The association between gestational diabetes mellitus and cancer in women: A systematic review and meta-analysis of observational studies.
CONCLUSION: GDM is associated with a greater risk of cancer in women, including breast, thyroid, stomach and liver cancers. However, further investigation is nonetheless warranted. PMID: 32097717 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - February 22, 2020 Category: Endocrinology Authors: Wang Y, Yan P, Tao F, Yuan J, Yang G, Liu Y, Zhang ZJ Tags: Diabetes Metab Source Type: research

Fasting and post-oral-glucose-load levels of methylglyoxal are associated with microvascular, but not macrovascular, disease in individuals with and without (pre)diabetes: The Maastricht Study.
Abstract AIMS: Reactive dicarbonyl compounds, such as methylglyoxal (MGO), rise during an oral glucose tolerance test (OGTT), particularly in (pre)diabetes. Fasting MGO levels are associated with chronic kidney disease (CKD) and cardiovascular disease (CVD) in patients with poorly controlled type 2 diabetes mellitus (T2DM). Yet, whether fasting or post-OGTT plasma MGO levels are associated with vascular disease in people with (pre)diabetes is unknown. METHODS: Subjects with normal glucose metabolism (n = 1796; age: 57.9 ± 8.2 years; 43.3% men), prediabetes (n = 478; age: 61.6 ± 7.6 years; 54.0% ...
Source: Diabetes and Metabolism - February 10, 2020 Category: Endocrinology Authors: Hanssen NM, Scheijen JLJM, Houben AJHM, van de Waarenburg M, Berendschot TTJM, Webers CAB, Reesink KD, Greevenbroek MMJV, Kallen CV, Schaper NC, Schram MT, Henry RMA, Stehouwer CDA, Schalkwijk CG Tags: Diabetes Metab Source Type: research

PNPLA3 Polymorphism Influences The Association Between High-Normal Tsh Level And Nash In Euthyroid Adults With Biopsy-Proven Nafld.
CONCLUSION: In euthyroid individuals with biopsy-proven NAFLD, we found a significant association between high-normal TSH levels and NASH. After stratifying by PNPLA3 rs738409 genotypes, this association was observed only among carriers of the PNPLA3 G risk allele. PMID: 32035968 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - February 6, 2020 Category: Endocrinology Authors: Hu DS, Zhu SH, Liu WY, Pan XY, Zhu PW, Li YY, Zheng KI, Ma HL, You J, Targher G, Byrne CD, Chen YP, Zheng MH Tags: Diabetes Metab Source Type: research

Number Needed-to-Treat (NNT): is it a necessary marker of therapeutic efficiency?
PMID: 32035226 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - February 5, 2020 Category: Endocrinology Authors: Monnier L, Colette C, Bonnet F, Owens D Tags: Diabetes Metab Source Type: research

Roux-en-Y gastric bypass, but not sleeve gastrectomy, decreases plasma PCSK9 levels in morbidly obese patients.
Abstract AIM: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a master regulator of low-density lipoprotein cholesterol (LDL-C) metabolism, acting as an endogenous inhibitor of the LDL receptor. While it has been shown that bariatric surgery differentially affects plasma LDL-C levels, little is known of its effects on plasma PCSK9 concentrations. Therefore, the present study aimed to: (i) investigate the effect of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) on plasma PCSK9 concentrations; and (ii) correlate baseline or postoperative plasma PCSK9 concentration variations with anthropometric...
Source: Diabetes and Metabolism - February 4, 2020 Category: Endocrinology Authors: Blanchard C, Ledoux S, Verhaegen A, Wargny M, Letessier E, Stepanian A, Huten N, Jacobi D, Krempf M, Bras ML, Guillouche MP, Arnaud L, Pichelin M, Gaal LV, Cariou B, May CL Tags: Diabetes Metab Source Type: research

Reduction in HbA1c with SGLT2 inhibitors vs DPP-4 inhibitors as add-ons to metformin monotherapy according to baseline HbA1c: a systematic review of randomized controlled trials.
This study compared the reduction of glycated haemoglobin (HbA1c) with sodium-glucose cotransporter type-2 inhibitors (SGLT2is) vs dipeptidyl peptidase-4 inhibitors (DPP-4is) as add-ons to metformin in patients with type 2 diabetes mellitus (T2DM), with a specific focus on HbA1c changes according to baseline HbA1c. MATERIALS AND METHODS: PubMed and Embase databases were scrutinized for randomized controlled trials (RCTs) evaluating the reduction of HbA1c from baseline (Δ HbA1c) with an SGLT2i or DPP-4i in patients with T2DM not well controlled by metformin monotherapy. The endpoint was Δ HbA1c using both i...
Source: Diabetes and Metabolism - January 30, 2020 Category: Endocrinology Authors: Scheen AJ Tags: Diabetes Metab Source Type: research

Remission of necrobiosis lipoidica diabeticorum with a JAK1/2 inhibitor: A case report.
PMID: 31981714 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - January 22, 2020 Category: Endocrinology Authors: Barbet-Massin MA, Rigalleau V, Blanco P, Mohammedi K, Poupon P, Belin E, Poursac N, Cadart O, Blanco L Tags: Diabetes Metab Source Type: research

Is the type 2 diabetes epidemic plateauing in France? A nationwide population-based study.
CONCLUSION: Further efforts towards diabetes prevention are required to ensure that incidence rates in France continue to diminish, as the disorder continues to represent an important public-health burden. PMID: 31923577 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - January 7, 2020 Category: Endocrinology Authors: Fuentes S, Mandereau-Bruno L, Regnault N, Bernillon P, Bonaldi C, Cosson E, Fosse-Edorh S Tags: Diabetes Metab Source Type: research

Efficacy and safety of anti-hyperglycaemic drugs in patients with non-alcoholic fatty liver disease with or without diabetes: an updated systematic review of randomized controlled trials.
CONCLUSION: - RCT evidence supports the efficacy of some anti-hyperglycaemic agents (especially pioglitazone) in patients with NAFLD or NASH, though weight gain with pioglitazone may warrant caution. Further well-designed RCTs are needed to better characterize the efficacy and safety of monotherapy and combination therapy with anti-hyperglycaemic agents in patients with NAFLD. PMID: 31923578 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - January 7, 2020 Category: Endocrinology Authors: Mantovani A, Byrne CD, Scorletti E, Mantzoros CS, Targher G Tags: Diabetes Metab Source Type: research

Lung function as a predictor of incident type 2 diabetes in community-dwelling adults: A longitudinal finding over 12 years from the Korean Genome and Epidemiology Study.
CONCLUSION: Reduced lung function precedes and significantly predicts the future development of T2D independently of obesity, smoking and inflammation in community-dwelling middle-aged and elderly people. PMID: 31884177 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 26, 2019 Category: Endocrinology Authors: Lee JH, Lee HS, Lee YJ Tags: Diabetes Metab Source Type: research

Prevalence of anti-GAD and IA2 autoantibodies in a French cohort of patients with diabetes eligible for bariatric surgery.
PMID: 31874247 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 21, 2019 Category: Endocrinology Authors: Martin C, Ait Boudaoud A, Poghosyan T, Zhu J, Larger E, Greenfield JR, Czernichow S, Rives-Lange C, Carette C Tags: Diabetes Metab Source Type: research

Associations of serum magnesium levels and calcium-magnesium ratios with mortality in patients with coronary artery disease.
CONCLUSION: This study demonstrated that a moderate Ca-Mg ratio (range: 3.91-4.70) had the lowest mortality risk, and that low serum Mg and high Ca-Mg ratio were independent risk factors of mortality in CAD patients. Nevertheless, the optimal dose-response of Mg and Ca for mitigating CAD risk still requires further investigation. PMID: 31870835 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 20, 2019 Category: Endocrinology Authors: Li Q, Chen Q, Zhang H, Xu Z, Wang X, Pang J, Ma J, Ling W, Li D Tags: Diabetes Metab Source Type: research

Dietary sodium and potassium and risk of diabetes: A prospective study using data from the China Health and Nutrition Survey.
Abstract AIMS: - Dietary sodium and potassium intakes are well-known risk factors for cardiovascular outcomes. However, the associations between dietary sodium and potassium and diabetes are still controversial. Our study aimed to examine whether dietary sodium, potassium and the sodium-potassium ratio are associated with the risk of diabetes, based on a large sample of Chinese adults. METHODS: - The study data were from the 2004-2009 China Health and Nutrition Survey (CHNS), and 5867 participants were eligible for analysis. Sodium and potassium intakes were estimated based on three consecutive 24-h recalls a...
Source: Diabetes and Metabolism - December 12, 2019 Category: Endocrinology Authors: Hao G, Liu K, Halbert JD, Chen H, Wu J, Jing C Tags: Diabetes Metab Source Type: research

Eating behaviours associated with glycaemic variability and fear of hypoglycaemia in adults with type 1 diabetes.
PMID: 31838059 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 12, 2019 Category: Endocrinology Authors: De Luca A, Baudry VA, Wargny M, Chaillous L, Hadjadj S, Cariou B, Dubois S, Briet C, Kerlan IV, Fradet I, Fradet G, Gouet D, Perlemoine C, Ragot S, Saulnier PJ, Ducluzeau PH, VARDIA study group Tags: Diabetes Metab Source Type: research

SGLT2 Inhibition Increases Serum Copeptin in Young Adults with Type 1 Diabetes.
Abstract AIMS: - Copeptin, a surrogate of vasopressin, is elevated in type 1 diabetes (T1D) and predicts kidney disease and cardiovascular mortality. Given the cardiorenal protective effects of SGLT2 inhibition (SGLT2i), our aim was to examine: 1) the relationship between serum copeptin, metabolic, renal and systemic hemodynamic parameters in adults with T1D; and 2) serum copeptin after SGLT2i with empagliflozin. MATERIALS AND METHODS: - In this post-hoc, exploratory analysis, serum copeptin, glomerular filtration rate (GFRInulin), effective renal plasma flow (ERPFPAH), plasma renin angiotensin aldosterone sy...
Source: Diabetes and Metabolism - December 6, 2019 Category: Endocrinology Authors: Lytvyn Y, Bjornstad P, Katz A, Singh SK, Godoy LC, Chung LT, Vinovskis CL, Pyle L, Roussel R, Perkins BA, Cherney D Tags: Diabetes Metab Source Type: research

Effects of 12-week treatment with dapagliflozin and gliclazide on faecal microbiome: Results of a double-blind randomized trial in patients with type 2 diabetes.
CONCLUSION: Even though gliclazide and dapagliflozin have different metabolic actions in patients with T2D, neither treatment altered the faecal microbiome, thereby suggesting that the observed metabolic changes are not mediated by their effects on the microbiota. TRIAL REGISTRATION: ClinicalTrials.gov ID NCT02682563 Funding: The study was funded by AstraZeneca. PMID: 31816432 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - December 6, 2019 Category: Endocrinology Authors: Bommel EJMV, Herrema H, Davids M, Kramer MHH, Nieuwdorp M, Raalte DHV Tags: Diabetes Metab Source Type: research

Higher liver stiffness scores are associated with early kidney dysfunction in patients with histologically proven non-cirrhotic NAFLD.
Abstract AIM: The association between liver fibrosis (LF), as assessed by either histology or liver stiffness measurement (LSM), and the presence of early kidney dysfunction (EKD) was investigated in this study, as was also the diagnostic performance of LSM for identifying the presence of EKD in patients with non-alcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: A total of 214 adults with non-cirrhotic biopsy-proven NAFLD were recruited from two independent medical centres. Their histological stage of LF was quantified using Brunt's criteria. Vibration-controlled transient elastography (TE), using...
Source: Diabetes and Metabolism - November 28, 2019 Category: Endocrinology Authors: Sun DQ, Ye FZ, Kani HT, Yang JR, Zheng KI, Zhang HY, Targher G, Byrne CD, Chen YP, Yuan WJ, Yilmaz Y, Zheng MH Tags: Diabetes Metab Source Type: research

Screening for non-alcoholic fatty liver disease using liver stiffness measurement and its association with chronic kidney disease and cardiovascular complications in patients with type 2 diabetes.
This study explored the proportion of NAFLD cases and increased liver fibrosis (LF), and the association between LF and either chronic kidney disease (CKD) or cardiovascular complications in T2DM patients. METHODS: - The study included 137 patients with non-insulin-treated T2DM and no known liver disease consecutively attending our diabetes outpatients service who underwent liver ultrasonography and liver stiffness measurement (LSM) using vibration-controlled transient elastography (FibroScan®). RESULTS: - The proportion of patients with hepatic steatosis on ultrasonography was 73.7%, and the proportion with ...
Source: Diabetes and Metabolism - November 28, 2019 Category: Endocrinology Authors: Mantovani A, Turino T, Lando MG, Gjini K, Byrne CD, Zusi C, Ravaioli F, Colecchia A, Maffeis C, Salvagno G, Lippi G, Bonora E, Targher G Tags: Diabetes Metab Source Type: research

Determinants of aspirin resistance in patients with type 2 diabetes.
CONCLUSION: Our results reveal that 'aspirin resistance' is frequently found in T2DM, and is strongly related to insulin resistance and severity of CAD, but weakly related to HbA1c and not at all to inflammatory parameters. This may help to identify those T2DM patients who might benefit from alternative antiplatelet treatments such as twice-daily aspirin and thienopyridines. PMID: 31783142 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - November 26, 2019 Category: Endocrinology Authors: Paven E, Dillinger JG, Sollier CBD, Trecan TV, Berge N, Dautry R, Gautier JF, Drouet L, Riveline JP, Henry P Tags: Diabetes Metab Source Type: research

Socioeconomic inequalities and type 2 diabetes complications: A systematic review.
CONCLUSION: Evaluation of SES is necessary for every T2D patient, as it appears to be a risk factor for diabetes complications. However, the available studies are insufficient for gradation of the impact of low socioeconomic level on each of these complications. Regardless, strategies for the improved screening, follow-up and care of high-risk patients should now be implemented. PMID: 31759171 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - November 20, 2019 Category: Endocrinology Authors: Tatulashvili S, Fagherazzi G, Dow C, Cohen R, Fosse S, Bihan H Tags: Diabetes Metab Source Type: research

Challenging 2019 ESC guidelines for the management of type 2 diabetes.
PMID: 31707046 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - November 7, 2019 Category: Endocrinology Authors: Scheen AJ Tags: Diabetes Metab Source Type: research

Circulating omega-7 fatty acids are differentially related to metabolic dysfunction and incident type II diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA).
Abstract AIM: Determine whether plasma omega-7 vaccenic acid and palmitoleic acid levels are related to homeostasis model of insulin resistance scores and incident type II diabetes, and whether race/ethnicity modifies these associations. METHODS: Plasma phospholipid fatty acids were measured by gas chromatography with flame-ionization detection in Multi-Ethnic Study of Atherosclerosis participants. Linear regression determined associations of vaccenic acid and palmitoleic acid with log-transformed homeostasis model of insulin resistance scores (N=5689), and Cox regression determined associations with incident...
Source: Diabetes and Metabolism - November 6, 2019 Category: Endocrinology Authors: Weir NL, Steffen BT, Guan W, Johnson LM, Djousse L, Mukamal KJ, Tsai MY Tags: Diabetes Metab Source Type: research

Sarcopenia is associated with non-alcoholic fatty liver disease in men with type 2 diabetes.
Abstract AIMS: Recent epidemiological studies have suggested an association between sarcopenia and non-alcoholic fatty liver disease (NAFLD) in the general population, prompting our investigation into the gender-specific association between sarcopenia and NAFLD in patients with type 2 diabetes mellitus (T2DM). METHODS: In this cross-sectional study, 4210 patients with T2DM were recruited from the Seoul Metabolic Syndrome Cohort. Appendicular skeletal muscle mass (ASM) was estimated from bioimpedance analysis measurements, and the skeletal muscle mass index (SMI) was calculated by dividing the sum of ASM by bo...
Source: Diabetes and Metabolism - November 2, 2019 Category: Endocrinology Authors: Da HS, Lee YH, Park SW, Choi YJ, Huh BW, Lee E, Huh KB, So HK, Cha BS Tags: Diabetes Metab Source Type: research

The gut microbiota and diabetic cardiomyopathy in humans.
Abstract Type 2 diabetes (DT2) increases the risk of cardiovascular events and cardiac insufficiency. This insufficiency is mostly post-ischaemic in nature, but other aetiologies are possible in this high-risk population. In patients with DT2, diabetic cardiomyopathy is a recognized cause of cardiac insufficiency secondary to chronic hyperglycaemia and myocardial lipotoxicity, which promotes cardiomyocyte hypertrophy (and, frequently, apoptosis of these cells), interstitial fibrosis and a decrease in myocardial contractile performance. Several studies have shown that diabetic cardiomyopathy is associated with modi...
Source: Diabetes and Metabolism - October 30, 2019 Category: Endocrinology Authors: Bastin M, Andreelli F Tags: Diabetes Metab Source Type: research

Insulin secretion and sensitivity before and after surgical treatment for aldosterone-producing adenoma.
CONCLUSION: - Primary aldosteronism impairs insulin secretion. PMID: 31676325 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - October 29, 2019 Category: Endocrinology Authors: Komada H, Hirota Y, So A, Nakamura T, Okuno Y, Fukuoka H, Iguchi G, Takahashi Y, Sakaguchi K, Ogawa W Tags: Diabetes Metab Source Type: research

Performance of a selective screening strategy for diagnosis of hyperglycaemia in pregnancy as defined by IADPSG/WHO criteria.
Abstract AIM: Our study evaluated the performance of a selective screening strategy for hyperglycaemia in pregnancy (HIP) based on the presence of risk factors (RFs; body mass index ≥ 25 kg/m², age ≥ 35 years, family history of diabetes, personal history of HIP or macrosomia) to diagnose HIP and to predict HIP-related events. METHODS: Women with no known diabetes who had undergone complete universal screening (early, before 22 weeks of gestation or, if not, in the second part of pregnancy) at our department (2012-2016) were selected, resulting in four groups of women according to the presence of HI...
Source: Diabetes and Metabolism - October 28, 2019 Category: Endocrinology Authors: Cosson E, Vicaut E, Sandre-Banon D, Gary F, Pharisien I, Portal JJ, Baudry C, Cussac-Pillegand C, Costeniuc D, Valensi P, Carbillon L Tags: Diabetes Metab Source Type: research

Efficacy of semaglutide versus liraglutide in clinical practice.
PMID: 31606525 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - October 10, 2019 Category: Endocrinology Authors: Goncalves E, Bell DS Tags: Diabetes Metab Source Type: research

High frequency of transaminase elevation following diabetic ketoacidosis.
PMID: 31606526 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - October 10, 2019 Category: Endocrinology Authors: Tiercelin C, Lemoine AY, Ratheau L, Larger E Tags: Diabetes Metab Source Type: research

Mortality in patients with diabetic foot ulcer: diabetic neuropathy is not innocent.
PMID: 31568843 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 27, 2019 Category: Endocrinology Authors: Simoneau A, Foussard N, Blanco L, Domenge F, Monlun M, Poupon P, Rigalleau V Tags: Diabetes Metab Source Type: research

Alirocumab efficacy and safety by body mass index: a pooled analysis from 10 Phase 3 ODYSSEY trials.
CONCLUSIONS: - Alirocumab provided consistent LDL-C reductions, with similar safety findings across BMI subgroups. PMID: 31533069 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 15, 2019 Category: Endocrinology Authors: Tinahones FJ, Laufs U, Cariou B, Louie MJ, Yang J, Thompson D, Leiter LA Tags: Diabetes Metab Source Type: research

Diabetes confers a higher risk of mortality among women in a middle-income country: Results from the Mexican Teachers' Cohort study.
CONCLUSION: - In women with healthcare coverage in Mexico, the magnitude of the association between diabetes and all-cause mortality was higher than that observed in high-income countries, but less than what has previously been reported for Mexico. Such elevated mortality suggests a lack of adequate access to quality diabetes care in the population despite comprehensive healthcare coverage. PMID: 31525457 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 13, 2019 Category: Endocrinology Authors: Lozano-Esparza S, López-Ridaura R, Ortiz-Panozo E, González-Villalpando C, Aguilar-Salinas C, Hernández-Ávila JE, Hernández-Ávila M, Lajous M Tags: Diabetes Metab Source Type: research

Calibration free continuous glucose monitoring (CGM) devices: weighing up the benefits and limitations.
PMID: 31520684 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 11, 2019 Category: Endocrinology Authors: Monnier L, Colette C, Owens D Tags: Diabetes Metab Source Type: research

Competing risk analysis on visit-to-visit glucose variations and risk of depression: The Taiwan Diabetes Study.
CONCLUSION: Patients whose 1-year FPG variations were> 42.6% had an increased risk of depression, thus suggesting that FPG variations may be a predictor of depression in patients with T2D. Also, glucose variation during outpatient visits may be an indicator for individualized diabetes management in clinical practice. PMID: 31472230 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - August 28, 2019 Category: Endocrinology Authors: Li CI, Liu CS, Lin CH, Lin WY, Lee YD, Yang SY, Li TC, Lin CC Tags: Diabetes Metab Source Type: research

Insulin autoimmune syndrome in patients with type 2 diabetes: A report of two cases.
PMID: 31445080 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - August 21, 2019 Category: Endocrinology Authors: Shin Y, Tae Jung O, Choi SH, Jang HC Tags: Diabetes Metab Source Type: research

Disagreement between capillary blood glucose and flash glucose monitoring sensor can lead to inadequate treatment adjustments during pregnancy.
Abstract OBJECTIVE: Continuous glucose monitoring tends to replace capillary blood glucose (CBG) self-monitoring. Our aim was to determine the agreement between CBG and a flash glucose monitoring system (Flash-GMS) in treatment decision-making during pregnancy. RESEARCH DESIGN AND METHODS: Insulin-treated women with either type 1 (n = 25), type 2 (n = 4) or gestational diabetes (n = 4) were included. A Flash-GMS sensor was applied for 14 days. Women scanned the sensor whenever they wished to monitor their CBG. The primary endpoint was the proportion of discordant therapeutic decisions they would have made bas...
Source: Diabetes and Metabolism - August 12, 2019 Category: Endocrinology Authors: Sola-Gazagnes A, Faucher P, Jacqueminet S, Ciangura C, Laforgue DD, Pudar HM, Roussel R, Larger E Tags: Diabetes Metab Source Type: research

Five-year mortality in patients with diabetic foot ulcer during 2009-2010 was lower than expected.
Abstract AIM: Mortality rates are decreasing in patients with diabetes. However, as this observation also concerns patients with diabetic foot ulcer (DFU), additional data are needed. For this reason, our study evaluated the 5-year mortality rate in patients with DFU during 2009-2010 and identified risk factors associated with mortality. METHODS: Consecutive patients who attended a clinic for new DFU during 2009-2010 were followed until healing and at 1 year. Data on mortality were collected at year 5. Multivariate Cox proportional-hazards model was used to identify mortality risk factors. RESULTS: A tot...
Source: Diabetes and Metabolism - August 7, 2019 Category: Endocrinology Authors: Amadou C, Carlier A, Amouyal C, Bourron O, Aubert C, Couture T, Fourniols E, Van GH, Rouanet S, Hartemann A Tags: Diabetes Metab Source Type: research

Type 2 diabetes: why should diabetologists and cardiologists work more closely together.
PMID: 31394190 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - August 5, 2019 Category: Endocrinology Authors: Valensi P, Picard S, Pathak A Tags: Diabetes Metab Source Type: research

Associations between specific plasma ceramides and severity of coronary-artery stenosis assessed by coronary angiography.
CONCLUSION: Our cross-sectional study shows for the first time that higher levels of specific plasma ceramides are independently associated with a greater severity of coronary-artery stenoses in the LAD artery in patients who had suspected or established CAD. PMID: 31386900 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - August 3, 2019 Category: Endocrinology Authors: Mantovani A, Bonapace S, Lunardi G, Canali G, Dugo C, Vinco G, Calabria S, Barbieri E, Laaksonen R, Bonnet F, Byrne CD, Targher G Tags: Diabetes Metab Source Type: research

Antipsychotic exposure duration and prediction of risk of hyperglycaemic crisis episodes: Drs He and Shen reply.
PMID: 31386901 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - August 3, 2019 Category: Endocrinology Authors: He MR, Shen YC Tags: Diabetes Metab Source Type: research

Liraglutide 3mg as a weight-loss strategy after failed bariatric surgery in a patient with hypothalamic obesity following craniopharyngioma.
PMID: 31362076 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - July 27, 2019 Category: Endocrinology Authors: Bretault M, Carette C, Zaharia R, Vychnevskaia K, Bouillot JL, Czernichow S, Raffin-Sanson ML Tags: Diabetes Metab Source Type: research

Metabolic And Psychological Effects Of Short-Term Increased Consumption Of Less-Processed Foods In Daily Diets: A Pilot Study.
This study evaluated whether the consumption of locally produced food without additives might have a positive effect on known risk factors for non-communicable diseases (NCDs) such as hypertension, and levels of fasting glucose and visceral adipose tissue (VAT). Attention was focused on various types of cheese, sausages, fresh pasta, pastries, biscuits and chocolate without additives to make them palatable and durable for transport. METHODS: - Healthy volunteers were randomized to purchase the foods under study from either local producers not using additives (group 1) or supermarkets (group 2). At baseline and after 6...
Source: Diabetes and Metabolism - July 17, 2019 Category: Endocrinology Authors: Migliaretti G, Ame C, Ciullo S, Fontana E, Stura I, Nano E, Laino F, Isoardo G Tags: Diabetes Metab Source Type: research

Serum fructosamine predicts macrosomia in well-controlled hyperglycaemic pregnant women: an observational cross-sectional study.
Abstract AIM: While serum fructosamine may be a good marker of glucose control in pregnant women with diabetes, its relationship with macrosomia is still uncertain. METHODS: In 130 hyperglycaemic women with singleton pregnancies (117 gestational diabetes mellitus, 13 pregestational diabetes), serum fructosamine and HbA1c levels were measured at 25 ± 7 weeks of gestation. Levels in mothers of infants with and without macrosomic newborns (birth weight> 4000 g and/or large-for-gestational-age birth weight> 90th percentile) were compared using logistic regression analysis adjusted for macrosomia risk...
Source: Diabetes and Metabolism - July 17, 2019 Category: Endocrinology Authors: Poupon P, Foussard N, Helmer C, Cougnard-Gregoire A, Rajaobelina K, Delcourt C, Lamireau T, Haissaguerre M, Blanco L, Alexandre L, Mohammedi K, Rigalleau V Tags: Diabetes Metab Source Type: research

Antipsychotic exposure duration and prediction of risk of hyperglycaemic crisis episodes: more than just time.
PMID: 31323367 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - July 16, 2019 Category: Endocrinology Authors: Polcwiartek C Tags: Diabetes Metab Source Type: research

A low-carbohydrate high-fat diet initiated promptly after diagnosis provides clinical remission in three patients with type 1 diabetes.
e;s B PMID: 31301353 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - July 10, 2019 Category: Endocrinology Authors: Bouillet B, Rouland A, Petit JM, Vergès B Tags: Diabetes Metab Source Type: research

Factors Associated with Pneumococcal Vaccination in 2040 People with Type 2 Diabetes: A Cross-sectional Study.
CONCLUSION: Based on this information, future programs aimed at people aged
Source: Diabetes and Metabolism - June 27, 2019 Category: Endocrinology Authors: Gilani F, Majumdar SR, Johnson JA, Simpson SH, ABCD Cohort Investigators Tags: Diabetes Metab Source Type: research

Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. cohort.
CONCLUSION: These results show that, in women, there is an inverse association between fresh dairy product consumption and predictive markers (dihydroceramides) of type 2 diabetes. PMID: 31212089 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - June 15, 2019 Category: Endocrinology Authors: Fumeron F, Nicolas A, Bastard JP, Fellahi S, Wigger L, Ibberson M, Cruciani-Guglielmacci C, Stunff HL, Velho G, Magnan C, Marre M, Balkau B, Roussel R Tags: Diabetes Metab Source Type: research

Risk of hyperglycaemic crisis episode in diabetic patients with schizophrenia: A nationwide population-based cohort study.
CONCLUSION: - This study highlights the need to pay more attention to the risk of HCE in diabetic patients with schizophrenia and the importance of proper use of antipsychotics may reduce the risk of HCE. Abbreviation: SCZ: schizophrenia; DM: diabetes mellitus. PMID: 31200113 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - June 11, 2019 Category: Endocrinology Authors: Chen SF, Yang YC, Hsu CY, Shen YC Tags: Diabetes Metab Source Type: research

Association between specific plasma ceramides and high-sensitivity C-reactive protein levels in postmenopausal women with type 2 diabetes.
CONCLUSION: In postmenopausal women with T2DM, elevated levels of specific plasma ceramides are associated with higher plasma hs-CRP levels independent of established cardiovascular risk factors, diabetes-related variables and other potential confounding factors. PMID: 31185304 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - June 8, 2019 Category: Endocrinology Authors: Mantovani A, Altomari A, Lunardi G, Bonapace S, Lippi G, Bonnet F, Targher G Tags: Diabetes Metab Source Type: research

Effect of maternal lifestyle intervention on metabolic health and adiposity of offspring: Findings from the Finnish Gestational Diabetes Prevention Study (RADIEL).
CONCLUSION: - The lifestyle intervention aimed at GDM prevention was associated with unfavourable metabolic outcomes among offspring at around 5 years of age. PMID: 31175958 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - June 5, 2019 Category: Endocrinology Authors: Grotenfelt NE, Wasenius N, Eriksson JG, Huvinen E, Stach-Lempinen B, Koivusalo SB, Rönö K Tags: Diabetes Metab Source Type: research

Regulation of hepatokine gene expression in response to fasting and feeding: Influence of PPAR- α and insulin-dependent signalling in hepatocytes.
CONCLUSION: - The present results highlight the potential roles of hepatokines as a class of hormones that substantially influence nutritional regulation in both female and male mice. PMID: 31163275 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - June 1, 2019 Category: Endocrinology Authors: Smati S, Régnier M, Fougeray T, Polizzi A, Fougerat A, Lasserre F, Lukowicz C, Tramunt B, Guillaume M, Burnol AF, Postic C, Wahli W, Montagner A, Gourdy P, Guillou H Tags: Diabetes Metab Source Type: research