Is there an association between metformin use and clinical outcomes in diabetes patients with COVID-19?
CONCLUSION: No definite association could be found between metformin use and clinical outcomes, including survival. However, given the disproportionate participant numbers in our groups and small number of events, further studies are needed to determine whether the use of metformin has favourable or unfavourable effects in DM patients with COVID-19. PMID: 33160030 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - November 4, 2020 Category: Endocrinology Authors: Do JY, Kim SW, Park JW, Cho KH, Kang SH Tags: Diabetes Metab Source Type: research

Fasting serum copeptin and asymptomatic peripheral artery disease: No association in patients with type 1 diabetes mellitus.
CONCLUSION: As serum copeptin does not appear to be associated with aPAD in patients with T1DM, further studies are now needed to elucidate whether it has any other potential role to play in the subclinical vascular disease of this patient population. PMID: 33160031 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - November 4, 2020 Category: Endocrinology Authors: Nattero-Chávez L, Martínez-García MÁ, Fernández-Durán E, Redondo López S, Dorado Avendaño B, Escobar-Morreale HF, Luque-Ramírez M Tags: Diabetes Metab Source Type: research

Practical implementation of automated closed-loop insulin delivery: a French position statement.
N, Lablanche S, Leroy R, Melki V, Munch M, Penfornis A, Picard S, Place J, Riveline JP, Serusclat P, Sola-Gazagnes A, Thivolet C, Hanaire H, Benhamou PY, SFD, SFD Paramedical, SFE, SFEDP, AJD, FFD, FENAREDIAM and CNP-EDN Abstract Automated closed-loop (CL) insulin therapy has come of age. This major technological advance is expected to significantly improve the quality of care for adults, adolescents and children with type 1 diabetes. To improve access to this innovation for both patients and healthcare professionals (HCPs), and to promote adherence to its requirements in terms of safety, regulations, ethics and p...
Source: Diabetes and Metabolism - November 2, 2020 Category: Endocrinology Authors: Tubiana-Rufi N, Schaepelynck P, Franc S, Chaillous L, Joubert M, Renard E, Reznik Y, Abettan C, Bismuth E, Beltrand J, Bonnemaison E, Borot S, Charpentier G, Delemer B, Desserprix A, Durain D, Farret A, Filhol N, Guerci B, Guilhem I, Guillot C, Jeandidier Tags: Diabetes Metab Source Type: research

Diabetes mellitus in the era of climate change.
Abstract Worldwide, diabetes mellitus (DM) represents a major public-health problem due to its increasing prevalence in tandem with the rising trend of obesity. However, climate change, with its associated negative health effects, also constitutes a worrisome problem. Patients with DM are experiencing more visits to emergency departments, hospitalizations, morbidity and mortality during heat waves at ever-increasing numbers. Such patients are particularly vulnerable to heat waves due to impaired thermoregulatory mechanisms in conjunction with impaired autonomous nervous system responses at high temperatures, elect...
Source: Diabetes and Metabolism - October 27, 2020 Category: Endocrinology Authors: Vallianou NG, Geladari EV, Kounatidis D, Geladari CV, Stratigou T, Dourakis SP, Andreadis EA, Dalamaga M Tags: Diabetes Metab Source Type: research

Routine use of statins and increased mortality related to COVID-19 in inpatients with type 2 diabetes: Results from the CORONADO study.
Abstract AIM: Patients with type 2 diabetes mellitus (T2DM) represent a high-risk population for both cardiovascular diseases and severe coronavirus disease 2019 (COVID-19). Recent studies have reported interactions between statin treatment and COVID-19-related outcomes. The study reported here specifically assessed the association between routine statin use and COVID-19-related outcomes in inpatients with T2DM. METHODS: The Coronavirus-SARS-CoV-2 and Diabetes Outcomes (CORONADO) study was a nationwide observational study aiming to describe the phenotypic characteristics and prognosis of T2DM patients with CO...
Source: Diabetes and Metabolism - October 19, 2020 Category: Endocrinology Authors: Cariou B, Goronflot T, Rimbert A, Boullu S, Le May C, Moulin P, Pichelin M, Potier L, Smati S, Sultan A, Tramunt B, Wargny M, Gourdy P, Hadjadj S, CORONADO investigators Tags: Diabetes Metab Source Type: research

Lean non-alcoholic fatty liver disease and risk of incident diabetes in a euglycaemic population undergoing health check-ups: A cohort study.
CONCLUSION: Lean NAFLD is indeed a risk factor for incident type 2 diabetes in both genders, although the effect appeared to be more pronounced in women than in men. Further investigations are now needed to obtain a better understanding of the natural history of NAFLD in lean subjects. PMID: 33075504 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - October 16, 2020 Category: Endocrinology Authors: Wei L, Cheng X, Luo Y, Yang R, Lei Z, Jiang H, Chen L Tags: Diabetes Metab Source Type: research

Effects of COVID-19 pandemic lockdown on gestational diabetes mellitus: A retrospective study.
ambergue A PMID: 33069845 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - October 15, 2020 Category: Endocrinology Authors: Ghesquière L, Garabedian C, Drumez E, Lemaître M, Cazaubiel M, Bengler C, Vambergue A Tags: Diabetes Metab Source Type: research

Associations between serum total, free and bioavailable testosterone and non-alcoholic fatty liver disease in community-dwelling middle-aged and elderly women.
Abstract BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) is considered both a cause and consequence of the metabolic syndrome (MetS). While emerging evidence has indicated that testosterone is associated with MetS, the relationship between testosterone and NAFLD in women remains unclear. Therefore, this study investigated the associations between serum testosterone levels and NAFLD prevalence risk in a community-based cross-sectional study. METHODS: A total of 2117 adult women were included in the analysis. Serum total testosterone (TT) was measured by chemiluminescence immunoassay, and other t...
Source: Diabetes and Metabolism - October 12, 2020 Category: Endocrinology Authors: Wang X, Li Q, Pang J, Lin J, Liu Y, Xu Z, Zhang H, Shen T, Chen X, Ma J, Xu X, Ling W, Chen Y Tags: Diabetes Metab Source Type: research

Indispensable but deceptive evidence-based medicine.
This article discusses how and why evidence-based medicine can be deceitful, and provides examples to illustrate this point of view. PMID: 33049401 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - October 10, 2020 Category: Endocrinology Authors: Funck-Brentano C Tags: Diabetes Metab Source Type: research

Fasting plasma glucose variability in midlife and risk of Parkinson's disease: A nationwide population-based study.
Abstract AIM: Despite the recognized association between type 2 diabetes (T2D) and Parkinson's disease (PD), the implications of glycaemic variability for patients with PD are as yet unknown. For this reason, our study assessed the future risk of incident PD according to visit-to-visit fasting plasma glucose (FPG) variability, as calculated by standard deviation (FPG-SD), coefficient variance (FPG-CV) and variability independent of the mean (FPG-VIM). METHODS: Using the Korean National Health Insurance Service Health Screening Cohort, 131,625 Korean adults without diabetes were followed. They were divided int...
Source: Diabetes and Metabolism - October 8, 2020 Category: Endocrinology Authors: Chung HS, Lee JS, Kim JA, Roh E, Lee YB, Hong SH, Yu JH, Kim NH, Yoo HJ, Seo JA, Kim SG, Kim NH, Baik SH, Choi KM Tags: Diabetes Metab Source Type: research

Statistical and clinical significances: Are they equivalent?
PMID: 33039670 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - October 8, 2020 Category: Endocrinology Authors: Monnier L, Bonnet F Tags: Diabetes Metab Source Type: research

Prognosis associated with initial care of increased fasting glucose in early pregnancy: A retrospective study.
Abstract AIM: To evaluate whether the initial care of women with fasting plasma glucose (FPG) levels at 5.1-6.9mmol/L before 22 weeks of gestation (WG), termed 'early fasting hyperglycaemia', is associated with fewer adverse outcomes than no initial care. METHODS: A total of 523 women with early fasting hyperglycaemia were retrospectively selected in our department (2012-2016) and separated into two groups: (i) those who received immediate care (n=255); and (ii) those who did not (n=268), but had an oral glucose tolerance test (OGTT) at or after 22 WG, with subsequent standard care if hyperglycaemia (by WHO c...
Source: Diabetes and Metabolism - October 8, 2020 Category: Endocrinology Authors: Cosson E, Vicaut E, Berkane N, Cianganu TL, Baudry C, Portal JJ, Boujenah J, Valensi P, Carbillon L Tags: Diabetes Metab Source Type: research

SGLT2i as fourth-line therapy and risk of mortality, end-stage renal diseases and cardiovascular diseases in patients with type 2 diabetes mellitus.
CONCLUSION: Among T2DM patients initiating fourth-line therapy, SGLT2i users had significant benefits in lowering risk of CVD, and potential benefits in lowering risks of ESRD and all-cause mortality. SGLT2i was the preferred fourth-line glucose-lowering medication least likely to be associated with complication risks. PMID: 33039672 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - October 8, 2020 Category: Endocrinology Authors: Wong CKH, Tang EHM, Man KKC, Chan EWY, Wong ICK, Lam CLK Tags: Diabetes Metab Source Type: research

Immune Checkpoint Inhibitors and Diabetes: Mechanisms and Predictors.
Abstract The emergence of immune checkpoint inhibitors in the arsenal of cancer immunotherapy was a breakthrough which provided hope to many cancer patients. However, not long has passed since their discovery that some adverse effects were associated with these promising therapeutic agents. Immune checkpoint inhibitors dysregulate host immunity and may precipitate autoimmune diseases including diabetes mellitus. In this review, we go beyond the case reports towards understanding the underlying mechanisms by which Programmed cell death 1 (PD-1) and Programmed death ligand-1 (PD-L1) inhibitors precipitate diabetes. ...
Source: Diabetes and Metabolism - September 29, 2020 Category: Endocrinology Authors: Youssef N, Noureldein M, Daoud G, Eid AA Tags: Diabetes Metab Source Type: research

The obesity treatment dilemma: Why dieting is both the answer and the problem? A mechanistic overview.
Abstract Restricted-calorie diets are the most worldwide used treatments for obesity. Although such strategies are based on the first law of thermodynamics, the real life clinical practice demonstrates that the observed weight losses are divergent from those theoretically predicted. Loosely adherence to recommendations is one of the main causes for the limited efficacy of dieting, but many additional factors can be involved in the hurdles to weight loss. According to the second law of thermodynamics any restriction in dietary energy intake results in energy sparing with a diminution in the basal metabolic rate and...
Source: Diabetes and Metabolism - September 27, 2020 Category: Endocrinology Authors: Monnier L, Schlienger JL, Colette C, Bonnet F Tags: Diabetes Metab Source Type: research

Cardiovascular disease with type 1 diabetes: A review of epidemiological data and underlying mechanisms.
e;s B Abstract Cardiovascular disease (CVD) is highly prevalent in patients with type 1 diabetes (T1D) and a major cause of mortality. CVD arises earlier in life in T1D patients and is responsible for a significant reduction of at least 11 years' life expectancy. Also, the incidence of CVD is much more pronounced in patients with T1D onset at an earlier age. However, the factors responsible for increased atherosclerosis and CVD in T1D are not yet totally clarified. In addition to the usual cardiovascular (CV) risk factors, chronic hyperglycaemia plays an important role by promoting oxidative stress, vascula...
Source: Diabetes and Metabolism - September 26, 2020 Category: Endocrinology Authors: Vergès B Tags: Diabetes Metab Source Type: research

Effect of high-dose mineralocorticoid receptor antagonist eplerenone on urinary albumin excretion in patients with type 2 diabetes and high cardiovascular risk: Data from the MIRAD trial.
Abstract AIM: As mineralocorticoid receptor antagonists (MRAs) may possess renoprotective effects in type 2 diabetes (T2D), it was decided to investigate the impact of high-dose MRA on prespecified secondary endpoints-namely, change in urinary albumin-creatinine ratio (UACR) and 24-h ambulatory blood pressure-in the MIRAD trial. METHODS: This was a double-blind clinical trial in which T2D patients at high risk of or with established cardiovascular disease (CVD) were randomized to either high-dose (100-200 mg) eplerenone or a dose-matched placebo as an add-on to background antihypertensive treatment for...
Source: Diabetes and Metabolism - September 8, 2020 Category: Endocrinology Authors: Brandt-Jacobsen NH, Johansen ML, Rasmussen J, Forman JL, Holm MR, Faber J, Rossignol P, Schou M, Kistorp C Tags: Diabetes Metab Source Type: research

Elevated fasting blood glucose at admission is associated with poor outcomes in patients with COVID-19.
PMID: 32896652 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 3, 2020 Category: Endocrinology Authors: Liu S, Zhang B, You J, Chen L, Yuan H, Zhang S Tags: Diabetes Metab Source Type: research

Sodium-glucose cotransporter-2 inhibitors for diabetic kidney disease: Targeting Warburg effects in proximal tubular cells.
Abstract Inhibitors of sodium-glucose cotransporter 2 (SGLT2) have undoubtedly shifted the paradigm for diabetes medicine and research and, especially, diabetic kidney disease (DKD). The pharmacological action of SGLT2 inhibitors is simply the release of glucose into urine; however, precisely how SGLT2 inhibitors contribute to the health of those with diabetes has still not been completely elucidated. Towards this end, the present report provides a novel insight into the action of SGLT2 inhibitors by highlighting a neglected fuel-burning system found in proximal tubular cells-'glycolysis'. In addition, exploring t...
Source: Diabetes and Metabolism - September 2, 2020 Category: Endocrinology Authors: Morita M, Kanasaki K Tags: Diabetes Metab Source Type: research

Pregnant type 1 diabetes women with rises in C-peptide display higher levels of regulatory T cells: A pilot study.
PMID: 32891755 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 2, 2020 Category: Endocrinology Authors: Amouyal C, Klatzmann D, Tibi E, Salem JE, Halbron M, Popelier M, Jacqueminet S, Ciangura C, Bourron O, Andreelli F, Hartemann A, Rosenzwajg M Tags: Diabetes Metab Source Type: research

Bidirectional relationship between diabetes and pulmonary function: A systematic review and meta-analysis.
CONCLUSION: There is a bidirectional relationship between diabetes and pulmonary function. However, further investigations into whether dynamic changes in glycaemic levels before and shortly after diabetes onset mediate the deleterious effects on pulmonary function, or vice versa, are now required. PMID: 32889114 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - August 31, 2020 Category: Endocrinology Authors: Zhang RH, Cai YH, Shu LP, Yang J, Qi L, Han M, Zhou J, Simó R, Lecube A Tags: Diabetes Metab Source Type: research

Risk stratification and screening for coronary artery disease in asymptomatic patients with diabetes mellitus.
PMID: 32846201 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - August 22, 2020 Category: Endocrinology Authors: Valensi P, Belle EV, Cosson E, Emmerich J, Prevost G, Ferriere J, Sultan A, Ernande L, Rouzet F, Marcadet D, Mousseau E, Boccara F, Verges B, Henry P Tags: Diabetes Metab Source Type: research

Comparison of efficacy and safety of empagliflozin vs linagliptin added to premixed insulin in patients with uncontrolled type 2 diabetes: a randomized, open-label study.
This study compared the efficacy and safety of empagliflozin and linagliptin added to premixed insulin therapy in patients with poorly controlled T2DM. METHODS: In this 24-week, open-label, parallel-design randomized controlled trial, patients with poorly controlled T2DM despite a premixed insulin regimen were randomized to receive 5mg of linagliptin (n=53) or 25mg of empagliflozin (n=53) for 24 weeks. RESULTS: At week 24, changes in glycated haemoglobin (HbA1c) from baseline were -0.06±0.17% and -1.01±0.16% in the linagliptin and empagliflozin groups, respectively, and the mean treatment HbA1c diff...
Source: Diabetes and Metabolism - August 18, 2020 Category: Endocrinology Authors: Liu SC, Lee CC, Chuang SM, Sun FJ, Zeng YH Tags: Diabetes Metab Source Type: research

Trimethylamine N-Oxide levels are associated with NASH in obese subjects with type 2 diabetes.
CONCLUSIONS: In obese patients, circulating TMAO levels were associated with NASH mainly in the presence of T2D. Functional studies are required to evaluate the role of insulin resistance and T2D in this association, both highly prevalent in NASH patients. PMID: 32791310 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - August 9, 2020 Category: Endocrinology Authors: León-Mimila P, Villamil-Ramírez H, Li XS, Shih DM, Hui ST, Ocampo-Medina E, López-Contreras B, Morán-Ramos S, Olivares-Arevalo M, Grandini-Rosales P, Macías-Kauffer L, González-González I, Hernández-Pando R, Gómez-Pérez F, Campos-Pérez F, Aguil Tags: Diabetes Metab Source Type: research

The discovery of insulin in 1914: Georg Z ülzer, from Berlin, and Camille Reuter, the forgotten chemist from Luxembourg.
The discovery of insulin in 1914: Georg Zülzer, from Berlin, and Camille Reuter, the forgotten chemist from Luxembourg. Diabetes Metab. 2020 Aug 01;: Authors: Jörgens V PMID: 32750450 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - July 31, 2020 Category: Endocrinology Authors: Jörgens V Tags: Diabetes Metab Source Type: research

Metformin and COVID-19: From cellular mechanisms to reduced mortality.
Abstract Type 2 diabetes mellitus (T2DM) is associated with both poorer clinical outcomes during the COVID-19 pandemic and an increased risk of death in such hospitalized patients. While the role of glucose control has been emphasized to improve the prognosis, the impact of different glucose-lowering agents remains largely unknown. Metformin remains the first-line pharmacological choice for the management of hyperglycaemia in T2DM. Because metformin exerts various effects beyond its glucose-lowering action, among which are anti-inflammatory effects, it may be speculated that this biguanide might positively influen...
Source: Diabetes and Metabolism - July 31, 2020 Category: Endocrinology Authors: Scheen AJ Tags: Diabetes Metab Source Type: research

Non-alcoholic fatty liver disease and chronic kidney disease: renal benefit with liver stiffness assessment?
PMID: 32750452 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - July 31, 2020 Category: Endocrinology Authors: Caussy C Tags: Diabetes Metab Source Type: research

Influence of sexual orientation on diabetes management in US adults with diabetes.
We examined the impact of sexual orientation on current US diabetes management levels in a geographically diverse sample of people with diabetes (PWD). METHOD: Adult PWDs were identified from the 2015-2018 cross-sectional Behavioural Risk Factor Surveillance System surveys. We determined the unadjusted percentage and the adjusted odds ratios (OR) of noncompliance with American Diabetes Association (ADA) diabetes management measures (
Source: Diabetes and Metabolism - July 31, 2020 Category: Endocrinology Authors: Tran P, Tran L, Tran L Tags: Diabetes Metab Source Type: research

Body Mass Index and Outcome in Patients with COVID-19: A Dose-Response Meta-Analysis.
Abstract BACKGROUND: There is mounting evidence related to the association between obesity and severity of COVID-19. However, the direct relationship of the increase in the severe COVID-19 risk factors, with an increase in body mass index (BMI), has not yet been evaluated. AIM: This meta-analysis aims to evaluate the dose-response relationship between body mass index (BMI) and poor outcome in patients with COVID-19. METHODS: A systematic literature search was conducted using PubMed, Europe PMC, ProQuest, and the Cochrane Central Database. The primary outcome was composite poor outcome composed of mortali...
Source: Diabetes and Metabolism - July 28, 2020 Category: Endocrinology Authors: Pranata R, Lim MA, Yonas E, Vania R, Lukito AA, Siswanto BB, Meyer M Tags: Diabetes Metab Source Type: research

Euglycaemic ketoacidosis during gestational diabetes with concomitant COVID-19 infection.
PMID: 32738403 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - July 28, 2020 Category: Endocrinology Authors: Smati S, Moreau PM, Bourdiol A, Ploteau S, Hadjadj S, Cariou B Tags: Diabetes Metab Source Type: research

Acute hyperglycaemia can impair driving skill in young type 1 diabetes mellitus patients.
Abstract AIM: Drivers with diabetes are at increased risk of being involved in road accidents. Therefore, this study aimed to evaluate the effects of acute hyperglycaemia (AH) compared with euglycaemia on driving ability in patients with type 1 diabetes mellitus (T1DM). METHODS: Eighteen drivers with T1DM were asked to navigate twice through nine hazardous scenarios, using a driving simulator, during euglycaemia and then again during AH (mean blood glucose: 138 ± 34 mg/dL and 321 ± 29 mg/dL, respectively) in a counterbalanced crossover study. Driving per...
Source: Diabetes and Metabolism - July 27, 2020 Category: Endocrinology Authors: Haim A, Shamay RS, Ridel D, Parmet Y, Loewenthal N, Liberty I, Tejman-Yarden S, Hershkovitz E, Borowsky A Tags: Diabetes Metab Source Type: research

Distinct uric acid trajectories are associated with incident diabetes in an overweight Chinese population.
Abstract AIM: To explore uric acid (UA) trajectories in different body mass index (BMI) populations and to determine their associations with incident diabetes. METHODS: A total of 4566 adults without diabetes in 2011 were enrolled. All participants underwent a medical examination every year until 2016, and were classified into three subgroups based on BMI: non-obese (BMI
Source: Diabetes and Metabolism - July 26, 2020 Category: Endocrinology Authors: Li F, Duan J, Yang Y, Yan G, Chen Z, Wang J, Yuan H, Yao L Tags: Diabetes Metab Source Type: research

Gender and age differences in the association between sleep characteristics and fasting glucose levels in Chinese adults.
CONCLUSION: - Night-time sleep duration, midday napping duration and bedtime were all independently associated with the risk of hyperglycaemia, and some of the associations between these sleep characteristics and hyperglycaemia were gender- and age-dependent. PMID: 32659495 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - July 9, 2020 Category: Endocrinology Authors: Zheng R, Niu J, Wu S, Wang T, Wang S, Xu M, Chen Y, Dai M, Zhang D, Yu X, Tang X, Hu R, Ye Z, Shi L, Su Q, Yan L, Qin G, Wan Q, Chen G, Gao Z, Wang G, Shen F, Luo Z, Qin Y, Chen L, Huo Y, Li Q, Zhang Y, Liu C, Wang Y, Wu S, Yang T, Deng H, Chen L, Zhao J, Tags: Diabetes Metab Source Type: research

SGLT2 inhibition during the COVID-19 epidemic: friend or foe?
PMID: 32562762 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - June 16, 2020 Category: Endocrinology Authors: Scheen AJ Tags: Diabetes Metab Source Type: research

Application of medium-term metrics for assessing glucose homoeostasis: Usefulness, strengths and weaknesses.
Abstract This review aims to address the issue of whether or not the newer metrics developed for continuous glucose monitoring [real-time CGM (rtCGM), intermittently scanned CGM (isCGM)] enhance assessment of the 'glucose tetrad': ambient hyperglycaemia, short-term glycaemic variability, postprandial glucose excursions and hypoglycaemia. The ever-increasing number of metrics offered with rtCGM and isCGM includes intermediate-term indicators referred to as 'time in range' (TIR), the time spent in the range of 70-180 mg/dL (TIR 70-180); time spent above the range of 180 mg/dL (TAR> 180); and time spent below the ...
Source: Diabetes and Metabolism - June 15, 2020 Category: Endocrinology Authors: Monnier L, Colette C, Owens D Tags: Diabetes Metab Source Type: research

Lifestyle changes in patients with morbid obesity and type 2 diabetes mellitus during the COVID-19 pandemic.
PMID: 32561429 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - June 15, 2020 Category: Endocrinology Authors: Wysocki M, Walędziak M, Proczko-Stepaniak M, Pędziwiatr M, Szeliga J, Major P Tags: Diabetes Metab Source Type: research

Massive lactic acidosis and ketoacidosis with glucagon deficiency in a chronic alcoholic patient.
, Boissan M PMID: 32531474 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - June 8, 2020 Category: Endocrinology Authors: Boudou P, Djibré M, Ibrahim F, Fellahi S, Gilon P, Andreelli F, Ferré P, Boissan M Tags: Diabetes Metab Source Type: research

Detrimental effects of metabolic dysfunction-associated fatty liver disease and increased neutrophil-to-lymphocyte ratio on severity of COVID-19.
PMID: 32505652 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - June 3, 2020 Category: Endocrinology Authors: Targher G, Mantovani A, Byrne CD, Wang XB, Yan HD, Sun QF, Pan KH, Zheng KI, Chen YP, Eslam M, George J, Zheng MH Tags: Diabetes Metab Source Type: research

Pumps that predict and manage low blood glucose are superior to pumps with stand-alone CGM for reducing hypoglycaemia in type 1 diabetes patients in a real-world setting.
This study aimed to assess the efficacy of insulin pumps with automated predictive low-glucose insulin suspension in a real-world setting compared with stand-alone flash glucose monitoring (FGM). METHODS: - The data analyzed were uploaded by patients with type 1 diabetes (n = 195) treated with external insulin pumps [either a MiniMed 640G system (Medtronic) including SmartGuard technology that predicts and manages low glucose (n = 61) or an Omnipod patch pump accompanied by a FreeStyle Libre sensor (Abbott) for FGM (n = 134)]. RESULTS: - The median (25th-75th percentile) time spent with sensor glucose values ≤...
Source: Diabetes and Metabolism - May 31, 2020 Category: Endocrinology Authors: Telliam C, Thivolet C Tags: Diabetes Metab Source Type: research

Towards individualized and optimalized positioning of non-ventilated COVID-19 patients: Putting the affected parts of the lung(s) on top?
Abstract The outbreak of COVID-19 led to an unprecedented inflow of hospitalized patients with severe acute respiratory syndrome (SARS) requiring high-flow non-invasive oxygenation, if not invasive mechanical ventilation. While the best option in terms of non-invasive systems of oxygen delivery is still a matter of debate, it also remains unclear as to whether or not the optimal in-bed positioning of patients might also help to improve their oxygen saturation levels. On the basis of three representative cases, it is possible to propose the following hypotheses: (i) how patients are positioned has a strong influenc...
Source: Diabetes and Metabolism - May 27, 2020 Category: Endocrinology Authors: Froelich S, Mandonnet E, Julla JB, Touchard C, Laloi-Michelin M, Kevorkian JP, Gautier JF Tags: Diabetes Metab Source Type: research

Associations of visit-to-visit fasting glucose with risk of mortality: A retrospective cohort study of 48,077 people with type 2 diabetes.
CONCLUSION: Variability of visit-to-visit FG may be a more sensitive predictor of risk of death than mean-FG in people with T2D. PMID: 32470380 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 25, 2020 Category: Endocrinology Authors: Xu H, Zhang Y, Xu W, Chen L, Zhang M, Su H, Cheng Y, Zhao N, Xu D, Qin G Tags: Diabetes Metab Source Type: research

Anaemia and its risk factors and association with treatments in patients with diabetes: a cross-sectional study.
CONCLUSION: - This study has confirmed that anaemia is frequently seen in diabetes patients and strongly associated with renal failure (already at stage 2). Our observations highlight the adjuvant role of drugs, particularly RASBs, in the risk of anaemia in patients with diabetes. PMID: 32461154 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 23, 2020 Category: Endocrinology Authors: Brière M, Diedisheim M, Dehghani L, Dubois-Laforgue D, Larger E Tags: Diabetes Metab Source Type: research

Septic shock with methicillin-sensitive Staphylococcus aureus secondary to continuous subcutaneous insulin infusion by external pump.
PMID: 32461155 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 23, 2020 Category: Endocrinology Authors: Hamou AB, Maurou O, Nadler S, Dupuy O Tags: Diabetes Metab Source Type: research

COVID-19 symptoms masking inaugural ketoacidosis of type 1 diabetes.
PMID: 32447100 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 20, 2020 Category: Endocrinology Authors: Potier L, Julla JB, Roussel R, Boudou P, Gauthier DC, Ketfi C, Gautier JF Tags: Diabetes Metab Source Type: research

Prognostic factors in patients with diabetes hospitalized for COVID-19: Findings from the CORONADO study and other recent reports.
Abstract Diabetes mellitus is challenging in the context of the COVID-19 pandemic. The prevalence of diabetes patients hospitalized in intensive care units for COVID-19 is two- to threefold higher, and the mortality rate at least double, than that of non-diabetes patients. As the population with diabetes is highly heterogeneous, it is of major interest to determine the risk factors of progression to a more serious life-threatening COVID-19 infection. This brief review discusses the main findings of CORONADO, a prospective observational study in France that specifically addressed this issue as well as related obser...
Source: Diabetes and Metabolism - May 20, 2020 Category: Endocrinology Authors: Scheen AJ, Marre M, Thivolet C Tags: Diabetes Metab Source Type: research

Negative impact of hyperglycaemia on tocilizumab therapy in Covid-19 patients.
sso G Abstract Tocilizumab (TCZ) is used for treating moderate-to-severe Covid-19 pneumonia by targeting interleukin-6 receptors (IL-6Rs) and reducing cytokine release. Yet, in spite of this therapy, patients with vs patients without diabetes have an adverse disease course. In fact, glucose homoeostasis has influenced the outcomes of diabetes patients with infectious diseases. Of the 475 Covid-19-positive patients admitted to infectious disease departments (University of Bologna, University Vanvitelli of Napoli, San Sebastiano Caserta Hospital) in Italy since 1 March 2020, 31 (39.7%) hyperglycaemic and 47 (60.3%) ...
Source: Diabetes and Metabolism - May 20, 2020 Category: Endocrinology Authors: Marfella R, Paolisso P, Sardu C, Bergamaschi L, D'Angelo EC, Barbieri M, Rizzo MR, Messina V, Maggi P, Coppola N, Pizzi C, Biffi M, Viale P, Galié N, Paolisso G Tags: Diabetes Metab Source Type: research

Do GLP-1RAs and SGLT-2is reduce cardiovascular events in women with type 2 diabetes? A systematic review and meta-analysis.
CONCLUSIONS: In women with type 2 diabetes who either have increased cardiovascular risk or established cardiovascular disease and ASCVD predominates, GLP-1RA significantly reduce the incidence of MACE while SGLT-2i result in a non-significant reduction. SGLT-2i may have comparable effect when examined in more studies. GLP-1RA and SGLT-2i should be considered without delay in women with type 2 diabetes and increased risk for cardiovascular disease. PMID: 32439471 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 17, 2020 Category: Endocrinology Authors: Mishriky BM, Okunrintemi V, Jain S, Sewell KA, Powell JR, Cummings DM Tags: Diabetes Metab Source Type: research

Patients with diabetes are at higher risk for severe illness from COVID-19.
Abstract It is currently uncertain whether people with diabetes are at higher risk of severe illness from coronavirus disease 2019 (COVID-19). We found that diabetes was associated with an approximately 4-fold increased risk of having severe/critical COVID-19 illness. This association was independent of age, sex, obesity, hypertension and smoking. These findings highlight the urgent need for a multidisciplinary team-based approach to management of this patient population. PMID: 32416321 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 12, 2020 Category: Endocrinology Authors: Targher G, Mantovani A, Wang XB, Yan HD, Sun QF, Pan KH, Byrne CD, Zheng KI, Chen YP, Eslam M, George J, Zheng MH Tags: Diabetes Metab Source Type: research

Glycaemic control for painful diabetic peripheral neuropathy is more than fasting plasma glucose and glycated haemoglobin.
This study included 1040 participants with mean FPG levels
Source: Diabetes and Metabolism - May 11, 2020 Category: Endocrinology Authors: Pai YW, Tang CL, Lin CH, Lin SY, Lee IT, Chang MH Tags: Diabetes Metab Source Type: research

Three alternative ways to screen for hyperglycaemia in pregnancy during the COVID-19 pandemic.
son E PMID: 32387699 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 5, 2020 Category: Endocrinology Authors: Vambergue A, Jacqueminet S, Lamotte MF, Lamiche-Lorenzini F, Brunet C, Deruelle P, Vayssière C, Cosson E Tags: Diabetes Metab Source Type: research