases of suspected cardiac manifestation in storage disorders. Thereby, diagnostic genetic testing can help to confirm the diagnosis and may also be relevant for therapeutic decision making. In rel...
Source: Herz - June 28, 2019 Category: Cardiology Tags: Herz Source Type: research

Effect of novel oral anticoagulants on Hospital Anxiety and Depression Scale scores.
Authors: Cosansu K, Ureyen CM, Yılmaz S Abstract BACKGROUND: The negative impact of atrial fibrillation (AF) on health-related quality of life has been extensively documented. The aim of this study was to compare the Hospital Anxiety and Depression Scale (HADS) scores of patients with non-valvular AF during warfarin administration and after switching to novel oral anticoagulants (NOACs). METHODS: The study comprised 100 consecutive patients on warfarin treatment between July 2018 and January 2019 for whom a transition to NOACs was planned. All patients completed the HADS at the start of the study and at l...
Source: Herz - June 28, 2019 Category: Cardiology Tags: Herz Source Type: research

[Evidence-based drug therapy for heart failure-an update].
Authors: Emrich IE, Wintrich J, Kindermann I, Böhm M Abstract Chronic heart failure affects millions of people worldwide and is associated with high morbidity and mortality. Because of steadily increasing ageing populations and improved survival rates after myocardial infarction, the incidence of chronic heart failure is rising. As acute decompensated heart failure is one of the leading causes for hospitalization in Germany, heart failure imposes a huge economic burden on its health care system. Guideline directed therapy is important to improve prognosis. In the following, we give an overview about novel...
Source: Herz - June 28, 2019 Category: Cardiology Tags: Herz Source Type: research

Prognostic value  of lipid levels in short-term outcome after TAVI.
CONCLUSION: This study suggests that lower serum LDL-C and HDL-C levels are independently associated with short-term MACCE in post-TAVI patients. Lower levels of LDL and HDL cholesterol may indicate a poor prognosis. Measurement of serum lipid levels might improve the preoperative risk assessment of potential TAVI candidates. PMID: 31209519 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - June 20, 2019 Category: Cardiology Tags: Herz Source Type: research

Everolimus- vs. novolimus-eluting bioresorbable scaffolds in patients with acute coronary syndrome.
CONCLUSION: In this study, similar 12-month event rates were observed for both BRS types after implantation for the treatment of ACS. PMID: 31209520 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - June 20, 2019 Category: Cardiology Tags: Herz Source Type: research

Prevalence of TTN mutations in  patients with dilated cardiomyopathy : A meta-analysis.
Prevalence of TTN mutations in patients with dilated cardiomyopathy : A meta-analysis. Herz. 2019 Jun 17;: Authors: Fang HJ, Liu BP Abstract A meta-analysis was performed to assess the prevalence of TTN mutations in patients with dilated cardiomyopathy (DCM). Prevalence point estimates and 95% confidence intervals were computed using the logit transformation formula. The prevalence of TTN mutations in patient with DCM, familial dilated cardiomyopathy (FDCM), and sporadic dilated cardiomyopathy (SDCM) was 0.17 (95% CI: 0.14-0.19), 0.23 (95% CI: 0.20-0.26), and 0.16 (95%&nbs...
Source: Herz - June 20, 2019 Category: Cardiology Tags: Herz Source Type: research

Effect of typhaneoside on ventricular remodeling and regulation of PI3K/Akt/mTOR pathway.
CONCLUSION: Typhaneoside regulates IL-6 and TNF-α as well as MMP-2 and MMP-9 in rats with heart failure after myocardial infarction. Typhaneoside can improve cardiac morphological structure and myocardial remodeling and enhance heart function. It may mediate autophagy inhibition in the cardiomyocyte anoxia/reoxygenation (A/R) pathway through the PI3K/Akt/mTOR autophagy transduction pathway. PMID: 31201434 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - June 17, 2019 Category: Cardiology Tags: Herz Source Type: research

Left heart function in COPD : Impact of lung deflation.
Authors: Struß N, Bauersachs J, Welte T, Hohlfeld JM Abstract Chronic obstructive pulmonary disease (COPD) primarily affects the lungs; however, cardiovascular conditions are among the most common extrapulmonary comorbidities. Besides shared risk factors such as cigarette smoking, pathophysiological connections between the lung and the heart have been identified as mediators of reduced cardiac output. Recent research has focused on hyperinflation of the lung as a pulmonary cause for heart dysfunction. Hyperinflation is a typical lung abnormality seen in COPD; it is characterized by increased residua...
Source: Herz - June 14, 2019 Category: Cardiology Tags: Herz Source Type: research

Prognosis of patients with previous myocardial infarction, coronary slow flow, and normal coronary angiogram.
CONCLUSION: In patients with CSF and an otherwise normal coronary angiogram, a history of a previous MI is associated with unfavorable long-term outcomes. PMID: 31187194 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - June 14, 2019 Category: Cardiology Tags: Herz Source Type: research

[Effect of humor training on stress, cheerfulness and depression in patients with coronary artery disease and refractory angina pectoris].
CONCLUSION: Patients with refractory angina pectoris and stable CAD benefit from a professional humor coaching. This effect was shown in a) a significant decrease in cortisol concentrations in the hair segment analysis, b) an improvement in cheerfulness in the STCI and c) a significant difference in the BDI between pre-post values. PMID: 31187195 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - June 14, 2019 Category: Cardiology Tags: Herz Source Type: research

Erratum to: Stroke in patients with prosthetic valve endocarditis : Single-center cohort study in China.
Authors: Cao GF, Liu W, Cao L, Wang Y Abstract Erratum to: Herz 2019 https://doi.org/10.1007/s00059-019-4809-4 The original article has been corrected. The data given in Table 4 for patient No. 13 were wrong. Please find here the corrected Table.The authors and publisher apologize for this …. PMID: 31139843 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - May 31, 2019 Category: Cardiology Tags: Herz Source Type: research

COPD and heart failure: differential diagnosis and comorbidity.
Authors: Güder G, Störk S Abstract Heart failure (HF) and chronic obstructive pulmonary disease (COPD) represent the most important differential diagnoses of dyspnea in elderly people. Heart failure is the inability of the heart to pump sufficient amounts of blood through the cardiovascular system. Pump failure is caused by compromised contractility and/or filling of the ventricles leading to forward and backward failure and subsequently to dyspnea. In COPD, the destruction and remodeling processes of the bronchiolar architecture inhibit proper exhalation of air, thereby leading to exhaustion of the thora...
Source: Herz - May 22, 2019 Category: Cardiology Tags: Herz Source Type: research

Right ventricular function in  pulmonary (arterial) hypertension.
Right ventricular function in pulmonary (arterial) hypertension. Herz. 2019 May 17;: Authors: Tello K, Gall H, Richter M, Ghofrani A, Schermuly R Abstract The right ventricle (RV) is the main determinant of prognosis in pulmonary hypertension. Adaptation and maladaptation of the RV are of crucial importance. In the course of disease, RV contractility increases through changes in muscle properties and muscle hypertrophy. At a certain point, the point of "uncoupling," the afterload exceeds contractility, and maladaptation as well as dilation occurs to maintain stroke volume (SV). To u...
Source: Herz - May 19, 2019 Category: Cardiology Tags: Herz Source Type: research

[Oral anticoagulation and antiplatelet therapy in patients with atrial fibrillation after coronary interventions].
This article reviews the current data from studies testing strategies with NOACs plus one or two antiplatelet substances in comparison to triple therapy with VKA. PMID: 31087108 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - May 17, 2019 Category: Cardiology Tags: Herz Source Type: research

Pericardial complications and postcardiac injury syndrome after cardiovascular implantable electronic device placement : A  meta-analysis and systematic review.
CONCLUSION: Our analysis revealed that CIED implantations are associated with a low incidence (0.6%) of pericardial complications at 30 days. Patients with advanced age and prior CABG are high-risk patients for pericardial complications. PMID: 31076821 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - May 12, 2019 Category: Cardiology Tags: Herz Source Type: research

Stroke in patients with prosthetic valve endocarditis : Single-center cohort study in China.
CONCLUSION: Stroke is a common complication in PVE that increases patient mortality. Rheumatic heart disease, double valve replacement, and fungal infection may be risk factors for patients with PVE complicated by stroke. PMID: 31076822 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - May 12, 2019 Category: Cardiology Tags: Herz Source Type: research

[Left atrial appendage closure in non-valvular atrial fibrillation].
Authors: Häusler KG, Landmesser U Abstract Atrial fibrillation is the most frequent cardiac arrhythmia worldwide, causing approximately 20% of all ischemic strokes. Therefore, oral anticoagulation is recommended in patients with atrial fibrillation with at least a moderate risk of stroke; however, there is a significant proportion of patients who cannot undergo long-term oral anticoagulation. As the left atrial appendage is of major relevance for atrial fibrillation-induced thrombus formation, catheter-based or surgical closure of the left atrial appendage appears to be a promising therapeutic option...
Source: Herz - May 12, 2019 Category: Cardiology Tags: Herz Source Type: research

[Embolic stroke of undetermined source (ESUS) : How much monitoring is necessary?]
Authors: Stegmann T, Wachter R, Schäbitz WR Abstract The clinical construct of embolic stroke of unknown source (ESUS) was first described in 2014. It is defined as cryptogenic ischemic stroke after the exclusion of a lacunar infarct, a significant (≥50%) stenosis of extracranial or intracranial arteries and a cardiac source of embolism. Initially, there was hope that these patients would benefit from anticoagulation. This was based on the suspicion that imaging criteria of stroke mimic features of embolism from cardiac sources or the great arteries. In two large randomized trials with 12,600 patients neith...
Source: Herz - May 9, 2019 Category: Cardiology Tags: Herz Source Type: research

[Heart failure and diabetes-underestimated, poorly understood and too rarely diagnosed].
Authors: Marx N, Dörr R, Tschöpe D PMID: 31053890 [PubMed - in process] (Source: Herz)
Source: Herz - May 7, 2019 Category: Cardiology Tags: Herz Source Type: research

QTc interval prolongation during recovery from brief high-intensity intermittent exercise in obese adults.
This study investigated heart rate-corrected QT interval (QTc) dynamics during recovery from HIE in obese adults. In total, 13 obese males (age: 24.3 ± 4.6 years old; body mass index: 31.6 ± 4.1 kg/m2) underwent: (1) HIE: an HIE session of four 30-s all-out cycling efforts interspersed with 4‑min recovery periods; (2) REC: a recovery session 24 h after HIE; and (3) CON: a control session of no treatment. The QT interval was measured before HIE, REC, and CON, and then at 30-min intervals thereafter, for up to 3 h. QTc values were obtained using Bazett, Fr...
Source: Herz - May 2, 2019 Category: Cardiology Tags: Herz Source Type: research

[Heart and brain-two terms, one central problem : The stroke].
Authors: Erbel R, Diener HC PMID: 31041491 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - May 2, 2019 Category: Cardiology Tags: Herz Source Type: research

Associations between nine candidate genetic polymorphisms with coronary heart disease : A  meta-analysis.
CONCLUSION: Our results show that the susceptibility to CHD was associated with three polymorphisms: PON1 -108C/T, hOGG1 +1245C/G, and SCARB1 +1050C/T. PMID: 31041492 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - May 2, 2019 Category: Cardiology Tags: Herz Source Type: research

[Echocardiographic emergency diagnostics].
This article summarizes the currently valid recommendations on emergency echocardiography of the German Cardiac Society and the European Association of Cardiovascular Imaging and provides practical guidance for their implementation in emergency medicine. Echocardiography is especially important for the diagnostics of acute coronary syndrome and its potential complications, of pulmonary embolism and endocarditis as well as the differential diagnosis of patients in shock and in emergencies. A domain of increasing importance in echocardiography is the treatment monitoring of patients supported by modern cardiac assist de...
Source: Herz - April 27, 2019 Category: Cardiology Tags: Herz Source Type: research

Erratum zu: Warum brauchen wir Cardiac-Arrest-Zentren?
Authors: Scholz KH, Böttiger BW PMID: 30993358 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - April 19, 2019 Category: Cardiology Tags: Herz Source Type: research

[Closure of the patent foramen ovale (PFO) in cryptogenic stroke].
Authors: Diener HC, Knebel F Abstract Autopsy studies and echocardiographic investigations have shown that around 20-25% of the healthy population have a patent foramen ovale (PFO). In patients younger than 55 years the risk of a cryptogenic stroke is increased in the presence of a PFO. The first three randomized studies could not demonstrate superiority of an interventional closure of a PFO compared to antithrombotic treatment in patients with cryptogenic stroke. The results of three recently published studies and the extension of an earlier study showed a superiority of an interventional closu...
Source: Herz - April 5, 2019 Category: Cardiology Tags: Herz Source Type: research

[New aspects of thrombolysis and thrombectomy in pulmonary embolism].
This article discusses these procedures in the light of the currently available literature. PMID: 30941473 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - April 5, 2019 Category: Cardiology Tags: Herz Source Type: research

[Management of oral anticoagulation related intracerebral hemorrhage].
Authors: Sembill JA, Kuramatsu JB, Hohnloser SH, Huttner HB Abstract The incidence of intracerebral hemorrhage (ICH) in patients using oral anticoagulation (OAC) will continue to increase with the demographic change of an aging population. As compared to primary spontaneous ICH, OAC-ICH is characterized by larger hematoma volumes, more frequent hematoma enlargement and intraventricular hemorrhage resulting in an even worse prognosis. Specific treatment should focus on immediate reversal of anticoagulation in addition to the basic acute management of ICH. In ICH patients using vitamin K antagonists (V...
Source: Herz - April 5, 2019 Category: Cardiology Tags: Herz Source Type: research

Cardiac imaging after ischemic stroke : Echocardiography, CT, or MRI?
Authors: Camen S, Haeusler KG, Schnabel RB Abstract About 20-25% of all ischemic strokes are of cardioembolic etiology, with atrial fibrillation and heart failure as the most common underlying pathologies. Diagnostic work-up by noninvasive cardiac imaging is essential since it may lead to changes in therapy, e.g., in-but not exclusively-secondary stroke prevention. Echocardiography remains the cornerstone of cardiac imaging after ischemic stroke, with the combination of transthoracic and transesophageal echocardiography as gold standard thanks to their high sensitivity for many common pathologies. Transesophageal e...
Source: Herz - April 5, 2019 Category: Cardiology Tags: Herz Source Type: research

[Immunization as Treatment for arteriosclerosis-a  realistic vision?]
[Immunization as Treatment for arteriosclerosis-a realistic vision?] Herz. 2019 Apr;44(2):93-95 Authors: Winkels H, Baldus S PMID: 30923854 [PubMed - in process] (Source: Herz)
Source: Herz - March 30, 2019 Category: Cardiology Tags: Herz Source Type: research

Congestive heart failure caused by silent ischemia and silent myocardial infarction : Diagnostic challenge in type  2 diabetes.
Congestive heart failure caused by silent ischemia and silent myocardial infarction : Diagnostic challenge in type 2 diabetes. Herz. 2019 Mar 21;: Authors: Valensi P, Meune C Abstract In asymptomatic patients with type 2 diabetes (T2D), the prevalence of silent myocardial infarction on routine electrocardiograms is about 4% while for silent myocardial ischemia it is 20-30%. Some studies showed that silent myocardial infarction is associated with an increased risk of incident heart failure (HF), whereas no prospective study has ever reported such a risk in patients with silent myocardial ...
Source: Herz - March 23, 2019 Category: Cardiology Tags: Herz Source Type: research

[Immunity and inflammation in atherosclerosis].
This article summarizes and discusses the pathogenesis of arteriosclerosis with a focus on the role of the adaptive immune system. Some limitations of animal models are discussed and the need for models that are tailored to better translate to human atherosclerosis and ultimately progress in prevention and treatment are emphasized. PMID: 30859253 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - March 13, 2019 Category: Cardiology Tags: Herz Source Type: research

[Microbiome, diabetes and heart: a  novel link?]
[Microbiome, diabetes and heart: a novel link?] Herz. 2019 Mar 07;: Authors: Kappel BA, Lehrke M Abstract Patients with type 2 diabetes suffer from a high cardiovascular risk. The underlying pathomechanisms are not fully understood and treatment options are correspondingly limited. The gut microbiome could be a new important player in cardiometabolic diseases. Dysbiosis of the intestinal flora has been associated with insulin resistance, diabetes mellitus and cardiovascular diseases, such as atherosclerosis and heart failure. The negative cardiovascular effects of type 2 diabetes me...
Source: Herz - March 9, 2019 Category: Cardiology Tags: Herz Source Type: research

Heart failure and diabetes: management and open issues.
This article summarizes important aspects of the association between diabetes mellitus and heart failure. PMID: 30847507 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - March 9, 2019 Category: Cardiology Tags: Herz Source Type: research

Catheter ablation in atrial fibrillation: is there a  mortality benefit in patients with diabetes and heart failure?
Catheter ablation in atrial fibrillation: is there a mortality benefit in patients with diabetes and heart failure? Herz. 2019 Mar 07;: Authors: Matta M, Saglietto A, De Salvo P, Bissolino A, Ballatore A, Anselmino M Abstract Atrial fibrillation (AF) is the most commonly sustained arrhythmia, and patients with diabetes mellitus (DM) exhibit an increased incidence of AF. Besides DM, heart failure (HF) shares pathophysiological links with AF, mainly related to the pathological remodeling of hearts affected by structural disease. As in a vicious circle, AF may contribute to HF worsening and incr...
Source: Herz - March 9, 2019 Category: Cardiology Tags: Herz Source Type: research

[Blood pressure targets in patients with diabetes mellitus : What are optimum values?]
Authors: Dederer J, Bewarder Y, Mahfoud F, Böhm M Abstract Diabetes mellitus and arterial hypertension are the most prevalent diseases in the aging population. Both are important risk factors for the development of cardiovascular complications and are associated with a high mortality. Both diseases are often first recognized late. The prognosis of patients with diabetes mellitus is favorably influenced by an optimal adjustment of blood sugar and blood pressure, as confirmed in large randomized clinical trials. Patients with diabetes mellitus and a blood pressure>130/80 mm Hg should first receive li...
Source: Herz - March 9, 2019 Category: Cardiology Tags: Herz Source Type: research

Key inflammatory pathways underlying vascular remodeling in pulmonary hypertension.
Authors: Berghausen EM, Feik L, Zierden M, Vantler M, Rosenkranz S Abstract Independent of the underlying cause, pulmonary hypertension (PH) remains a devastating condition that is characterized by limited survival. Cumulating evidence indicates that in addition to a dysbalance of mediators regulating vascular tone and growth factors promoting vascular remodeling, failure to resolve inflammation and altered immune processes play a pivotal role in the development and progression of PH. Here, we highlight the role of key inflammatory pathways in the pathobiology of vascular remodeling and PH, and discu...
Source: Herz - March 9, 2019 Category: Cardiology Tags: Herz Source Type: research

[Curing cancer and protecting the heart : Challenges in cardio-oncology in the era of modern tumor treatment].
This article provides an overview and comprehensive summary of the possible cardiotoxic side effects of important oncological therapies and offers possible practical strategies with respect to risk stratification, cardiological follow-up care and management approaches for chemotherapy-induced left ventricular dysfunction. PMID: 30847511 [PubMed - as supplied by publisher] (Source: Herz)
Source: Herz - March 9, 2019 Category: Cardiology Tags: Herz Source Type: research

Clinical implications of cardiovascular outcome trials in type  2 diabetes.
Clinical implications of cardiovascular outcome trials in type 2 diabetes. Herz. 2019 Feb 25;: Authors: Mellbin LG, Wang A, Rydén L Abstract Cardiovascular disease (CVD) is the main reason for premature death in patients with type 2 diabetes. Hyperglycemia, the hallmark of diabetes, has long been considered the link between diabetes and CVD, and many trials focused on preventing CVD manifestations by means of tight glucose control. However, diabetes is a multifactorial disease in which, e. g., insulin resistance, endothelial dysfunction, and factors such as hypertensio...
Source: Herz - February 27, 2019 Category: Cardiology Tags: Herz Source Type: research

Inflammation in thoracic aortic aneurysms.
Authors: Dinesh NEH, Reinhardt DP Abstract Mutations in extracellular matrix and smooth muscle cell contractile proteins predispose to thoracic aortic aneurysms in Marfan syndrome (MFS) and related disorders. These genetic alterations lead to a compromised extracellular matrix-smooth muscle cell contractile unit. The abnormal aortic tissue responds with defective mechanosensing under hemodynamic stress. Aberrant mechanosensing is associated with transforming growth factor-beta (TGF-β) hyperactivity, enhanced angiotensin-II (Ang-II) signaling, and perturbation of other cellular signaling pathways. The down...
Source: Herz - February 13, 2019 Category: Cardiology Tags: Herz Source Type: research

Critical inflammatory mechanisms underlying arrhythmias.
Authors: Vonderlin N, Siebermair J, Kaya E, Köhler M, Rassaf T, Wakili R Abstract During the past few decades, cardiovascular research has increasingly focused on systemic inflammatory mechanisms, particularly in the field of atherosclerosis but also in association with cardiac arrhythmogenesis. Objective inflammatory markers including C‑reactive protein and cytokines, also called "biomarkers," seem to serve as predictors of onset and prognosis of cardiac arrhythmias. This review gives an overview of potential mechanisms underlying inflammatory processes and arrhythmias, especially atrial fibrillat...
Source: Herz - February 9, 2019 Category: Cardiology Tags: Herz Source Type: research