Corrigendum to "Intensive lifestyle modifications with or without liraglutide 3mg vs. sleeve gastrectomy: A three-arm non-randomised, controlled, pilot study" [Diabetes Metab. 44 (2018) 235-242].
Corrigendum to "Intensive lifestyle modifications with or without liraglutide 3mg vs. sleeve gastrectomy: A three-arm non-randomised, controlled, pilot study" [Diabetes Metab. 44 (2018) 235-242]. Diabetes Metab. 2019 Mar 08;: Authors: Capristo E, Panunzi S, De Gaetano A, Raffaelli M, Guidone C, Iaconelli A, L'Abbate L, Birkenfeld AL, Bellantone R, Bornstein S, Mingrone G PMID: 30857948 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - March 8, 2019 Category: Endocrinology Authors: Capristo E, Panunzi S, De Gaetano A, Raffaelli M, Guidone C, Iaconelli A, L'Abbate L, Birkenfeld AL, Bellantone R, Bornstein S, Mingrone G Tags: Diabetes Metab Source Type: research

Obesity paradox in associations between body mass index and diabetes-related hospitalization and mortality in patients with type 2 diabetes: Retrospective cohort studies.
CONCLUSIONS: - The BMI associated with the best survival and less hospitalization was the higher-high-risk obesity (≥ 27.5 kg/m2) category. We observed obesity paradox for mortality outcomes, which should be addressed by further research, particularly on whether randomized controlled trials of adopting a healthy lifestyle for patients with obesity can improve type 2 diabetes patients' survival. PMID: 30858146 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - March 8, 2019 Category: Endocrinology Authors: Lin CC, Li CI, Liu CS, Lin WY, Lin CH, Chiang JI, Yang SY, Li TC Tags: Diabetes Metab Source Type: research

Role of myokines in the development of skeletal muscle insulin resistance and related metabolic defects in type 2 diabetes.
Abstract Due to its mass, skeletal muscle is the major site of glucose uptake and an important tissue in the development of type 2 diabetes (T2D). Muscles of patients with T2D are affected with insulin resistance and mitochondrial dysfunction, which results in impaired glucose and fatty acid metabolism. A well-established method of managing the muscle metabolic defects occurring in T2D is physical exercise. During exercise, muscles contract and secrete factors called myokines which can act in an autocrine/paracrine fashion to improve muscle energy metabolism. In patients with T2D, plasma levels as well as muscle l...
Source: Diabetes and Metabolism - March 4, 2019 Category: Endocrinology Authors: Garneau L, Aguer C Tags: Diabetes Metab Source Type: research

Association between increased carotid intima-media thickness, higher serum levels of C-terminal telopeptide of typecollagen in postmenopausal women with type I 2, diabetes.
PMID: 30844448 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - March 4, 2019 Category: Endocrinology Authors: Mantovani A, Altomari A, Fassio A, Gatti D, Bonnet F, Targher G Tags: Diabetes Metab Source Type: research

Links between aldosterone excess and metabolic complications: a comprehensive review.
Abstract Shortly after the first description of primary aldosteronism (PA) appeared in the 1950s by Jerome Conn, an association of the condition with diabetes mellitus was documented. However, a clear pathophysiological interrelationship linking the two entities has yet to be established. Nevertheless, so far, many mechanisms contributing to insulin resistance and dysregulation of glucose uptake have been described. At the same time, many observational studies have reported an increased prevalence of the metabolic syndrome (MetS) among patients with PA. Regarding the relationship between aldosterone levels and obe...
Source: Diabetes and Metabolism - February 27, 2019 Category: Endocrinology Authors: Bothou C, Beuschlein F, Spyroglou A Tags: Diabetes Metab Source Type: research

Glycaemic variability and hypoglycaemia are associated with C-peptide levels in insulin-treated type 2 diabetes.
h;rgaard K Abstract AIM: - The aim of the study was to evaluate the association between C-peptide levels, glycaemic variability and hypoglycaemia in patients with insulin-treated type 2 diabetes (T2D). METHODS: - A total of 98 patients with T2D treated with basal-bolus insulin were enrolled in a cross-sectional study. Glycaemic variability and hypoglycaemia were assessed from continuous glucose monitoring (CGM) data recorded over 6 days: the former was assessed by calculating the mean coefficient of variation (CV), while the latter was defined as sensor glucose levels ≤ 3.9 mmol/L or
Source: Diabetes and Metabolism - February 20, 2019 Category: Endocrinology Authors: Christensen MB, Gæde P, Hommel E, Gotfredsen A, Nørgaard K Tags: Diabetes Metab Source Type: research

Spontaneous and iatrogenic hypoglycaemia related to mortality in the ICU.
Abstract AIM: - Our study investigated the relationship between both spontaneous and iatrogenic hypoglycaemia and mortality. METHODS: - A total of 200,859 patients from the eICU Collaborative Research Database were grouped by whether they had registered episodes of hypoglycaemia or not. Patients with hypoglycaemia were then further divided into subgroups according to type of hypoglycaemia-whether spontaneous or iatrogenic. Spontaneous hypoglycaemia during an ICU stay was defined as one or more registered blood glucose measurements
Source: Diabetes and Metabolism - February 15, 2019 Category: Endocrinology Authors: Cichosz SL, Redke F, Hejlesen OK Tags: Diabetes Metab Source Type: research

Association betweenPNPLA3rs738409, polymorphism, decreased kidney function in postmenopausal type 2, diabetic women with or without non-alcoholic fatty liver disease.
Abstract AIM: - Evidence is emerging that PNPLA3 rs738409 polymorphism (the major genetic variant associated with susceptibility to non-alcoholic fatty liver disease [NAFLD]) is associated with chronic kidney disease (CKD) in non-diabetic individuals. Currently, little is known about this association in type 2 diabetic (T2DM) patients with and without NAFLD. METHODS: - We studied 101 Caucasian post-menopausal women with T2DM, consecutively attending our diabetes outpatient service during a 3-month period. Glomerular filtration rate (eGFRCKD-EPI) was estimated using the CKD-Epidemiology Collaboration equation,...
Source: Diabetes and Metabolism - February 11, 2019 Category: Endocrinology Authors: Mantovani A, Zusi C, Sani E, Colecchia A, Lippi G, Zaza G, Valenti L, Byrne CD, Maffeis C, Bonora E, Targher G Tags: Diabetes Metab Source Type: research

Glycaemic variability is associated with severity of coronary artery disease in patients with poorly controlled type 2 diabetes and acute myocardial infarction.
tin Y Abstract BACKGROUND: - In patients with type 2 diabetes (T2D), glycaemic variability (GV), another component of glycaemic abnormalities, is a novel potentially aggravating factor for coronary artery disease (CAD). OBJECTIVES: - The aim of our study was to identify interactions between GV and severity of CAD in diabetes patients admitted for acute myocardial infarction (AMI). METHODS: - All patients with T2D admitted to our university hospital for AMI from March 2015 to February 2017 who received intravenous (IV) insulin therapy and underwent coronary angiography were included. GV was assessed by me...
Source: Diabetes and Metabolism - February 11, 2019 Category: Endocrinology Authors: Benalia M, Zeller M, Mouhat B, Guenancia C, Yameogo V, Greco C, Yao H, Maza M, Vergès B, Cottin Y Tags: Diabetes Metab Source Type: research

Risk of bone fracture associated with sodium-glucose cotransporter-2 inhibitor treatment: a meta-analysis of randomized controlled trials.
CONCLUSION: Our meta-analysis has indicated that SGLT2 inhibitors do not increase risk of bone fracture compared with placebo in patients with T2DM. However, these findings now need to be confirmed in well-designed RCT studies. PMID: 30738154 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - February 6, 2019 Category: Endocrinology Authors: Cheng L, Li YY, Wen H, Bai F, Hao HR, Yu WN, Mao XM Tags: Diabetes Metab Source Type: research

Musculoskeletal disorders in patients with type 1 diabetes: an understudied group of diabetes complications that deserves further investigation.
PMID: 30711648 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - January 31, 2019 Category: Endocrinology Authors: Picard S, Vasilevski D, Fagherazzi G Tags: Diabetes Metab Source Type: research

Beneficial effects of SGLT2 inhibitors on fatty liver in type 2 diabetes: a common comorbidity associated with severe complications.
Abstract Patients with type 2 diabetes mellitus (T2DM) are exposed to non-alcoholic fatty liver disease (NAFLD), a comorbidity associated with cardiovascular disease and chronic kidney disease, and which may progress to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Sodium-glucose cotransporter type-2 (SGLT2) inhibitors are glucose-lowering agents that improve glucose control while promoting weight loss and lowering serum uric acid levels. These agents may exert cardiovascular and renal protection in T2DM patients with established cardiovascular disease. Recent findings from both randomized controll...
Source: Diabetes and Metabolism - January 29, 2019 Category: Endocrinology Authors: Scheen AJ Tags: Diabetes Metab Source Type: research

Glucocentric risk factors for macrovascular complications in diabetes: Glucose 'legacy' and 'variability'-what we see, know and try to comprehend.
Abstract Recognizing the role of dysglycaemia, 'ambient' hyperglycaemia, 'metabolic memory' and glycaemic variability as risk factors for macrovascular diseases is mandatory for effective diabetes management. Chronic hyperglycaemia, also referred to as 'ambient hyperglycaemia', was only fully acknowledged as a risk factor for adverse cardiovascular events when the beneficial effects of intensive glucose-lowering strategies were consolidated in the extended follow-up (> 10 years) of patients included in the United Kingdom Prospective Diabetes Study (UKPDS) and Diabetes Control and Complications Trial (DCCT)/Epid...
Source: Diabetes and Metabolism - January 24, 2019 Category: Endocrinology Authors: Monnier L, Colette C, Schlienger JL, Bauduceau B, R Owens D Tags: Diabetes Metab Source Type: research

Efficacy and adherence of glucagon-like peptide-1 receptor agonist treatment in patients with type 2 diabetes mellitus in real-life settings.
e;s B Abstract Despite the availability of a large number of therapeutic options throughout the world, rates of optimal glycaemic control in adult patients with type 2 diabetes mellitus remain low. Delays in treatment intensification to insulin and low adherence to insulin regimes, which are well-documented contributors to poor glycaemic control, are in many cases driven by fear of hypoglycaemic events, weight gain and injections. Over the last 10 years, injectable glucagon-like peptide-1 receptor agonists (GLP1-RAs) have emerged as alternatives to basal insulin for treatment intensification in patients inadequate...
Source: Diabetes and Metabolism - January 21, 2019 Category: Endocrinology Authors: Guerci B, Charbonnel B, Gourdy P, Hadjadj S, Hanaire H, Marre M, Vergès B Tags: Diabetes Metab Source Type: research

Severely uncontrolled diabetes: a new aetiology of acquired bisalbuminaemia.
PMID: 30660760 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - January 17, 2019 Category: Endocrinology Authors: Lugat A, Caillon H, Chaillous L, Cariou B, Drui D Tags: Diabetes Metab Source Type: research

Insulin resistance and NAFLD: relationship with intrahepatic iron and serum TNF- α using 1H MR spectroscopy and MRI.
Insulin resistance and NAFLD: relationship with intrahepatic iron and serum TNF-α using 1H MR spectroscopy and MRI. Diabetes Metab. 2019 Jan 17;: Authors: Martin-Rodriguez JL, Gonzalez-Cantero J, Gonzalez-Cantero A, Martí-Bonmatí L, Alberich-Bayarri Á, Gonzalez-Cejudo T, Gonzalez-Calvin JL Abstract AIM: The association of non-alcoholic fatty liver disease (NAFLD) with insulin resistance (IR) is well established, yet little is known of their possible relationship with intrahepatic iron and serum tumour necrosis factor (TNF)-α concentrations in adults without diabetes. T...
Source: Diabetes and Metabolism - January 17, 2019 Category: Endocrinology Authors: Martin-Rodriguez JL, Gonzalez-Cantero J, Gonzalez-Cantero A, Martí-Bonmatí L, Alberich-Bayarri Á, Gonzalez-Cejudo T, Gonzalez-Calvin JL Tags: Diabetes Metab Source Type: research

Glucagon-like peptide-1 promotes α-to-β cell transdifferentiation: how far is it from clinical application?
Glucagon-like peptide-1 promotes α-to-β cell transdifferentiation: how far is it from clinical application? Diabetes Metab. 2019 Jan 17;: Authors: Wei R, Hong T PMID: 30660762 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - January 17, 2019 Category: Endocrinology Authors: Wei R, Hong T Tags: Diabetes Metab Source Type: research

Higher heart rates increase risk of diabetes and cardiovascular events: A prospective cohort study among Inner Mongolians.
Abstract AIM: The study examined the association between resting heart rate and risk of type 2 diabetes (T2D) and cardiovascular events in an Inner Mongolian population. METHODS: Based on a cross-sectional survey carried out in 2003, 2530 participants were reinvestigated between 2013 and 2014. All participants were classified into four groups (quartiles) according to heart rate. Primary outcomes were hypertension, T2D, major macrovascular events and all-cause deaths. Logistic regression models were used to estimate odds ratios (ORs), and shape-restricted cubic spline regressions were conducted to investigate ...
Source: Diabetes and Metabolism - January 11, 2019 Category: Endocrinology Authors: Wang T, Zhang W, Zhang M, Zhang Y, Zhang S Tags: Diabetes Metab Source Type: research

Clinical characteristics of diabetic ketoacidosis in users and non-users of SGLT2 inhibitors.
CONCLUSION: - In this report of recent data on the clinical features of DKA in Korea, patients using SGLT2 inhibitors needed longer treatment in ICUs compared with non-users and had lower levels of blood glucose, whereas DKA associated with SGLT2 inhibitors was rare. PMID: 30639566 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - January 9, 2019 Category: Endocrinology Authors: Jeon JY, Kim SK, Kim KS, Song SO, Yun JS, Kim BY, Kim CH, O Park S, Hong S, Seo H, A Seo J, Noh JH, Kim DJ, DKA Study Group of Gyeonin Branch of the Korean Diabetes Association Tags: Diabetes Metab Source Type: research

Comparative efficacy, safety, and cardiovascular outcomes with once-weekly subcutaneous semaglutide in the treatment of type 2 diabetes: Insights from the SUSTAIN 1-7 trials.
vay I Abstract In individuals with type 2 diabetes, glycaemic control and cardiovascular risk factor management reduces the likelihood of late-stage diabetic complications. Guidelines recommend treatment goals targeting HbA1c, body weight, blood pressure, and low-density lipoprotein cholesterol. Development of new treatments for type 2 diabetes requires an understanding of their mechanism and efficacy, as well as their relative effects compared to other treatment choices, plus demonstration of cardiovascular safety. Subcutaneous semaglutide is a glucagon-like peptide-1 receptor agonist currently approved in severa...
Source: Diabetes and Metabolism - January 4, 2019 Category: Endocrinology Authors: R Aroda V, Ahmann A, Cariou B, Chow F, Davies MJ, Jódar E, Mehta R, Woo V, Lingvay I Tags: Diabetes Metab Source Type: research

Patients with type 1 diabetes in a tertiary setting do not attain recommended lipid targets.
PMID: 30609387 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - January 1, 2019 Category: Endocrinology Authors: Lan NS, Bu BY, Bell DA, Watts GF, Gerry Fegan P Tags: Diabetes Metab Source Type: research

Early screening for gestational diabetes mellitus is not associated with improved pregnancy outcomes: an observational study including 9795 women.
This study evaluated, at our hospital (2012-2016), whether the incidence of a predefined composite outcome (preeclampsia, large-for-gestational-age infant, shoulder dystocia) and secondary outcomes was different when women were screened only after 22WG ('late screening only') or before 22WG and treated for eGDM or OD if present, with repeat screening after 22WG if absent ('early ± late screening'). RESULTS: Early ± late screening (n = 4605, 47.0%) increased between 2012 and 2016 (P 
Source: Diabetes and Metabolism - November 28, 2018 Category: Endocrinology Authors: Cosson E, Vicaut E, Sandre-Banon D, Gary F, Pharisien I, Portal JJ, Banu I, Bianchi L, Cussac-Pillegand C, Dina R, Chiheb S, Valensi P, Carbillon L Tags: Diabetes Metab Source Type: research

Clinical relevance of pharmacokinetic and pharmacodynamic profiles of insulin degludec (100, 200 U/mL) and insulin glargine (100, 300 U/mL) a review of evidence and clinical interpretation.
Abstract AIM: Second-generation basal insulin analogues (e.g. insulin degludec, insulin glargine 300 U/mL), were designed to further extend the duration of insulin action and reduce within-day and day-to-day variability, and consequently hypoglycaemia risk, versus earlier long-acting basal insulins. This review examines the pharmacokinetic/pharmacodynamic characteristics of insulin degludec (100, 200 U/mL) and insulin glargine (100, 300 U/mL), and their influence on clinical outcomes. METHODS: Available pharmacokinetic/pharmacodynamic publications comparing insulin degludec and insulin glargine were reviewed....
Source: Diabetes and Metabolism - November 26, 2018 Category: Endocrinology Authors: R Owens D, S Bailey T, Fanelli C, Yale JF, Bolli GB Tags: Diabetes Metab Source Type: research

Type A competitiveness traits correlate with downregulation of c-Fos expression in patients with type 1 diabetes.
CONCLUSION: This strong association between Type A competitiveness and reduced c-Fos expression is in line with recent data suggesting a psychobiological influence of the Type A profile in T1D via inflammatory pathways. PMID: 30476653 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - November 23, 2018 Category: Endocrinology Authors: Chauvet-Gélinier JC, Mosca-Boidron AL, Lemogne C, Ragot S, Forestier N, Callegarin D, Allard C, Rebaï A, Bouillet B, Ponavoy E, Simoneau I, Petit JM, Bondolfi G, Callier P, Trojak B, Bonin B, Vergès B Tags: Diabetes Metab Source Type: research

Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes.
Abstract AIM: - Natriuretic peptides (NPs) have emerged as important regulators of lipid metabolism. Reduced levels of NPs are reported in obesity and in patients with type 2 diabetes (T2D). This NP deficiency may affect their ectopic fat distribution and lead to high risk of non-alcoholic fatty liver disease (NAFLD). METHODS: - In this cross-sectional study, the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and liver fat content was quantified using 1H-magnetic resonance spectroscopy in 120 patients with T2D. RESULTS: - Mean BMI was 30.3 kg/m2, with a mean HbA1c of 7.5...
Source: Diabetes and Metabolism - November 22, 2018 Category: Endocrinology Authors: Johansen ML, Schou M, Rasmussen J, Rossignol P, Holm MR, Chabanova E, Dela F, Faber J, Kistorp C Tags: Diabetes Metab Source Type: research

Temporality in chronic diseases and adherence to long-term therapies: From philosophy to science and back.
This article gives the rationale for this hypothesis, which is largely grounded on philosophical arguments. Then, it demonstrates the plausibility of the hypothesis: on the one hand, it is consistent with certain epidemiological data found in the literature. On the other, it is possible to predict the underlying mechanisms of this lack of prioritization from recent achievements of neuro-economics and neuroscience. Next, it reviews empirical data that provide an experimental verification for this explanatory hypothesis. Finally, a general evolutionary and philosophical meaning for adherence is proposed, considering the adva...
Source: Diabetes and Metabolism - November 22, 2018 Category: Endocrinology Authors: Reach G Tags: Diabetes Metab Source Type: research

Associations between sleep duration and sleep debt with insulin sensitivity and insulin secretion in the EGIR-RISC Study.
CONCLUSIONS: -Short and long sleep duration are associated with a lower insulin sensitivity, suggesting that sleep plays an important role in insulin resistance and may provide the link with development of type 2 diabetes. PMID: 30439506 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - November 12, 2018 Category: Endocrinology Authors: van Dijk D, Balkau B, Segrestin B, Gottsäter M, Gabriel R, Hatunic M, Mari A, Dekker JM, Rutters F, EGIR-RISC Study group Tags: Diabetes Metab Source Type: research

Impact of different timing of consuming sweet snack on postprandial glucose excursions in healthy women.
Abstract AIMS: - Our aim was to evaluate the acute effect of eating sweet snacks at different times of day on glycaemic parameters in young women without diabetes. METHODS: - In this randomized controlled three-treatment crossover study, 17 women [(means ± SD) age: 21.2 ± 0.8 years, BMI: 20.7 ± 2.5 kg/m2, HbA1c: 36 ± 2 mmol/mol (5.1 ± 0.2%)] wore flash (continuous) glucose monitoring systems for 7 days. Each participant consumed identical test meals on days 4, 5 and 6, but consumed sweet snac...
Source: Diabetes and Metabolism - November 1, 2018 Category: Endocrinology Authors: Nitta A, Imai S, Kajiyama S, Miyawaki T, Matsumoto S, Ozasa N, Kajiyama S, Hashimoto Y, Tanaka M, Fukui M Tags: Diabetes Metab Source Type: research

Glycaemic control and hypoglycaemia risk with insulin glargine 300 U/mL versus glargine 100 U/mL: a patient-level meta-analysis examining older and younger adults with type 2 diabetes.
Abstract AIM: - Older people with type 2 diabetes (T2DM) are at an increased risk of hypoglycaemia and its consequences. However, efficacy and safety data for basal insulin therapy are limited in these individuals. This patient-level meta-analysis assessed the treatment effects of insulin glargine 300 U/mL (Gla-300) versus glargine 100 U/mL (Gla-100) in people with T2DM ≥ 65 years old. METHODS: - Data were pooled for patients randomised to receive Gla-300 or Gla-100 in the Phase 3a, treat-to-target EDITION 1, 2 and 3 trials. Glycaemic efficacy, hypoglycaemia, changes in body weight and insuli...
Source: Diabetes and Metabolism - October 23, 2018 Category: Endocrinology Authors: Yale JF, Aroda VR, Charbonnel B, Sinclair AJ, Trescoli C, Cahn A, Bigot G, Merino-Trigo A, Brulle-Wohlhueter C, Bolli GB, Ritzel R Tags: Diabetes Metab Source Type: research

Association Between Non-Alcoholic Fatty Liver Disease and Bone Turnover Biomarkers in Post-Menopausal Women with Type 2 Diabetes.
CONCLUSION: - In post-menopausal women with T2DM, the presence of NAFLD and significant fibrosis was associated with a low bone turnover, which may reflect the presence of qualitative bone abnormalities. PMID: 30315891 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - October 10, 2018 Category: Endocrinology Authors: Mantovani A, Sani E, Fassio A, Colecchia A, Viapiana O, Gatti D, Idolazzi L, Rossini M, Salvagno G, Lippi G, Zoppini G, Byrne CD, Bonora E, Targher G Tags: Diabetes Metab Source Type: research

Cardiometabolic assessment of lamin A/C gene mutation carriers: A phenotype-genotype correlation.
This study included 29 patients with R482 LMNA mutations, 29 carriers of non-R482 LMNA mutation and 19 control subjects. Cardiac and metabolic phenotypes were compared between groups. A family history of either cardiac implantable electronic devices (CIEDs; P 
Source: Diabetes and Metabolism - October 1, 2018 Category: Endocrinology Authors: Kwapich M, Lacroix D, Espiard S, Ninni S, Brigadeau F, Kouakam C, Degroote P, Laurent JM, Tiffreau V, Jannin A, Humbert L, Ben Hamou A, Tard C, Ben Yaou R, Lamblin N, Klug D, Richard P, Vigouroux C, Bonne G, Vantyghem MC, Diamenord–AEDNL Working Group Tags: Diabetes Metab Source Type: research

Serum levels of osteopontin predict diabetes remission after bariatric surgery.
CONCLUSION: - Although larger studies are still needed to confirm our preliminary results, preoperative OPN serum levels might be useful for predicting 3-year T2DM remission independently of weight loss in patients undergoing bariatric surgery. PMID: 30268840 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 27, 2018 Category: Endocrinology Authors: Carbone F, Adami G, Liberale L, Bonaventura A, Bertolotto M, Andraghetti G, Scopinaro N, Camerini GB, Papadia FS, Cordera R, Dallegri F, Montecucco F Tags: Diabetes Metab Source Type: research

A dietary intervention with functional foods reduces metabolic endotoxaemia and attenuates biochemical abnormalities by modifying faecal microbiota in people with type 2 diabetes.
Tovar A, Torres N Abstract AIM: To study the effects of a functional food-based dietary intervention on faecal microbiota and biochemical parameters in patients with type 2 diabetes (T2D). MATERIALS AND METHODS: This placebo-controlled, randomized, double-blind study included 81 patients with T2D divided into two 3-month treatment groups: one following a reduced-energy diet with a dietary portfolio (DP) comprising high-fibre, polyphenol-rich and vegetable-protein functional foods; the other taking a placebo (P). The primary outcome was the effect of the DP on faecal microbiota. Secondary endpoints were bioche...
Source: Diabetes and Metabolism - September 25, 2018 Category: Endocrinology Authors: Vera IM, Tapia MS, Noriega-López L, Granados-Portillo O, Guevara-Cruz M, Flores-López A, Avila-Nava A, Fernández ML, R Tovar A, Torres N Tags: Diabetes Metab Source Type: research

Clinical and metabolic characterization of obese subjects without non-alcoholic fatty liver: a targeted metabolomics approach.
r E Abstract INTRODUCTION: -: As a small proportion of obese individuals do not develop metabolic complications and non-alcoholic fatty liver disease (NAFLD), this study aimed to provide a comprehensive clinical, metabolic and genetic description of obese subjects with healthy livers. METHODS: -: A total of 183 subjects were stratified, according to BMI, presence of metabolic syndrome, biochemical liver tests and hepatic steatosis on ultrasound, into: (i) lean controls (n = 69); (ii) obese healthy (n = 50); and (iii) obese NAFLD (n = 62) groups. Detailed clinical, gen...
Source: Diabetes and Metabolism - September 25, 2018 Category: Endocrinology Authors: Feldman A, Eder SK, Felder TK, Paulweber B, Zandanell S, Stechemesser L, Schranz M, Strebinger G, Huber-Schönauer U, Niederseer D, Patsch W, Weghuber D, Tevini J, Datz C, Aigner E Tags: Diabetes Metab Source Type: research

Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: the potential contribution to diabetes complications and cardiovascular disease.
Abstract Chronic low-grade inflammation is a recognized key feature associated with type 2 diabetes mellitus (T2DM) and its complications. In prospective randomized trials, sodium-glucose cotransporter type 2 (SGLT2) inhibitors have demonstrated benefits related to several cardiovascular and renal risk factors, including HbA1c, blood pressure, body weight, renal hyperfiltration and improvement of cardiorenal outcomes. SGLT2 inhibitors may improve adipose tissue function and induce decreases in serum leptin, TNF-α and IL-6 while increasing adiponectin. While data on high-sensitivity C-reactive protein and oth...
Source: Diabetes and Metabolism - September 25, 2018 Category: Endocrinology Authors: Bonnet F, Scheen AJ Tags: Diabetes Metab Source Type: research

Comparing once-weekly semaglutide to incretin-based therapies in patients with type 2 diabetes: a systematic review and meta-analysis.
CONCLUSIONS: While both once-weekly semaglutide and other incretin-based therapies can reduce haemoglobin A1c, semaglutide causes a more potent haemoglobin A1c reduction and greater weight loss when compared to other incretin-based therapies. However, this potent effect of semaglutide was associated with a higher incidence of gastrointestinal side effects. Additional studies are needed to determine whether this marked reduction in both haemoglobin A1c and body weight may translate into improved cardiovascular outcomes. PMID: 30243806 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 20, 2018 Category: Endocrinology Authors: Basem MM, Doyle MC, James RP, Kerry AS, Robert JT Tags: Diabetes Metab Source Type: research

High-intensity interval training is more effective than moderate-intensity continuous training in reducing abdominal fat mass in postmenopausal women with type 2 diabetes: a randomized crossover study.
PMID: 30243615 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 19, 2018 Category: Endocrinology Authors: Maillard F, Rousset S, Bruno P, Boirie Y, Duclos M, Boisseau N Tags: Diabetes Metab Source Type: research

Digital diabetes: perspectives for diabetes prevention, management and research.
Abstract Digital medicine, digital research and artificial intelligence (AI) have the power to transform the field of diabetes with continuous and no-burden remote monitoring of patients' symptoms, physiological data, behaviours, and social and environmental contexts through the use of wearables, sensors and smartphone technologies. Moreover, data generated online and by digital technologies-which the authors suggest be grouped under the term 'digitosome'-constitute, through the quantity and variety of information they represent, a powerful potential for identifying new digital markers and patterns of risk that, u...
Source: Diabetes and Metabolism - September 19, 2018 Category: Endocrinology Authors: Fagherazzi G, Ravaud P Tags: Diabetes Metab Source Type: research

Complement deposition on renal histopathology of patients with diabetic nephropathy.
Abstract AIMS: - As the potential role of the complement system in diabetic nephropathy (DN) is increasingly reported, this study aimed to investigate C1q and C3c deposition as seen on renal histopathology, as well as its association with clinical and pathological parameters, in DN patients. METHODS: - Renal biopsy specimens from 161 DN patients were investigated using direct immunofluorescence and light and electron microscopy. For direct immunofluorescence, staining for C1q and C3c on fresh-frozen renal tissue was performed immediately after biopsy. Complement deposition was defined as the presence of C1q o...
Source: Diabetes and Metabolism - September 19, 2018 Category: Endocrinology Authors: Sun ZJ, Li XQ, Chang DY, Wang SX, Liu G, Chen M, Zhao MH Tags: Diabetes Metab Source Type: research

Effect of liraglutide on physical performance in type 2 diabetes: Results of a randomized, double-blind, controlled trial (LIPER2).
CONCLUSION: - In this trial, liraglutide improved glycaemic control in T2D, but had no significant effects on either physical performance or myocardial function. PMID: 30223083 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 14, 2018 Category: Endocrinology Authors: Wägner AM, Miranda-Calderín G, Ugarte-Lopetegui MA, Marrero-Santiago H, Suárez-Castellano L, López-Madrazo MJ, Alberiche-Ruano MDP, Ahmed NA, Alemán C, Castellot-Martín A, Pino ADD, Nóvoa-Mogollón FJ Tags: Diabetes Metab Source Type: research

Indications for islet or pancreatic transplantation: Statement of the TREPID Working Group on behalf of the Soci été Francophone du Diabète (SFD), Société Francaise d'Endocrinologie (SFE), Société Francophone de Transplantation (SFT) and Société Française de Néphrologie-Dialyse-Transplantation (SFNDT).
Indications for islet or pancreatic transplantation: Statement of the TREPID Working Group on behalf of the Société Francophone du Diabète (SFD), Société Francaise d'Endocrinologie (SFE), Société Francophone de Transplantation (SFT) and Société Française de Néphrologie-Dialyse-Transplantation (SFNDT). Diabetes Metab. 2018 Sep 14;: Authors: Wojtusciszyn A, Branchereau J, Esposito L, Badet L, Buron F, Chetboun M, Kessler L, Morelon E, Berney T, Pattou F, Benhamou PY, Vantyghem MC Abstract While either pancreas or pancreatic isl...
Source: Diabetes and Metabolism - September 14, 2018 Category: Endocrinology Authors: Wojtusciszyn A, Branchereau J, Esposito L, Badet L, Buron F, Chetboun M, Kessler L, Morelon E, Berney T, Pattou F, Benhamou PY, Vantyghem MC Tags: Diabetes Metab Source Type: research

Association of treatment-achieved HbA1c with incidence of coronary artery disease and severe eye disease in diabetes patients.
CONCLUSION: These findings suggest that the relationship between treatment-achieved HbA1c and incidence of both CAD and severe diabetic eye disease differed according to treatment, based on a large-scale real-life database. More research is now needed to confirm these findings and to further investigate the underlying mechanisms. PMID: 30213710 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 10, 2018 Category: Endocrinology Authors: Harada M, Fujihara K, Osawa T, Yamamoto M, Kaneko M, Ishizawa M, Matsubayashi Y, Yamada T, Yamanaka N, Seida H, Kodama S, Ogawa W, Sone H Tags: Diabetes Metab Source Type: research

Burden of diabetes, hyperglycaemia in China from to 2016: findings from the 1990 2016, Global Burden of Disease study.
CONCLUSION: . - Diabetes and hyperglycaemia constitute a huge health burden in China. The substantial increase in diabetes-related burden represents an ongoing challenge, given the rapidly ageing Chinese population. Thus, a targeted control and preventative strategy needs to be developed at risk-factor level to reduce this burden. PMID: 30196138 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 6, 2018 Category: Endocrinology Authors: Liu M, Liu S, Wang L, Bai Y, Zeng X, Guo H, Liu Y, Jiang Y, Dong W, He G, Zhou M, Shicheng Y Tags: Diabetes Metab Source Type: research

Association between Decreasing Estimated Glomerular Filtration Rate and Risk of Cardiac Conduction Defects in Patients with Type 2 Diabetes.
We examined a hospital-based sample of 923 patients with T2DM discharged from our Division of Endocrinology over the years 2007-2014. Standard electrocardiograms (ECGs) were performed in all patients. eGFR was estimated by using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, whilst albuminuria was measured by an immuno-nephelometric method on morning spot urine samples. RESULTS: A total of 253 (27.4%) patients had some type of cardiac conduction defects on ECGs (defined as at least one heart block among first-degree atrio-ventricular block, second-degree block, third-degree block, left bundl...
Source: Diabetes and Metabolism - September 5, 2018 Category: Endocrinology Authors: Mantovani A, Rigolon R, Turino T, Pichiri I, Falceri A, Rossi A, Temporelli PL, Bonapace S, Lippi G, Zoppini G, Bonora E, Byrne CD, Targher G Tags: Diabetes Metab Source Type: research

Type 1 innate lymphoid cells are associated with type 2 diabetes.
Abstract AIM: -: Type 1 innate lymphoid cells (ILC1s) play a major role in regulating systemic inflammatory diseases. However, the relationship between ILC1s and type 2 diabetes (T2D) remains unclear. Thus, the present study investigated the relationship between ILC1s and glucose homoeostasis in humans. METHODS: -- A total of 37 newly diagnosed T2D patients and 32 subjects with normal glucose tolerance (NGT), matched for age and body mass index (BMI), were enrolled in the study. Flow cytometric analysis of ILC1s derived from peripheral blood mononuclear cells (PBMCs) and omental adipose tissue was performed. ...
Source: Diabetes and Metabolism - September 3, 2018 Category: Endocrinology Authors: Liu F, Wang H, Feng W, Ye X, Sun X, Jiang C, Chu X, Zhang P, Jiang C, Wang Y, Zhu D, Bi Y Tags: Diabetes Metab Source Type: research

Obstructive sleep apnoea syndrome in patients living with diabetes: which patients should be screened?
CONCLUSION: The high prevalence of OSAS in patients with T1D and T2D justifies screening for the syndrome, which should be based on clinical symptoms, as the benefits of OSAS treatment are mainly improvement of symptoms related to sleep apnoea. There are also several clinical situations wherein screening for OSAS seems justified in diabetes patients even when they have no symptoms, particularly to optimalize control of blood pressure in cases of resistant hypertension and microvascular complications. PMID: 30189344 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 3, 2018 Category: Endocrinology Authors: Borel AL, Tamisier R, Böhme P, Priou P, Avignon A, Benhamou PY, Hanaire H, Pépin JL, Kessler L, Valensi P, Darmon P, Gagnadoux F Tags: Diabetes Metab Source Type: research

Irisin levels in lmna-associated partial lipodystrophies.
CONCLUSION: -: Circulating irisin is similarly increased in FPLD2 and OND patients, who are characterized by higher lean body mass regardless of their clearly different fat mass. However, irisin/leptin ratios, strikingly higher in FPLD2 than in OND patients, could help to make the diagnosis and prompt genetic testing in clinically atypical cases. PMID: 30165155 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - August 27, 2018 Category: Endocrinology Authors: Bensmaïne F, Benomar K, Espiard S, Vahe C, LE Mapihan K, Lion G, Lemdani M, Chazard E, Ernst O, Vigouroux C, Pigny P, Marie-Christine V Tags: Diabetes Metab Source Type: research

Timing of insulin basal rate reduction to reduce hypoglycemia during late postprandial exercise in adults with type 1 diabetes using insulin pump therapy: a randomized crossover trial.
ret R Abstract AIMS: To compare the efficacy of three timings to decrease basal insulin infusion rate to reduce exercise-induced hypoglycaemia in patients with type 1 diabetes (T1D) using pump therapy. METHODS: A single-blinded, randomized, 3-way crossover study in 22 adults that had T1D>1 year and using insulin pump>3 months (age, 40 ± 15 years; HbA1c, 56.3 ± 10.2 mmol/mol). Participants practiced three 45-min exercise sessions (ergocyle) at 60% VO2peak 3 hours after lunch comparing an 80% reduction of basal insulin applied 40 minute...
Source: Diabetes and Metabolism - August 27, 2018 Category: Endocrinology Authors: Roy-Fleming A, Taleb N, Messier V, Suppère C, Cameli C, Elbekri S, Smaoui MR, Ladouceur M, Legault L, Rabasa-Lhoret R Tags: Diabetes Metab Source Type: research

MicroRNAs from urinary extracellular vesicles are non-invasive early biomarkers of diabetic nephropathy in type 2 diabetes patients with the 'Asian Indian phenotype'.
CONCLUSION: -: Urinary EV miRNAs correlate with the degree of MIC. As they are also thought to regulate pathways that are targets of pharmacological agents to prevent DN (reticulum stress, activin receptors), they may also serve as non-invasive 'liquid biopsies' to stratify patients at risk of developing MAC and to monitor treatment efficacy. PMID: 30165157 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - August 27, 2018 Category: Endocrinology Authors: Prabu P, Rome S, Sathishkumar C, Gastebois C, Meugnier E, Mohan V, Balasubramanyam M Tags: Diabetes Metab Source Type: research

SGLT2 inhibitors and incretin agents: associations with alanine aminotransferase activity in type 2 diabetes.
Abstract AIM: -: The impact of new classes of glucose lowering medications on markers of nonalcoholic fatty liver disease (NAFLD) associated with type 2 diabetes (T2D) have been inconsistent in their magnitude and independence. This large retrospective study investigates changes in alanine aminotransferase (ALT) levels among subjects initiated on newer classes of T2D medications in comparison to a reference control group. METHODS: - We studied people with T2D from a large Canadian diabetes register, who had canagliflozin, dapagliflozin, liraglutide, sitagliptin or no further treatment added to their diabetes ...
Source: Diabetes and Metabolism - August 24, 2018 Category: Endocrinology Authors: Bajaj HS, Brown RE, Bhullar L, Sohi N, Kalra S, Aronson R Tags: Diabetes Metab Source Type: research